Journal of Pharmacological Sciences 100巻 suppl.1号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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PL3 Molecular Basis of Muscular Dystrophy and Therapeutic Strategies

Kevin P. Campbell
University of Iowa College of Medicine, U. S. A.
Journal of Pharmacological Sciences 100 (suppl.1) 3-3, 2006.

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PL4 Glutamate receptors - dynamic struc-ture and subunit-specific signaling

Morgan Sheng
Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, USA
Journal of Pharmacological Sciences 100 (suppl.1) 3-3, 2006.

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PL5 Prostanoid receptors; from cDNA cloning to translational research

Shuh Narumiya
Kyoto University Faculty of Medicine, Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 4-4, 2006.

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IL1 Pharmacogenomics of opioid drugs

Andrew Somogyi
Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia
Journal of Pharmacological Sciences 100 (suppl.1) 6-6, 2006.

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IL2 Metabolic syndrome - pathogenesis and treatment strategy

Takashi Kadowaki
Dept. of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 6-6, 2006.

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IL3 Self-renewal of neural stem cells and CNS-repair

Hideyuki Okano
Department of Physiology, Keio University School of Medicine, SORST JST Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 7-7, 2006.

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EL1 GABAB receptor - structure and func-tion in alimentary tract

Kohtaro Taniyama
Dept. Pharmacol. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 10-10, 2006.

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EL2 Pharmacological basis of traditional medicine as curative polypharmacy in the 21st century

Takeshi Miyata
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 10-10, 2006.

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EL3 Do drugs suppress lethal arrhythmias?

Keitaro Hashimoto
Department of Pharmacology, Interdisciplinary Graduate Sch Medicine Engineering, Univ of Yamanashi, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 11-11, 2006.

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KL1 In search of new chemotherapy for cancer using mouse models

Makoto Mark Taketo
Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 14-14, 2006.

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KL2 Schizophrenia and the mode of functions of the risk factors in neurons

Kozo Kaibuchi
Department of Cell Pharmacology Nagoya University Graduate School of Medicine, Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 14-14, 2006.

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AL1 Structural and physiological plasticity of hippocampal mossy fibers

Yuji Ikegaya
Grad School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 16-16, 2006.

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AL2 Mitochondrial dysfunction and apop-tosis in neurodegenerative diseases

Kazuhiro Takuma
Lab. Neuropsychophannacol. , Div. Life Sci. , Grad. Sch. Nat. Sci. Technol. , Kanazawa Univ. , Kanazawa , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 16-16, 2006.

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AL3 Visualization of intracellular Ca2+ signaling

Kenzo Hirose
Department of Cell Physiology, Nagoya University Graduate School of Medicine, Naoya, Aichi , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 17-17, 2006.

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S1A1-1 Functional analysis of DISC1 and DYSBINDIN - candidate genes for schizo-phrenia -

Shinsuke Matsuzaki1, 2), Masaya Tohyama1, 2)
1)Dept. Anatomy and Neuroscience. , Graduate School of Medicine Osaka University, Osaka , Japan,, 2)21th COE program, Osaka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 20-20, 2006.

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S1A1-2 Susceptibility genes for schizo-phrenia and intermediate phenotype

Ryota Hashimoto
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 20-20, 2006.

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S1A1-3 PACAP knockout mice: A new model for psychomotor dysfunction

Hitoshi Hashimoto1, Norihito Shintani1, Yukio Ago1, 2, Toshio Matsuda2, Akemichi Baba1
1Lab. Mol. Neuropharmacol. , Grad. Sch. Pharmaceut. So, Osaka Univ. , Osaka , Japan,, 2Lab. Medicinal Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 20-20, 2006.

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S1A1-4 Investigating signal transduction and genes-to-behaviors pathways in psychi-atric diseases

Tsuyoshi Miyakawa
HMRO. Kyoto Univ. Med. , Kyoto , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 20-20, 2006.

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S1A1-5 Animal models of schizophrenia for the development of new therapies

Norio Mori, Katsuaki Suzuki, Yasuhide Iwata, Hideo Matsuzaki, Takashi Watanabe, Tomoyasu Wakuda, Motoyoshi Dote
Dept. Psychiatry & Neurology, Hamamatsu Univ. Sch Med. , Hamamatsu-shi , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 21-21, 2006.

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S1B1-1 RNAi library using EPRIL technology

Kenzo Hirose
Dept. Cell Physiol. , Nagoya Univ. Sch. Med. , Aichi , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 21-21, 2006.

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S1B1-2 Biochemical characterization of RNAi and miRNA pathways in drosophila

Mikiko Siomi
Inst. Genome Res. , Univ. Tokushima, Tokushima , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 21-21, 2006.

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S1B1-3 Recent progress in RNAi drug discovery

Junichi Yano
Div. R&D, Nippon-Shinyaku Co. , Ltd, Kyoto , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 21-21, 2006.

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S1B1-4 Selection of highly effective and target specific siRNA sequences for mam-malian RNAi

Kumiko Ui Tei1, Yuki Naito1, Tomoyuki Yamada2, Shinichi Morishita2, Kaoru Saigo1
1Dept. Biophys. Biochem. , Grad. Sch. Sci. , Univ. Tokyo, Tokyo , Japan,, 2Dept. Computatinal Biol. , Grad. Sch. Frontier Sci. , Univ. Tokyo, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 22-22, 2006.

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S1C1-1 Recent advances in SLC22 organic anion transporters

Yoshikatsu Kanai, Hitoshi Endou
Dept. Pharmacol. and Toxicol. , Kyorin Univ. Sch. Med. , Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 22-22, 2006.

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S1C1-2 Effect of Pregnane X Receptor lig-and on expression of organic cation transporter OCT1

Ikumi Tamai, Tomoji Maeda
Dept. Mol. Biopharmaceut. , Tokyo Univ. Sci. , Fac. Pharm. Sci. , Chiba , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 22-22, 2006.

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S1C1-3 Functional analysis of human ABCC4/MRP4 transporter by multichannel LC-MS/MS

Tetsuya Terasaki1, 2, Junichi Kamiie1, 2, Yasuo Uchida1, 2, Ayanobu Yagami3, Hikaru Yabuuchi3, Sumio Ohtsuki1, 2
1Membrane Transport & Drug Targeting Lab. , Grad. Sch. Pharm. Sci. , Tohoku Univ. , Sendai , Japan,, 2NICHe, Tohoku Univ. , Sendai , Japan,, 3Genomembrane, Yokohama , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 22-22, 2006.

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S1C1-4 Hepatic and intestinal transporters as drug targets

Hiroshi Suzuki
Dept. Pharmacy, The Univ. of Tokyo Hospital, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 23-23, 2006.

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S1D1-1 Functional roles of nitrergic nerve innervating cerebral artery

Kazuhide Ayajiki
Dept. Pharmacol. , Shiga Univ. Med. Sci. , Otsu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 23-23, 2006.

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S1D1-2 S-glutathiolation in nitric oxide signaling

Takeshi Adachi
Department of Biochemistry & Integrative Medical Biology, School of Medicine, Keio University, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 23-23, 2006.

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S1D1-3 Mechanisms of nitric oxide production from dietary nitrite

Koichiro Tsuchiya1, Yasuhisa Kanematsu2, Hideki Ohnishi2, Soichiro Tajima1, Kazuyoshi Kawazoe3, Shinji Abe3, Yoshiharu Takiguchi1, Toshiaki Tamaki2
1Dept. Clin. Pharmacol. , Inst. Health Biosci. , Univ. Tokushima Grad. School, Tokushima , Japan,, 2Dept. Pharmacol. , Inst. Health Biosci. , Univ. Tokushima Grad. School, Tokushima , Japan,, 3Dept. Pharmacy, Tokushima Univ. Hosp. , Tokushima , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 23-23, 2006.

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S1D1-4 Rational design of novel fluorescence probes for various reactive nitrogen species

Yasuteru Urano
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 24-24, 2006.

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S1D1-5 Generation and functional evaluation of mice lacking all nitric oxide synthase isoforms

Masato Tsutsui1), Hiroaki Shimokawa2), Tsuyoshi Morishita3), Sei Nakata3), Yasuhide Nakashima3), Nobuyuki Yanagihara1)
1)Dept. Pharmacol. , Sch. Med. , Univ. Occup. & Envrn. Hlth, 1-1 , Kitakyushu , Japan,, 2)Dept. Cardiovasc. Med. , Tohoku Univ. Grad. Sch. Med. , Sendai , Japan,, 3)2nd Dept. Int. Med. , Sch. Med. , Univ. Occup. & Envrn. Hlth, Kitakyushu , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 24-24, 2006.

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S1A2-1 Identification and characterization of putative species-specific transcripts and promoters using full-length cDNA resources

Yutaka Suzuki1, Yasuhiro Uno2, Kenta Nakai3, Sumio Sugano1
1Dept Medical Genome Sciences, Grad Sch of Frontier Sci, Univ of Toyko, Chiba , Japan,, 2Grad Sch Pharm Sci, Hokkaido Univ, Sapporo, Japan, 3IMS, Univ of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 24-24, 2006.

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S1A2-2 Reverse proteomics based on the ORFeome construction in the fission yeast Schizosaccharomyces pombe

Akihisa Matsuyama, Yoko Yashiroda, Ritsuko Arai, Atsuko Shirai, Minoru Yoshida
Chemical Genetics Laboratory, RIKEN, Saitama , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 24-24, 2006.

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S1A2-3 University compound project

Akira Okuyama
Foundation for Education of Science and Technology, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 25-25, 2006.

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S1A2-4 Development of basal techniques for identification of specific binding proteins using affinity resins bearing bioactive compounds

Akito Tanaka
Reverse Proteomics Research Institute Co. , Ltd. , Chiba , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 25-25, 2006.

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S1A2-5 Development of an integrated database of drug sensitivity and gene expression for the molecular pharmacology of cancer

Shingo Dan, Takao Yamori
Division of Molecular Pharmacology, The JFCR Cancer Chemotherapy Center, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 25-25, 2006.

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S1A2-6 System identification based on genome resources, genome information and high-throughput transfection technology

Hiroki Ueda
Laboratory for Systems Biology and Functional Genomics Subunit, CDB, RIKEN, Kobe, , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 25-25, 2006.

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S1B2-1 Adenosine A2A receptor antago-nists as novel non-dopaminergic therapy for Parkinson's disease: a potential mechanism of the anti-parkinsonian action

Akihisa Mori
Pharmaceutical Research & Development Division, Kyowa Hakko Kogyo Co. , Ltd. , Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 26-26, 2006.

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S1B2-2 Astrocyte-to-pericytes interaction mediated by P2 receptors; regulation of microcirculation in the CNS?

Schuichi Koizumi1, Kayoko Fujishita1, Koji Sueishi1, 2, Fuyuko Takata2, Yasufumi Kataoka2
1Div. Pharmacol. , Natl. Inst. Hlth. Sci. , Tokyo , Japan,, 2Dept. Pharmaceut. Care Hlth. Sci. , Fukuoka Univ. , Fukuoka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 26-26, 2006.

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S1B2-3 Brain chemokine production through the glial purinergic receptor activation

Masabumi Minami
Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Hokkaido Univ. , Sapporo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 26-26, 2006.

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S1B2-4 Role of factors upregulating P2X4 expression in the pathogenesis of neuropathic pain

Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyushu Univ. , Fukuoka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 26-26, 2006.

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S1B2-5 Purinoceptor modulation of potentiated synaptic transmission in the central amygdala of the rat with neuropathic pain

Fusao Kato, Nami Hasegawa, Ryo Ikeda
Lab. Neurophysiol. , Dept. Neurosci. , Jikei Univ. Sch. Med. , Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 27-27, 2006.

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S1C2-1 Endocrine disruptors and LD /ADHD /autism spectrum disorders; PCBs and other environmental chemicals are possible causal factors of the developmental disorders through disruption of gene expressions

Yoichiro Kuroda1, 2
1Dept. Mol. Cel. Neurobiol. , Tokyo Metropol. Inst. Neuroscience, Tokyo , Japan,, 2CREST, Saitama , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 27-27, 2006.

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S1C2-2 Effect of environmental chemicals on neurobehavioral functions - experimental and field approaches

Chiho Watanabe
Dept Human Ecology, Grad Sch Mcd, Univ. Tokyo, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 27-27, 2006.

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S1C2-3 Effects of organo-arsinic compounds on central nervous systems

Kazuhiro Ishii1, Tohoru Takeda2, Nobuaki Iwasaki3, Kenji Ishii4, Hideo Tsukada5, Akira Tamaoka1
1Dept. Neurol. , Inst. Clin. Med. , Grad. Sch. Compre. Hum. Sci. , University of Tsukuba, Ibaraki, Japan,, 2Dept. Rad. , Inst. Clin. Med. , Grad. Sch. Compre. Hum. Sci. , University of Tsukuba, Ibaraki, Japan,, 3Dept. Pediat. , Ibaraki Prefectural University of Health Sci. , Ibaraki, Japan,, 4Positron Medical Center, Tokyo Metropolitan Inst. Geront. , Tokyo, Japan,, 5PET Cent. , Cent. Res. Lab. , Hamamatsu Photonics K. K. , Shizuoka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 27-27, 2006.

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S1C2-4 DES may have a definitive time window for producing brain disrupting actions in mice

Taku Kaitsuka1, Fumio Soeda1, Kazuya Tomihara2, Tomoko Soga3, Donald. D. Pfaff3, Sonoko Ogawa3, 4, Dennis. B. Lubahn5, Pierre Chambon6, Tetsuya Shirasaki1, Kazuo Takahama1
1Dept. Environ. & Molec. Health Sci. , Grad. Sch. Pharm. Sci. , Kumamoto Univ. , Kumamoto , Japan,, 2Dept. Psychol. , Fac. Law, Econom. & Human. , Kagoshima Univ. , Kagoshima , Japan,, 3Lab. Neurobiol. & Behav. , Rockefeller Univ. , New York , USA,, 4Kansei & Cognitive Brain Sci. , Grad. Sch. Comprehens. Hum. Sci. , Univ. of Tsukuba, Ibaraki , Japan,, 5Dept. Molec. Biol. , Missouri Univ. , Missouri , USA, 6IGBMC, ICS, CNRS/INSERM/ULP, College de France, lllkrich Cedex , France
Journal of Pharmacological Sciences 100 (suppl.1) 28-28, 2006.

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S1C2-5 Dynamic changes in dopaminergic neurotransmission induced by a low concentration of bisphenol-A in neurons and astrocytes

Kazuya Miyagawa, Minoru Narita, Mayumi Miyatake, Hisahiko Akama, Mariko Tomita, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 28-28, 2006.

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S1C2-6 Influences of environmental estro-genic chemicals on catecholamine synthesis

Yumiko Toyohira1, Susumu Ueno1, Masato Tsutsui1, Kojiro Takahashi2, Nobuyuki Yanagihara1
1Dept. Pharmacol. , Univ. of Occup. & Environ. Health, Sch. Med. , Kitakyushu , Japan,, 2Dept. Hosp. Pharm. , Univ. of Occup. & Environ. Health, Kitakyushu , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 28-28, 2006.

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S1D2-1 Regulation of histamine signaling-related gene expression in allergy

Hiroyuki Fukui
Dept. Mol. Phannacol. , Inst. HBS, The Univ. Tokushima Grad. Sch. , Tokushima , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 28-28, 2006.

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SID2-2 Regulation of allergic airway inflammation through toll like receptor 4-mediated modification of mast cell function

Masakatsu Yamashita, Toshinori Nakayama
Dept. Immunol. , Chiba Univ. Grad. Sch. Med. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 29-29, 2006.

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S1D2-3 Signal regulation for distinct mast cell responses through Fc ε RI

Sho Yamasaki
Cell Signaling, RCAI, RIKEN, Yokohama , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 29-29, 2006.

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S1D2-4 Systemic approach to mast cell biology in allergic diseases

Hirohisa Saito1, 2
1Dept. Allergy & Immunol. , National Research Institute for Child Health & Development, Tokyo , Japan,, 2Allergy Transcriptome Unit, RCAI, RIKEN, Kanagawa , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 29-29, 2006.

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S1D2-5 The role of histamine in allergic reactions from the study of histidine decar-boxylase gene-knockout mice

Hiroshi Ohtsu
Dept. Applied Quantum Medical Engineering, Tohoku Univ. Sch. Eng. , Sendai , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 29-29, 2006.

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S1D2-6 The role of histamine in goblet cell hyperplasia in the murine asthma model

Kohei Yamauchi1, Hong Mei Piao1, Toshiki Shikanai1, Hiroshi Inoue1, Hiroshi Ohtsu2, Masahito Ogasawara3
1Third Dept. Int. Med. Iwate Med. Univ. Sch. Med. , Morioka , Japan,, 2Graduate School of Engineering, Applied Quantum Medical Engineering, Tohoku University, Sendai, Japan,, 3Department of Pharmacology, Ehime University School of Medicine, Toon city, Ehime prefecture, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 30-30, 2006.

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S1A3-1 New fluorescent probes and new perspectives in pharmacological science

Atsushi Miyawaki, Hiroshi Hama, Hideaki Mizuno, Asako Sawano, Ryoko Ando, Takako Kogure
Lab, for Cell Function Dynamics, Brain Science Institute, RIKEN, Saitama , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 30-30, 2006.

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S1A3-2 Toward functional imaging of whole living organisms

Takeharu Nagai
Nanosystems Physiology Lab. , RIES, Hokkaido Univ. , Sapporo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 30-30, 2006.

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S1A3-3 Functional analysis of cell-cell repulsion using surface reflection interference contrast (SRIC) and total internal reflection fluorescence (TIRF) microscopy

Masaya Hashido, Masamitsu Iino
Dept. Pharmacol. , Univ. Tokyo, Grad. Sch. Med. , Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 30-30, 2006.

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S1A3-4 Development of new technique for imaging living mice using fluorescent proteins

Yoshihiro Miwa1, 2, Junko Tanaka1, Naoki Yoshida1, Katsutoshi Goto1
1Dept. Pharmacol. , Grad. Sch. CHS. , Univ. Tsukuba. , Tsukuba , Japan,, 2PRESTO. , JST, Tsukuba , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 31-31, 2006.

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S1B3-1 Evaluation of the effect of hypnotics in a new sleep-disturbed rats

Kazuaki Shinomiya1, 2, 3, Naomi Eguchi1, 2, Chiaki Kamei3
1Adv. Res. Inst. for Biosci. , Waseda Univ. , Tokyo , Japan,, 2Waseda-Olympus Biosci. Res. Inst. , Biopolis Way, Singapore,, 3Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 31-31, 2006.

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S1B3-2 Novel model mice for sleep disorders and their applications

Naomi Eguchi1, 2, 3, Zhi Li Huang3, Yoshihiro Urade3
1Adv. Res. Inst. for Biosci. , Waseda Univ. , Tokyo , Japan,, 2Waseda-Olympus Biosci. Res. Inst. , , Singapore,, 3Dept. of Mol. Behav. Biol. , Osaka Biosci. Inst. , Osaka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 31-31, 2006.

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S1B3-3 Juvenile SHRSP/Ezo, an animal model for AD/HD

Hiroko Togashi1, 2, Taku Yamaguchi1, Machiko Matsumoto1, Mitsuhiro Yoshioka1
1Dept. Neuropharmacol. , Hokkaido Univ. Grad. Sch. Med. , Sapporo , Japan,, 2Dept. Clin. Physiol. , Fac. Pharm. Sci. , Hlth. Sci. Univ. Hokkaido, Hokkaido , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 31-31, 2006.

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S1B3-4 Altered amygdala neuronal circuits and enhanced fear response in dystrophin-deficient mice

Masayuki Sekiguchi
Dept. Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 32-32, 2006.

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S1B3-5 Novel therapeutic targets for anti-depressants: a study on olfactory bulbec-tomized rats

Akiyoshi Saitoh1, Mitsuhiko Yamada2, Misa Yamada2, Kou Takahashi2, Noritake Hirose1, junzo Kamei1
1Dept. Pathophysiol. Ther. , Sch. Pharrn. Pharm. Sci. , Hoshi Univ. , Tokyo, Japan,, 2Dept. Psychogeriatr. , NINH. , NCNP. , Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 32-32, 2006.

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S1B3-6 Identification of susceptibility genes for bipolar disorder and its potential applications

Eiji Hattori, Noriaki Nakatani, Takeo Yoshikawa
Lab for Moleclular Psychiatry, RIKEN BSI, Saitama , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 32-32, 2006.

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S1C3-1 Approach of in vitro study to evaluate the efficacy and safety of medicines

Yuji Yoshiyama
Div. Clinical Pharmacy, Kyoritsu Univ. Pharmacy, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 32-32, 2006.

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S1C3-2 Assessment of antioxidant property of drugs using electron spin resonance (ESR) spectroscopy

Masaichi-Chang-il Lee
Dept. Clinical Care Medcine, Kanagawa Dental College, Yokosuka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 33-33, 2006.

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S1C3-3 Evaluation of neuroprotective drugs by electron spin resonace (ESR)

Yukio Ikeda
Department of Neurosurgery, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 33-33, 2006.

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S1C3-4 Advantages and limitations of a new coculture system using small intestine-and liver-derived cells

Yasuyuki Sakai1, 2, Masaki Nishikawa2, Nobuhiko Kojima2, Emiko Kitagawa3, Takatoki Yamamoto2, Hitoshi Iwahashi3, Teruo Fujii2
1Center Dis. Biol. Integ. Med. , Grad. Sch. Med. , Univ. Tokyo, Tokyo , Japan,, 2Inst. Ind. So. , Univ. Tokyo, Tokyo , Japan,, 3Nat. Inst. Adv. Ind. Sci. Technol. , lbaragi , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 33-33, 2006.

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S1C3-5 Current status of in vitro methods for safety evaluation of a chemical by industries

Satoshi Kawamura
Environmental Health Science Laboratory, Sumitomo Chemical Co. , Ltd. , Osaka , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 33-33, 2006.

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S1C3-6 Effects of medicine on rat cultured embryos

Atsushi Yokoyama1, 2
1Kanagawa Life-science Res. , Kanagawa , Japan,, 2Bortimoa Env. Tec. Center, Bortimoa, USA
Journal of Pharmacological Sciences 100 (suppl.1) 34-34, 2006.

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S1D3-1 Microglial contribution in neuro-pathic pain: Involvement of ATP receptors

Kazuhide Inoue
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 34-34, 2006.

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S1D3-2 Regulatory role of prostaglandin terminal synthases in upper airway inflammation

Mitsuhiro Okano, Rie Matsumoto, Tazuko Fujiwara
Dept. Otolaryngol. , Okayama Univ. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 34-34, 2006.

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S1D3-3 Roles of lymphocytic cholinergic system in regulation of lymphocyte function

Koichiro Kawashima
Dept. Pharmacol. , Kyoritsu Coll. Pharmacy, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 34-34, 2006.

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S1D3-4 Regulation of innate immune response by inducible histamine: Analysis on mouse hepatitis model

Masahiro Nishibori, Hideo Takahashi, Shuji Mori
Dept. Pharmacol. , Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 35-35, 2006.

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S2A1-1 Development of anti-allergic drug by collaboration between the NPO Bio Grid and SOSHO projects

Tsuyoshi Inoue
Dep. of Applied Chemistry, Grad. Sch. of Engineering, Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 35-35, 2006.

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S2A1-2 New generation of the in-silico screening method

Yoshifumi Fukunishi
BIRC, AIST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 35-35, 2006.

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S2A1-3 An in silico prediction system of the risk of drug-induced cardiac arrhythmia

Yoshihisa Kurachi1, 2
1The Center for Advanced Medical Engineering and Informatics, Osaka Univ. , Osaka, Japan,, 2Dept. Pharmacol. , Grad. Sch. of Med. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 35-35, 2006.

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S2A1-4 Biosimulation-assisted prediction of different outcomes of anti-platelet reagents and its demonstration in vivo

Makoto Suematsu
Dept. of Biochem. & Integr. Med. Biol, Sch. of Med. , Keio Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 36-36, 2006.

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S2B1-1 Surveillance from the viewpoint of gender differences about the actual use of prescription drugs

Koichi Ueno
Dept. Geriat. Pharmacol. Ther. , Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 36-36, 2006.

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S2B1-2 Sex-related difference of cytochrome P450 and its molecular mechanism

Tetsuya Kamataki
Div. Drug Metab. , Grad. Sch. Pharm. Sci. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 36-36, 2006.

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S2B1-3 Hormonal regulation of cytodifferention of branching morphogenesis and expression of retinoic acid receptor in fetal mouse submandibular glands

Shichiro Maruyama1, Takahiro Naka2, Takahide Nagao1, Hiroshi Sakagami1, Syuji Ohkawa2, Kinji Kuhara3, Keiichi Tonosaki3, Masanori Kashimata4, Edward Gresik5
1Dept. Pharmacol. Meikai Univ. Sch. Dent. , Saitama, Japan,, 2Dept Prosthodo. Meikai Univ. Sch. Dent. , Saitama, Japan,, 3Dept. Physol. Meikai Univ. Sch. Dent. , Saitama, Japan,, 4Dept. Dent. Pharmacol. Asahi Univ. Sch. Dent. , Gifu, Japan,, 5Dept Cell Bio. & Anat. Sci. , City NY Univ. Sch. Med. , NY, U. S. A.
Journal of Pharmacological Sciences 100 (suppl.1) 36-36, 2006.

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S2B1-4 Gender differences in allergic reactions

Naoki Inagaki, Hiroyuki Tanaka, Hiroichi Nagai
Dept. Pharmacol. , Gifu Pharm. Univ. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 37-37, 2006.

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S2B1-5 Gender medicine and kanpo

Yuko Kinoshita
Dept. Oriental Med. , Nihon Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 37-37, 2006.

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S2C1-1 Plants as unique model systems to evaluate drug efficacy and to search new pharmacological targets

Hirofumi Kai
Dept. Mol. Med. , Fac. Med. Pharma. , Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 37-37, 2006.

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S2C1-2 Genetic dissection of neurode-generative signals in Drosophila

Masayuki Miura
Dept. Genetics, Grad. Sch. Pharma. Sci. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 37-37, 2006.

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S2C1-3 Analysis on the mechanisms of reproductive organ formation; model systems as mice, fish and chick embryos

Gen Yamada
CARD, Kumamoto University, Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 38-38, 2006.

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S2C1-4 Behavioral genetics in C. elegans -the roles for the insulin/PI 3-kinase pathway in behavioral plasticity

Yuichi Iino, Masahiro Tomioka, Takeshi Adachi, Daisuke D. Ikeda, Hirofumi Kunitomo
Mol. Genet. Res. Lab. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 38-38, 2006.

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S2C1-5 Molecular analysis of higher brain formation using ferrets

Hiroshi Kawasaki
Dept. Mol. System Neurobiol. , Univ. Tokyo Grad. Sch. Med, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 38-38, 2006.

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S2D1-1 Regulatory mechanism of Ca 2+/calmodulin-dependent protein kinase I β32

Yasuhito Naito
Dept. Pharmacol. , Kitasato Univ. Sch. Parmac. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 38-38, 2006.

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S2D1-2 Involvement of CaM kinase II in pathophysiology of Alzheimer's disease

Hideyuki Yamamoto
Dept. Mol. Pharmacol. , Kumamoto Univ. Sch. Med. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 39-39, 2006.

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S2D1-3 The role of Ca2+/calmodulin-dependent protein kinase II in epilepsy

Yoko Yamagata1, 2
1Natl. Inst. for Physiol. Sci. , Okazaki, Japan,, 2SOK-ENDAI, Okazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 39-39, 2006.

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S2D1-4 Expression and functional signifi-cance of Ca2+/calmodulin-dependent protein kinase I during neuronal development

Hiroyuki Sakagami
Dept. Cell Biology, Tohoku Univ. Grad. Sch. Med. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 39-39, 2006.

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S2D1-5 Regulation of the ASK1-p38 MAP kinase pathway by calcium signaling and its involvement in neuronal diseases

Kohsuke Takeda, Hidenori Ichijo
Cell Signaling, Grad. Sch. Pharmaceut. Sci. , Univ. of Tokyo, CREST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 39-39, 2006.

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S2B2-1 Animal experiments recommended by Japanese Pharmacological Society (evaluation and decrease of pain) 1) Introduction

Yasuo Ohno
Nat. Inst. Health Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 40-40, 2006.

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S2B2-2 Pharmacology of pains

Masamichi Satoh
Nara Inst. Sci. Tech. , Ikoma, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 40-40, 2006.

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S2B2-3 Evaluation and standard of pain, distress, and euthanasia

Yukihisa Matsuda
Animal Research Laboratory, Bioscience Research-Education Center, Akita University, Akita, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 40-40, 2006.

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S2B2-4 Animal experiment ethics committee in Showa University

Norimitsu Kurata1, 2, Hajime Yasuhara1, 2
1Dept. Pharmacol. Sch. of Med. , Showa Univ. , Tokyo, Japan. ,, 2Showa University Ethics Committee for Animal Care and Use, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 40-40, 2006.

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S2B2-5 Research animal facility inspection by the third party

Tsutomu Kurosawa
The Institute of Experimental Animal Sciences, Osaka University Medical School, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 41-41, 2006.

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S2C2-1 Regulatory mechanisms of alternative splicing of viral RNA identified by reverse chemical genetics

Masatoshi Hagiwara
Sch. Biomed. Sci. , Tokyo Med. & Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 41-41, 2006.

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S2C2-2 Chemical biology on histone deacetylases

Minoru Yoshida1, Norikazu Nishino2
1Chem. Genet. Lab. , RIKEN, Saitama, Japan,, 2Grad. Sch. Life Sci. Sys. Eng. , Kyushu Inst. Technol. , Kitakyushu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 41-41, 2006.

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S2C2-3 Chemical probes which convert cellular biological events to chemical output

Kazuya Kikuchi
Grad. School Engineering, Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 41-41, 2006.

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S2C2-4 In vivo molecular science toward new biofunctions and drug discovery

Masaaki Suzuki
Gifu University Graduate School of Medicine, Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 42-42, 2006.

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S2C2-5 Molecular mechanistic insights into the intramembrane proteolysis by γ -secretase

Taisuke Tomita, Takeshi Iwatsubo
Dept. Neuropathol. Neurosci. , Grad. Sch. Pharm. Sci. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 42-42, 2006.

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S2C2-6 Development of chemical biology utilizing a screening system of affinity purification with nano size beads

Hiroshi Handa
Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 42-42, 2006.

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S2C2-7 Chemical biology of retinoids: their structures and functions

Hiroyuki Kagechika
School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 42-42, 2006.

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S2D2-1 ODN-based molecular therapy for vascular diseases

Motokuni Aoki1, 2, Ryuichi Morishita2
1Dept. Geriatric Medicine, Osaka Univ. Sch. Med. , Osaka, Japan,, 2Div. Clinical Gene Therapy Science, Osaka Univ. Sch. Med. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 43-43, 2006.

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S2D2-2 Self-regulatory system of angio-genesis in vascualr endothelium

Yasufumi Sato
Dept. Vasc. Biol. , IDAC, Tohoku Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 43-43, 2006.

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S2D2-3 Modulation of RLP-induced vascular inflammation during atherosclerosis

Masayuki Yoshida1, Mariko Tani1, Akio Kawakami2
1Dept. Vascular Medicine, Tokyo Med Dent Univ. , Tokyo, Japan,, 2Dept. Nutrition, Harvard School of Public Health, Boston MA
Journal of Pharmacological Sciences 100 (suppl.1) 43-43, 2006.

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S2D2-4 Roles of the prostanoids in the cardiovascular system

Koh-ichi Yuhki1, Jun-ichi Kawabe1, Osamu Takahata1, Akiyoshi Hara1, Shuh Narumiya2, Fumitaka Ushikubi1
1Dept. Pharmacol. , Asahikawa Med. Coll. , Asahikawa, Japan,, 2Dept. Pharmacol. , Fac. Med. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 43-43, 2006.

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S2D2-5 Roles of Na+/Ca2+ exchanger NCX1 in cardiovascular diseases

Takahiro Iwamoto
Dept. Pharmacol. , Sch. Med. , Fukuoka Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 44-44, 2006.

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S2D2-6 The essential role of membrane raft and its associated protein, Fyn, in Ca2+ sensitization of vascular smooth muscle contraction

Sei Kobayashi, Hiroko Kishi, Hozumi Kawamichi, Fengling Guo, Junying Miao, Katsuko Kajiya, Dan Xu
Dept. of Mol. Physiol. , Yamaguchi Univ. Sch. of Med. , Ube, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 44-44, 2006.

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S2C3-1 Role of Gα12/13 in the development of heart failure

Motohiro Nishida, Hitoshi Kurose
Dept. Pharmacol. & Toxicol. , Grad. Sch. Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 44-44, 2006.

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S2C3-2 Ligand identification and functional analysis for orphan GPCR GPR120

Akira Hirasawa, Gozoh Tsujimoto
Dept. Genomic Drug Discovery Sci. , Grad. Sch. Pharmaceu. Sci, Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 44-44, 2006.

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S2C3-3 Prostanoid receptors; Analyses of their functions by using the animal disease models

Toshiyuki Matsuoka, Shuh Narumiya
Dept. Pharmacol. , Kyoto Univ. Fac. Med. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 45-45, 2006.

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S2C3-4 Toward the development of new medicinal leads with selectivity for protein kinase C isozymes

Kazuhiro Irie
Div. Food Sci. & Biotechnol. , Grad. Sch. Agric. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 45-45, 2006.

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S2C3-5 Diacylglycerol kinase as a target of drugs for anti-diabetic renal dysfunction

Yasuhito Shirai, Naoaki Saito
Mol. Pharmacol. , Biosignal Res. Ctr. , Kobe Univ. , Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 45-45, 2006.

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S2D3-1 Nuclear IkB proteins regulate activity of innate immunity and intestinal inflammation

Kiyoshi Takeda
Dept. Mol. Genetics, Med. Inst. Bioreg. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 45-45, 2006.

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S2D3-2 TNF α directly suppresses smooth muscle contractility through CPI-17 down-regulation in intestinal inflammation

Masatoshi Hori, Hiroshi Ozaki
Dept. of Vet. Pharmacol. , Grad. Sch. of Agr. & Life Sci. , The Univ, of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 46-46, 2006.

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S2D3-3 Structure and function of cap-saicin receptor TRPV1, and its involvement in gastrointestinal hyperalgesia

Makoto Tominaga
Sec. Cell Signaling, Okazaki Inst. Integrative Biosci. , Okazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 46-46, 2006.

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S2D3-4 Physiology and pathophysiology of proteinase-activated receptors (PARs) in the gastrointestinal tract

Atsufumi Kawabata
Div. Physiol, Pathophysiol. , Sch. Pharmnaceut. Sci. , Kinki Univ. , Higashi-Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 46-46, 2006.

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S2D3-5 Increased gastrointestinal toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) in arthritic animals

Shinichi Kato, Koji Takeuchi
Dept. Pharmacol. Exp. Ther. Kyoto Pharm. Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 46-46, 2006.

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S2E1-1 The role of Semaphorin in axon guidance and dendritic growth and spine morphogenesis

Yoshio Goshima
Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. Sch. Med. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 47-47, 2006.

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S2E1-2 Dynamism and regulation of synaptic assembly in vivo

Akinao Nose, Hiroshi Kohsaka
Dept. Physics, Sch. Science, Tokyo Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 47-47, 2006.

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S2E1-3 mTOR-mediated mechanism of local activation of translation in dendrites: Its implication for neural plasticity

Nobuyuki Takei
Dept. Mol. Neurobiol. , Brain Res. Inst. Niigata Univ. , Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 47-47, 2006.

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S2E1-4 Dynamics of PSD molecules in glutamatergic synapses

Shigeo Okabe
Dept. Cell Biol. , Tokyo Med, Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 47-47, 2006.

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S2E1-5 Formation and dynamics of neural networks in the hippocampal formation

Yuji Ikegaya
Grad Sch Pharmaceut Sci, Univ Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 48-48, 2006.

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S3A1-1 PPAR γ ligand pioglitazone as a therapeutic strategy in nonalcoholic steato-hepatitis

Masato Yoneda1, Koji Fujita1, Atsushi Nakajima1, Koichiro Wada2
1Dept. Gastroenterol. , Yokohama City Univ. Sch. Med. , Yokohama, Japan,, 2Dept. Pharmacol. , Osaka Univ. Sch. Dent. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 48-48, 2006.

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S3A1-2 PPAR δ and metabolic syndrome

Toshiya Tanaka, Tatsuhiko Kodama
LSBM at RCAST, Univ. of Tokyo, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 48-48, 2006.

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S3A1-3 Decreased PPARs activity mediated inability of cell adhesion and invasion in colorectal carcinoma cells

Hirokazu Takahashi, Hitoshi Nakagama
National Cancer Center, Biochemistry Division, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 48-48, 2006.

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S3A1-4 K ATP channel-independent pathways involved in glucose-induced insulin secretion

Tomohisa Ishikawa, Koichi Nakayama
Dept. Cell Mol. Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Univ. Shizuoka, Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 49-49, 2006.

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S3A1-5 L-cysteine metabolism and hydrogen sulfide (H2S); a new signal pathway for inhibition of insulin release

Ichiro Niki, Yukiko Kaneko
Dept. Pharmacol. , Oita Univ. Faculty Med. , Oita, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 49-49, 2006.

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S3A1-6 Sox6 attenuates glucose stimulated insulin secretion by repressing pdx1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice

Juro Sakai1, 2
1Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, , Tokyo, Japan,, 2JST/ERATO, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 49-49, 2006.

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S3B1-1 Intractable progressive neural diseases; Recent studies and therapeutic strategies

Takeshi Suzuki
Dept. Basic Biol. Sci. , Kyoritsu Univ. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 49-49, 2006.

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S3B1-2 ALS research: Fruit and perspective

Shin Kwak1, Takeshi Suzuki2
1Dept. Neurol. , Grad Sch. Med. , Univ. Tokyo, Tokyo, Japan,, 2Dept. Basic. Biol. Sci. , Kyoritsu Univ. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 50-50, 2006.

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S3B1-3 Multiple sclerosis: Pathogenesis and therapeutic strategy

Takashi Yamamura, Jun-ichi Satoh, Sachiko Miyake
Dept. Immunol. , Nat Instit Neurosc. , NCNP, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 50-50, 2006.

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S3B1-4 Molecular targeted therapy for polyglutamine disease with special reference to SBMA

Gen Sobue
Dept. Neurol. , Nagoya Univ. Grad. Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 50-50, 2006.

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S3B1-5 Progress in the research and neurotherapeutics for Parkinson's disease

Nobutaka Hattori
Dept. Neurol. , Juntendo Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 50-50, 2006.

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S3B1-6 Metabolism of amyloid-β peptide and Alzheimer's disease

Nobuhisa Iwata, Takaomi C. Saido
Lab. for Proteolytic Neurosci. , RIKEN BSI, Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 51-51, 2006.

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S3C1-1 Cyclic ADPR as a second messenger in peptide signal transduction

Haruhiro Higashida
Dept. Biophy. Genetics, Kanazawa U. Grad. Sch. Med. , Kanazawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 51-51, 2006.

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S3C1-2 Roles of calcitonin gene related peptide in maintenance of gastric mucosal integrity and healing process of ulcer

Takashi Ohno1, 2, 3, Masataka Majima1
1Dept. Pharmacol. , Kitasato Univ. Sch. Med. , Kangawa, Japan,, 2Dept. Internal Med. , Kitasato Univ. Sch. Med. , Kanagawa, Japan,, 3Dept. Internal Med. , Isehara Kyodo Hospital, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 51-51, 2006.

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S3C1-3 Central feeding regulation by using mice lacking for NPY receptor sub-classes

Hiroshi Higuchi, Takeshi Niki, Tomohiro Shiiya, Kumiko Kagawa
Div. Pharmacol. , Niigata Univ. Grad. Sch. Med. Dent. Sci. , Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 51-51, 2006.

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S3C1-4 Role of insulin signalings as a modulator of neurogenesis and neuroprotection: Regulatory mechanism of Na+ channel expression by insulin

Toshihiko Yanagita, Hiroki Yokoo, Takayuki Nemoto, Shinya Satoh, Hideyuki Kobayashi, Akihiko Wada
Dept. Pharmacol. , Miyazaki Med. Coll. , Univ. Miyazaki, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 52-52, 2006.

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S3C1-5 Cardioprotective effects of kallikrein-kinin system

Hideaki Yoshida, Nobuyuki Ura, Kazuaki Shimamoto
Second Dept. of Internal Medicine, Sapporo Medical Univ. Sch. Med. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 52-52, 2006.

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S3D1-1 Human sleep disorders and clock genes

Takashi Ebisawa
Dept. Sleep Disord. Res. , Grad. Sch. Med. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 52-52, 2006.

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S3D1-2 Chronopharmacological findings of antitumor drugs

Shigehiro Ohdo
Pharmaceutics, Div. Clin. Pharmacy, Dept. Medico-Pharm. Sci. , Fact. Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 52-52, 2006.

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S3D1-3 Role of biological clock in cardiovascular diseases

Koji Maemura
Dept. Cardiovasc. Med, Grad. Sch. Med. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 53-53, 2006.

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S3D1-4 Bronchial asthma and the function of human clock genes

Naoto Burioka
Medical Oncology and Molecular Respirology, Faculty of Medicine, Tottori Univ, Yonago, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 53-53, 2006.

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S3D1-5 Role of circadian clock on hyperc-holesterolemia, obesity and diabetes

Shigenobu Shibata
Dept. Pharmacology, School of Science and Engineering, Waseda University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 53-53, 2006.

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S3A2-1 Pharmacogenomics in drug metabolizing enzymes

Ichiro Ieiri
Dept. Pharmacy, Tottori Univ. Hospital, Yonago, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 53-53, 2006.

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S3A2-2 Interindividual variability of drug transporters

Yuichi Sugiyama
Graduate School of Pharmaceutical Sciences, the Univ. of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 54-54, 2006.

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S3A2-3 Pharmacogenomics for pharma-codynamics, analysis of the inter-individual variability

Junichi Azuma
Graduate School of Pharmaceutical Sciences, Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 54-54, 2006.

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S3A2-4 Individual differences based on adverse effects-related genes : Genomic analyses in clinical and non-clinical studies

Sunao Manabe
Med. Saf. Res. Labs. , Sankyo Co. , Ltd. , Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 54-54, 2006.

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S3A2-5 Use of animal models for genomic drug discovery

Gozoh Tsujimoto
Dept. Genomic Drug Discovery Sci. , Kyoto Univ. Pharm. Sci. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 54-54, 2006.

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S3A2-6 Comparative pharmacogenomics of human disease model animal

Toshio Tanaka1, 2
1Dept. Pharmacogenomics, Mie Univ. Gra Sch. Med. , Tsu Mie , Japan,, 2Bioinfo Mie Univ. Life Science RC, Tsu Mie, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 55-55, 2006.

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S3B2-1 Translational control of γ -secre-tase activity, augmenting amyloid-β production

Toshiyuki Nakagawa
Dept. Neurobio. , Gifu Univ. Grad. Sch. Med. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 55-55, 2006.

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S3B2-2 Endoplasmic reticulum (ER) stress and ischemic neuronal cell death

Hideaki Hara
Dept. Biofunctional Molecules, Gifu Pharmaceutical Uni. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 55-55, 2006.

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S3B2-3 Regulation of glutamate neurotoxicity by serofendic acid, a low molecular weight neuroprotective substance

Akinori Akaike, Hiroshi Katsuki, Toshiaki Kume
Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 55-55, 2006.

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S3B2-4 Nobiletin, a citrus flavonoid activating a PKA/ERK/CREB-dependent signaling pathway, rescues Aβ -induced memory impairment in Alzheimer's disease animal model

Tohru Yamakuni1, Akira Nakajima1, Michio Hashimoto2, Osamu Shido2, Akihito Yokosuka3, Yutaka Sashida3, Yoshihiro Mimaki3, Yasushi Ohizumi1
1Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan,, 2Department of Environmental Physiology, Shimane University, School of Medicine, Shimane, Japan,, 3Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 56-56, 2006.

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S3B2-5 Effects of Chotosan to related vascular dementia

Takahiro Shintani, Eiichi Tahara
Research Institute of Oriental Medicine, Kinki Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 56-56, 2006.

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S3B2-6 Current progress in the diagnosis and treatment of dementia

Hiroyuki Arai
Dept. Geriatr & Complement. Tohoku Univ. Sch. Med. , Miyagi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 56-56, 2006.

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S3C2-1 Dysfunction of AQP5 in parotid of diabetes

Yasuko Ishikawa1, Gota Cho2, Noriko Inoue1, Yan Pan3, Yoshiko Nakae4
1Dept. Medical Pharmacol. , Univ, of Tokushima Graduate School, Tokushima, Japan,, 2Dept. of Dental Anesthesiology, Univ. of Tokushima Graduate School, Tokushima, Japan,, 3Dept. of Pharmacol. Peking Univ. , Beijing, China,, 4Dept. of Anatomy, Univ. of Tokushima Graduate School, Tokushima, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 56-56, 2006.

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S3C2-2 Diabetic stress and protective function in salivary gland

Masahito Watanabe1, Masatake Izumi2, Mitsuru Kawaguchi1, Hisako Wang1, Migiwa Okubo1
1Dept. Pharmacol. , Tokyo Dent. Coll. , Chiba, Japan,, 2Dept. Orthodont. , Tokyo Dent. Coll. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 57-57, 2006.

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S3C2-3 Drug excretion in salivary glands: Clinical pharmacokinetic application and involvement of transporters

Hiroaki Yuasa, Yayoi Hayashi
Dept. Biopharm. , Nagoya City Univ. Sch. Pharm. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 57-57, 2006.

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S3C2-4 Electrolyte transport and evaluation of secretory function in salivary glands

Chikara Hirono
Dept. Oral Physiol. , Hiroshima Univ. Grad. Sch. Biomed. Sci. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 57-57, 2006.

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S3C2-5 Marker protein of salivary glands and functional diagnosis

Mitsuru Kawaguchi1, Takashi Shinomiya1, Masanobu Yoshikawa2, Yasuhiro Kosuge1
1Dept. Pharmacol. , Tokyo Dent. Coll. , Chiba, Japan,, 2Dept. Pharmacol. , Tokai Univ. Sch. Med. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 57-57, 2006.

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S3D2-1 Molecular imaging of free radical reactions in small animals using Overhauser-enhanced MRI and ESRI

Hideo Utsumi
Dept. Bio-function Sci. Fac. Pharmaceu. Sci. Kyushu Uni. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 58-58, 2006.

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S3D2-2 Molecular imaging of drug targets

Tetsuya Suhara
Molecular Imaging Center, Nat. Inst. Radiological Sciences, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 58-58, 2006.

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S3D2-3 Development of PET probes for in vivo amyloid imaging and its clinical application

Nobuyuki Okamura1, Kazuhiko Yanai1, Yukitsuka Kudo2
1Dept. Pharmacol. , Tohoku Univ. Sch. Med. , Sendai, Japan,, 2TUBERO, Tohoku Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 58-58, 2006.

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S3D2-4 Molecular imaging studies in rodents with PET

B. Robert Innis
Molecular Imaging Branch, National Institute of Mental Health (NIMH), Bethesda, MD, USA
Journal of Pharmacological Sciences 100 (suppl.1) 58-58, 2006.

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O1E1-1 Early postnatal stress alters the serotonergic function underlying regulation of emotional stress at postadolescent periods of rats

Kohtaro Konno1, Machiko Matsumoto1, Taku Yamaguchi1, Hiroko Togashi2, Toshihiko Iwanaga3, Mitsuhiro Yoshioka1
1Dept. Neuropharmacology, Grad. Sch. Med. , Hokkaido Univ. , Sapporo, Japan,, 2Dept, Clin Physiol, Facul. Pharm. Sci. , Hokkaido Hlth. Sci. Univ. , Hokkaido, Japan,, 3Dept. Histology and Cytology, Grad. Sch. Med. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 60-60, 2006.

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O1E1-2 Effect of Ginkgo biloba extracts on activation of ERK/MAP kinase in the rat hypothalamus after forced swimming test

Hiroyuki Sakakibara1, Yuki Izawa2, Yuko Minami1, Satomi Saito1, Yoshichika Kawai1, Veronika Butterweck3, Toshiaki Tamaki2, Junji Terao1
1Dept. Food Sci. , Inst. HBS, Univ. of Tokushima Grad. Sch. , Tokushima, Japan,, 2Dept. Pharmacol. , Inst. HBS, Univ. of Tokushima Grad. Sch. , Tokushima, Japan,, 3Dept. Pharmaceutics, Univ. of Florida, University of Florida, USA
Journal of Pharmacological Sciences 100 (suppl.1) 60-60, 2006.

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O1E1-3 Possible involvement of the cortical GABAergic system in hippocampal synaptic responses in juvenile stress model of rats

Hiroyo Koseki1, Machiko Matsumoto2, Hiroko Togashi3, Riki Hirata2, Taku Yamaguchi2, Kazuaki Fukushima1, Mitsuhiro Yoshioka2
1Dept. Oral Pathobiological Science. , Hokkaido Univ. , Graduate Sch. Dent. Med. , Sapporo, Japan,, 2Dept. Neuropharmacol. , Hokkaido Univ. , Graduate Sch. Med. , Sapporo, Japan,, 3Dept, Clin Physiol. , Facul. Pharm. Sci. , Hokkaido Hlth. Sci. Univ. , Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 60-60, 2006.

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O1E1-4 Effects of diabetes on freezing behavior and 5-HT release in the mPFCx under stressful condition in mice

Shigeo Miyata, Naoko Yamada, Shoko Hirano, Junzo Kamei
Dept. of Pathophysiol. and Therap. , Sch, of Pharm. and Pharm, Sci, Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 60-60, 2006.

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O1E1-5 5-HT7 receptors play a critical role in fear conditioning in mice: possible involvement of amygdaloid ERK pathway

Minoru Tsuji1, Hiroshi Takeda1, Kaneaki Matsushita2, Masashi Tahara2, Makio Iimori2, Teruhiko Matsumiya1
1Dept. Pharmacol., Tokyo Med. Univ., Tokyo, Japan, 2Dept. Psychiat., Tokyo Med. Univ., Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 61-61, 2006.

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O1F1-1 Balloon injury up-regulates the expression of proteinase-activated receptors and induces vasospasm at the injury site in rabbit femoral artery

Ryota Fukunaga, Katsuya Hirano, Mayumi Hirano, Naohisa Niiro, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol. , Res. Inst. Angiocardiol. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 61-61, 2006.

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O1F1-2 Pharmacological properties of T-7461 , a new dual AT1 receptor and L-type calcium channel blocker

Shuichi Harada, Minako Kaburaki, Yaeko Koyama, Kouhei Kikkawa, Hiroshi Narita, Makoto Katoh
Pharmacology Research Laboratories, Tanabe Seiyaku, Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 61-61, 2006.

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O1F1-3 Differential contribution of Rho-kinase and protein kinase C isoforms to pressure-induced myogenic constriction in rat posterior cerebral arteries

Toshihide Kashihara
Dept. Cell. Mol. Pharmacol. , Grad. Sch. Phrmaceut. Sci. , Univ. Shizuoka, Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 61-61, 2006.

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O1F1-4 Mechanisms underlying the impaired EDHF-type relaxation in mesenteric arteries from diabetic rats

Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept. Physiol, and Morphol. , Inst. Med. Chem. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 62-62, 2006.

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O1F1-5 Relaxin relaxes rat myometrium by decreasing Ca2+ sensitivity of contractile apparatus via a cAMP/PKA signaling pathway

Masahide Miyazaki, Naohisa Niiro, Katsuya Hirano, Mayumi Hirano, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol. , Res. Inst. Angiocardiol. , Grad. Sch. Med. Sci. , Kyushu. Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 62-62, 2006.

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O1G1-1 Role of membrane phospholipids in the intracellular trafficking of CFTR

Yasuaki Hashimoto1, Tsukasa Okiyoneda1, Kazutsune Harada1, Keiko Ueno1, Takuya Sugahara1, Atsushi Yamashita2, Tsuyoshi Shuto1, MaryAnn Suico1, Hirofumi Kai1
1Dept. Mol. Med. , Fac. Med. Pharm. , Kumamoto Univ. , Kumamoto, Japan,, 2Dept. Mol. Health. Sci. , Fac. Pharm. Sci. , Teikyo Univ. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 62-62, 2006.

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O1G1-2 Investigation of mechanisms mediated by PPAR γ -inhibition on anti-tumor effect in various carcinoma cell lines

Tomotake Masuda1, 2, Koichiro Wada1, Atsushi Nakajima3, Masaya Okura2, Mikihiko Kogo2, Yoshinori Kamisaki1
1Dept. Pharmacol. , Grad. Sch. Dent. , Osaka Univ, Suita, Japan,, 2Dept. Oral and Maxillofacial Surg one. , Grad. Sch. Dent. , Osaka Univ, Suita, Japan,, 3The Third Dept, Internal Med. , Yokohama City Univ. Sch. Med. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 62-62, 2006.

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O1G1-3 Lipid metabolism of ICR background Clock mutant mouse under high fat diet

Takashi Kudo, Mihoko Kawashima, Toru Tamagawa, Shigenobu Shibata
Dept. Pharmacol. , Waseda Univ. Sch. Science and Engineering, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 63-63, 2006.

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O1G1-4 Regulation of insulin receptor substrate-2 expression by calcineurin activity

Shinya Satoh, Toshihiko Yanagita, Norie Yoshikawa, Toyoaki Maruta, Takayuki Nemoto, Hiroki Yokoo, Hideyuki Kobayashi, Akihiko Wada
Dept. Pharmacol. , Miyazaki Med. Coll. , Univ. Miyazaki, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 63-63, 2006.

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O1G1-5 The enhancement of chemotherapy sensitivity by cathepsin E

Tomoyo Kawakubo, Takayuki Tsukuba, Kenji Yamamoto
Dept. Pharmacol. , Grad. Sch. of Dent. Sci. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 63-63, 2006.

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O1H1-1 Behavioral pharmacology of plant-derived substances (15): Effects of menthol on extracellular dopamine, seroto-nine, norepinephrine and their metabolites in mouse striatum. Comparison with effects of bupropion, methylphenidate and caffeine.

Toyoshi Umezu
Endocrine Disruptors and Dioxin Project, Natl. Inst. Environ. Studies, Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 63-63, 2006.

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O1H1-2 A possible involvement of non-enzymatic metabolites of DOPA in DOPAergic responses

Tatsurou Yagami1, Reina Aoki1, Yoshinobu Sugiyama1, Yasuhiro Kajihara2, Naoki Yamamoto2, Yoshio Goshima1
1Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. Grad. Sch. Med. , Yokohama, Japan,, 2Dept. System Function, Yokohama City Univ. Grad. Sch. Integ. Sci. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 64-64, 2006.

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O1H1-3 Tyrosine hydroxylase in dopaminergic nerve terminals projecting to the lateral region of the striatum is the most sensitive to tetrahydrobiopterin-insufficiency

Chiho Sumi-Ichinose1, Fumi Urano2, Atsushi Shimomura3, Takashi Sato2, Kazuhisa Ikemoto1, Hiroaki Shiraishi1, Takao Senda3, Hiroshi Ichinose2, Takahide Nomura1
1Dept. Pharmacol. , Sch. Med. , Fujita Health Univ. , Aichi, Japan,, 2Dep. Life Sci. , Grad. Sch. Biosci. Biotech. , Tokyo Inst. Tech. , Kanagawa, Japan,, 3Dep. Anatomy I, Sch. Med. , Fujita Health Univ. , Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 64-64, 2006.

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O1H1-4 Effects of repeated administration of rotenone and MPTP on CNS dopaminergic system in mice

Ryoichi Kawamoto1, Haruo Kobayashi2, Muhammad. M. Hossain3, Tadahiko Suzuki2, Itaru Sato2
1Animal Quarant. , Minist. Agric. , Yokohama, Japan,, 2Dept. Vet. Med. , Iwate Univ. , Fac. Agric. , Morioka, Japan,, 3Dept. Pharmacol. , Iwate Med. Univ. , Sch. Med. , Morioka
Journal of Pharmacological Sciences 100 (suppl.1) 64-64, 2006.

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O1H1-5 Deprenyl protected neural damage partially but showed marked attenuation of parkinsonism in MPTP-treated common marmosets

Kiyoshi Ando1, 2, Motoki Inaji2, Jun Maeda2, Eisuke Haneda2, Makoto Higuchi2, Tetsuya Suhara2, Hajime Ishii1, Yoshikuni Tanioka1
1Neurobehav Res Proj. , Cent Inst Lab Anim, Kawasaki, Japan,, 2Molec Imaging Center, Nat Inst Radiol Sci, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 64-64, 2006.

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O1J1-1 Osteopontin has a prominent role in the intracellular signaling in osteoclast migration and fusion

Keiko Suzuki1, Jaro Sodek2, Shoji Yamada1
1Dept. Pharmacol. , Sch. Dent. , Showa Univ. , Tokyo, Japan,, 2CIHR Group in Matrix Dynamics, Fac. Dent. , Univ. of Toronto, Canada
Journal of Pharmacological Sciences 100 (suppl.1) 65-65, 2006.

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O1J1-2 Involvement of glycosphingolipids in LPS mediated survival of mature osteo-clasts

Eiko Sakai1, Satoshi Fukumoto2, Kazuhisa Nishishita1, Jinping Hu1, Kuniaki Okamoto1, Yuzo Kato1
1Dept. Develop. Reconstruct. Med. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 2Dept. Oral Health, Growth and Develop. , Kyushu Univ. Grad. Sch. Dent. Sci. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 65-65, 2006.

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O1J1-3 Changes in bone density and met-allothionein mRNA expression in the tibiae of ovariectomized rats

Norio Sogawa, Chiharu Sogawa, Kenji Onodera, Shigeo Kitayama
Dept. Pharmacol. , Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 65-65, 2006.

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O1J1-4 Effect of PDGF on restoration of the support function of healing periodontal ligament in replanted rat teeth

Koichiro Komatsu1, Tatsuya Shibata1, Akemi Shimada1, Shinnji Shimoda2, Shinichiro Oida3, Kenzo Kwasaki2
Anatomy I, Tsurumi Univ. Sch. Dent. , Yokohama, Japan, 3Dept. Biochem. , Tsurumi Univ. Sch. Dent. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 65-65, 2006.

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O1J1-5 18α-glycyrrhetinic acid inhibits the growth of nifedipine responder cell

Reiri Takeuchi1, Hiroko Matsumoto1, Yoshiaki Akimoto2, Mami Hori1, Akira Fujii1
1Dept. Oral Mol. Pharmacol. , Nihon Univ. Sch. Dent. Chiba, Japan,, 2Dept. Oral surg. , Nihon Univ. Sch. Dent. Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 66-66, 2006.

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O1E2-1 Supraspinal pituitary adenylate cyclase-activating polypeptide (PACAP) exhibits antinociception mediated by the noradrenergic neurons in the central nervous system

Hikaru Sakamoto1, Takao Shimizu2, Tetsuya Onou3, Mikiko Higashi3, Shin-ichi Iwata2, Setsuro Komiya1, Atsuro Miyata2
1Dept. Orthop. Surg. , Kagoshima Univ. Grad. Sch. Med. Dent. Sci. , Kagoshima, Japan,, 2Dept . Pharmacol. , Kagoshima, Japan,, 3Dept. Anesthsiol. , Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 66-66, 2006.

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O1E2-2 Possible mechanisms of induction and maintenance of intrathecal ATP-elicited long-lasting allodynia in rats

Kayo Wakamatsu1, Takayuki Nakagawa1, Sanae Maeda1, Nannan Zhang1, Masamichi Satoh2, Shuji Kaneko1
1Dept. Mol. Pharmacol. , Grad. Sch. Pharmaceu. Sci. , Kyoto Univ. , Kyoto, Japan,, 2Nara Inst. Sci. & Tech. , Ikoma, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 66-66, 2006.

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O1E2-3 Modulation of nociceptive transmission by mevalonate in the mouse spinal cord

Masahiro Ohsawa, Junpei Mutoh, Hiroaki Hisa
Second Dept. Pharmacol. , Kyushu University Health and Welfare, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 66-66, 2006.

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O1E2-4 Activation of cytosolic phospholi-pase A2 in sensory neurons of a neuropathic pain model

Shigeo Hasegawa, Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 67-67, 2006.

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O1E2-5 The role of ATP receptor subtypes on the painful diabetic neuropathy in mice

Chihiro Nozaki, Junzo Kamei
Dept. Pathophysiol. Ther. , Sch. Pharm. Pharm. Sci. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 67-67, 2006.

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O1F2-1 Differential mechanisms of bradykinin-induced vasodilation in retinal and peripheral blood vessels of rats

Naoki Kojima, Maki Saito, Asami Mori, Tsutomu Nakahara, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol. , Kitasato Univ. Sch. Pharm. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 67-67, 2006.

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O1F2-2 Transplantation of angiotensin type 1a knock out bone marrow cells inhibit tumor-associated angiogenesis and tumor growth

Mamoru Fujita1, Atsuhiko Oikawa2, Akiyoshi Fukamizu3, Moritoshi Itoman1, Masataka Majima2
1Dept. Orthop. Surg. , Kitasato Univ. Sch. Med. , Kanagawa, Japan,, 2Dept. Phamacol. , Kitasato Univ. Sch. Med. , Kanagawa, Japan,, 3Center for Tsukuba Advanced Research Alliance, Institute of Applied Biochem. , Tsukuba Univ. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 67-67, 2006.

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O1F2-3 Recruitment of a prostaglandin E receptor subtype, EP3-expressing bone marrow cells is crucial in wound healing and angiogenesis

Emi Kamoshita1, 2, Yasuhiro Ikeda1, 2, Mamoru Fujita1, Atsuhiko Okikawa1, Nobuya Unno2, Shu Narumiya3, Masataka Majima1
1Dept. Pharmacol. , Kitasato Univ. Sch. Med. , Kanagawa, Japan,, 2Dept. of Obstetrics Gynecology, Kitasato Univ. Sch. Med. , Kanagawa, Japan,, 3Dept. Pharmacol. , Kyoto Univ. Sch. Med. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 68-68, 2006.

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O1F2-4 M-1, a major metabolite of sar-pogrelate, has an inhibitory effect on not only 5-hydroxytryptamine (5-HT)2a but also 5-HT1B receptors-mediated vasoconstriction in isolated human radial artery and saphenous vein

Naoko Tanaka1, Masamichi Ohkura1, Eisaku Nakamura2, Masachika Kuwabara2, Yujiro Asada3, Hiroaki Hisa4, Ryuichi Yamamoto1
1First Dept. Pharmacol. , Sch. Pharmaceut. Sci. , Kyusyu Univ. Hlth. Welfare, Miyazaki, Japan,, 2Dept. Cardiovasc. Surg. Miyazaki Pref. Nobeoka Hosp. , Miyazaki, Japan,, 3First Dept. Pathol. , Miyazaki Med. Coll. , Univ. , Miyazaki, Japan,, 4Second Dept. Pharmacol. , Sch. Pharmaceut. Sci. , Kyusyu Univ. Hlth. Welfare, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 68-68, 2006.

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O1F2-5 Difference in mechanisms of 5-hydroxytryptamine- and U46619-induced vasoconstrictions

Katsunari Tasaki1, Masatoshi Hori2, Hiroshi Ozaki2, Hideaki Karaki2, Ichiro Wakabayashi3
1Dept. LIfe Studies, Gifu Shotoku Gakuen Univ. Junior Coll. , Gifu, Japan,, 2Dept. Vet. Pharmacol. , Grad. Sch. of Agri. and Life. Sci. , The Univ. of Tokyo, Tokyo, Japan,, 3Dept. Hygiene and Preventive Med. , Yamagata Univ. Sch. of Med. , Yamagata, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 68-68, 2006.

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O1G2-1 Regulational analysis and its signalling pathway of the mouse gicerin gene

Keiko Kohama, Eiichi Taira
Dept. Pharmacol. , Iwate Medical Univ. , Iwate, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 68-68, 2006.

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O1G2-2 Involvement of endoplasmic reticulum stress in neuronal death after transient forebrain ischemia in gerbils

Yasuhisa Oida, Masamitsu Shimazawa, Hideaki Hara
Dept. Biofunctional Molecules, Gifu Pharmaceutical Univ. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 69-69, 2006.

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O1G2-3 Ketamine inhibits desensitization of GABAB receptor-mediated signaling through interaction with GRK4

Masato Kanaide1, 2, Yasuhito Uezono2, Minoru Hojo1, Masanori Matsumoto1, Yasuhiro Yoshida2, Koji Sumikawa1, Kohtaro Taniyama2
1Dept. Anesthesiol. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 2Dept. Pharmacol. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 69-69, 2006.

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O1G2-4 Physiological increase in extracellular calcium concentration evokes an increase in cytoplasmic calcium concentration via L-type calcium channels in human hyperparathyroid cells

Douchi Matsuba1, Akifumi Suzuki2, Toshiaki Shibasaki2, Rinako Iida3, Keitaro Yokoyama3, Hiroshi Takeyama4, Mitsuyoshi Urashima5, Norio Suda1
1Dept. Physiol. , Jikei Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Pharmacotherapeutics, Kyoritsu Univ. Pharmacy, Tokyo, Japan,, 3Dept. Nephrol. & Hypertension, Jikei Univ. Sch. Med. , Tokyo, Japan,, 4Dept. Surgery, Jikei Univ. Sch. Med. , Tokyo, Japan,, 5Dept. Clin. Res. Development, Jikei Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 69-69, 2006.

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O1G2-5 Analysis of the target gene encoding in zebrafish S100A1 for heart disease

Yutaka Tamaru1, 3, Takeshi Wakasa1, Yoko Iwata1, Toshio Tanaka2, 3
1Fac. Bioresour. , Mie Univ. , Mie, Japan,, 2Grad. Sch. Med. , Mie, Japan,, 3Mie Univ. Life Science Res. Cen. , Mie, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 69-69, 2006.

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O1H2-1 Studies on drug dependence (Rept. 419): Role of orexin neuron located in ventral tegmental area in the morphine-induced rewarding effect

Yasuyuki Nagumo, Minoru Narita, Yoshinori Yajima, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 70-70, 2006.

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O1H2-2 Study of neuropathic pain mechanisms I - preemptive analgesia by morphine

Misaki Matsumoto, Makoto Inoue, Md Harunor Rashid, Hiroshi Ueda
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Journal of Pharmacological Sciences 100 (suppl.1) 70-70, 2006.

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O1H2-3 Studies on pain control system (Rept. 51): Chronic pain-induced emotional dysfunction is associated with cortical δ -opioid receptor dysfunction-dependent astrogliosis

Naoko Kuzumaki, Minoru Narita, Michiko Narita, Mayumi Miyatake, Nana Hareyama, Yoshinori Yajima, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 70-70, 2006.

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O1H2-4 The chronic morphine treatment increases the contents of D-serine in rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase

Masanobu Yoshikawa1, Atsushi Hashimoto1, Hiroyuki Kobayashi1, Mitsuru Kawaguchi2, Tetsuo Oka1
1Dep. Pharmacol. , Tokai Univ. Sch. Med, Kanagawa, Japan,, 2Dept. Pharmacol. , Tokyo Dental College, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 70-70, 2006.

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O1H2-5 Involvement of the endogenous opioid peptide on the antinociception induced by endomorphin-2 in the mouse spinal site

Hiroyuki Watanabe1, Wataru Sakurada1, Hirokazu Mizoguchi1, Chizuko Watanabe1, Tsutomu Fujimura2, Tsukasa Sakurada3, Shinobu Sakurada1
1Dept. Physiol. Anat. , Tohoku Pharmaceut. Univ. , Sendai, Japan,, 2Div. Biochem. Anal. , Ctr. Lab. Med. Sci. , Juntendo Univ. School Med. , Tokyo, Japan,, 3Dept. Biochem. , Daiichi Coll. Pharmaceut. Sci. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 71-71, 2006.

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O1J2-1 Development of novel tooth bleaching agent using electron spin resonance (ESR) spectroscopy

Fumihiko Yoshino, Yojito Maehata, Hirofumi Shoji, Shun-suke Takahashi, Kazuo Todoki, Masaichi-Chang-il Lee
Division of Pharmacology, Dept. Clinical Care Medicine, Kanagawa Dental College, Yokosuka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 71-71, 2006.

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O1J2-2 Nitrogen-containg bisphosphonate, YM529 inhibits RANKL expression in bone marrow stromal cell line ST2

Chisato Kato1, Masanobu Tsubaki1, Mayumi Hoshino1, Ayumi Namimatsu2, Hiromi Uji1, Masashi Yanae1, Shozo Nishida1
1Dept, of Pharmacotherapy, Kinki Univ. Sch. of Pharmaceutical Sci. , Japan,, 2Kinki Univ. Attachment Hospital, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 71-71, 2006.

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O1J2-3 The role of cathepsin E in tumor progression

Masashi Shin, Tomoko Kadowaki, Tomoyo Kawakubo, Takayuki Tsukuba, Kenji Yamamoto
Dept. Pharmacol. , Grad. Sch. Dent. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 71-71, 2006.

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O1J2-4 Application of software to simulate pharmacokinetics in practical training of pharmacology for undergraduate dental students

Tatsuya Shibata, Akira Yamane, Akemi Shimada, Junji Nagata, Koichiro Komatsu
Dept. Pharmacol. , Sch. Dent. Med. , Tsurumi Univ. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 72-72, 2006.

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O1E3-1 Imaging of extracellular glutamate dynamics in brain slices

Hiroshi Sekiya1, Yohei Okubo1, Shigeyuki Namiki2, Hirokazu Sakamoto2, Kenzou Hirose1, 2, Masamitsu Iino1
1Dept. Pharmacol. , Univ. Tokyo Sch. Med. , Tokyo, Japan,, 2Dept. Cell Physiol. , Nagoya Univ. Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 72-72, 2006.

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O1E3-2 Role of 5-HT1A receptors in fluvoxamine-induced suppression of marble-burying behavior in mice

Toshiya Harasawa1, Yukio Ago2, Soichi Itoh1, Akemichi Baba2, Toshio Matsuda1
1Lab. of Medicinal Pharmacol. Grad. Sch. of Pharmceut. Sci. , Osaka Univ. , Osaka, Japan,, 2Lab. of Mol. Neuropharmacol. , Grad. Sch. of Pharmceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 72-72, 2006.

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O1E3-3 Foxy Methoxy, N,N-diisopropyl-5-methoxytryptamine, a selective inhibitor of serotonin transporter

Chiharu Sogawa1, Norio Sogawa1, Kazumi Ohyama2, Junpei Tagawa3, Atsuko Fujino3, Masato Asanuma4, Masahiko Funada5, Kenji Onodera1, Shigeo Kitayama1
1Dept. Dent. Pharmacol. , Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. , Okayama, Japan,, 2RI Res. Cent. , Okayama Univ. Dent. Sch. , Okayama, Japan,, 3Okayama. Univ. Dent. Sch. , Okayama, Japan,, 4Dept. Brain. Set. , Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. , Okayama, Japan,, 5Dev. Drug Depend. , Narl. Cent. Neurol. Psychiat. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 72-72, 2006.

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O1E3-4 Muscarinic agonists enhance DNA synthesis via endoplasmic Ml receptor

Abu Syed Md Anisuzzaman, Shigeru Morishima, Fumiko Suzuki, Hatsumi Yamamoto, Takashi Tanaka, Ikunobu Muramatsu
Div. Pharmacol. , Dept. Biochemistry and Bioinformative Sciences, Fukui Univ. Sch. Med. , Fukui, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 73-73, 2006.

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O1E3-5 Metabotropic glutamate receptor-mediated postsynaptic inositol 1,4,5-trispho-sphate signaling is required for the maintenance of presynaptic function of parallel fiber-Purkinje cell synapses

Kazuharu Furutani, Yohei Okubo, Sho Kakizawa, Masamitsu Iino
Dept. Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 73-73, 2006.

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O1F3-1 High glucose-induced enhance-ment of endothelial cell permeability is involved in an increase of endothelial cell contraction

Mari Miyatake, Koji Nobe, Kazuo Honda
Dept. Pharmacol. , Showa Univ. Sch. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 73-73, 2006.

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O1F3-2 Leukemia inhibitory factor induces endothelial differentiation in cardiac Sca-1 + stem cells

Tomomi Mohri, Yasushi Fujio, Makiko Maeda, Takashi Ito, Tomohiko Iwakura, Yuichi Oshima, Yoriko Uozumi, Yasuhiro Yamamoto, Junichi Azuma
Dept. Clin. Evaluat. of Med. and Therapeut. , Grad. Sch, of Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 73-73, 2006.

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O1F3-3 Organization of cultured smooth muscle cells into vessel-like structure by endothelium-derived factor(s)

Masahiro Oike, Shuhei Konishi, Yushi Ito
Dept. Pharmacol. , Grad. Sch. Med. Sci. , Kyushu Univ, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 74-74, 2006.

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O1F3-4 Mechanisms underlying enhanced vasodilator responses to various vasodilator agents following endothelium removal in rat mesenteric resistance arteries

Yukiko Iwatani1, Hiromi Numa1, Saori Atagi1, Husako Takayama1, Mitunobu Mio2, Hiromu Kawasaki1
1Dept. Clin. Pharmac. Sci. , Grad. Sch. Med. Den. Pharmac. Sci. , Okayama Univ. , Okayama, Japan,, 2Dept. Clin. Pharm. Sch. Pharm. , Shujitsu Univ. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 74-74, 2006.

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O1F3-5 Eplerenone, a selective mineralo-corticoid receptor antagonist, inhibits cyclic stretch-induced NADPH activation through Nox1 in rat aortic smooth muscle cells

Yoshikazu Miwa, Takahiro Ohmine, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. , Fac. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 74-74, 2006.

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O1G3-1 Engineering of ligand-binding domain of the FRET-based prove LIBRA for tuning affinity for inositol 1,4,5-trisphosphate

Akihiko Tanimura, Takao Morita, Akiko Shitara, Akihiro Nezu, Yosuke Tojyo
Dept. Dent. Pharmacol. , Health Sci. Univ. Hokkaido Sch. Dent. , Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 74-74, 2006.

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O1G3-2 Different Ca2+ dependence of CICR activity in ventricular and atrial muscles from swine

Akihito Chugun1, Nagomi Kurebayashi1, Takashi Murayama1, Hiroto Nishizawa2, Kan Kajimoto3, Takatoshi Kasai2, Yasuo Ogawa1
1Dept. Pharmacol. , Juntendo Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Cardiology, Juntendo Univ. Sch. Med. , Tokyo, Japan,, 3Dept. Cardiovas. Surgery, Juntendo Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 75-75, 2006.

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O1G3-3 Involvement of inositol 1,4,5-trisphosphate signaling in glucose-induced Ca2+ responses in INS-1 β-cells

Toshiko Yamazawa, Akiko Mizushima, Masamitsu lino
Dept. Pharmacol. , Grad. Sch. Med. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 75-75, 2006.

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O1G3-4 Ca2+ mobilization via ryanodine receptor type 2 in urinary bladder smooth muscle

Shingo Hotta1, Kozo Morimura1, Susumu Ohya1, Katsuhiko Muraki2, Hiroshi Takeshima3, Yuji Imaizumi1
1Dept. Mol. Cell. Pharmacol. , Grad. Sch. Pharm. Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Dept. Cell. Pharmacol. , Sch. Pharm. , Aichi Gakuin Univ. , Nagoya, Japan,, 3Dept. Med. Chem. , Grad. Sch. of Med. , Tohoku Univ. , Miyagi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 75-75, 2006.

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O1G3-5 Roles of ryanodin receptor in rate capability of beating ventricular myocytes in culture

Naofumi Tokutomi
Lab. Pharmacol. Div. Life Sci. Fac. Pharmac. Sci. Sojo Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 75-75, 2006.

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O1H3-1 Inward rectifier K+ channel regulates cell death in bovine capillary endothelial cells

Daiju Yamazaki1, Susumu Ohya1, Katsuhiko Muraki2, Kiyofumi Asai3, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol. , Grad. Sch. of Pharmaceut. Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Dept. Cell. Pharmacol. , Sch. of Pharm. , Aichi Gakuin Univ. , Nagoya, Japan,, 3Dept. Mol. Neurobiol. , Grad. Sch. of Med. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 76-76, 2006.

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O1H3-2 The role of TARP γ-8 (DVCC γ -8) in AMPA receptor localization and function in hippocampus

Mika Tsujita1, 2, Masahiro Fukaya3, Haruyuki Kamiya4, Manabu Abe2, Maya Yamazaki2, Etsuko Kushiya2, Rie Natsume2, Masahiko Watanabe3, Kenji Sakimura2
1Cent. Transdiscipl. Res. , Niigata Univ. , Niigata, Japan,, 2Dept. Cell. Neurobiol. Brain Res. Inst. Niigata Univ. , Niigata, Japan,, 3Dept. Anat. Hokkaido Univ. , Sapporo, Japan,, 4Dept. Mol. Neuroanat. Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 76-76, 2006.

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O1H3-3 Effects of glutamate receptor antagonists on radiation- or chemotherapy-induced emesis

Kouichi Yamamoto, Takashi Yamamoto, Keita Okamura, Takuya Nakasone, Saiko Moriyasu, Atsushi Yamatodani
School of Allied Health Sciences, Osaka University, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 76-76, 2006.

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O1H3-4 Altered desensitization profiles of the α7 nicotinic receptor with G423S mutation identified in a patient with schizophrenia

Soushi Kobayashi1, Hiroshi Tsuneki1, Kazue Takagi1, Syota Kagawa1, Masahiko Tsunoda2, Masahiko Murata3, Tadasu Matsuoka2, Tsutomu Wada1, Masayoshi Kurachi2, Ikuko Kimura1, Toshiyasu Sasaoka1
1Dept. Clin. Pharmacol. , Univ. of Toyama, Toyama, Japan,, 2Dept. Neuropsychiatry, Univ. of Toyama, Toyama, Japan,, 3National Hospital Organization Hokuriku Hospital, Toyama,
Journal of Pharmacological Sciences 100 (suppl.1) 76-76, 2006.

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O1H3-5 Developmental change in the calcium channel subtypes involved in the excitatory and inhibitory synaptic transmission onto cholinergic neurons in the rat basal forebrain

Toshihiko Momiyama
Div. Cereb. Struc. , Natl. Inst. Physiol. Sci, Okazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 77-77, 2006.

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O1J3-1 Effects of iNOS inhibitors on asthma depending on administration schedules

Masayoshi Abe1, Noriyuki Sakata2, Takeshi Katsuragi1
1Dept. Pharmacol. , Fukuoka Univ. Sch. Med. , Fukuoka, Japan,, 2Dept. Pathol. Fukuoka Univ. Sch. Med. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 77-77, 2006.

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O1J3-2 The mechanism for the inhibitory effect of H3 agonist, Sch50971 on nasal symptoms of chronic rhinitis model in mice

Emiko Yokota, Yukio Sugimoto, Chiaki Kamei
Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci, Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 77-77, 2006.

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O1J3-3 Protection against bleomycin-induced lung injury by p38 α knockout mice

Yuji Matsuo1, Mitsuko Furuya4, Tomoyuki Kuwaki5, Ben-Shiang Deng5, Kana Namiki2, Kouitirou Tatsumi6, Takayuki Kuriyama6, Tatsuhiko Sudo3, Sadao Kimura1, Yoshitoshi Kasuya1
1Dept. of Biochem. and Mol. Pharmacol. , Grad. Sch. of Med. Chiba Univ. , Chiba, Japan,, 2Dept. of Mol. Pharmacol. Pharmacother. , Chiba Univ. Grad. Sch. of Pharm. Sci. , Chiba, Japan,, 3RIKEN, Hirosawa, Wako, Saitama, Japan,, 4Dept. of Mol. Pathol. , Chiba Unic. Grad. Sch. Med. , Chiba, Japan,, 5Dep. t of Mol. & Integ. Physiol. , Chiba Univ. Grad. Sch. of Med. , Chiba, Japan,, 6Dept. of Respirol. , Chiba Univ. Grad. Sch. Med. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 77-77, 2006.

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O1J3-4 Integration of in vivo safety pharmacology core battery studies

Takeshi Miyamori, Fuminori Matsubara, Hiroaki Takahashi, Akihiro Kannou, Yuji Tsurubuchi
Pharmacological Research Laboratories Drug Safety Testing Center Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 78-78, 2006.

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O1J3-5 The role of PGD2 in sneezing and nasal rubbing induced by histamine in rats

Toshio Inoue1, 2, Ashequr. M. Rahman2, Chiaki Kamei2
1Ogawa & Co. , Ltd. Maihama Labolatory, Chiba, Japan,, 2Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 78-78, 2006.

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O1E4-1 Serofendic acid protects nigrostri-atal dopaminergic neurons in 6-hydroxy-dopamine rats

Masatoshi Inden1, Yoshihisa Kitamura1, Takashi Taniguchi1, Hachiro Sugimoto2, Akinori Akaike3
1Dept. Neurobiol. , 21st Century COE Program, Kyoto Pharm. Univ. , Kyoto, Japan,, 2Dept. Neurosci. Drug Discov. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan,, 3Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 78-78, 2006.

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O1E4-2 Effect of glutamate receptor and dopamine receptor on place aversion induced by naloxone in single-dose morphine-treated rats

Yoichi Kawasaki1, Hiroaki Araki2, Yoshihisa Kitamura1, Kazuhiko Shibata1, Yutaka Gomita1
1Dept. Clinic. Pharmacol & pharmacy, Okayama Univ. Graduate Sch. Med. & Dent. & Pharmaceutical Sci. , Okayama, Japan,, 2Div. Pharmacy, Ehime Univ. Hosp. , Ehime, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 78-78, 2006.

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O1E4-3 Studies on drug dependence (Rept. 416): Site specific modulation of astrocyte-related soluble factors in the development of rewarding effects induced by drugs of abuse

Mayumi Miyayake, Minoru Narita, Michiko Narita, Masahiro Shibasaki, Keiko Shindo, Atsushi Nakamura, Naoko Kuzumaki, Yasuyuki Nagumo, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 79-79, 2006.

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O1E4-4 Chondroitin sulfate E promotes the neurite outgrowth of dopaminergic neurons through phospholipase C-mediated signaling

Naoki Sotogaku, Akinori Nishi, Masatoshi Tanaka
Dept. Pharmacol. , Kurume Univ. Sch. Med. , Kurume, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 79-79, 2006.

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O1E4-5 Effects of dopamine receptor lig-ands on locomotor activity of mutant mice lacking NMDA receptors selectively in the neostriatum

Hirotaka Kataoka, Masayoshi Mishina
Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 79-79, 2006.

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O1F4-1 Infarct size-limiting effect of adrenomedullin is mediated by the opening of mitochondrial Ca2+ -activated K+ channels

Hirofumi Nishida1, 2, Toshiaki Sato1, Masaru Miyazaki2, Haruaki Nakaya1
1Dept. Pharmacol. , Chiba Univ. Grad. Sch. Med. , Chiba, Japan,, 2Dept. Gen. Surg. , Chiba Univ. Grad. Sch. Med. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 79-79, 2006.

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O1F4-2 Anti-sympathetic property of L/N-type Ca2+ channel blocker cilnidipine assessed in the halothane-anesthetized canine model

Hiroshi Iwasaki, Atsushi Sugiyama, Akira Takahara, Yuji Nakamura, Keitaro Hashimoto
Dept. Pharmacol. , Univ. Yamanashi, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 80-80, 2006.

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O1F4-3 Spatiotemporal analysis of shear stress-induced calpain activations in cultured human umbilical vein endothelial cells

Takuro Miyazaki, Kazuo Honda, Hisayuki Ohata
Dept. Pharmacol. , Showa Univ. Sch. Pharm. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 80-80, 2006.

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O1F4-4 Roles of Na+/Ca2+ exchanger in the regulation of myogenic tone in mice

Satomi Kita1, Mordecai. P. Blaustein2, Takahiro Iwamoto1
1Dept. Pharmacol. , Sch. Med. , Fukuoka Univ. , Fukuoka, Japan,, 2Dept. Phisiol. , Univ. Maryland Sch. Med. , Baltimore, USA
Journal of Pharmacological Sciences 100 (suppl.1) 80-80, 2006.

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O1F4-5 Conducted calcium responses to local KCI application in terminal arterioles from rat mesentery

Lars. J. Jensen1, Ryuji Inoue2, Niels-Henrik Holstein-Rathlou3, Yushi Ito1
1Dept. Pharmacol. , Grad. Sch. Med. Sci. , Kyushu Univ, Fukuoka, Japan,, 2Fukuoka Univ. , Fac. Med. , Dept. Physiol. , Fukuoka, Japan,, 3Div. Renal Cardiovasc. Physiol. , Dept. Med. Physiol. , Panum Inst. , Univ. Copenhagen, Copenhagen, Denmark
Journal of Pharmacological Sciences 100 (suppl.1) 80-80, 2006.

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O1G4-1 β2-adrenergic regulation of the phosphorylation of ERK in human osteoblasts

Koji Hirukawa, Akifumi Togari
Dept. Pharmacol. Aichi-Gakuin Univ. Sch. Dent. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 81-81, 2006.

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O1G4-2 Differentiation-inducing factor-1 suppresses alkaline phosphatase gene pro-moter through the TCF/LEF binding site in SaOS-2 cells

Etsuko Matsuzaki, Fumi Takahashi, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. , Fac. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 81-81, 2006.

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O1G4-3 Establishment and characterization of clonal cell lines derived from minia-ture swine periodontal ligament

Miho Ibi1, 3, Akira Ishisaki1, Matsuo Yamamoto2, Satoshi Wada1, Atsuro Yokoyama3, Masato Tamura1
1Dept. Oral Biochem. & Mol. Biol. , Graduate Sch. Dental Med. , Hokkaido Univ. , Sapporo, Japan,, 2Dept. Periodontol. , Showa Univ. Sch. Dentistry, Tokyo, Japan,, 3Dept. Oral Functional Prostho. , Graduate Sch. Dental Med. , Hokkaido Univ. , Sapporo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 81-81, 2006.

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O1G4-4 Regulation of human osteoblast differentiation by vitamin D

Yojiro Maehata1, Fumihiko Yoshino1, Hirofumi Shoji1, Shun-suke Takahashi1, Kazuo Todoki1, Shigeyuki Ozawa2, Yasumasa Kato2, Masaichi-Chang-il Lee1, Ryu-ichiro Hata2
1Division of Pharmacology, Department of Clinical Care Medicine, Kanagawa Dental College, Kanagawa, Japan,, 2Department of Biochemistly and Molecular Biology, Kanagawa Dental College, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 81-81, 2006.

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O1G4-5 Effects of extracellular ATP on cultured fibroblast-like cells from human cer-vical ligamentum flavum

Toshitada Sawada1, Keniti Furukawa1, Masaki Kisiya1, Kouta Kanemaru1, Kazuhiko Seya1, Shigeru Motomura1, Satoshi Tho2
1Dept. Pharmacol. , Hirosaki Univ. Sch. Med. , Hirosaki city, Japan,, 2Dept. Orthopedic sug, Hirosaki Univ. Sch. Med. , Hirosaki city, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 82-82, 2006.

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O1H4-1 Tissue-type plasminogen activator enhanced the permeability of blood brain barrier

Yasuhiro Suzuki1, Nobuo Nagai2, Desire Collen2, Kazuo Umemura1
1Dept. Pharmacol. , Hamamatsu Univ. Sch. Med. , Hamamatsu, Japan,, 2CMVB, Univ. Leuven, Campus Gasthuisberg, O & N, Leuven, Belgium
Journal of Pharmacological Sciences 100 (suppl.1) 82-82, 2006.

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O1H4-2 Assessment of antioxidant property of intravenous anesthetics using electron spin resonance (ESR) spectroscopy

Kyo Kobayashi1, Masanao Matsumoto1, Fumihiko Yoshino2, Hirofumi Shoji2, Shun-suke Takahashi2, Kazuo Todoki2, Masaichi-Chang-il Lee2, Kazuichi Yoshida1
1Division of Anesthesiology, Department of Clinical Care Medicine, Kanagawa dental college, Kanagawa , Japan,, 2Division of Pharmacology, Department of Clinical Care Medicine, Kanagawa dental college, Kanagawa , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 82-82, 2006.

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O1H4-3 An oligodendrocytes-specific marker, monoclonal antibody Rip, recognizes 2',3'-cyclic nucleotide 3'-phosphodiesterase (C N Pase)

Masatomo Watanabe1, Yoko Sakurai2, Kouichi Itoh1
1Lab. Mol. Pharmacol. , Facul. Pharmaceut. Sci. at Kagawa, Tokushima Bunri Univ. , Kagawa , Japan,, 2Proteomics, Tokyo Metropolitan Inst. Gerontology, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 82-82, 2006.

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O1H4-4 Identification and characterization of a novel FK506 binding protein that interacts with Plexin-A4

Oumi Nakajima1, Fumikazu Suto2, 3, Akihiro Iwamatsu4, Eisaku Kondo5, Hajime Fujisawa3, Yoshio Goshima1, 6, Fumio Nakamura1
1Dept. Mol. Pharmacol & Neurobiol. , Yokohama City Univ. Grad. Sch. Med. , Yokohama, Japan,, 2Div. Dev. , Inst. Genet. , Shizuoka, Japan,, 3Dept. Neurobiol. Nagoya Univ. Grad. Sch. Sci. , Nagoya, Japan,, 4Protein research network, Yokohama, Japan, Pathol. , Okayama Univ. Grad. Sch. Med. , Okayama, Japan,, 6JST. CREST. , Kawaguchi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 83-83, 2006.

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O1H4-5 Analysis for molecular interaction of contactin associated protein (Caspr)2 in central nervous system

Shigeru Oiso, Toshitaka Futagawa, Takehiko Miura, Kentaro Nishida, Yoshihisa Ishihara, Yasuo Takeda, Katsushi Yamada
Dept. Clin. Pharm. & Pharmacol. , Kagoshima Univ. Grad. Sch. Med. & Dent. Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 83-83, 2006.

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O1J4-1 Involvements of muscarinic receptors in electrical field stimulation-induced contraction of the mouse ileum

Tadayoshi Takeuchi1, Keisuke Tanaka1, Hidemitau Nakajima1, Minoru Matsui2, Yasu-Taka Azuma1
1Dept. Vet. Pharmacol. , Grad. Sch. Life Envi. Sci. , Osaka Pre. Univ. , Sakai, Japan,, 2Div. Neuronal Network, Inst. Med. Sci. Univ. of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 83-83, 2006.

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O1J4-2 The functional interaction between SK2 channel and nicotinic ACh receptor in enteric neurons of guinea pig ileum

Hidemitsu Nakajima, Hiroto Gotoh, Fumiaki Hata, Yasutaka Azuma, Tadayoshi Takeuchi
Dept. of Veterinary Pharmacology, Graduate Sch. of Life and Environmental Sciences, Osaka Prefecture Univ. , Sakai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 83-83, 2006.

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O1J4-3 Prophylactic effect of Lactobacillus casei strain Shirota on NSAID-induced small intestinal damage

Hikaru Nishio1, Toshio Watanabe2, Kazuhide Higuchi2, 3, Takashi Asahara3, Kouji Nomoto3, Shinichi Kato1, Tetsuo Arakawa2, Koji Takeuchi1
1Dept. Pharmacol. Exp. Ther. , Kyoto Pharm. Univ. , Kyoto, Japan,, 2Dept. Gastroenterol. , Osaka City Univ. Sch. Med. , Osaka, Japan,, 3Yakult Central Institute Microbiolog Res, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 84-84, 2006.

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O1J4-4 Regulatory mechanism of cap-saicininduced gastric HCO3- secretion: Involvement of sensory neurons, nitric oxide (NO) and prostaglandins (PGs)

Eitaro Aihara, Yoko Sasaki, Yoko Nomura, Fumitaka Ise, Koji Takeuchi
Dept. Pharmacol. Exp. Ther. , Kyoto Pharmaceutical Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 84-84, 2006.

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O1J4-5 Identification of prostaglandin E receptor subtypes relevant to gastric mucosal protection; a study using intravital microscopy

Youichiro Hattori1, 2, Takashi Ohno3, Takeo Saeki2, Sumito Mizuguchi3, Katsuharu Arai2, Katsunori Saigenji2, Masataka Majima1
1Dept. Mol. Pharmacol. , Grad. Sch. Med. Sci. , Kitasato Univ. , Sagamihara, Japan,, 2Dept. Internal Med. , Kitasato Univ. Sch. Med, Sagamihara, Japan,, 3Isehara Kyodo Hosp. , Isehara, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 84-84, 2006.

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O1E5-1 CCKergic activation of orexin neurons via the CCKA receptor

Natsuko Tsujino, Akihiro yamanaka, Kanako Ichiki, Yo Muraki, Takeshi Sakurai, Katsutoshi Goto
Dept. Pharmacol. , Univ. of Tsukuba. Comprehensive human Sciences, Tsukuba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 84-84, 2006.

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O1E5-2 Modanifil activates the histamin-ergic system through the orexinergic system

Tomoko Ishizuka1, Tomotaka Murotani1, Masahiro Murakami1, Toshimi Sakurai2, Atsushi Yamatodani1
1Dept. Med. Phys. and Eng. , SAHS, Fac. Med. , Osaka Univ. , Osaka, Japan,, 2R&D Division, Alfresa Pharma Corp. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 85-85, 2006.

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O1E5-3 Effect of pituitary adenylate cyclase activating polypeptide (PACAP) on the tight junctions of the blood-brain barrier (BBB)

Kenzou Hazama1, 2, Shinsuke Nakagawa1, 4, Kunihiko Tanaka1, 4, Fuyuko Takata2, 4, Maria A Deli3, 4, Yasufumi Kataoka2, 4, Masami Niwa1, 4
1Dept. Pharmacol. 1, Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 2Dept. Pharm. Care Health Sci. Fac. Pharm. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 3Hungarian Academy Sci. , Szeged, Hungary,, 4PharmaCo-Cell Inc. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 85-85, 2006.

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O1E5-4 Adrenal A and NA cells and celiac sympathetic neurons were separately controlled by centrally administered arginine-vasopressin (AVP) and corticotropin-releasing factor (CRF) in rats

Naoko Yamaguchi, Shoshiro Okada, Takahiro Shimizu, Daisuke Usui, Liany Lu, Kumiko Nakamura, Kunihiko Yokotani
Neuropharmacol. , Neural Integration, Grad. Sch. of Medicine, Kochi Univ. , Kochi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 85-85, 2006.

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O1E5-5 Antidepressant-like effect of κ -opioid receptor agonist on learned helplessness model of depression in mice

Yuya Hasegawa, Takayoshi Mamiya, Makoto Ukai
Dept. Chem. Pharmacol. , Fac. Pharm. , Meijo Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 85-85, 2006.

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O1F5-1 A mechanism of sex-related differences in QT intervals: HERG channel blockade by estrogen

Junko Kurokawa1, Chang-Xi Bai1, Shoko Kakusaka1, Masaji Tamagawa2, Haruaki Nakaya2, Tetsushi Furukawa1
1Dept. Bio-informational Pharmacol. , MRI, Tokyo Med. & Dent. Univ. , Tokyo, Japan,, 2Dept. Pharmacol. , Chiba Univ. Grad. Sch. Med. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 86-86, 2006.

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O1F5-2 Inhibition of aldose reductase improves myocardial reperfusion injury by a dual mechanism

Kazumi Iwata, Kuniharu Matsuno, Toru Nishinaka, Chihiro Yabe-Nishimura
Dept. Pharmacol. , Kyoto Pref. Univ. Med. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 86-86, 2006.

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O1F5-3 Cardiac expression of mineralo-corticoid receptor contributes to cardiac remodeling after myocardial infarction

Yasuhiro Yamamoto, Yuichi Oshima, Takashi Ito, Zhigang Qiu, Tomomi Mohri, Yoriko Uozumi, Yasushi Kimura, Ryusuke Kimura, Kyoko Takahashi, Yasushi Fujio, Junichi Azuma
Dept. Clin. Evaluat. of Med. & Therapeut. , Grad. Sch. of Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 86-86, 2006.

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O1F5-4 Application of the first principle analysis to evaluate cardiac adenylyl cyclase stimulators

Haruki Eguchi1, Kousaku Iwatsubo2, Yoshihiro Ishikawa2
1Dept. Adv. Tech. , Tech. Res. Lab. , IHI, 1, Yokohama, Japan,, 2Dept. of Physiology and Medicine, Yokohama City University of Medicine, Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 86-86, 2006.

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O1F5-5 The functional significance and mechanisms of nucleo-cytoplasmic shuttling of SIRT1 in failing hearts

Masaya Tanno1, Jun Sakamoto2, Tetsuji Miura2, Kazuaki Shimamoto2, Yoshiyuki Horio1
1)Dept. Pharmacol. , Sapporo Medical Univ. Sch. Med. , Sapporo, Japan,, 2)2nd Dept. Internal Med. , Sapporo Medical Univ. Sch. Med. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 87-87, 2006.

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O1G5-1 Role of hydrogen sulfide as a novel endogenous nociceptive messenger

Tsuyoshi Ishiki, Yumi Maeda, Fumiko Sekiguchi, Atsufumi Kawabata
Div. Physiol. Pathophysiol. , Sch. Pharmaceut. Sci. , Kinki Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 87-87, 2006.

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O1G5-2 Immunohistochemical study of the GABAergic system in the mechanism of salivary secretion

Yasuhiro Kosuge, Mitsuru Kawaguchi, Kohei Sawaki
Dept. Pharmacol. , Tokyo Dent. Coll. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 87-87, 2006.

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O1G5-3 Facilitatory effect of hepatocyte growth factor (HGF) on redistribution of perivascular nerves in the rat mesenteric artery

Narumi Hobara, Mituhiro Goda, Fusako Takayama, Hiromu Kawasaki
Dept. Clin. Pharmac. Sci. , Grad. Sch. Med. Den. Pharmac. Sci. , Okayama Univ. , Okayama
Journal of Pharmacological Sciences 100 (suppl.1) 87-87, 2006.

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O1G5-4 A potential therapeutic target and drug for de-myelinating disease in the peripheral nervous system

Junji Yamauchi, Yuki Miyamoto, Akito Tanoue
Dept. Pharmacol. , Natl Res. Inst. Child Health Dev. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 88-88, 2006.

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O1G5-5 Chronopharmacological treatment with dexamethasone and salbutamol using nebulizing resets the circadian change of clock gene in OVA-sensitized asthmatic mice

Naomi Hayasaka1, Tomoyuki Kuwaki2, Fumiko Nidome1, Shigenobu Shibata1
1Dept. Pharmacol. , Sch. Sci. and Engineering, Waseda Univ. , Nishitokyo, Japan,, 2Dept. Molecular and Integrative Physiology, Grad. Sch. Med. , Chiba Univ. , Chiba-shi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 88-88, 2006.

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O1H5-1 Targeted DNA transfection into the mouse central nervous system using nanosecond pulsed laser-induced stress wave

Yasunari Kanda1, Yasushi Satoh2, Mitsuhiro Terakawa4, Shunichi Sato3, Minoru Obara4, Kunio Takishima2, Yasuhiro Watanabe1
1Dept. Pharmacol. , Natl. Def. Med. Coll. , Saitama, Japan,, 2Biochemistry I, Natl. Def. Med. Coll. , Saitama, Japan,, 3Div. Biomed. Info. Sci. , Natl. Def. Med. Coll. Res. Inst. , Saitama, Japan,, 4Dept. Electronics & Electrical Engineering, Keio Univ. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 88-88, 2006.

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O1H5-2 Neuronal circuits involved in the sensorimotor gating in mice

Kenji Takahashi, Taku Nagai, Hiroyuki Kamei, Kazuhiro Takuma, Kiyofumi Yamada
Lab. Neuropsychopharmacol. , Grad. Sch. Natu. Sci. Tech. , Kanazawa Univ. , Kanazawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 88-88, 2006.

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O1H5-3 Abnormal anxiety-related behavior in GPR7-deficient mice

Ruby Nagata1, 2, Makoto Ishii2, Youji Kitamura2, 3, Junko Hara3, Katsutoshi Goto3, Masashi Yanagisawa2, Takeshi Sakurai2, 3
1Kansei, Cognition and Neurosci. , Comprehensive Human Sci. , Ibaraki, Japan,, 2Yanagisawa Orphan Receptor Project, ERATO, JST, Tokyo, Japan,, 3Dept. Pharmacol, . Inst. Basic Med. Sci. , Univ. of Tsukuba, Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 89-89, 2006.

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O1H5-4 Generation of adenosine A3 receptor functionally humanized mice for the evaluation of the human antagonists

Kazuya Yamano, Miho Inoue, Shigehiro Masaki, Mayumi Saki, Michio Ichimura, Mitsuo Satoh
Pharmaceutical Research Center, Kyowa Hakko Kogyo Co. , Ltd. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 89-89, 2006.

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O1H5-5 Development of an in vivo animal model to monitor the extracellular neural amino acid in brain during behavior disorder at acute liver failure

Izumi Miura, Yumiko Isobe, Shuji Terai, Isao Sakaida
Department of Molecular Science and Applied Medicine (Gastroenterology and Hepatology) Yamaguchi University School of Medicine, Yamaguchi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 89-89, 2006.

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O1J5-1 Inhibitory effects of statins on cat-echolamine secretion from adrenal chromaf-fin cells

Eiichi Tachikawa1, Mubarak Hossain1, Yoshichika Yoshioka2, Kenzo Mizuma1, Kenzo Kudo1, Yukiko Kondo1, Yoshikazu Miyate3, Atsushi Kakizaki3, Eiichi Taira1
1Dept. Pharmacol. , Sch. Med. , Iwate Med. Univ. , Morioka, Japan,, 2High Field MRI Res. Insti. , Advanced Med. Sci. Res. Cen. , Iwate Med. Univ. , Takizawa, Japan,, 3Dept. Pharma. , Iwate Med. Univ. Hospital, Morioka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 89-89, 2006.

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O1J5-2 Role of Rho kinase in aldos-terone-induced renal injury

Akira Nishiyama, Guang-Ping Sun, Yukiko Nagai, Kayoko Miyata, Shoji Kimura, Youichi Abe
Dept. Pharmacol. , Kagawa Univ. Med. Sch. , Kagwa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 90-90, 2006.

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O1J5-3 Role of reactive oxygen species and ERK in injury of LLC-PK1 cells exposed to cisplatin

Masako Shirai, Yuko Kawata, Yuko Hikita, Misa Wada, Yuka Kohda, Yoshiko Kawai, Munekazu Gemba
Div. of Pharmacol. Osaka Univ. of Pharmaceut. Sci, Takatsuki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 90-90, 2006.

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O1J5-4 Altered nitric oxide synthase (NOS), arginase and ornthine decarboxylase (ODC) activities and polyamine biosynthesis in response to ischemia of rabbit detrusor

Keizo Kawano, Hitoshi Masuda, Masataka Yano, Kazunori Kihara, Hiroshi Azuma
Biosystem Regulation, Institute of Biomaterials & Bioengineering, Graduate School, Tokyo Medical & Dental University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 90-90, 2006.

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O1J5-5 Effect of propiverine on neuro-genic detrusor overactivity in spinal cord-injured rats

Masato Nanri1, Ryoji Mizumachi2, Nahoko Maeda2, Yumi Kuwata1, Tsukasa Kirimoto1, Toshinori Oka1
1Pharmacol. Research Group, Taiho Pharmaceutical Co. , Ltd. , Tokushima, Japan,, 2Dept. Pharamacol. , Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 90-90, 2006.

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O2E1-1 Neuroprotective effects of a novel vasoactive intestinal peptide derivative on ischemic cerebellar granule cell cultures with astrocytes

Daisuke Chino1, Yoshihiro Waki1, Takumi Sato1, Mao Miyamoto2, Atushi Isshiki2, Yasuo Watanabe1
1Dept. Pharmacolo & Pharmacoth. , Nihon Pharm Univ. , Saitama, Japan,, 2Dept. Anesth. , Tokyo Med Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 91-91, 2006.

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O2E1-2 Molecular mechanisms of selective dopaminergic neuronal loss caused by mutation of PINK1, a causative protein in autosomal recessive Parkinsonism

Yasuhiro Moriwaki1, 2, Yeon-Jeong Kim2, Yukari Ido1, Hidemi Misawa1, Koichiro Kawashima1, Ryosuke Takahashi2, 3
1Dept. Pharmacol. , Kyoritsu Univ. Pharmacy, Tokyo, Japan,, 2Lab. for Motor System Neurodegeneration. , BSL, RIKEN. , Saitama, Japan,, 3Dept. Neurology. , Grad. Sch. Med. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 91-91, 2006.

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O2E1-3 FKHR is dephosphorylated by cal-cineurin in mouse brain ischemia and its potential role in the neuronal death

Norifumi Shioda, Kohji Fukunaga
Dept. Pharmacol. , Tohoku Univ. Grad. Sch. Pharmaceut. Sci. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 91-91, 2006.

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O2E1-4 Altered gene expressions in rat hippocampus after kainic acid injection with or without manganese complexes of cur-cumin and diacetylcurcumin

Yaowared Sumanont1, Yukihisa Murakami1, Michihisa Tohda1, Kinzo Matsumoto1, 2
1Div. Medicinal Pharmacol. , Inst. Natural Med. , Univ. of Toyama, Japan,, 21st Century COE Program, Univ. of Toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 91-91, 2006.

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O2E1-5 Hepatocyte growth factor protected hippocampal neurons after transient fore-brain ischemia by preventing translocation of apoptosis-inducing factor into the nucleus

Makiko Niimura1, Norio Takagi1, Keiko Takagi1, Reiko Mizutani1, Naoko Ishihara1, Kunio Matsumoto2, Hiroshi Hunakoshi2, Toshikazu Nakamura2, Satoshi Takeo1
1Dept. Mol. Cell. Pharmacol. , Tokyo Univ. Pharm. Life Sci. , Hachioji, Japan,, 2Dept. Mol. Regenerative Med. , Osaka Univ. Sch. Med. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 92-92, 2006.

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O2F1-1 Determination of the prostaglandin F2α-response element in the promoter region of the NOX1 gene

Masato Katsuyama, Noriaki Arakawa, Chihiro Yabe-Nishimura
Dept. Pharmacol. , Kyoto Pref. Univ. Med. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 92-92, 2006.

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O2F1-2 Chymase inhibition prevents the progression of abdominal aortic aneurysm in dogs

Keiichi Furubayashi1, Shinji Takai2, Denan Jin2, Michiko Muramatsu2, Mizuo Miyazaki2
1Dept. Cardiovasc. Surg. , Osaka Med. Coll. , Osaka, Japan,, 2Dept. Pharmcol. , Osaka Med. Coll. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 92-92, 2006.

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O2F1-3 Human cardiac failure model of zebrafish

Yasuhito Shimada, Liqing Zang, Toshio Tanaka
Dept. Pharmacogenomics. , Mie Univ. Grad. Sch. Med. , Mie, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 92-92, 2006.

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O2F1-4 α-Lipoic acid reduces neointima formation after balloon injury in carotid artery of rats

Daisuke Kurumazuka1, Masanori Takaoka1, Hisashi Shirakawa1, Sayaka Kimura1, Tatsuhiko Mori2, Yasuo Matsumura1
1Dept. Pharmacol. , Osaka Univ. Pharmaceut. Sci. , Takatsuki, Japan,, 2Third Dept. Med. , Osaka Med. Col. , Takatsuki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 93-93, 2006.

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O2F1-5 Cordycepin (3'-deoxyadenosine) inhibits platelet aggregation by stimulating adenosine receptors

Noriko Yoshikawa1, Kazuki Nakamura1, Yu Yamaguchi1, Satomi Kagota2, Mariko Nagae1, Kazumasa Shinozuka2, Masaru Kunitomo1
1Dept. of Pharmacology I, Fac. of Pharmaceutical Sci. , Mukogawa Women's Univ. , Nishinomiya, Japan,, 2Dept. Of Pharmacology II, Fac. of Pharmaceutical Sci. , Mukogawa Women's Univ. , Nishinomiya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 93-93, 2006.

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O2G1-1 PGE2 receptor EP1 enhance Th1 differentiation

Daiji Sakata, Miyako Nagamachi, Kenji Kabashima, Tomoyuki Furuyashiki, Eri Segi-Nishida, Shuh Narumiya
Dept. of Pharmacol, Fuculty of Med. , the Univ. of Kyoto, Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 93-93, 2006.

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O2G1-2 Deficiency of c-Jun N-Terminal Kinase-1 enhances IL-10 production in macrophages

Yasu-Taka Azuma1, Elise Tran2, Tadayoshi Takeuchi1, Richard Flavell2
1Dept. Vet. Pharmacol. , Grad. Sch. Life and Environment. Sci. , Osaka Prefecture Univ. , Osaka, Japan,, 2Sect. Immunobiol. , Yale Univ. Sch. Med. , New Haven, CT 06520, USA
Journal of Pharmacological Sciences 100 (suppl.1) 93-93, 2006.

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O2G1-3 The physiological significance of diacylglycerol-activated TRPC3 channels in B cell receptor signalling

Takuro Numaga1, Yasuo Mori2
1Dept. Physiol. Sci. , Sch. Life Sc. , Grad. Sch. Adv. Studies, Aichi, Japan,, 2Dept. Synth. Biol. Chem. , Grad. Sch. Engineering, Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 94-94, 2006.

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O2G1-4 Anti-heat shock protein 70 anti-body production in sera of patients with rheumatoid arthritis

Kana Ogura1, Masahiko Suzuki2, Fumie Aosai3, Etsuko Negishi1, Hideshige Moriya2, Akihiko Yano3, Koichi Ueno1
1Dept. of Geriatric Pharmacol. and Ther. , Grad. Sch. of Pharm. Sci. , Chiba Univ. , Chiba, Japan,, 2Dept. of Orthopedic Surgery, Grad. Sch. of Med. , Chiba Univ. , Chiba, Japan,, 3Dept. of Infection and Host Defense, Grad. Sch. of Med. , Chiba Univ. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 94-94, 2006.

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O2G1-5 Carrier effect of p47phox and p40Phox in activation of Nox2

Toshihiko Tatuno, Takehiko Ueyama, Satoshi Tujibe, Yasuhito Shirai, Naoaki Saito
Biosignal Research Center, Kobe University, , Kobe-shi, Hyogo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 94-94, 2006.

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O2H1-1 Differential identification of mast cells and basophils increased in the lung in a murine model of asthma

Takeshi Nabe, Akari Sakamoto, Shigekatsu Kohno
Dept. Pharmacol. , Kyoto Pharm. Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 94-94, 2006.

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O2H1-2 Changes of nasal blood vessels in thromboxane (TX) A2 mimetic, U46619-induced nasal blockage in a guinea pig model of allergic rhinitis

Yoshiki Tanaka, Yasutomo Nakanishi, Nobuaki Mizutani, Takeshi Nabe, shigekatsu Kohno
Dept. Pharmacol. , Kyoto Pharm. Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 95-95, 2006.

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O2H1-3 Contribution of anaphylatoxin C5a to allergic inflammation in human lungs

Masayoshi Abe1, Hiroshi Hama3, Akinori Iwasaki2, Takayuki Shirakusa2, Nobuhumi Ono3, Takeshi Katsuragi1
1)Dept. Pharmacol. , Fukuoka Univ. Sch. Med. , Fukuoka, Japan,, 2)2nd Dept. Surg. , Fukuoka Univ. Sch. Med. , Fukuoka, Japan,, 3)Dept. Drug. Inform. , Fukuoka Univ. Pharm. Sci, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 95-95, 2006.

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O2H1-4 Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3

Tomonori Kunikata1, Hana Yamane2, Toshiyuki Matsuoka1, Hiroyuki Tanaka3, Hiroichi Nagai3, Shuh Narumiya1
1Dept. Pharmacol. , Kyoto Univ. Fac. Med. , Kyoto, Japan,, 2Dept. Physiol. Chem. , Kyoto Univ. Fac. Pharm. Sci. , Kyoto, Japan,, 3Dept. Pharmacol. , Gifu Pharm. Univ. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 95-95, 2006.

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O2H1-5 Identification of the regulatory elements involved in the intracellular localization of TLR3 and TLR7

Tadashi Nishiya1, 2, Emi Kajita1, Soichi Miwa1, DeFranco Anthony2
1Dept. Cellular Pharmacol. , Hokkaido Univ. Grad. Sch. Med. , Sapporo, Japan,, 2UCSF, San Francisco, USA
Journal of Pharmacological Sciences 100 (suppl.1) 95-95, 2006.

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O2E2-1 Neuroprotective effects of acetyl-cholinesterase inhibitors used in treatment of Alzheimer's disease against glutamate-induced apoptosis via nicotinic acetylcholine receptors

Yuki Takada-Takatori1, 2, Toshiaki Kume2, Hiroshi Katsuki2, Hachiro Sugimoto3, Akinori Akaike2
1Dept. Pharmacol. , Fac. Pharm. Sci. , Doshisha Women's College, Kyoto, Japan,, 2Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan,, 3Dept. Neurosci. for Drug Discov. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 96-96, 2006.

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O2E2-2 Involvement of the cortical dys-function of dopaminergic and glutamatergic signaling in the impairment of latent learning in mice treated with phencyclidine repeatedly

Akihiro Mouri1, Yukihiro Noda1, 2, Akihiro Noda1, Atsumi Nitta1, Hiroshi Furukawa3, Toshitaka Nabeshima1
1Dept. Neuropsychopharmacol and Hospital Pharm. , Nagoya. Univ. Grad. Sch. Med. , Nagoya, Japan,, 2Div. Clinical Sci. Facul. Pharm. , Meijo Univ, Nagoya, Japan,, 3Dept. Med Chem, Facul Pharm, Meijo Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 96-96, 2006.

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O2E2-3 Effect of Colivelin on Alzheimer's disease-relevant insults

Marina Yamada1, 2, Tomohiro Chiba1, Yuichi Hashimoto1, Maiko Sato1, Jumpei Sasabe1, 2, Kenzo Terashita1, Sadakazu Aiso2, Ikuo Nishimoto1, Masaaki Matsuoka1
1Dept. Pharmacol. , Keiu Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Anatomy, Keio Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 96-96, 2006.

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O2E2-4 Angiotensin II Type 2 receptor stimulation enhances neural differentiation and attenuates cognitive decline after focal cerebral ischemia through MMS2-inducntion

Masaki Mogi, Jian-Mei Li, Jun Iwanami, Li-Juan Min, Kana Tsukuda, Masaru Iwai, Masatsugu Horiuchi
Dept. of Molecular and Cellular Biology, Div. of Medical Biochemistry and Cardiovascular Biology, Ehime Uni. Sch. Med. , Ehime, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 96-96, 2006.

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O2E2-5 Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

Koji Aoyama1, Sang Won Suh2, Aaron M. Hamby2, Yongmei Chen2, Raymond A. Swanson2, Toshio Nakaki1
1Dept. Pharmacol. , Teikyo Univ. Sch. Med. , Tokyo, Japan,, 2UCSF, San Francisco, U. S. A.
Journal of Pharmacological Sciences 100 (suppl.1) 97-97, 2006.

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O2F2-1 Can natural vanadium-containing Mt. Fuji ground water improve glucose intol-erance?: morphological and molecular experiments using KK-Ay mice

Ikuo Shibuichi1, Masaaki Yasue2, Hiromichi Mitsuda1, Eiichi Kawamoto3, Kazuhiko Shirama4, Yasuo Watanabe5
1Bev. Res. & Dev. Lab. , Asahi Soft Drinks. , LTD. , Ibaraki, Japan,, 2Fundamental Res. Lab. , Asahi Breweries. , LTD. , Ibaraki, Japan,, 3Animal Res. Center, Tokyo Med. Univ. , Tokyo, Japan,, 4Dept. Anatomy, Tokyo Med. Univ. , Tokyo, Japan,, 5Dept. Pharmacol. & Pharmacotherapy, Nihon Pharmaceutical Univ. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 97-97, 2006.

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O2F2-2 Amelioration of STZ-Induced diabetic rat nephropathy by n-hexacosanol

Motoaki Saito1, Yukako Kinoshita1, Jiro Uemasu2, Hiroto Suzuki3, Masashi Yamada3, Keisuke Satoh1
1Dept. of Pathophysiology and Theraupeutic Sci. , Div. of Mol. Pharmacol. , Tottori Univ. Faculty of Med. , Yonago, Japan,, 2Uemasu Clinic, Yonago, Japan,, 3Meiji Daivies Corporation Pharmaceuticals Dept. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 97-97, 2006.

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O2F2-3 Involvement of increase in intra-cellular calcium concentration and PKC α activation in LLC-PK1 cell injury induced by zinc

Sachiko Tamai, Yoshiko Matsunaga, Yuki Ishida, Hitomi Nakamura, Yoshiko Kawai, Yuka Kohda, Munekazu Gemba
Div. of Pharmacol. Osaka Univ. of Pharmaceut. Sci. , Takatsuki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 97-97, 2006.

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O2F2-4 Molecular identification and functional characterization of a novel Organic Anion Transporter OAT9 that is expressed in brain and kidney

Taku Hirata, Babu Ellappan, Naohiko Anzai, He Xin, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. , Kyorin Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 98-98, 2006.

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O2F2-5 Inhibitory effect of adiponectin on PDGF-induced migration and proliferation in rat mesangial cells

Keisuke Ishizawa1, Rika Sugimoto1, Hironori Taira1, Yuki Izawa2, Koichiro Tsuchiya3, Kazuo Minakuchi1, Toshiaki Tamaki2
1Dept. Pharmacy, Tokushima Univ. Hosp. , Tokushima, Japan,, 2Dept. Pharmacol. , Inst. HBS, Univ. Tokushima Grad. Sch. , Tokushima, Japan,, 3Dept. Clin. Pharmacol. , Inst. HBS, Univ. Tokushima Grad. Sch. , Tokushima, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 98-98, 2006.

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O2G2-1 Study of neuropathic pain mechanisms III - Lysophosphatidic acid (LPA)-induced demyelination in explant culture and its mechanisms

Norikazu Kiguchi, Ryousuke Fujita, Hiroshi Ueda
Div. Mol. Pharmacol. & Neurosci. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 98-98, 2006.

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O2G2-1 Study of neuropathic pain mechanisms III - Lysophosphatidic acid (LPA)-induced demyelination in explant culture and its mechanisms

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O2G2-3 The activation of TP thromboxane A2 receptors induces itch-associated responses in mice

Tsugunobu Andoh1, Yumi Nishikawa1, Tomomi Yamaguchi-Miyamoto1, Hiroshi Nojima1, Shu Narumiya2, Yasushi Kuraishi1, 3
1)Dept. Applied Pharmacol. , Fac Pharm. Sci. , Univ. Toyama, Toyama, Japan,, 2)Dept. Pharmacol. , Fac. Med. , Kyoto Univ. , Kyoto, Japan,, 3)21st Century COE Program, Uni. Toyama, Toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 99-99, 2006.

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O2G2-4 Involvement of enteric glial COX-PGE2 pathway in responses of cultured rat myenteric neurons to bradykinin

Matsuka Murakami, Toshio Ohta, Ken-ichi Otsuguro, Shigeo Ito
Dept. Pharmacol. , Hokkaido Univ. Sch. Vet. , Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 99-99, 2006.

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O2G2-5 Regulatory mechanism of gastric hyperemic response after barrier disruption: roles of prostaglandin (PG)/EP receptor sub-types and sensory neurons

Tohru Kotani, Kazuhiro Fukushima, Kikuko Amagase, Koji Takeuchi
Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 99-99, 2006.

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O2H2-1 Influence of cytokines on CD20 expression and Rituximab-induced CDC on MC/CAR myeloma cells

Masanori Umeda1, Yasunobu Kuraishi1, Shuzo Nakai2, Katsuo Furukawa2, Satomi Akahane2, Hiromichi Tsuru2
1Div. Hematol. Oncol. , Toho Uni. Sch. Med. , Tokyo, Japan,, 2Dept. Pharmacol. , Toho Uni. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 99-99, 2006.

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O2H2-2 SLURP-1 and SLURP-2 gene expression patterns in C57BL/6J mice

Ken Yoshikawa, Yoshihito Fujii, Yasuhiro Moriwaki, Koichiro Kawashima
Dept. Pharmacol. , Kyoritsu Col. Pharmacy, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 100-100, 2006.

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O2H2-3 Autoantibody epitope mapping on human prolactin (PRL) molecule in macroprolactinemia

Naoki Hattori, Yasuhisa Nakayama, Kaori Kitagawa, Tiesong Li, Chiyoko Inagaki
Dept. Pharmacol. , Kansai Med. Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 100-100, 2006.

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O2H2-4 Effect of statins on immune response in monocytes

Hideo Takahashi, Shuji Mori, Masahiro Nishibori
Dept. Pharmacol. , Okayama Univ. Grad. Sch. of Med. Dent. & Pharm. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 100-100, 2006.

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O2H2-5 Hyperhomocyseinemia (Hcy) increases the expression of inflammatory cytokines in retina of streptozocine (STZ)-induced diabetic rats

Makiko Maeda1, 2, Yasushi Fujio1, Jooyeon Kim1, Takashi Ito1, Junichi Azuma1
1Dept. Clinical Evaluation of Medicines and Therapeutics, Osaka Univ. Sch. Med, Osaka, Japan,, 2The Japan Association for the Advancement of Medical Equipment, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 100-100, 2006.

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O2E3-1 Fibronectin upregulates expression of P2X4 receptors in microglia

Makoto Tsuda1, Emiko Kunifusa1, Kaoru Nasu-Tada2, Schuichi Koizumi2, Kazuhide Inoue1
1Dept. Mol. Syst. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan,, 2Dept. Pharmacol. , NIHS, Department of Pharmacology, National Institute of Health Sciences
Journal of Pharmacological Sciences 100 (suppl.1) 101-101, 2006.

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O2E3-2 GABAB2 receptor subunit in het-erodimerized GABAB receptors selectively transduces signal via the GABAB2 receptor-associated G proteins

Yasuhito Uezono1, Masato Kanaide1, 2, Muneshige Kaibara1, Minoru Hojo2, Masanori Matsumoto2, Yasuhiro Yoshida1, Koji Sumikawa2, Kohtaro Taniyama1
1Dept. Pharmacol. , Nagasaki Univ. , Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 2Dept. Anesthesiol. , Nagasaki Univ. , Grad. Sch. Blomed. Sci. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 101-101, 2006.

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O2E3-3 Differential roles of Ca 2+/calmod-ulin-dependent protein kinase I and IV on the dendritic development of hippocampal neurons

Akifumi Kamata1, Hiroyuki Sakagami2, Hisatake Kondo2, Kohji Fukunaga1
1Dept. Pharmacol. , Grad. Sch. Pharmaceu. Scis. , Tohoku Univ. , Sendai, Japan,, 2Div. Histol. , Dept. Cell Biol. , Grad. Sch. Med. , Tohoku Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 101-101, 2006.

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O2E3-4 Redox regulation of the calcium/calmodulin-dependent protein kinase

Yasuo Watanabe, Naoya Hatano, Katsuyoshi Sugimoto, Tao Song, Fuminori Yamaguchi, Masaaki Tokuda
Dept. Cell Physiol. , Kagawa Univ. Faclt. Med. , Kagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 101-101, 2006.

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O2E3-5 Calcium imaging of neurons with an improved G-CaMP

Junichi Nakai1, Masamichi Ohkura2, Keiji Imoto3, Masanori Matsuzaki4, Haruo Kasai4, Dierk Reiff5
1RIKEN, BSI, Lab for memory and learning, Saitama, Japan,, 2Kyushu Univ. of Health & Welfare, Sch. Pharmac. , 1st Dept. of Pharmac. , Miyazaki, Japan,, 3NIPS Divisiotn of neural signaling, Auchi, Japan,, 4NIPS Dept. Cell Physiol. & Univ. Tokyo, Auchi, Japan,, 5Max-Planck-Inst. Neurobiol. Dept. System & Computational Neurosci. , Martinsried, , Germany
Journal of Pharmacological Sciences 100 (suppl.1) 102-102, 2006.

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O2F3-1 MAP kinases activated by stimulation of endoplasmic M1 muscarinic acetylcholine receptors (mAChRs)

Shigeru Morishima, Abu Syed Md Anisuzzaman, Fumiko Suzuki, Hatsumi Yamamoto, Takashi Tanaka, Ikunobu Muramatsu
Div. Pharmacol. , Dept. Biochemistry and Bioinformative Sciences, Fukui Univ. Sch. Med. , Fukui, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 102-102, 2006.

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O2F3-2 The degradation of NFAT5 is induced by doxorubicin and impairs cell via-bility in cardiomyocytes

Takashi Ito, Yoriko Uozumi, Yuki Hoshino, Mika Takai, Makiko Maeda, Yasuhiro Yamamoto, Tomomi Mohri, Yasushi Kimura, Yasushi Fujio, Junichi Azuma
Dept. Clin. Evaluat. of Med. Therapeut. , Pharm. Sch. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 102-102, 2006.

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O2F3-3 Epigallocatechin gallate, a major polyphenol in green tea, binds to cardiac tro-ponin C and desensitizes cardiac muscle contraction to Ca2+

Tadano Naoto1, 2, Fumiaki Yumoto3, 4, Sachio Morimoto1, Koji Nagata3, Mika Ohta1, 5, Misao Suzuki6, Qun-Wei Lu1, Naoto Oka7, Cheng-Kun Du1, Fumi Takahashi-Yanaga1, 7, Yoshikazu Miwa1, Tsutomu Imaizumi7, Ken-ichi Yamamura5, Masaru Tanokura3, Iwao Ohtsuki4, Toshiyuki Sasaguri1
1)Dept. Clin. Pharmacol. , Kyushu Univ. Fac. Med. Sci. , Fukuoka, Japan,, 2)Dept. Pharmacol. , Cent. Res. Inst. , Zenyaku Kogyo, Co. Ltd. , Tokyo, Japan,, 3)Dept. Appl. Biol. Chem. , Grad. Sch. Agri. Life Sci. , Univ. Tokyo, Tokyo, Japan,, 4)Dept. Physiol. , Jikei Univ. Sch. Med. , Tokyo, Japan,, 5)Inst. Mol. Enbryol. Genet. , Kumamoto Univ. , Kumamoto, Japan,, 6)CARD, Kumamoto Univ. , Kumamoto, Japan,, 7)3rd Dept. Med. , Kurume Univ. Sch. Med. , Kurume, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 102-102, 2006.

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O2F3-4 A knock-in mouse model for dilated cardiomyopathy caused by δ K210 mutation in cardiac troponin T and its pathogenic mechanism

Sachio Morimoto1, Sheng-Kun Du1, Kiyomasa Nishii2, Qun-Wei Lu1, Reiko Minakami3, Mika Ohta1, Naoto Oka4, Hiroshi Miyazaki4, Naoto Tadano1, 5, Jun-ichi Miyazaki6, Tsutomu Imaizumi4, Toshiyuki Sasaguri1, Iwao Ohtsuki7
1)Dept. Clin. Pharmacol. , Kyushu Univ. Fac. Med. Sci. , Fukuoka, Japan,, 2)Dept. Cell Biol. , Sch. Med. , Tokyo Med. Dent. Univ. , Tokyo, Japan,, 3)Dept. Health Sci. , Kyushu Univ. Sch. Med, Fukuoka, Japan,, 4)3rd Dept. Med. , Kurume Univ. Sch. Med. , Kurume, Japan,, 5Dept. Pharmacol. , Cent. Res. Inst. , Zenyaku Kogyo, Co. Ltd. , Tokyo, Japan,, 6Div. Stem Cell Reg. Res. , Osaka Univ. Grad. Sch. Med. , Osaka, Japan,, 7Dept. Physiol. , Jikei Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 103-103, 2006.

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O2F3-5 Disordered-coagulation-associated gene silencing in septic rabbits using small interfering RNA (siRNA)

Naoyuki Matsuda1, Hiromi Yamazaki1, Satoshi Gando2, Yuichi Hattori1
1Dept. Pharmacol. , Sch. Med. , Univ. Toyama, Toyama, Japan,, 2Dept. Anesthesiol. Crit. Care Med. , Hokkaido Univ. Grad. Sch. Med. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 103-103, 2006.

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O2G3-1 Caveolae-dependent signaling pathway induced by endothelin but not angiotensin II receptors

Masashi Fukutomi, Takuya Murakami, Motohiro Nishida, Hitoshi Kurose
Dept. of Pharm. and Toxicol. , Grad. Sch. of Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 103-103, 2006.

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O2G3-2 Activation of matrix metallopro-teinase-9 by chymase after myocardial infarcion in hamsters

Katsuhiro Yoshikawa1, 2, Shinji Takai1, Denan Jin1, Michiko Muramatsu1, Yoshiki Mino2, Mizuo Miyazaki1
1Dept. Pharmacol. , Osaka Medical College, Osaka, Japan,, 2Dept. of Enviromental Analysis, Osaka University of Phaemaceutical Sciences, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 103-103, 2006.

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O2G3-3 Vascular responses of yolk-derived peptides in rat mesenteric arteries

Masataka Nomura1, Shoko Aono1, Teruyuki Kanada2, Takahiko Hada2, Husako Takayama1, Hiromu Kawasaki1
1Dept. Clin. Pharmac. Sci. , Grad. Sch. Med. Den. Pharmac. Sci. , Okayama Univ. , Okayama, Japan,, 2Dep Research and Development, Bizen Chemical Co. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 104-104, 2006.

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O2G3-4 Pitavastatin improves vascular dysfunction in insulin-resistant state by inhibiting NAD (P) H oxidase activity and uncoupled eNOS-dependent superoxide production

Kazuya Shinozaki, Kazuhide Ayajiki, Tomio Okamura
Dept. Pharmacol. , Shiga Univ. Med. Sci. , Shiga, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 104-104, 2006.

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O2G3-5 Role of angiotensin II on superox-ide production in rabbit cerebral resistance arteries following chronic administration of nitroglycerin in vivo

Junko Kajikuri, Yoshimasa Watanabe, Takeo Itoh
Dept. Mol. Cell. Pharmacol. , Nagoya City Univ. Grad. Sch. Med. Sci. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 104-104, 2006.

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O2H3-1 Effect of TS-022, a newly developed prostanoid DP1 receptor agonist, on experimental pruritis, cutaneous barrier dis-ruption and atopic dermatitis models in mice

Iwao Arai, Yuki Hashimoto, Yusuke Honma, Chie Koizumi, Nobuko Futaki, Masanori Sugimoto, Nobutaka Takahashi, Tomoyuki Inoue, Shirou Nakaike
Medicinal Research Lab. Taisho Pharmaceutical Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 104-104, 2006.

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O2H3-2 A new chronic itch model accompanied by skin lesions in hairless mice

Yuhki Ueda, Chiaki Kamei
Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 105-105, 2006.

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O2H3-3 Effects of Kujin-Plus, a novel formula of traditional Chinese herbal medicine, on severe atopic dermatitis in 64 patients

Songhua Li1, 2, Yuta Kobayashi1, Naomi Tamaru2, Ruwei Wang3, Sumio Iwasaki2
1Cent. Integr. Res. Sci, Shimane Univ. , Izumo, Japan,, 2Soujikai group Izumo Clinic, Izumo, Japan, 3Sejiang Natural Plants Institute, Sejiang, PRC
Journal of Pharmacological Sciences 100 (suppl.1) 105-105, 2006.

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O2H3-4 Ethanol intake aggravates itch-related scratching in special diet-fed hairless mice via indirect potentiation of peripheral itching sensation

Takeshi Nakamura, Masanori Fujii, Takeshi Nabe, Shigekatsu Kohno
Dept. Pharmacol. Kyoto Pharm. Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 105-105, 2006.

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O2H3-5 Interferon-γ increases extracellular ATP hydrolysis through up-regulation of ecto-nucleoside triphosphate diphosphohy-drolase 1 in J774 murine macrophages

Isao Matsuoka, Yen Tang, Tomoyuki Ono, Junko Kimura
Dept. Pharmacol. , Fukushima Med. Univ. Sch. Med. , Fukushima, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 105-105, 2006.

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O2F4-1 Effect of inhibitors of tetrahydro-biopterin (BH4) biosynthesis on vascular cell adhesion molecule-I (VCAM-I) expression

Takashi Matsumoto1, Kazuhisa Ikemoto2, Hiroaki Shiraishi2, Chiho Ichinose2, Mitsuyasu Ito1, Takahide Nomura2
1Dept. Endocrinology. Fujita Health Univ. , Aichi, Japan,, 2Dept Pharmacology Fujita Health Univ, Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 106-106, 2006.

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O2F4-2 TXA2 receptor blockade confers cerebroprotective effects through suppression of cerebrovascular inflammation

Toshiaki Ishizuka, Masaki Tabuchi, Atsuko Niwa, Yusuke Nagatani, Hideaki Higasino
Dept. Pharmacol. , Kinki Univ. Sch. Med. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 106-106, 2006.

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O2F4-3 Chronic nitroglycerine administration reduces hyperpolarization in endothelial cells of rabbit aortic valve

Nobuyoshi Kusama1, 2, Junko Kajikuri1, Yoshimasa Watanabe1, Takeo Itoh1
1Dept. Cell. Mol. Pharmacol. , Nagoya City Univ. Grad. Sch. Med. , Nagoya, Japan,, 2Dept. Med. Crisis. Manage. , Nagoya City Univ. Grad. Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 106-106, 2006.

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O2F4-4 Prevention of hyper-contractile response to thrombin by proteinase-activated receptor-1 antagonist in rabbit double subarachnoid hemorrhage model

Yasutoshi Kai, Katsuya Hirano, Mayumi Hirano, Naohisa Niiro, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol. , Res Inst Angiocardiol. , Grad. Sch. Med. Sci. , Kyushu Uni, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 106-106, 2006.

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O2F4-5 Comprison of polyglutamine-, tunicamycin- and thapsigargin-induced ER stress in PC12 cells

Hitoshi Nakayama1, Koji Shimoke2, Minoru Isosaki1, Hiroyasu Satoh1, Masanori Yoshizumi1, Toshihiko Ikeuchi2
1Dept. Pharmacol. Nara Med. Univ. Sch. Med, Nara, Japan,, 2Fac. of Engin. , Kansai Univ, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 107-107, 2006.

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O2G4-1 The regulation of CaMKII δ autophosphorylation in progression of car-diac hypertrophy in ovariectomized rats

Tomohiro Abe, Masami Hashimoto, Yusuke Takeuchi, Kohji Fukunaga
Dept. Pharmacol. , Grad. Sch. Pharmaceu. Scis. , Tohoku Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 107-107, 2006.

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O2G4-2 Oxidized LDL receptor LOX-1 is involved in diet-induced acute lipid-deposition in mesenteric artery of SHR-SP

Tatsuya Sawamura, Fumiaki Sugawara, Atsushi Nakano
Dept Vasc Phys, Natl Cardiovasc Ctr Res Inst, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 107-107, 2006.

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O2G4-3 Effect of pioglitazone on the high density lipoprotein expression in plasma of sucrose and high fat diet loaded sponta-neously hypertensive hyperlipidemic rats

Toshio Kumai, Naoki Matsumoto, Yuko Takeba, Sachiko Nakaya, Shinichi Kobayashi
Dept. Pharmacol. , St. Marianna Univ. Sch Med, Kawasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 107-107, 2006.

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O2G4-4 Modification of medial cell dynamics by cyclosporine A and everolimus in murine carotid allografts

Yuji Matsumoto1, Robert. P. Hof2
1Dept. Pharmacol. , Hamamatsu Univ. Sch. Med. , Shizuoka, Japan,, 2Novartis Institutes for BioMedical Research, Novartis Tsukuba Research Institute, Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 108-108, 2006.

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O2G4-5 Reversal of cardiac disease in CryAB R120G cardiomyopathy

Atsushi Sanbe1, Jeffrey Robbins2, Akito Tanoue1
1Dept. Pharmacol. , National Research Institute for Child Health and Development, Tokyo, Japan,, 2Div. Mol. Cardiovasc. Biol. Cincinnati Children's Hospital Research Foundation, Cincinnati
Journal of Pharmacological Sciences 100 (suppl.1) 108-108, 2006.

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O2H4-1 Cognitive enhancer nefiracetam recovered learning and memory functions through activation of CaM kinase II and PKC in the olfactory bulbectomized mice

Shigeki Moriguchi1, Feng Han1, Osamu Nakagawasai2, Takeshi Tadano2, Kohji Fukunaga1
1Dept. Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Tohoku Univ. , Sendai, Japan,, 2Dept. Pharmacol. Tohoku Pharmaceut. Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 108-108, 2006.

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O2H4-2 Effects of endomorphin-1 (EM-1) on impairment of learning and/or memory after blockade of glutamatergic system in mice

Hiroaki Kimata, Masayuki Hiramatsu
Lab. of Neuropsychopharmacol. , Grad. Sch. of Environ. and Human Sci. , Aichi Nagoya
Journal of Pharmacological Sciences 100 (suppl.1) 108-108, 2006.

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O2H4-3 CaM kinase I mediates hippocam-pal UP via CREB and myosin light chain phosphorylation

Takashi Komori, Shigeki Moriguchi, Kohji Fukunaga
Dept. Pharmacol. , Grad. Sch. Pharmaceu. Scis. , Tohoku Univ. , Miyagi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 109-109, 2006.

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O2H4-4 Frequency-dependent long-term potentiation of excitatory synapses in the mouse cerebellum regulated by nitric oxide signaling

Sho Kakizawa1, Shigeyuki Namiki1, 2, Kenzo Hirose1, 2, Masamitsu Iino1
1Dept. Pharmacol. , Grad. Sch. Med, Univ. Tokyo, Tokyo, Japan,, 2Dept. Cell Physiol. , Grad. Sch. Med. , Nagoya Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 109-109, 2006.

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O2H4-5 Facilitated cerebellar LTD and OKR adaptation in mice lacking Delphilin

Tomonori Takeuchi1, Takashi Yoshida2, Gen Ohtsuki2, Tomoo Hirano2, Tasuku Wainai1, Masahiro Fukaya3, Masahiko Watanabe3, Hisashi Mori1, Kenji Sakimura4, Susumu Kawamoto5, Masayoshi Mishina1
1Dept. Mol. Neurobiol. & Pharmacol. , Sch. Med. , Univ. Tokyo & SORST/JST, Tokyo, Japan,, 2Dept. Biophys. , Grad. Sch. Sci. , Kyoto Univ. & CREST/JST, Kyoto, Japan,, 3Dept. Anat. , Hokkaido Univ. Sch. Med. , Sapporo, Japan,, 4Dept. Cell Neurobiol. , Brain Res. Inst. , Niigata Univ. , Niigata, Japan,, 5Dept. Mol. Function, Res. Ctr. for Pathogenic Fungi & Microbial. Toxicoses, Chiba Univ. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 109-109, 2006.

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O2F5-1 Vascular response induced by a SOD mimetic, tempol, in rat mesenteric resistance arteries

Kazuo Nakamoto, Akitoshi Takeda, Fusako Takayama, Hiromu Kawasaki
Dept. Clin. Pharmac. Sci. , Grad. Sch. Med. Den. Phramac. Sci, Okayama Univ. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 109-109, 2006.

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O2F5-2 A phytosterol saponin of ginseng root (ginsenonside) is a mechanism-specific activator of sex steroid receptors

Chang-Xi Bai, Junko Kurokawa, Tetsushi Furukawa
Dept. Bio-informational Pharmacol. , MRI, Tokyo Med. & Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 110-110, 2006.

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O2F5-3 A critical amino acid residue responsible for calmodulin-dependent kinase II (CAMKII)-mediated activation of vascular receptor-operated Ca2+ entry channel TRPC6

Naomi Geshi1, 2, Shinichi Takahashi1, Yasuo Mori3, Yushi Ito2, Ryuji Inoue1
1Dept. Physiol. , Fukuoka Univ. Sch. Med. , Fukuoka, Japan,, 2Dept. Pharmacol. , Grad. Sch. Med. , Kyushu Univ. , Fukuoka, Japan,, 3Lab Mol. , Dept. Syn. Chem and Biol. Chem. , Grad. Sch. Engineer. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 110-110, 2006.

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O2F5-4 Store-operated Ca2+ entry in 3T3-L1 preadipocytes is not affected by cytoskeltal structure.

Chikara Otsubo1, Osamu Terasaka2, Takashi Udagawa1, Masahito Kawamura1, Keiichi Ikeda1, Noboru Nakamichi1, Seiji Hori1, Masahiro Kawamura1
1Department of Pharmacology 1, Jikei Univ. Sch. Med. , Tokyo, Japan,, 2Division of Biology, Jikei Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 110-110, 2006.

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O2F5-5 Effects of 4 α -phorbol 12,13-dide-canoate, a potent activator of Trpv4, on intracellular Ca2+ concentration and mem-brane currents in rat aortic myocytes

Ryoichi Tanaka1, Katsuhiko Muraki2, Susumu Ohya1, Yuji Imaizumi1
1Dept. , Mol. & Cellular Pharmacol. , Grad. , Sch. , of Pharmaceut. , Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Department of Cellular Pharmacolgy, School of Pharmacy, Aichi Gakuin University. , Dept. , Cellular Pharmacol. , Sch. , of Pharm. , Aichi Gakuin Univ. , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 110-110, 2006.

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O2G5-1 Analysis of gene expression in rat aortic smooth muscle cells after exposure to calcification medium

Kouta Kanemaru, Ken-Ichi Furukawa, Kazuhiko Seya, Toshitada Sawada, Masaki Kishiya, Shigeru Motomura
Dept. Pharmacol. Hirosaki Univ. School of Med. , Aomori, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 111-111, 2006.

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O2G5-2 Doxorubicin induces atrogin-1, a muscle-specific ubiquitin ligase through FOXO pathway

Yuki Hoshino, Yasushi Fujio, Takashi Ito, Tomomi Mohri, Yoriko Uozumi, Junichi Azuma
Dept. Clin. Evaluat. of Med. Therapeut. Phram. Sch. , Osaka Univ, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 111-111, 2006.

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O2G5-3 Decreased intracellular Ca2+ tran-sients in cardiomyocytes from transgenic mice overexpressing cardiac Na+/Ca2+ exchangers

Yasutoshi Hirabara1, 2, Satomi Kita1, Cheng-Kun Du3, Sachio Morimoto3, Ayako Furuta1, 2, Yukio Takano2, Michihiro Fujiwara4, Takeshi Katsuragi1, Takahiro Iwamoto1
1Dept. Pharmacol. , Sch. Med. , Fukuoka Univ. , Fukuoka, Japan,, 2Dept. Physiol. and Pharmacol. Sci. , Fac. Pharmaceut. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 3Dept. Clin. Pharmacol. , Med. Sch. , Kyushu Univ. , Fukuoka, Japan,, 4Dept. Neuropharmacol. , Fac. Pharmaceut. Sci. , Fukuoka Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 111-111, 2006.

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O2G5-4 Identification and characterization of a novel renal prostaglandin-specific organic anion transporter (OAT PG) structurally distinct from PGT

Naohiko Anzai1, Katsuko Shiraya1, Taku Hirata1, Promsuk Jutabha1, Ryo Hatano2, Satoshi Sanada2, Mitsunobu Matsubara2, Shigeaki Muto1, 3, Hitoshi Endou1, Yoshikatsu Kanai1
1Dept. Pharmacol. Toxicol. , Kyorin Univ. Sch. Med. , Tokyo, Japan,, 2Div. Mol. Med. , Tohoku Univ. Grad. Sch. of Med. , Miyagi, Japan,, 3Dept. Nephrol. , Jichi Med. Sch. , Tochigi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 111-111, 2006.

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O2G5-5 Taurine/ taurine transporter system contributes to cytoprotection and normal development in skeletal muscles

Yoriko Uozumi, Takashi Ito, Yuki Hoshino, Tomomi Mohri, Yasushi Kimura, Mika Takai, Kyoko Takahashi, Yasushi Fujio, Junichi Azuma
Dept. Clin. Evaluat. of Med. and Therapeut. Grad. Pharm. Sch. of Pharmaceut. Sci. Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 112-112, 2006.

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O2H5-1 Centrally administered histamine evokes the release of noradrenaline and adrenaline from adrenal medulla by brain thromboxane A2- and cyclooxygenase-1 -mediated mechanisms in rats

Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi, Tsuyoshi Sasaki, Kumiko Nakamura, Lianyi Lu, Kunihiko Yokotani
Neuropharmacol. , Neural Integration, Grad. Sch. of Medicine, Kochi Univ. , Kochi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 112-112, 2006.

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O2H5-2 Assessment of the sensitivity to an antidepressant in calcium/calmodulin-dependent protein kinase IV-deficient mice

Jiro Kasahara1, Hiroyuki Sakagami2, Hisatake Kondoh2, Kohji Fukunaga1
1Dept. Pharmacol. Grad. Sch. Pharmaceu. Sci. Tohoku Univ. , Sendai, Japan,, 2Dept. Histol. Grad. Sch. Med. Tohoku. Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 112-112, 2006.

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O2H5-3 The role of p38 in epileptic seizure

Kana Namiki1, 3, Mitsuko Furuya2, Yuji Matsuo1, Tatsuhiko Sudo4, Hiroshi Hama4, Shingo Yano3, Sadao Kimura1, Yoshitoshi Kasuya1
1Dept. Biochem. Mol. Pharmacol. , Grad. Sch. Med. , Chiba Univ. , Chiba, Japan,, 2Dept. Mol, Pathol. , Grad. Sch. Med. , Chiba Univ. , Chiba, Japan,, 3Dept. Mol. Pharmacol. Pharmacother. , Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba,, 4RIKEN, Hirosawa, Wako, Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 112-112, 2006.

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O2H5-4 Effects of antiepileptics on the changes of visual evoked potential induced by the lateral geniculate kindling in rats

Takashi Ishikawa, Jun Ago, Naotaka Matsumoto, Chiaki Kamei
Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 113-113, 2006.

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O2H5-5 Effects of exposure of sexual hormones during suckling period on the emotional and sexual behaviors in mice

Yoshiaki Kawai, Takayoshi Mamiya, Makoto Ukai
Dept. Chem. Pharmacol. , Fac. Pharm. , Meijo Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 113-113, 2006.

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O3E1-1 Studies on pain control system (Rept. 47): Role of increased intracellular Ca2+ observed in the spinal cord in the development of a neuropathic pain in mice

Mayumi Nakajima, Minoru Narita, Yoshinori Yajima, Mayumi Miyatake, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, Tokyo , Japan
Journal of Pharmacological Sciences 100 (suppl.1) 113-113, 2006.

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O3E1-2 Studies on pain control system (Rept. 50): Involvement of microglia in the ethanol-induced neuropathic pain-like state in rats

Kan Miyoshi, Minoru Narita, Michiko Narita, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 113-113, 2006.

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O3E1-3 Involvement of noradrenaline transmission within the bed nucleus of the stria terminalis in negative affective component of pain in rats

Satoshi Deyama1, 2, Naomi Akiyama2, Mikie Hirata2, Takayuki Nakagawa1, Shuji Kaneko1, Masabumi Mimami2
1Dept. of Mol. Pharmacol. , Grad. Sch. of Pharm. Sci. , Kyoto Univ. , Kyoto, Japan,, 2Dept. of Pharmacol. , Grad. Sch. of Pharm. Sci. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 114-114, 2006.

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O3E1-4 Interaction of the endocannabi-noid and glutamatergic system underlies relapse to methamphetamine seeking in rats

Katsuya Sakimura, Takato Hiranita, Kazuhide Inoue, Tsuneyuki Yamamoto
Dept. Pharmacol. , Grad. Sch. Pharm. Sci, Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 114-114, 2006.

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O3E1-5 Studies on drug dependence (Rept. 418): Implication of Neuronal Wiskott-Aldrich Syndrome Protein (N-WASP) in the methamphetamine-induced rewarding effect

Tomoko Tanaka, Minoru Narita, Tsutomu Suzuki
Dept. Toxical. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 114-114, 2006.

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O3F1-1 Mechanisms of pressor response induced by nitric oxide synthase inhibitor L-NAME in rats

Shinichi Neki, Nobuyuki Hanafusa, Fusako Takayama, Hiromu Kawasaki
Dept. Clin. Pharmac. Sci. , Grad. Sch. Med. Dent. Pharmac. Sci. , Okayama Univ. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 114-114, 2006.

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O3F1-2 Alterations of intracellular calcium concentration and NO production in rabbit pulmonary artery endothelium after sub-arachnoid hemorrhage

Yoshihiro Kubota1, Eiji Isotani1, Yusuke Mizuno1, Kikuo Ohno1, Hiroshi Azuma2
1Dept. Neurosurg. , Graduate Sch. , Tokyo Medical and Dental Univ. , Tokyo, Japan,, 2Institute of Biomaterials and Bioengineering, Tokyo Med. & Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 115-115, 2006.

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O3F1-3 Are nitrite and nitrosothiols signifi-cantly involved in physiological regulation of hemodynamics?

Takaharu Ishibashi, Tomoko Miwa, Ikumi Shinkawa, Junko Yoshida, Matomo Nishio
Dept. Pharmacol. , Kanazawa Med. Univ. , Ishikawa, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 115-115, 2006.

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O3F1-4 Inhibitory effect of endothelium-derived relaxing factors (EDRF) on agonist-induced excess vasoconstriction and the effect of aging in rat mesenteric resistance arteries

Yukiko Otonashi, Satoko Uchibori, Fusako Takayama, Hiromu Kawasaki
Dept. Clin. Pharmac. Sci. , Grad. Sch. Med. Den. Pharmac. Sci. , Okayama Univ. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 115-115, 2006.

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O3F1-5 Mechanisms of hypertention in 5/6 nephrectomized rats : possibile thera-peutics

Kohei Yamamizu1, 2, Kazuya Shinozaki2, Kazuhide Ayajiki2, Munekazu Gemba1, Tomio Okamura2
1Div. Pharmacol. , Osaka Univ. Pharm. Sci. , Osaka, Japan,, 2Dept. Pharmacol. Shiga Univ. Sci. Med, Shiga, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 115-115, 2006.

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O3G1-1 The regulation of large conduc-tance Ca2+ -activated K+ channel expressions brings spontaneous contractions in vas deference from castrated-rat

Akitoshi Ohno1, Susumu Ohya1, Katsuhiko Muraki2, Yuji Imaizumi1
Univ. , Nagoya, Japan,, 2Department of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Aichi lyoeum University. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 116-116, 2006.

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O3G1-2 Functional role of ATP-sensitive K+ channels in nodal cells during hypoxia: reevaluation using Kir6.2-null mice

Koichi Fukuzaki1, Masaji Tamagawa1, Takashi Miki2, Susumu Seino2, Haruaki Nakaya1
Dept. Pharmacol. , Chiba Univ. , Chiba, Japan,, 2Div. Cell. & Mol. Med. , Kobe Univ. , Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 116-116, 2006.

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O3G1-3 Molecular properties of channel pore regions in native smooth muscle-type ATP-sensitive K+ channels

Noriyoshi Teramoto, Manami Aishima, Hai-Lei Zhu, Yushi Ito
Dept. Pharmacol. , Kyushu Univ. Graduate Sch. Med. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 116-116, 2006.

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O3G1-4 Effects of nicorandil on the trans-mural conduction slowing during ischemia in canine left ventricles

Masamichi Hirose, Mitsuhiko Yamada
Dept. Molecular Pharmacol. , Shinshu Univ. Sch. Med. , Matsumoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 116-116, 2006.

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O3G1-5 Effects of novel compounds derived from DiCDHA on the human BK channel

Yoshimi Toriumi1, Toshihiko Tashima1, Hiromichi Tsuru2, Tomohiko Ohwada1, Satomi Adachi-Akahane2
1Lab. Org. Med. Chem. , Grad. Sch. Pharmaceut. Sci. , the Univ. Tokyo, Tokyo, Japan,, 2Dept Pharmacol. , Fac. Med. , Toho Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 117-117, 2006.

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O3H1-1 Semaphorin3A selectively facili-tates the axonal transport of its receptor and intracellular signaling molecules

Naoya Yamashita1, Taiichiro Gotoh1, Hiroshi Usui1, Aiko Yamamoto1, Yukio Sasaki1, Fumio Nakamura1, Kohtaro Takei1, 2, Yoshio Goshima1, 2
1Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. Grad. Sch. Med. , Yokohama, Japan,, 2JST CREST, Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 117-117, 2006.

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O3H1-2 Molecular analysis of the EphA1 /ephrin system

Yoshiro Maru, Junko Masuda, Ryosuke Usui, Toru Yamazaki
Dept. Pharmacol. , Tokyo Women's Med. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 117-117, 2006.

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O3H1-3 Regulation of insulin receptor cell surface expression by glycogen synthase kinase- 3β activity

Hiroki Yokoo, Takayuki Nemoto, Toshihiko Yanagita, Shinya Satoh, Norie Yoshikawa, Toyoaki Maruta, Hideyuki Kobayashi, Akihiko Wada
Dept. Pharmacol. , Miyazaki Med. Coll. , Univ. Miyazaki, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 117-117, 2006.

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O3H1-4 Roles of spontaneous Ca2+ signals in astrocytes in neurite outgrowth

Kazunori Kanemaru1, Yohei Okubo1, Kenzo Hirose1, 2, Masamitsu Iino1
1Dept. Pharmacol. The Univ. Tokyo, Tokyo, Japan,, 2Dept. Cell Physiol. Nagoya Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 118-118, 2006.

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O3H1-5 Regulation of insulin receptor substrate-1/-2 expression by glycogen syn-thase kinase- 3β activity

Takayuki Nemoto, Hiroki Yokoo, Shinya Satoh, Toshihiko Yanagita, Norie Yoshikawa, Toyoaki Maruta, Hideyuki kobayashi, Akihiko Wada
Dept. Pharmacol. , Miyazaki Med. Coll. , Univ. Miyazaki, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 118-118, 2006.

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O3E2-1 The involvement of endocannabi-noid system in MDMA-seeking behavior ("craving to MDMA") in rats

Yoko Nawata, Takato Hiranita, Kazuhide Inoue, Tsuneyuki Yamamoto
Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 118-118, 2006.

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O3E2-2 Studies on pain control system (Rept.49) : Changes in cortical β -aminobu-tyric acid (GABA) ergic system under the neuropathic pain-like state in mice

Kana Nanjo, Minoru Narita, Michiko Narita, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 118-118, 2006.

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O3E2-3 Methamphetamine (METH) up-regulates L-type high voltage-gated calcium channels (HVCCs) through ryanodine receptor activation in the mouse brains

Masashi Katsura, Masahiro Shibasaki, Seitaro Ohkuma
Dept. Pharmacol. , Kawasaki Med. Univ. , Kurashiki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 119-119, 2006.

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O3E2-4 Studies on pain control system (Rept. 48): Involvement of a spinal JAK/STAT pathway in the development and maintenance of a neuropathic pain-like state in mice

Hiroyuki Nozaki, Minoru Narita, Michiko Narita, Yoshinori Yajima, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 119-119, 2006.

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O3E2-5 Inhibitory mechanisms of codeine on the excitatory synaptic transmission in second-order neurons of the nucleus tractus solitarius in guinea pig brainstem slices

Yoshiaki Ohi1, Akira Haji2, Yuichi Hattori1
1Dept. Pharmacol. , Sch. Med. , Univ. of Toyama, Toyama, Japan,, 2Lab. Neuropharmacol. , Sch. Pharm. , Aichi Gakuin Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 119-119, 2006.

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O3F2-1 Role of eNOS and NADPH oxidase in development of diastolic heart failure(DHF)

Eiichiro Yamamoto, Takuro Yamashita, Houichi Yorinaka, Yoshiko Tokutomi, Keiichiro Kataoka, Tomoko Tanaka, Shinji Matsuba, Shokei Kim-Mitsuyama
Dept. Pharmacology and Molecular Thrapeutics, Kumamoto Univ. Sch. Med. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 119-119, 2006.

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O3F2-2 Effects of antihypertensive drugs on enhanced nitric oxide production in aor-tas of SHR/NDmcr-cp (cp/cp) rats, a new animal model of metabolic syndrome

Satomi Kagota, Yoko Kubota, Namie Nejime, Yu Yamaguchi, Kazuki Nakamura, Masaru Kunitomo, Kazumasa Shinozuka
Dept. Pharmacol. , Sch. Pharmaceu. Sci, Mukogawa Women's Univ. , Nishinoiniya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 120-120, 2006.

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O3F2-3 Ethanol rapidly increases endothelial nitric oxide

Masamichi Tajima, Hiroshi Sakagami
Div. Dental Pharmacol. , Meikai Univ. Sch. Dent. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 120-120, 2006.

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O3F2-4 Reversal by oligonol, an oligomerized plant polyphenol, of high glucose-reduced nitric oxide release in endothenal cells

Xiaohong Zhang1, Naoyuki Matsuda2, Aya Hirose1, Eri Satou1, Hirosi Nisioka1, Hajime Fujii1, Yuuichi Hattori2
1Laboratory of Biochemistry, Amino UP Chemical Co. , Ltd. , Sapporo, Japan,, 2Department of Pharmacology, School of Medicine, University of Toyama, Toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 120-120, 2006.

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O3F2-5 ODQ suppresses myocardial apoptosis induced by hypoxia-reoxygenation

Kazuhiko Seva, Ken-Ichi Furukawa, Shigeru Motomura
Dept. Pharmacol. , Hirosaki Univ. Sch. Med. , Hirosaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 120-120, 2006.

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O3G2-1 Passive stretching produces Akt-and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice: A novel pharmaco-logical strategy for controlling glucose metabolism

Yoshihiko Ito, Kazuo Obara, Rikuko Ikeda, Megumi Ishii, Yoshiyuki Tanabe, Tomohisa Ishikawa, Koichi Nakayama
Dept. Cell Mol. Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Univ. Shizuoka, Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 121-121, 2006.

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O3G2-2 Membrane potential and current responses to carbachol in longitudinal smooth muscle cells of mice ileum genetically lacking M2 or M3 subtype of muscarinic receptors

Toshihiro Unno1, Takashi Sakamoto2, Hayato Matsuyama1, Masahisa Yamada3, Jurgen Wess4, Seiichi Komori1
1Lab. Pharmacol. , Dept. Vet. Med. , Gifu University. , Gifu, Japan. ,, 2Dept. Pathogenic Vet Med. , United Graduate Sch. , Gifu Univ. , Gifu, Japan. ,, 3Brain Sci. Inst. , RIKEN. , Saitama, Japan. ,, 4Lab. Bioorganic Chem. , Natl. Inst. DDKD. , Bethesda, USA.
Journal of Pharmacological Sciences 100 (suppl.1) 121-121, 2006.

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O3G2-3 Calcium sensitization and myosin light chain kinase activation in smooth muscle contraction

Eiji Isotani1, Yusuke Mizuno1, Kristine. E. Kamm2, James. T. Stull2, Kikuo Ohno1
1Dept. Neurosurg. , Tokyo Medical and Dental Univ. , Tokyo, Japan,, 2Dept. Physiol. UT Southwestern Medical Center, Dallas, USA
Journal of Pharmacological Sciences 100 (suppl.1) 121-121, 2006.

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O3G2-4 Down-regulation of intermediate conductance Ca2+ activated K+ channel in smooth muscle of voltage dependent Ca2+ channel β3 subunit deficient mouse

Kozo Morimura1, Susumu Ohya1, Hisao Yamamura1, Manabu Murakami2, Katsuhiko Muraki3, Kazuo Nunoki4, Teruyuki Yanagisawa5, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol. , Grad. Sch. of Pharmaceut. Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Dept. Pharmacol. , Akita Univ. Sch. Med. , Akita, Japan,, 3Dept. Cell. Pharmacol. , Sch. of Pharm. , Aichi Gakuin Univ. , Nagoya, Japan,, 4Dept. Human health & nutrition, Fac. Comprehensive Human Sci. , Shokei Gakuin College, Natori, Japan,, 5Dept. Mol. Pharmacol. , Tohoku Univ. Sch. Med. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 121-121, 2006.

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O3G2-5 Cyclohexenonic long-chain fatty alcohol reverses diabetic induced dysfunction of ileum in the rat

Chiko Shinbori1, Motoaki Saito1, Yukako Kinoshita1, Itaru Satoh1, Tomoharu Kono1, Eiji Nanba2, Kaori Adachi2, Hiroto Suzuki3, Masashi Yamada3, Keisuke Satoh1
1Dept. of Pathophysiology and Therapeutic Sci. , Div. of Mol. Pharmacol. , Tottori Univ. Faculty of Med. , Yonago, Japan,, 2GRC. , Tottori Univ. Faculty of Med. , Yonago, Japan,, 3Meiji Daivies Corporation Pharmaceuticals Dept. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 122-122, 2006.

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O3H2-1 Desensitization of the GABAB receptors by GRK4 and GRK5

Yasuhiro Yoshida1, Yasuhito Uezono1, Masato Kanaide1, 2, Minoru Hojo2, Koji Sumikawa2, Kohtaro Taniyama1
1Dept. Pharmacol. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 2Dept. Anesthesiol. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 122-122, 2006.

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O3H2-2 Functional analysis of novel growth suppressor Amida

Yasuyuki Irie1, Eiichi Taira2, Hidenori Kato3, Makio Saeki4, Yoshinori Kamisaki4, Yasuhiro Tukamoto3, Naomasa Miki1
1Dept. Pharmacol. , Osaka Univ. Grad. Sch. Med, Osaka, Japan,, 2Dept. Pharmacology Iwate Medical University, Iwate, Japan,, 3Dept. Vet. Anatomy, Osaka Pref. Univ. Sch. Life Envi. Sci. , Osaka, Japan,, 4Dept. Pharmacol. , Osaka Univ. Grad. Sch. Dent. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 122-122, 2006.

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O3H2-3 Functions of the cytoplasmic tails (C-tails) of the human receptor activity-modifying protein (RAMP) components of CGRP and adrenomedullin (AM) receptors

Kenji Kuwasako, Tanenao Eto, Kazuo Kitamura
First Dept. Intern. Med. , Miyazaki Med. Coll. , Univ. Miyazaki, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 122-122, 2006.

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O3H2-4 Exploring novel drug targets through the comprehensive analysis of human protein-drug interactions

Yorimasa Suwa, Tadakazu Yamauchi, Morikazu Kito, Kouichi Tsuchiya, Noriyuki Inomata, Katsuhisa Murayama, Kazuo Komiya, Tsuruki Tamura, Masato Umehara, Kousuke Hiroki, Yuko Isono, Takeshi Tsutsumi, Tsuyoshi Yamada, Hironori Oosaki, Hideaki Sueoka, Ken Horiuchi, Masashi Nemoto, Motoi Tobita, Tetsuo Nishikawa
Reverse Proteomics Research Institute Co. , Ltd. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 123-123, 2006.

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O3H2-5 Differential mechanisms of various beta adrenergic receptor antagonists by pharmacogenomics and pharmacoinformatics study

Takehiko Oka, Ryuhei Sou, Yasuhito Shimada, Toshio Tanaka
Department of Pharmacology and Pharmacogenomics, Mie, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 123-123, 2006.

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O3E3-1 Involvement of adenosine in depression of spinal reflex activity during hypercapnic acidosis in isolated spinal cord of neonatal rat

Ken-ichi Otsuguro, Yoshihiko Yamaji, Masaaki Ban, Toshio Ohta, Shigeo Ito
Lab. Pharmacol. , Dept. Biomed. Sci. , Grad. Sch. Vet. Med. Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 123-123, 2006.

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O3E3-2 Calpastatin degradation through caspase-3 activation mediates neuronal death following microsphere embolism in rats

Feng Han, Kohji Fukunaga
Dept. Pharmacol. , Graduate School of Pharmaceutical Sciences. , Tohoku Univ. , Miyagi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 123-123, 2006.

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O3E3-3 Hydrogen sufide protects neurons from oxidative stress

Yuka Kimura1, Richard Dargusch2, David Schubert2, Hideo Kimura1
1Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan,, 2The Salk Inst. for Biological Studies, La Jolla, USA
Journal of Pharmacological Sciences 100 (suppl.1) 124-124, 2006.

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O3E3-4 Characterization of sulfur in the brain released as hydrogen sulfide

Keiko Hiraki1, Makiko Tanaka1, Yuki Ogasawara2, Ken Umemura1, 3, Yuka Kimura1, Hideo Kimura1
1Molecular Genetics, National Institute of Neuroscience, Tokyo, Japan,, 2Dept. Environ. Biol. , Meiji pharmceut. Univ. , Tokyo, Japan,, 3Dept. Gene Therapy, Gifu International Inst. of Biotech. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 124-124, 2006.

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O3E3-5 The pH sensitivity of the human HCN3 channel

Hisao Yamamura, Naomi Itazu, Yoko Matsuoka, Susumu Ohya, Yuji Imaizumi
Dept. Mol. Cell. Pharmacol, Grad. Sch. Pharmaceut. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 124-124, 2006.

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O3F3-1 Roles of cardiac α 1B-adrenoceptor on contractile functions: studies in α 1B-AR-deficient mice

Yoshihisa Nasa1, Ryo Oikawa2, Yuji Kawahara2, Takashi Tomabechi2, Rie Ishii2, Naoko Suzuki2, Satoshi Takeo2, Akito Tanoue3, Gohzo Tsuzimoto4
1Dept. Funct. Morphol. Sci. , Nihon Pharm. Univ. , Kitaadachi-gun, Japan,, 2Dept. Mol. Cell. Pharmacol. , Tokyo Univ. Pharm. Life Sci. , Hachioji, Japan,, 3Dept. Mol. Cell. Pharmacol. Natl. Center Child Health, Tokyo, Japan,, 4Dept. Genom. Drug Discov. Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 124-124, 2006.

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O3F3-2 Synergistic interaction of neuropeptide Y Y1 receptor and α lA-adrenoceptor on the contractile response in rat arteries

Tatsuru Tsurumaki, Hong-Lan Piao, Shingo Nagai, Hiroshi Higuchi
Div. Pharmacol. , Niigata Univ. Grad. Sch. Med. Dent. Sci, Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 125-125, 2006.

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O3F3-3 Clathrin is essential for activation of G protein-coupled receptor kinases 2 (GRK2)

Supachoke Mangmool1, Tatsuya Haga2, Motohiro Nishida1, Hitoshi Kurose1
1Dept. of Pharm. and Toxicol. , Grad. Sch. of Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan,, 2Inst. for Biomol. Sci. , Facul. of Sci. , Gakushuin Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 125-125, 2006.

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O3F3-4 G protein β γ subunit is critical for ATP-induced NFAT activation in cardiac fibroblasts

Reiko Suda, Naoya Onohara, Motohiro Nishida, Hitoshi Kurose
Dept. of Pharm. and Toxicol. , Grad. Sch. of Pharm. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 125-125, 2006.

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O3F3-5 Proton mediates nicotine-induced adrenergic nerve-dependent and CGRPergic vasodilation in rat mesenteric resistance artery

Shu Zhang
Dept. Clin. Pharm. Sci. , Grad. Sch. Nat. Sci. Technol. , Okayama Univ. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 125-125, 2006.

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O3G3-1 Transport of nicotinate by human organic anion transporter hOAT2 and its possible interaction with transport of salicylate

Xin He, Naohiko Anzai, Takeshi Ueo, Toshiyuki Fukutomi, Takeshi Sakata, Hitoshi Endou, Yoshikatsu Kanai
Dept. of Pharmacol. and Toxicol. , Kyorin Univ. Sch. of Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 126-126, 2006.

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O3G3-2 Role of intracellular C-terminal domain of the catalytic subunit of system b0,+ for its trafficking and the protein-protein interaction

Naohiko Anzai1, Shinichi Sakamoto1, 2, Arthit Chairoungdua1, Tomohiko Ichikawa2, Hitoshi Endou1, Yoshikatsu Kanai1
1Dept. Pharmacol. Toxicol. , Kyorin Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Urol. , Chiba Uiv. Grad. Sch. of Med. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 126-126, 2006.

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O3G3-3 The role of the C-terminal domain in mouse β3 -adrenoceptor signalling

Takahiro Horinouchi1, 2, Masaaki Sato2, Dana. S. Hutchinson2, Bronwyn. A. Evans2, Yoshio Tanaka1, Katsuo Koike1, Roger. J. Summers2
1Dept. Chem. Pharmacol. , Toho Univ. Sch. Pharmaceut. Sci, Chiba, Japan,, 2Dept. Pharmacol. , Monash Univ. Sch. Med. , Victoria, Australia
Journal of Pharmacological Sciences 100 (suppl.1) 126-126, 2006.

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O3G3-4 Apoptosis-inducing effect of mevastatin on HL60 cells and its mechanism

Masanobu Tsubaki1, Masashi Yanae1, Chisato Kato1, Yoshihiro Tanimori2, Yoshiki Fujii1, Shozo Nishida1
1Dept. of Pharmacotherapy, Kinki Univ. Sch. of Pharmaceutical Sci. , Higashi-Osaka, Japan,, 2Kinki Univ. Attachment Hospital, Osaka-Sayama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 126-126, 2006.

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O3G3-5 PI3K/Akt/FOXO3a/p27Kip1 path-way contributes to thrombopoietin-induced proliferation of primary megakaryocytes

Takafumi Nakao1, Katsuyuki Miura2, Hiroshi Iwao1, Kenneth Kaushansky3
1Dept. Pharmacol. , Osaka City Univ. Med. Sch. , Osaka, Japan,, 2Appl. Pharmacol. Ther. , Osaka City Univ. Med. Sch. , Osaka, Japan,, 3Dept. Med. , UCSD, La Jolla, USA
Journal of Pharmacological Sciences 100 (suppl.1) 127-127, 2006.

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O3H3-1 Pimaric acid modulate voltage-gated K+ channels by binding its activation gate

Kazuho Sakamoto1, Susumu Ohya1, Katsuhiko Muraki2, Yuji Imaizumi1
1Dept. Mol. Cell. Pharmacology. , Grad. Sch. of Pharmaceutical Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Cell Pharmacology. Aichi Gakuin Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 127-127, 2006.

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O3H3-2 α -1A adrenoceptor (a1A-AR)-induced Ca2+ entry was augmented by a receptor-associated protein, snapin

Fumiko Suzuki, Shigeru Morishima, Takashi Tanaka, Ikunobu Muramatsu
Div. Pharmacol. , Dept. Biochemistry and Bioinformative Sciences, Fukui Univ. Sch. Med. , Fukui, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 127-127, 2006.

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O3H3-3 Interdomain interaction within type 1 ryanodine receptor involves dysfunction of Ca2+ release channel in malignant hyperthermia

Takashi Murayama1, Hideto Oyamada2, Nagomi Kurebayashi1, Toshiharu Oba3, Takashi Makino2, Hiroshi Hara4, Kikuo Wakebe4, Katsuji Oguchi2, Noriaki Ikemoto5, Yasuo Ogawa1
Pharmacol. , Showa Univ. Sch. Med. , Tokyo, Japan,, 3Dept. Physiol. , Nagoya City Univ. Med. Sch. , Nagoya, Japan,, 4Miyazaki St. , NLBC, Miyazaki, Japan,, 5Boston Biomed. Res. Inst. , Watertown, USA
Journal of Pharmacological Sciences 100 (suppl.1) 127-127, 2006.

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O3H3-4 The effects of GFP-tags on the ryanodine receptor type 1 / Ca2+ release channel in skeletal muscle

Hideto Oyamada1, Taku Kashiyama2, Takashi Murayama2, Takashi Makino1, Allen Paul D.3, Yasuo Ogawa2, Katsuji Oguchi1
1Dept. Pharmacol. , Showa Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Pharmacol. , Juntendo Univ. Sch. Med. , Tokyo, Japan,, 3Brigham and Women's Hospital, Boston, USA
Journal of Pharmacological Sciences 100 (suppl.1) 128-128, 2006.

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O3H3-5 Cell-cycle dependent regulation of small-conductance Ca2+ -activated K+ channel activity in Jurkat T -lymphocytes

Takashi Morimoto1, Susumu Ohya1, Hidetoshi Hayashi2, Katsuhiko Muraki1, Kikuo Onozaki2, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol. , Grad. Sch. of Pharmaceut. Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Dept. Mol. Health Sci. , Grad. Sch. of Pharmaceut. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 128-128, 2006.

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O3E4-1 Effect of ferulic acid on oxidative stress-induced memory deficits in mice

Takamasa Asanuma1, Takayoshi Mamiya1, Mitsuo Kise2, Yukihiko Ito2, Hiromichi Aoto2, Makoto Ukai1
1Dept. Chem. Pharmacol. Fac. Pharm. , Meijo Univ. , Aichi Nagoya , Japan,, 2Cent. Res. Labo. FANCL Co. , Ltd. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 128-128, 2006.

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O3E4-2 A free radical scavenger edar-avone ameliorates anxiety-related behavior after cerebral ischemia/reperfusion in rats

Taku Yamaguchi1, Jin Kakehata1, 2, Hiroko Togashi1, 3, Hiroshi Otani1, Machiko Matsumoto1, Mitsuhiro Yoshioka1
1Dept. Neuropharmacol. , Hokkaido Univ. Grad. Sch. Med. , Sapporo, Japan,, 2Dept. Anesthesiol. and Critical Care Med. , Hokkaido Univ. Grad. Sch. Med. , Sapporo, Japan,, 3Dept. Clin. Physiol. , Fac. Pharm. Sci. , Hlth. Sci. Univ. Hokkaido, Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 128-128, 2006.

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O3E4-3 Colivelin prolongs survival of an ALS model mouse

Tomohiro Chiba1, Yuichi Hashimoto1, Marina Yamada1, 2, Jumpei Sasabe1, 2, Kenzo Terashita1, Sadakazu Aiso2, Masaaki Matsuoka1, Ikuo Nishimoto1
1Dept. Pharmacol. , Keio Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Anatomy, Keio Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 129-129, 2006.

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O3E4-4 Suppressive effects of amyloid β (Aβ) fragments, Aβ 20-29 and Aβ 31-35 on Aβ -induced neurotoxicity

Kaori Kitagawa, Bo Wu, Nan-yan Zhang, Zheng-Mei Xiong, Chiyoko Inagaki
Dept. Pharmocol. , Kansai Med. Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 129-129, 2006.

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O3E4-5 CNTF receptor α /WSX-1 /gp130 complex-mediated neuroprotection from Alzheimer disease-related toxicity

Yuichi Hashimoto1, Megumi Kurita1, Kohsuke Kanekura1, Hiroaki Suzuki1, 2, Mikiro Nawa1, 2, Tomohiro Chiba1, Jumpei Sasabe1, 2, Marina Yamada1, 2, Sadakazu Aiso2, Ikuo Nishimoto1, Masaaki Matsuoka1
1Dept. Pharmacol. , KEIO Univ. , Sch. Med, Tokyo, Japan,, 2Dept. Anatomy, KEIO Univ. , Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 129-129, 2006.

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O3F4-1 Role of Ca2+ waves from pulmonary vein-left atrium junction in atrial arrythmoge-nesis

Hiroto Nishizawa1, Nagomi Kurebayashi2, Yuji Nakazato1, Hiroyuki Daida1
1Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan,, 2Dept. Pharmacol. , Juntendo Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 129-129, 2006.

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O3F4-2 Significance of the Ca2+ -induced inactivation of L-type Ca2+ channels in the phase 3 repolarization of cardiac action potential

Mitsuhiko Yamada
Dept. Mol. Pharmacol. Shinshu Univ. Sch. Med. , Nagano, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 130-130, 2006.

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O3F4-3 The beat-to-beat variability of ventricular repolarization as a marker for pre-dicting proarrhythmic potential of QT-pro-longing drugs, assessed in the chronic atrioventricular block dog model

Akira Takahara, Atsushi Sugiyama, Hiroshi Iwasaki, Yuji Nakamura, Keitaro Hashimoto
Dept. Pharmacol. , Univ. Yamanashi, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 130-130, 2006.

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O3F4-4 Molecular determinant of differences in the voltage-dependence between L-type Ca2+ channel Cav1.2 and Cav1.3

Hiroko Izumi-Nakaseko1, Kumi Sakairi2, Hidenori Ichijo2, Hiromichi Tsuru1, Satomi Adachi-Akahane1
1Dept. Pharmacol. , Fac. Med. , Toho Univ. , Tokyo, Japan,, 2Lab. Cell Signaling, Grad. Sch. Pharmaceutical Sci. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 130-130, 2006.

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O3F4-5 The intracellular mechanisms for the cardioprotective effects of SEA0400, a novel Na+-Ca2+ exchanger inhibitor

Iyuki Namekata1, Seri Kaeriyama1, Hideki Nakamura1, Toru Kawanishi2, Hikaru Tanaka1, Koki Shigenobu1
1Dept. Pharmacol. , Toho Univ. Sch. Pharmaceut. Sci, Chiba, Japan,, 2Div. Biol. Chem. Biol. , Natl. Inst. Health Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 130-130, 2006.

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O3G4-1 Leptin inhibits orexin-producing neurons through opening of KATP channel

Taizo Matsuki1, Akihiro Yamanaka1, 2, Yo Muraki2, Katsutoshi Goto2, Masashi Yanagisawa1, 3, Takeshi Sakurai1, 2
1ERATO Yanagisawa Orphan Receptor Project, JST. , Tokyo, Japan,, 2Dept. Pharmacol. , Inst. Basic Med. Sci. , Univ. Ibaraki, Japan,, 3HHMI and Dept. Mol. Gen. , Univ. Texas SW Med. Ctr. at Dallas, Texas, USA
Journal of Pharmacological Sciences 100 (suppl.1) 131-131, 2006.

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O3G4-2 Effect of lutein and pycnogenol on lipid peroxidation in porcine retinal homogenate

Takako Nakanishi1, Satoshi Yano1, Mariko Iwase1, Yuki Nishimura1, Naoki Uchida1, Katsuya Wada2, Hajime Yasuhara1
1Dept. Pharmacol. , Sch. Med. Showa Univ. , Tokyo, Japan,, 2Naturally Plus Co. , Ltd, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 131-131, 2006.

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O3G4-3 Roles of P13K in superoxide production and chemotaxis in FMLP-stimulated rat neutrophils

Yukio Azuma, Masanori Kashimata
Dept. Dental Pharmacol. , Asahi Univ. Sch. Dent. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 131-131, 2006.

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O3G4-4 Differentiation-inducing factors reduce both the protein and mRNA expression levels of cyclin D1 through the activation of glycogen synthase kinase-3β

Fumi Takahashi, Jun Mori, Tania Yasmin, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. , Fac. of Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 131-131, 2006.

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O3G4-5 Cytotoxicity of lidocaine - Necrosis associated with cell shrinkage -

Yumiko Nishimura, Kanna Horimoto, Masako Kobayashi, Yasuo Oyama
Lab, Cell Signaling, Fac. Integrated Arts & Sci. , Tokushima Univ. , Tokushima, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 132-132, 2006.

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O3H4-1 Role of Prokineticin 2 Signaling on the Neurogenesis of Adult Olfactory Bulb

Kwan. L. Ng, Jia-Da Li, Michelle. Y Cheng, Frances. M Leslie, Alex. G Lee, Qun-Yong Zhou
Department of Pharmacology, University of California, Irvine, USA
Journal of Pharmacological Sciences 100 (suppl.1) 132-132, 2006.

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O3H4-2 The vulval precursor cells of C. elegans supply Nertrin/UNC-6 for the proper axon guidance of HSN neurons

Taro Asakura1, Ken-ichi Ogura1, Yoshio Goshima1, 2
1Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. Grad. Sch. Med. , Yokohama, Japan,, 2JST. CREST. , Kawaguchi, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 132-132, 2006.

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O3H4-3 Opposite regulation of insulin receptor substrate-1/-2 by heat shock protein 90

Norie Yoshikawa, Toshihiko Yanagita, Shinya Satoh, Toyoaki Maruta, Takayuki Nemoto, Hiroki Yokoo, Hideyuki Kobayashi, Akihiko Wada
Dept. Pharmacol. , Miyazaki Med. Coll. , Univ. Miyazaki, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 132-132, 2006.

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O3H4-4 Dimerization and quality control of insulin-like growth factor-I receptor by heat shock protein 90

Toshihiko Yanagita, Tomokazu Saitoh, Norie Yoshikawa, Shinya Satoh, Hiroki Yokoo, Hideyuki Kobayashi, Takayuki Nemoto, Toyoaki Maruta, Akihiko Wada
Dept. Pharmacol. , Miyazaki Med. Coll. , Univ. Miyazaki, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 133-133, 2006.

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O3H4-5 Attenuated phosphorylation of heat shock protein 27 is correlated with tumor progression in patients with hepato-cellular carcinoma

Eisuke Yasuda1, 2, Takashi Kumada3, Shinji Takai1, Akira Ishisaki1, Takahiro Noda1, 2, Rie Nishiwaki1, Naoki Yoshimi4, Hidenori Toyoda3, Yuji Kaneoka5, Akihiro Yamaguchi5, Masayuki Niwa1, Osamu Kozawa1
1Dept. Pharmacol. Gifu Univ. Graduate Sch. Med. , Gifu, Japan,, 2Dept. Med. Technol. Ogaki Municipal. Hosp. , Gifu, Japan,, 3Dept. Gastroenterol. Ogaki Municipal. Hosp. , Gifu, Japan,, 4Dept. Tumor Pathol. Ryukyu. Univ. Sch. Med. , Okinawa. Japan. ,, 5Dept. Surgery. Ogaki Municipal. Hosp. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 133-133, 2006.

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O3H4-6 IFN-γ potentiates anti-cancer effects of hyperthermia and chemotherapeu-tics through Hsp27 down-regulation

Mariko Oba1, Tsuyoshi Shuto1, Shuichiro Yano1, Takashi Furuta1, MaryAnn Suico1, Tsukasa Okiyoneda1, Akiko Uehara2, Hirofumi Kai1
1Dept. Mol. Med. , Fac. Med. Pharm. , Kumamoto Univ. , Kumamoto, Japan,, 2Dept. Microbiol. Immunol. , Grad. Sch. Dent. , Tohoku Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.1) 133-133, 2006.

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