Journal of Pharmacological Sciences 97巻 suppl.2号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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The potent PAR-2 agonist 2-furoly-LIGRL-amide is a powerful and orally available gastric mucosal protective agent

Daiki Yonezawa1), Yuko Oono1), Naoki Inoi1), Masami Honjo1), Michiko Hirofuchi1), Fumiko Sekiguchi1), Masahiro Iwaki2), Toru Kanke3), Hiroyuki Ishiwata3), Atsufumi Kawabata1)
1)Div. Physiol. Pathophysiol., Sch. Pharmaceut. Sci., Kinki Univ, 2)Div. Biopharmaceut. Sci., Sch. Pharmaceut. Sci., Kinki Univ., 3)Tokyo New Drug Res. Lab. II, Pharmaceut. Div., Kowa
Journal of Pharmacological Sciences 97 (suppl.2) 198-198, 2005.

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Pharmacological study on the autonomic innervation of the gastric and colonic muscularis mucosae isolated from human

Kohsuke Uchida1), Asako Shibukawa1), Shu-ichi Kojima1), Kinro Sasaki2), Kazuto Miyaji2), Masakatu Sunagawa2), Yasuo Ohno3), Yuichiro Kamikawa1)
1)Dept. Pharmacol., Dokkyo Univ. Sch. Med., 2)Dept. Surgery I, Dokkyo Univ. Sch. Med., 3)Div. Pharmacol., Nat. Inst. Hygi. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 198-198, 2005.

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Muscarinic receptor subtype responsible for parasympathetic control of pancreatic exocrine secretion

Takeshi Nakamura1), Kyoko Nakamura1), Nagisa Matsumoto2), Minoru Matsui3), Toshiya Manabe3), Katsuhiko Mikoshiba1)2)
1)Calcium Oscillation Project, ICORP, JST, 2)Mol. Neurobiol., Inst. Med. Sci., Tokyo Univ., 3)Neural Network, Inst. Med. Sci., Tokyo Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 198-198, 2005.

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Effects of angiotensin II on liver regeneration

Ryoko MiyagI, Katsutoshi Yayama, Masaoki Takano, Hiroshi Okamoto
Dept. Pharmacol., Fac. Pharm. Sci., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 198-198, 2005.

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Histopathological analysis for proliferative changes in upper digestive tract of rats given a single dose of alloxan

Yasushi Kodama1), Kiyokazu Ozaki2), Tetsuro Matsuura2), Hiroyuki Akagi1), Isao Narama2)
1)Lab. Mol. Cell. Toxicol., Pharmaceutical Sci., Hiroshima Int. Univ., 2)Dept. Pathology, Setsunan Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 199-199, 2005.

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FK506 ameliorates both steroid responsive and refractory colitis in IL-10 knockout mice

Yasunori Nagakura, Mariko Ota, Takahisa Noto, Noriaki Maeda, Yuji Sudo, Seitaro Mutoh
Medicinal Biology Res. Laboratories, Fujisawa Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 199-199, 2005.

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Exogenous histamine stimulates colon cancer implant growth via immunosuppression in mice

Kazuyoshi Tomita1)2), Kikuko Amagase1)2), Susumu Okabe2)
1)Dept. of Pharmacol. and Exp. Ther., Kyoto Pharm. Univ., 2)Dept. of Applied Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 199-199, 2005.

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Relationship between gastrointestinal muscularis inflammation and dysmotility: Analysis in hapten-induced colitis model rat

Masaharu Kiyosue, Masahiko Fujisawa, Masatoshi Hori, Hiroshi Ozaki
Dept. of Vet. Pharmacol., Grad. Sch. of Agri. and Life Sci., The Univ. of Tokyo
Journal of Pharmacological Sciences 97 (suppl.2) 199-199, 2005.

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Role of PGD2/CRTH2 in LPS-inducible iNOS gene expression in ileal muscularis resident macrophages

Tsuyoshi Tajima1), Masatoshi Hori1), Kosuke Aritake2), Yoshihiro Urade2), Hiroshi Ozaki1)
1)Dept. of Vet. Pharmacol., Grad. Sch. of Agri. and Life Sci., The Univ. of Tokyo., 2)Dept. of Mol. Behavioral Biology, Osaka BioSci. Inst.
Journal of Pharmacological Sciences 97 (suppl.2) 200-200, 2005.

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Intestinal dysmotility in a spontaneous Crohn's disease model mouse SAMP1/Yit

Yasuyo Yamamoto1), Masatoshi Hori1), Satoshi Matsumoto2), Yoshinori Umesaki2), Hiroshi Ozaki1)
1)Dept. of Vet. Pharmacol., Grad. Sch. of Agri. and Life Sci., The Univ. of Tokyo, 2)Yakult Central Inst. for Microbiological Res.
Journal of Pharmacological Sciences 97 (suppl.2) 200-200, 2005.

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Microarray analysis of clock-controlled gene in the mouse digestive organ

Takashi Kudo1), Toru Tamagawa1), Atsuko Sunaga1), Masashi Akiyama2), Shigenobu Shibata1)
1)Dept. of Pharmacol. Sch. of Sci. and Engineering Waseda Univ., 2)Dept. of Biophysics and Biochemistry, Grad. Sch. of Sci., The Univ. of Tokyo
Journal of Pharmacological Sciences 97 (suppl.2) 200-200, 2005.

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Mode of action of AZD0865, a proton pump selective, potassium-competitive acid blocker (P-CAB)

Yosuke Murata
Preclinical Sci. Dept., R&D, AstraZeneca KK,
Journal of Pharmacological Sciences 97 (suppl.2) 200-200, 2005.

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Functional characterization and tissue localization of SLC22 organic anion transporter OAT7

Ho lung Shin, Naohiko Anzai, Atsushi Enomoto, Do Kyung Kim, Yoshikatsu Kanai, Hitoshi Endou
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 201-201, 2005.

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Calcium-dependent and -independent signaling pathways are involved in thromboxane A2-induced fibroblast contraction in wound healing

Hiroko Yoshida1), Koji Nobe1), Hiromi Nobe1), Richard J. Paul2), Kazuo Honda1)
1)Dept. Pharmacol., Showa Univ. Sch. Pharm., 2)Dept. Mol. Cell. Physiol., Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 201-201, 2005.

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UV-induced ketoprofen radical and reactive oxygen species generation involved in photocontact deamatitis of topical ketoprofen

Yuki Kuwana1), Masahumi Ohro1), Shingo Takatori2), Mitsunobu Mio2), Yuji Kurosaki3), Fusako Takayama1), Hiromu Kawasaki1)
1)Dept. Clin. Pharmc. So., Grad. Sch. Nat. So. Tech., Okayama Univ., 2)Lab Pharmacol., Dept Clin. Pharm. Sch. Pharm., Shujitsu Univ., 3)Dept. Clin. Pharmacokin. Pharmaceut., Fac. Pharmaceut. Sci., Okayama Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 201-201, 2005.

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Effect of apple polyphenols on pruritus behavior and IL-8 expression in pinna cells in ICR mice by inducing acidophil leukocyte permeation

Shigeki Ishihama, Shigeru Taguchi, Toshiaki Terada, Tetsuyuki Kano, Tsuyoshi Yamanaka, Teruhiko Matsumiya
Dept. Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 201-201, 2005.

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PPARγ ligand activity of ginkgolic acid-related compounds

Hiromi Yoshida1), Norimasa Tamehiro1), Toshihiro Hashimoto2), Tomoko Nishimaki-Mogami1), Teruhide Yamaguchi3), Yasuo Ohno4), Taku Nagao5), Yoshinori Asakawa2), Kazuhide Inoue1), Yoji Sato3)
1)Dept. Biosignal., NIHS, Tokyo, 2)Dept. Pharm. Chem., Tokushima Bunri Univ., Tokushima, 3)Div. Cell. Gene Thpy. Prod., NIHS, 4)Div. Pharmacol., NIHS, 5)NIHS
Journal of Pharmacological Sciences 97 (suppl.2) 202-202, 2005.

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Enhanced adenosine-mediated inhibition of excitatory transmission in the central amygdala in the animal models of the neuropathic pain

Ryo Ikeda1)2), Katsuyuki Fujii2), Fusao Kato1)
1)Lab. Neurophysiol., Jikei Univ. Sch. Med., 2)Dept. Orthopedics, Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 202-202, 2005.

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Spinal and peripheral analgesic action of the anticonvulsant zonisamide in the formalin test in mice

Takuhiro Murakami, Mitsuo Tanabe, Motoko Honda, Hideki Ono
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 202-202, 2005.

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Temporal and spatial patterns of microglia activation in the dorsal horn of neuropathic rats

Makoto Tsuda1), Shigeo Hasegawa2), Kazuhide Inoue1)2)
1)Div. Biosignaling, NIHS, 2)Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm., Kyushu. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 202-202, 2005.

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The analyses of the antinociceptive and rewarding effects of buprenorphine and tramadol in μ-opioid receptor knockout mice

Soichiro Ide1)2), Masabumi Minami3), George R. Uh14), Kumatoshi Ishihara1), Ichiro Sorai5), Kazutaka Ikeda2)
1)Lab. Neuropharmacol., Dept. Phamaceutical Sci., Hiroshima Int. Univ., 2)Dept. Mol. Psychiat., Tokyo Instit. Psychiat., 3)Dept. ol. Pharmacol., Facul. Pharmaceut. Sci., Kyoto Univ., 4)MNB, NIDA/IRP, 5)Dept. Neurosci., Div. Psychobiol., Tohoku Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 203-203, 2005.

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Supraspinal effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on nociceptive transmission in mice

Takao Shimizu, Keiko Imai, Noriko Iwatani, Kazuhiko Inoue, Hideki Sugawara, Atsuro Miyata
Dept. Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 203-203, 2005.

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Hyperglycemia in spinal cord contributes to mechanical hyperalgesia

Fumito Kobayashi, Kenji Honda, Sachi Nagaoka, Masako Koguchi, Ryo Saito, Yukio Takano
Dept. of Physiol. & Pharmacol., Fac. of Pharmaceut. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 203-203, 2005.

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Studies on vasopressin receptors in nociceptive perception using vasopressin receptor deficient mice

Sachi Nagaoka1), Kenji Honda1), Suguru Andou1), Fumito Kobayashi1), Takaaki Koshimizu3), Akito Tanoue2), Gozoh Tsujimoto3), Yukio Takano1)
1)Dept. Physiol. and Pharmacol. Fac. Pharmac. Sci., Fukuoka Univ., 2)Dept. Pharmacol., National Res. Inst. for Child, 3)Dept. Genomic Drug Discovery Sci., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 203-203, 2005.

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Antiallodynic effect and mechanism of Neurotropin(R) in L5 spinal nerve ligation model of neuropathic pain

Hiroyoshi Namba, Ryohei Okazaki, Hiroyuki Yoshida, Hisashi Okai, Kouji Koike, Tomoshi Miura, Minoru Kawamura
Inst. of Bio-Active Sci., Nippon Zoki Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 204-204, 2005.

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Both spinal nitric oxide-cGMP pathway and free radicals mediate maintenance of neuropathic pain in mice

Yoshinori Nagatani, Mitsuo Tanabe, Motoko Honda, Hideki Ono
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 204-204, 2005.

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Enhanced C-fiber-mediated wind-up following painful diabetic neuropathy in mice

Satoko Kimura1)2), Mitsuo Tanabe1), Motoko Honda1), Hideki Ono1)
1)Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2)Dept. Pharmacol., Fac. Pharm. Sci., Hokuriku Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 204-204, 2005.

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Antinociceptive effect of shakuyaku-kanzo-to in diabetic mice

Yuji Omiya, Kazuhiro Goto, Yasuyuki Suzuki, Yoshio Kase, Shuichi Takeda, Masaki Aburada
Tsumura Res. Inst., Medicinal Evaluation Lab.
Journal of Pharmacological Sciences 97 (suppl.2) 204-204, 2005.

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Studies on pain control system (Rept. 35): Neuropathic pain-like state increases anxiety-related behavior in mice

Chihro Kaneko1), Minoru Narita1), Michiko Narita1), Kiyomi Matsuzawa2), Mitsuaki Yamazaki2), Yoshinori Yajima1), Tsutomu Suzuki1)
1)Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2)Dept. Anesthesiol., Toyama Med. Pharmaceut. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 205-205, 2005.

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Descending serotonergic and noradrenergic mechanisms mediate taltirelin-induced analgesic effects on acute thermal and mechanical nociception, respectively

Yasushi Tokuda, Motoko Honda, Mitsuo Tanabe, Hideki Ono
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 205-205, 2005.

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Spinal lh channels mediate neuropathic pain

Mitsuo Tanabe, Keiko Takasu, Motoko Honda, Hideki Ono
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 205-205, 2005.

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Mechanisms of the antiallodynic effect of fluvoxamine in neuropathic pain mice

Kunitoshi Uchida, Motoko Honda, Mitsuo Tanabe, Hideki Ono
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 205-205, 2005.

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Studies on pain control system (Rept. 37): Involvement of spinal interleukin-6 in the development of neuropathic, but not inflammatory, pain in mice

Yoshinori Yajima, Minoru Narita, Chiharu Kubota, Mayumi Nakajima, Michiko Narita, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 206-206, 2005.

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Involvement of heme oxygenase in the protection of neuronal HT22 cells from oxidative stress

Asuka Kaizaki1), Sachiko Tanaka1), Kumiko Ishige2), Satoshi Numazawa1), Takemi Yoshida1)
1)Dept. Biochem. Toxicol., Sch. Pharmaceut. Sci., Showa Univ., 2)Dept. Pharmcol., Coll. Pharm., Nihon Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 206-206, 2005.

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Neuroprotective effect of minocycline on the cell death of retinal ganglion cells

Masamitsu Shimazawa1), Yasuhisa Oida1)2), Nobutaka Morimoto1)2), Hiroichi Nagai2), Hideaki Hara1)
1)Dept. Biofunct. Mol., Gifu Pharm. Univ., 2)Dept. Pharmacol., Gifu Pharm. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 206-206, 2005.

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Glial-derived neurotrophic factor inhibits threo-hydroxyaspartate-induced motor neuron death in organotypic spinal cord slice culture from G93A SOD1 transgenic mice

Kayo Nishida, Kumiko Ishige, Yoshihisa Ito
Dept. of Pharmacol., Coll. of Pharm., Nihon Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 206-206, 2005.

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Hydrogen sulfide enhances the activity of K+ and CI- channels to protect cellsfrom oxidative stress

Yuka Kimura1), Richard Dargusch2), David Schubert2), Hideo Kimura1)
1)Dept. Mol. Genetics, National Inst. of Neurosciece., NCNP, 2)The Salk Inst. for Biological Studies
Journal of Pharmacological Sciences 97 (suppl.2) 207-207, 2005.

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Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neurons

Toshiyuk Him
Dept Cell Signaling, Grad. Sch., Tokyo Med. Dent. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 207-207, 2005.

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Role of P13K-Akt pathway in response to endoplasmic reticulum stress-induced cell death

Kanae Hyoda1), Toru Hosoi1)2), Naohiro Horie1), Yasunobu Okuma1), Koichiro Ozawa2), Yasuyuki Nomura1)
1)Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Hokkaido Univ., 2)Dept. Pharmacother., Grad. Sch. Biomed. Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 207-207, 2005.

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Role of casein kinase 2 on endoplasmic reticulum stress responses

Naohiro Horie1), Toru Hosoi1)2), Kanae Hyoda1), Yasunobu Okuma1), Koichiro Ozawa2), Yasuyuki Nomura1)
1)Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Hokkaido Univ., 2)Dept. Pharmacother., Grad. Sch. Biomed. Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 207-207, 2005.

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Involvement of MAP kinase activation for the induction of Bip by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells

Akiko Yamamuro, Takashi Kishino, Rumiko Kuwada, Satoko Morita, Yasuhiro Yoshioka, Sadaaki Maeda
Dept. Pharmacotherap., Setsunan Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 208-208, 2005.

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Attenuation of neuronal damage by trimethyltin (TMT) in mice lacking PACAP (PACAP-KO)

Yoshiko Morita1), Daisuke Yanagida1), Norihito Shintani1), Kiyokazu Ogita2), Norito Nishiyama2), Hitoshi Hashimoto1), Akemichi Baba1)
1)Lab. Mol. Neuropharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2)Dept. Pharmacol., Setsunan Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 208-208, 2005.

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Behavioral changes by trimethyltin-induced dentate neural damage in mice

Chie Sugiyama, Sachiko Yamanouchi, Kiyokazu Ogita
Dept. Pharmacol., Setsunan Univ
Journal of Pharmacological Sciences 97 (suppl.2) 208-208, 2005.

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Enhanced expression of DJ-1 by trimethyltin-induced dentate neural damage in mice

Naoko Iwamoto1), Chie Sugiyama1), Takahiro Taira2), Hiroyoshi Ariga2), Kiyokazu Ogita1)
1)Dept. Pharmacol., Setsunan Univ., 2)Grad. Pharm. Sci. Hokkaido Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 208-208, 2005.

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Enhanced expression of doublecortin by TMT-induced dentate neural damage in mice

Norito Nishiyama, Chie Sugiyama, Kiyokazu Ogita
Dept. Pharmacol.
Journal of Pharmacological Sciences 97 (suppl.2) 209-209, 2005.

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Phosphorylation of ERK is involved in the protective effect of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia

Makiko Niimura1), Norio Takagi1), Keiko Takagi1), Kunio Matsumoto2), Toshikazu Nakamura2), Satoshi Takeo1)
1)Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm. Life Sci., 2)Div. Mol. Regenerative Med., Osaka Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 209-209, 2005.

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Roscovitine, a cyclin-dependent kinase inhibitor, reduces neuronal cell death induced by ischemia-reperfusion in the rat retina

Kenji Sakamoto, Kayo Ohki, Teppei Sakai, Maki Saito, Tsutomu Nakahara, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 209-209, 2005.

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Effects of pentosan polysulphate on the ischemia-related neuronal death in the hippocampus

Yasuko Sakurai-Yamashita, Yoshiko Masuda, Masami Niwa
Dept. Pharmacol. 1, Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 209-209, 2005.

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Cortical hypoperfusion and its possible mechanisms in an animal model for attention-deficit/hyperactivity disorder

Hiroko Togashi1), Subrina Jesmin2), Taku Yamaguchi1), Akiko Shibayama1), Ichiro Sakuma2), Ken-ichi Ueno1), Hitoshi Kakehata3), Mitsuhiro Yoshioka1)
1)Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. of Med., 2)Dept. Cardivascular Med., Hokkaido Univ. Grad. Sch. of Med., 3)Dept. Anesthesiol. & Critical Care Med., Hokkaido Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 210-210, 2005.

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Assessment of hyper accumulation around the lesion by FDG PET in primate thromboembolic stroke

Yuki Akiyoshi1), Teruo Susumu1), Tetsuya Yoshikawa1), Ryoichi Nagata1), Hiroshi Iwao2), Yasukatsu Izumi2), Go Kito1)
1)Shin Nippon Biomedical Laboratories (SNBL), Ltd., 2)Dept. Pharmacol., Osaka City Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 210-210, 2005.

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A monkey model of chronic stroke: Effects of rehabilitation

Hiroyuki Takamatsu1), Kaneyoshi Honjo2), Jin-Qing Hu2), Katsuya Shintaku2), Jin Hai Yue2), Yasuhiko Ikeda4), Yoshimi Misu3), Kazuo Umemura4)
1)Med. Pharmacol. Res. Centr. Found., 2)Honjo Biosci., Inc., 3)Shinobu Hosp., 4)Dept. Pharmacol. Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 210-210, 2005.

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Long-term effect of edaravone, a neuroprotective agent, on the functional outcome in a non-human primate model of stroke

Katsuya Shintaku1), Kaneyoshi Honjo1), Jin-Qing Hu1), Satoshi Yuki2), Hiroyuki Satoh2), Yoshimi Misu3)
1)Honjo Biosci., Inc., 2)Res. Lab. II, Mitsubishi Pharma Corporation, 3)Shinobu Hosp.
Journal of Pharmacological Sciences 97 (suppl.2) 210-210, 2005.

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Neuroprotective effects of KCL-440, a new poly(ADP-ribose)polymerase inhibitor, on a rat model of middle cerebral artery occlusion

Yasuhko Ikeda1), Kazuya Hokamura1), Kazunao Kondo1), Yasuhiro Suzuki1), Tomoyuki Kawai2), Tsuyoshi Anraku2), Takashi Uno2), Kazuo Umemura1)
1)Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2)Discovery Res. Lab., Kyorin Pharmaceuical Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 211-211, 2005.

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Screening for control genes in rat global cerebral ischemia using GeneChip system

Megum Kobayashi1), Yayoi Nishida2), Yasuo Takahashi2), Toshihito Nagata2), Satoshi Asai2), Koichi Ishikawa1)
1)Dept. Pharmacol., Nihon Univ. Sch. Med., 2)Div. Genomic Epidemiology & Clinical Trials., Nihon Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 211-211, 2005.

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Screening of control genes in mouse hippocampus after transient forebrain ischemia using high-density oligonucleotide array

Yayoi Nishida1), Megumi Kobayashi2), Toshihito Nagata1), Yasuo Takahashi1), Akiko Murata1), Satoshi Asai1)
1)Div. Genimic Epidemiology and clinical Trials, Nihon Univ. Sch. Med., 2)Dept. Pharmacol., Nihon Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 211-211, 2005.

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Relationship between angiogenesis and cell proliferation after transient forebrain ischemia in adult hippocampus

Nobuyuki Mochizuki, Norio Takagi, Takayuki Kawai, Kozue Sakanishi, Satoshi Takeo
Dept. Mol. Cell. Pharmacol., Tokyo. Univ. Pharm. Life Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 211-211, 2005.

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Acetyl-L-carnitine transport in rat astrocytes is mediated by the organic cation/carnitine transporter OCTN2

Masato Inazu, Hiroshi Takeda, Katsuyuki Maehara, Kyouji Miyashita, Teruhiko Matsumiya
Dept. Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 212-212, 2005.

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Effects of GLP-1 on LPS-induced cytokine expression in cultured astrocytes from the rat's cortex

Satoshi Ito, Takashi Iwai, Jun-Ichiro Oka
Lab. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 212-212, 2005.

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Effect of dibutyryl cyclic AMP on hydrogen peroxide-induced thymidine incorporation into cultured astrocytes

Koh-ichi Tanaka, Tomoaki Sato, Yoshiko Ohnishi, Nafees U. Chowdhury, Takashige Nishikawa
Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. & Dent. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 212-212, 2005.

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Effects of bifemelane hydrochloride on the intracellular Ca 24 level and ATP release of human origin clonal astrocytes

Yoshitoku Yoshda, Haruno Kumagai, Yoshihisa Kudo
Sch. Life Sci., Tokyo Univ. Pharm. & Life Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 212-212, 2005.

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Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes

Hiroshi Hibino1), Akikazu Fujita2), Kaori Iwai1), Mitsuhiko Yamada1), Yoshihisa Kurachi1)
1)Dept. Pharmacol. II, Grad. Sch. Med., Osaka Univ., 2)Dept. Veterinary Pharmacol., Grad. Sch. Agri. Life Sci., Osaka Pref. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 213-213, 2005.

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Single channel analyses of the inhibition of 5-HT-induced currents by cloperastine

Michitaka Shiozuka, Tetsuya Shirasaki, Kayo Hashitani, Fumio Soeda, Kazuo Takahama
Dept. Environ. & Molec. Health Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 213-213, 2005.

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The brain pericyte-derived transforming growth factor-beta (TGF-β) upregulates the blood-brain barrier function

Fuyuko Takata1), Shinya Dohgu1), Atsushi Yamauchi1), Noriko Sumi1), Shinsuke Nakagawa2), Masami Niwa2), Yasufumi Kataoka1)
1)Dept. of Pharmaceutical Care & Health Sci., Fac. of Pharmaceutical Sci., Fukuoka Univ., 2)Dept. of Pharmacol. 1, Nagasaki Univ. Grad. Sch. of Biomedical Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 213-213, 2005.

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Cyclosporin A induces dysfunction of the blood-brain barrier by inhibiting adrenomedullin signal transduction in mouse brain endothelial cells

Noriko Sumi1), Shinya Dohgu1), Atsushi Yamauchi1), Fuyuko Takata1), Shinsuke Nakagawa2), Masami Niwa2), Yasufumi Kataoka1)
1)Dept. Pharmaceut. Care and Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ., 2)Dept. of Pharmacol. 1, Nagasaki Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 213-213, 2005.

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Increase in aquaporin 1 expression by glucocorticoid in rat brain microvascular endothelial cells

Hideyuki Kobayashi, Toshihiko Yanagita, Hiroki Yokoo, Takashi Sugano, Shinya Satoh, Takayuki Nemoto, Akihiko Wada
Dept. Pharmacol., Univ. Miyazaki, Miyazaki Med. Coll.
Journal of Pharmacological Sciences 97 (suppl.2) 214-214, 2005.

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Manganese complexes of curcumin and diacetylcurcumin suppress NO production in the rat hippocampus: a microdialysis study

Yaowared Sumanont1), Yukihisa Murakami1), Michihisa Tohda1), Opa Vajragupta3), Hiroshi Watanabe1), Kinzo Matsumoto1)2)
1)Div. Medicinal Pharmacol., Inst. Natural Med., Toyama Med. & Pharm. Univ., 2)21st Century COE Program, Toyama Med. & Pharm. Univ., 3)Dept. Pharm. Chem., Faculty of Pharm., Mahidol Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 214-214, 2005.

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Effects of nicotine on nucleotides release from hippocampus in ovariectomized rats

Masumi Kobayashi, Yasushi Sakai
Div. of Physiol., Showa Univ., Sch. of Nursing & Rehabli.
Journal of Pharmacological Sciences 97 (suppl.2) 214-214, 2005.

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Effects of selegiline on antioxidant enzymes in the nigrostriatum in rat

Seiichiro Shimazu1), Kazue Takahata1), Hiroshi Katsuki2), Akinori Akaike2), Fumio Yoneda1)
1)Res. Inst., Fujimoto Pharmaceutical, 2)Dept. Pharmacol., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 214-214, 2005.

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Effect of edaravone on mitochondrial permeability transition pore in isolated rat brain mitochondria

Yuko Takayasu1), Tetsuo Fukushima2), Yoshimi Takegawa2), Hiroko Fujisaki1), Yutaka Koyama1), Akemichi Baba2), Toshio Matsuda1)
1)Lab. Medicinal. Pharmacol., Grad. Sch. Pharm. Sci., Osaka Univ., 2)Lab. Mol. Neuropharmacol., Grad. Sch. Pharm. Sci., Osaka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 215-215, 2005.

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T-817MA, a neurotrophic compound, protects against sodium nitroprusside-induced toxicity in rat primary cultured neurons

Tetsuo Fukushima1)3), Yuko Takayasu2), Toshio Matsuda2), Akemichi Baba1)
1)Lab. Mol. Neuropharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2)Lab. Med. Pharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 3)Toyama Chemical
Journal of Pharmacological Sciences 97 (suppl.2) 215-215, 2005.

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Altered level of glucocorticoid receptor within mitochondria by dexamethasone in murine brain

Yuhki Nakatani, Chie Sugiyama, Kiyokazu Ogita
Dept. Pharmacol., Setsunan Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 215-215, 2005.

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Strain-dependent susceptibility to mitochondrial complex I inhibitors in mouse mesencephalic cultures

Karo Tanaka, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 215-215, 2005.

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Influences of the mRNA expression of amyloid precurser protein and the related factors in primaly cultured cortex cells

Hisae Hayashi1), Michihisa Tohda1), Nuttawut Saelim1), Yukihisa Murakami1), Kinzo Matsumoto1)3)
1)Dept. Pharmacol., Inst. for Natl. Med., 2)Facl. Pharm. Sci., Naresuan Univ., 3)21th COE, Toyama Med. & Pharm. Univ
Journal of Pharmacological Sciences 97 (suppl.2) 216-216, 2005.

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F-1 isolated from a citrus fruit provides protection from memory impairment in Alzheimer's disease model rats

Kentarou Matsuzaki1), Michio Hashimoto2), Abdul Md Haque2), Yoshihiro Mimaki3), Yutaka Sashida3), Osamu Shido2), Tohru Yamakuni1), Yasushi Oizumi1)
1)Dept. Pharmacol., Tohoku Univ. Sch. Pharm., 2)Dept. Physiol., Shimane Univ. Sch. Med, 3)Lab. Plant Med., Tokyo Univ of Pharm., Sch. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 216-216, 2005.

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Protective effect of donepezil against amyloid-beta neurotoxicity in rat septal neurons

Manami Kimura, Shigeru Akasofu, Hiroo Ogura, Kohei Sawada
Eisai Tsukuba Res. Laboratories
Journal of Pharmacological Sciences 97 (suppl.2) 216-216, 2005.

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Effects of non-steroidal anti-inflamatory drugs on low-dose amyloid β-induced neurotoxicity in cultured rat hippocampal neurons

Kaori Kitagawa, Ryoichi Iwata, Nan-yan Zhang, Bo Wu, Zheng-Mei Xiong, Chiyoko Inagaki
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 216-216, 2005.

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([CI]i)-dependent amyloid β protein-induced glutamate neurotoxicity

Nan-yan Zhang, Kaori Kitagawa, Bo Wu, Tiesong Li, Chiyoko Inagaki
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 217-217, 2005.

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Protective effects of dihydrohonokiol-B against amyloid β protein-induced inhibition of neuronal CI--ATPase activity

Bing Liu, Naoki Hattori, Nan-yan Zhang, Kaori Kitagawa, Li Yang, Bo Wu, Yasuhisa Nakayama, Chiyoko Inagaki
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 217-217, 2005.

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Amyloid β (25-35)/glutamate induced apoptosis via PI3K/GSK-3 signaling pathway in human neuroblastoma cell line Yasuhisa Nakayama, Li Yang, Naoki Hattori

Yasuhisa Nakayama, Li Yang, Naoki Hattori, Chiyoko Inagaki
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 217-217, 2005.

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Search for calcineurin B binding proteins by yeast two-hybrid system

Miki Yoshida1), Makio Saeki2), Yuki Itsuki2), Yasuyuki Irie4), Yutaka Terao3), Shigetada Kawabata3), Shigeyuki Hamada3), Hitoshi Niwa1), Yoshinori Kamisaki2)
1)Dept. Dental Anesthesiology, Grad. Sch. Dent. Osaka Univ., 2)Dept. Pharmacol., Grad. Sch. Dent. Osaka Univ., 3)Dept. Oral and Mol. Microbiology., Grad. Sch. Dent. Osaka. Univ., 4)Dept. Pharmacol., Grad. Sch. Dent. Osaka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 217-217, 2005.

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Automated, highly sensitive and quantitative in situ hybridization system for mRNA expressed in a single glial cell

Akishige Ritani1), Nanae Nagata2), Yumiko Hoshikawa2), Shigeko Matsumoto2), Hiro Nitta3), Naomi Eguchi2)4)
1)Ventana Japan K.K., 2)Dept. Mol. Behav. Biol., Osaka Biosci. Inst., 3)Ventana Med. Systems Inc., 4)Adv. Res. Inst. for Biosci., Waseda Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 218-218, 2005.

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Analysis of MeCP2 expression in the central nervous system

Shigeo Uchino1), Moe Tsutsumi1), Takae Hirasawa1), Kaoru Nagai2), Takeo Kubota2), Shinichi Kohsaka1)
1)Dept. Neurochem., National Inst. of NeuroSci., 2)Dept. Epigenetic Med., Univ. Yamanashi
Journal of Pharmacological Sciences 97 (suppl.2) 218-218, 2005.

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Neuronal expression of cFos protein in the sensory and motor pathways of spermine synthase deficient mice

Mari Okazaki1), Naohiro Iwata1), Kanako Arai1), Yoshihiko Ikeguchi2), Tatsuhiro Usui1), Akira Shirahata2), Yasuhide Hibino1)
1)Lab. Immunobiochem., Fac. Pharmaceut. Sci., Josai Univ., 2)Dep. Biochem., Fac. Pharmaceut. Sci., Josai Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 218-218, 2005.

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V-1 regulation of actin dynamics via an inhibition of actin capping activity by association between and CapZ in PC12D cells

Masashi Kitazawa1), Tohru Yamakuni1), Si-Young Song2), Chieko Kato2), Yasushi Ohizumi1)
1)Dept. Pharm. Mol. Biol., Grad. Sch. Pharm. Sci. Tohoku Univ., 2)Mitsubishi Kagaku Insti. Life Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 218-218, 2005.

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Drebrin A inhibits the actin-binding activity of caldesmon

Ryoki Ishikawa, Akio Nakamura, Yuki Hanyuda, Kazuhiro Kohama
Dept. Mol. and Cell. Pharmacol., Gunma Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 219-219, 2005.

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Effects of PKC and its related kinase, PKN on tau degradation

Tomoko Kakehi, Taizo Taniguchi, Naoaki Saito
Lab. of Mol. Pharmacol., Biosignal Res. Ctr., Kobe Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 219-219, 2005.

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RTAs, monoclonal antibodies to tau protein block tau aggregation

Taizo Taniguchi1)2), Miho Sumida2), Shuko Hiraoka3), Koji Tomoo3), Tomoko Kakehi1), Shigeru Sugiyama4), Koji Inaka4), Toshimasa Ishida3), Naoaki Saito1)
1)Lab. of Mol. Pharmacol., Biosignal Res. Ctr., Kobe Univ., 2)Behavioral and Med. Sci. Res. Consortium, 3)Osaka Univ. of Pharmaceutical Sci., 4)Maruwa Food Industries, Inc
Journal of Pharmacological Sciences 97 (suppl.2) 219-219, 2005.

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Impaired cerebellar foiation of mice lacking kinase domain of FAK in nervous system

Furnihiro Watanabe1), Masahiro Fukaya2), Keiko Yamada2), Shigeru Noguchi3), Takanori Nomura1), Tomonori Takeuchi1), Hisashi Mori1), Masahiko Watanabe2), Kenji Sakimura4), Masayoshi Mishina1)
1)Dept. Mol. Neurobiol. & Pharmacol., Univ. Tokyo & SORST/JST, 2)Dept. Anat., Hokkaido Univ. Sch Med., 3)Meiji cell Technology Ctr., 4)Dept. Cell Neurobiol., Brain Res. Inst., Niigata Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 219-219, 2005.

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Expression of histone deacetylase Sir2α in neural stem cells of adult mouse brain

Shin Hisahara1), Takashi Hayashi2), Hiroyuki Matsumoto2), Yoshiyuki Horio1)
1)Dept. Pharmacol., Sapporo Med. Univ., 2)Dept. Neurology, Sapporo Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 220-220, 2005.

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Differential effects of stromal cells on neural differentiation of embryonic stem (ES) cells

Megumi Nakanishi, Megumi Hirose, Hitoshi Hashimoto, Akemichi Baba
Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 220-220, 2005.

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p38 MAPK associates stereoselective priming by grepafloxacin on 02- production in neutrophils

Masayuki Niwa1)2), Osamu Kozawa2), Masao Hirota3), Sadaki Fujimoto4)
1)MEDC, Gihu Univ. Sch. of Med, 2)Dept. Pharmacol., Gifu Univ. Sch. of Med., 3)Dept. of Drug Metabolism, Drug Safety Ctr., Otsuka Pharmaceutic. Co., Ltd., 4)Dept. Environment. Biochem., Kyoto Pharmaceutic. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 220-220, 2005.

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Comparison of the antioxidant activity of roasted tea with green, oolong, and black teas

Eiki Satoh1)2), Naoki Tohyama2), Masakazu Nishimura2)
1)Res. Cent. Animal Hyg. Food Saf., Obihiro Univ. Agric. Vet. Med., 2)Dept. Pathobiol. Sci., Obihiro Univ. Agric. Vet. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 220-220, 2005.

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Effect of the dosing time on ticlopidine-induced hepatotoxicity in male, female and ovariectomized mice

Ei Sejima, Atsushi Yamauchi, Shinya Dohgu, Yasufumi Kataoka
Dept. Pharm. Care Health Sci., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 221-221, 2005.

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Evaluation of various drugs in a rat hyperlipemia model using the diagnostic ultrasound system

Yuuichi Nishiyama, Ryouji Mizumachi, Kousuke Morizumi, Cheng-Jun Ma, Hiroshi Atai, Katsuhide Nishi
Dept. Pharmacol., Panapharm Laboratories Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 221-221, 2005.

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Recombinant human histidine rich glycoprotein domains expressed in E. coli

Hidenori Wake1), Shuji Mori1), Hideo Takahashi1), Yasuko Tomono2), Masahiro Nishibori1)
1)Dept. Pharmacol., Okayama Univ. Grad. Sch. Med. & Dent., 2)Shigei Med. Res. Inst.
Journal of Pharmacological Sciences 97 (suppl.2) 221-221, 2005.

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Human histidine rich glycoprotein binds to heme to inhibit the erythrolysis

Shuii Mori, Hidenori Wake, Hideo Takahashi, Masahiro Nishibori
Dept. Pharmacol., Okayama Univ. Grad. Sch. Med. & Dent.
Journal of Pharmacological Sciences 97 (suppl.2) 221-221, 2005.

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Hetero-oligomerization between purinergic receptors present in platelet membranes

Koshi Oyanagi, Toshio Kamiya, Hiroyasu Nakata
Dept. Mol. Cell Signling, Tokyo Met. Inst. Neurosci.
Journal of Pharmacological Sciences 97 (suppl.2) 222-222, 2005.

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Effect of cilostazol on expression of CD40L and CD40 on activated platelet surface

Hideki Ito, Yoshimi Hirose, Goro Miyakoda, Toyoki Mori
Res. Inst. of Pharmacological & Therapeutical Development, Otsuka Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 222-222, 2005.

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Nonsense-mediated mRNA decay of the intron-retained splice variant of GM-CSF receptor beta chain

Yayoi Shikama1)2), Tsutomu Shichishima2), Isao Matsuoka1)
1)Dept. Pharmacol., Fukushima Med. Univ., 2)1st Dept. Int. Med., Fukushima Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 222-222, 2005.

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Inhibitory action of daunorubicin on iNOS expression in macrophages

Fumiaki Saito, Satoshi Matsusaka, Hirohisa Kato, Ichiro Wakabayashi
Dept. of Hygiene & Preventive Med., Yamagata Univ. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 222-222, 2005.

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Distinction of sneeze and cough in guinea-pigs

Motomu Tanaka, Kei Maruyama
Dept. Pharmacol., Saitama. Med. Sch.
Journal of Pharmacological Sciences 97 (suppl.2) 223-223, 2005.

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A newly developed late asthmatic response-model in mice

Eiichi Araki, Kousuke Morizumi, Yasuo Nakamura, Hiroshi Atai, Katsuhide Nishi
Panapharm Laboratories Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 223-223, 2005.

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A new method to quantify the airway mucin content in bronchio-alveolar lavage fluid

Takashi Morikawa, Miaki Ariyoshi, Kosuke Morizumi, Matsuko Moriyasu
Panapharm Laboratories Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 223-223, 2005.

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Study on chronic obstructive pulmonary disease: Changes of the pulmonary function and lung histopathology in rats by cigarette smoke exposure

Jun-ichi Fuchikami1), Maki Matsuda1), Manami Chihara1), Akiharu Fujino1), Yoichiro Isohama2), Takeshi Miyata2)
1)Fuji Biomedix, Yamanashi, 2)Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharmac. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 223-223, 2005.

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Development of cigarette smoke solution (CSS) and lipopolysaccharide (LPS)-induced emphysema in guinea pigs

Nobuaki Mizutani1), Jun-ichi Fuchikami2), Maki Matsuda2), Mitsuteru Ishiwara1), Ayako Otsuka1), Kazumi Suetake1), Hidetsugu Takagaki1)
1)Dainippon Ink and Chemicals, Incorporated, 2)Fuji Biomedix Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 224-224, 2005.

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Effects of various drugs on the electrically evoked cough reflex in conscious dogs

Tadashi Tsubouchi, Shinji Tsujimoto, Terumasa Mino, Takaki Seki
Environmental Health Sci. Lab., Sumitomo Chemical Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 224-224, 2005.

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YM-58483, a selective CRAC channel inhibitor, prevents late-phase asthmatic responses through Th2 cytokine inhibition in animal models

Taiji Yoshino, Jun Ishikawa, Keiko Ohga, Tatsuaki Morokata, Ryuichi Takezawa, Toshimitsu Yamada, Masao Sasamata, Keiji Miyata
Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 224-224, 2005.

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Ovariectomy aggravates hypersensitivity reactions to paclitaxel in rats

Takeshi Goromaru1), Kenji Kobayashi1), Toshiaki Sendo2), Yoshinori Itoh1)2), Ryozo Oishi1)2)
1)Grad. Sch. Pharmac. Sci. Kyushu Univ., 2)Dept. Pharm., Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 97 (suppl.2) 224-224, 2005.

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Pharmacological studies on the respiratory tract (Rept. 266): Transcriptional factors involved in the bronchial smooth muscle hyperresponsiveness in rat allergic asthma

Mayu Hirahara, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Dept. Pharmacol., Sch. Pharm., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 225-225, 2005.

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Pharmacological studies on the respiratory tract (Rept. 267): Contribution of NO to leukotriene D4-induced venodilation of nasal septal mucosa in nasal hyperresponsive rats

Michiko Oshita, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Dept. Pharmacol., Sch. Pharm., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 225-225, 2005.

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Pharmacological studies on the respiratory tract (Rept. 269): New method for measuring venous response in mice nasal septal mucosa in vivo by stereomicroscopy

Yuki Satoh, Michiko Oshita, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Dept. Pharmacol., Sch. of Pharm., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 225-225, 2005.

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Effects of new developed Chinese medicine on anti-asthma treatment in rats

Mao-Lin Ho1), Hung-Che Shih1), Chia-Yuh Cheng1), Peng-Fei Wang1), Ching-Yi Lee1), Yu-Ping Chang1), Bai-Jiun Tu2), Chin-Lang Hsieh1), Ming-yung Chou1)
1)Inst. of Med. of Chung-Shan Med. Univ., 2)Natuonal Taichung Inst. of Technology
Journal of Pharmacological Sciences 97 (suppl.2) 225-225, 2005.

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Effects of terpene alcohols, bisabolol and menthol, on the tracheal smooth muscle

Toru Kawasuji, Toshiyuki Matsubara, Hideyo Suzuki
Toyama Pref. Inst. for Pharm. Res.
Journal of Pharmacological Sciences 97 (suppl.2) 226-226, 2005.

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Regulation of K+channel expression and K+ current by hypoxia in alveolar epithelial cells

Toshihiro Konno1), Kazuhiro Ogawa1), Haruko Masumiya1), Masahiko Takahashi2), Teruyuki Yanagisawa1)
1)Dept. Mol. Pharmcol., Tohoku Univ. Grad. Sch. Med., 2)Dept. Dent-Oral Anesthesiol., Tohoku Univ. Grad. Sch. Dent.
Journal of Pharmacological Sciences 97 (suppl.2) 226-226, 2005.

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The roles of mast cells in compound 48/80 induced asthmatic respose

Shuang Liu, Kazutaka Maeyama
Dept. Pharmacol., Ehime univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 226-226, 2005.

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Involvemant of Rho signaling in PAR-2-mediated increase in neutrophil adhesion to alveolar epithelial cells

Yasuhiro Yagi1), Seijitsu Andoh1), Hitomi Otani1), Akihiro Oshiro1), Kenzo Kawai2), Hiroyuki Nishikawa2), Hiromasa Araki2), Chiyoko Inagaki1)
1)Dept. Pharmacol., Kansai Med. Univ., 2)Res. Dev. Ctr., Fuso Pharmaceu. Ind. Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 226-226, 2005.

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Induction of apoptosis and phosphorylation of H2B histone by the extracts of Sea buckthorn (Hippophae rhamnoides) seeds in Jurkat & HL-60 cells

Yasuo Kizawa1), Minori Furuya1), Susumu Kitanaka2), Tadashi Kusama1)
1)Dept. Physiol. & Anat., Nihon Univ. Coll. Pharm., 2)Lab. Pharmacog. & Nat. Prod. Chem.
Journal of Pharmacological Sciences 97 (suppl.2) 227-227, 2005.

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Possible correlation between MUC1 and TLR5

Akinori Hisatsune1)2), Erik P. Lillehoj2), Yoichiro Isohama1), Takeshi Miyata1), Kwang Chul Kim2)
1)Dept. Chemico-Pharmacological Sci., Faculty of Med. and Pharmaceutical Sci., Kumamoto Univ., 2)Univ. Maryland Sch. Pharm
Journal of Pharmacological Sciences 97 (suppl.2) 227-227, 2005.

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Cellular signaling and induction of cyclooxygenase-2 caused by proteinase-activated receptor-2 (PAR-2) activation in human lung epithelial cells

Mami Nagataki1), Naoyuki Kawao1), Keita Nagasawa1), Kelly Cushing2), Fumiko Sekiguchi1), Wallace K. MacNauguton2), Morley D. Hollenberg2), Hiroyuki Nishikawa3), Hiromasa Araki3), Atsufumi Kawabata1)
1)Div. Physiol. Pathophysiol., Sch. Pharmaceut. Sci., Kinki Univ, 2)Dept. Pharmacol. Ther., Fac. Med., Univ., 3)Res. Dev. Ctr., Fuso Pharmaceu. Ind. Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 227-227, 2005.

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Crystalographic and pharmacological characterrization of HQL-79 as an orally active inhibitor for human hematopoietic prostaglandin D synthase

Kosuke Aritake1), Yuji Kado2), Tsuyoshi Inoue2), Osamu Hayaishi1), Yoshihiro Urade1)
1)Dept. Mol. Behav. Biol., 2)Material Chem., Grad. Sch. of Eng., Osaka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 227-227, 2005.

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Cytokine regulation of CysLT1 and CysLT2 receptor expression in the human monocytic leukemia cell line THP-1 cells

Mariko Domae, Yuichiro Kamikawa
Dept. Pharmacol., Dokkyo Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 228-228, 2005.

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Suppression of IgE-mediated TNF-α mRNA expression in heme oxygenase-1-induced RBL-2H3 cells

Yumiko Yasui, Masaru Sakata, Nobuaki Matsui, Nobuyuki Fukuishi, Masaaki Akagi
Fac. of Pharmacol. Sci., Tokushima Bunri Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 228-228, 2005.

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Stimulatory effects of growth hormone on the differentiation of mouse B-lymphoid precursors

Kiminobu Sumita, Naoki Hattori, Chiyoko Inagaki
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 228-228, 2005.

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Effect of tributyrin on oral tolerance

Kouya Yamaki, Noriko Kanamaru, Makika Koike, Mihoko Mori, Shin Yoshino
Dept. Pharmacol., Kobe Pharmaceutical Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 228-228, 2005.

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M1 and M4, active components of ginseng saponin metabolites, promote maturation of dendritic cells and drive a potent Th1 polarization in vitro

Eiichi Tachikawa1), Masao Takei2), Hideo Hasegawa3), Kenzo Mizuma1), Kenzo Kudo1), Yukiko Kondo1), Eiichi Taira1)
1)Dept. Pharmacol., Sch. Med., Iwate Med. Univ., 2)Div. of Cell. Allergol., Res. Ctr. Borstel, 3)Fermenta Herb Inc.
Journal of Pharmacological Sciences 97 (suppl.2) 229-229, 2005.

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Characterization of mouse chymase

Yoshinori Iba, Haruka Murai, Sayuri Okamoto, Tohru Masukawa
Dept. Clin. Biochem., Fac. Pharm. Sci., Setsunan Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 229-229, 2005.

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Maintenance of cultured rat peritoneal mast cells via kit signal

Nurul Hiedayati, Kazutaka Maeyama
Dept. Parmacol., Ehime Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 229-229, 2005.

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Heterologous autonomic regulation of histamine H1 receptor signaling

Katsuhiro Miyoshi, Shuhei Horio, Hiroyuki Fukui
Dept. of Mol. Pharmacol., The Univ. of Tokushima, Inst. of Health Biosci.
Journal of Pharmacological Sciences 97 (suppl.2) 229-229, 2005.

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Expression of COX-2 in dendritic cells of draining lymph nodes in rat carrageenin-induced pleurisy

Masashi Nakano1), Michiko Kawamura2), Ko Hatanaka2), Yoshiteru Harada1)
1)Dept. Mediator and Signal Transduction Pharmacol., Kitasato Univ. Grad. Sch. of Med. Sci., 2)Dept. Pharmacol., Kitasato Univ. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 230-230, 2005.

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Inhibitory action of ethanol on ERK-mediated COX-2 expression in rat alveolar macrophages

Hirohisa Kato, Munetaka Negoro, Ichiro Wakabayashi
Dept. of Hygiene & Preventive Med., Yamagata Univ. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 230-230, 2005.

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Phorbol 12-myristate-13-acetate (PMA) increases choline acetyltransferase (ChAT) activity in human leukemic T cell line MOLT-3

Kazuto Masuyama, Takeshi Fujii, Koichiro Kawashima
Dept. Pharmacol., Kyoritsu Col. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 230-230, 2005.

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Studies on regulation of lymphocytic cholinergic activity via DP receptor (DPR)-mediated pathways in MOLT-3 cells, using BW245C and ONO-PM-1 82

Yukiko Sugita, Aya Suenaga, Takeshi Fujii, Koichiro Kawashima
Dept. Pharmacol., Kyoritsu Coll. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 230-230, 2005.

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Murine antigen-presenting cells express various subtypes of muscarinic and nicotinic acetylcholine receptor genes

Junichi Watanabe, Takesi Fujii, Koichiro Kawashima
Dept. Pharmacol., Kyoritsu Coll. of Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 231-231, 2005.

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Effects of chronic nicotine (Nc) exposure on antibody production and nAChR α7 subunit gene expression in mononuclear leukocytes (MNLs) of BALB/c mice

Ayako Tashiro, Kumiko Arimoto, Takeshi Fujii, Koichiro Kawashima
Dept. Pharmacol., Kyoritsu Coll. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 231-231, 2005.

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Lymphocytic cholinergic activity in senescence-accelerated mouse (SAM) with immune deficiency

Kumiko Arimoto, Kazuko Fujimoto, Takeshi Fujii, Koichiro Kawashima
Dept. Pharmacol., Kyoritsu Coll. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 231-231, 2005.

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Potent inhibition of B cell receptor calcium signaling by novel pyrazole derivatives

Shigeki Kiyonaka1), Motohiro Nishida2), Takuma Kamikawa1), Takahumi Miki1), Kenta Kato1), Takeshi Mizumoto1), Takuro Numaga1), Emiko Mori1), Masakazu Ishii3), Tsutomu Kobayashi4)
1)Dept. Synth. Biol. Chem., Grad. Sch. Engin., Kyoto Univ., 2)Grad. Sch. Pharmaceut, Sci., Kyushu Univ., 3)Sch. Pharmaceut. Sci., Showa univ., 4)Tanabe Seiyaku Co. Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 231-231, 2005.

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Physiological role and activation mechanism of the oxidative stress-susceptible TRPM2 Ca2+, channel in immunocytes

Shinichiro Yamamoto1)2), Shunichi Shimizu2), Masakazu Ishii2), Tamio Hagiwara2), Yuji Hara1), Takaharu Negoro2), Motohiro Nishida1), Takashi Tobe2), Yuji Kiuchi2), Yasuo Mori1)
1)Dept. of Synth. and Biol. Chem., Kyoto Univ., 2)Dept. of Pathophysiol., Sch. of Pharm. Sci., Showa Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 232-232, 2005.

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Analysis of BCR-induced calcium signaling in TRPC3-deficient DT40 cells

Takuro Numaga1), Keiji Imoto1), Yasuo Mori2)
1)Dept. Physiol. Sci., Sch. Life Sci., Grad. Sch. Adv. Studies, 2)Dept. Synth. Biol. Chem., Grad. Sch. Engineering, Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 232-232, 2005.

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Comparison study between the mechanisms of allergic asthma amelioration by a cysLT1R antagonist and steroid

Akira Murai1), Masayoshi Abe2), Yuri Hayashi1), Naomi Shimizu2), Keiichi Tanaka1), Takeshi Katsuragi2)
1)Crit. Care & Emergency Med., Fukuoka Univ., 2)Dept. Pharmacol., Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 232-232, 2005.

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The beneficial or detrimental effects of an inducible NO synthase (iNOS) inhibitor on allergic airway inflammation depending on its administration schedule

Masayoshi Abe1), Naomi Shimizu2), Yuri Hayashi1), Kazuhiko Shibata2), Rie Igarashi3), Takeshi Katsuragi1)
1)Dept. Pharmacol., Fukuoka Univ. Sch. Med., 2)Labo. Biodyna., Fukuoka Univ. Sch. Med., 3)2nd Dept. St. Marianna Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 232-232, 2005.

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Cytoprotective effect of nitric oxide against hydrogen peroxide toxicity is mediated through the induction of catalase in RAW264 cells

Yasuhiro Yoshoka, Tatsuya Kitao, Takashi Kishino, Akiko Yamamuro, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 233-233, 2005.

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Activation of p38 MAP kinase induces conformational change of Bax in hydrogen peroxide-induced apoptosis in RAW264 cells

Tatsuya Kitao, Yasuhiro Yoshioka, Akiko Yamamuro, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 233-233, 2005.

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Inhibition by Moxa smoke of prostaglandin E2 production in the activated macrophage-like cell line

Ken Hashimoto1), Hisatoshi Matsumoto2), Jun Shimada2), Hiroshi Sakagami1)
1)Dept. Dental Pharmacol., Meikai Univ. Sch. Dent., 2)First Dept. Oral Maxllofac Surg., Meikai Univ. Sch. Dent.
Journal of Pharmacological Sciences 97 (suppl.2) 233-233, 2005.

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GLP (Good Laboratory Practice) for new drug application in Japan

Tamiko Suzuki-Nishimura
Pharmaceuticals and Med. Devices Agency
Journal of Pharmacological Sciences 97 (suppl.2) 233-233, 2005.

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Modelling of the voltage-dependent inactivation process of L-type Ca2+, channel

Shingo Suzuki1), Chiaki Tsuchikawa1), Ian Findlay2), Yoshihisa Kurachi1)
1)Dept. Pharmacol., Osaka Univ. Grad. Sch. Med., 2)Facultedes Sci., Universite de Tours
Journal of Pharmacological Sciences 97 (suppl.2) 234-234, 2005.

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Role of gonadal steroids on calcium currents for sex differences in guinea pig cardiac muscles

Satoko Ichisaki, Shin-ichi Nagayama, Kiyokazu Yunomae, Junko Matuo, Mihori Haruyama, Koichiro Fukuzaki, Ryoichi Nagata, Go Kito
Shin Nippon Biomedical Laboratories, Ltd (SNBL)
Journal of Pharmacological Sciences 97 (suppl.2) 234-234, 2005.

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63 The R(-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea-pig ventricular myocardium

Chisa Komikado1), Hideaki Shimada1), Kentaro Takeda1), Iyuki Namekata1), Toru Kawanisi2), Hikaru Tanaka1), Koki Shigenobu1)
1)Dept. Pharmacol., Toho Univ. Sch. Pharmaceut. Sci., Chiba, 2)Div. Biol. Chem. Biol., Natl. Inst. Health Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 234-234, 2005.

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Effects of isoflurane on ATP-sensitive K+ channels reconstituted in HEK293 cells

Hisanori Fujita, Takehiko Ogura, Haruaki Nakaya
Dept. Pharmacol., Chiba Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 234-234, 2005.

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Phosphorylation-independent modulation of a heart potassium channel by the A kinase-anchoring protein Yotiao

Junko Kurokawa1)2), Howard K. Motoike2), Jenny Rao2), Robert S. Kass2)
1)Dept. Bio-informational Pharmacol., MRI, Tokyo Med. & Dent. Univ., 2)Dept. Pharmacol., Columbia Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 235-235, 2005.

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Famotidine neither inhibits HERG K+ current nor affects action potential parameters

Atsushi Sugiyama1)2), Shigekazu Shimizu2)3), Akira Takahara1)2), Yasuki Akie2)3), Yasue Sakaguchi1)3), Keitaro Hashimoto1)
1)Dept. Pharmacol., Univ. of Yamanashi, 2)Yamanashi Res. Ctr. of Clin. Pharmacol., 3)Fiji Biomedix
Journal of Pharmacological Sciences 97 (suppl.2) 235-235, 2005.

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NIP-142 inhibits human GIRK1/4 current more potently than HERG current

Noriko Tsuruoka1), Mie Ito1), Sayoko Ishimaru1), Tokiko Aikawa1), Naoko Iida-Tanaka2), Tomoyuki Matsuda3), Toru Yamashita3), Nobutomo Tsuruzoe3), Hikaru Tanaka1), Koki Shigenobu1)
1)Dept. Pharmacol., Toho Univ. Sch. Pharmaceut. Sci., 2)Dept. Food Sci., Otsuma Woman's Univ., 3)Biol. Res. Lab., Nissan Chemical Industries, Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 235-235, 2005.

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Investigation of the block and facilitation effects by nifekalant in a HERG channel

Yukio Hosaka1), Mitsuhiko Yamada2), Masaru Ishii1), Yoshihisa Kurachi1)
1)Dept. Pharmacol., Osaka Univ. Sch. Med., 2)Dept. Pharmacol., Shinshu Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 235-235, 2005.

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Effects of changes in extracellular pH and potassium concentration on hERG current

Wen-ge Yu, Kana Kimura, Eri Noguchi, Cheng-jun Ma, Naoki Watanabe, Mariko Yamaguchi, Masakazu Imaizumi, Hiroshi Atai, Katsuhide NIshi
Div. of Pharmacol., Panapharm Laboratories Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 236-236, 2005.

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Difference of inhibitory effects on HERG potassium channel transfected in HEK 293 and CHO-K1 cells

Shigekazu Shimizu, Yoshiyasu Takahashi, Misako Nakamura, Akiharu Fujino
Pharmacol. Res. Lab., Fuji Biomedix Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 236-236, 2005.

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The inter-cell-line reproducibility of hERG assay using the whole-cell patch-clamping

Yoshimi Katayarma, Tomoko Tsuzaki, Kanae Abe, Satomi Tomizawa, Taku Izumi, Yuji Tsurubuchi
Pharmacological Res. Laboratories, Drug Safety Testing Ctr. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 236-236, 2005.

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Determination of IC5o values for hERG blockers using an automated patch-clamp screening system

Kenji Tsuzaki1), Niels J. Willumsen2)3), M Sunesen3), Yuji Tsurubuchi1)
1)Pharmacological Res. Laboratories, Drug Safety Testing Ctr. Co., Ltd., 2)Sophion Biosci., 3)August Krogh Inst., Univ. of Copenhagen
Journal of Pharmacological Sciences 97 (suppl.2) 236-236, 2005.

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Compound adsorption and the prevention measure in the automated patch-clamp assay

Naoto Hongo, akayuki Fujita, Masato Nakajima, Shiori Takahashi, Yuji Tsurubuchi
Pharmacological Res. Laboratories, Drug Safety Testing Ctr. Co., Ltd
Journal of Pharmacological Sciences 97 (suppl.2) 237-237, 2005.

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Molecular identification and functional analysis of small-conductance Ca2+-activated K+ channel in rat heart

Takamitsu Soma1), Mitsuhiro Fukao2), Ichiro Sakuma1), Kazuhiko Nagai1), Satoshi Nawate1), Jesmin Subrina1), Naomasa Makita1), Osamu Takikawa3), Noritsugu Tohse2), Akira Kitabatake1), Soichi Miwa3)
1)Dept. Cardiovasc. Med., Hokkaido Univ. Sch. Med., 2)Dept. Phys., Sapporo Med. Univ. Sch. Med., 3)Dept. Pharmacol., Hokkaido Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 237-237, 2005.

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Identification of a novel specifec modulator of the L-type Ca2+, channel CaV1.2

Isao Naguro1), Susumu Minamisawa2), Yoshitake Nishimune3), Hidenori Ichijo1), Satomi Adachi-Akahane1)
1)Grad. Sch. Pharmaceut. Sci. Lab. Cell Signaling, Univ. Tokyo, 2)Dept. Physiol. Yokohama City Univ., 3)Osaka Univ. Res. Inst. for Microbial. disease, Dept. Sci. Lab. Animal Exp.
Journal of Pharmacological Sciences 97 (suppl.2) 237-237, 2005.

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TRPC5 is activated by endogenous NO through direct cystein oxidation

Takashi Yoshida1), Yuriko Iinuma1), Motohiro Nishida2), Yuji Hara1), Yasuo Mori1)
1)Dept. Synth. Biol. Chem., Facult. Engineer., Kyoto Univ., 2)Lab. Phar. & Toxicol., Grad. Sch. Pharmaceu. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 237-237, 2005.

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Up-reguration of TRP channels in hypertrophied myocardium

Takayoshi Ohba1), Manabu Murakami2), Hiroyuki Watanabe1), Yoichiro Takahasi1), Kyoichi Ono2), Toshihiko Iijima2), Hiroshi Ito1)
1)Second Dept. Internal Med., Akita Univ. Sch. Med., 2)Dept. Pharmacol., Akita Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 238-238, 2005.

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Genomic organization and functional analysis of murine PKD2L1

Manabu Murakami1), Takayoshi Ohba2), Feng Xu1), Seiji Shida1), Eisaku Satoh3), Kyoichi Ono1), Hiroyuki Watanabe2), Hiroshi Ito2), Toshihiko Iijima1)
1)Dept. Pharmacol., Akita Univ. Sch. Med, 2)Second Dept. Internal Med., Akita Univ. Sch. Med, 3)Dept. Pharmacol., Aomori Univ. Sch. Pharmacol.
Journal of Pharmacological Sciences 97 (suppl.2) 238-238, 2005.

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Inhibitory effect of a novel benzyloxyphenyl derivative, SN-6 on Na+/Ca2+ exchange current in single guinea-pig cardiac ventricular myocytes

Chun-Feng Niu1), Yasuhide Watanabe2), Takahiro Iwamoto3), Hiroshi Sato1), Hajime Terada1), Hideharu Hayashi1), Junko Kimura4)
1)Dept. Internal Med. III, Hamamatsu Univ. Sch. Med., 2)Dept. Pathophysiol., Basic Nrs., Sch. Med., Hamamatsu Univ., 3)Dept. Pharmacol., Sch. Med., Fukuoka Univ., 4)Dept. Pharmacol., Sch. Med., Fukushima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 238-238, 2005.

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Involvement of Rho-GTPase in Na+/Ca2+ exchanger mRNA stability in H9c2 cells

Sachiko Maeda1), Isao Matsuoka1), Takahiro Iwamoto2), Hitoshi Kurose3), Junko Kimura1)
1)Dept. Pharmacol., Sch. Med., Fukushima Med. Univ., 2)Dept. Pharmacol., Sch. Med., Fukuoka Univ., 3)Dept. Pharmacol. Toxicol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 238-238, 2005.

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Molecular cloning of the protein interacting with heart-restricted leucine-rich repeat protein, HRLRRP

Tokio Nakane, Yoichi Inada, Mitsuhiko Yamada
Dept. Mol. Pharmacol., Shinshu Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 239-239, 2005.

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New evaluation of cardiac function in primate by real-time three-dimensional echocardiography as novel tools and methods for drug development

Haruno Yonamne1), Hideshi Tsusaki1), Asako Tamai1), Mutsuko Shimomoto2), Ryoichi Nagata1), Go Kito1)
1)Shin Nippon Biomedical Laboratories, Ltd. (SNBL), 2)Philips Med. Systems Corporation (PHILIPS)
Journal of Pharmacological Sciences 97 (suppl.2) 239-239, 2005.

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Ex vivo application of ESR spectroscopy in Langendorff guinea-pig heart preparations

Michio Yajima, Tatsuya Muto, Lei Huang, Yosihiro Hotta, Naohisa Ishikawa
Dept. Pharmacol., Aichi Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 239-239, 2005.

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A new monophasic action potential (MAP) recording system for the Langendorff-perfused heart

Yuji Nakamura, Atsushi Sugiyama, Akira Takahara, Sachiko Honsho, Keitaro Hashimoto
Dept. Pharmacol., Univ. of Yamanashi
Journal of Pharmacological Sciences 97 (suppl.2) 239-239, 2005.

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Accurate evaluation of QT interval in conscious cynomolgus monkeys by use of telemetry ECG

Motoki Hijioka, Koichi Kuwano, Tatsuya Jikuzono, Shohei Otsuka, Tomoko Miyake, Tsuyoshi Uchino, Mayumi Shoki, Tadashi Koga, Koichiro Fukuzaki, Ryoichi Nagata, Go Kito
Shin Nippon Biomedical Laboratories, Ltd. (SNBL)
Journal of Pharmacological Sciences 97 (suppl.2) 240-240, 2005.

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Monophasic action potential (MAP) recording with ventricular pacing is more reliable method than QTc measurement for the risk prediction of drug-induced QT prolongation in vivo

Kentaro Ando1)2), Atsushi Sugiyama2), Hiroyuki Harada1), Hiroyoshi Miyamoto1), Masanori Kobayashi1), Kyoko Kato1), Yoshifumi Uno1), Keitaro Hashimoto2)
1)Toxicology Lab., Mitsubishi Pharma. Co., 2)Dept. Pharmacol., Univ. of Yamanashi
Journal of Pharmacological Sciences 97 (suppl.2) 240-240, 2005.

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Chronic atrioventricular block dogs as a model for predicting drug-induced torsades de pointes

Yasuki Akie1)2), Masaru Sugiyama1), Yoshiki Tate1), Yoshinori Ishiyama1), Fumio Masaki1), Akiharu Fujino1), Atsushi Sugiyama2)
1)Fuji Biomedix, 2)Dept. Pharmacol., Univ. of Yamanashi
Journal of Pharmacological Sciences 97 (suppl.2) 240-240, 2005.

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Characterization of halothane-anesthetized guinea pigs as a model to assay the drug-induced QT prolongation

Yasue Sakaguchi1)2), Atsushi Sugiyama1), Shuji Takao2), Yasuki Akie2), Akira Takahara1), Keitaro Hashimoto1)
1)Dept. Pharmacol., Univ. of Yamanashi, 2)Fuji Biomedix
Journal of Pharmacological Sciences 97 (suppl.2) 240-240, 2005.

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A Further study on evaluation of drugs inducing QT-interval prolongation by ECG recorded from the isolated guinea-pig perfused heart paced at the constant heart rate.

Atsuko Kato, Masakazu Imaizumi, Hiroshi Atai, Hiromi lizuka, Katsuhide Nishi
Panapharm Laboratories Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 241-241, 2005.

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Recording mono-phasic action potentials (MAP) from the surface of the anesthetized guinea-pig heart to evaluate drugs inducing QT-interval prolongation

Keiko Azuma
Dept. Pharmacol., Panapharm Laboratories Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 241-241, 2005.

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Anti-atrial fibrillatory profile of NIP-151, a novel agent that selectively prolongs atrial effective refractory period

Norio Hashimoto, Tomoyuki Matsuda, Ryo Matsumoto, Toru Yamashita, Norihisa Ishiwata, Nobutomo Tsuruzoe
Biological Reserch Laboratories, Nissan Chemical Industries, Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 241-241, 2005.

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Effects of SEA0400, a novel sodium-calcium exchange inhibitor, on ouabain-induced arrhythmias in guinea pigs

Amran Mohammad-Shah, Nobuo Homma, Keitaro Hashimoto
Dept. Pharmacol., Interdisciplinary Grad. Sch. of Med. and Engineering, Univ. of Yamanashi
Journal of Pharmacological Sciences 97 (suppl.2) 241-241, 2005.

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Blebbistatin blocks PDGF-induced migration of vascular smooth muscle cells

Xiaoran Qin1), Tiejun Zhao2), Lihong Ye2), Hideyuki Tanaka1), Akio Nakamura1), Kazuhiro Kohama1)
1)Dept. Mol. Cell. Pharmacol., Gunma Univ. Grad. Sch. Med., 2)Coll. of Life Sci., Nankai Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 242-242, 2005.

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Effect of non-kinase activity of myosin light chain kinase (MLCK) on smooth muscle myosin and its fragment

Mingli Liang1)2), Ying Gao2), Keiko Arai1), Akio Nakamura1), Kazuhiro Kohama1)
1)Dept. Mol. Cell. Pharmacol., Gunma Univ. Grad. Sch. Med., 2)Dept. Biochem., Dalian Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 242-242, 2005.

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High-level expression of a soluble and active form of full-length smooth muscle MLCK using cold-shock vector in Escherichia coli

Akio Nakamura, Yuki Hanyuda, Kazufumi Kawano, Kazuhiro Kohama
Dept. of Mol. and Cell. Pharmacol., Faculty of Med., Gunma Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 242-242, 2005.

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Identification of gap-junction in rat smooth muscle tissues

Hideyuki Tanaka1)2), Kazuhiro Kohama2)
1)Dept. Res. Sci., Gunma Univ. Sch. Med., Maebashi, 2)Dept. Mole. and Cell., Pharmacol., Gunma Univ. Grad., Sch. Med., Maebashi
Journal of Pharmacological Sciences 97 (suppl.2) 242-242, 2005.

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A conceivable role in ATP release evoked by neurokinin A via Ins(1,4,5)P3 sensitive-Ca2+, signaling from taenia coli smooth muscle cells

Takeshi Katsuragi1), Chiemi Sato1), Sadaharu Usune2), Kenji Honda3), Keisuke Migita1)
1)Dept. Pharmacol., Sch. Med., Fukuoka Univ., 2)Res. Lab. Biodynam., Sch. Med., Fukuoka Univ., 3)Dept. Physiol. and Pharmacol., Fac. Pharmaceut. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 243-243, 2005.

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A smooth muscle relaxant extracted from Physarum polycephalum

Shinji Yoshiyama1), Kouji Nagata2), Akio Nakamura1), Masaru Tanokura2), Kazuhiro Kohama1)
1)Dept. Mol. Cell. Pharmacol., Gunma Univ. Grad. Sch. Med., 2)Grad. Sch. of Agric. Life Sci., Univ. of Tokyo
Journal of Pharmacological Sciences 97 (suppl.2) 243-243, 2005.

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Distribution of histamine H2-receptor and its participation in contraction in rat blood vessels

Hong-Lan Piao, Tatsuru Tsurumaki, Tsuyoshi Yamaguchi, Hiroshi Higuchi
Div. Pharmacol., Grad. Sch. Med. Dent. Sci., Niigata Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 243-243, 2005.

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The effects of aging on ,α1-adrenoceptor mechanisms in isolated mouse aortic preparation

Fumiko Yamaki, Yoshio Tanaka, Katsuo Koike
Dept. Chem. Pharmacol., Toho Univ. Sch. Pharmaceu. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 243-243, 2005.

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Relaxant effects of docosahexaenoic acid (DHA) on the vascular contractions in rat and guinea-pig arteries

Kazuoki Otsuka1), Yoshio Tanaka2), Hikaru Tanaka1), Katsuo Koike2), Koki Shigenobu1)
1)Dept. Pharmacol., Toho Univ. Sch. Pharmaceu. Sci., 2)Dept. Chem. Pharmacol., Toho Univ. Sch. Pharmaceu. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 244-244, 2005.

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Forskolin-induced vasorelaxation involves Na+/Ca2+ exchanger in mouse aorta

Eiji Karashima1), Junji Nishimura1), Takahiro Iwamoto2), Katsuya Hirano1), Hideo Kanaide1)
1)Div. Mol. Cardiol., Res Inst Angiocardiol., Grad. Sch. Med. Sci., Kyushu Univ., 2)Dept. Pharmacol., Fukuoka Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 244-244, 2005.

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Effects of an AMP-activated protein kinase (AMPK) activator on glucose uptake and lipid utilization in normal and Zucker-fatty rat hindlimb perfusion

Hiroyasu Hirose, Yukina Tokushima, Takashi Shirakura, Jun Suzuki
Banyu Pharmaceutical Co., Ltd., Tsukuba Res. Inst.
Journal of Pharmacological Sciences 97 (suppl.2) 244-244, 2005.

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PAR-1 pepducins (intracellular agonist and antagonist): Distinct activity in multiple cells/tissues

Tsuyoshi Ishiki1), Satoko Kubo1), Ichiko Doe1), Fumiko Sekiguchi1), Mami Nagataki1), Hiroyuki Nishikawa2), Makoto Tanaka2), Atsufumi Kawabata1)
1)Div. Physiol. Pathophysiol., Sch. Pharmaceut. Sci., Kinki Univ., 2)Fuso Pharmaceut. Ind. Ltd., Osaka, Japan
Journal of Pharmacological Sciences 97 (suppl.2) 244-244, 2005.

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A novel peptide-mimetic PAR-2 antagonist K-14585: inhibition of PAR-2-agonist-mediated relaxation on isolated rat artery and increased vascular permeability in guinea pigs

Shoichi Kondo1), Satoko Kubo2), Toshiaki Takizawa1), Mototsugu Kabeya1), Hiroyuki Ishiwata1), Jiro Matsumoto1), Yukio Hattori1), Toru Kanke1), Atsufumi Kawabata2)
1)Tokyo New Drug Res. Lab. 2, Pharmaceut. Div., Kowa Co. Ltd., 2)Div. Physiol. Pathophysiol., Sch. Pharmaceut. Sci., Kinki Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 245-245, 2005.

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Hyper-contraction by the arachidonic acid of vascular smooth muscle

Takeshi Katayama, Mizuki Hino, Shinji Yoshiyama, Akio Nakamura, Kazuhiro Kohama
Dept. of Mol. and Cell. Pharmacol., Gunma Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 245-245, 2005.

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Involvement of Rho/Rho-kinase pathway in endothelin-induced contraction in rat aorta and trachea

Takaki Yamamura1), Chiiko Takahashi1), Miho Akasaka1), Asami Gotoh1), Shunsuke Ichinohe1), Kyusa Abe2), Michiyo Endoh2)
1)Dept. Childhood Education, Morioka Univ., 2)Dept. Food and Nutrition, Morioka Junior Coll.
Journal of Pharmacological Sciences 97 (suppl.2) 245-245, 2005.

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Local Ca2+ control and Ca2+ wave during E-C coupling in mouse urinary bladder smooth muscle cells

Kozo Morimura, Susumu Ohya, Katsuhiko Muraki, Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch. of Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 245-245, 2005.

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Changes in the mechanism of smooth muscle contraction in aged rat urinary bladders

Tomomi Aita1), Kozue Aita1), Akiko Yamada1), Kinuko Konno1), Akira Ishihata2), Yumi Katano1)
1)Div. Theoretic. Nurs. & Pathophysiol., Yamagata Univ. Sch. Med., 2)Dept. Physiol., Yamagata Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 246-246, 2005.

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Capsaicin-induced, vanilloid receptor-independent relaxation in the guinea-pig ileum

Seigo Fujimoto1), Mayumi Mori1), Hiromi Tsushima1), Mitoshi Kunimatsu2)
1)Dept. Cell Mol. Pharmacol., Nagoya City Univ., Grad. Sch. Med. Sci., 2)Dept. Home Economics., Nagoya Women's Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 246-246, 2005.

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In vitro development of intestine-like tissue demonstrating rhythmic motility from embryonic mouse intestinal cells: role of bFGF

Yuko Ito, Kazuhiko Oishi, Masaatsu Uchida
Dept. Pharmacol., Meiji Pharmaceutical Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 246-246, 2005.

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Electrophysiological properties of isoforms of T-type Ca+2, channel Cav3.2 expressed in human uterus

Tsuyako Ohkubo1), Yoshihiko Inoue2), Tatsuhiko Kawarabayashi2), Kenji Kitamura1)
1)Dept. Physiol. Sci. & Mol. Biol., Fukuoka Dent. Coll., 2)Dept. Obstet. & Gynecol., Fukuoka Uni. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 246-246, 2005.

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Involvement of the endogenous prostaglandins in regulation of spontaneous contraction in non-pregnant porcine uterus

Jinshan Cao, Takio Kitazawa, Tetsuro Taneike
Dept. Pharmacol., Sch. of Vet. Med., Rakuno Gakuen Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 247-247, 2005.

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Effects of Th1/2 cytokines on the contractility of airway smooth muscle cells

Yoshinori Ohta, Masahiro Oike, Yushi Ito
Dept. Pharmacol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 247-247, 2005.

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β3-adrenoceptor mediating airway smooth muscle relaxation

Miwa Kondo1), Hitomi Matsuda1), Kenichi Kumasaka1)2), Hiroko Moroe1), Hideo Honda3)
1)2nd Dept. Physlol., Showa Univ. Sch. Med., 2)Kanagawa Pref. Inst. Pub. Health, 3)Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 247-247, 2005.

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Pharmacological evidence that noradrenaline(NA)-elicited relaxation of tracheal smooth muscle is mediated throughβ-adrenoceptor(β-AR)subtypes distinct from established β1-3

Aya Minemura, Fumiko Yamaki, Takahiro Horinouchi, Yoshio Tanaka, Katsuo Koike
Dept. Chem. Pharmacol, Toho Univ. Sch. Pharmaceu. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 247-247, 2005.

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SP600125-sensitive pathway modulates airway smooth muscle contraction in guinea pigs

Kiyoshige Saito1), Yasuo Kizawa1), Katsuo Koike2), Tadashi Kusama1)
1)Dept. Physiol. & Anat., Nihon Univ. Coll. Pharm., 2)Dept. Chem. Pharmacol., Toho Univ. Sch. Pharmaceut. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 248-248, 2005.

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Pharmacological studies on the respiratory tract (Rept. 268): Airway inflammation and bronchial smooth muscle hyperresponsiveness induced by chronic exposure to cigarette smoke

Masahiko Murata1), Hiroko Ushikubo1), Yoshihiko Chiba1), Hiroyasu Sakai1), Junzo Kamei2), Miwa Misawa1)
1)Dept. of Pharmacol., Sch. of Pharm., Hoshi Univ., 2)Dept. of Pathophysiology and Therapeutics, Sch. of Pharm., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 248-248, 2005.

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Vanilloid receptor subtype 1 expressed in rat skeletal muscle

Hong Xin1), Akio Nakamura1), Maki Yamaguchi2), Shigeru Takemori2), Hideki Tanaka1), Kazuhiro Kohama1)
1)Dept. Mol. and cellular Pharmacol., Gunma Univ Grad.. Sch. Med., 2)Dept. Physiol I., Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 248-248, 2005.

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Intracellular localization of Dysferlin in skeletal muscle

Beryl N. Ampong1), Michihiro Imamura1), Teruhiko Matsumiya1), Shin'ichi Takeda2), Mikiharu Yoshida1)
1)Dept. Molc. Ther., Natl. Inst. Neurosci, 2)Dept. Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 248-248, 2005.

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Expression and characterization of full length myosin II

Xiaohua Feng1), Ying Zhang1), Hozumi Kawamiti1), Akio Nakamura1), Koichi Samizo1), Mizuki Hino1), Laszlo Farkas2), Laszlo Nyitray2), Kazuhiro Kohama1)
1)Dept. Mot. Cell. Pharmacol., Gunma Univ. Grad. Sch. Med., 2)Dept. Biochem., Eotvos Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 249-249, 2005.

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＆-Sarcoglycan can replace γ-sarcoglycan in the sarcoglycan complex formation

Kazuo Shiga1)3), Hiroki Yoshioka2), Teruhiko Matsumiya3), Shin'ichi Takeda1), Michihiro Imamura1)
1)National Inst. of NeuroSci., NCNP, 2)Sch. of Human Sci., Waseda Univ., 3)Dept. of Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 249-249, 2005.

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Metabolic acidosis enhances the fibrate-induced myopathy

Sachiko Juman, Keiko Nadamoto, Takeshi Akiyoshi, Yuka Kitada, Namie Nejime, Kazumasa Shinozuka, Toshikatsu Nakabayashi, Kenji Matsuyama, Sumio Matsuno
First Dept. of Biochem., Sch. Pharm. Sci., Mukogawa Women's Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 249-249, 2005.

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Gene expression analysis of skeletal muscle from caveolin-3 knockout mice

Yasuko Hagiwara1), Toshikuni Sasaoka2), Michihiro Imamura1), Masako Fujita1), Satoru Noguchi1)
1)Natl. Inst. Neurosci., NCNP, 2)Natl. Inst. Basic Biol.
Journal of Pharmacological Sciences 97 (suppl.2) 249-249, 2005.

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Herb derived substances, lignans are protecive against reactive oxygen species in murine skeletal muscle C2C1 2 cells

Ayumu Yoshikawa, Masashi Asai, Mitsue Tetsuka, Yumiko Saito, Kei Maruyama
Dept. Pharmacol., Saitama Med. Sch.
Journal of Pharmacological Sciences 97 (suppl.2) 250-250, 2005.

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A possible role of adrenomedullin during pregnancy in the rat

Kazuhiko Shibata1), Yasuo Makino2), Ikuko Makino2), Yoshihisa Kitamura1), Kojiro Futagami1), Yutaka Gomita1)
1)Dept. of Hosp. Pharm., Okayama Med. Sch., 2)Dept. of Obstetrics and Gynecology, Tokyo Women's Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 250-250, 2005.

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Loss of body weight in mice lacking of taurine transporter

Takashi Ito1), Yasushi Fujio1), Satoko Muraoka1), Tsuyoshi Fukuda1), Takahisa Matsuda1), Yoriko Uozumi1), Yasushi Kimura1), Kei Ueki2), Kunio Momiyama2), Kyoko Takahashi1), Junichi Azuma1)
1)Dept. Clin. Evaluat. of Med. Therapeut. Pharm. Sch., Osaka Univ., 2)Japan Clinical Laboratories, Inc
Journal of Pharmacological Sciences 97 (suppl.2) 250-250, 2005.

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Preparation and application of the mice model for studying urinary disturbances after cerebral infarction

Gen Yamamoto, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Environ. & Molec. Health Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 250-250, 2005.

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Prostaglandin receptors EP2, EP3, and IP mediate exudate formation in carrageenin-induced mouse pleurisy

Koh-ichi Yuhki1), Akinori Ueno2), Hiroaki Naraba3), Fumiaki Kojima), Fumitaka Ushikubi1), Shuh Narumiya5), Sachiko Oh-ishi6)
1)Dept. Pharmacol., Asahikawa Med. coll., 2)Jikei Univ., DDS Inst., 3)Natl. Cardiovasc. Ctr. Res. Inst., 4)Inst. Med. Sci., St. Malianna Univ., Sch. Med., 5)Dept. Pharmacol., Kyoto Univ., Fac. Med., 6)Basic Res. Div., Kitasato Inst.
Journal of Pharmacological Sciences 97 (suppl.2) 251-251, 2005.

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Influence of caffeine on the mRNA expression of type III iodothyronine deiodinase and thyroid hormone receptor in BeWo cell culture and rat placenta

Shigeno Saito1)2), Susumu Hamajima1)2), Yoshimitu Abiko1)2)
1)Dept. Biochem., Nihon Univ. Sch. Dent., 2)Res. Inst., Oral Sci., Nihon Univ. Sch. Dent.
Journal of Pharmacological Sciences 97 (suppl.2) 251-251, 2005.

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Influence of hypothermia on the pharmacokinetics and pharmacodynamics of propofol during cardiopulmonary bypass

Yoshiro Okano1), Shiro Ishida1), Michihisa Kato2), Kazunori Yamakawa3), Yasuo Oyama4)
1)Dept. Pharmac. Care & Clin. Pharm., Fac. Pharmac. Sci., Tokushima Bunri Univ., 2)Divi. Anethesiol., Tokushima Red-Cross Hosp., 3)Divi. Pharm., Tokushima Red-Cross Hosp., 4)Lab. Cell Signaling, Fac. Integrated Arts & Sci., Tokushima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 251-251, 2005.

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Effects of low concentration of tetrabromobisphenole A on cultured rat embryos

Masaharu Akita1), Mari Kato1), Atsushi Yokoyama2), Hitoshi Kontani3)
1)Kamakura Women's Univ., 2)Kanagawa Life Sci. Res. Lab., 3)Hokuriku Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 251-251, 2005.

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Effects of continuous ingestion of herbal teas on midazolam pharmacokinetics in rats

Yuki Nishimura, Norimitsu Kurata, Mariko Iwase, Hajime Yasuhara
Dept. Pharmacol., Sch. Med., Showa Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 252-252, 2005.

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Response to endogenous and exogenous vasopressin V2 receptor stimulation is intact in mice lacking V1a or V1b receptors

Toyoki Mori1), Shizuo Kinoshita1), Hiroyuki Fujiki1), Shigeki Nakamura1), Toshiki Miyazaki1), Shuji Itoh1), Akito Tsunoue2), Gozoh Tsujimoto3)
1)Res. Inst. Pharmacol. and Ther. Develop., Otsuka Pharmaceutical Co., Ltd., 2)Dept. Mol. Cell Pharmacol., Nat. Res. Inst. for Child Health and Develop, 3)Dept Genomic Drug Discov. Sci., Grad. Sch. of Pharmaceu Sci., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 252-252, 2005.

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Endothelins participates the generation of pre-micturition contractions in rats with bladder outlet obstruction

Hiroko Okutsu, Hironori Yuyama, Masashi Ukai, Yukiko Noguchi, Akiyoshi Someya, Mai Watanabe, Taiji Yoshino, Akiyoshi Ohtake, Masanori Suzuki, Shuichi Sato, Masao Sasamata
Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 252-252, 2005.

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The effects of ET-1 and YM598, a novel selective endothelin ETA receptor antagonist, on the lower urinary tract

Hironori Yuyama, Akira Fujimori, Akiko Koakutsu, Masanao Sanagi, Masashi Ukai, Akiyoshi Ohtake, Shuichi Sato, Katsumi Sudoh, Masao Sasamata
Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 252-252, 2005.

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The potency of a selective ETA receptor antagonist YM598 as a drug for renal diseases

Mari Nakata, Hironori Yuyama, Akiko Koakutsu, Masanao Sanagi, Atsuo Tahara, Akira Fujimori, Shuichi Sato, Masao Sasamata
Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 253-253, 2005.

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Effect of tamsulosin on involuntary bladder contractions in conscious rats with bladder outlet obstruction

Akiyoshi Ohtake, Masashi Ukai, Hironori Yuyama, Noriko Fujiyasu, Yukiko Noguchi, Shuichi Sato, Masao Sasamata
Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 253-253, 2005.

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Effects of solifenacin succinate on voiding function in the experimental cerebral infarcted rats

Masashi Ukai, Masanori Suzuki, Akiyoshi Ohtake, Taiji Yoshino, Hironori Yuyama, Aska Hayashi, Hiroko Okutsu, Yukiko Noguchi, Shuichi Sato, Masao Sasamata
Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 253-253, 2005.

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Tissue-selectivity of solifenacin succinate for urinary bladder over salivary gland in rats

Yukiko Noguchi, Masashi Ukai, Akiyoshi Ohtake, Ken Ikeda, Shuichi Sato, Masao Sasamata
Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 253-253, 2005.

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Bladder selectivity of anticholinergic drugs to treat overactive bladder by in vivo measurement of muscarinic receptors (mAChR) in mouse tissues

Shuji Maruyama, Kayoko Shimada, Kenichi Sakakura, Tomomi Oki, Shizuo Yamada
Dept. of Biopharm., Sch. of Pharm. Sci. and COE21, Univ. of Shizuoka
Journal of Pharmacological Sciences 97 (suppl.2) 254-254, 2005.

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Residual urinary concentrating ability in a rat models for chronic renal failure: Response to water restriction or subcutaneous dDAVP infusion

Katsuya Suzuki1), Mitsunobu Matsubara2), Teruyuki Yanagisawa1)
1)Mol. Pharmacol., Tohoku Univ. Sch. Med., Sendai, 2)Div. of Mol. Med., Tohoku Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 254-254, 2005.

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Measurements of bladder function by conscious and unrestrained cystometry in the dysuria model rat

Nahoko Maeda, Ryoji Mizumachi, Mayu Sameshima, Takashi Tashiro, Hiroshi Atai, Katsuhide Nishi
Panapharm Laboratories Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 254-254, 2005.

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Effect of methoctramine (Met) on urinary bladder contraction induced by the electrical stimulation (ES) of the pelvic nerve(PLN) in anesthetized rat

Naoki Aizawa, Hitoshi Kontani
Dept. Pharmacol., Fac. Pharm. Sci., Hokuriku Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 254-254, 2005.

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The effects of flavoxate hydrochloride on the voltage-dependent L-type Ca2+ currents in the human urinary bladder

Toshihisa Tomoda1), Manami Aishima1), Noriyoshi Teramoto1), Naruaki Takano2), Toshiaki Nakano3), Narihito Seki2), Yoshikazu Yonemitsu3), Katsuo Sueishi3), Seiji Naito2), Yushi Ito1)
1)Dept. Pharmacol., Med. Sch., Kyushu Univ., 2)Dept. Urol., Med. Sch., Kyushu Univ., 3)Dept. Pathol., Med. Sch., Kyushu Univ
Journal of Pharmacological Sciences 97 (suppl.2) 255-255, 2005.

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The channel pore protein of KATP channels in the human detrusor is mainly composed of Kir6.2

Manami Aishima1), Takakazu Yunoki2), Noriyoshi Teramoto1), Toshiaki Nakano3), Yoshikazu Yonemitsu3), Katsuo Sueishi3), Narihito Seki2), Yushi Ito1), Seiji Naito2)
1)Dept. Pharmacol., Med. Sch., Kyushu Univ., 2)Dept. Urol., Med. Sch., Kyushu Univ., 3)Dept. Pathol., Med. Sch., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 255-255, 2005.

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A role of nitric oxide synthase in the gender difference of ischemic acute renal failure

Mitsunori Nishikawa, Masanori Takaoka, Masateru Taira, Aiko Satake, Keisuke Kitano, Yujiro Shibata, Yasuo Matsumura
Dept. Phamacol., Univ. Pharmaceut. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 255-255, 2005.

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Preventive effect of moxonidine on ischemic acute renal failure in rats

Hidenobu Tsutsui, Takahiro Sugiura, Masanori Takaoka, Yasuo Matsumura
Dept. Phrmacol., Osaka Univ. Pharmaceut. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 255-255, 2005.

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Mechanisms underlying chronic glomerular injury. Involvement of proteasome in disposal of aggregated protein in glomeruli

Tadashi Nagamatsu, Kenji Katsuragawa, Misaki Mano, Yasushi Hirasawa
Dept. Pharmacol., Meijo Univ. Sch. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 256-256, 2005.

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Involvement of hyperglycemia with deposition of aggregated bovine serum albumin and processing in renal glomeruli

Yasushi Hirasawa1)2), Yukari Matsui2), Shoko Ohtsu2), Takahiko Nagase2), Miwa Tomioka2), Tohru Toyoshi2), Yoshio Suzuki1), Tadashi Nagamatsu1)
1)Dept. Pharmacol., Faculty of Pharm., Meijo Univ., 2)Nihon BioRes. Inc.
Journal of Pharmacological Sciences 97 (suppl.2) 256-256, 2005.

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Relationship between plasma mycophenolic acid and its glucuronide concentrations, and adverse effects in renal transplant patients

Takafumi Naito1), Shinya Uchida2), Kazuko Shinno1), Yasunori Miyamoto1), Tatsuya Takayama4), Kazuo Suzuki4), Seichiro Ozono4), Masahiro Nakano3), Kyoichi Ohashi2), Hisakuni Hashimoto1)
1)Div. Hosp. Pharm., Hamamatsu Univ. Sch. Med., 2)Dept. Clin. Pharm, Ther., Hamamatsu Univ. Sch. Med., 3)Dept. Clin. Pharm., Univ. Shizuoka, 4)Dept. Urol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 256-256, 2005.

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Identification and functional characterization of a novel organic anion transporter OAT9

Habib Hasannejad, Taku Hirata, Ellappan Babu, Hirokazu Yokoyama, Naohiko Anzai, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 256-256, 2005.

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Identification of the intracellular binding protein with proton-coupled oligopeptide transporter PEPT2 using yeast two-hybrid assay

Takeshi Sakata, Naohiko Anzai, Rie Noshiro, Hiroki Miyazaki, Yoshikatsu Kanai, Hitoshi Endou
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 257-257, 2005.

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Gene expression profile in experimental mesangial proliferative glomerulonephritis

Yasukatsu Izumi, Masayuki Shiota, Ryotaro Wake, Kaoru Yoshida, Hiroshi Iwao
Dept. Pharmacol., Osaka City Univ. Med. Sch.
Journal of Pharmacological Sciences 97 (suppl.2) 257-257, 2005.

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Nuclear speckle localization of AGN-1 gene that is up-regulated in glomerulonephritis

Ryoji Kojima1), Hiroyuki Manshio2), Mikio Ito2)
1)Lab. Pharmacol., Fac. Pharm., Meijo Univ., 2)Lab. Anal. Pharmacol., Fac. Pharm., Meijo Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 257-257, 2005.

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Expression and role of multi-drug resistant protein 1 (mdr1) in rat prostate

Masami Tanaka1)2), Minoru Watanabe2), Sachiko Nakaya2), Toshio Kumai2), Shinichi Kobayashi2)
1)Inst. Experimental Animals, St. Marianna Univ. Grad. Sch. Med., 2)Dept. Pharmacol., St. Marianna Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 257-257, 2005.

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Selective ETA receptor antagonist YM598 inhibits ET-1 -induced cell signaling and cell growth in hormone refractory human prostate cancer cell line, PPC-1

Mai Watanabe1), Hironori Yuyama1), Akira Fujimori1), Mikiko Mori2), Shuichi Sato1), Katsumi Sudoh1), Masao Sasamata1)
1)Pharmacol. Lab., Yamanouchi Pharm. Co., Ltd., 2)Clinical Development Dept., Yamanouchi Pharm. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 258-258, 2005.

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Overexpression of LAT1 and 4F2hc in clear cell RCCs and clinicopathological relevance LAT1

Ahmed Nesar, Yoshikatsu Kanai, Hitoshi Endou
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 258-258, 2005.

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Hepatocyte growth factor prevents NMDA-induced cell death through an ERK-dependent pathway in cultured hippocampal neurons

Naoko Ishihara1), Norio Takagi1), Keiko Takagi1), Kunio Matsumoto2), Toshikazu Nakamura2), Satoshi Takeo1)
1)Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm. Life Sci., 2)Div. Mol. Regenerative Med., Osaka Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 258-258, 2005.

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NMDA-receptor prestimulation in the absence of extracellular calcium potentiates calcium influx-dependent neuronal cell death

Kohtaro Kato
Dept. Cell. Physiol. Chem., Tokyo Med. and Dent. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 258-258, 2005.

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Modulation of NR1/NR2B-subtype NMDA receptor channels by SAP-102

Yasue Yamada, Makoto Inui
Dept. Pharmacol. Yama uchi Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 259-259, 2005.

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Effects of cyanide on synaptic transmission in rat hippocampal slices

Kazunaga Takahashi, Takashi Iwai, Jun-Ichiro Oka
Lab. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 259-259, 2005.

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The protein kinase CK2 modulates the threshold of NMDA receptor-dependent synaptic plasticity

Rie Kimura, Norio Matsuki
Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 97 (suppl.2) 259-259, 2005.

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Intra-arterial injection of microglia protects electrophysiological and morphological properties of hippcampal CA1 neurons against global ischemia

Hiroshi Nakanishi1), Yoshiro Tomimatsu1), Yoshinori Hayashi1), Jun Yamada1), Hiromi Suzuki2), Makoto Sawada2)
1)Lab. Oral Aging Sci., Fac. Dent., Kyushu Univ., 2)Inst. Comp. Med. Sci. Fujita Health Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 259-259, 2005.

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Neuropharmacological characterization of HON0001, an orally active NMDA receptor NR2B subunit antagonist

Sayoko Suetake-Koga1), Shiho Hirota-Okuno1), Toshiharu Shimazaki1), Noriko Hino1), Mariko Nishiguchi1), Yoshinori Sekiguchi1), Shigeyuki Chaki1), Toyohiko Kikuchi2), Yoshimitsu Matsui2), Tsutomu Suzuki2), Minoru Narita2), Toshio Honda2)
1)Taisho Pharmaceutical Co., Ltd., 2)Faculty of Pharmaceutical Sci., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 260-260, 2005.

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Involvement of brain arginine increase in glufosinate ammonium-induced delayed convulsion

Nobuko Matsumura, Mami Okanaga, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 260-260, 2005.

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MK-801 upregulates the gene expression of D-serine-related enzymes in rat brain

Masanobu Yoshikawa1), Tetsuo Oka1), Tomomi Kobayashi1), Mitsuru Kawaguchi2), Atsushi Hashimoto1)
1)Dept. Pharmacol., Tokai Univ. Sch. Med., 2)Dept. Pharmacol. Tokyo Dental Coll.
Journal of Pharmacological Sciences 97 (suppl.2) 260-260, 2005.

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Roles of neuropeptides and peptidases in MK-801-treated schizophrenic model rat brain; effect of neuroleptics

Takeshi Kato1), Mohammad Arif1), Md. Mahiuddin Ahmed1), Yukiko Kumabe1), Hajime Hoshino1), Toshiyuki Chikuma2)
1)Labos. Natural Info. Sci./ Mol. Recog., Grad. Sch. Integr. Sci., Yokohama City Univ., 2)Dept. Hygienic Chem., Showa Pharmaceut. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 260-260, 2005.

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Chronic treatment with dibutyryl cAMP promotes L-glutamate-stimulated lactate release from cultured rat cortical astrocytes

Takumi Fujita1), Kazuho Abe2), Miwa Misawa1)
1)Dept. Pharmacol., Sch. Pharm., Hoshi Univ., 2)Lab. Pharmacol., Fac. Pharm., Musashino Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 261-261, 2005.

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Mechanism of glutamate-induced neuronal cell death - Degradation of p27 by calpain and cell cycle reentry -

Hiroki Akashiba, Maki Yamada, Norio Matsuki, Nobuyoshi Nishiyama
Lab. of Chemical Pharmacol., Grad. Sch. of Pharmaceutical Sci., The Univ. of Tokyo
Journal of Pharmacological Sciences 97 (suppl.2) 261-261, 2005.

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Effects of LPS on glutamine transporter expressed in cultured cortical astrocytes

Masato Ogura, Katsura Takano, Noritaka Nakamichi, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech., Kanazawa
Journal of Pharmacological Sciences 97 (suppl.2) 261-261, 2005.

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Effect of AM PA receptor antagonist YM872 on cerebral hematoma size and neurological recovery in the intracerebral hemorrhage rat model

Kazuhiro Terai1), Masanori Suzuki2), Masao Sasamata2), Shin-ichi Yatsugi1), Tokio Yamaguchi3), Keiji Miyata4)
1)Cardiovasc. Dis. Res., Inst. Pharmacol., Yamanouchi Pharmaceut. Co., 2)Appl. Pharmacol., Inst. Pharmacol., Yamanouchi Pharmaceut. Co., 3)Res. Coord. Dept., Yamanouchi Pharmaceut. Co., 4)Inst. Pharmacol., Yamanouchi Pharmaceut. Co.
Journal of Pharmacological Sciences 97 (suppl.2) 261-261, 2005.

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Selective expression of heteromeric AMPA receptors

Takeshi Suzuki1)2), James Brorson2)
1)Dept. Basic Biol. Sci., Kyoritsu Univ. Pharm., 2)Dept. Neurol., Univ. Chicago
Journal of Pharmacological Sciences 97 (suppl.2) 262-262, 2005.

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Structural analysis of ATP-binding site of P2X receptor

Iyuki Namekata1), Mie Ito1), Naoko Iida-Tanaka2), Masaaki Kurihara3), Yukiko Sato3), Yoko Yamakoshi3)5), Hikaru Tanaka1), Koki Shigenobu1), Ken-ichi Nakazawa4)
1)Dept. Pharmacol., Toho Univ. Sch. Pharmaceut. Sci., 2)Dept. Food Sci., Otsuma Woman's Univ., 3)Div. Org. Chem., Natl. Inst. Health Sci., 4)Div. Pharmacol., Natl. Inst. Health Sci., 5)Polymer Inst., UCSB
Journal of Pharmacological Sciences 97 (suppl.2) 262-262, 2005.

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P2Y1, receptor-mediated Ca2+, propagation in the hippocampus

Schuichi Koizumi1), Kayoko Fujishita2), Kazuhide Inoue2)3)
1)Div. Pharmacol., Natl. Inst. Hlth. Sci., 2)Div. Biosignal., Natl. Inst. Hlth. Sci., 3)Grad Sch. Pharmaceut. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 262-262, 2005.

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Pericyte-to-astrocyte communication via extracellular ATP

Kayoko Fujshita1), Schuichi Koizumi2), Kazuhide Inoue1)3)
1)Div. Biosignaling, Natl. Inst. Hlth. Sci., 2)Div. Pharmacol., Natl. Inst. Hlth. Sci., 3)Grad. Sch. Pharmaceutical Sci., Kyusyu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 262-262, 2005.

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Retinoic acid upregulates P2X4 receptor expression in microglia

Hidetoshi Tozaki1)2), Yukari Shigemoto-Mogami1), Schuichi Koizumi3), Makoto Tsuda1), Kazuhide Inoue1)2)
1)Div. Biosignal., Natl Inst., Hlth Sci., 2)Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 3)Div. Pharmacol., Natl Inst., Hlth Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 263-263, 2005.

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Role of fibronectin in the expression of P2X4 receptors in microglia and in pain signaling

Emiko Kunifusa1)2), Makoto Tsuda1), Kaoru Tada3), Schuichi Koizumi3), Kazuhide Inoue1)2)
1)Div. Biosignaling., Natl. Inst. Hlth. Sci., 2)Grad. Sch. Pharmaceutical Sci., Kyushu Univ., 3)Div. Pharmacol., Natl. Inst. Hlth. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 263-263, 2005.

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The physiological function of P2Y6 receptor in rat microglial cells

Yukari Shigemoto-Mogami1), Schuichi Koizumi2), Kaoru Tada2), Makoto Tsuda1), Kazuhide Inoue1)3)
1)Div. Biosignal., Natl. Inst. Hlth. Sci., 2)Div. Pharmacol., Natl. Inst. Hlth. Sci., 3)Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 263-263, 2005.

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The physiological function of P2Y6 receptor in rat microglial cells

Kaoru Nasu-Tada1), Schuichi Koizumi1), Kazuhide Inoue2)3)
1)Div. Pharmacol., Natl. Inst. Hlth. Sci., 2)Div. Biosignal., Natl. Inst. Hlth. Sci., 3)Grad.Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 263-263, 2005.

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PLC-independent cation permeability activated by P2Y1, receptor in inhibitory interneurons in the rat hippocampus

Masahito Kawamura1), Fusao Kato2)
1)Dept. Pharmacol. I, Jikei Univ. Sch. Med., 2)Lab. Neurophysiol., Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 264-264, 2005.

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Nitric oxide downregulates lipopolysaccharide-induced expression of microsomal prostaglandin E2 synthase-1 in rat microglia

Ai ito
Dept. Pharmacol. Sch., Pharmc. Sci., Kitasato Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 264-264, 2005.

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Visualization of microglia in Iba1 -EGFP transgenic mice

Takae Okuno-Hirasawa1), Keiko Ohsawa1), Yoshinori Imai2), Chihiro Akazawa1), Shigeo Uchino1), Shinichi Kohsaka1)
1)Dept. Neurochem. NCNP, 2)Dept. Molecullar and Cell. Biology, Ehime Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 264-264, 2005.

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Activation of rat nicotinic cholinergic system in the prelimbic cortex attenuates reinstatement of methamphetamine-seeking behavior

Takato Hiranita, Michihiko Miyamoto, Katsuya Sakimura, Kusnandar Anggadiredja, Chie Fujisaki, Tsuneyuki Yamamoto
Dept. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 264-264, 2005.

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Changes of nicotine and cotinine levels after cigarette smoke in the brain of spontaneously hypertenshive rats

Kaoru Kubo1), Takeshi Tanaka2), Toshikatsu Nakashima3)
1)Lab. Animal Res. Ctr., 2)Nara Prefectural Inst. for Hygiene and Environment, 3)Faculty of Health Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 265-265, 2005.

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Effects of nicotine on stress stimulation: in vitro experiments

Akiko S Shingo, Shozo Kito
Lab. Neurosci., Hyogo Univ. Sch. of Health Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 265-265, 2005.

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Effects of nicotine on neural development and plasticity in the hippocampus

Shozo Kito, Akiko S. Shingo
Lab. Neurosci., Hyogo Univ. Sch. of Health Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 265-265, 2005.

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Alkaloids indolizidine 235B' and (-)-pictamine block neuronal α4β2 nicotinic acetylcholine receptors

Yueren You1), Hiroshi Tsuneki1), Naoki Toyooka2), Toshiyasu Sasaoka1), Hideo Nemoto2), John A. Dani3), Ikuko Kimura1)
1)Dept. Clin. Pharmacol., Toyama Med. and Pharmaceutical Univ., 2)Faculty Pharm. Sci., Toyama Med. and Pharmaceutical Univ., 3)Dept. Neurosci., Baylor Coll. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 265-265, 2005.

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PKC inhibits the deactivation of nicotinic acetylcholine receptor α4β2 subtype

Hiroaki Matsubayashi, Toh-Yoon Wong, Taku Amano, Takahiro Seki, Norio Sakai
Dept. Mol. and Pharmacol. Neurosci., Grad. Sch. of Biomedical Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 266-266, 2005.

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Role of acetylcholine and α-adrenergic receptors in the nucleus accumbens shell in rat turning behaviour

Shoko Moribe1), Michiko Sato1), Hiroko Ikeda1), Kazuya Hasegawa2), Noriaki Koshikawa1)
1)Dept. Pharmacol., Nihon Univ. Sch. Dent., 2)Dept. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. of Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 266-266, 2005.

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Effects of allopregnanolone microinjected into the commissural subnucleus of the nucleus tractus solitarius on the chemoreceptor reflex in rat

Masahiko Suzuki1), Shin-ichi Nakamura2), Kei Maruyama1)
1)Dept. Pharmacol., Saitama Med. Sch., 2)Dept. Anesth., Saitama Med. Sch.
Journal of Pharmacological Sciences 97 (suppl.2) 266-266, 2005.

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Effects of codeine on EPSCs in second-order neurons of the nucleus tractus solitarius in guinea pig brainstem slices

Yoshiaki Ohi, Akira Haji, Hiromi Yamazaki, Ryuji Takeda
Dept. Pharmacol. Fac. Med., Toyama Med. and Pharmaceut. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 266-266, 2005.

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Timing of synaphin/complexin binding to SNARE complex was probed by caged binding-site peptide

Hiroshi Tokumaru1)2), George Augustine2), Norio Shimamoto1)
1)Dept. Pharmaceu. Tech. Tokushima Bunri Univ., 2)Dept. Neurobiol., Duke Univ. Med. Ctr.
Journal of Pharmacological Sciences 97 (suppl.2) 267-267, 2005.

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Presynaptic TrkB receptors regulate short-term plasticity at the hippocampal CA3-CA1 synapses

Eiko Kato1), Noriko Kumazawa2), Tomonori Takeuchi1), Toshiya Manabe2), Haruka Matsushiro1), Hisashi Mori1), Masahiro Fukaya3), Masahiko Watanabe3), Kaori Akashi4), Kenji Sakimura4), Masayoshi Mishina1)
1)Dept. of Mol. Neurobiol. & Pharmacol., Grad. Sch. of Med., Univ. of Tokyo and SORST/JST, 2)Div. of Neuronal Network, Dept. of Basic Med. Sci., Inst. of Med. Sci., Univ. of Tokyo, 3)Dept. of Anatomy, Grad. Sch. of Med., Univ. of Hokkaido, 4)Dept. of Cell. Neurobiol., Brain Res. Inst., Niigata Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 267-267, 2005.

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Disinhibition of hippocampal CA3 pyramidal cells due to proteolytic degradation of glutamate decarboxylase in cathepsin D-deficient mice

Tokiko Shimizu1)2), Yoshinori Hayashi1), Jun Yamada1), Jian Zhang1), Kiyoharu Ukai3), Kazunori Mine2), Hiroshi Nakanishi1)
1)Lab. Oral Aging Sci., Fac. Dent. Sci., Kyushu Univ., 2)Dept. Medico, Grad. Sch. Pharmac. Sci., Kyushu Univ., 3)Cent. Res. Inst., Kaken Pharmac. Co. Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 267-267, 2005.

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Role of GABAA receptors in the substantia nigra pars reticulata in rat turning behaviour

Hiroko Ikeda1), Shoko Moribe1), Michiko Sato1), Kazuya Hasegawa2), Noriaki Koshikawa1)
1)Dept. Pharmacol., Nihon Univ. Sch. Dent., Tokyo, 2)Dept. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. of Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 267-267, 2005.

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Effects of intrathecal baclofen on anemic decerebrate ridigity in rats

Miho Kuroiwa, Yutaka Kitano, Kiyoshi Takasuna
New Product Res. Laboratories II, Daiichi Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 268-268, 2005.

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Effect of diabetes on the zolpidem-induced sedation in mice

Shigeo Miyata, Shoko Hirano, Junzo Kamei
Dept. of Pathophysiol. and Therap., Sch. of Pharm. and Pharm. Sci., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 268-268, 2005.

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Zonisamide at clinically relevant concentrations inhibits evoked EPSP but not presynaptic fiber volley in rat frontal cortex

Chin-Wei Huang1), Shinya Ueno2), Motohiro Okada1), Sunao Kaneko1)
1)Dept. of Neuropsychiatry, Hirosaki Univ. Sch. of Med., 2)Rehabilitation Med., Inst. of Brain Sci., Hirosaki Univ. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 268-268, 2005.

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Sub-convolusive dosage of picrotoxin is ineffective for the diazepam-induced respiratory inhibition

Shin-ichi Nakamura1)2)3), Masahiko Suzuki2), Kei Maruyama2), Hiroshi Nagasaka3)
1)Dept. Anesth., Saitama Med. Sch., 2)Dept. Phamacol., Saitama Med. Sch., 3)Dept. Anesth., Meikai Univ. Sch. Den.
Journal of Pharmacological Sciences 97 (suppl.2) 268-268, 2005.

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Constitutive secretion of BDNF leads to increase in presynaptic GAD65

Takarnitsu Ikeda, Norio Matsuki, Maki Yamada
Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 97 (suppl.2) 269-269, 2005.

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Alterations in expression of BDNF and plasma corticosterone level in the olfactory bulbecomized rats

Miwako Shobo, Masahiko Morita, Tomoya Oe, Toshiaki Aoki, Noriaki Inamura
Exploratory Res. Laboratories, Fujisawa Pharmaceutical Co. Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 269-269, 2005.

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Repeated electroconvulsive stimuli increases brain-derived neurotrophic factor in ACTH-treated rats

Bingjin Li1), Katsuya Suemaru2), Ranji Cui2), Yoshihisa Kitamura3), Yutaka Gomita3), Hiroaki Araki2)
1)Clin. Physiol. Funct. Stud. Ehime Univ. Grad. Sch. Med., Toon, 2)Div. Pharm., Ehime Univ. Hosp., Shitsukawa Toon, 3)Dep. Hosp. Pharm., Okayama Univ. Med. Sch.
Journal of Pharmacological Sciences 97 (suppl.2) 269-269, 2005.

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(-)-BPAP upregulates the expression of neurotrophins and bcl-2 in mesencephalic slice cultures

Seiko Kawakami1), Chieko Hirami1), Kazue Takahata1), Kumi Nakamura1), Seiichiro Shimazu1), Fumio Yoneda1), Hiroshi Katsuki2), Akinori Akaike2)
1)Res. Inst., Fujimoto Pharmaceutical Corp., Matsubara, 2)Dept. Pharmacol. Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 269-269, 2005.

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Effect of (-)-1-(benzofuran-2-yl)-2-propylaminopentane on the expression of neurotrophins and superoxide dismutase 1 activity in midbrain slice cultures

Kumi Nakamura1), Kazue Takahata1), Chieko Hirami1), Seiko Kawakami1), Seiichiro Shimazu1), Fumio Yoneda1), Hiroshi Katsuki2), Akinori Akaike2)
1)Res. Inst., Fujimoto Pharmaceutical Corp., Matsubara, 2)Dept. Pharmacol., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 270-270, 2005.

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Studies on drug dependence (Rept. 404): Implication of brain-derived neurotrophic factor in methamphetamine-induced discriminative stimulant effect and hyperlocomotion in mice

Taizo Kita, Minoru Narita, Kazue Aoki, Keiko Shindo, Yasuyuki Nagumo, Yoshinori Yajima, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 270-270, 2005.

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Effects of methamphetamine on neurogenesis in the adult mouse hippocampus

Takeshi Hiramoto, Yasunari Kanda, Yoshiaki Ihara, Yasuhiro Watanabe
Dept. Pharmacol., Natl. Def. Med. Coll.
Journal of Pharmacological Sciences 97 (suppl.2) 270-270, 2005.

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A possibility of Leu-lle as a novel therapeutic agent for methamphetamine-induced dependence

Minae Niwa1), Atsumi Nitta1), Yuichiro Yamada1), Kuniaki Saito2), Mitsuru Seishima2), Shen Liya3), Yukihiro Noda1), Toshitaka Nabeshima1)
1)Dept. of Neuropsychopharmacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. of Med., 2)Dept. of Informative Clinical Med., Gifu Univ. Grad. Sch. of Med., 3)Lab. of Cell. Carcinogenesis and Tumor Promotion Ctr. for Cancer Res.
Journal of Pharmacological Sciences 97 (suppl.2) 270-270, 2005.

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Behaviral sensitization regimen with low doses of methamphetamine induces neurotoxic changes in the medial prefrontal cortex in rats

Ken Kadota1)2), Tomoko Kadota2)
1)Chiba City Inst. Health and Environment, 2)Dept. Bioenviron. Med., Chiba Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 271-271, 2005.

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The analysis of electrocardiogram with telemetry system in the rat: The effect of methamphetamine and thioperamide Motohisa Kato, Tomohiro Okuda, Eiko Sakurai

Motohisa Kato, Tomohiro Okuda, Eiko Sakurai, Nobuyuki Okamura, Manabu Tashiro, Atsuo Kuramasu, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 271-271, 2005.

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Effects of inhalation anesthetics and temperature on electron spin resonance spectra of spin labels in liposome

Kunie Kimura1), Toshifumi Hiraoki2), Makiko Shibuya1), Yoshitaka Yoshimura3), Yoshiaki Deyama3), Kazuaki Fukushima1), Kuniaki Suzuki3)
1)Dept. Dent. Anesthesiolo., Grad. Sch. Dent. Med., Hokkaido Univ., 2)Dept. Applied Physics, Grad. Sch. Engineer., Hokkaido Univ., 3)Dept. Mol. Cell Pharmacolo., Grad. Sch. Dent. Med., Hokkaidou Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 271-271, 2005.

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The effects of general anesthetics on ESR spectra of spin labels located in different position in loposome

Makiko Shibuya1), Toshifumi Hiraoki2), Kunie Kimura1), Yoshitaka Yoshimura3), Yoshiaki Deyama3), Kazuaki Fukushima1), Kuniaki Suzuki3)
1)Dept. Dent. Anesthesiolo., Grad. Sch. Dent. Med., Hokkaido Univ., 2)Dept. Applied Physics, Grad. Sch. Engineer., Hokkaido Univ., 3)Dept. Mol. Cell Pharmacolo., Grad. Sch. Dent. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 271-271, 2005.

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Alterations in neuropeptide Y, CGRP and adrenomedullin receptor binding sites in animal model of schizophrenia

Osamu Nakagawasai1), Yvan Dumont3), Kei-Ichiro Watanabe2), Jean-Guy Chabot3), Lalit K. Srivastava3), Takeshi Tadano1), Remi Quirion3)
1)Dept. of Pharmacol., Tohoku Pharmaceu. Univ., 2)Dept. of Neuropsychiatry, Grad. Sch. of Med., Univ. of Tokyo, 3)Douglas Hosp. Res. Centre and Dept. of Psychiatry, McGill Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 272-272, 2005.

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A small hydrophobic dipeptide increases GDNF expression via transcription factor CREB in primary cultured neuron

Atsumi Nitta, Xiaobo Cen, Shin Ooya, Naoya Ozawa, Yukihiro Noda, Toshitaka Nabeshima
Dept. of Neuropsycho Pharmacol. and Hosp. Pharm., Nagoya Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 272-272, 2005.

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Cholecystokinin depolarizes orexin neurons via a CCKA receptor

Natsuko Tsujino, Akihiro Yamanaka, Kanako Ichiki, Yo Muraki, Takeshi Sakurai, Katsutoshi Goto
Dept. Pharmacol., Univ. of Tsukuba, Grad. Sch. of Comprehensive Human Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 272-272, 2005.

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The effects on food intake of intracerebroventricular administration of neuropeptide B under surgical stress condition in mice

Shizu Aikawa1)2), Takeshi Sakurai2)3), Akihiro Yamanaka2)3), Hirokazu Tanaka3), Katsutoshi Goto2)3)
1)Dept. Functional and Regulatory Med. Sci., Tsukuba Univ. Grad. Sch. of Comprehensive Human Sci., 2)Dept. Pharmacol. Tsukuba Univ. Ins. Basic Med. Sci., 3)ERATO, Yanagisawa Orphan Receptor Project, Japan Sci. and Technology Corporation
Journal of Pharmacological Sciences 97 (suppl.2) 272-272, 2005.

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Spinal substance P is involved in the vasopressin-induced central activation of adrenomedullary outflow in rats

Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Jyunichi Arai, Kumiko Nakamura, Yuko Hijioka, Lianyi Lu, Kunihiko Yokotani
Dept. Neuropharmacol., Grad. Sch. Med., Kochi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 273-273, 2005.

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Contribution to nitric oxide and cyclooxygenases in substance P- or NMDA-induced nociceptive response

Takaaki Komatsu1), Mika Sasaki1), Koichi Tanno2), Chikai Sakurada1), Shinobu Sakurada3), Tsukasa Sakurada1)
1)Dept. of Biochem. Daiichi Coll. of Pharmac. Sci., 2)Dept. of Pharmcol. Tohoku Pharmac. Uni., 3)Dept. of Phy and Anat Tohoku Pharmac. Uni.
Journal of Pharmacological Sciences 97 (suppl.2) 273-273, 2005.

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Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production

Yuri Ikeda-Matsuo1), Satoshi Uematsu2), Shizuo Akira2), Yasuharu Sasaki1)
1)Dept. Pharmacol. Sch. Pharmac. Sci. Kitasato Univ., 2)Dept. Host Defense, Res. Inst. Microbial Diseases
Journal of Pharmacological Sciences 97 (suppl.2) 273-273, 2005.

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Prostaglandin E2 modulates midbrain dopaminergic system via its receptor EP1

Yasuhiro Tanaka1), Tomoyuki Furuyashiki1), Toshiyuki Matsuoka1), Shiho Kitaoka1), Taku Nagai3), Kiyofumi Yamada3), Akira Mizoguchi4), Akinori Nishi5), Toshitaka Nabeshima6), Shuh Narumiya1)
1)Dept. Pharmacol., Kyoto Univ. Fac. Med., 2)Dept. Psycho., Johns Hopkins Univ., 3)Lab. Neuropsychopharm., Kanazawa Univ. Grad. Sch. Natural Sci. Tech., 4)Dept. Anat., Mie Univ. Fac. Med., 5)Dept. Physio., Kurume Univ. Sch. Med., 6)Dept. Neuropsycho. Pharmacol. and Hosp. Pharm., Nagoya Univ. Fac. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 273-273, 2005.

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Naloxone-reversible anti-nociception produced by the injection of veratridine into rat brain

Kenya Kosaka, Kazuhito Akahori, Shigeru Takahashi, Xing Lu Jin, Kayoko Iwao, Yasuhiro Niino, Yoshiharu Arai, Peng Zhang, Tomomi Kobayashi, Hiroyuki Kobayashi, Tetsuo Oka
Dept. of Pharmacol., Sch. of Med., Tokai Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 274-274, 2005.

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Effects of opioid δ-receptor antagonist against emotional changes produced by stress stimuli

Akiyoshi Saitoh, Noritaka Hirose, Junzo Kamei
Dept. Pathophysiol. Ther., Sch. Pharm Pharm. Sci., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 274-274, 2005.

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Involvement of spinal nitric oxide in big dynorphin-induced nociceptive behavior

Koichi Tan-No, Hiroaki Takahashi, Osamu Nakagawasai, Fukie Niijima, Takeshi Tadano
Dept. Pharmacol., Tohoku Pharmaceu. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 274-274, 2005.

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Central mechanisms of natriuresis in different models

Jun Kojima, Yoichi Katayama, Nobuhiro Moro, Takahiro Igarashi, Tatsuro Mori
Dept. of Neurological Surgery, Nihon Univ. Sch. of Med.
Journal of Pharmacological Sciences 97 (suppl.2) 274-274, 2005.

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Antipsychotics seen from computer chemistry

Taizo Hayano1)2), Shiroh Kishioka2), Hiroyuki Yamamoto2)
1)Div. Psychiat., Asahikai Wakaura Hosp., 2)Dept. Pharma., Wakayama Med. Univ
Journal of Pharmacological Sciences 97 (suppl.2) 275-275, 2005.

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A structure-activity relationship study for the effect of LSIGRL-NH2, a PAR-2-inactive control peptide, as a secretagogue for tear

Hiroyuki Nishikawa1), Kenzo Kawai1), Makoto Tanaka1), Hiroya Ohtani1), Shuichi Tanaka1), Chizuko Kitagawa1), Minoru Nishida1), Tomoyuki Abe1), Hiromasa Araki1), Atsufumi Kawabata2)
1)Res. Dev. Ctr., Fuso Pharmaceut. Ind. Ltd., 2)Div. Physiol. Pathophysiol., Sch. Pharmaceut. Sci., Kinki Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 275-275, 2005.

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Effects of chlorinated oxidants on the conversion of xanthine dehydrogenase (XD) to oxidase (XO) in rat liver

Satoru Sakuma, Yohko Fujimoto
Lab. Physiol. Chem. Osaka Univ. Pharmaceut. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 275-275, 2005.

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Effects of free fatty acids and fatty acyl-CoA esters on the activities of cyclooxygenase-1 and -2

Yohko Fujimoto, Satoru Sakuma
Lab. Physiol. Chem. Osaka Univ. Pharmaceut. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 275-275, 2005.

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Glycogen synthase kinase-3 : Up- and down-regulation of insulin receptor substrate-1/-2 expression

Takayuki Nemoto, Hiroki Yokoo, Shinya Satoh, Takashi Sugano, Toshihiko Yanagita, Hideyuki Kobayashi, Akihiko Wada
Dept. Pharmacol., Miyazaki Med. Coll., Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 276-276, 2005.

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Subcellular distribution of ACh-synthesizing activities in bamboo shoot (Phyllostachys bambusoides)

TomoyaYamada1), Takeshi Fujii1), Hirofumi Fujigaya1), Hidemi Misawa2), Koichiro Kawashima1)
1)Dept. of Pharmacol., Kyoritsu Coll. of Pharm., 2)Dept. of Neurol., Tokyo Metropolitan Inst. for Neurosci.
Journal of Pharmacological Sciences 97 (suppl.2) 276-276, 2005.

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Augmentation of neurotransmitter release resulted from the interaction of human alpha-1 A adrenoceptor (HuA) with snapin

Fumiko Suzuki, Takashi Tanaka, Shigeru Morishima, kunobu Muramatsu
Dept. Pharmacol., Fukui Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 276-276, 2005.

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The carboxy-terminus of the histamine H3 receptor interacts directly with a member of the intracellular chloride channel family

Keiko Takahashi1), Atsuo Kuramasu2), Kyohei Ariake3), Kazuhiko Yanai2), Teruyuki Yanagisawa1), Jun Sukegawa1)
1)Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med., 2)Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med., 3)Obihiro Dai-ichi Hosp.
Journal of Pharmacological Sciences 97 (suppl.2) 276-276, 2005.

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Translocation of AQP5 and CLC-K2 in the interlobular ducts of rat parotid glands stimulated by M3 muscarinic receptors

Gota Cho1), Yansu Lin2), Yoshiko Nakae3), Nobuyoshi Nakajo1), Yasuko Ishikawa2)
1)Dept. Dental Anesthesiology, Tokushima Univ., 2)Dept. of Med. Pharmacol., Tokushima Univ., 3)Dept. of Oral and Maxillofacial Anatomy, Tokushima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 277-277, 2005.

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Effects of IP3 and heparin on the fluorescence ratio of the IP3 biosensor "LIBRA"

Akihiro Nezu, Akihiko Tanimura, Takao Morita, Yosuke Tojyo
Dept. Dent. Pharmacol., Health Sci. Univ. Hokkaido
Journal of Pharmacological Sciences 97 (suppl.2) 277-277, 2005.

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Antitumor effect of amlodipine, a dihydropyridine Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo

junko Yoshida, Takaharu Ishibashi, Matomo Nishio
Dept. Pharmacol., Kanazawa Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 277-277, 2005.

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Effect of bile acids on apoptosis induced by endoplasmic reticulum stress on isolated rat hepatocytes

Shizuma Tsuchiya, Mayumi Tsuji, Shinichi Utanohara, Hideto Oyamada, Katsuji Oguchi
Dept. of Pharmacol., Sch. of Med., Showa Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 277-277, 2005.

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Partial purification of novel lectins from the dorsal spines of the reef stonefish, Synanceia verrucosa

Naoko Kono1), Takefumi Hosotani1), Masashi Miyata1), Mayumi Kayano1), Hideyuki Nakagawa1), Hiromi Sakai1), Hiromi Hayashi1), Masatoshi Nozaki2), Mitsuko Shinohara3), Kiyoshi Ohura3), Toshinori Nagasaka4)
1)Dept. Life Sci., Univ. of Tokushima, 2)Okinawa Pref. Inst. Health Environ., 3)Dept. Pharmacol., Osaka Dental Univ., 4)Fukae Nagasaka Clinic
Journal of Pharmacological Sciences 97 (suppl.2) 278-278, 2005.

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Establishment of ELISAs to quantify guinea pig total IgE and ovalbumin (OVA)-specific IgE

Makoto Nishimura1), Hiroaki Hosoe1), Hiroyuki Funaoka1), Yasuhiko Ohkaru1), Ikuhisa Yakuo2), Mari Ito3), Takahiro Masuda3), Shunya Nakamura4), Shinobu Hayakawa5), Koji Ito6)
1)Res. & Development Group, Div. of Lab. Products, 2)Dept. of Safety Pharmacol., Safety Res. Laboratories, 3)Discovery Pharmacol. I Group, Pharmacol. & Microbiology Res. Laboratories, 4)Project Planning & Management, Res. Management, Dainippon Pharmaceutical Co., Ltd., 5)Dept. of Clinical Chemistry, Maruko Pharmaceutical Co., Ltd., 6)Yugawara Koseinenkin Hosp.
Journal of Pharmacological Sciences 97 (suppl.2) 278-278, 2005.

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Role of clock gene in cholesterol/cholic acid-induced changing in CYP7a gene expression in the mouse liver

Mihoko Kawashima, Toru Tamagawa, Takashi Kudo, Shigenobu Shibata
Dept. of Pharmacol., Sch. of Sci. and Engineering Waseda Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 278-278, 2005.

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Pharmacokinetics of paroxetine and genotype of CYP2D6 polymorphisms in the Japanese patients with dose escalation

Naoko Okazaki1), Atsushi Yamauchi1), Hiroshi Nagai2), Ryouji Nishimura2), Yasufumi Kataoka1)
1)Dept. of Pharmaceut. Care and Health Sci. Fac. Pharmaceut. Sci. Fukuoka Univ., 2)Dept. of Psychiatry, Fukuoka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 278-278, 2005.

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CysLT2 signaling induces pro-apoptotic genes and apoptosis

Yoshiyuki Itoh, Toshio Tanaka
Dept. Pharmacol., Mie Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 279-279, 2005.

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A NDN/MAGE-like gene in dictyostelium discoideum

Hideo Taniura, Noriko Sanada, Yukio Yoneda
Lab. Mol. Pharma. Grad. Sch. Nat. Sci. Tech. Kanazawa Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 279-279, 2005.

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Identification of a splicing variant of rat Toll-like receptor 3 gene

Haruki Tamura, Arisa Yamada, Hiroko Saito, Shigeo Murai, Hirohisa Kato
Dep. Dental Pharmacol., Iwate Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 279-279, 2005.

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cDNA cloning and characterization of rat GPR120

Takeaki Yano, Susumu Katsuma, Akira Hirasawa, Gozoh Tsujimoto
Dept. of Genomic Drug Discovery Sci., Grad. Sch. of Pharmaceutical Sci.. Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 279-279, 2005.

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Gene expression analysis of short- and long-acting β2 adrenergic receptoragonists

Takehiko Oka, Minoru Hirano, Toshio Tanaka
Dept. Mol. and Cell. Pharmacol, Mie Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 280-280, 2005.

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Gene expression profiling in rat liver treated with omeprazole - analysis of the data in the toxicogenomics project in Japan-

Yumiko Mizukawa, Toshikazu Miyagishima, Tetsuro Urushidani, Taku Nagao
Toxicogenomics Project, Nat'l Inst. Health Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 280-280, 2005.

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Functional characterization of a novel cationic amino acid transporter (CAT5)

Yuewei Li, Taku Hirata, Naohiko Anzai, Yuji Iribe, Makoto Hosoyamada, Yoshikatsu Kanai, Hitoshi Endou
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 280-280, 2005.

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Reconstitution into liposome of organic anion transporters

Promsuk Jutabha, Naohiko Anzai, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 280-280, 2005.

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Functional analysis of genetic variants of the human organic anion transporter, OAT (SLC22A6)

Tomoe Fujita1), Maya K Leabman2), Chaline Brown2), Kazumi Fujita3), Kathleen M. Giacomini2), Masataka Majima1)
1)Dept. of Pharmacol., Kitasato Univ. Sch. of Med., 2)Dept. Pharm., Biopharmaceutical Sci., Univ. of San, 3)Dept. Int Med., Kitasato Univ. Sch. of Med
Journal of Pharmacological Sciences 97 (suppl.2) 281-281, 2005.

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Identification of a novel organic anion transporter OAT6 mediating carnitine transport in mouse liver and kidney

Naohiko Anzai, Hiroki Tsuchida, Ho Jung Shin, Ellappan Babu, Promsuk Jutabha, Keiko Sakama, Yoshikatsu Kanai, Hitoshi Endou
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 281-281, 2005.

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Identification of a novel SLC7 family member Asc-2-like transporter in kidney

Sirinun Nilwarangkoon, Taku Hirata, Yoshikatsu Kanai
Dept. Pharmacol Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 281-281, 2005.

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Identification of a testis-type organic anion transporter 1 (TOAT1)

Ellappan Babu, Taku Hirata, Naohiko Anzai, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 281-281, 2005.

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Mechanism of substrate selectivity of human organic anion transporter 1

Sudarat Nimitvilai1)2), Promsuk Jutabha1), Samaisuku Sophasan2), Hitoshi Endou1), Yoshikatsu Kanai1)
1)Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med., 2)Dept. Physiol., Mahidol Univ. Faculty of Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 282-282, 2005.

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Role of cysteine residues in the organic anion transporter mOAT1

Kunihiko Tanaka1), Fanfan Zhou2), Kogo Kuze2), Guofeng You2)
1)Dept. Pharmacol. 1, Nagasaki Univ. Grad. Sch. Biomed. So., 2)Dept. Pharm. So., Rutgers, The State Univ. NJ.
Journal of Pharmacological Sciences 97 (suppl.2) 282-282, 2005.

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Promotor analysis of human carnitine transporter (OCTN2) gene

Osamu Takikawa, Azusa Yamato, Daisuke Moli, Soichi Miwa
Dept. Pharmacol., Sch. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 282-282, 2005.

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A novel upregulator of carnitine transporter, OCTN2

Kazuhiko Nagai, Osamu Takikawa, Soichi Miwa
Dept. Pharmacol., Sch. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 282-282, 2005.

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Identification of a novel brain-type organic anion transporter 1 (BOAT1)

Taku Hirata, Ellappan Babu, Katsuko Shiraya, Naohiko Anzai, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 283-283, 2005.

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Association of TRPM2 channel with a novel EF-hand protein, EFHC1

Yuji Hara1), Aguan Kripamoy2), Masahiro Katano1), Kazuhiro Yamakawa2), Yasuo Mori1)
1)Dept. Synth. Chem. and Biol. Chem., Kyoto Univ., 2)Lab. of Neurogenet. RIKEN
Journal of Pharmacological Sciences 97 (suppl.2) 283-283, 2005.

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Purkinje cell-specific gene recombination mouse line generated from C57BL/6 strain ES cells

Teruki Hagiwara, Mika Tsujita, Manabu Abe, Kaori Akashi, Rie Natsume, Kenji Sakimura
Dept. Cell. Neurobiol., Brain Res. Inst., Niigata Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 283-283, 2005.

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Novel single nucleotide polymorphisms of α7 nicotinic receptor gene in Japanese schizophrenic patients

Soushi Kobayashi1), Hiroshi Tsuneki1), Kazue Takagi1), Syota Kagawa1), Masahiko Tsunoda2), Masahiko Murata3), Tadasu Matsuoka2), Masayoshi Kurachi2), Toshiyasu Sasaoka1), Ikuko Kimura1)
1)Dept. Clin. Pharmacol., Toyama Med. and Pharmaceutical Univ., 2)Dept. Neuropsychiatry, Toyama Med. and Pharmaceutical Univ., 3)National Hosp. Organization Hokuriku Hosp.
Journal of Pharmacological Sciences 97 (suppl.2) 283-283, 2005.

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E-cadherin is required for the gastrulation and the mophogenesis in zebrafish

Osamu Muraoka1), Taijiro Yabe2), Takashi Shimizu1), Young-Ki Bae1), Hideaki Nojima1), Masahiko Hibi1)
1)Lab. for Vertebrate Axis Formation, Riken CDB, 2)Dept. of Genetics, Univ. of Wisconsin-Madison
Journal of Pharmacological Sciences 97 (suppl.2) 284-284, 2005.

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Curcumin induces glutathione S-transferase P1 via antioxidant response element

Toru Nishinaka, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 284-284, 2005.

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Photochemical model of intrauterine growth retardation in pregnant mice

Kohhei Omatsu1), Kazunao Kondo2), Kazuo Umemura2), Naohiro Kanayama
1)Dept. Obs. & Gyn., Hamamatsu Univ. Sch. Med., 2)Dept. Pharmacol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 284-284, 2005.

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Species-specific expression of microsomal prostaglandin E synthase-1 and cyclooxygenases in male monkey reproductive organs

Nanae Nagata1), Michael Lazarus1)2), Shigeko Matsumoto1), Naomi Eguchi1)3), Yoshihiro Urade1)
1)Dept. Mol. Behav. Biol., Osaka Biosci. Inst., 2)Dept. Neurology, Harvard Med. Sch., 3)Adv. Res. Inst. for Biosci., Waseda Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 284-284, 2005.

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Stimulatory effects of eicosanoids on ovarian angiogenesis in early luteal phase in cyclooxygenase-II inhibitor-treated rats

Toshihiro Sakurai, Kazuhiro Tamura, Hiroshi Kogo
Dept. Endocrine Phrmacol., Tokyo Univ. Pharm. & Life Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 285-285, 2005.

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Inhibitory effects of amino compounds on wortmannin activities

Minoru Isosaki
Dept. Pharmacol., Nara Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 285-285, 2005.

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Evidence for paracrine modulation of voltage-dependent calcium channels in adrenal chromaffin cells

Toshio Ohta, Takahiko Kai, Shigeo Ito
Lab. Pharmacol., Dept. Biomedical Sci., Grad. Sch. Vet. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 285-285, 2005.

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Stimulatory effect of dehydroepiandrosterone sulfate ester on catecholamine secretion from bovine adrenal chromaffin cells

Kenzo Kudo, Eiichi Tachikawa, Yukiko Kondo, Kenzo Mizuma, Takeshi Kashimoto, Eiichi Taira
Dept. Pharmacol., Sch. Med., Iwate Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 285-285, 2005.

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Analysis for functional roles of vasopressin receptors in releasing adrenal hormones

Jun-ichi Birumachi, Akito Tanoue
Dept. Pharmacol., Natl. Res. Inst. Child Health Develop.
Journal of Pharmacological Sciences 97 (suppl.2) 286-286, 2005.

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Analysis of vasopressin and oxytocin receptors in secreting glucagon from mouse pancreatic islets

Yoko Kitagawa1), Masami Hiroyama1), Jun-ichi Birumachi1), Sayuri Oshikawa1), Gozoh Tsujimoto2), Akito Tanoue1)
1)Dept. Pharmacol., Natl. Ctr., Child Health Develp., Res. Inst., 2)Dept. genom. Drug. Discov. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 286-286, 2005.

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Preservation of β-cell function by DPP-IV inhibitor in ZDF rats

Wakako Toga, Naoshi Shimoji, Kaori Sasa, Satoko Tomioka, Haruyo Sugiyama, Takashi Tomoo, Nobutaka Demura, Haruko Kameda, Yusuke Nagae
Pharmacol./Toxicology group, Dept. Preclinical Development, Novartis Pharma K. K.
Journal of Pharmacological Sciences 97 (suppl.2) 286-286, 2005.

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Antidiabetic action of Bofu-tsusho-san in genetically diabetic mice (C57BL/KsJ-db/db mice)

Yukari Matsui, Yasushi Hirasawa, Shoko Ohtsu, Takahiko Nagase, Ken-ichi Yoshijima, Hitoshi Kimura, Kohei Kyuki
Nihon BioRes. Inc.
Journal of Pharmacological Sciences 97 (suppl.2) 286-286, 2005.

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Effect of plant-derived essential oil, component and kampo prescriptions on plasma ACTH, catecholamine and LH levels in experimental menopausal rats

Kenji Yamada, Yoshihiro Mimaki, Hiroji Ina
Sch. Phar., Tokyo Univ. Phar. Life Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 287-287, 2005.

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ACTH releasing activity of KP-102 in rats is mainly mediated via release of CRF

Chiharu Hirotani1), Yutaka Oki2), Kiyoharu Ukai1), Shigeru Kurasaki1), Naomi Doi3)
1)Central Res. Labs., Kaken Pharm. Co. Ltd., 2)Second Dept. Med., Hamamatsu Univ. Sch. Med., 3)Kaken Pharm. Co. Ltd
Journal of Pharmacological Sciences 97 (suppl.2) 287-287, 2005.

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Adenylyl cyclase-cAMP system inhibits thrombin-induced HSP27 in vascular smooth muscle cells

Kouseki Hirade1)2), Kumiko Tanabe1)5), Masayuki Niwa1), Akira Ishisaki1), Keiichi Nakajima1), Mitsuhiro Nakamura2), Tadashi Sugiyama2), Yoshihiro Katagiri2)3), Kanefusa Kato4), Osamu Kozawa1)
1)Dept. Pharmacol., Gifu Univ. Sch. Med., 2)Dept. Pharm., Gifu Univ. Hosp., 3)Dept. Clinic. Pharm., Gifu Univ. Grad. Sch. Med., 4)Dept. Biochem., Inst. Develop. Res., Aichi Human Service Ctr., 6)Dept. Anesthesiol. and Critical Care Med., Gifu Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 287-287, 2005.

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Transduction of Rac1 /Cdc42-inhibitory protein down-regulated proteinase-activated receptor-1 and attenuated responsiveness to thrombin in human coronary artery smooth muscle cells

Tatsuya Yufu, Katsuya Hirano, Mayumi Hirano, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol., Res Inst Angiocardiol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 287-287, 2005.

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Involvement of K+ and P450 metabolites but not H202 in decreasing the perfusion pressure with carbachol (CCh) in the rat hind limb

Shuichi Sakamoto1), Renzo Loyaga1), Takeshi Aso1), Keiko Iwasaki-Kurashige2), Hiroshi Azuma2)
1)Comprehensive Reproductive Med., Grad. Sch., Tokyo Med. & Dental Univ., 2)Dept. of Biosystem regulation, Inst. Biomaterials and Bioengineering, Grad. Sch., Tokyo Med. and Dental Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 288-288, 2005.

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Thrombin and trypsin potentiate myofilament Ca2+, sensitivity and induce contraction in pulmonary artery

Jun Maki, Katsuya Hirano, Mayumi Hirano, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol., Res. Inst. Angiocardiol., Grad. Sch. Med. Sci., Kyushu. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 288-288, 2005.

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Mechanism decreasing peripheral vascular resistance with blackcurrant concentrate (BC)

Keiko Iwasaki-Kurashige1)2), Renzo Y. Loyaga-Rendon3), Hitoshi Matsumoto2), Takahisa Tokunaga2), Hiroshi Azuma1)
1)Dept. Biosystem Regulation, Inst. Biomaterials & Bioengineering, Grad. Sch., Tokyo Med. & Dental Univ., 2)Food and Health R&D Lab., Meiji Seika Kaisha, LTD., 3)Comprehensive Reproductive Med., Grad. Sch., Tokyo Med. & Dental Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 288-288, 2005.

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Mechanisms for vasodilating actions induced by quercetin in rat aorta

Seiichiro Nishida, Hiroyasu Satoh
Dept Pharmacol., Nara Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 288-288, 2005.

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Nucleotides release are related to an action of carvedilol in porcine coronaryartery

Yasushi Sakai, Masumi Kobayashi, Budbazar Enkhjargal
Div. of Physiol., Showa Univ, Sch. of Nursing and Rehabili.
Journal of Pharmacological Sciences 97 (suppl.2) 289-289, 2005.

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Characteristics of contraction-relaxation cycle of renal artery in ovariectomized rats

Budbazar Enkhjargal, Yasushi Sakai
Div. of Physiol., Showa Univ. Sch. Nursing and Rehabili.
Journal of Pharmacological Sciences 97 (suppl.2) 289-289, 2005.

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Membrane depolarization-induced contraction and RhoA activation of rat caudal arterial smooth muscle involve genistein-sensitive tyrosine kinase

Mitsuo Mita1), Hayato Yanagihara1), Cindy Sutherland2), Shigeru Hishinuma1), Michael P. Walsh2), Masaki Saito1)
1)Dept. Pharmacodyn., Meiji Pharmaceutical Univ., 2)Dept. Biochem. & Mol. Biol. and Smooth Muscle Res. Group, Univ. Calgary
Journal of Pharmacological Sciences 97 (suppl.2) 289-289, 2005.

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Influence of endotoxemia on endothelium-dependen relaxation induced by acetylcholine and A-23187 in rat mesenteric arteries

Kazuyoshi Kunishiro, Hiroaki Shirahase, Mamoru Kanda, Hiroshi Jino, Kazuyoshi Kurahashi
Pharmacol. Div., RI Ctr., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 289-289, 2005.

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Calcium-independent PKC-DG kinase pathway is involved in a high glucose-induced dysfunction of mouse portal vein

Mari Miyatake, Koji Nobe, Kazuo Honda
Dept. Pharmacol., Showa Univ. Sch. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 290-290, 2005.

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Alteration of mouse mesenteric artery contraction under high glucose condition

Chiharu Hagiwara, Koji Nobe, Kazuo Honda
Dept. Phrmacol., Showa Univ. Sch. Pharm.
Journal of Pharmacological Sciences 97 (suppl.2) 290-290, 2005.

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Effect of blood pressure on Ephedra herb (Mao)-induced contracting and relaxing action in rat mesenteric artery

Sachie Kamiyama, Shin-ya Saito, Yasushi Ohizumi
Dept. Pharm. Mol. Biol., Grad. Sch. Pharm. Sci., Tohoku Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 290-290, 2005.

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Neural regulation of longitudinal smooth muscle in chicken posterior mesenteric artery

Takahiko Shiina, Masato Koga, Yasutake Shimizu, Tadashi Takewaki
Dept. Vet. Med., Fac. Appl. Biol. Sci., Gifu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 290-290, 2005.

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Electrophysiological properties of excitatory junctional potentials in longitudinal smooth muscle of chicken anterior mesenteric artery

Yasutake Shimizu1)2), Maisa Khalifa2), Abu Bakr El-Mahmoudy2), Takahiko Shiina1), Haruo Kobayashi2)3), Tadashi Takewaki1)2)
1)Dept. Vet. Med., Fac. Appl. Biol. Sci., Gifu Univ., 2)Unit. Grad. Sch. Vet. Sci., Gifu Univ., 3)Dept. Vet. Med., Fac. Agr., Iwate Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 291-291, 2005.

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Rho/Rho-kinase signaling-mediated contraction in aorta from apolipoprotein-E-deficient mice

Mayumi Mori1), Hiromi Tsushima1), Seigo Fujimoto1), Toyohiro Tada2), Jin-ichi Ito3)
1)Dept. Cell. Mol. Pharmacol., Nagoya City Univ., Grad. Sch. Med. Sci., 2)Dept. Pathol., Nagoya City Univ., Sch. Nurs., 3)Dept. Biochem. Cell Biol. Metabol., Nagoya City Univ., Grad. Sch. Med. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 291-291, 2005.

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Relaxant effects of Y-27632 are more potent in K+ contraction than in norepinephrine contraction in the carotid artery from spontaneously hypertensive rats (SH R)

Masahisa Asano, Yukiko Nomura
Dept. Cell. Mol. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 291-291, 2005.

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Regional difference in the relaxant effects of Y-27632 on K+-contracted strips of femoral arteries from spontaneously hypertensive rats (SHR)

Masahisa Asano, Yukiko Nomura
Dept. Cell. Mol. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 291-291, 2005.

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Involvement of cysLT and LTB4 in vasopressin-induced contraction of rat basilar artery

Cristina C. Trandafir, Tsuyoshi Nishihashi, Xu Ji, Aimin Wang, Kazuyoshi Kurahashi
Pharmacol. Div., RI Ctr., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 292-292, 2005.

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Influence of experimental SAH on effects of PLA2 and PLC inhibitors in nicotine-induced endothelium-dependent contraction (EDC) in rat basilar artery

Xu Ji, Tsuyoshi Nishihashi, Cristina C. Trandafir, Aimin Wang, Kazuyoshi Kurahashi
Pharmacol. Div., RI Ctr., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 292-292, 2005.

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Enhanced reactivity of vasopressin in rat basilar arteries after subarachnoid hemorrhage

Tsuyoshi Nishihashi, Cristina. C. Trandafir, Xu Ji, Aimin Wang, Kazuyoshi Kurahashi
Pharmacol. Div., RI Ctr., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 292-292, 2005.

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Changes in K-channel and electrogenic sodium pump activities of rat basilar artery after SAH-induction

Kazuyoshi Kurahashi, Tsuyoshi Nishihashi, Cristina. C. Trandafir, Xu Ji, Aimin Wang
Pharmacol. Div., RI Ctr., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 292-292, 2005.

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Effects of cyclohexenonic long-chain fatty alcohol on STZ-induced diabetic rat aorta

Yukako Kinoshita1), Motoaki Saito1), Itaru Satoh1), Tomoharu Kono1), Hiroto Suzuki2), Masashi Yamada2), Keisuke Satoh1)
1)Dept. of Pathophysiological and Therapeutic Sci., Div. of Mol. Pharmacol., Tottori Univ. Faculty of Med., 2)Meiji Dairies Corporation Pharmaceuticals Dept.
Journal of Pharmacological Sciences 97 (suppl.2) 293-293, 2005.

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Possible involvement of angiotensin II in enhanced norepinephrine response in high-dose insulin treatment diabetic aorta

Yuko Hayashi, Tsuneo Kobayashi, Takayuki Matsumoto, Katsuo Kamata
Dept. Physiol. Morphol., Inst. Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 293-293, 2005.

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Characterization of vasomotor activity in mesenteric artery from STZ-induced diabetic and cholesterol-fed mice

Kiyoto Miyamori, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept. Physiol. Morphol., Inst. Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 293-293, 2005.

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Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats

Kentaro Wakabayashi, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept. Physiol. Morphol., Inst. Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 293-293, 2005.

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Impaired vasomotor activity in isolated basilar artery from type II diabetic rats

Shintaro Yoshiyama, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept. Physiol. Morphol., Inst. Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 294-294, 2005.

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Attenuation of the cardiac function and calcium handling in streptozotocin (STZ)-induced diabetic mice

Kana Namiki, Tomonori Nakamura, Shingo Yano, Kageyoshi Ono
Dept. Mol. Pharmacol. Pharmacother., Grad. Sch. Pharm. Sci., Chiba. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 294-294, 2005.

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Cardiovascular effects of mitiglinide calcium dehydrate: Comparison with glibenclamide and glimepiride (sulfonylureas)

Itaru Maruyama, Yoshitaka Tomiyama, Kazuyasu Maruyama, Kazuma Ojima, Kumi Kobayashi, Mamoru Kobayashi, Yoshinobu Yamazaki, Masami Kojima, Nobuo Shibata
Pharmacol. Res. R&D, Kissei Pharmaceutical. Co., Ltd.
Journal of Pharmacological Sciences 97 (suppl.2) 294-294, 2005.

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Effects of specific signal transduction inhibitors on increased permeability induced by neuropeptide Y or VEGF

Zhi-Yong Chen1), Yong-Shan Nan1), Nakako Kurimoto2), Guo-Gang Feng1), Toru Komatsu2), Yasuhiro Shimada1), Naohisa Ishikawa1)
1)Dept. Pharmacol., Aichi Med. Univ., 2)Dept. Anesthesiology, Aichi Med. Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 294-294, 2005.

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The interaction between nitric oxide and thromboxane A2 in cultured porcine basilar arterial endothelial cells

Atsushi Miyamoto, Yoriko Hashiguchi, Akira Nishio, Shigeru Ishiguro
Dept. Vet. Pharmacol., Fac. Agri., Kagoshima Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 295-295, 2005.

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Ca2+ response of endothelial cell at various regions in renal artery induced by shear stress in the presence of lysophosphatidic acid

Sanae Ando, Masayuki Yamamoto, Kazutaka Momose, Kazuo Honda, Hisayuki Ohata
Dept. Pharmacol., Sch of Pharm. Sci., Showa Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 295-295, 2005.

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The effect of laminar shear stress on CYP1A1 expression and activity in vascular endothelial cells

Zhiyi Han, Yoshikazu Miwa, Toshiyuki Sasaguri
Dept. Clinical Phamacol., Grad. Sch. of Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 295-295, 2005.

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The membrane trafficking plays an important role in maintaining the surface expression of proteinase-activated receptor-1 in vascular smooth muscle cells

Wakako Eto, Mayumi Hirano, Katsuya Hirano, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol., Res Inst Angiocardiol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 295-295, 2005.

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RhoA plays a key role in regulating NO production in in situ endothelial cells

Noriko Shiga, Katsuya Hirano, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol., Res. Inst. Angiocardiol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 296-296, 2005.

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Inhibition of RhoA expression by TGFβ1, in bovine aortic endothelial cells

Michi Watanabe, Masahiro Oike, Yushi Ito
Dept. Pharmacol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 296-296, 2005.

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Involvement of prostanoid(s) produced via the COX-1 pathway in NO-induced vasodilation of the rat eyegrounds

Masami Hasebe, Maki Saito, Asami Mori, Yoshiko Kaneko, Naoto Ogawa, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 97 (suppl.2) 296-296, 2005.

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Antagonizing effect of plasmin on the thrombin-induced endothelium-dependent relaxation in coronary artery

Tetsuhiro Fujiyoshi, Katsuya Hirano, Mayumi Hirano, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol., Res Inst. Angiocardiol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 296-296, 2005.

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Neuropeptide Y-induced potentiation of serotonin-mediated contraction in the porcine coronary artery: involvement of endothelium-generated thromboxane A2

Tatsuru Tsurumaki, Shingo Nagai, Hiroshi Higuchi
Div. Pharmacol., Grad. Sch. Med. Dent. Sci., Niigata Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 297-297, 2005.

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Neuropeptide Y-induced contraction and synergistic action in cerebral arteries and ciliary arteries

Shingo Nagai, Tatsuru Tsurumaki, Hiroshi Higuchi
Div. Pharmacol., Gad. Sch. Med. Dent. Sci., Niigata Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 297-297, 2005.

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NO-dependent cGMP production is downregulated through a type 1 angiotensin II receptor (AT1R)-mediated increase in superoxide production in rabbit mesenteric artery after long-term in vivo administration of nitroglycerine

Junko Kajikuri1), Yoshikatsu Suzuki2), Nobuyoshi Kusama1), Tamao Yamamoto1), Takeo Itoh1)
1)Dept. Pharmacol., Nagoya City Univ. Sch. Med., 2)Dept. Obstet. & Gynecol., Nagoya City Univ. Sch. Med.
Journal of Pharmacological Sciences 97 (suppl.2) 297-297, 2005.

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Chronic nitroglycerine administration reduces endothelial nitric oxide production in rabbit mesenteric resistance artery

Tamao Yamamoto1)2), Yoshikatsu Suzuki2), Takeo Itoh1)
1)Dept. Mol. Cell. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ., 2)Dept. Hum. Reprod. Embryol., Grad. Sch. Med. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 297-297, 2005.

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Vasoconstrictor role and mRNA expression of each α1-AR subtype in mouse vessels

Chihiro Hosoda1), Akito Tanoue1), Mari Shibano2), Yoshio Tanaka2), Taka-aki Koshimizu3), Gozoh Tsuiimoto3), Katsuo Koike2)
1)Dept. Mol. Cell Pharmacol., Natl. Ctr., Child Health Develp., Res. Inst, 2)Dept. Chemi Pharmacol., Toho Univ. Sch. Pharma, 3)Dept. Genom. Drug. Discov. Sci., Kyoto Univ. Grad. Sch. Pharmac. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 298-298, 2005.

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Pharmacome analysis of α1L-adrenoceptor in rabbit ear artery

Yasuko Hiraizumi, Shigeru Morishima, Fumiko Suzuki, Hatsumi Yamamoto, Takashi Tanaka, Ikunobu Muramatsu
Div. Pharmacol., Dept. Biochem. Bioinformat. Sci., Med. Sch., Univ. Fukui
Journal of Pharmacological Sciences 97 (suppl.2) 298-298, 2005.

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Apelin-induced chemotaxic migration of retinal endothelial cells

Maki Oda1), Norihito Shintani1), Atsushi Kasai1), Michiya Kakuda1), Hitoshi Hashimoto1), Toshio Matsuda2), Akemichi Baba1)
1)Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2)Lab. Med. Pharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ.
Journal of Pharmacological Sciences 97 (suppl.2) 298-298, 2005.

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