Journal of Pharmacological Sciences 100巻 suppl.2号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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P1K-01 Natural drug extracts for a nutritive-tonic drink, promote induction of long-term potentiation in rat dentate gyrus in vivo

Yasuko Sakata, Tomohiro Ohtakara, Kumiko Ishige, Yoshihisa Ito
Dept. of Pharmacol. , Coll. of Pharm. , Nihon Univ. , Funabashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 136-136, 2006.

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P1K-02 Presynaptic I1-Imidazoline receptors reduce GABAergic synaptic transmission in the striatum

Yurika Kino, Motoko Honda, Hideki Ono, Mitsuo Tanabe
Dept. CNS Pharmacol. , Grad Sch Pharm Sci, Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 136-136, 2006.

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P1K-03 Morphine regulates excitatory neurotransmission evoked by glutamate in the thalamus

Keisuke Hashimoto1, Minoru Narita1, Taku Amano2, Mayumi Miyatake1, Norio Sakai2, Tsutomu Suzuki1
1Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. , Tokyo, Japan,, 2Dept. Mol. Pharmacol. Neurosci. , Grad. Sch. Biomed. Sci. , Hiroshima Univ. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 136-136, 2006.

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P1K-04 Functional suppression of neu-ronal nicotinic acetylcholine receptors by dehydroepiandrosterone and its sulfate ester

Kenzo Kudo, Eiichi Tachikawa, Yukiko Kondo, Kenzo Mizuma, Eiichi Taira
Dept. Pharmacol. , Sch. Med. , Iwate Medical Univ. , Morioka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 136-136, 2006.

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P1K-05 Effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, on cate-cholamine synthesis in cultured bovine adrenal medullary cells

Koji Shinkai1, Yumiko Toyohira2, Reiji Yoshimura1, Susumu Ueno2, Masato Tsutsui2, Minhui Liu2, Jun Nakamura1, Nobuyuki Yanagihara2
1Dept. Psychiatry, Univ. of Occup. & Environ. Health, Sch. Med. , Kitakyushu, Japan,, 2Dept. Pharmacol. , Univ. of Occup. & Environ. Health, Sch. Med. , Kitakyushu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 137-137, 2006.

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P1K-06 Pharmacological characterization of functional P2 receptors in cultured rat per-icytes; regulation of contractile responses

Kayoko Fujishita1, Koji Sueishi1, 2, Yasufumi Kataoka2, Kazuhide Inoue3, Schuichi Koizumi1
1Div. Pharmacol. , Natl. Inst. Hlth. Sci. , Tokyo, Japan,, 2Dept. Pharmaceut. Care & Health Sci. , Fac. Pharmaceut. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 3Dept. Mol. Sys. Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Kyusyu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 137-137, 2006.

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P1K-07 The relationship between nicotinic acetylcholine receptors and the hemodynamics changes of spontaneously hypertensive rats during chronic cigarette smoke

Kaoru Kubo1, Toshikatsu Nakashima2
1Lab. Animal. Res. Ctr. , Nara Med. Univ. Sch. Med. , Nara, Japan,, 2Faculty of Health Sci. , Kio Univ. , Nara, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 137-137, 2006.

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P1K-08 Comparison of the inhibitory effects of donepezil and cloperastine on the G-protein coupled inwardly rectifying K+ (GIRK) channel-activated currents in rat dor-sal raphe neurons

Kayo Hashitani, Tetsuya Shirasaki, Fumio Soeda, Kazuo Takahama
Dept. Environ. & Mol. Health Sci. , Grad. Sch. Pharm. Sci. , Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 137-137, 2006.

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P1K-09 A novel in vitro screening method for sedative and non-sedative histamine H1 receptor antagonists by use of an intact cell binding

Shigeru Hishinuma, Masaki Saito
Dept. Pharmacodyn. , Meiji Pharm. Univ. , Kiyose, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 138-138, 2006.

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P1K-10 Involvement of Ca2+ -dependent mechanisms in down-regulation of Gq, Protein-coupled/Ca2+ -mobilizing histamine H1 receptors

Yusuke Kobayashi, Shigeru Hishinuma, Masaki Saito
Dept. Pharmacodyn. , Meiji Pharm. Univ. , Kiyose, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 138-138, 2006.

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P1K-11 Visualization of synaptic transmission by optical glutamate imaging

Hirokazu Sakamoto, Kenzo Hirose
Dept. Cell Physiol. , Nagoya Univ. Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 138-138, 2006.

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P1K-12 Effects of cloperastine on the 8-OH-DPAT-induced single K+ channel currents

Michitaka Shiozuka, Tetsuya Shirasaki, Fumio Soeda, Kazuo Takahama
Dept. Environ. & Molec. Health Sci, Grad. Sch. Pharm. Sci. , Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 138-138, 2006.

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P1K-13 Facilitated glycine release by metabolic disturbances in the motoneurons

Yu Kono1, 2, Eiji Shigetomi2, Kiyoharu Inoue1, Fusao Kato2
1Dept. Neurol. , Jkiei Univ. Sch. Med, Tokyo, Japan,, 2Lab. Neurophsiol. , Jkiei Univ. Sch. Med, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 139-139, 2006.

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P1K-14 Self-rewriting networks: Ongoing modification of functional connectivity in hip-pocampal CA3 networks

Masako Tsukamoto, Takuya Sasaki, Norio Matsuki, Yuji Ikegaya
Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 139-139, 2006.

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P1K-15 Serotonin 5-HT1A receptor agonist properties of several antipsychotics deter-mined by [35S]GTP γ S binding assay in rat hippocampal membranes

Yuji Odagaki, Ryoichi Toyoshima
Dept. Psychiat. , Saitama Med. Sch. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 139-139, 2006.

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P1K-16 Effects of nicotine on neurogenesis and plasticity in hippocampus

Maiko Kitagawa, Akiko S Shingo, Shozo Kito
Hyogo Univ. Sch. of Health Sci. Lab of Neurosci. , Hyogo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 139-139, 2006.

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P1K-17 Carboxy terminal region differently regulates the functional expression of human norepinephrine transporter splice variants

Chiharu Sogawa1, Norio Sogawa1, Kei Kumagai2, Katsuya Morita2, Toshihiro Dohi2, Kenji Onodera1, Shigeo Kitayama1
1Dept. Dent. Pharmacol. , Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. , Okayama, Japan,, 2Dept. Dent. Pharmacol. , Hiroshima Univ. Grad. Sch. Biomed. Sci. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 140-140, 2006.

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P1K-18 Long-term administration of citalopram decreases the extracellular noradrenaline levels with remaining the function of α2-adrenoceptors in rat brain

Yukie Kawahara1, Fumi Kaneko1, Hiroshi Kawahara2, Masatoshi Tanaka1
1Dept. Pharmacol. , Kurume Univ. Sch. Med. , Kurume, Japan,, 2Dept. Dental Anesthesiology, Kyushu Dental College, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 140-140, 2006.

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P1K-19 The central neurotoxicity of 1-bromopropane (1-BP), a substitute for chloroflu-orocarbons: Studies on the effects caused by direct and subchronic exposure to 1-BP on hippocampal function

Susumu Ueno1, Yukiko Fueta2, Toru Ishidao4, Yasuhiro Yoshida3, Masato Tsutsui1, Yumiko Toyohira1, Hajime Hori4, Nobuyuki Yanagihara1
1Dept. Pharmacol. , Univ. Occup. & Environ. Hlth. , Japan, Sch. Med. , Kitakyushu, Japan,, 2Dept. Med. Technol. , Univ. Occup. & Environ. Hlth. , Japan, Sch. Hlth. Sci. , Kitakyushu, Japan,, 3Dept. Immunol. , Occup. & Environ. Hlth. , Japan, Sch. Med. , Kitakyushu, Japan,, 4Dept. Environ. Management. , Univ. Occup. & Environ. Hlth. , Japan, Sch. Hlth. Sci. , Kitakyushu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 140-140, 2006.

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P1K-20 Effects of benzodiazepine hyp-notics and antihistamines on the sleep-wake cycle in sleep-disturbed rats

Shin Tokunaga1, Kazuaki Shinomiya2, Asae Ohmori1, Yasuhiro Takeda1, Masahiro Hirase1, Yoko Fujii1, Chiaki Kamei1
1Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan,, 2Adv. Res. Inst. for Biosci. , Waseda Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 140-140, 2006.

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P1K-21 Pharmacological profiles of a novel potent serotonin 5-HT2C receptor antagonist FR260010 in animal models of anxiety

Katsuya Harada, Masaki Aota, Tatsuo Inoue, Ritsuko Matsuda, Takuma Mihara, Takayuki Yamaji, Nobuya Matsuoka, Seitaro Mutoh
Pharmacology Research Labs. , Astellas Pharma Inc. , Tsukuba, Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 141-141, 2006.

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P1K-22 Effects of systemic psilocin on serotonin release in rat brain

Nobuyuki Katagiri1, Kenji Abe2, Mitsune Yamaguchi3, Toshiaki Saitoh4, Yoshie Horiguchi4, Iku Utsunomiya1, Keiko Hoshi1, Kyoji Taguchi1
1Dept. Phrmacothera. , Shoyaku Univ. , Tokyo, Japan,, 2Dept. Pharmacol. , Ohu. Univ. , Fukusima Japan,, 3Dept. Hygienic chem. , Shoyaku Univ. , Tokyo, Japan,, 4Dept. Med chem. , Shoyaku Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 141-141, 2006.

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P1K-23 Effect of coadministration of sulpiride and fluvoxamine on in vivo acetyl-choline release in rat prefrontal cortex

Maiko Sato1, Yukio Ago2, Toshiya Harasawa1, Soichi Itoh1, Akemichi Baba2, Toshio Matsuda1
1Lab. Medicinal Pharmacol. , Grad. Sch. Pharm. Sci. , Osaka Univ. , Osaka, Japan,, 2Lab. Mol. Neuropharmacol. , Grad. Sch. Pharm. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 141-141, 2006.

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P1K-24 High performance fluorescent glu-tamate probes for visualization of synaptic transmission

Sho Iinuma, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose
Dept. Cell Physiol. , Nagoya Univ. Sch. Med, Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 141-141, 2006.

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P1K-25 Sevoflurane excites the locus coeruleus neurons

Yutaka Yasui1, Eiji Masaki3, Fusao Kato2
1Dept. Anesthesiol. , Jikei. Univ. Sch. Med. , Tokyo, Japan,, 2Lab. Neurophysiol. , Jikei Univ. Sch. Med. , Tokyo, Japan,, 3Dept. Anesthesiol. Saitama Med. Sch. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 142-142, 2006.

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P1K-26 Decreased activity of brain neprilysin causes cognitive impairment through an increase in synapse-associated Aβ oligomers

Nobuhisa Iwata1, Akihiro Mouri2, Hideko Kokubo3, Shu-Ming Huang1, Ryuichi Nakajima1, Takahiro Suemoto1, Makoto Higuchi1, 4, Matthias Staufenbiel5, Yukihiro Noda6, Haruyasu Yamaguchi3, Toshitaka Nabeshima2, Takaomi C. Saido1
1Lab. for Proteolytic Neurosci. , RIKEN BSI, Saitama, Japan,, 2Dept. Neuropsychopharmacol. Hospital Pharm. , Nagoya Univ. Sch. Med. , Aichi, Japan,, 3Gunma Univ. Sch. of Health Sci. , Gunma, Japan,, 4National Institute of Radiological Sciences, Chiba, Japan,, 5Nervous System Res. , Novartis Pharma A. G. , Basel, Switzerland,, 6Facul. Pharm. , Meijo University, Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 142-142, 2006.

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P1K-27 Impairment of auditory-cued fear conditioning in rats with permanent occlusion of bilateral common carotid arteries

Masayasu Takahashi, Shinya Takami, Akira Nagakura, Keni Ni, Nobuya Matsuoka
Pharmacology Research Labs. , Astellas Pharma Inc. , Tsukuba, Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 142-142, 2006.

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P1K-28 Cognitive dysfunction induced by sequential injection of amyloid β and ibote-nate into the bilateral hippocampus; protection by memantine and MK-801

Shizuo Nakamura, Norihito Murayama, Takafumi Noshita, Ryoko Ogino, Tomochika Ohno
Daiichi Asubio Pharma Co. , Ltd. , Biomed. Res. Lab. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 142-142, 2006.

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P1K-29 Effects of antidepressants in the forced swimming test: Studies on sex differences in mice

Sachiko Furutani1, Yumi Sugimoto1, Yoshinobu Kajiwara1, Yuko Taki2, Kazufumi Hirano2, Shizuo Yamada2, Jun Yamada1
1Dept. Pharmacol. , Kobe Pharm. Univ. , Kobe, Japan,, 2Dept. Biopharm. Sci. , Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 143-143, 2006.

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P1K-30 Mice strain differences in forced swimmint test: DBA/2 mice are useful animal model

Yumi Sugimoto1, Sachiko Furutani1, Yoshinobu Kajiwara1, Kazufumi Hirano2, Shizuo Yamada2, Jun Yamada1
1Dept. Pharmacol. , Kobe Pharm. Univ. , Kobe, Japan,, 2Dept. Biopharm. Sci. , Univ. Shizuoka, Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 143-143, 2006.

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P1K-31 Effect of postnatal noise stress on emotional and anxiety-related behavior and spatial learning in juvenile mice

Noriko Tamura, Kohji Tokumo, Takao Hirai, Hiroaki Nishio
Dept. Mol. Pharmacol. Facul. Pharm. Pharmaceut. Sci. Fukuyama Univ. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 143-143, 2006.

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P1K-32 Novel PET probes for in vivo imaging of tau pathology in Alzheimer's disease

Satoshi Ito1, Nobuyuki Okamura1, Motohisa Katou1, Shozo Furumoto2, Hiroyasu Akatsu3, Takayuki Yamamoto3, Tohru Sawada4, Hiroyuki Arai5, Yukitsuka Kudo2, Kazuhiko Yanai1
1Dept. Pharmacol. , Tohoku Univ. Sch. Med, Sendai, Japan,, 2Tohoku Univ. Biomed. Engineer. Res. Org. (TUBERO), Sendai, Japan,, 3Cyouju. Med. Inst. Fukushimura Hosp. , Toyohashi, Japan,, 4BF Res. Inst. , Osaka, Japan,, 5Dept. Geriat. Complement. Med. , Tohoku Univ. Sch. Med, Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 143-143, 2006.

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P1K-33 Intereukin-1 receptor antagonist effects on neural and behavioral development in mice

Noriko Tsuda1, Yoichiro Iwakura2, Hiroyuki Nawa1
1Dept. of Molecular Neurobiology, Brain Research Inst. , Univ. of Niigata, Niigata, Japan,, 2Lab. Cell Biology, Center for Experimental Medicine, Inst. Med. Sci. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 144-144, 2006.

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P1K-34 The behavior-pharmacological research on the usefulness of flunarizine in the Alternating Hemiplegia of Childhood

Yoshiaki Matsumoto1, 2, Ayano Matsushima1
1Div. Pharmacol. , Deg. Cour. Sch-Nur. , Kyushu Women's Jr. Col. , Kitakyushu, Japan,, 2Div. Pharmacol. , Dept. Sch-Nur. , Kyushu Women's Jr. Col. , Kitakyushu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 144-144, 2006.

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P1K-35 Alterations in cognitive function in prepubertal mice with protein malnutrition

Osamu Nakagawasai1, Shoko Sato1, Satoru Mitazaki1, Takeharu Nakajima1, Koichi Tan-No1, Fukie Niijima1, Yuichiro Arai2, Hitoshi Murakami3, Kazunori Mawatari3, Takeshi Tadano1
1Dept. Pharmacol. , Tohoku Pharmaceu. Univ. , Sendai, Japan,, 2Dep. Pharmacol. , Showa Univ. Sch. Med. , Tokyo, Japan,, 3Amino Sci. Lab. , Ajinomoto Co. , Inc, Kawasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 144-144, 2006.

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P1K-36 An animal model of depression: Recoveries from reduction of 5-HT release in the amygdala and disturbance of circadian rhythm of activity induced by the chronic dexamethasone infusion in rats

Norifumi Shimizu, Nobuo Izumo, Minehiro Moriyama, Shoko Yasuoka, Yukiko Kuriyama, Shigenori Watanabe, Chiaki Hara
Dept. Pharmacol. , Daiichi Univ. Coll. Pharmaceut. Sci. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 144-144, 2006.

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P1K-37 Partial reversal of ketanserin on prepulse inhibition (PPI) deficits in a neu-rodevelopmental model of schizophrenia

Satoru Mitazaki, Osamu Nakagawasai, Koichi Tan-No, Fukie Niijima, Takeshi Tadano
Dept. Phamracol. , Tohoku Pharmaceu. Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 145-145, 2006.

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P1K-38 Influences of stress on the hip-pocampal synaptic function in the freely moving rat

Riki Hirata1, Hiroko Togashi1, 2, Machiko Matsumoto1, Taku Yamaguchi1, Hiroyo Koseki1, 3, Mitsuhiro Yoshioka1
1Dept of Neuropharmacol, Hokkaido Univ Graduate Sch of Med, Sapporo, Japan,, 2Dept, Clin Physiol, Facul. Pharm. Sci. , Hlth. Sci. Univ. Hokkaido, Hokkaido, Japan,, 3Dept. Dental Anesthesiol, Grad. Sch. Dental Med. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 145-145, 2006.

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P1K-39 Behavioral effects of isatin, an endogenous monoamine oxidase inhibitor, in a rat model of attention-deficit/hyperactivity disorder

Chiho Kurumazuka1, Kosei Ohno1, Mutsuko Terado1, Naoya Hamaue2, Ken-ichi Ueno3, Taku Yamaguchi3, Mitsuhiro Yoshioka3, Hiroko Togashi1
1Dept. Clin. Physiol. , Fac. of Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 2Dept. Pharmacol. , Fac. of Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 3Dept. Neuropharmacol. , Grad. Sch. Med. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 145-145, 2006.

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P1K-40 Behavioral effects of the early postnatal stress on emotional expressions in male and female rats

Hirokazu Matsuzaki1, Machiko Matsumoto2, Taku Yamaguchi2, Kasane Higuchi3, Kosei Ohno1, Mutsuko Terado1, Mitsuhiro Yoshioka2, Hiroko Togashi1
1Dept. Clin. Physiol. , Fac. of Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 2Dept. Neuropharmacol. , Grad. Sch. Med. , Hokkaido Univ. , Sapporo, Japan,, 3Dept. Oral Function Sci. , Grad. Sch. Med. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 145-145, 2006.

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P1K-41 Effects of methylphenidate on hyperemotional behaviors in olfactory bulbectomized mice in the hole-board test

Noritaka Hirose1, Akiyoshi Saitoh1, Mitsuhiko Yamada2, Junzo Kamei1
1Dept. Pathophysiol. Ther. , Sch. Pharm. Pharm. Sci. , Hoshi Univ. , Tokyo, Japan,, 2Dept. Psychogeriatr. , NINH. , NCNP. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 146-146, 2006.

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P1K-42 Involvement of BDNF in long-lasting antidepressant-like effect of electrocon-vulsive stimuli in rats forced swim test

Bingjin Li1, Katsuya Suemaru2, Ranji Cui1, Hiroaki Araki2
1Clin. Physiol. Funct. Stud. Ehime Univ. Grad, Sch. Med, Toon, Ehime, Japan,, 2Div. Pharmacy, Ehime Univ. Hosp. , Ehime, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 146-146, 2006.

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P1K-43 Repeat dexamethasone treatment induced the dysfunction of HPA axis depending on the dosing-time

Kentarou Ushijima1, Fumie Koresawa1, Kazuya Ninomiya1, Yuki Sato1, Hideto To1, Shigehiro Ohdo2, Shun Higuchi1
1Dept. Clin. Pharmacokinet. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan,, 2Dept. Pharmaceutics. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 146-146, 2006.

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P1K-44 Discrete metabolic changes in the STOP gene knock out mice, a model of schizophrenia

Ryosuke Hanaya1, 2, Koning Estelle2, Ferrandon Arielle2, Schweitzer Annie3, Andrieux Annie3, Nehlig Astrid2
1Dept. Neurosurg. , Hiroshima Univ. Grad. Sch. Biomed. Sci. , Hiroshima, Japan,, 2INSERM U, rue Humann, Strasbourg, France,, 3INSERM U, Grenoble, France
Journal of Pharmacological Sciences 100 (suppl.2) 146-146, 2006.

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P1K-45 Effect of memantine, a therapeutic drug for Alzheimer disease, and MK-801 on neuronal and glial activity in rat brain regions

Takeshi Kato1, Mohammad Arif1, Mahiuddin Ahmed2
1Lab. Natural Inform. Sci. , Grad. Sch. Int. Sci. , Yokohama City University, Yokohama, Japan,, 2Bioelectro Anal. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 147-147, 2006.

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P1K-46 Raloxifene and EGb761 suppress stress-induced memory impairment in ovariectomized rats

Yuki Hoshina1, Kazuhiro Takuma1, Ai Matsuo1, Yukiko Himeno1, Sawako Arai1, Hiroyuki Kamei1, Taku Nagai1, Koji Koike2, Masaki Inoue2, Kiyofumi Yamada1
1Lab. Neuropsychopharmacol. , Div. Life Sci. , Grad. Sch. Nat. Sci. Technol. , Kanazawa Univ. , Kanazawa, Japan,, 2Dept. Obstet. Gynecol. , Grad. Sch. Med. Sci. , Kanazawa Univ. , Kanazawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 147-147, 2006.

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P1K-47 Rosmarinic acid protects against memory impairments induced by acute i.c.v. injection of Aβ25-35

Tursun Alkam1, Atsumi Nitta1, Akio Itoh1, Hiroyuki Mizoguchi1, Hiroko Tsunekawa1, Akihiro Mouri1, Yukihiro Noda1, 2, Toshitaka Nabeshima1
1Dept. Neuropsychopharmacol. hospital pharm. , Nagoya. Univ. Grad. Med. , Nagoya, Japan,, 2Dept. Clinical Sci, Facul. Pharm. , Meijo Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 147-147, 2006.

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P1K-48 Behavioral and neurochemical studies on a new redent model of ADHD

Kito Shozo, Yuka Yamamoto, Mie Unohara, Maiko Kitagawa, Izumi Yamashita, Akiko S Shingo
Hyogo Univ. Sch. of Health Sci. Lab of Neurosci. , Hyogo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 147-147, 2006.

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P1K-49 Anti-immobility effect of fluvox-amine depended on the 24-hr rhythm of serotonin transporter

Yuki Sato1, Kentarou Ushijima1, Hiromi Sakaguchi1, Kazuya Ninomiya1, Fumie Koresawa1, Hideto To1, Shigehiro Ohdo2, Shun Higuchi1
1Dept. Clin. Pharmacokinet. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan,, 2Dept. Pharmaceutics. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 148-148, 2006.

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P1K-50 Time-dependent alteration of responses of clock genes in PVN for gluco-corticoids

Kazuya Ninomiya1, Kentarou Ushijima1, Fumie Koresawa1, Yuki Sato1, Hideto To1, Shigehiro Ohdo2, Shun Higuchi1
1Dept. Clin. Pharmacokinet. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan,, 2Dept. Pharmaceutics. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 148-148, 2006.

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P1K-51 Behavioral and neurochemical alterations in sleep deprived adolescent rats

AJing Xu
Dept. Pharmacol. , Tohoku Univ. Sch. Med. , Tohoku, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 148-148, 2006.

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P1K-52 Effects of (Z)-3-hexenol, a major component of green odor, on anxiety-related behavior of the mouse in an elevated plus-maze test and biogenic amines and their metabolites in the brain

Kohji Tokumo, Noriko Tamura, Takao Hirai, Hiroaki Nishio
Dept. Mol. Pharmacol. Facul. Pharm. Pharmaceut. Sci. Fukuyama Univ. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 148-148, 2006.

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P1K-53 Influence of stress-loaded conditions on the effects of nonylphenol in exploratory and emotional behaviors in mice

Koumei Moriguchi, Kimihiro Yamashita
Dept. Environ. Conserv. , Fac. Environ. Stud. , Nagasaki Univ. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 149-149, 2006.

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P1K-54 Change of AP-1 in brain of dexamethasone infusion rats

Nobuo Izumo, Norifumi Simizu, Minehiro Moriyama, Syouko Yasuoka, Yukiko Kuriyama, Shigenori Watanabe, Chiaki Hara
Dept. Pharmacol. , Daiiti Univ. College of Pharmac. Sci, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 149-149, 2006.

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P1K-55 Mechanism for the imipramine-induced seizures in amygdala-kindled rats

Jun Ago, Naotaka Matsumoto, Takashi Ishikawa, Yoko Fujii, Chiaki Kamei
Dept. Med. Pharmacol. Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 149-149, 2006.

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P1K-56 Tissue type plasminogen activator facilitates NMDA-receptor-mediated retinal apoptosis

Masayuki Niwa1, 2, Masako Kumada3, Akira Hara4, Hiroyuki Matsuno2, Hideki Mori4, Osamu Matsuo5, Tetsuya Yamamoto3, Osamu Kozawa2
1Medical Education Development Center, Gifu Univ. Sch. Med. , Gifu, Japan,, 2Dept. Pharmacol. , Gifu Univ. Sch. Med. , Gifu , Japan,, 3Dept. Ophtalmol. , Gifu Univ. Sch. Med. , Gifu, Japan,, 4Dept. TumorPathol. , Gifu Univ. Sch. Med. , Gifu, Japan,, 5Dept. Physiol. , Kinki Univ. Sch. Med. , Osaka -Sayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 149-149, 2006.

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P1K-57 Involvement of endoplasmic retic-ulum stress in retinal cell death

Masamitsu Shimazawa1, Yuta Inokuchi1, Masayuki Miura2, Hideaki Hara1
1Dept. Biofunct. Mol. , Gifu Pharmaceut. Univ. , Gifu, Japan,, 2Dept. Genet. , Grad. Sch. Pharmaceut. Sci. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 150-150, 2006.

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P1K-58 The role of Na+/Ca2+ exchanger in retinal cell death induced by N-methyl-D-aspartate

Yuta Inokuchi1, Masamitsu Simazawa1, Issei Komuro2, Toshio Matsuda3, Akemichi Baba4, Takahiro Iwamoto5, Hideaki Hara1
1Dept. Biofunct. Mol. , Gifu Pharmaceut. Univ. , Gifu, Japan,, 2Dept. Cardiovasc. , Chiba Univ. Grad. Sch. Med. , Chiba, Japan,, 3Lab. Medicinal Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 4Lab. Mol. Neuropharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 5Dept. Pharmacol. , Grad. Sch. Med. Sci. , Fukuoka Univ, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 150-150, 2006.

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P1K-59 Cilnidipine reduces neuronal cell death induced by intravitreous injection of NMDA in the rat retina

Takako Kawakami, Maki Saito, Tsutomu Nakahara, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol. , Kitasato Univ. Sch. pharm. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 150-150, 2006.

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P1K-60 All-trans retinoic acid reduces neuronal cell death induced by intravitreous injection of NMDA in the rat retina

Masahide Hiraiwa1, Maki Saito1, Tsutomu Nakahara1, Yoji Sato2, Taku Nagao2, Kenji Sakamoto1, Kunio Ishii1
1Dept. Mol. Pharmacol. , Kitasato Univ. Sch. Pharm. Sci. , Tokyo, Japan,, 2NIHS, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 150-150, 2006.

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P1K-61 Neuroprotective effects of sirtuin-activating polyphenols in mesencephalic slice cultures

Mitsugi Okawara, Hiroshi Katsuki, Haruki Shibata, Toshiaki Kume, Akinori Akaike
Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 151-151, 2006.

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P1K-62 Nitric oxide protects microglia from hydrogen peroxide-induced apoptosis

Yoshitaka Kouno, Yasuhiro Yoshioka, Tatsuya Kitao, Akiko Yamamuro, Sadaaki Maeda
Dept. Pharmacotherap. , Faculty Pharmaceut. Sci. , Setsunan Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 151-151, 2006.

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P1K-63 Characterization of 4-hydrox-ynonenal-induced cell death using various neuroprotective compounds in cerebellar granule neurons

Motoki Arakawa, Kumiko Ishige, Yoshihisa Ito
Dept. of Pharmacol. , Coll. of Pharm. , Nihon Univ. , Funabashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 151-151, 2006.

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P1K-64 Distinct caspase is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells

Tetsuro Oda, Kumiko Ishige, Motoki Arakawa, Yoshihisa Ito
Dept. of Pharmacol. , Coll. of Pharm. , Nihon Univ. , Funabashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 151-151, 2006.

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P1K-65 Involvement of caspases and DNase II in trimethyltin-induced damage of cortical neurons

Keiichi Seko, Koichi Kawada, Chie Sugiyama, Masanori Yoneyama, Kiyokazu Ogita
Dept. pharmacol. , Setsunan Unive. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 152-152, 2006.

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P1K-66 Zinc neurotoxicity and its relation-ship with calcium homeostasis

Keiko Konoha, Yutaka Sadakane, Masahiro Kawahara
Dept. Anal. Chem. , Sch. Pharmaceut. Sci. , Kyushu Univ. of Health and Welfare, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 152-152, 2006.

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P1K-67 Endoplasmic reticulum stress induces apoptosis through the activation of caspase-4 and -9 in human neuroblastoma SH-SY5Y cells

Akiko Yamamuro, Takashi Kishino, Yasuhiro Yoshioka, Sadaaki Maeda
Dept. Pharmacotherap. , Setsunan Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 152-152, 2006.

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P1K-68 Counteraction via P2Y1 receptor activation against the oxidative-stress-evoked death-inducing signaling in astrocytes

Youichi Shinozaki1, Schuichi Koizumi1, Kazuhide Inoue2
1Div. Pharmacol. , Natl. Inst. Hith. Sci. , Tokyo, Japan,, 2Dept. Mol. Sys. Pharmacol. , Grad. Sch. Pharmaceut. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 152-152, 2006.

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P1K-69 Down-regulation of CI- pump CIP55 subunit induced enhancement of glutamate neurotoxicity in cultured rat hippocampal neurons

Tiesong Li, Kaori Kitagawa, Nan-yan Zhang, Zheng-mei Xiong, Chiyoko Inagaki
Dept. Pharmacol. , Kansai Med. Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 153-153, 2006.

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P1K-70 In vitro embryotoxicity assays by using mouse embryonic stem cells

Mayu Murabe, Akito Tanoue
Dept. Pharmacol. , Natl. Res. Inst. Child Health Develop. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 153-153, 2006.

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P1K-71 Facilitation of H2O2-induced A172 human glioblastoma cell death by stable expression of oxidative stress-sensitive TRPM2 channels

Akinori Oyama, Masakazu Ishii, Shunichi Shimizu, Yuji Kiuchi
Dept. Pathophysiol. , Sch. Pharm. , Sci. , Showa Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 153-153, 2006.

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P1K-72 Convulsions induced by glutamine synthetase inhibitors were inhibited by NMDA receptor antagonists and an nNOS inhibitor

Nobuko Matsumura, Kazue Utsumi, Mami Ishizaka, Toshio Nakaki
Dept. Pharmacol. , Teikyo Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 153-153, 2006.

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P1K-73 Neuroprotective effects of isoflavones as selective estrogen receptor modulators

Akiko S Shingo, Izumi Yamashita, Mie Unohara, Maiko Kitagawa, Yuka Yamamoto, Shozo Kito
Hyogo Univ. Sch. of Health Sci. Lab of Neurosci. , Hyogo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 154-154, 2006.

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P1K-74 High mobility group box protrein-1 enhances amyloid-β neurotoxicity

Kazuyuki Takata1, Yoshihisa Kitamura1, Shun Shimohama2, Takashi Taniguchi1
1Dept. Neurobiol. , 21st Century COE Program, Kyoto Pharm. Univ. , Kyoto, Japan,, 2Dept. Neurol. , Grad. Sch. Med. , Kyoto Univ. , Kyoyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 154-154, 2006.

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P1K-75 Role of prokineticin-2 on kainic acid-induced excitotoxicity in mouse hip-pocampus

Naotaka Horiguchi1, Ken Koda1, Yutaka Koyama1, Yukio Ago2, Norihito Shintani2, Akemichi Baba2, Toshio Matsuda1
1Lab. Med. Pharmacol. , Grad. Sch. Pharma. Sci. , Osaka Univ. , Osaka, Japan,, 2Lab. Mol. Neuropharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 154-154, 2006.

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P1K-76 Characterization of neurotoxicity induced by amyloid β-peptide and tuni-camycin in organotypic hippocampal slice cultures

Toru Imai1, Yasuhiro Kosuge1, 2, Kumiko Ishige1, Yoshihisa Ito1
1Dept. of Pharmacol. , Coll, of Pharm. , Nihon Univ. , Funabashi, Japan,, 2Dept. of Pharmacol. , Tokyo Dental Coll. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 154-154, 2006.

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P1K-77 Overexpression of megsin induces neuronal degeneration: Role of the endoplasmic reticulum (ER) stress

Katsura Takano1, Yasuko Kitao2, Reiko Inagi3, Takashi Momoi4, Tomohiro Matsuyama5, Toshio Miyata3, Yukio Yoneda1, Hiroyuki Iso5, Osamu Hori2, Satoshi Ogawa2
1Lab. Mol. Pharmacol. , Kanazawa Univ. Grad. Sch. Nat. Sci. Tech. , Ishikawa, Japan,, 2Kanazawa Univ. Grad. Sch. Med. , Ishikawa, Japan,, 3Ins. Med. Sci. , Tokai Univ. , Kanagawa, Japan,, 4Nat. Ins. Neurosci. , Tokyo, Japan,, 5Hyogo Med. College, Hyogo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 155-155, 2006.

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P1K-78 The role of Na+/Ca2+ exchanger (NCX) in seizure of mice

Erina Kaneko1, Ryo Saito1, Yasutoshi Hirabara1, Kenji Honda1, Toshio Matsuda2, Akemichi Baba3, Takahiro Iwamoto4, Yukio Takano1
1Dept. Physiol. and. Pharmacol. Sci. , Fac. Pharmac. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 2Lab. Med. Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 3Lab. Med. Neuropharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 4Dept. Pharmacol. , Sci. , Sch. Med. , Fukuoka Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 155-155, 2006.

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P1K-79 Neuroprotective effects of dopamine D2 agonists on 6-hydroxy-dopamine-induced ER stress in the mouse brain

Ken-ichi Tanaka1, Hiroya Ogo1, Kaoruko Fukuhara1, Masato Asanuma2, Norio Ogawa2
1Dept. Clin. Pharm. , Shujitsu Univ. Sch. Pharm. , Okayama, Japan,, 2Dept. Brain Sci. , Okayama Univ. Grad. Sch. Med. , Dent. , Pharm. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 155-155, 2006.

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P1K-80 Enhancement of sympathetic contraction by Sr-90 exposure in rat tail artery

Kazuyoshi Kurahashi, Hideo Miyatake, Yasuhito Isozumi
Pharmacol Div, RI Ctr, Kyoto University, Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 155-155, 2006.

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P1K-81 Effect of nicorandil on sympathetic neurotransmission in SHR/NDmcr-cp

Ami Tei1, Masaki Tabuchi2, Namie Nejime1, Yoko Kubota1, Satomi Kagota1, Hideaki Higashino2, Michio Hashimoto3
1Dept. Pharmacol. , Sch. Pharmaceu. Sci. , Mukogawa Women's Univ, Nishinomiya, Japan,, 2Dept. Pharmacol. , Kinki Univ. Sch. Med. , Osaka-Sayama, Japan,, 3Dept. of Environ. Physiol. , Shimane Uni. Facult. Med. , Izumo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 156-156, 2006.

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P1K-82 Inhibition of the serotonin-induced inward current by non-narcotic antitussives in rat nodose ganglion neurons

Hitoshi Ishibashi1, Yoshiko Hatano1, 2, Mami Noda2, Kazuo Takahama3
1Dept. Physiol. , Grad Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan,, 2Lab. Pathophysiol. , Grad Sch. Pharmaceutical Sci. , Kyushu Univ. , Fukuoka, Japan,, 3Dept. Environ. & Molec. Hlth Sci. , Grad Sch. Pharmaceutical Sci. , Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 156-156, 2006.

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P1K-83 Role of K+ channels in prostanoid EP3 and TP receptors-mediated inhibition of noradrenaline release from the rat stomach

Kumiko Nakamura, Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Kunihiko Yokotani
Neuropharmacol. , Neural Integration, Grad. Sch. of Medicine, Kochi Univ. , Kochi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 156-156, 2006.

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P1K-84 Antinociceptive effect of camostat mesilate on pancreatitis-related pain in rodents

Sachiyo Nishimura1, 3, Hiroyasu Ishikura2, 3, Maho Matsunami1, Toshifumi Tsujiuchi4, Fumiko Sekiguchi1, Mitsuhide Naruse3, Toshio Nakatani5, Yoshihisa Kamanaka6, Atsufumi Kawabata1
1Div. Physiol. Pathophysiol. , Sch. Pharmaceut. Sci. , Kinki Univ. , Higashi-Osaka, Japan,, 2Div. Emerg. Crit. Care Med. , Natl. Hosp. Org. , Kyoto Med. Cent. , Kyoto, Japan,, 3Div. of Endocrin. , Clin. Res. Inst. Endocrin. Met. Dis. , Natl. Hosp. Org. , Kyoto Med. Cent. , Kyoto, Japan,, 4Dept. Life Sci. , Sch. Sci. Tech. , Kinki Univ. , Higashi-Osaka, Japan,, 5Dept. of Emerg. Crit. Care Med. Kansai Med. Univ. , Osaka, Japan,, 6Ono Pharmaceut. Co. , Ltd. , Shimamoto, Mishima-gun, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 156-156, 2006.

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P1K-85 Effects of SEA0400, a selective inhibitor of Na+/Ca2+ exchanger, on Na+ -dependent Ca2+ uptake and catecholamine release in bovine adrenal chromaffin cells

Shin Soma, Haruhiro Kuwashima, Chiaki Matsumura, Tomohiko Kimura
Dept. Pharmacol. , The Nippon Dent. Univ. , Sch. Dentist. at Niigata, Niigata, Japan.
Journal of Pharmacological Sciences 100 (suppl.2) 157-157, 2006.

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P1K-86 Occurrence and functional roles of estrogen receptors in the plasma mem-branes of bovine adrenal medulla

Nobuyuki Yanagihara1, Minhui Liu1, Yumiko Toyohira1, Masato Tsutsui1, Susumu Ueno1, Kojiro Takahashi2, Yuko Shinohara1, Kazumi Tanaka1
1Dept. Pharmacol. , Univ. Occup. & Env. Health, Sch. Med. , Kitakyushu, Japan,, 2Dept. Hosp. Pharm. , Univ. Hosp. , Univ. Occup. & Env. Health, Kitakyushu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 157-157, 2006.

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P1K-87 Effect of simvastatin, a HMG-CoA reductase inhibitor, on catecholamine secretion in bovine adrenal medullary cells

Taeko Matsuda, Yumiko Toyohira, Masato Tsutsui, Susumu Ueno, Nobuyuki Yanagihara
Dept. Pharmacol. , Univ. of Occup. & Environ. Health, Sch. Med. , Kitakyushu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 157-157, 2006.

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P1K-88 Pain is modulated by the interaction between the peripheral opioid and gluta-mate systems

YouHong Jin1, Toyohiro Fujita2, Masakazu Yoshimura3, Yoshinori Kamisaki1, Norifumi Yonehara1
1Dept. Pharmacol. , Grad. Sch. Dent. Osaka Univ. , Suita, Japan,, 2Dept. Prostho. , Grad. Sch. Dent. Osaka Univ. , Suita, Japan,, 3Cent. Res. Lab. , Maruishi Pharmaceutical Co. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 157-157, 2006.

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P1K-89 Atomic force microscopy revealed P2X2 receptor as a pore forming protein

Kenichi Nakazawa1, Yoko Yamakoshi2, Toshie Tsuchiya3, Yasuo Ohno4
1Div. Pharmacol. , Natl. Inst. Health Sci. , Tokyo, Japan,, 2Polymer Inst. , Univ. California, Santa Barbara,, 3Div. Med. Divices, Natl. Inst. Health. Sci. , Tokyo, Japan,, 4Natl. Inst. Health Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 158-158, 2006.

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P1K-90 Effects of epigallocatechin-3 gal-late, a green tea catechin, on the regulatory mechanisms of exocytosis in adrenal chro-maffin cells

Norie Murayama, Atsuko Otsuka, Nobuyuki Sasakawa, Konosuke Kumakura
Lab. Neurochem. and Neuropharmacol. , Life Sci. Insti. , Sophia Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 158-158, 2006.

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P1K-91 Effects of local anesthetics on catecholamine secretion from bovine adrenal chromaffin cell

Kenzo Mizuma, Eiichi Tachikawa, Kenzo Kudo, Yukiko Kondo, Eiichi Taira
Dept. Pharmacol. , Iwate Medical Univ. Sch. Med. , Morioka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 158-158, 2006.

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P1K-92 Effects of various classes of inhibition of glycogen synthase kinase-3β on Semaphrion3A-induced facilitation of intra-neuronal trafficking

Kan Takeuchi1, Hiroshi Usui1, Naoya Yamashita1, Yosuke Tomita1, Yoshio Goshima1, 2
1Dept. Mol. Pharmacol. & Neurobiol, , Yokohama City Univ. Grad. Sch. Med. , Yokohama, Japan,, 2CREST JST, Kawaguchi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 158-158, 2006.

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P1K-93 Cloning of the major quantitative trait locus underlying capsaicin resistance in mice

Masataka Susaki1, 2, Tsuyosi Koide2, Atsuko Mizuno1, Makoto Suzuki1
1Dept. Pharmacol. Jichi. Med. Univ. , Tochigi, Japan,, 2Animal Center, National Institute of Genetics, Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 159-159, 2006.

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P1K-94 Electrophysiological examination of analgesic action of capsaicin

Kazuhisa Fujita, Syun-ichi Yasuda, Shin-ichiro Kamiya, Masami Kato, Tohru Toyoshi, Takao Ota
Nihon Bioresearch Inc. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 159-159, 2006.

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P1K-95 Inhibition of ATP-induced inward current by docosahexaenoic acid in rat nodose ganglion neurons

Kei Eto1, 2, Yukiko Arimura1, 2, Yoshiko Hatano1, 2, Mami Noda2, Hitoshi Ishibashi1
1Dept. Bio-signaling Physiol. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan,, 2Lab. Pathophysiol. , Grad. Sch. Pharmaceutical Sci. , Kyushu Uinv. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 159-159, 2006.

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P1K-96 Enhancement of parasympathetic activity by the application of heat- and steam-generating sheets to the eyes

Yoshinao Nagashima1, Michihito Igaki1, Atsushi Suzuki1, Yukihiro Yada1, Shuichi Tsuchiya1, Toshiyuki Suzuki1, Sachiko Ohishi2
1Tokyo Research Laboratories, Kao Corporation, Tokyo, Japan,, 2Basic Research Division, Kitasato Institute, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 159-159, 2006.

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P1K-97 Effects of single and repeated administrations of KSS-694 (pilocarpine hydrochloride) on salivary secretion in MRL/Ipr mice, a model for Sjogren's syndrome

Toshihiro Inoue, Tetsuya Asari, Kazuyasu Maruyama, Yoshinobu Yamazaki, Nobuo Shibata
Development Research Department, R&D, Kissei Pharmaceutical Co. , Ltd. , Nagano-pref. , Japan
Journal of Pharmacological Sciences 100 (suppl.2) 160-160, 2006.

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P1L-01 Difference in co-innervation rates of the esophageal striated muscle motor endplates: Does it mean different degrees of inhibition on vagally mediated contractions?

Ammar Boudaka1, Juergen Woerl2, Takahiko Shiina1, Yasutake Shimizu1, Tadashi Takewaki1
1Unit. Grad. Sch. Vet. Sci. , Gifu Univ. , Gifu, Japan,, 2Anat. Inst. , Univ. Erlangen-Nuremberg, Krankenhausstrasse, Erlangen, Germany
Journal of Pharmacological Sciences 100 (suppl.2) 160-160, 2006.

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P1L-02 Influence of enteric co-innervation on vagally mediated striated muscle contractions in mouse esophagus: Establishment of an in vitro investigation using sensory stiu-mulants

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P1L-03 Selective serotonin re-uptake inhibitors aggravate antral ulcers induced by indomethacin in rat stomachs

Akiko Tanaka, Yuka Takahira, Ryo Hatazawa, Koji Takeuchi
Dept. Pharmacol. Exp. Ther. , Kyoto Pharm. Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 160-160, 2006.

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P1L-04 Role of ion transporters on the recovery of wounds induced in gastric epithelial cells

Shusaku Hayashi1, Eiji Nakamura1, 2, Yoshikazu Kubo1, Koji Takeuchi1
1Dept. Pharmacol. Exp. Ther. , Kyoto Pharm. Univ. , Kyoto, Japan,, 2Dept. Regenarative Med. Yokohama city Univ. Sch. Med, Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 161-161, 2006.

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P1L-05 Establishment of highly purified chief cell cultures from the rat stomach

Kimihito Tashima1, Muvaffak Asli2, Eiji Nakamura2, 3, Hagen. J. Susan2
1Dept. Pharmacol. Pharmaceutical Sci. , Josai International Univ. , Chiba, Japan,, 2Dept. Surgery, Beth Israel Deaconess Medical Center, USA,, 3Dept. Regenerative Medicine Yokohama City Univ. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 161-161, 2006.

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P1L-06 Protective role of the endogenous gasomessenger hydrogen sulfide in rat gas-tric mucosa

Daiki Yonezawa, Misato Miyamoto, Eiichi Taniguchi, Masami Honjo, Fumiko Sekiguchi, Atsufumi Kawabata
Div. Physiol. Pathophysiol. School of Pharmaceut. Sci. , Kinki Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 161-161, 2006.

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P1L-07 Inhibitory control of gastric acid secretion by vanilloid receptor TRPV1 -expressing neurons in the mouse isolated stomach

Yasuo Ochi1, Shingo Yano1, Toshihiko Murayama2, Syunji Horie3
1Dept. Mol. Pharmacol. Pharmacother. , Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan,, 2Dept. Chem. Pharmacol. , Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan,, 3Dept. Pharmacol. , Fac. Pharm. Sci. , Josai International Univ. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 161-161, 2006.

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P1L-08 Effect of hydrogen sulfide, a gasomessenger, on gastric vascular tension and mucosal circulation in rats

Satoko Kubo, Moto Kajiwara, Ichiko Doe, Fumiko Sekiguchi, Atsufumi Kawabata
Div. Physiol. Pathophysiol. , Sch. Pharmaceut. Sci. , Kinki Univ. , Higashi-Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 162-162, 2006.

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P1L-09 PACAP's role in the development of acute pancreatitis

Naoko Higuchi, Ken-ichi Hamagami, Kazuya Ikeda, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba
Lab. Mol. Neuropharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 162-162, 2006.

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P1L-10 Protective effects of Kakkalide on ethanol-induced lethality and acute hepatic injury in mice

Takashi Yamazaki1, Mariko Kounosu1, Atsunobu Murata1, Yoshijiro Nakajima1, Yujiro Niiho1, Yoshiro Hibi1, Junei Kinjo2, Tsuyoshi Ikeda3, Toshihiro Nohara3
1Tukuba Res. Inst. , Ohta's Isan Co. , Ltd. , Ibaraki, Japan,, 2Dep. Pharmacog. , Sch. Pharm. , Fukuoka Univ, Fukuoka, Japan,, 3Dep. Pharmacog. , Grand. Sch. Pharm. , Kumamoto Univ, Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 162-162, 2006.

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P1L-11 Changes of inhibitor of apoptosis proteins (IAPs) expression during ischemia-reperfusion in rat liver

Nobuaki Matsui, Tadatoshi Yoshikawa, Yukari Shichijo, Rie Yoshioka, Yumiko Yasui, Nobuyuki Fukuishi, Masaaki Akagi
Fac. of Pharmac. Sc. Tokushima Bunri Univ. , Tokushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 162-162, 2006.

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P1L-12 Comparison of mRNA levels of adult male-specific cytochrome P450 (CYP) isozymes in the liver of adult roof rats captured in environmentally distinct areas

Toshiaki Ishii1, Kazuhiko Nishimura2, Masakazu Nishimura1
1Dept. Pathobiol. Sci. , Obihiro Univ. Agri. Vet. Med. , Hokkaido, Japan,, 2Dept. Life Environ. Sci. , Osaka Pref. Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 163-163, 2006.

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P1L-13 Bezafibrate improves non-alcholic steatohepatitis (NASH) in mice

Yoichi Inada1, Tatsuya Nagasawa2, Shigeru Nakano1, Toru Tamura2, Tetsuaki Takahashi3, Kazuyasu Maruyama1, Yoshinobu Yamazaki1, Junji Kuroda2, Nobuo Shibata4
1Pharmacology, R&D, Kissei Pharmaceutical Co. , Ltd. , Nagano, Japan,, 2Toxicology, R&D, Kissei Pharmaceutical Co. , Ltd. , Nagano, Japan,, 3R&D Planning, Kissei Pharmaceutical Co. , Ltd. , Nagano, Japan,, 4Development Research, R&D, Kissei Pharmaceutical Co. , Ltd. , Nagano, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 163-163, 2006.

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P1L-14 Zinc supplementation improves hepatic fibrosis induced by pig serum administration in rats

Haruko Sugino1, Naoki Kumagai2, Kyoko Toda2, Satoshi Tsunematsu2, Kanji Tsuchimoto1, 2
1Div. Pathophysiol. , Kitasato Univ. Sch. Pharmaceut. So. , Tokyo, Japan,, 2Center for Liver Diseases, Kitasato Inst. Hospital, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 163-163, 2006.

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P1L-15 Effect of dehydroepiandrosterone and aging on cytochrome P450 expression in rat liver

Masami Tanaka1, 2, Minoru Watanabe2, Toshio Kumai2, Sachiko Nakaya2, Shinichi Kobayashi2
1Inst. Experimental Animals, St. Marianna Univ. Grad. Sch. Med. , Kawasaki, Japan,, 2Dept. Pharmacol. , St. Marianna Univ. Sch. Med. , Kawasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 163-163, 2006.

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P1L-16 Construction of a non -alcoholic steatohepatitis model induced by fatty liver and nitrite administration

Fusako Takayama1, 2, Narumi Hobara1, Kazuo Nakamoto1, Masafumi Ohro1, Namika Yosida1, Akitoshi Takeda1, Hiromu Kawasaki1, Toru Egashira2
1Dept. of Clin. Pharmaceut. Sci. , Grad. Sch. of Med. , Dent. and Pharmaceut. Sci. , Okayama Univ. , Okayama, Japan,, 2Dept. of Pharmaco. , Tokyo Med. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 164-164, 2006.

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P1L-17 Angiotensin type 1 receptor antagonist accelerates liver regeneration by enhanced production of hepatocyte growth factor

Ryouko Miyagi, Katsutoshi Yayama, Hiroshi Okamoto
Dept. Pharmacol. , Kobe Gakuin Univ. Sch. Pharmaceutical Sciences. , Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 164-164, 2006.

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P1L-18 Tachykinin NK3 receptor-triggered serotonin release from guinea-pig distal colon

Shu-ichi Kojima1, Masashi Ikeda2, Yuichiro Kamikawa1
1Dept. Pharmacol. , Dokkyo Univ. Sch. Med. , Tochigi, Japan,, 2Inst. Med. Sci. , Dokkyo Univ. Sch. Med. , Tochigi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 164-164, 2006.

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P1L-19 17β-estradiol induces gastroin-testinal motility disorder by increasing Rho-family G-proteins, Rnds expression in ileal smooth muscle

Aya Shimomura, Masatoshi Hori, Hiroshi Ozaki
Dept. of Vet. Pharmacol. , Grad. sch. of Agri. & Life Sci. , The Univ, of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 164-164, 2006.

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P1L-20 Effects of ghrelin peptides on con-tractility of isolated chicken gastrointestinal tracts

Takio Kitazawa, Tetsuro Taneike
Dept. Pharmacol. , Sch. Vet. Med. Rakuno Gakuen Univ. , Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 165-165, 2006.

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P1L-21 Role of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions

Ryo Hatazawa, Yuka Takahira, Ryoko Ohno, Mayu Tanigami, Akiko Tanaka, Koji Takeuchi
Dept. Pharmacology & Experimental Therapeutics, Kyoto pharma-ceutical Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 165-165, 2006.

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P1L-22 Differential responses of the anal Inner sphincter and rectal smooth muscles to various drugs in the rat

Atsuko Katoh, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi
Department of Pharmacology. , Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 165-165, 2006.

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P1L-23 Fat absorption and postprandial hypertriglyceridemia of Spontaneously Diabetic Torii (SDT) rat

Tomohiko Sasase1, Hiromi Yamamoto1, Hisayo Morinaga1, Naoto Ogawa1, Takashi Kawai1, Yasuko Mera1, Katsuhiro Miyajima2, Takeshi Ohta1, Makoto Kakutani1, Mutsuyoshi Matsushita1
1Japan Tobacco, Inc. , Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, Osaka, Japan,, 2Japan Tobacco, Inc. , Central Pharmaceutical Research Institute, Toxicology Research Laboratories, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 165-165, 2006.

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P1L-24 The suppressing mechanism of interleukin-11 on radiation induced colitis in rats

Kazuko Shichijo1, Makoto Ihara2, Eiichiro Fukuda1, Mutsumi Matsuyama1, Chun-Yang Wen1, Masahiro Nakashima3, Toshiyuki Nakayama1, Ichiro Sekine1
1Dept. Molec. Pathol. , Nagasaki Univ. Graduate Sch. Biomed. Sci, Nagasaki, Japan,, 2Radiation Biophysics, Nagasaki Univ. Graduate Sch. Biomed. Sci, Nagasaki, Japan,, 3Tissue and Histopathol, Nagasaki Univ. Graduate Sch. Biomed. Sci, Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 166-166, 2006.

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P1L-25 Effects of red wine vinegar bever-age on the colonic tissue of rodents: Functional and biochemical analyses

Atsushi Sugiyama1, 2, Akira Takahara1, Keitaro Hashimoto1
1Dept. Pharmacol. , Univ. Yamanashi, Yamanashi, Japan,, 2Yamanashi Research Center Clin. Pharmacol. , Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 166-166, 2006.

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P1L-26 Orange juice decreases the expression of multidrug resistance-associated protein 2 in rat small intestine and liver

Minoru Watanabe, Toshio Kumai, Yu Koitabashi, Naoki Matsumoto, Yuko Takeba, Shinichi Kobayashi
Dept. of Pharmacol. , St. Marianna Univ. Sch. of Med. , Kawasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 166-166, 2006.

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P1L-27 Effect of folk medicine Bidens pilosa L. on hepatic drug metabolizing enzymes of rats

Yoko Aniya, Saki Honda, Megumi Irabu, Chinatsu Yonemori
Funct. Mol. Pharmacol. , Grad. Sch. Med. , Univ. of the Ryukyus, Okinawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 166-166, 2006.

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P1L-28 Gastroprokinetic effects of Corydalis Tuber and its ingredients during the digestive state in mice

Takashi Yamazaki, Atsunobu Murata, Mariko Kounosu, Masako Yaguchi, Yoshijiro Nakajima, Yujiro Niiho, Yoshiro Hibi
Tukuba Res. Inst. , Ohta's Isan Co. Ltd. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 167-167, 2006.

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P1L-29 Effect of Rikkunshito on gastric emptying in rats may be related to seroton-ergic nervous system

Toshitaka Kido, Kiyoshi Terawaki, Akihito Mase, Mitsutoshi Yuzurihara, Yoshio Kase, Shuichi Takeda, Hiroshi Sasaki
Pharmacol. Res. Dept. , Central Lab. , Tsumura & Co. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 167-167, 2006.

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P1L-30 The preventive effects of constituents of daikenchuto and its active components on the postoperative adhesive intestinal obstruction in rats

Yohei Tokita, Kazuko Satoh, Masaru Sakaguchi, Yuichi Endoh, Ikue Mori, Iwao Sakakibara, Mitsutoshi Yuzurihara, Yoshio Kase, Shuichi Takeda, Hiroshi Sasaki
Central lab. , Tsumura&Co, Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 167-167, 2006.

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P1L-31 A survey on medical education for Japanese traditional medicine (Kampo) in undergraduate curriculum: A student perspective

Mayuko Sakanashi, Toshihiro Matsuzaki, Katsuhiko Noguchi, Matao Sakanashi
Dept. Pharmacol. , Sch. Med. , Fac. Med. , Univ. the Ryukyus, Okinawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 167-167, 2006.

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P1M-01 Change of cytokines release by an antigen-presenting cell (APC) line during the cell maturation and nicotinic stimulation

Yukiko Kondo, Eiichi Tachikawa, Kenzo Kudo, Kenzo Mizuma, Eiichi Taira
Dept. Pharmacol. , Iwate Medical Univ. Sch. Med. , Iwate, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 168-168, 2006.

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P1M-02 DU-176b, an oral and direct factor Xa inhibitor: In vitro pharmacological profile, pharmacodynamics, and antithrombotic effects

Yoshiyuki Morishima, Taketoshi Furugohri, Koji Isobe, Yuko Honda, Chikako Matsumoto, Toshio Fukuda, Nobutoshi Sugiyama, Toshiro Shibano
New Product Research Labs. II, R&D Division, Daiichi Pharmaceutical, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 168-168, 2006.

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P1M-03 Lineage-specific survivin induction by GM-CSF

Huiyuan Hu, Yayoi Shikama, Isao Matsuoka, Junko Kimura
Dept. Pharmacol. , Fukushima Medical Univ. Sch. Med. , Fukushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 168-168, 2006.

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P1M-04 Rapid assay of mouse plasma catecholamine (CAs) by a simplified alumina-adosorption method using high-performance liquid chromatograpy with electrochemical detection

Hiroko Saito1, Eisaku Sato1, Hirohisa Kato2, Shigeo Murai1
1Lab. Pharmacol. Fac. Pharm. Sci. , Aomori Univ. , Aomori, Japan,, 2Dep. Dental Pharmacol. , Iwate Med. Univ. , Morioka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 168-168, 2006.

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P1M-05 GHHPH motif in histidine rich gly-coprotein exerts anti-angiogenic effect independently of its binding to heparin

Hidenori Wake, Shuji Mori, Hideo Takahashi, Masahiro Nishibori
Okayama Univ. Grad. Sch. Med. Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 169-169, 2006.

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P1M-06 Effect of reactive oxygen species (ROS) scavengers as (+)-catechin on methe-moglobinemia

Yutaka Matsuoka1, Yuka Ansai1, Miki Amamiya1, Kaori Yoshida1, Miyuki Ishizaki3, Kiyoshi Nishitani2, Hiroshi Hara2
1Lab. Medicinal Sci. , Fac. Pharm. Sci. , Tokyo Univ. Sci. , Chiba, Japan,, 2Lab. Mol. Chem. , Fac. Pharm. Sci. , Tokyo Univ. Sci. , Chiba, Japan,, 3Lab. Bioorg. Chem. , Fac. Pharm. Sci. , Josai Int. Univ. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 169-169, 2006.

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P1M-07 Effects of Kurozu on risk factor of arteriosclerotic disease

Sadao Nakayama1, Manami Nose1, Kumiko Wada1, Kazumi Nakayama1, Hiroshi Shigehisa2, Kazunobu Tokuda3
1Sch. NR. Showa Univ. , Yokohama, Japan,, 2Fukuyama Butsusan, Kagoshima, Japan,, 3Tokuda Clinic, Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 169-169, 2006.

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P1M-08 Binding of wortmannin to Nα-acetyl lysine and Nα-acetyl cysteine

Minoru Isosaki1, 2, Masatoshi Tanioku2, Hitoshi Nakayama1, Hiroyasu Satoh1, Masanori Yoshizumi1
1Dept. Pharmacol. , Nara Med. Univ. , Nara, Japan,, 2Dept. Pharmacy, Nara Med. Univ. Hospital, Nara, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 169-169, 2006.

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P1M-09 Effects of unpollished rice vinegar (Kurozu) on risk factor of life style diseases in human

Sadao Nakayama1, Manami Nose1, Kumiko Wada1, Kazumi Nakayama1, Hiroshi Shigehisa2, Kazunobu Tokuda3
1Sch. NR. Showa Univ. , Yokohama, Japan,, 2Fukuyama butsusan, Kagoshima, Japan,, 3Tokuda clinic, Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 170-170, 2006.

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P1M-10 Possible roles of neuropeptide YY3 receptor in the rat aortic endothelial cell (RAEC) proliferation

Zhi-yong Chen1, 2, Guo-gang Feng1, Kimitoshi Nishiwaki2, Yasuhiro Shimada2, Naohisa Ishikawa1
1Dept. Pharmacol. , Med. Sch, Aichi Med. Univ. , Aichi, Japan,, 2Dept. Anesthesiol. , Med. Sch. Nagoya Univ. , Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 170-170, 2006.

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P1M-11 Transient ischemia induces structural damage of the rat retinal blood vessels

Shinichiro Hoshino, Tsutomu Nakahara, Kenji Sakamoto, Maki Saito, Kunio Ishii
Dept. Mol. Pharmacol. , Kitasato Univ. Sch. Pharm. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 170-170, 2006.

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P1M-12 Vascular tube formation of CD44+ CD90+ cells isolated from neurospheres

Kazuhiko Oishi, Yuko Ito
Dept. Pharmacol. , Meiji Pharmaceutical Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 170-170, 2006.

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P1M-13 Angiotensin type 2 receptor-dependent phosphorylation of eNOS in rat thoracic aorta after the abdominal aortic banding

Daichi Imazu, Katsutoshi Yayama, Hiroshi Okamoto
Dept. Pharmacol. , Kobe Gakuin Univ. Sch Pharmaceutical Sciences, Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 171-171, 2006.

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P1M-14 Angiotensin type 2 receptor stimulates eNOS production and phosphorylation in endothelial cells

Yukiko Kunisue1, Katsutoshi Yayama1, Hiroyuki Mizoguti2, Hiroshi Okamoto1
1Dept. Pharmacol. , Kobe Gakuin Univ. Pharmaceutical Sciences, Kobe, Japan,, 2Laboratory of Gene Transfer and Regulation, National Institute of Biomedical Innovation, , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 171-171, 2006.

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P1M-15 Region-specific impairment of endothelial function in rabbit cerebral arteries after long-term in vivo administration of nitroglycerin

Yoshimasa Watanabe, Nobuyoshi Kusama, Junko Kajikuri, Takeo Itoh
Dept. Cellular and Molecular Pharmacol. , Graduate Sch. Medical Sciences, Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 171-171, 2006.

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P1M-16 Regional differences in the production of epoxyeicosatrienoic acids among rabbit aortae, determined by LC/MS/MS

Kenichi Kumasaka1, 2, Hitomi Matsuda2, Miwa Kondo2, Jun Taniguchi3, Takashi Miwa3, Kiyoshi Yamaguchi4, Yoko Notoya3, Hideo Honda5
1)Chemistry Div. , Kanagawa Pref. Inst. Pub. Health, Kanagawa, Japan,, 2)2nd Dept. Physiol. , Sch. of Med. , Showa Univ. , Tokyo, Japan,, 3)Dept. Internal Med. , Tokyo Med. Univ. , Tokyo, Japan,, 4)Dept. Pathobiol. , Coll. of Vet. Med. , Tennessee Univ. , Knoxville,, 5)Dept. Endocrine Pharmacol. , Tokyo Univ. of Pharm. Life Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 171-171, 2006.

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P1M-17 Mechanisms underlying endothelium-dependent effects on the aorta of apolipoprotein-E-deficient mice

Mayumi Mori1, Hiromi Tsushima1, Seigo Fujimoto1, Toyohiro Tada2, Jin-ichi Itoh3
1Dept. Cell. Mol. Pharmacol. , Nagoya City Univ. , Grad. Sch. Med. . Sci. , Nagoya, Japan,, 2Dept. Pathol. , Nagoya City Univ. , Sch. Nurs. , Nagoya, Japan,, 3Dept. Biochem. Cell Biol. Metabol. , Nagoya City Univ. , Grad. Sch. Med. Sci. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 172-172, 2006.

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P1M-18 New approach to estimate Ca2+ response and vasoreaction of small artery employing real-time confocal microscopy

Yumiko Enokida1, Terumasa Hashimoto1, Masayuki Yamamoto1, Yasushi Sakai2, Hisayuki Ohata1, Kazuo Honda1
1Dept. Pharmacol. , Showa Univ. Sch. Pharm. , Tokyo, Japan,, 2Div. Physiol. , Showa Univ. Sch. Nursing and Rehabili. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 172-172, 2006.

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P1M-19 Lipo-PGE1 accelerates ischemia-induced neovascularization in mouse hindlimbs

Yukiko Matsui1, 2, Satomi Kita2, Takeshi Katsuragi2, Hiroyuki Ohjimi1, Takahiro Iwamoto2
1Dept. Plastic and Reconstructive surgery, Fukuoka Univ. Hospital, Fukuoka, Japan,, 2Dept. Pharmacol. , Fukuoka Univ. Sch. Med. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 172-172, 2006.

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P1M-20 Alteration of cell-to-cell connection under high-glucose condition in arterial endothelial cells

Koji Nobe, Mari Miyatake, Kazuo Honda
Dept. Pharmacol. , Showa Univ. Sch. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 172-172, 2006.

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P1M-21 Involvement of facilitated reen-dothelialization, decreased endogenous NOS inhibitor and restored NO generation with estrogen in improving the accelerated intimal hyperplasia following ovariectomy

Tomoko Ishibashi1, Satoshi Obayashi1, Shuichi Sakamoto1, Takeshi Aso1, Hiroshi Azuma2
1Comprehensive Reproductive Med. , Tokyo Med. , and Dent. , Univ. , Tokyo, Japan,, 2Dept. , Biosystem Regulation, Inst. Biomater. & Bioengin. , Tokyo Med. , and Dent. , Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 173-173, 2006.

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P1M-22 Effect of hyperglycemia without hyperinsulinemia on vascular responsiveness in pithed rats

Yoshito Zamami1, Shingo Takatori2, Satoko Miyasita1, Kousuke Yamawaki1, Mitsunobu Mio2, Husako Takayama1, Hiromu Kawasaki1
1Dept. Clin. Pharm. Sci. , Grad. Sch. Med. Den. Pharm, Sci. , Okayama Univ, Okayama, Japan,, 2Lab Pharmacol. , Dept. Clin. Pharm. Sch. Pharm. , Shujitsu Univ, Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 173-173, 2006.

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P1M-23 Basic fibroblast growth factor induces tetrahydrobiopterin synthesis through stimulation of Erk pathway in vascular endothelial cells

Tetsuya Sasaki1, Shunichi Shimizu1, Masakazu Ishii1, Tamio Hagiwara2, Akira Miyazaki2, Yuji Kiuchi1
1Dept. Pathophysiol. , Sch. Pharm. Sci. , Showa Univ. , Tokyo, Japan,, 2Depart. Biochem. , Sch. Med. , Showa Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 173-173, 2006.

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P1M-24 Decrease in nitric oxide and increase in CYP2C9-derived arachidonic acid methabolites production in rabbit renal artery from short-term hypercholesterolemia

Jun Taniguchi1, Hideo Honda2, Youichi Shibusawa3, Kenichi Kumasaka4, Hitomi Matsuda4, Miwa Kondo4, Takashi Miwa1, Yoko Notoya1
1)Dept. 3rd Internal Med. , Tokyo Med. Univ. , Tokyo, Japan,, 2)Dept. Endocrine Pharmacol. , Tokyo Univ. of Pharm. Life Sci. , Tokyo, Japan,, 3)Dept. Structural Biol. Anal. Sci. , Tokyo Univ. of Pharm. Life Sci. , Tokyo, Japan,, 4)2nd Dept. Physiol. , Sch. of Med. , Showa Univ, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 173-173, 2006.

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P1M-25 Laminar shear stress induces cytochrome P4501A1 through the aryl hydro-carbon receptor-xenobiotic response element signaling pathway in vascular endothelial cells

Zhiyi Han, Yoshikazu Miwa, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. , Fac. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 174-174, 2006.

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P1M-26 Nuclear factor- κB regulates endothelin-1 gene expression

Yuuki Ka, Mamoru Ohkita, Miwa Kanematsu, Masanori Takaoka, Yasuo Matsumura
Dept. Pharmacol. , Osaka Univ. Pharmaceut. Sci. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 174-174, 2006.

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P1M-27 Effects of hypoxia on endothelin-1 production in cultured vascular endothelial cells

Ayako Kitamura, Mamoru Ohkita, Shinya Ohkuma, Asako Takeda, Masanori Takaoka, Yasuo Matsumura
Dept. Pharmacol. , Osaka Univ. Pharmaceut. Sci, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 174-174, 2006.

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P1M-28 Chronic nitroglycerine administration reduces endothelial nitric oxide production in rabbit mesenteric resistance artery

Tamao Yamamoto1, Yoshimasa Watanabe1, Junko Kajikuri2, Nobuyoshi Kusama2, Yoshikatsu Suzuki1, Takeo Itoh2
1Dept. Obstet. Gynecol. , Nagoya City Univ. Med. Sch. , Nagoya, Japan,, 2Dept. Cell Mol Pharmacol. , Nagoya City Univ. Med. Sch. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 174-174, 2006.

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P1M-29 Theaflavin-3,3-digallate inhibits tube formation

Sei Kobayashi1, Shinichi Iwai2, Kazuko Tsujiyama2, Yuko Udaka2, Takeyuki Sanbe1, Katsuji Oguchi2
1Dept. of Otorhinolaryngology, Showa Univ. hujigaoka hospital, Kanagawa, Japan,, 2Dept. of Pharmacology, School of Medicine Showa University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 175-175, 2006.

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P1M-30 Acute effect of elevated circulating free fatty acid levels on endothelial function in genetically obese rats

Katsuhiko Noguchi1, Namio Higa2, Ichiro Chinen2, Michio Shimabukuro2, Naobumi Hamadate1, Matao Sakanashi1
1Dept. Pharmacol. , Sch. Med. , Fac. Med. , Univ. Ryukyus, Okinawa, Japan,, 2Dept. 2nd Internal Med. , Sch. Med. , Fac. Med. , Univ. Ryukyus, Okinawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 175-175, 2006.

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P1M-31 Vascular dysfunction in the heritable hypertriglyceridemic rabbits

Akira Ishihata1, Tomomi Aita2, Tomoko Shimoda2, Mikako Kaga2, Kazuo Ohwada3, Tsunekata Ito3, Hitonobu Tomoike4, Yumi Katano2
1Dept. Cardiovascular Physiol. , Yamagata Univ. Sch. Med. , Yamagata, Japan,, 2Div. Theoretic. Nurs. Pathophysiol, Yamagata Univ. Sch. Med. , Yamagata, Japan,, 3Laboratory Animal Center, Yamagata, Japan,, 4National Cardiovascular Center, Suita, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 175-175, 2006.

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P1M-32 Beneficial effects of cyclo-hexenonic long-chain fatty alcohol on STZ-induced diabetic rat aorta

Yukako Kinoshita1, Motoaki Saito1, Itaru Satoh1, Chiko Shinbori1, Tomoharu Kono1, Hiroto Suzuki2, Masashi Yamada2, Keisuke Satoh1
1Dept. of Pathophysiological and Therapeutic Sci. , Div. of Mol. Pharmacol. , Tottori Univ. Faculty of Med. , Yonago, Japan,, 2Meiji Dairies Corporation Pharmaceuticals Dept. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 175-175, 2006.

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P1M-33 Detection of amyloidosis by BF-227, a ligand for amyloid Aβ fibrils

Yousuke Fujikawa1, 2, Nobuyuki Okamura1, 2, Shozou Furumoto2, Yoshinobu Hosii3, Masahito Yamada4, Tokuhiro Ishihara3, Yukitsuka Kudo2, Kazuhiko Yanai1
1Dept. Pharmacol. , Tohoku Univ. Sch. Med. , Miyagi, Japan,, 2TUBERO, Tohoku Univ. , Miyagi, Japan,, 3Dept. Surg. Pathol. , Yamaguchi Univ. Sch. Med. , Yamaguchi, Japan,, 4Kanazawa Univ. Grad. Sch. Med. Sci. , Kanazawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 176-176, 2006.

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P1M-34 Astaxanthin ameliorates features of metabolic syndrome in rat model SHR/NDmcr-cp (cp/cp)

Ghazi Hussein1, 2, Hirozo Goto3, Takako Nakagawa3, Kinzo Matsumoto1, Ushio Sankawa2, Hiroshi Watanabe1
1Div. Medicinal Pharmacol. , Inst. Nat. Med. , Univ. Toyama, Toyama, Japan,, 2Int. Res. Centr. Trad. Med. , Toyama, Japan,, 3Dept. Kampo Diagnostics, Inst. Nat. Med. , Univ. Toyama, Toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 176-176, 2006.

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P1M-35 Relationship between PGE2 and VEGF on angiogenesis in human endothelial cells

Toshihiro Sakurai, Kazuhiro Tamura, Hiroshi Kogo
Dept. Endocrine Phrmacol. , Tokyo University Pharmacy & Life Science, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 176-176, 2006.

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P1M-36 Adiponectin inhibits cell migration induced by insulin-like growth factor-1 in vascular smooth muscle cells

Yuki Izawa1, Keisuke Ishizawa2, Yoshiko Fujita1, Yayoi Fukuhara1, Hideki Ohnishi1, Yuki Motobayashi1, 2, Yasuhisa Kanematsu1, Koichiro Tsuchiya3, Toshiaki Tamaki1
1Dept. Pharmacol. , Inst. HBS, Univ. of Tokushima Grad. Sch. , Tokushima, Japan,, 2Dept. Pharmacy, Tokushima Univ. Hosp. , Tokushima, Japan,, 3Dept. Clin. Pharmacol. , Inst. HBS, Univ. Tokushima Grad. Sch. , Tokushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 176-176, 2006.

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P1M-37 Involvement of polyamine and proline pathway in initiation/development of intimal hyperplasia in premenopausal human uterine arteries

Galina Vasileva Marinova1, Satoshi Obayashi1, Tomoko Ishibashi1, Misako Hirata1, Shuichi Sakamoto1, Takeshi Aso1, Hiroshi Azuma2
1Comprehensive Reproductive Med. , Tokyo Med. and Dent. Univ. , Tokyo, Japan,, 2Dept. Biosystem Regulation, Inst. Biomater. and Bioengin. , Tokyo Med. and Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 177-177, 2006.

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P1M-38 NF-κB inactivation is involved in the mechanisms of sexual dimorphic response to atorvastatin against vascular injury

Daisuke Kurumazuka1, Tatsuhiko Mori2, Hisashi Shirakawa1, Sayaka Kimura1, Tetsuya Hayashi2, Yasushi Kitaura2, Yasuo Matsumura1
1Dept. Pharmacol. , Osaka Univ. Pharmaceut. Sci. , Takatsuki, Japan,, 2Third Dept. Med. , Osaka Med. Col. , Takatsuki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 177-177, 2006.

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P1M-39 Effect of condroitinase on the der-matan sulfate facilitated arginine amidase activity release from rabbit arteries

Reiko Ishii-Nozawa1, Yoshifumi Matsuda2, Kyosuke Miyazaki3, Koichi Takeuchi1
1Dept. Clin. Pahrmacol. , Meiji Pharmaceut. Univ. , Tokyo, Japan,, 2Dept. Func. Bioanal. , Meiji Pharmceut. Univ. , Tokoy, Japan, 3Seikagaku Co. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 177-177, 2006.

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P1M-40 Modification of Angiotensin II-induced contractions by bradykinin release via endothelial AT2 receptors in porcine basilar artery

Atsushi Miyamoto, Satoru Kake, Aya Inoue, Akira Nishio, Shigeru Ishiguro
Dep. Vet. Pharmacol. , Fac. Agri. , Kagoshima Univ. , Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 177-177, 2006.

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P1M-41 Apocynin normalize the abnormal vasomotor activities in mesenteric arteries from cholesterol-fed mice

Kiyoto Miyamori, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept. Physiol. and Morphol. , Inst. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 178-178, 2006.

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P1M-42 Possible involvement of Jak2-STAT pathway on the stimulation of tetrahy-drobiopterin synthesis by hydrogen peroxide in vascular endothelial cells

Toshihito Hiroi1, Shunichi Shimizu1, Masakazu Ishi1, Tamio Hgiwara2, Akira Miyazaki2, Yuji Kiuchi1
1Dept. Pathophysiol. , Sch. Pharm. Sci. , Showa Univ. , Tokyo, Japan,, 2Depart. Biochem. , Sch. Med. , Showa University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 178-178, 2006.

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PIN-01 Bioimaging of caspase activation during ER stress-induced cell death

Takuo Suzuki1, Yukimi Sakurai2, Hiroshi Kawai3, Akiko Ishii1, Tetsu Kobayashi1, Hisayuki Ohata2, Kazuo Honda2, Toru Kawanishi1
1Natl. Inst. of Health Sci. , Tokyo, Japan,, 2Showa Univ. , Tokyo,, 3Jousai Int. Univ. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 178-178, 2006.

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P1N-02 Enhancement of sensitivity against cell death in mutated focal adhesion kinase transfected PC12 cells

Eriko Aizu-Yokota, Eriko Takeuchi, Yayoi Murakami, Yoshiko Sonoda, Tadashi Kasahara
Dept. Biochem. , Kyoritsu Univ. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 178-178, 2006.

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P1N-03 Induction of apoptosis and inhibition of telomerase activity by propolis in U937 cells

Masaaki Ishikawa1, Syu-ichi Kanno1, Mayuko Ujibe1, Asako Aisaka2, Takeshi Tadano3
1Dept. Pharmacol. Toxicol. , Cancer Res. Inst. , Tohoku Pharm. Univ. , Sendai, Japan,, 2ChatBlanc inc. , Tokyo, Japan,, 3Dept. Pharmacol. , Tohoku Pharm. Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 179-179, 2006.

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P1N-04 Modulation factors of tumor-specific cytotoxic activity of anthracyclines

Hiroshi Sakagami1, Mariko Ishihara2, Miki Ogino1, Yuki Itoh1, Toshihiro Sudoh1, Marie Mineda1, Fumika Suzuki1, Ken Hashimoto1, Masahiro Sasaki3, Jun Shimada3
1Div. Pharmacology, Meikai University Sch. Dent. , Saitama, Japan,, 2Div. Basic Chem. , Meikai Univ. Sch. Dent. , Saitama, Japan,, 3Div. Oral Maxillo & Facial Surg, Meikai Univ. Sch. Dent. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 179-179, 2006.

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P1N-05 Application of semiempirical molecular orbital method for the estimation of structure and cytotoxic activity of butelinic acid derivatives

Mariko Ishihara1, Hiroshi Sakagami2
1Div. Chem. , Meikai Univ. Sch. Dent. , Saitama, Japan,, 2Div. Pharmacol. , Meikai Univ. Sch. Dent. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 179-179, 2006.

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P1N-06 Mechanism of apoptosis induced by rotenone

Masahiko Watabe, Toshio Nakaki
Dept. Pharmacol. , Teikyo Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 179-179, 2006.

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P1N-07 Oligomerization of GAPDH via formation of the intermolecular disulfide is involved in irreversible inhibition of the activity by oxidative stresses

Aki Nakamura, Hidemitsu Nakajima, Fumiaki Hata, Tadayoshi Takeuchi
Dept. of Veterinary Pharmacology, Graduate Sch. of Life and Environmental Sciences, Osaka Prefecture Univ. , Sakai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 180-180, 2006.

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P1N-08 Adenosine mediated signal trans-duction for the protection of apoptosis and the cell differentiation

Kazu Tsujiko, Keita Yoshidome, Yuko Maki, Takahiro Ando, Norihisa Fujita
Dept. Bioinformatics, Fac. Info and Sci. , Ritsumeikan Univ. , Kusatsu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 180-180, 2006.

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P1N-09 Implication of Phospolipase D1 in cell survival against pepsin-digested lacto-ferrin peptide(s)-induced apoptotic cell death in oral squamous cell carcinoma

Takayuki Sakai, Mitsuru Kawaguchi, Kouhei Swaki, Migiwa Okubo, Yasuhiro Kosuge, Takashi Shinomiya
Dept. Pharmacol. , Tokyo Dent. Coll. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 180-180, 2006.

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P1N-10 IP3 receptor-dependent Ca2+ entry in DT40 cells

Takao Morita, Akihiko Tanimura, Yosuke Tojyo
Dept. Dental Pharmacology, Sch. Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 180-180, 2006.

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P1N-11 Discovery of novel TRPC channel blockers

Sihgeki Kiyonaka1, Motohiro Nishida2, Kenta Kato1, Minoru Wakamori1, Emiko Mori1, Masakazu Ishii4, Tsutomu Kobayashi3, Yasuo Mori1
1Grad. Sch. Engin. , Kyoto Univ. , Katsura Campass Kyoto, Japan,, 2Grad. Sch. Pharmaceu. Sci. , Kyushu Univ. , Maidashi, Higashiku, Fukuoka, Japan,, 3Tanabe Seiyaku Co. , Ltd. , Toda city, Saitama, Japan,, 4Sch. Pharm. Sci. , Showa Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 181-181, 2006.

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P1N-12 Discovery of a novel modulator for insect ryanodine receptor

Kenta Kato1, Shigeki Kiyonaka1, Emiko Mori1, Takao Masaki2, Noriaki Yasokawa2, Hiroshi Hamaguchi2, Yasuo Mori1
1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan,, 2Nihon Nohyaku Co. , Ltd. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 181-181, 2006.

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P1N-13 Regulation of Ca2+ mobilization by prolactin in mammary gland cells

Haruo Takmeura1, 2, Utchariya Anantamongkol2, Nateetip Krishnamra2, Yoshiyuki Horio1
1Dept. Pharmacol. , Sapporo Med. Univ. Sch. Med. , Sapporo, Japan,, 2Dept. Physiol. , Faculty Sci. , Mahidol Univ. , Bangkok, Thailand
Journal of Pharmacological Sciences 100 (suppl.2) 181-181, 2006.

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P1N-14 Differential intracellular signaling through cysLT2 receptor by cysteinyl leukotrienes

Yoshiyuki Itoh, Takahito Kitajima, Yoshihiro Kimura, Toshio Tanaka
Dept. Pharmacol. , Mie Univ. Sch. Med. , Mie, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 181-181, 2006.

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P1N-15 Homophilic cell contact activated Rac1 and up-regulated p27Kip1 transcription in vascular endothelial cells

Mayumi Hirano, Katsuya Hirano, Naohisa Niiro, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol. , Res. Inst. Angiocardiol. , Grad. Sch. Med. Sci, Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 182-182, 2006.

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P1N-16 Identification of Par3 as a novel substrate of Rho-kinase

Masanori Nakayama1, Takashi Nishimura1, Masayuki Sugimoto2, Takaaki Goto1, Shigeo Ohno3, Mutsuki Amano1, Kozo Kaibuchi1
1Dept. Cell Pharmacology. Graduate School of Medicine Nagoya University, Aichi, Japan,, 2Dept. of Vascular Surgery Graduate School of Medicine Nagoya University, Aichi, Japan,, Dept. of Molecular Biology Yokohama City Univ. School of Medical Science, Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 182-182, 2006.

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P1N-17 Mastoparan inhibits Gs-mediated signal transduction through changing the localization of Gαs in lipid rafts

Jun Sugama1, Satoko Ohkubo2, Norimichi Nakahata1, 3
1Dept. Cellular Signaling, Grad. Sch. Pharmaceut. Sci. , Tohoku Univ. , Sendai, Japan,, 2Div. pharmacol. , Natl. Inst. Health Sci. , Tokyo, Japan,, 3Tohoku Univ. 21st Century COE Program "CRESCENDO", Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 182-182, 2006.

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P1N-18 R9AP regulates RGS9-1 activity through its targeting to lipid rafts

Shinichi Tokue1, Satoko Ohkubo2, Harden T. Kendall3, Norimichi Nakahata1, 4
1Dept. Cell. Signaling, Grad. Sch. Pharmaceut. Sci. Tohoku Univ, Sendai, Japan,, 2Div. Pharmacol. , Nati. Health Sci. , Tokyo,, 1Dept. Pharmacol. , Sch. Med. Univ. North Carolina, North Carolina, 275-99,, 4Tohoku Univ. 21st Century COE Program CRESCENDO, Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 182-182, 2006.

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P1N-19 EGCG inhibits cancer cell growth through retinoblastoma protein

Lisa Hirose1, 2, 3, Rie Takahashi1, 2, Mari Ohta1, 2, Akiyuki Kawawa1, 2, Ichiro Kimura3, Yoshio Uehara2, Shunichiro Kubota1, 2
1Dept. of Life Sci, Univ. of Tokyo, Tokyo, Japan,, 2Health Service Center, Univ. of Tokyo, Tokyo, Japan,, 3Grad. Sch. of Human Sci, Waseda Univ. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 183-183, 2006.

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P1N-20 Short time hypoxia stimulates cell growth in vitro

Akiyuki Kawawa1, 2, 3, Rie Takahashi1, 2, Keiko Yasuda1, 2, Tadako Murayama3, Yoshio Uehara2, Shunichiro Kubota1, 2
1Dept of Life Sci, Univ. of Tokyo. , Tokyo, Japan,, 2Health Service Center2, Komaba Branch, University of Tokyo, Tokyo, Japan,, 3College of Eng, Kanto-Gakuin, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 183-183, 2006.

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P1N-21 The suppression of mTOR signaling pathway underlies the anti-tumor effects of LAT1 inhibitors

Arthit Chairoungdua, Patthara Kongsuphol, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharm. & Toxicol. , Kyorin Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 183-183, 2006.

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P1N-22 Participation of hOat3 in acquire-ment of drug resistance against 5-FU

Akiko Nagatani, Masako Yasuda, Masayuki Ohbayashi, Tomofumi Hayashi, Yasuna Kobayashi, Toshinori Yamamoto
Dept. Clinical Pharmacy, Showa Univ. Sch. Pharmaceutical Sciences. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 183-183, 2006.

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P1N-23 U0126, a specific inhibitor of activation of extra cellular signal-regulated kinase, inhibited the proliferation of a human pancreatic cancer cell line, KP4

Katsushige Mizuno1, Sachi Mikami2, Hitoshi Ushida2, Masaya Shimomura2, Hisakatsu Nawata2
1Dept. Information science and Engineering, Ritsumeikan University, Shiga, Japan,, 2Dept. Science and Engineering, Ritsumeikan University, Shiga, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 184-184, 2006.

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P1N-24 Effects of branched-chain amino acids on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes

Mitsutoshi Kimura, Masahiko Ogihara
Dept. Clin. Pharmacol. , Fac. Pharm. Sci. , Josai Univ. , Saitaima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 184-184, 2006.

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P1N-25 Increased expression of PAR-2 by bFGF in synovial fibroblasts derived from patients with rheumatoid arthritis

Kazuki Abe1, Akhmed Aslam2, Andrew. F. Walls2, Toshitsugu Sato1, Hideo Inoue1
1Pharmacological Research Dept, Minophagen Pharmaceutical Co. , Kanagawa, Japan,, 2Immunopharmacology Group, Univ. Southampton, Southampton General Hospital, Southampton, UK.
Journal of Pharmacological Sciences 100 (suppl.2) 184-184, 2006.

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P1N-26 Suboptimal amount of TNF-α potently suppresses osteoblast differentiation in slight acidosis

Kohtaro Kato, Ikuo Morita
Dept. Cell. Physiol. Chem. , Tokyo Med. and Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 184-184, 2006.

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P1N-27 Regulation of neurite extension mediated by neuronal calcium sensor-1 in nerve growth cone

Chihiro Imaizumi1, Andreas Jeromin2, Katsuhiko Mikoshiba3, 4, Yoshio Goshima1, 5, Kohtaro Takei1, 5
1Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. , Grad. Sch. Med. , Yokohama, Japan,, 2Dept. Neurosci. , Baylor Cllege Med. , Houston, TX, USA,, 3Dept. Mol. Neurobiol. , Inst. Med. Sci. , The Univ. Tokyo, Tokyo, Japan,, 4Lab. Dev. Neurobiol. , RIKEN BSI, Saitama, Japan,, 5JST CREST, Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 185-185, 2006.

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P1N-28 Anthraquinones suppress aryl hydrocarbon receptor transformation induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin

Itsuko Fukuda1, Atsushi Kaneko2, Shin Nishiumi2, Tadashige Nozaki1, Kiyoshi Ohura1, Hitoshi Ashida2
1Dept. Pharmacol. , Osaka Dental Univ. , Osaka, Japan,, 2Dept. Biofunctional Chem. , Facl. Agriculture, Kobe Univ. , Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 185-185, 2006.

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P1N-29 Determination of histamine and τN-methylhistamine using HPLC-amperome-try

Kazutaka Maeyama, Keiko Watanabe, Martin Maldonado
Dept. Pharmacol. Ehime Univ. Sch. Med. , Shitsukawa, Toon, Ehime, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 185-185, 2006.

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P1N-30 The regulatory mechanisms in cell surface expression of thromboxane A2 receptor

Masako Sasaki1, 2, Katsutoshi Miyosawa1, Jun Sukegawa3, Teruyuki Yanagisawa2, 3, Satoko Ohkubo1, Norimichi Nakahata1, 2
1Dept. Cellular Signaling, Grad. Sch. Pharmaceut. Sci. , Tohoku Univ. , Sendai, Japan,, 2Tohoku Univ. 21st Century COE Program "CRESCENDO", Sendai, Japan,, 3Dept. Mol. Pharmacol. , Grad. Sch. Med. , Tohoku Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 185-185, 2006.

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P1N-31 Thromboxane A2 enhances IL-6 biosynthesis via CREB in 1321N1 human astrocytoma cells

Yutaro Obara1, 2, Hitoshi Kurose3, Norimichi Nakahata1, 2
1)Dept. Cellular Signaling, Grad. Sch. Pharmaceut. Sci. , Tohoku Univ. , Sendai, Japan,, 2)21st Century Program "CRESCENDO", Sendai, Japan,, 3Dept. Pharmacol. and Toxicol. , Grad. Sch. Pharmaceut. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 186-186, 2006.

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P1N-32 The role of N-terminal palmitoylation of Sonic hedgehog

Yoichiro Abe, Takako Niikura, Yoshiko Kita
Dept. Pharmacol. , Keio Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 186-186, 2006.

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P1N-33 Mechanism of cPLA2α activation induced by tyrosine phosphorylation signal

Tomoko Taniguchi, Masaya Shimizu, Hiroyuki Nakamura, Tetsuya Hirabayasi, Hiromichi Fujino, Toshihiko Murayama
Dept. Chem. Pharmacol. , Grad. Sch. Pharm. Sci. , Chiba Univ, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 186-186, 2006.

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P1N-34 Comparative study of culture condition on CYP3A4 regulation in primary hepatocytes

Yuko Takeba, Toshio Kumai, Sachiko Nakaya, Naoki Matsumoto, Shinichi Kobayashi
Dept. Pharmacol. , St. Marianna Univ. Sch. Med. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 186-186, 2006.

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P1N-35 Development and application of a stable HeLa cell line capable of site-specific transgenesis by the Cre/mutant lox system-part I: Establishment and phenotype analysis of a human TNFRI knockdown cells

Fumiyo Saito, Hirofumi Yokota, Yoshihisa Sudo, Yoshikuni Yakabe
Chemicals Evaluation and Research Institute, Japan, Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 187-187, 2006.

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P1N-36 Effects of polychlorinated biphenyls on cultured rat embryos

Masaharu Akita1, Mari Kato1, Atsushi Yokoyama2, Kouichi Haraguchi3, Nobuyuki Koga4, Hitoshi Kontani5
1Depart. Nutrition and Dietetics, Faculity of Family and Consumer Sciences, Kamakura Women's University, Kanagawa, Japan,, 2Kanagawa Life Science Research Laboratory, Kanagawa, Japan,, 3Daiichi College of Pharm. Science, Fukuoka, Japan,, 4Nakamura Gakuen Univ. , Fukuoka, Japan,, 5Hokuriku Univ. , Ishikawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 187-187, 2006.

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P1N-37 Transport of methylmercury through the epithelial type amino acid transport system B0

Islam Rafiqul, Promsuk Jutabha, Taku Hirata, Naohiko Anzai, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. Toxicol. , Kyorin Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 187-187, 2006.

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P1N-38 Structural determinants in the heavy chain subunits of heterodimeric amino acid transporters for recognition of light chains

Ahmed Nesar, Panjamaporn Sangwoung, Arthit Chairoungdua, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. Toxicol. , Kyorin Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 187-187, 2006.

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P1N-39 Increase of ADP uptake induced by 2-deoxyglucose in MDCK cells

Keisuke Migita, Yumei Zhao, Takeshi Katsuragi
Dept. Pharmacol. , Fukuoka Univ. Sch. Med. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 188-188, 2006.

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P1N-40 Effect of Boiogito on the cell membrane water permeability

Naoki Fujitsuka1, Bunsho Makino2, Ikue Mori2, Tomohisa Hattori1, Iwao Sakakibara2, Yoshio Kase1, Shuichi Takeda1, Yoichiro Isohama3, Takeshi Miyata3
1Pharmacol. Res. Dept. , Central Lab. Tsumura & Co. , Ibaraki, Japan,, 2Pharmacognosy & Medicinal Resources Res. Dept. , Central Lab. Tsumura & Co. , Ibaraki, Japan,, 3Dept. Chemico-Pharmacol. Sci. , Grad. Sch. Pharmac. Sci. , Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 188-188, 2006.

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P2K-01 Opioid peptide evaluated from computational chemistry

Taizo Hayano1, Shiroh Kishioka2, Hiroyuki Yamamoto2
1Div. Psychiat. Asahikai. Wakaura. Hp. , Wakayama, Japan,, 2Dept. Pharmacol. School. Med. Wakayama. Med. Univ. , Wakayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 188-188, 2006.

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P2K-02 Characterization of brain cyclooxy-genase involved in CRF-induced central activation of sympatho-adrenomedullary outflow in rats

Lianyi Lu, Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Kumiko Nakamura, Junichi Arai, Kunihiko Yokotani
Neuropharmacol. , Neural Integration, Grad. Sch. of Medicine, Kochi Univ. , Kochi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 188-188, 2006.

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P2K-03 Central injection of hypertonic saline activates angiotensin II-sensitive neurons in the anterior hypothalamic area of rats

Yukihiko Hagiwara, Masahiro Fujimura, Youhei Sasaki, Ryuji Fukumori, Takao Kubo
Dept. Pharmacol. , Showa Pharmaceut. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 189-189, 2006.

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P2K-04 Altered feeding behavior in mice lacking the V1a vasopressin receptor

Toshinori Aoyagi, Jyunichi Birumachi, Akito Tanoue
Dept. Pharmacol. , Natl. Res. Inst. Child Health Dev. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 189-189, 2006.

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P2K-05 The localization of vasopressin V1B receptor in the mouse central nervous system

Toshiki Tanaka, Taka-aki Koshimizu, Mami Hizume, Gozoh Tsujimoto
Dept. Genomic Drug Discovery Sci. , Grad. Sch. Pharmaceu. Sci. Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 189-189, 2006.

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P2K-06 Central NF-κB is involved in the CRF-induced central activation of sympatho-adrenomedullary outflow in rats

Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Junich Arai, Liany Lu, Kumiko Nakamura, Mieko Yorimitsu, Arina Yamada, Kunihiko Yokotani
Dept. neuropharmacol. , Neural Integration, Grad. Sch. of Medicine, Kochi Univ. , Nankoku Okoutyou Kohasu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 189-189, 2006.

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P2K-07 Centrally applied GLP-1 activates the sympatho-adrenomedullary outflow by brain prostaglandin-mediated mechanisms in rats

Junichi Arai, Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Liany Lu, Kumiko Nakamura, Mieko Yorimitsu, Kunihiko Yokotani
Dept. neuropharmacol. , Neural Integration, Grad. Sch. of Medicine, Kochi Univ. , Nankoku Okoutyou Kohasu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 190-190, 2006.

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P2K-08 Effect of substance P (1-7) on the release of glutamate and nitric oxide evoked by intrathecal administration of capsaicin

Mika Sasaki1, Takaaki Komatsu1, Shinobu Sakurada2, Tsukasa Sakurada1
1Dept. Biochem. , Daiichi Coll. Pharmaceu. Sci. , Fukuoka, Japan,, 2Dept. Physiol. Anat. , Tohoku Pharmaceu. Sci. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 190-190, 2006.

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P2K-09 Molecular and pharmacological characterization of primate NK1 and NK3 tachykinin receptors in the central nervous system of the rhesus monkey

Masatoshi Nagano1, Fumihito Saitow1, Eisuke Haneda1, Shiro Konishi2, Motoharu Hayashi3
1Dept. Pharmacol. , Nippon Medical School, Tokyo, Japan,, 2Waseda-Olympus Biosci Res Instit, Waseda Univ. , Singapore,, 3Dept. Cell Mol Biol, Primate Res Instit, Kyoto Univ. , Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 190-190, 2006.

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P2K-10 Increase in galanin gene expression in hypothalamic dorsomedial nucleus by fasting

Tomohiro Shiiya, Takeshi Niki, Hiroshi Higuchi
Div. Pharmacol. , Niigata Univ. , Grad Sch. , Med. Dent. Sci. , Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 190-190, 2006.

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P2K-11 Regulation of neuropeptide gene expression by fasting in NPY-Y1 receptor knock out mice

Takeshi Niki, Tomohiro Shiiya, Hiroshi Higuchi
Div. Pharmacol. , Mol. Cell. Med. , Niigata Univ. Grad Schl. Med. Dent. Sci. , Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 191-191, 2006.

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P2K-12 Mapping of single amino acid residues required for G protein activation by the rat melanin-concentrating hormone receptor

Kei Maruyama1, Seiji Saito2, Mitsue Nakano1, Yoshimi Aizaki1, Ayumu Yoshikawa1, Kensaku Imai2, Hirofumi Doi2, Yumiko Saito1
1Dept. Pharmacol. , Saitama Med. Sch, Saitama,, 2Celestar Lexico-Sciences Inc, Makuhari techno Garden , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 191-191, 2006.

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P2K-13 Studies on drug dependence (Rept. 417): Changes in β-endorphin (β-EP)-containing neurons in the process of less liability of morphine dependence under a neuropathic pain-like state

Keiichi Niikura, Minoru Narita, Michiko Narita, Yasuyuki Nagumo, Tsutomu Suzuki
Dept. Toxicol. , Hoshi Univ. Sch. Pharm. Pharmaceut. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 191-191, 2006.

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P2K-14 Effects of lobeline on metham-phetamine-induced stereotyped behaviors and brain monoamine turnover in mice

Tomohiro Tatsuta1, 2, Nobue Kitanaka1, Junichi Kitanaka1, Yoshio Morita2, Motohiko Takemura1
1Dept. Pharmacol. , Hyogo Col. Med. , Nishinomiya, Japan,, 2Dept. Neuropsychiat. , Hyogo Col. Med. , Nishinomiya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 191-191, 2006.

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P2K-15 Decreased striatal dopamine level accompanied by the increase in the duration of the stereotypy after treatment with 2-phenylethylamine in combination with /-deprenylin mice

Junichi Kitanaka, Nobue Kitanaka, Tomohiro Tatsuta, Motohiko Takemura
Dept. Pharmacol. , Hyogo Col. Med. , Nishinomiya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 192-192, 2006.

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P2K-16 Fluoxetine as a potential pharma-cotherapy for methamphetamine dependence

Yukio Takamatsu1, Hideko Yamamoto1, Yasukazu Ogai1, Yoko Hagino1, Markou Athina2, Kazutaka Ikeda1
1Div. Psychobiol. , Tokyo Inst. Psychiatry. , Tokyo, Japan, ,, 2Mol. Integrative Neurosci. Dept. , The Scripps Res. Inst. , La Jolla, USA
Journal of Pharmacological Sciences 100 (suppl.2) 192-192, 2006.

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P2K-17 Effect of a selective 5-HT1A agonist tandospirone on abnormal involuntary move-ments in rat L-DOPA-induced dyskinesia model

Tadashi Ishibashi, Osamu Konishi, Nobumasa Takasugi, Akira Ito
Discov. Pharmacol. Gr. II, Pharmacol. Res. Lab. , Dainippon Sumitomo Pharma Co. , Ltd. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 192-192, 2006.

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P2K-18 Proteomic study on brain disrupting actions caused by prenatal diethylstilbe-strol exposure in mice

Motoaki Kawano, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Environ. & Molec. Health Sci. , Grad. Sch. Pharm. Sci. , Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 192-192, 2006.

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P2K-19 Prostaglandin E2 potentiates D1R signaling via EP1

Shiho Kitaoka1, 2, Sho Koyasu1, Yasuhiro Tanaka1, Akinori Nishi4, Tomoyuki Furuyashiki3, Toshiyuki Matsuoka1, Masayuki Miyasaka2, Shuh Narumiya1
1Dept. Pharmacol. , Kyoto Univ. Fac. Med. , Kyoto, Japan,, 2Dept. Micro biol. and Immunol. , Osaka Univ. Fac. Med. , Osaka, Japan,, 3Dept. Psycho. , Johns Hopkins Univ. , Baltimore, Maryland, USA,, 4Dept. Physio. Kurume Univ. Sch. Med, Kurume, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 193-193, 2006.

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P2K-20 Repeated exposure to metham-phetamine elicits synaptic plasticity in rat mesolimbic slice culture

Takehiko Maeda, Wakako Hamabe, Yohji Fukazawa, Kazumasa Kumamoto, Lu Qing Shang, Akihiro Yamamoto, Shiroh Kishioka
Lu Qing Shang, Akihiro Yamamoto, Shiroh KishiokaDept. Pharmacol. , Wakayama Med. Univ. , Wakayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 193-193, 2006.

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P2K-21 Human dopamine transporter iso-form produced by alternative splicing

Shigeo Kitayama1, Chieko Mitsuhata2, Chiharu Sogawa1, Norio Sogawa1, Katsuyuki Kozai2, Katsuya Morita3, Toshihiro Dohi3
1Dept. Dent. Pharmacol. , Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci. , Okayama, Japan,, 2Dept. Ped. Dent. , Hiroshima Univ. Grad. Sch. Biomed. Sci. , Hiroshima, Japan,, 3Dept. Dent. Pharmacol. , Hiroshima Univ. Grad. Sch. Biomed. Sci. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 193-193, 2006.

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P2K-22 Non-enzymatic metabolites of DOPS can induce DOPAergic responses

Reina Aoki1, Tatsurou Yagami1, Yoshinobu Sugiyama1, Yasuhiro Kajihara2, Naoki Yamamoto2, Yoshio Goshima1
1Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. Grad. Sch. Med. , Yokohama, Japan,, 2Dept. System Function, Yokohama City Univ. Grad. Sch. Integ. Sci. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 193-193, 2006.

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P2K-23 Amperometric detection and characterization of exocytotic events in single ventral midbrain dopaminergic neurons

Satoshi Yamada, Mizuki Sekiguchi, Norie Murayama, Nobuyuki Sasakawa, Konosuke Kumakura
Lab. Neurochem, and Neuropharmacol. , Life Sci. Insti. , Sophia Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 194-194, 2006.

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P2K-24 Activation of dopamine D4 receptors is protective against hypoxia-reoxy-genation-induced cell death in HT22 cells

Saori Shimada, Kumiko Ishige, Motoki Arakawa, Yoshihisa Ito
Dept. of Pharmacol. , Coll. of Pharm. , Nihon Univ. , Funabashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 194-194, 2006.

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P2K-25 The acute treatment of morphine augments the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain

Shigeru Takahashi1, Masanobu Yoshikawa1, Hidehiro Andoh2, Kenji Ito3, Toshiyasu Suzuki3, Mitsuru Kawaguchi4, Hiroyuki Kobayashi1, Tetsuo Oka1, Atsushi Hashimoto1
1Dept. Pharmacol. , Tokai Univ. Sch. Med. , Kanagawa, Japan,, 2Dept. Psychiatry, Tokai Univ. , Sch. Med. , Kanagawa, Japan,, 3Dept. Anesthsiol. Tokai. Univ. , Sch. Med. , Kanagawa, Japan,, 4Dept. Pharmacol. , Tokyo Dental College, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 194-194, 2006.

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P2K-26 Accumbal shell adrenoceptors differentially modulate dopamine and acetyl-choline receptor-mediated turning behaviour

Shoko Moribe, Hiroko Ikeda, Michiko Stou, Ayako Kotani, Noriaki Kosikawa
Dept. Pharmacol. , Nihon Univ. Sch. Dent. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 194-194, 2006.

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P2K-27 Novel and potent poly (ADP-ribose) polymerase-1 inhibitors, quinazoli-none and quinoxaline derivatives, ameliorate dopaminergic neuronal damage in mice models of Parkinson's disease

Akinori Iwashita1, Kayoko Mihara1, Shunji Yamazaki1, Shigeru Matsuura1, Junya Ishida2, Hirofumi Yamamoto2, Kouji Hattori2, Nobuya Matsuoka1, Seitaro Mutoh1
1Neuroscience, Pharmacology Research Labs. , Astellas Pharma Inc. , Ibaraki, Japan,, 2Chemistry Research Labs. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 195-195, 2006.

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P2K-28 Role of nitric oxide system in stri-atal hydroxyl radical production in carbon monoxide poisoned rats

Shuichi Hara1, Toshiji Mukai2, Kunihiko Kurosaki3, Hajime Mizukami1, Fumi Kuriiwa1, Takahiko Endo1
St. Marianna Univ. Sch. Med. , Kanagawa, Japan,, 3Dept. Legal Med. , Toho Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 195-195, 2006.

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P2K-29 The role of histamine H3 receptors in reward and locomotor sensitization induced by psychostimulants in mice

Tomohiro Okuda, Nobuyuki Okamura, Hongmei Dai, Ajing Xu, Motohisa Kato, Kazuhiko Yanai
Dept. Pharmacol. , Tohoku Univ. Sch. Med. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 195-195, 2006.

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P2K-30 Effect of nicotine on the priming stimulation effect of intracranial self-stimulation reward in rats

Hidenori Sagara, Yoshihisa Kitamura, Kazuhiko Shibata, Yutaka Gomita
Department of Hospital Pharmacy, Okayama University Medical and Dental School, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 195-195, 2006.

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P2K-31 Influence of amantadine and memantine on MAO activity, monoamine uptake and 5-HT-induced head-twitch response in mouse

Seiichiro Ishigaki1, Yuichiro Arai1, Osamu Nakagawasai2, Yumiko Arai3, Takeshi Tadano2, Hajime Yasuhara1
1Dept. Pharmacol. , Showa Univ. Sch. Med, Tokyo, Japan,, 2Dept. Pharmacol. , Tohoku Pharmaceut. Univ. , Sendai, Japan,, 3JAPIC, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 196-196, 2006.

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P2K-32 Double-transplantation of mouse embryonic stem cell-derived neurons and behavioral recovery in hemiparkinsonian rats

Yoshihisa Kitamura, Masatoshi Inden, Takashi Taniguchi
Dept. Neurobiol. , 21st Century COE Program, Kyoto Pharm. Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 196-196, 2006.

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P2K-33 The effect of entacapone, a catec-hole-O-methyltransferase inhibitor, on motor activity and striatal dopamine levels in a rat model of Parkinson disease induced by Japanese encephalitis virus

Mutsuko Terado1, Naoya Hamaue2, Akihiko Ogata3, Kosei Ohno1, Masahiko Hirafuji2, Kunio Tashiro4, Hiroko Togashi1
1Dept. Clin. Physiol. , Fac. of Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 2Dept. Pharmacol. , Fac. of Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 3Dept. Neurol. , Grad. Sch. Med. , Hokkaido Univ. , Sapporo, Japan,, 4Sch. of Psycol. Sci. , Health Sci. Univ. of Hokkaido, Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 196-196, 2006.

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P2K-34 The neuronal mechanism of ORL1 receptor agonist W-212393 -induced non-photic entrainment of circadian clock

Ayumi Uchida1, Kazuko Miyakawa1, Tomomi Shiraki2, Koji Teshima3, Shigenobu Shibata1, 2
1Dept. Elec. Eng. & Biosci. , Sch. Sci. & Eng. , Waseda Univ. , Tokyo, Japan,, 2Dept. Basic Human Sci. , Sch. Human Sci. , Waseda Univ. , Nishitokyo, Japan,, 3Res. Lab. I, Phar. Res. Un. , R&D Div. Mitsubishi Pharma Corp. , Yokohama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 196-196, 2006.

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P2K-35 No effect of ORL1 receptor ago-nist W-212393 on light-induced phase shifts of circadian clock

Tomomi Shiraki1, Kazuko Miyakawa2, Ayumi Uchida2, Koji Teshima3, Hiroshi Takeshima4, Shigenobu Shibata1, 2
1Dept. Basic Human Sci. , Sch. Human Sci. , Waseda Univ. , Nishitokyo, Japan,, 2Dept. Elec. Eng. & Biosci. , Sch. Sci. & Eng. , Waseda Univ. , Nishitokyo, Japan,, 3Res. Lab. I, Phar. Res. Un. , R&D Div. Mitsubishi Pharma Corp. , Yokohama, Japan,, 4Dept. Biochem. , Grad. Sch. Med. , Tohoku Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 197-197, 2006.

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P2K-36 Role of serotonin2 receptors in methamphetamine-induced behavioral sen-sitization in mice

Naoko Kajita1, Yukio Ago2, Shigeo Nakamura1, Soichi Itoh1, Akemichi Baba2, Toshio Matsuda1
1Lab. Medicinal Pharmacol. , Grad. Sch. Pharm. Sci. , Osaka Univ. , Osaka, Japan,, 2Lab. Mol. Neuropharmacol. , Grad. Sch. Pharm. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 197-197, 2006.

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P2K-37 Inhibition of D1-like dopamine receptor signaling by expression of the third intracellular loop domain of the D1 receptor

Akinori Nakajima, Hisashi Mori
Dept. Mol. Neurosci. , Toyama Univ. Grad. Sch. Med. and CREST/JST, Toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 197-197, 2006.

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P2K-38 SKF83959 regulates DARPP-32 phosphorylation by activating PLC-dependent and independent cascades

Mahomi Kuroiwa, Akinori Nishi, Masatoshi Tanaka
Dept. Pharmacol. , Kurume Univ. Sch. Med. , Kurume, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 197-197, 2006.

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P2K-39 Effect of cannabinoid receptor lig-ands on 3-nitropropionic acid-induced dopamine release in rat striatum

Takashi Uezono, Yuki Ono, Shigeto Suzuki, Ryo Kaijima, Kageyoshi Ono, Junichi Kurihara
Dept. Pharmacol. , Fac. Pharm. Sci. , Teikyo Univ. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 198-198, 2006.

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P2K-40 Characterization of dopaminergic neurons in flatworm planarian and development to unique medicines

Kaneyasu Nishimura1, Yoshihisa Kitamura1, Takeshi Inoue2, Yoshihiko Umesono2, Shozo Sano2, Masatoshi Inden1, Kanji Yoshimoto3, Kiyokazu Agata2, Takasi Taniguchi1
1Dept. Neurobiol. , 21st Century COE Program, Kyoto Pharm. Univ. , Kyoto, Japan,, 2RKEN CDB, Kobe, Japan,, 3Dept. Legal Med. , Kyoto Prefectural Univ. of Med. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 198-198, 2006.

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P2K-41 Alteration of bradykinesia and striatal serotonin level in a rat model of Parkinson disease induced by Japanese encephalitis virus

Naoya Hamaue1, Mutsuko Terado2, Kenji Iizuka1, Kosei Ohno2, Kunio Tashiro3, Hiroko Togashi2, Masahiko Hirafuji1, Akihiko Ogata4
1Dept. Pharmacol. , Fac. of Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 2Dept. Clin. Physiol. , Fac. of Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 3Sch. of Psycol. Sci. , Health Sci. Univ. of Hokkaido, Sapporo, Japan,, 4Dept. Neurol. , Hokkaido Univ. Grad. Sch. of Med. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 198-198, 2006.

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P2K-42 Role of DARPP-32 Thr34 phos-phorylation in methamphetamine-induced behavioral sensitization

Takahide Shuto1, 2, Akinori Nishi1, Tsuneyuki Yamamoto2, Masatoshi Tanaka1
1Dept. Pharmacol. , Kurume Univ. Sch. Med, Kurume, Japan,, 2Dept. Pharmacol. , Grad. Sch. Pharm. Sch. Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 198-198, 2006.

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P2K-43 Effects of thiotepa on the polyamine concentration in regional brain of rats

Satoru Watanabe1, Seitaro Ohkuma1, Shoichi Sato2, Sumika Nagase2
1Dept. of Pharmacol. , Kawasaki Med. Sch. , Okayama, Japan,, 2Dept. of Med. Tech. Kawasaki College of Allied Health Professions, Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 199-199, 2006.

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P2K-44 P2Y6 receptor mediates the con-stitutive pinocytosis in astrocytes

Kaoru Nasu-Tada1, Hidetoshi Tozaki-Saitoh1, 2, Kazuhide Inoue2, Schuichi Koizumi1
1Div. Pharmacol. , Natl. Inst. Hlth. Sci. , Tokyo, Japan,, 2Dept. Mol. Sys. Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 199-199, 2006.

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P2K-45 Modulation of P2 receptor-mediated signaling by lipopolysaccharide in rat astrocytes

Satoko Ohkubo, Kaoru Nasu-Tada, Hidetoshi Tozaki-Saitoh, Schuichi Koizumi
Div. Pharmacol. , Natl. Inst. Hlth. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 199-199, 2006.

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P2K-46 The identification of a microplatform that mediates K+ and water transports in brain astrocytes

Hiroshi Hibino, Chizuru Tsuzuki, Hiromi Nakao, Yoshihisa Kurachi
Div. Mol. Cell. Pharmacol. , Dept. Pharmacol. , Osaka Univ. Sch, Med. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 199-199, 2006.

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P2K-47 Polysulfides induce calcium waves in rat hippocampal astrocytes

Yasuo Nagai1, Mamiko Tsugane1, 2, Jun-ichiro Oka2, Hideo Kimura1
1Dept. Mol. Genetics, Nat'l. Inst. Neurosci. , NCNP, Tokyo, Japan,, 2Lab. Pharmacol. , Fac. Pharm. Sci. , Tokyo Univ. Sci. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 200-200, 2006.

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P2K-48 Evaluation of pentosan polysulfate for the permeability of blood-brain barrier

Mayu Hagihara1, Hideki Shuto1, Fuyuko Takata1, 5, Susumu Shirabe2, 5, Shinsuke Nakagawa3, 5, Maria A Deli4, 5, Masami Niwa3, 5, Yasufumi Kataoka1, 5
1)Dept. Pharm. Care Health Sci. , Fac. Pharm. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 2)1st Dept. Int. Med. , Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 3)Dept. Pharmacol. 1, Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 4)Hungarian Academy Sci. , Szeged, Hungary,, 5)PhamamaCo-Cell Inc. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 200-200, 2006.

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P2K-49 Inhibition of a glial K+ channels by a tricyclic antidepressant, nortriptyline

Suwen Su, Atsushi Inanobe, Christoph Lossin, Hiroshi Hibino, Yoshihisa Kurachi
Dept. Pharmacol, Osaka Univ. Sch. Med, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 200-200, 2006.

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P2K-50 Protective effect of ATP on oxidative damage of astrocytes in rat hippocam-pal cultures

Takumi Fujita, Yusuke Yamamura, Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyusyu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 200-200, 2006.

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P2K-51 Upregulation of microglial P2X4 receptors by retinoic acid

Hidetoshi Tozaki-Saitoh1, 2, Makoto Tsuda2, Schuichi Koizumi1, Kazuhide Inoue2
1Div. Pharmacol. , Natl. Inst. Hlth. Sci. , Tokyo, Japan,, 2Dept. Mol. Sys. Pharmacol. , Grad. Sch. Pharmaceut. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 201-201, 2006.

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P2K-52 α7 nicotinic acetylcholine receptors modulate microglial function via a phos-pholipase C/IP3 pathway

Chihiro Hama1, Kana Harada1, Kanako Miyano1, Hiroaki Matsubayashi2, Norio Sakai2, Izumi Hide1, Yoshihiro Nakata1
1Dept. Pharmacol. , Grad. Sch. Biomed. Sci. , Hiroshima Univ. , Hiroshima, Japan,, 2Dept. Mol. Pharmacol. Neurosci. , Grad. Sch. Biomed. Sci. , Hiroshima Univ. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 201-201, 2006.

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P2K-53 Phosphorylation of MLC by Rho kinase is involved in lysophosphatidic acid-induced reversal of stellation in rat astrocytes

Yuri Ikeda-Matsuo1, Emi Yatsuzuka1, Yasuhito Naito1, Yoh Takuwa2, Hiroshi Hosoya3, Yasuharu Sasaki1
1Lab. Pharmacol. , Sch. Pharmac. Sci. , Kitasato Univ. , Tokyo, Japan,, 2Dept. Physiol. , Kanazawa Univ. Grad. Sch. Med. , Ishikawa, Japan,, 3Dept. Biol. Sci. , Grad. Sch. Sci. , Hiroshima Univ. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 201-201, 2006.

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P2K-54 Protection by antidiarrheic ingredi-ents against cell death in cultured astrocytes

Nobuyuki Matsushima1, 2, Takeshi Takarada1, Katsura Takano1, Yuki Kambe1, Yukio Yoneda1
1Lab. Mol. Pharmacol. , Kanazawa Univ. Grad. Sch. Nat. Sci. Tech. , Ishikawa Japan,, 2Taiko Pharmaceutical Co. , Ltd, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 201-201, 2006.

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P2K-55 Activation of microglia by suba-cute treatment with LPS leads to the decrine of NMDA receptors

Toshiomi Shibutani1, Sachiko Tanaka1, Hirokazu Ohtaki2, Seiji Shioda2, Satoshi Numazawa1, Takemi Yoshida1
1Dept. Biochem. Toxicol. , Showa Univ. Sch. Pharmceu. Sci. , Tokyo, Japan,, 2Dept. Anat. , Showa Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 202-202, 2006.

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P2K-56 Effect of purine and pyrimidine nucleosides on basal and hydrogen peroxide-induced thymidine incorporation into cultured astrocytes

Koh-ichi Tanaka, Tomoaki Sato, Yoshiko Ohnishi, Takashige Nishikawa
Dept. Applied Pharmacol. , Kagoshima Univ. Grad. Sch. Med. & Dent. Sci, Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 202-202, 2006.

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P2K-57 Regulation of the blood brain barrier function with 17β -estradio

Chiasa Hirakawa1, Fuyuko Takata1, 4, Hideki Shuto1, Shinsuke Nakagawa2, 4, Maria A Deli3, 4, Masami Niwa2, 4, Yasufumi Kataoka1, 4
1Dept. Pharm. Care Health Sci. , Fac. Pharm. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 2Dept. Pharmacol. 1, Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 3Hungarian Academy Sci. , Szeged, Hungary,, 4PharmaCo-Cell Inc. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 202-202, 2006.

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P2K-58 Glucose regulated blood-brain barrier transport of insulin: Pericyte-astro-cyte-endothelial cell cross talk

Ryota Nakaoke1, 2, 3, Verma Sulekha3, Maria A Deli4, Susumu Shirabe1, Masami Niwa2, Banks Willam A.3
1)1st Dept. Internal Medicine, Nagasaki Univ. Sch. Med. , Nagasaki, Japan,, 2)Dept. Pharmacology, Nagasaki Univ. Sch. Mcd, Sakamoto Nagasaki ,, 3)Div. Geriatrics, Dept. Internal Medicine, St. Louis Univ. Sch. Mcd, St. Louis, USA,, 4)Biological Research Center, Szeged, Hungary
Journal of Pharmacological Sciences 100 (suppl.2) 202-202, 2006.

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P2K-59 Quinidine blocks the astroglial inward-rectifier Kir4.1

Christoph Lossin1, Hiroshi Hibino1, Atsushi Ishii2, Shinichi Hirose2, Yoshihisa Kurachi1
1Dept. Pharmacol. , Osaka Univ. Sch. Med. , Osaka, Japan,, 2Dept. Pediatrics, Fukuoka Univ. , Sch. Med. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 203-203, 2006.

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P2K-60 Hepatocyte growth factor (HGF) enhances barrier function of the blood-brain barrier (BBB)

Shinsuke Nakagwa1, 4, Kenzou Hazama1, 2, Kunihiko Tanaka1, 4, Shinya Dohgu2, Fuyuko Takata2, 4, Maria A Deli3, 4, Yasufumi Kataoka2, 4, Masami Niwa1, 4
1Dept. Pharmacol. 1, Nagasaki Univ. Grad. Sch. Biomed. Sci. , Nagasaki, Japan,, 2Dept. Pharm. Care Health Sci. Fac. Pharm. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 3Hungarian Academy Sci. , Szeged, Hungary,, 4PharmaCo-Cell Inc. , Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 203-203, 2006.

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P2K-61 Nicotine improves short-term memory deficit induced by domoic acid, an amnesic shellfish poison, in mice

Ken-ichi Ueno1, Hiroshi Ogawa1, Yukiharu Sawada1, Hiroko Togashi2
1Dept. Food & Drug, Hokkaido Inst. Public Health, Sapporo, Japan,, 2Dept. Clin. Physiol. , Fac. Pharm. Sci. , Health Sci. Univ. Hokkaido, Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 203-203, 2006.

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P2K-62 Volatile female odors activate the accessory olfactory system of male mice without physical contact

Yoshikage Muroi1, Toshiaki Ishi1, 2, Seiich Komori1, 3, Masakazu Nishimura1, 2
1Dept. Pathogenetic. , Gifu Univ. Graduate Sch. Vet. , Gifu, Japan,, 2Dept. Pathobiological. , Obihiro Univ. Sch. Vet. , Obihiro, Japan,, 3Dept. Vet. Med. , Gifu Univ. Sch. Vet. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 203-203, 2006.

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P2K-63 Participation in GABA neurons of the medial septal area on radial maze performance in rats

Yasuko Yamamoto, Yoko Fujii, Chiaki Kamei
Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 204-204, 2006.

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P2K-64 Observation of drug-induced dis-ruption of fine motor control in monkeys (2nd report)

Masahiko Iino, Yoshio Wakasa, Atsushi Fujiwara, Takahiro Ohtsuka, Mitsuru Hoshino
Pharmacol. & Toxicol. , Dept. Ina Research Inc. , Nagano, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 204-204, 2006.

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P2K-65 Effect of repeated valproate and diazepam treatment on contextual fear conditioning-induced behavioral changes in mice

Song Li1, 2, Yukihisa Murakami1, Minwei Wang2, Kinzo Matsumoto1
1Div. Medicinal Pharmacol. , Inst. Natural Medicine, Univ. of Toyama, Toyama, Japan,, 2Dept. Pharmacol. , Shenyang Pharm. Univ. , Shenyang, China
Journal of Pharmacological Sciences 100 (suppl.2) 204-204, 2006.

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P2K-66 Safety pharmacological property of intrathecal baclofen in rats

Miho Kuroiwa, Akemi Nakada, Kiyoshi Takasuna, Yutaka Kitano
New Product Research Laboratories II, R&D Division, Daiichi Pharmaceutical Co. , Ltd. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 204-204, 2006.

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P2K-67 Behavioral characterization of the object location test in mice

Takeshi Murai, Shoki Okuda, Takeshi Tanaka, Hisashi Ohta
CNS Disorder Research, Tsukuba Research Institute, Banyu Pharmaceutical Co. , Ltd. , , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 205-205, 2006.

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P2K-68 Antagonist of NMDA receptor attenuated jumping behaviors of PACAP-deficient mice

Naofumi Kawagishi, Takeshi Shimada, Akiko Yamamoto, Kazuhiro Tanaka, Mariko Kuroda, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba
Lab. Mol. Neuropharmacol. , Grad. Sch. of Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 205-205, 2006.

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P2K-69 Role of hippocampal extracellular signal-regulated kinase (ERK1/2) phosphory-lation in spatial working memory

Misato Dohniwa1, Taku Nagai1, Masanori Takayanagi1, Kana Kobayashi1, Kazuhiro Takuma1, Toshitaka Nabeshima2, Kiyofumi Yamada1
1Lab. Neuropsychopharmacol. , Div. Life Sci. , Grad. Sch. Nat. Sci. Technol. , Kanazawa Univ. , Kanazawa, Japan,, 2Dept. Neuropsychopharmacol. Hosp. Pharm. , Nagoya Univ. Grad. Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 205-205, 2006.

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P2K-70 Changes in cortical synaptic transmission during extinction of contextual fear in freely moving rats

Machiko Matsumoto1, 2, Hiroyo Koseki1, Hiroko Togashi2, Riki Hirata1, Taku Yamaguchi1, Yu Ohomura1, Mitsuhiro Yoshioka1
1Dept. Neuropharmacol. , Hokkaido Univ. Grad. Schi. Med. , Sapporo, Japan,, 2Dept. Clin. Physiol. , Facul. Pharm. Sci. , Hokkaido Health Sci. Univ. , Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 205-205, 2006.

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P2K-71 Role of Piccolo in long-term potentiation and spatial memory

Daisuke Ibi1, Atsumi Nitta2, Kumiko Ishige1, Xiaobo Cen2, Toshitaka Nabeshima2, Yoshihisa Ito1
1Dept. of Pharmacol. , Coll. of Pharm. , Nihon Univ. , Funabashi, Japan,, 2Dept. Neuropsychopharmacol. and Hosp. Pharm. , Nagoya Univ. Grad. Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 206-206, 2006.

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P2K-72 Vasopressin V1 a receptor knock-out mice exhibit impairment of social behavior

Nobuaki Egashira1, Akito Tanoue2, Tomomi Matsuda1, Hiroko Fuchigami1, Gozoh Tsujimoto3, Kenichi Mishima1, Katsunori Iwasaki1, Michihiro Fujiwara1
1Dept. Neuropharmacol. , Fac. Pharm. Sci. , Fukuoka Univ. , Fukuoka, Japan,, 2Dept. Mol. Cell Pharmacol. , Natl. Res. Inst. Child Health Develop. , Tokyo, Japan,, 3Dept. Genom. Drug Discov. Sci. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 206-206, 2006.

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P2K-73 A possibility of cyclooxygenase participation in the NC-1900-induced improvement on learning and memory in mice

Tomoaki Sato1, Takayuki Ishida1, 2, Koh-ichi Tanaka1, Yoshiko Ohnishi1, Kenji Hirate3, Takashige Nishikawa1
1Dept. Applied Pharmacol, Kaoshima Univ. Grad. Sch. Med. & Dent. Sci. , Kagoshima, Japan,, 2Dept. Oral Maxillofacial Surg. , Kaoshima Univ. Grad. Sch. Med. & Dent. Sci. , Kagoshima, Japan,, 3Research Lab. , Nippon Chemiphar Co. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 206-206, 2006.

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P2K-74 Altered synaptic transmission in APPswe and PS1 double transgenic mice

Yasuaki Goto1, Tetsuhiro Niidome1, Ken Shimono2, Nobuhiko Taniuchi1, Yasuo Mori3, Takeshi Kihara1, Hachiro Sugimoto1
1Dept. of. Neurosci. Drug Discov. , Grad. Sch. Pharmaceutical Sci. , Kyoto Univ. , Kyoto, Japan,, 2Alpha MED Sciences CO. , LTD. , Osaka, Japan, Osaka, Japan,, 3Dept. Synth. Biol. Chem. , Facult. Eng. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 206-206, 2006.

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P2K-75 Mechanism of adenosine-induced hypothermia during entrance phase of hiber-nation in Syrian hamsters

Mitsuteru Shintani1, Yutaka Tamura2, Junichi Kato2, Mayuko Monden2, Hirohito Shiomi2
1Research Center for Green Sci. Fukuyama Univ. , 1, Hiroshima, Japan,, 2Depart. Pharmacol. Faculty of Pharmacy and Pharmaceutical Sci. Fukuyama Univ. , 1, Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 207-207, 2006.

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P2K-76 Inducible ablation of cerebellar granule cells by a CrePR-loxP recombination system

Takeshi Uemura1, Toshio Ikeda2, Shigeyoshi Itohara2, Masayoshi Mishina1
1Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan,, 2Behavioral Genetics, Brain Sci Inst, RIKEN, Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 207-207, 2006.

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P2K-77 Influences of epidermal growth factor (EGF) overexpression on mouse behavior

Takeyoshi Eda1, Makoto Mizuno1, 2, Hiroyuki Aoki1, Siu-Yuen Chan3, Hiroyuki Nawa1
1Dept. of Mol. Neurobiol. , Brain Res. Institute, Niigata Univ. , Niigata, Japan,, 2Ctr. for Transdisciplinary Res. , Niigata Univ. , Niigata, Japan,, 3Dept. of Pediat. Sch. Med. Hong Kong Univ. , Hong Kong
Journal of Pharmacological Sciences 100 (suppl.2) 207-207, 2006.

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P2K-78 Neurobiological basis of isolation induced-ultrasonic vocalization in a rat pup

Satoko Ise, Hisashi Ohta, Norihiro Nagano
CNS Disorder Research, Tsukuba Research Institute, Banyu Pharmaceutical Co. , Ltd. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 207-207, 2006.

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P2K-79 Fisetin, a flavonoid, facilitates the induction of long-term potentiation in the CA1 region of rat hippocampal slices and memory for object recognition in mice

Tatsuhiro Akaishi1, Pamela Maher2, Kazuho Abe1
1Lab. Pharmacol. , Fac. Pharm. & Res. Inst. Pharmaceut. Sci. , Musashino Univ. , Tokyo, Japan,, 2Cell. Neurobiol. Lab. , Salk Inst. , USA
Journal of Pharmacological Sciences 100 (suppl.2) 208-208, 2006.

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P2K-80 Effects of oral administration of crocetin on diazepam-induced impairment of amygdalo-hippocampal long-term potentiation and anti-convulsive action

Kazuho Abe1, Yu-Mei Jin2, Naofumi Umigai1, 3, Takahisa Nakano3, Takashi Kahara3, Masahiro Takahashi3, Miwa Misawa2
1Lab. Pharmacol. , Fac. Pharm. , Musashino Univ. , Tokyo, Japan,, 2Dept. Pharmacol. , Sch. Pharm. , Hoshi Univ. , Tokyo, Japan,, 3Dept. Health Care, Riken Vitamin Co. Ltd. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 208-208, 2006.

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P2K-81 Mechanisms of enhanced excitation in mutant mice lacking NMDA receptors selectively in the hippocampal CA3 region

Fumiaki Fukushima1, Toru Shinoe2, Masahiro Fukaya3, Hirotaka Kataoka1, Masahiko Watanabe3, Toshiya Manabe2, Masayoshi Mishina1
1Dept. Mol. Neurobiol. and Pharmacol. , Grad. Sch. of Med. , Uni. of Tokyo and SORST/JST, Tokyo, Japan,, 2Div. Neuronal Network, Dept. of Basic Med. Sci. , Inst. of Med. Sci. , Univ. of Tokyo, Tokyo, Japan,, 3Dept. Anat. , Sch. of Med. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 208-208, 2006.

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P2K-82 Separation-induced ultrasonic vocalization in rat pups: Further pharmaco-logical characterization

Michihiko Iijima, Shigeyuki Chaki
Med. Res. Labs, Taisho Pharmaceutical Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 208-208, 2006.

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P2K-83 Antidepressant and anxiolytic effects of a nonpeptidic MCH1R antagonist, ATC0218

Akie Ito1, Toshiharu Shimazaki1, Michihiko Iijima1, Mariko Nishiguchi1, Takeo Funakoshi1, Andrew Grottick2, William Thomsen2, Kosuke Kanuma1, Katunori Omodera1, Yoshinori Sekiguchii1, Thuy-Anh Tran2, Graeme Semple2, Shigeyuki Chaki1
1Med. Res. Labs. , Taisho Pharmaceutical Co. , Ltd. , Saitama, Japan,, 2Arena Pharmaceuticals, Inc. , San Diego, USA
Journal of Pharmacological Sciences 100 (suppl.2) 209-209, 2006.

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P2K-84 Effect of pyrilamine on the hip-pocampal theta wave during radial maze performance in rats

Takayoshi Masuoka, Azusa Mikami, Yoko Fujii, Chiaki Kamei
Depart. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 209-209, 2006.

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P2K-85 Ameliorating effects of GLP-1 on lipopolysaccharide-induced memory impair-ment in mice

Kahori Tanimitsu, Takashi Iwai, Jun-ichiro Oka
Lab. Pharmacol. , Fac. Pharm. Sci. , Tokyo Univ. Science, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 209-209, 2006.

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P2K-86 Ethanol facilitates reconsolidation process in contextual fear memory

Hiroshi Nomura, Norio Matsuki
Lab. Chem. Pharmacol. , Grad. Sch. Pharm. Sci. , Univ. Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 209-209, 2006.

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P2K-87 Nobiletin with CRE-dependent transcription-stimulating activity improves MK-801 -induced impairment of learning and memory in mice

Akira Nakajima1, Tohru Yamakuni1, Norihito Nakata1, Kentaro Matsuzaki1, Akihito Yokosuka2, Yutaka Sashida2, Yoshihiro Mimaki2, Yasushi Ohizumi
1Dept. Pharmaceutical Molecular Biology, Tohoku Univ. Grad. Sch. Pharm. , Sendai, Japan,, 2Lab of Medicinal Plant Sci. Sch. Pharm. Tokyo Univ. of Pharm and Life Sci, Hachioji, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 210-210, 2006.

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P2L-01 Role of NADPH oxidase in the pathogenesis of DOCA-salt-induced hyper-tension

Aya Fujii
Dept. Pharmacol. , Osaka Univ. Pharmaceut. Sci. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 210-210, 2006.

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P2L-02 Augmentation of intrarenal angiotensin II levels in aldosterone-induced hypertensive rats

Yu-Yan Fan, Akira Nishiyama, Shoji Kimura, Yukiko Nagai, Youichi Abe
Dept. Pharmacol. , Kagawa Univ. Med. Sch. , Kagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 210-210, 2006.

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P2L-03 Mechanism of the onset of diabetic nephropathy in type 2 diabetic db/db mice (1st report)

Makoto Hosoyamada, Mai Suzuki, Masaki Kimura, Toshiaki Shibasaki
Dept. Pharmacotherapeutics, Kyoritsu Univ. Pharmacy, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 210-210, 2006.

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P2L-04 Nephroprotective effect of Pioglitazone in Zucker fatty rats

Yasushi Hirasawa1, 2, Yukari Matsui1, Shin-ya Yabuki1, Tohru Toyoshi1, Masanori Ito2, Yoshiteru Tanaka2, Tadashi Nagamatsu2
1Nihon Bioresearch Inc. , Gifu, Japan,, 2Department of Pharmacology, Faculty of Pharmacy, Meijo University. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 211-211, 2006.

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P2L-05 Changes of RhoA and RhoB proteins in ischemic acute renal failure

Junpei Mutoh, Masahiro Ohsawa, Hiroaki Hisa
Second Dept. Pharmacol. , Kyushu Univ. Health and Welfare, Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 211-211, 2006.

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P2L-06 Effect of agmatine in ischemic acute renal failure rats

Takahiro Sugiura, Hidenobu Tsutsui, Kentaro Hayashi, Masanori Takaoka, Yasuo Matsumura
Dept. Pharmacol. , Osaka Univ. Pharmaceut. Sci. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 211-211, 2006.

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P2L-07 Preventive effect of moxonidine on ischemia/reperfusion-induced renal injury in rats

Hidenobu Tsutsui, Takahiro Sugiura, Kentaro Hayashi, Masanori Takaoka, Yasuo Matsumura
Dept. Pharmacol. , Osaka Univ. Pharmaceut. Sci. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 211-211, 2006.

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P2L-08 Induction of the intestinal oligopeptide transporters in puromycin-induced nephrotic syndrome in rats

Tomoe Fujita1, Shuichi Yasuda2, Machiko Ozaki3, Yuji Kumagai1, Masataka Majima1, Yoshio Ohtani3
1Dept. Pharmacol. , Kitasato Univ. Sch. Med. , Kanagawa, Japan,, 2Analysis Cent. Integral Genomic Functions, Kitasato Univ. Sch. Med. , Kanagawa, Japan,, 3Clinical Investigation Cent, Kitasato East Univ. Hospital, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 212-212, 2006.

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P2L-09 Transdifferentiation of renal epithelial tubular cells induced by albumin-bound oleic acid

Yosuke Mabuchi2, Ryoji Kojima1, Mikio Ito1, 2
1Analytical Pharmacol. , Fac. of Pharmacy, Nagoya, Japan,, 2Meijo University Graduate School of Environmental and Human Sciences, Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 212-212, 2006.

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P2L-10 Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity

Anri Baba1, Misaki Matsuo1, Takahisa Yano2, Yoshinori Itoh2, Toshiaki Sendo2, Ryozo Oishi2
1Grad. Sch. pharmacy. sci. , Kyushu Univ. , Fukuoka, Japan,, 2Dept. Pharmacy, Kyushu Univ. Hosp. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 212-212, 2006.

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P2L-11 Involvement of cholesterol in production of initial glycated amadori-protein

Masayoshi Ito, Yasushi Hirasawa, Natsuko Hiroyama, Tadashi Nagamatsu
Dept. Phamacobiology and therapeutics, Meijo Univ. Shc. Pharm. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 212-212, 2006.

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P2L-12 Probenecid inhibits calcium oscil-lations in MDCK cells

Takashi Udagawa1, 2, Kazushige Hanaoka2, Chikara Otsubo1, Tatsuo Hosoya2, Masahiro Kawamura1
1Department of Pharmacology, Jikei University School of Medicine, Tokyo, Japan,, 2Division of Kidney and Hypertension, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 213-213, 2006.

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P2L-13 Roles of altered arginase activity and nNOS protein expression for the impaired neurogenic relaxation of carpus cavernosum in the aged rabbit

Noboru Numao1, Yasuyuki Sakai1, Hitoshi Masuda1, Youhei Okada1, Kazunori Kihara1, Hiroshi Azuma2
1Department of Urology, Tokyo Medical and Dental University, Tokyo, Japan,, 2Department of Biosystem Regulation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 213-213, 2006.

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P2L-14 Examination on benign prostatic hyperplasia in non-human primate

Teruo Susumu, Haruno Yonamine, Tetsuya Yoshikawa, Yuki Akiyoshi, Ryoichi Nagata, Go Kito
Shin Nippon Biomedical Laboratories (SNBL), Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 213-213, 2006.

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P2L-15 Real-time monitoring of nitric oxide and blood flow during ischemia-reper-fusion in the rat testis

Tomoharu Kono, Motoaki Saito, Yukako Kinoshita, Itaru Satoh, Chiko Shinbori, Keisuke Satoh
Dept. of Pathophysiological and Therapeutic Sci. , Div. of Mol. Pharmacol. , Tottori Univ. Faculty of Med. , Yonago, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 213-213, 2006.

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P2L-16 Mechanism underlying the dimethyl sulfoxide (DMSO)-induced relaxation of the rabbit detrusor smooth muscle

Kenichiro Shiga, Jyunji Nishimura, Naohisa Niiro, Mayumi Hirano, Katsuya Hirano, Hideo Kanaide
Div. Mol. Cardiol. , Res. Inst. Angiocardiol. , Grad. Sch. Med. Sci, Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 214-214, 2006.

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P2L-17 Temperature-dependent actions of flavoxate hydrochloride on voltage-dependent L-type Ca2+, currents in human detrusor myocytes

Toshihisa Tomoda1, 2, Noriyoshi Teramoto1, Narihito Seki2, Seiji Naito2, Yushi Ito1
1Dept. Pharmacol. , Med. Sch. , Kyushu Univ. , Fukuoka, Japan,, 2Dept. Urol. , Med. Sch. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 214-214, 2006.

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P2L-18 Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes

Manami Aishima1, Noriyoshi Teramoto1, Toshihisa Tomoda1, Takakazu Yunoki2, Toshiaki Nakano3, Narihito Seki2, Yoshikazu Yonemitsu3, Katsuo Sueishi3, Seiji Naito2, Yushi Ito1
1Dept. Pharmacol. , Kyushu Univ. Sch. Med. , Fukuoka, Japan,, 2Dept. Urol. , Kyushu Univ. Sch. Med. , Fukuoka, Japan,, 3Dept. Pathol. , Kyushu Univ. Sch. Med. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 214-214, 2006.

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P2L-19 Urethral responses to electrical stimulation of pelvic nerve and capsaicin in male and female rats

Kazuumi Ishida, Naoki Aizawa, Yuuki Matsutani, Satoko Kimura, Satoshi Takeno, Hitoshi Kontani
Dept. Pharmacol. , Fac. Pharm. Sci. , Hokuriku Univ. , Ishikawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 214-214, 2006.

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P2L-20 Investigation of conscious and unrestricted cystometry in mice

Nahoko Maeda, Ryouji Mizumachi, Hiroshi Atai, Katsuhide Nishi
Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 215-215, 2006.

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P2L-21 The role of TRPV4 as a flow sensor in the fow-dependent K+ secretion in the cortical collecting duct

Junichi Taniguchi1, Shuichi Tsuruoka2, Atsuko Mizuno1, Jun-ichi Satoh1, Akio Fujimura2, Makoto Suzuki1
1Div. Mol. Pharmacol. , Dept. Pharmacol. , Jichi Medical School, Tochigi, Japan,, 2Div. Clin. Pharmacol. , Dept. Pharmacol. , Jichi Medical School, Tochigi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 215-215, 2006.

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P2L-22 Transporter-mediated toxicity of cephaloridine and ochratoxin A assessed by DNA microarray analysis

Promsuk Jutabha, Tomoko Muto, Hitoshi Endou, Yoshikatsu Kanai
Dept. Pharmacol. Toxicol. , Kyorin Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 215-215, 2006.

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P2L-23 Inhibitory effect of resveratrol, a phytoestrogen, on catecholamine synthesis in cultured bovine adrenal medullary cells

Yuko Shinohara, Yumiko Toyohira, Minhui Liu, Kazumi Tanaka, Susumu Ueno, Masato Tsutsui, Nobuyuki Yanagihara
Dept. Pharmacol. , Univ. of Occupational and Environmental Health, Sch. Med. , Kitakyushu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 215-215, 2006.

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P2L-24 Effect of orchidectomy on silde-nafil-induced flushing of tail skin in mice

Kohta Shibuya, Munehiko Ikeda, Fuyuko Takata, Hideki Shuto, Yasufumi Kataoka
Dept. Pharm. Care Health Sci. , Fac. Pharm. Sci. , Fukuoka Univ, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 216-216, 2006.

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P2L-25 IGF binding protein-7 modulates steroidogenesis in ovarian granulosa cells

Mayumi Matsushita, Kazuhiro Tamura, Aiju Endo, Masahiko Kutsukake, Hiroshi Kogo
Dept. Endocrine Pharmacol. , Tokyo University Pharmacy & Life Science, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 216-216, 2006.

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P2L-26 Impaired glucose utilization in white adipose tissue of diet-induced obese mice and intervention using PPARγ agonist

Takashi Shirakura, Yukina Tokushima, Hiroyasu Hirose, Jun Suzuki
Banyu Pharmaceutical Co. , Ltd. , Tsukuba Res. Inst. , Tsukuba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 216-216, 2006.

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P2L-27 Expression of mRNA for APJ, an orphan GPCR, in adipose tissue of obesity-associated diabetic mice

Chie Ishida1, Atsushi Kasak1, Norihito Shintani1, Hitoshi Hashimoto1, Toshio Matuda2, Akemichi Baba1
1Lab. Mol. Neuropharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 2Lab. Medicinal Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 216-216, 2006.

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P2L-28 Mild electrical stimulation with hyperthermia up-regulates heat shock protein 72 expression and ameliorates hyper-glycemia in mice model of type 2 diabetic

Saori Morino1, Tatsuya Kondo2, Kazunari Sasaki2, Takeomi Yasuda2, Erika Sekimoto1, Eiichi Araki2, MaryAnn Suico1, Tsuyoshi Shuto1, Tsukasa Okiyoneda1, Hirofumi Kai1
1Dept. Mol. Med. , Fac. Med. Pharm. , Kumamoto Univ. , Kumamoto, Japan,, 2Dept. Met. Med. , Grad. Sch. Med. , Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 217-217, 2006.

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P2L-29 Analysis for functional roles of vasopressin receptors in releasing growth hormones

Jun-ichi Birumachi, Akito Tanoue
Dept. Pharmacol. , Natl. Res. Inst. Child Health Develop. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 217-217, 2006.

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P2L-30 Tissue distribution of L-cysteine-metabolizing enzymes possibly involved in the production of hydrogen sulfide

Yukiko Kaneko1, Toshihide Kimura1, Hideo Kimura2, Ichiro Niki1
1Dept. Pharmacol. , Oita Univ. Faculty Med. , Oita, Japan,, 2Dept. Mol. Genetics, National Inst. of Neuroscience. , NCNP, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 217-217, 2006.

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P2L-31 A murine model of Graves' disease applicable to analysis for new anti-thy-roid drugs and their evaluation

Tetsuya Fuse, Toshio Kaneda, Atsushi Hakozaki, Asako Honda, Kentarou Tsuboi, Urara Yamamoto, Akihiro Mutou, Tadashi Yoshida
Dept. of Pathophysiology, Faculty of Pharmaceutical Sci. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 217-217, 2006.

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P2L-32 Substrate recognition mechanisms of a novel cationic amino acid transporter CAT5

Yuewei Li1, Masami Kanai2, Taku Hirata1, Naohiko Anzai1, Hayato Kawakami2, Hitoshi Endou1, Yoshikatsu Kanai1
1Dept. Pharmacol. Toxicol. , Kyorin Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Anat. , Kyorin Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 218-218, 2006.

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P2L-33 Effects of angiotensin II receptor blockers on genetically diabetic mice

Yukari Matsui, Yasushi Hirasawa, Shoko Otsu, Youko Ozeki, Takahiko Nagase, Miwa Tomioka, Tohru Toyoshi
Nihon Bioresearch Inc. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 218-218, 2006.

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P2L-34 Development of the simple and sensitive detection system for the estrogen-like substances used human cell culture

Tatsuo Hamazaki1, Toshio Hongo2
1Dept. Tissue Regeneration, Res. Inst. , Internatl. Med. Cen. Japan, Tokyo, Japan,, 2Tokyo Med Dent Univ, Grad. Sch. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 218-218, 2006.

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P2L-35 Differential roles of 5-HT2 receptor subtypes on m-CPP-induced ejaculatory response in male rats

Masaru Yoshizumi1, Akihiko Yonezawa1, Manabu Ebiko1, Yukio Kimura2, Shinobu Sakurada1
1Dept. Physiol. Anat. , Tohoku Pharmaceut. Univ. , Sendai, Japan,, 2Towada Urology, Towada, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 218-218, 2006.

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P2L-36 Gestational changes in arginase activity for regulating myometrial contractions in the rat

Misako Hirata1, Shuichi Sakamoto1, Satoshi Obayashi1, Takeshi Aso1, Hiroshi Azuma2
1Comprehensive Reproductive Medicine, Grad. sch. , Tokyo Medical & Dental Univ. , Tokyo, Japan,, 2Dept. of Biosystem Regulation, Institute of Biomaterials & Bioengineering, Grad. sch. , Tokyo Medical & Dental Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 219-219, 2006.

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P2L-37 Participation of adenosine receptors in the ADP- and ATP-induced relaxations in the corpus cavernosum penis of rabbits

Katsuo Furukawa1, Kazuyoshi Kataoka2, Nobuhisa Ishii2, Hiromichi Tsuru1
1Dept. Pharmacol. , Fac. Med. Toho Univ. , Tokyo, Japan,, 2Dept. Urol. Fac. Med. Toho Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 219-219, 2006.

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P2M-01 Combination therapy of an ARB with a statin exerts additive cardioprotection through inhibition of reactive oxygen species in Dahl salt-sensitive rats

Eiichiro Yamamoto, Shokei Mitsuyama
Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 219-219, 2006.

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P2M-02 In vitro and in vivo electrophysio-logical effects of D2 receptor antagonists in isolated ventricular myocytes and anes-thetized guinea pigs

Nobuo Homma, Amran MohammadShah, Keitaro Hashimoto
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 219-219, 2006.

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P2M-03 Evaluation of effects of drugs regarding QT interval prolongation by ex vivo action potential duration assay

Yasunori Negishi, Junko Suzuki, Takeshi Miyamori, Fuminori Matsubara, Hiroaki Takahashi, Akihiro Kannou, Yuji Tsurubuchi
Pharmacological Research Laboratories Drug Safety Testing Center Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 220-220, 2006.

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P2M-04 Evaluation of Geldanamycin-induced blockade of hERG trafficking

Youko Sasaki, Makoto Hiroyasu, Seiichi Katayama, Mayumi Obo, Kentaro Ando
Pharmacology Division, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 220-220, 2006.

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P2M-05 Geranylgeranylation of RhoB in Na+/Ca2+ exchanger mRNA increase by lisophosphatidylcholine in H9c2 cells

Sachiko Maeda, Isao Matsuoka, Junko Kimura
Dept. Pharmacol. , Sch. Med. , Fukushima Med. Univ. , Fukushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 220-220, 2006.

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P2M-06 Olmesartan suppresses hypoxia-induced left ventricular remodeling in apolipoprotein E-knockout mice

Chika Yamashita1, Tetsuya Hayashi2, Tatsuhiko Mori2, Koichi Sohmiya2, Nobuaki Okuda2, Yoshikatsu Okada3, Yasushi Kitaura2, Daisuke Nakano1, Michiko Oda1, Yasuo Matsumura1
1Dept. Phannacol. , Osaka Univ. Pharmaceut. Sci. , Osaka, Japan,, 2Third Dept. Med. , Osaka Med. Col. , Takatsuki, Japan,, 3Dept. Pathol. , Osaka Med. Col. , Takatsuki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 220-220, 2006.

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P2M-07 Effects of drugs affecting the QT-intervals on ECG recorded in dogs under anesthetic and conscious conditions

Kazuaki Sasaki, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi
Department of Pharmacology. , Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 221-221, 2006.

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P2M-08 Inhibitory effects of dronedarone and amiodarone on HERG+KvLQT1/minK currents

Ikuo Norota, Kazue Nakashima, Kuniaki Ishii
Dept. Cardiovasc. Pharmacol. , Yamagata Univ. Sch. Med. , Yamagata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 221-221, 2006.

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P2M-09 Extracellular acidosis attenuates the ventricular repolarization delay by pharmacological IKr blockade assessed using the Langendorff-perfused guinea-pig heart

Yuji Nakamura, Atsushi Sugiyama, Akira Takahara, Keitaro Hashimoto
Dept. Pharmacol. , Univ. Yamanashi, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 221-221, 2006.

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P2M-10 Assessment of cardiac function using echocardiography in the rat

Yoshiki Sanzen1, Mikio Nakazawa1, Tomie Kawada2, Hiroshi Sato3
1Dept. Med. Technol. , Sch. Health Sci. , Fac. Med. , Niigata Univ. , Niigata, Japan,, 2Dept. Clin. Pharmac. , Fac. Pharm. , Musashino Univ. , Tokyo, Japan,, 3Div. Pharmac. , Niigata Univ. Hosp. , Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 221-221, 2006.

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P2M-11 Action potential properties of the myocardium from chronic AV block dogs (2): Atria and pulmonary vein

Hideaki Nouchi1, Toshikazu Tanaka1, Hideki Nakamura1, Hikaru Tanaka1, Akira Takahara2, Atsushi Sugiyama2, Keitaro Hashimoto2, Koki Shigenobu1
1Department of Pharmacology, Toho University School of Pharmaceutical Science, Funabashi, Japan,, 2Dept. Pharmacol. , Univ. of Yamanashi, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 222-222, 2006.

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P2M-12 Action potential properties of the myocardium from chronic AV block dogs (1): right ventricle and Purkinje fiber

Hideki Nakamura1, Takeshi Tamura1, Toshikazu Tanaka1, Hideaki Shimada1, Miku Tamura1, Noriko Tsuruoka1, Kentaro Takeda1, Hideaki Nouchi1, Hikaru Tanaka1, Akira Takahara2, Atsushi Sugiyama2, Keitaro Hashimoto2, Koki Shigenobu1
1Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Japan,, 2Dept. Pharmacol. , Univ. of Yamanashi, Yamanashi Japan
Journal of Pharmacological Sciences 100 (suppl.2) 222-222, 2006.

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P2M-13 Effects of thiopental on muscarinic potassium currents in atrial cells from guinea pig

Maki Kimura, Kosuke Oyama, Saki Misono, Yasunori Momose
Dept. Pharmacotherapy, Toho Univ. Sch. Pharm, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 222-222, 2006.

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P2M-14 R(-)-efonidipine, a selective T-type calcium channel blocker, inhibits the progression of monocrotaline-induced right ven-tricular hypertrophy in rats

Norio Hashimoto, Norihisa Ishiwata, Nobutomo Tsuruzoe
Biological Research Laboratories, Nissan Chemical Industries, Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 222-222, 2006.

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P2M-15 Preventive effects of coenzyme Q10 against increased oxidative stress in rats with metabolic syndrome

Yu Yamaguchi1, Noriko Yoshikawa1, Atsuko Harada1, Satomi Kagota1, Jun Haginaka2, Kazuki Nakamura1, Masaru Kunitomo1
1Dept. Pharmacol. , Sch. Pharmaceu. , Mukogawa Women's Univ. , Nishinomiya, Japan,, 2Dept. Anal. Chem. , Sch. Pharmaceu. , Mukogawa Women's Univ. , Nishinomiya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 223-223, 2006.

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P2M-16 Modeling of the inactivation process of L-type Ca2+ channel

Shingo Suzuki1, Ian Findlay2, Yoshihisa Kurachi3
1Clinical Genome Informatics Centre, Kobe Univ. Sch. Med. , Kobe, Japan,, 2Tours Univ. , Tours, France,, 3Osaka Univ. Sch. Med. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 223-223, 2006.

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P2M-17 Reduction of myocardial infarct size by tetrahydrobiopterin: Possible involve-ment of mitochondrial KATP channels activation through nitric oxide production

Teruaki Wajima, Shunichi Shimizu, Masakazu Ishii, Yuji Kiuchi
Dept. Pathophysiol. , Sch. Pharm. Sci. , Showa Univ, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 223-223, 2006.

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P2M-18 A novel monkey proarrhythmia model that can predict the drug-induced tor-sades de pointes in clinical practice

Yoshioki Satoh1, 2, Atsushi Sugiyama1, 3, Akira Takahara1, Kengo Sakamoto4, Mitsugu Sakamoto4, Mamoru Nomura4, Keitaro Hashimoto1
1Dept. Pharmacol. , Univ. Yamanashi, Yamanashi, Japan,, 2Koshu Rehabilitation Hospital, Yamanashi , Japan,, 3Yamanashi Research Center Clin. Pharmacol. , Yamanashi, Japan,, 4Safety Research Center, Ina Research Inc. , Nagano, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 223-223, 2006.

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P2M-19 Characterization of SN-6, a novel benzyloxyphenyl derivative Na/Ca exchange inhibitor

Yasuhide Watanabe1, Chun-Feng Niu2, Takahiro Iwamoto3, Hiroshi Satoh2, Tsuyoshi Urushida2, Hideharu Hayashi2, Junko Kimura4
1Dept. Pathophysiol. , Basic Nursing, Hainamatsu Univ. Sch. Med. , Hamamatsu , Japan,, 2Dept. Int. Med. III, Hamamatsu Univ. Sch. Med. , Hamamatsu , Japan,, 3Dept. Pharmacol. , Fukuoka Univ. Sch. Med. , Fukuoka, Japan,, 4Dept. Pharmacol. , Fukushima Med. Univ. Sch. Med. , Fukushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 224-224, 2006.

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P2M-20 Intracellular mechanisms for the endothelin-induced negative and positive inotropy in adult mouse ventricle

Shinpei Fujiki1, Kentaro Takeda1, Rina Moriwaki1, Yoshiko Shimizu1, Akihiro Kazama1, Iyuki Namekata1, Toru Kawanishi2, Hikaru Tanaka1, Koki Shigenobu1
1Dept Pharmacol. , TOHO Univ. Sch. Pharm. , Chiba, Japan,, 2Division of BiologicalChemistry and Biologicals, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 224-224, 2006.

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P2M-21 Coassembly of KCNE1 alters the putative binding site of azimilide on KCNQ1 channels

Ryoko Niwa, Mikio Morishima, Haruo Honjo, Kaichiro Kamiya
Res. Inst. of Environment Med, Nagoya Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 224-224, 2006.

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P2M-22 Cloning of novel isoforms of murine cardiac calcium channel α1 subunit and their different binding affinities with β2 subunit

Manabu Murakami1, Takayosh Ohba2, Yoichiro Takahashi2, Kyoichi Ono1, Hiroyuki Watanabe2, Hiroshi Ito2, Toshihiko Iijima1
1Dept. Pharmacol. , Akita Univ. Sch. Med. , Akita, Japan,, 2Second Dept. of Internalmedicine Akita Univ. Sch. Med. , Akita, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 224-224, 2006.

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P2M-23 Facilitation of HERG channel can be induced by various HERG blockers

Miki Iwata1, Yukio Hosaka2, Yoshihisa Kurachi1
1Dept. Pharmacol. , Osaka Univ. Sch. Med. , Osaka, Japan,, 2Dept. Cardio. Nigata City Hospital, Nigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 225-225, 2006.

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P2M-24 Establishment of the cultivation system in sinoartrial node cells and maintenance of their genetic characters: Morphological changes and drug responsiveness

Sachiko Yamaguchi1, Tomonori Nakamura1, Shizuko Tsuchiya1, Shingo Yano1, Kageyoshi Ono2
1Lab. Mol. Pharmacol. Pharmacother. Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan,, 2Dept. Pharmacol. II, Fac. Pharm. Sci. , Teikyo Univ. , Sagamiko-machi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 225-225, 2006.

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P2M-25 Relationship between morphological change of the cardiomyocytes and intra-cellular calcium kinetics in doxorubicin-induced cardiomyopathy mouse model

Naomi Katayama1, Tomonori Nakamura1, Shizuko Tsuchiya1, Kageyoshi Ono2, Shingo Yano1
1Lab. Mol. Pharmacol. Pharmacother. Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan,, 2Dept. Pharmacol. II, Fac. Pharm. Sci. , Teikyo Univ. , Sagamiko-machi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 225-225, 2006.

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P2M-26 CaMKII and ERK activities mediate endothelin-1 -induced cardiac hypertro-phy in cultured rat cardiomyocytes

Yingmei Lu, Shinsaku Itoh, Jiro Kasahara, Kohji Fukunaga
Dept. Pharmacol. , Graduate School of Pharmaceutical Sciences. , Tohoku Univ. , Miyagi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 225-225, 2006.

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P2M-27 Positive inotropic effect of EGCg, a green tea cathechin, in guinea pig hearts: The measurements of cellular Ca2+ and NO release

Yoshihiro Hotta1, Lei Huang1, Tatsuya Muto1, Michio Yajima1, Kunihiro Miyazeki1, Yasushi Wakida1, Naohisa Ishikawa1, Akinobu Nakano2
1Dept. Pharmacol. , Aichi Med. Univ. Sch. Med. , Aichi, Japan,, 2Dept. Organ Pathology, Shimane Univ. Sch. Med. , Izumo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 226-226, 2006.

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P2M-28 Protease activated receptor-1 -mediated activation of focal adhesion kinase in rat cardiomyocytes

Hitomi Otani1, 2, Seijitsu Ando1, Yasuhiro Yagi2, Kanzo Kawai2, Hiroyuki Nishikawa2, Hiromasa Araki2, Chiyoko Inagaki1
1Dept. Pharmacol. , Kansai Medical Univ. , Osaka, Japan,, 2Res. Dev. Center, Fuso Pharmaceu. Ind. Ltd. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 226-226, 2006.

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P2M-29 S-nitrosylation of the slow activating delayed rectifier K+ channel by nitric oxide

Ken Asada, Junko Kurokawa, Tetsushi Furukawa
Dept. Bio-informational Pharmacol. , MRI, Tokyo Med. & Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 226-226, 2006.

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P2M-30 Paradoxical effects of endothelin-1 on myofilament Ca2+, sensitivity in twitch and tetanic contraction in mouse ventricular myocytes

Kazuhide Nishimaru, Yong Yang, Masao Endoh
Dept. Cardiovasc. Pharmacol. , Yamagata Univ. Sch. Med. , Yamagata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 226-226, 2006.

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P2M-31 Crebanine inhibits the L-type calcium current (/Ca,L) and the inwardly rectifying potassium current (/K1) in guinea pig ventricular myocytes: Relevance with antiarrhythmic action

Tomohiko Taniguchi1, Qing Lin2, Tomonori Nakamura1, Yosuke Fujioka1, Shizuko Tsuchiya1, Shingo Yano1, Kageyoshi Ono3
1Lab. Mol. Pharmacol. Pharmacother. Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan,, 2Dept. Pharmacol. , Sch. Chinese M. M. Sci. , Yunnan College TCM, China,, 3Dept. Pharmacol. II, Fac. Pharm. Sci. , Teikyo Univ. , Sagamiko-machi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 227-227, 2006.

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P2M-32 HTS screening of hERG blockers using 2nd-generation-automated patch-clamp system

Koji Nakano, Kenji Tsuzaki, Tomoko Tsuzaki, Yoshimi Katayama, Yuji Tsurubuchi
Drug Safety Testing Center Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 227-227, 2006.

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P2M-33 The effect of extracellular pH on the lkr and its blockers

Naoki Watanabe, Wen-ge Yu, Kana Kimura, Eri Noguchi, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi
Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 227-227, 2006.

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P2M-34 In vitro safety pharmacology assay using guinea pig cardiac myocyte

Yoshimi Katayama, Tomoko Tsuzaki, Taku Izumi, Satomi Tomizawa, Kanae Abe, Yuji Tsurubuchi
Pharmacological Research Laboratories, Drug Safety Testing Center Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 227-227, 2006.

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P2M-35 Effects of tanshinone VI on signal transduction in the facilitation of cardiac hypertrophy and fibrosis in vitro

Toru Arino1, Kouichi Tanonaka1, Yuji Kawahara1, Akira Yagi2, Satoshi Takeo1
1Dept. Mol. Cell. Pharmacol. , Tokyo Univ. Pharm. Life Sci. , Hachioji, Japan,, 2Pharm. Phrmaceut. Sci. , Fukuyama Univ. , Fukuyama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 228-228, 2006.

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P2M-36 Modulation of hERG and potency of its blockers by lowering the extracellular potassium concentration

Kana Kimura, Wen-ge Yu, Naoki Watanabe, Eri Noguchi, Mariko Yamaguchi, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi
Dept. of Pharmacology. , Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 228-228, 2006.

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P2M-37 Effects of imipramine on lkr of hERG/HEK293, lNa of isolated ventricular cells, and action potential of papillary muscle of the guinea pig

Wen-ge Yu, Tatsumi Inui, Kana Kimura, Naoki Watanabe, Eri Nuguchi, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nshi
Dept. Pharmacol. , Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 228-228, 2006.

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P2M-38 Effect of freeze-dried red wine on the coronary circulation of rats with cholesterol-rich diet

Yumi Katano1, Tomomi Aita1, Tomoko Shimoda1, Mikako Kaga1, Eri Murata1, Akiko Yamada1, Akira Ishihata2
1Div. Theoretic. Nurs. & Pathophysiol, Yamagata Univ. Sch. Med. , Yamagata, Japan,, 2Dept. Cardiovascular Physiol. , Yamagata Univ. Sch. Med. , Yamagata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 228-228, 2006.

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P2M-39 Effects of doxapram HCI on car-diac conduction system

Hiroko Nomura1, Tadayoshi Hata2, Yutaka Hirata3, Shunji Nagaoka1
1Dept. Physiol. , Fujita Health Univ. Sch. Health Sci. , Toyoake, Japan,, 2Dept. Clin. Pathophysiol. , Fujita Health Univ. Sch. Health Sci. , Toyoake, Japan,, 3Dept. Electronic. Eng. Chubu Univ. College of Eng. , Kasugai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 229-229, 2006.

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P2M-40 The usefulness of monophasic action potential and electrocardiogram measurement in the Langendorff-perfused guinea pig heart

Yumi Makita, Mototsugu Sakakibara, Kentaro Ando
Pharmacology Division, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 229-229, 2006.

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P2M-41 Involvement of voltage-dependent Ca2+ channel β3 subunit in sympathetic regulation of heart rate and contractility

Kyoichi Ono, Tsai-Wen Wu, Susumu Fujisawa, Manabu Murakami, Toshihiko Iijima
Dept. Pharmacol. , Akita Univ. Sch. Med. , Akita, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 229-229, 2006.

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P2M-42 Role of E-NTPDase1 /CD39 in ATP-induced modulation of norepinephrine exocytosis in heart

Takuji Machida1, 2, Paul M. Heerdt3, Alicia C. Reid4, Ulrich Schafer2, Randi B. Silver4, Masahiko Hirafuji1, M. Johan Broekman5, Aaron J. Marcus6, 7, Roberto Levi2
1Dept. Pharmacol. , Facul. Pharm. Sci. , Health Sci. Univ. of Hokkaido, Hokkaido, Japan,, 2Dept. Pharmacol. , Weill Cornell Med. Coll. , New York, USA,, 3Dept. Anesthesiol. , Weill Cornell Med. Coll. , New York, USA,, 4Dept. Physiol, and Biophys. , Weill Cornell Med. Coll. , New York, USA,, 5Med. -Hem/Onc. , Weill Cornell Med. Coll. , New York, USA,, 6Med. , -Hem/Onc, VA NYHHS, New York, USA,, 7Med. and Path. and Lab. Med. -Hem/Onc. , Weill Cornell Med. Coll. , New York, USA
Journal of Pharmacological Sciences 100 (suppl.2) 229-229, 2006.

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P2N-01 Analysis of the late asthmatic model animal using NC/Nga mice

Eiichi Araki, Kousuke Morizumi, Souta Ushijima, Hiroshi Atai, Katsuhide Nishi
Panapharrm Laboratories Co. , Ltd, Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 230-230, 2006.

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P2N-02 Development of alcohol-induced asthma model in mice

Souta Ushijima, Hiroshi Atai, Katsuhide Nishi
Panapharm Laboratories Co. , Ltd, Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 230-230, 2006.

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P2N-03 Analysis of different allergic reactions between two strains of mice

Juri Fukunaga1, 2, Masayoshi Abe1, Takeshi Katsuragi1, Mitsuo Takahashi2
1Dept. Clinical Pharmacol. , Fukuoka Univ. Pham. Sci, Fukuoka, Japan,, 2Dept. pharmacol. , Fukuoka Univ. Sch. Med, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 230-230, 2006.

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P2N-04 High sensitivity of mice by meas-urement of respiratory function using whole body plethysmography

Kazumi Hasegawa, Seiichi Katayama, Yoshinori Yamamoto, Kentarou Andou
Pharmacology Division, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 230-230, 2006.

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P2N-05 Pharmacological studies on a rat model of chronic obstructive pulmonary disease induced by cigarette smoke exposure

Maki Takahashi, Jun-ichi Fuchikami, Manami Chihara, Ai Saitou, Katsuo Ikezawa, Akiharu Fujino
Fuji Biomedix, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 231-231, 2006.

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P2N-06 Effects of codeine on capsaicin-or citric acid-induced coughs and sneezes in guinea-pigs

Motomu Tanaka, Kei Maruyama
Dept. Pharmacol. , Saitama. Med. Sch. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 231-231, 2006.

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P2N-07 Effect of serum thymic factor (FTS) on antigen induced early and late phase nasal blockage in a guinea pig model of allergic rhinitis

Jun-ichi Fuchikami1, Manami Chihara1, Maki Takahashi1, Ai Saitou1, Katsuo Ikezawa1, Akiharu Fujino1, Akira Awaya2
1Fuji Biomedix, Yamanashi, Japan,, 2Dermatology & Epidemiology Research Institute, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 231-231, 2006.

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P2N-08 Respiratory and lung changes by tobacco smoke exposure in mice

Kousuke Morizumi, Hiroshi Fujimura, Hiroshi Atai, Katsuhide Nishi
Panapharm Laboratories Co. , Ltd. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 231-231, 2006.

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P2N-09 Induction of apoptosis by the Asafoetida and its related compounds in Jurkat and HL-60 cells

Yasuo Kizawa1, Kosuke Shikata1, Ayako Banno1, Susumu Kitanaka2, Tadashi Kusama1
1Dept. Physiol. & Anat. , Nihon Univ. Coll. Pharm. , Chiba, Japan,, 2Lab. Pharmacog. & Nat. Prod. Chem. , Nihon Univ. Coll. Pharm. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 232-232, 2006.

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P2N-10 Nitric oxide decreases membrane water permeability and induces aquaporin-5 S-nitrosylation in lung epithelial cells

Kazufumi Nagai, Yoichiro Isohama, Akari Arimatsu, Akinori Hisatsune, Takeshi Miyata
Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 232-232, 2006.

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P2N-11 Pharmacological studies on the respiratory tract (Rept. 276): Interleukin-13 induces upregulation of RhoA protein in the bronchial smooth muscle in human and mice

Shuji Nakazawa, Yoshihiko Chiba, Hiroyasu Sakai, Miwa Misawa
Dept. Pharmacol. , Hoshi Univ. Sch. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 232-232, 2006.

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P2N-12 Pharmacological studies on the respiratory tract (Rept. 278): mRNA expression of NO synthase subtypes and augmentation of responsiveness to NO of nasal mucosa from nasal hyperresponsive rats

Jun Enzaka, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 232-232, 2006.

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P2N-13 Pharmacological studies on the respiratory tract (Rept. 279): Effect of lovas-tatin on augmented bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats

Junko Arima, Yoshihiko Chiba, Hiroyasu Sakai, Miwa Misawa
Department of Pharmacology, School of Phamacy, Hoshi University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 233-233, 2006.

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P2N-14 Pharmacological studies on the respiratory tract (Rept. 280): Upregulation of MMP12 in lungs of rats with allergic bronchial asthma

Yingyan Yu, Yoshihiko Chiba, Hiroyasu Saikai, Miwa Misawa
Dept. Pharmacol. , Sch. Pharm, Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 233-233, 2006.

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P2N-15 Involvement of P2X receptor sub-types in ATP-induced enhancement of the cough reflex sensitivity

Yoshiki Takahashi, Yuji Yoshikawa, Akiyoshi Saitoh, Junzo Kamei
Dept. of Pathophysiol. and Therap. , Sch. of Pharm. and Pharm. Sci. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 233-233, 2006.

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P2N-16 Protease-activated receptor 4-mediated increase in [Ca2+]i in cultured mouse lung epithelial cells

Seijitsu Ando1, Hitomi Otani1, Yasuhiro Yagi2, Akihiro Oshiro2, Kenzo Kwai3, Hiromasa Araki3, Chiyoko Inagaki1
1Dept. Phamacol. , Kansai medical Univ. , Osaka, Japan,, 2Dept. Internal. , Kansai Med. Univ. , Osaka, Japan, 3Res. Dev. Center, Fuso Pharmaceu. Ind Ltd. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 233-233, 2006.

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P2N-17 PAR2 signaling for production of IL-8 and prostaglandin E2 in human lung epithelial cells

Mami Nagataki1, Kazumi Moriyuki1, Fumiko Sekiguchi1, Hiroyuki Nishikawa2, Hiromasa Araki2, Atsufumi Kawabata1
1Div. Physio;. Pathophysiol. , Sci. Pharmaceut. Sci. , Kinki Univ, Higashi-Osaka, Japan,, 2Res. Dev. Center, Fuso Pharmaceu. Ind. Ltd, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 234-234, 2006.

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P2N-18 Effects of short-term proges-terone exposure on respiratory activity

Masahiko Suzuki1, Motomu Tanaka1, Shinichi Nakamura2, Kei Maruyama1
1Dept. Pharmacol. , Saitama Med. Sch. , Saitama, Japan,, 2Depts. Anesthesiol. , Saitama Med. Sch. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 234-234, 2006.

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P2N-19 NMDA mechanisms in depolarization of augmenting expiratory neurons during the expulsive phase of fictive cough in decerebrate cats

Akira Haji1, Yoshiaki Ohi2
1Lab. Neuropharmacol. , Sch. Pharm. , Aichi Gakuin Univ. , Nagoya, Japan,, 2Dept. Pharmacol. , Fac. Med. , Toyama Med. Pharmaceut. Univ. , Toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 234-234, 2006.

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P2N-20 Effects of ω1 subtype-selective hypnotic zolpidem on the activities in both hypoglossal and phrenic nerves in rabbits

Shinichi Nakamura1, Masahiko Suzuki2, Hiroshi Nagasaka3, Satoshi Mizukami1, Eiji Masaki1, Nobuyuki Matsumoto1, Kei Maruyama2, Hirosato Kikuchi1
1Dept. Anesth. , Saitama Med. Sch. , Saitama, Japan,, 2Dept. Pharmacol. , Saitama Med. Sch. , Saitama, Japan,, 3Dept. Anesth. Sch. Dent. , Meikai Univ. , Sakado, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 234-234, 2006.

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P2N-21 Effects of olmesartan, an AT1 receptor antagonist, on hypobaric hypoxia-induced activation of ERK1/2 and expression of IL-6 in mouse lung

Tomoaki Kitayama1, Yoshiyuki Tanabe1, Takao Kato1, Yuki Morikawa1, Kaori Iwata2, Hijiri Isobe2, Koichi Nakayama1
1Department of Molecular and Cellular Pharmacology, Graduate school of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan,, 2Biosafety Research Center, Foods, Drugs and Pesticides, Shizuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 235-235, 2006.

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P2N-22 Hydrogen sulfide, a novel endoge-nous gasomessenger, causes relaxation in mouse bronchial smooth muscle

Ichiko Doe, Satoko Kubo, Fumiko Sekiguchi, Atsufumi Kawabata
Div. Physiol. Pathophysiol. , Sch. Pharmaceut. Sci. , Kinki Univ. , Higashi-Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 235-235, 2006.

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P2N-23 Effects of phenol ethers, safrole and anethole, on the tracheal smooth muscle

Toru Kawasuji, Toshiyuki Matsubara, Hideyo Suzuki
Toyama Pref. Inst. for Pharm. Res. , Toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 235-235, 2006.

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P2N-24 Effect of H-1152 on the force produced by muscarinic receptor stimulation in rat bronchial smooth muscle

Motohiko Hanazaki1, Masataka Yokoyama1, Kiyoshi Morita1, Atsushi Kohjitani2, Yoshihiko Chiba3, Miwa Misawa3
1Dept. Anesthesiology, Okayama Univ. Med. Sch. , Okayama, Japan,, 2Dept. Dental Anesthesiology, Okayama Univ. Med. Sch. , Okayama, Japan,, 3Dept. Pharmacology, Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 235-235, 2006.

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P2N-25 Y-27632 augments the inhibitory effect of propofol in rat bronchial smooth muscle contraction

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P2N-26 PPAR γ partial agonist activity and PPAR α inverse agonist activity of capsaicin

Hiromi Yoshida1, Norimasa Tamehiro2, Tomoko Nishimaki-Mogami2, Kazuhide Inoue3, Yasuo Ohno4, Taku Nagao4, Yoji Sato1
1Div. Cell. Gene Thpy. Prod. , NIHS, Tokyo, Japan,, 2Dept. Biosignal. , NIHS, Tokyo, Japan,, 3Dept. Mol. Sys. Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Kyusyu Univ. , Fukuoka, Japan,, 4NIHS, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 236-236, 2006.

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P2N-27 Pathophysiological role of mast cells in scleroderma

Naotaka Shiota, Eiichi Kakizoe, Keiko Shimoura, Tetsuya Tanaka, Hideki Okunishi
Dept. Pharmacol. , Shimane Univ. Sch. Med. , Simane, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 236-236, 2006.

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P2N-28 Pharmacological studies on the pressure ulcer (Rept. 3): Changes in level of α1-acid glycoprotein and number of mast cells in pressure ulser of rats

Arina Kobayashi, Sayaka Kizaki, Hiroko Ushikubo, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 236-236, 2006.

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P2N-29 The development of new atopic dermatitis models in BALB/c mice

Rie Yatsuzuka, Chiaki Kamei
Dept. Med. Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. & Pharm. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 237-237, 2006.

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P2N-30 TPA-induced mast cell degranulation and the activation of pro-MMP-9 in mice

Yoshinori Iba, Maiko Shirai, Tohru Masukawa
Dept. Clin. Biochem. , Fac. Pharm. Sci. , Setsunan Univ. , Hirakata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 237-237, 2006.

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P2N-31 Crosstalk signaling between calcium-dependent and -independent pathways in thromboxane A2-induced fibroblast contraction in wound healing process

Hiroko Yoshida, Koji Nobe, Hiromi Nobe, Kazuo Honda
Dept. Pharmacol. , Showa Univ. Sch. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 237-237, 2006.

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P2N-32 Antinociceptive effect of spinally administered kyotorphin: Involvement of δ-opioid receptors

Takehiro Ochi, Yasuaki Shimizu, Seitaro Mutoh
Pharmacology Research Labs. , Drug Discovery Research, Astellas Pharma Inc. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 237-237, 2006.

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P2N-33 Antinociceptive effects of YM-230888, a potent, selective and orally-active antagonist of type 1 metabotropic glutamate receptors, at chronic pain models

Atsuyuki Kohara1, Yukinori Nagakura1, Tetsuo Kiso1, Takashi Toya1, Seiji Tamura1, Tomonari Watabiki1, Yoshitsugu Shitaka1, Hirotsune Itahana2, Masamichi Okada1
1Pharmacology Research Labs. , Astellas Pharma Inc, Ibaraki, Japan,, 2Chemistry Res. , Labs. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 238-238, 2006.

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P2N-34 Molecular cloning, functional characterization of the porcine TRPV1 (pTRPV1) and pharmacological comparison with endogenous pTRPV1

Toshio Ohta1, Ryuichi Komatsu1, Toshiaki Imagawa2, Kenichi Ostuguro1, Shigeo Ito1
1Lab. Pharmacol. , Grad. Sch. Vet. Med. , Hokkaido Univ. , Sapporo, Japan,, 2Biol. Chem. , Dev. Chem. , Grad. Sch. Sci. , Hokkaido Univ. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 238-238, 2006.

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P2N-35 Centrally-acting antitussives depress drug-induced hyperactivity in mice

Yoshiko Fujieda, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Environ. & Molec. Health Sci. , Grad. Sch. Pharm. Sci, Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 238-238, 2006.

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P2N-36 High frequency of ophthalmic malformation and altered thermal pain response in mice lacking apelin

Michiya Kakuda1, Atsushi Kasai1, Norihito Shintani1, Hitoshi Hashimoto1, Hideaki Katoh1, Toshio Matsuda2, Akemichi Baba1
1Lb. of Mol. Neuropharmacol. Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 2Med. Pharmacol. Grad. Sch. Pharmacceut. Sci. , Osaka Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 238-238, 2006.

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P2N-37 Triple histamine receptors genes knockout mice and their phenotypes

Eiko Sakurai, Atsuo Kuramasu, Feiyong Jia, Hongmei Dai, Motohisa Kato, Tomohiro Okuda, Kazuhiko Yanai
Dept. Pharmacol. , Tohoku Univ. Grad. Sch. Med. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 239-239, 2006.

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P2N-38 Key roles of complement activation and prostaglandin I2 for exudate formation in zymosan-induced mouse pleurisy

Koh-ichi Yuhki1, Hiroaki Naraba2, Shuh Narumiya3, Sachiko Oh-ishi4, Fumitaka Ushikubi1
1Dept. Pharmacol. , Asahikawa Med. Coll. , Asahikawa, Japan,, 2Pharmaceut. Res. Ctr. , Iwate Med. Univ. , Iwate, Japan,, 3Dept. Pharmacol. , Kyoto Univ. , Fac. Med. , Kyoto, Japan,, 4Basic Res. Div. , Kitasato Inst. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 239-239, 2006.

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P3K-01 Osmotic homeostasis mediated through urine outflow regulation by TRPV4 in the central nervous system

Hiromi Tsushima1, Mayumi Mori2
1Coll. Pharm. , Kinjo Gakuin Univ. , Nagoya, Japan,, 2Dept. Cell. Mol. Pharmacol. , Nagoya City Univ. Grad. Sch. Med. Sci. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 239-239, 2006.

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P3K-02 β-Neurexin selectively regulates synaptic vesicle accumulation in developing axon terminals of zebrafish olfactory sensory neurons in vivo

Yoshitsugu Masuda, Tomoyuki Yoshida, Masayoshi Mishina
Dept. of Mol, Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 239-239, 2006.

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P3K-03 Effects of geraniol, a herbal monoterpene alcohol, on cellular calcium mobilization

Masahiro Tanaka, Manabu Suzuki, Yohei Hayashi, Takashi Iwai, Jun-ichiro Oka
Lab. Pharmacol. , Fac. Pharm. Sci. , Tokyo Univ. Science, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 240-240, 2006.

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P3K-04 Involvement of ubiquitin-protea-some system in the cytotoxic effect of mutant protein kinase C gamma found in spinocerebellar ataxia type 14

Takahiro Seki1, Takayuki Shimahara1, Naoko Adachi2, Hiroaki Matsubayashi1, Taku Amano1, Naoaki Saito2, Norio Sakai1
1Dept. Mol. Pharmacol. Neurosci. , Grad. Sch. Biomed. Sci. , Hiroshima Univ. , Hiroshima, Japan,, 2Lab. Mol. Pharmacol. , Biosig. Res. Ctr, Kobe Univ. , Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 240-240, 2006.

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P3K-05 A possible role of hydrogen sul-fide as a synaptic modulator in rat hip-pocampal neurons

Mamiko Tsugane1, 2, Yasuo Nagai1, Takashi Iwai2, Jun-ichiro Oka2, Hideo Kimura1
1Dept. Mol. Genetics, Nat'l. Inst. Neurosci. , NCNP, Tokyo, Japan,, 2Lab. Pharmacol. , Fac. Pharm. Sci. , Tokyo Univ. Sci. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 240-240, 2006.

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P3K-06 Functions of histone deacetylase SIRT1 in undifferentiated neural cells

Shin Hisahara1, 2, Susumu Chiba2, Hiroyuki Matsumoto2, Yoshiyuki Horio1
1Dept. Pharmacol. , Sapporo Med. Univ. Sch. Med. , Sapporo, Japan,, 2Dept. Neurol. , Sapporo Med. Univ. Sch. Med. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 240-240, 2006.

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P3K-07 Estrogen enhances BDNF release from DG granule cells via classical ER-independent and PKA-dependent mechanisms

Kaoru Sato, Yasuo Ohno, Ken Nakazawa
Div. Pharmacol. , Natl. Inst. Hlth. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 241-241, 2006.

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P3K-08 Hepatocyte growth factor attenu-ates the decreases in the number of synapses after NMDA-induced excitotoxicity

Hiromi Akita1, Norio Takagi1, Hiroshi Funakoshi2, Kunio Matsumoto2, Toshikazu Nakamura2, Satoshi Takeo1
1Dept. Mol. Cell. Pharmacol. , Tokyo Univ. Pharm. Life Sci. , Tokyo, Japan,, 2Div. Mol. Regenerative Med. , Osaka Univ. Grad. Sch. Med. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 241-241, 2006.

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P3K-09 Effects of lipopolysaccharide on aquaporin expression in retinal Muller cells

Hideyuki Kobayashi1, Xiaoqiang Liu2, Hiroki Yokoo1, To Yanagita1, Nobuhisa Nao-i2, Akihiko Wada1
1Dept. Pharmacol. , Univ. Miyazaki, Miyazaki Med. Sch. , Miyazaki, Japan,, 2Dept. Opthalmol. , Univ. Miyazaki, Miyazaki Med. Sch. , Miyazaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 241-241, 2006.

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P3K-10 The localization and the dynamics of F-actin capping protein in hippocampal neurons

Takuma Kitanishi1, Shinich Kojima2, Jun Sakai2, Norio Matsuki1, Maki Yamada1
1Lab. Chem. Pharmacol. , Grad. Sch. Pharm. Sci. , Univ. of Tokyo, Tokyo, Japan,, 2Genomic Science Laboratories, Dainippon Sumitomo Pharma, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 241-241, 2006.

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P3K-11 Modulation of NR1/NR2A-subtype NMDA receptor channels by SAP102

Yasue Yamada, Makoto Inui
Dept. Pharmacol. Yamaguchi Univ. Sch. Med. , Yamaguchi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 242-242, 2006.

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P3K-12 DISC1 interacts with RNA-binding proteins in messenger ribonucleoprotein complex

Daisuke Tsuboi, Shinichiro Taya, Tomoyasu Shinoda, Takao Hikita, Setsuko Kuroda, Kozo Kaibuchi
Dept. of Cell Pharmacol. , Nagoya Univ. , Sch. Med. , Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 242-242, 2006.

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P3K-13 Drebrin-A closslinks F-actin, and inhibits the activity of myosin-V in vitro

Ryoki Ishikawa1, Ayumi Takahashi1, Nakamura Akio1, Yuki Hanyuda1, Kouji Oozeki2, Michitoshi Watanabe2, Michihiro Igarashi2, Kazuhiro Kohama1
1Dept. Mol. and Cell. Pharmacol. , Gunma Univ. Grad. Sch. Med. , Gunma, Japan,, 2Div. Mol, and Cell. Biol. , Grad. Sch. of Med. and Dent. Sci. , Niigata Univ. , Division of Molecular and Cellular Biology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 242-242, 2006.

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P3K-14 Tributyltin-induced Ca2+ mobilization via activation of L-type voltage-dependent Ca2+ channels in PC 12 cells

Masashi Okawa1, Toshihiro Unno1, Ryouko Iida1, Hayato Matsuyama1, Haruo Kobayashi2, Seiichi Komori1
1Lab. Pharmacol. , Dept. Vet Med. , Gifu Univ. , Gifu, Japan,, 2Dept. Vet Med. , Iwate Univ. , Iwate, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 242-242, 2006.

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P3K-15 Cadherin activity is required for activity-induced spine remodeling

Ko Okamura, Hidekazu Tanaka, Naomasa Miki
Dept. Pharmacol. , Med. Osaka Univ, Suita, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 243-243, 2006.

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P3K-16 Three kinds of modulations of P/Q-type (Cav2.1) Ca2+ channel activity by metabotropic glutamate receptor subtype 1a (mGluR1a)

Koji Yamazaki1, Minoru Wakamori1, Shigetada Nakanishi2, Yasuo Mori1
1Dept. Synthetic and Bio chem. , Kyoto Univ. Faculty. Eng. , Kyoto, Japan,, 2Osaka Bioscience Institute, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 243-243, 2006.

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P3K-17 Effect of HRD1 involved in endo-plasmic reticulum-associated degradation (ERAD) on degradation of amyloid precursor protein (APP) and suppression of beta amyloid (Aβ) production

Masayuki Kaneko1, 2, 3, Hiroshi Koike2, Karin Murahashi2, Tomohiro Omura2, Yasunobu Okuma1, 2, Yasuyuki Nomura1, 3
1Dept. Pharmacol. , Fac. Pharm. Sci. , Chiba Institute of Science, Chiba, Japan,, 2Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Hokkaido Univ. , Sapporo, Japan,, 3Hokkaido Univ. Grad. Sch. Med. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 243-243, 2006.

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P3K-18 Stimulation of GABAc receptors activated PKA through AKAP220

Li Yang, Yasuhisa Nakayama, Naoki Hattori, Chiyoko Inagaki
Dept. Pharmacol. , Kansai Med. Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 243-243, 2006.

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P3K-19 Phosphatidylinositol (Pl) protects amyloid β protein-induced neuronal death in a transgenic mouse expressing V337M human tau

Nan-yan Zhang, Kaori Kitagawa, Zheng-Mei Xiong, Chiyoko Inagaki
Dept. Pharmocol. , Kansai Med. Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 244-244, 2006.

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P3K-20 β subunits of voltage-gated sodi-um channels are novel substrates of β -site amyloid precursor protein-cleaving enzyme (BACE1) and γ -secretase

Takashi Sakurai1, Hon-Kit Wong1, Fumitaka Oyama1, Kumi Kaneko1, Koji Wada1, Haruko Miyazaki1, Masaru Kurosawa1, Bart De Strooper2, Paul Saftig3, Nobuyuki Nukina1
1Lab for Structural Neuropathology, RIKEN Brain Science Institute, Saitama, Japan,, 2Neuronal Cell Biol, CME, K. U. Leuven and V. I. B. , Leuven, Belgium,, 3Inst. Biochem. , Univ. Kiel, Kiel, Germany
Journal of Pharmacological Sciences 100 (suppl.2) 244-244, 2006.

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P3K-21 Enhancement of glutamate cyto-toxicity by Aβ25-35 via suppression of the Pl3K/Akt pathway in differentiated PC-12 cells

Yasuhisa Nakayama, Li Yang, Naoki Hattori, Chiyoko Inagaki
Dept. Pharmacol. , Kansai Med. Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 244-244, 2006.

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P3K-22 Mechanisms of endoplasmic reticulum stress-induced leptin resistant

Toru Hosoi1, Chie Hashimoto1, Michiko Yoshii1, Yasunobu Okuma2, Yasuyuki Nomura3, Koichiro Ozawa1
1Dept. Pharmacother. , Grad. Sch. Biomed. Sci. , Hiroshima Univ. , Hiroshima Kasumi, Japan,, 2Dept. Pharmacol. , Facul. Pharmaceut. Sci. , Chiba Inst. Sci. ,, 3Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Chiba, Japan, 3Daiichi Univ. , College Pharmaceut. Sci. , Daiichi University, College of Pharmaceutical Sciences, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 244-244, 2006.

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P3K-23 The NMDA receptor function is impaired by the disruption of actin binding protein drebrin A

Kenichi Kato, Nobuhiko Kojima, Tomoaki Shirao
Dept. Neurobiol. & Behav. , Gunma Univ. Grad. Sch. Med. , Maebashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 245-245, 2006.

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P3K-24 V-1, a novel regulatory protein of TH gene expression, serves as a cytoplasmic anchoring protein of CapZ to promote F-actin formation, resulting in the enhancement of maitotoxin-induced catecholamine secretion in PC12D cells

Atsushi Kakizaki1, 2, 3, Tohru Yamakuni1, Nobuaki Oka1, Masashi Kitazawa1, Eiichi Tachikawa2, Eiichi Taira2, Yoshikazu Miyate3, Katsuo Takahashi3, Toshifumi Yamamoto4, Yosuke Tojyo5, Yasush Ohizumi1
1Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan,, 2Department of Pharmacology, School of Medicine, Iwate Medical University, Morioka, Japan,, 3Department of Pharmacy, Iwate Medical University Hospital, Morioka, Japan,, 4Laboratory of Molecular Recognition, Graduate School of Integrated Science, Yokohama City University, Yokohama, Japan,, 5Department of Dental Pharmacology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 245-245, 2006.

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P3K-25 Developmental expression of zebrafish glutamate receptor δ2

Yoshinori Mikami1, Chiaki Sekine1, Hiroshi Sagara2, Tomoyuki Yoshida1, Masayoshi Mishina1
1Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan,, 2Lab. of Fine Morph. , Inst. of Medical Sci. , Univ. of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 245-245, 2006.

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P3K-26 Molecular cloning and expression patterns of zebrafish receptor protein tyrosine phosphatase σ

Xigui Chen, Yoshitsugu Masuda, Tomoyuki Yoshida, Masayoshi Mishina
Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 245-245, 2006.

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P3K-27 Molecular cloning and expression patterns of zebrafish SynCAM1 genes

Hiroe Tani, Tomoyuki Yoshida, Masayoshi Mishina
Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 246-246, 2006.

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P3K-28 Molecular cloning and expression pattern of zebrafish TM4SF2 gene

Naoki Tomita, Tomoyuki Yoshida, Masayoshi Mishina
Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 246-246, 2006.

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P3K-29 Impaired cerebellar climbing fiber innervation in the nervous system-specific FAK deficient mice

Fumihiro Watanabe1, Taisuke Miyazaki2, Masahiro Fukaya2, Tomonori Takeuchi1, Masahiko Watanabe2, Masayoshi Mishina1
1Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan,, 2Dept. Anato. , Hokkaido Univ. Sch Med, Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 246-246, 2006.

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P3K-30 Generation of TARP γ-2 (stargazin) conditional knockout mouse

Pyoung Hwa Lee1, Manabu Abe1, Maya Yamazaki1, Mika Tsujita2, Rie Natsume1, Kenji Sakimura1
1Dept. Cell. Neurobiol. , Brain Res. Inst. , Niigata Univ. , Niigata , Japan,, 2Center for Transdisciplinary Reseaech, Niigata University, Center Transdisciplinary. Res, Niigata Univ. , Japan
Journal of Pharmacological Sciences 100 (suppl.2) 246-246, 2006.

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P3K-31 Isolation of suppressor mutants from unc-51 and unc-14 mutants that have axon guidance defects

Hiroshi Matsuoka, Ken-ichi Ogura, Yoshio Goshima
Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. Grad. Sch. Med. , Yokohama
Journal of Pharmacological Sciences 100 (suppl.2) 247-247, 2006.

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P3K-32 Enhanced expression of RNase-L by glutamate in cultured cortical neurons

Chie Sugiyama, Kiyokazu Ogita
Dept. Pharmacol. , Setsunan Unive. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 247-247, 2006.

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P3K-33 Zebrafish GABAA receptor α6 subunit is expressed in three neural circuits showing characteristic cerebellum-like wiring

Chiaki Sekine, Yoshinori Mikami, Tomoyuki Yoshida, Masayoshi Mishina
Dept. of Mol. Neurobiol. and Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 247-247, 2006.

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P3K-34 Proteomic analysis of glutamate receptor δ2 mutant mice

Misato Yasumura, Takeshi Uemura, Masayoshi Mishina
Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 247-247, 2006.

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P3K-35 Distribution and protein levels of WASP family in brains of Alzheimer's disease

Daiju Tsuchiya1, Yoshihisa Kitamura1, Shun Shimohama2, Takashi Taniguchi1
1Dept. Neurobiol. , 21st Century COE Program, Kyoto Pharm. Univ. , Kyoto, Japan,, 2Dept. Neurol. , Grad. Sch. Med. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 248-248, 2006.

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P3K-36 Establishment of GluR δ2-tTA mouse line expressing tetracycline-controlled transactivator (tTA) selectively in cerebellar Purkinje cells

Eiko Kato1, Hisashi Mori1, Naoaki Saito2, Kenji Sakimura3, Masayoshi Mishina1
1Dept. of Mol. Neurobiol. & Pharmacol. , Grad. Sch. of Med. , Univ. of Tokyo and SORST/JST, Tokyo, Japan,, 2Lab. Mol. Pharmacol. , Biosignal Res. Ctr. , Kobe Univ. , Kobe, Japan,, 3Dept. of Cell. Neurobiol. , Brain Res. Inst. , Niigata Univ. , Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 248-248, 2006.

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P3K-37 Effect of berberine on Alzheimer's amyloid Aβ peptide production in neuroglioma H4 cells

Masashi Asai1, 2, Nobuhisa Iwata2, Takaomi C. Saido2, Kei Maruyama1
1Dept. Pharmacol. , Saitama Med. Sch. , Saitama, Japan,, 2Lab. for Proteolytic Neuroscience, RIKEN Brain Sci. Insti. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 248-248, 2006.

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P3K-38 Association of TRPM2 channel with a novel EF-hand protein, EFHC1

Masahiro Katano
Laboratory of Molecular Biology, Dept. Synthetic Chemistry and Biological Chemistry, Sch. Engineering, Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 248-248, 2006.

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P3K-39 Centrally mediated analgesic effects of the anticonvulsant zonisamide in inflammatory pain and painful diabetic neuropathy

Takuhiro Murakami, Mitsuo Tanabe, Motoko Honda, Hideki Ono
Lab. CNS Pharmacol. , Grad. Sch. Pharm. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 249-249, 2006.

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P3K-40 Pharmacological characterization of 7-hydroxymitragynine, an alkaloid from Thai medicinal plant Mitragyna speciosa, antinociception, tolerance and cross-toler-ance to morphine in mice: Involvement of μ-opioid receptors

Kenjiro Matsumoto1, Hiromitsu Takayama2, Kimihito Tashima1, Syunji Horie1
1Lab. Pharmacol. , Fac. Pharm. Sci. , Josai Int. Univ. , Chiba, Japan,, 2Lab. Mol. Struc. Biol. Func. , Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 249-249, 2006.

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P3K-41 Spinal cord injury enhances the 5-HT-induced inhibition of spinal monosynaptic reflex in rats

Motoko Honda, Emiko Shigetoshi, Mitsuo Tanabe, Hideki Ono
Lab. CNS Pharmacol. , Grad. Sch. Pharm. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 249-249, 2006.

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P3K-42 Study of neuropathic pain mechanisms II: Phosphorylated ERK in various seg-ments of spinal cord following somatic and visceral pain

Asuka Yamaguchi, Makoto Inoue, Hiroshi Ueda
Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 249-249, 2006.

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P3K-43 The relation of κ-receptors to hyperalgesia in SART (repeated cold)-stressed mice

Eiji Itoh, Yoshinori Funakami, Yasunori Okashima, Taeko Hata
Dept. Pharmacol. , Fac. Pharmaceut. Sci, Kinki Univ. , Higashi-Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 250-250, 2006.

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P3K-44 Effects of fluvoxamine on allody-nia- and anxiety-like behavior induced by sciatic nerve ligation in mice

Toshiko Shimoi, Akiyoshi Saitoh, Chihiro Nozaki, Noritaka Hirose, Junzo Kamei
Dept. of Pathophysiol. and Therap. , Sch. of Pharm. and Pharm. Sci. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 250-250, 2006.

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P3K-45 Contribution of capsaicin-sensitive fibers on spinal ventral root after-dis-charges evoked by nociceptive mechanical stimuli

Syohei Yamamoto, Motoko Honda, Mitsuo Tanabe, Hideki Ono
Lab. CNS Pharmacol. , Grad. Sch. Pharm. Sci, Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 250-250, 2006.

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P3K-46 Opioid effects of indole alkaloids related to Thai narcotic herb Mitragyna spe-ciosa

Yoshio Hatori1, Syunji Horie2, Kenjiro Matsumoto2, Kaori Misawa3, Mariko Kitajima3, Hiromitsu Takayama3, Toshihiko Murayama1
1Dept. Chem. Pharmacol. , Grad. Sch. Pharm. Sci. , Chiba Univ. , Chiba, Japan,, 2Dept. Pharmacol. , Fac. Pharm. Sci. , Josai International Univ. , Chiba, Japan,, 3Dept. Mol. Struct. and Biol. Functon, Grad. Sch. Pharma. Sci. , Chiba Univ, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 250-250, 2006.

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P3K-47 Gastrointestinal transit inhibition by oxycodone and fentanyl is mediated by μ-opioid receptor

Harumi Hata, Hideaki Kobayashi, Hiroshi Komatsu, Ichiro Sora
Dept. Psychobiol. , Tohoku Univ. Grad. Sch. Med. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 251-251, 2006.

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P3K-48 Characterization of micturition-related single neuron activities and their dis-tribution in periaqueductal gray matter (PAG) in anesthetized rats

Kengo Matsumoto, Tetsuya Shirasaki, Gen Yamamoto, Fumio Soeda, Kazuo Takahama
Dept. Environ. & Molec. Health Sci. , Grad. Sch. Pharm. Sci, Kumamoto Univ. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 251-251, 2006.

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P3K-49 Modification by clorgyline, a monoamine oxidase-A inhibitor, of morphine-induced hyperlocomotion and antinocicep-tion in mice

Nobue Kitanaka1, Junichi Kitanaka1, Tomohiro Tatsuta1, 2, Yoshio Morita2, Motohiko Takemura1
1Dept. Pharmacol. , Hyogo Col. Med. , Nishinomiya, Japan,, 2Dept. Neuropsychiat. , Hyogo Col. Med. , Nishinomiya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 251-251, 2006.

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P3K-50 The intracerebroventricular administration of D-serine potentiates antinociceptive effect

Kenji Ito1, Masanobu Yoshikawa2, Kazuhito Akahori2, Xing Lu Jin2, Hasuhiro Niino2, Atsushi Hashimoto2, Hiroyuki Kobayashi2, Toshiyasu Suzuki1, Tetsuo Oka2
1Dept. Anesthesiol. , Tokai Univ. Sch. Med. , Kanagawa, Japan,, 2Dept. Pharmacol. , Tokai Univ. Sch. Med. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 251-251, 2006.

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P3K-51 The intracerebroventricular administration of D-serine potentiates the antinociceptive effect of morphine on tail flick response in rats

Tomomi Kobayashi1, Masanobu Yoshikawa1, Kenji Ito2, Xing Lu Jin1, Kenya Kosaka1, Atsushi Hashimoto1, Hiroyuki Kobayashi1, Toshiyasu Suzuki2, Tetsuo Oka1
1Dept. Pharmacol. , Tokai. Univ. Sch. Med. , Kanagawa, Japan,, 2Dept. Anesthesiol. , Tokai Univ. Sch. Med, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 252-252, 2006.

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P3K-52 Analgesic action of intrathecal nicotine on the tibial nerve transection (TNT)-induced mechanical allodynia in rats

Norimitsu Morioka1, Joynal Abdin1, Tomoya Kitayama1, Katsuya Morita1, Shigeo Kitayama2, Toshikatsu Nakajima3, Toshihiro Dohi1
1Dept. Dental Pharmacol. , Hiroshima Univ. Grad. Sch. Biomed. Sci. , Hiroshima, Japan,, 2Dept. Dental Pharmacol. , Okayama Univ. Grad. Sch. Med. , Dent. and Pharmaceut. Sci. , Okayama, Japan,, 3Dept. Physical Ther. , Kio Univ. , Nara, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 252-252, 2006.

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P3K-53 Antinociceptive effect of McN-A-343 on noxious stimulation and mechanical allodynia

Kenji Honda, Keigo Horikawa, Suguru Kubo, Rintaro Takeuchi, Ryo Saito, Yukio Takano
Dept. Physiol. and Pharmacol. , Fac. Pharm. Sci. , Fukuoka Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 252-252, 2006.

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P3K-54 Differential effects of N-peptidyl-0-acyl hydroxylamines on dynorphin-induced antinociception in the mouse capsaicin test

Koichi Tan-no1, Aki Taira1, Osamu Nakagawasai1, Fukie Niijima1, Hans-Ulrich Demuth2, Jerzy Silberring3, Lars Terenius4, Takeshi Tadano1
1Dept. Pharmacol. , Tohoku Pharmaceu. Univ. , Sendai, Japan,, 2Probiodrug AG, Biocenter, Halle (Saale) Germany,, 3Jagiellonian Univ. , Krakow , Poland,, 4Karolinska Inst. , Stockholm , Sweden
Journal of Pharmacological Sciences 100 (suppl.2) 252-252, 2006.

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P3K-55 Cellular distribution of peripheral benzodiazepine receptor in the brain injury produced by ethanol injection

Jun Maeda, Makoto Higuchi, Motoki Inaji, Eisuke Haneda, Bin Ji, Takashi Okauchi, Tetsuya Suhara
Mol. Imaging Center, Natl. Inst. Radiological Sci. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 253-253, 2006.

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P3K-56 Relationships between individual differences in morphine analgesia and P-gly-coprotein activity of brain capillary endothelial cells in mice

Wakako Hamabe, Takehiko Maeda, Yohji Fukazawa, Kazumasa Kumamoto, Akihiro Yamamoto, Lu Qing Shang, Chizuko Yamamoto, Hiroaki Gyobu, Shiroh Kishioka
Dept. Pharmacol. , Wakayama Med. Univ. , Wakayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 253-253, 2006.

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P3K-57 Formalin-induced nociception alters expression of cation chloride cotransporters in the rat spinal cord

Hidehiko Nomura1, 2, Atsushi Sakai2, Masatoshi Nagano2, Masahiro Umino1, Hidenori Suzuki2
1Sect. Anesthesiol. and Clinical Physiol. , Tokyo Med. and Dent. Univ. , Tokyo, Japan,, 2Dept. Pharmacol. , Nippon Med. Sch. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 253-253, 2006.

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P3K-58 Influences of hypothermia on anesthetic effect and pharmacodynamics of propofol in cardiopulmonary bypass patients and rats

Yoshiro Okano1, Shiro Ishida1, Masayuki Ejiri1, Michihisa Kato2, Kazunori Yamakawa3
1Dept. Pharmac. Care & Clin. Pharm. , Fac. Pharmac. Sci. , Tokushima Bunri Univ. , Tokushima, Japan,, 2Divi. Anethesiol. , Tokushima Red-Cross Hosp. , Komatsushima, Japan,, 3Divi. Pharm. , Tokushima Red-Cross Hosp. , Komatsushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 253-253, 2006.

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P3K-59 (-)-Pentazocine thermal and mechanical antinociception are eliminated and chemical antinociception reduced in μ-opioid receptor knockout mice

Soichiro Ide1, 2, Masabumi Minami3, George R Uhl4, Kumatoshi Ishihara1, Ichiro Sora5, Kazutaka Ikeda2
1Lab. Neuropharmacol. , Dept. Pharmaceutical Sci. , Hiroshima Int. Univ. , Kure, Japan,, 2Mol. Psychiat. Res. , Tokyo Inst. Psychiat. , Tokyo, Japan,, 3Dept. Pharmacol. , Hokkaido Univ. Grad. Sch. Pharmaceutical Sci. , Sapporo, Japan,, 4MNB, NIDA/IRP, Baltimore , USA,, 5Divi. Psychobiol. , Dept. Neurosci. , Tohoku Univ. Grad. Sch. Med. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 254-254, 2006.

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P3K-60 α2-adrenergic and 5-HT2A receptors mediate the antiallodynic effect of fluox-etine in neuropathic pain mice

Miyuki Shiozawa, Motoko Honda, Mitsuo Tanabe, Hideki Ono
Grad. Sch. Pharm. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 254-254, 2006.

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P3K-61 Blockade of glycine transporter type 1 reduces neuropathic and inflammatory pain

Sachiko Yamaguchi, Keiko Takasu, Motoko Honda, Hideki Ono, Mitsuo Tanabe
Lab. CNS Pharmacol. , Grad. Sch. Pharm. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 254-254, 2006.

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P3K-62 Antinociceptive effect of prostaglandins in neuropathic pain model rats

Yutaka Tamura1, Kyoko Kusu1, Mayuko Monden1, Mitsuteru Shintani2, Hirohito Shiomi1
1Dept. of Pharmacol. , Fukuyama Univ. , HIroshima, Japan,, 2Res. Center for Green Sci. , Fukuyama, Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 254-254, 2006.

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P3K-63 Involvement of brain PKC in nitrous oxide (N2O)-incduced antinociception in mice

Yosuke Matsushita1, Kenji Abe2, Masago Ishikawa1, Iku Utsunomiya1, Keiko Hoshi1, Raymond. M. Quock3, Kyoji Taguchi1
1Dept. Pharmacothera. , Shoyaku Univ. , Tokyo, Japan,, 2Dept. Pharmacol. , Ohu. Univ. , Fukusima Japan,, 3Dept. Pharmaceu. Sci. , Washington State Univ. , Pullman, USA
Journal of Pharmacological Sciences 100 (suppl.2) 255-255, 2006.

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P3K-64 Gabapentin supraspinally accelerates spinal noradrenaline turnover in a murine neuropathic pain model

Yuichi Takeuchi, Mitsuo Tanabe, Motoko Honda, Hideki Ono
Lab. CNS Pharmacol. , Grad. Sch. Pharm. Sci. , Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 255-255, 2006.

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P3K-65 Gabapentin reduces GABAergic synaptic transmission in locus coeruleus neurons following partial nerve injury in mice

Keiko Takasu, Motoko Honda, Hideki Ono, Mitsuo Tanabe
Lab. CNS Pharmacol. , Grad. Sch. Pharm. Sci, Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 255-255, 2006.

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P3K-66 Mechanism of pain-related behavior evoked by intrathecal morphine-3-glu-clonide

Takaaki Komatsu1, Maki Shigeno1, MIka Sasaki1, Chikai Sakurada2, Minoru Tsuzuki1, Shinobu Sakurada3, Tsukasa Sakurada1
1Dept. Biochem. , Daiichi Coll. Pharmaceau. Sci. , Fukaoka, Japan,, 2Dept. Biochem. , Nihon Pharmaceu. Univ. , Saitama, Japan,, 3Dept. Physyol. Anat, Tohoku Pharmaceu. Univ. , Sendai, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 255-255, 2006.

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P3K-67 BMP signaling induces transdiffer-entiation of microglia into functional neurons

Satoru Matsuda, Tetsuhiro Niidome, Yasuaki Goto, Masaya Nakanishi, Takeshi Kihara, Hachiro Sugimoto
Dept, of. Neurosci. Drug Discov. , Grad. Sch. Pharmaceutical Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 256-256, 2006.

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P3K-68 Induction of DNA double-strand breaks and repair proteins before neural pro-genitor cell differentiation

Masahiro Kawabata1, Tetsuya Ogino2, Teruyuki Kawabata3
1Dept. Neurosci. , Grad. Sch. Med. Dent. Pharm. , Okayama Univ. , Okayama, Japan,, 2Dept. Path. Res. , Grad. Sch. Med. Dent. Pharm. , Okayama Univ. , Okayama, Japan,, 3Dept. Med. Engi. , Facul. Sci. , Okayama Univ. Sci. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 256-256, 2006.

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P3K-69 Hyperexcitability arrests newly-born cells in the dentate hilus ex vivo

Ryuta Koyama, Makoto Tamura, Maki Yamada, Norio Matsuki, Yuji Ikegaya
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 256-256, 2006.

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P3K-70 Neuronal differentiation of ES cells grown on Matrigel, reconstituted base-ment membranes

Takeshi Shimada1, Hitoshi Hashimoto1, Megumi Hirose1, 2, Norihito Shintani1, Akemichi Baba1
1Lab. Mol. Neuropharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 2JSPS Research Fellow, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 256-256, 2006.

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P3K-71 Effect of N-acetyl-L-cysteine on proliferation in neural progenitor cells of the hippocampus

Masanori Yoneyama, Kiyokazu Ogita
Dept. Pharmacol. , Faculty of Pharma. Sci. , Setsunan Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 257-257, 2006.

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P3K-72 Possible enhancement of neuro-genesis after neuronal injury in olfactory system of mice

Koichi Kawada, Shogo Azuma, Masanori Yoneyama, Kiyokazu Ogita
Dept. Pharmacol. , Setsunan Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 257-257, 2006.

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P3K-73 Effects of α1 -adrenergic receptor agonist on the proliferation of embryonic neural progenitor cells in vitro

Takeshi Hiramoto, Yasunari Kanda, Yoshiaki Ihara, Takashi Hinata, Yasuhiro Watanabe
Dept. Pharmacol. , Natl. Def. Med. Coll. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 257-257, 2006.

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P3K-74 Cerebral salt wasting after sub-arachnoid hemorrhage is directly proportional to the bleeding amount

Jun Kojima1, 2, Yoichi Katayama1, Maki Yoneko2, Takahiro Igarashi1, Tatsuro Mori1, Hiroyuki Kawai2, Aiko Usui2, Kouichi Itoh2, Nobuhiro Moro1
1Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan,, 2Pharmaceutical Research Laboratory, Nikken Chemicals Co. , Ltd. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 257-257, 2006.

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P3K-75 Mechanism of delayed neuronal death produced in SHRSP by transient fore-brain ischemia

Yasuko Sakurai-Yamashita1, 2, Toru Nabika2, Masami Niwa1
1Dept Pharmacol. 1, Nagasaki Univ. Grad. Sch. of Biom. Sci. , Nagasaki, Japan,, 2Dept Funct Pathol, Sch. of Med. , Shimane Univ. , Izumo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 258-258, 2006.

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P3K-76 SUN N8075, a novel neuroprotective agent, shows long-term neuroprotection in rats subjected to transient focal cerebral Ischemia

Shinya Ueno, Tomokazu Shimonaga, Shigeki Tamura, Shizuo Nakamura, Tomochika Ohno
Biomedical Research Laboratories, Daiichi Asubio Pharma Co. , Ltd. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 258-258, 2006.

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P3K-77 SUN N8075, a neuroprotective agent, state-dependently blocks Na+ and T-type Ca2+ channels and Inhibits glutamate release during cerebral Ischemia in rats

Shigeki Tamura, Yoshihiro Tani, Shinya Ueno, Yukiko Hagino, Shizuo Nakamura, Tomochika Ohno
Biomedical Research Laboratories, Daiichi Asubio Pharma Co. , Ltd. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 258-258, 2006.

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P3K-78 FK506 reduces hemorrhagic transformation produced by delayed t-PA treatment in the thrombotic focal cerebral ischemia in spontaneously hypertensive rats

Yasuhisa Furuichi, Masashi Maeda, Takahisa Noto, Nobuya Matsuoka, Seitaro Mutoh
Pharmacology Research Labs. , Astellas Pharma Inc. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 258-258, 2006.

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P3K-80 Protective effect of serofendic acid on ischemic damage induced by a middle cerebral artery occlusion in rats

Tomohiro Nakamura1, Toshiaki Kume1, Hiroshi Katsuki1, Hachiro Sugimoto2, Akinori Akaike1
1Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan,, 2Dept. Neurosci. Drug. Discov. , Grad. Sch. Pharm. Sci. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 259-259, 2006.

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P3K-81 Prostaglandin E2 produced by microsomal prostaglandin E synthase-1 exacerbates ischemic brain injury

Azusa Ota1, Satoshi Uematsu2, Shizuo Akira2, Yuri Ikeda-Matsuo1
1Lab. Pharmacol. , Sch. Pharmac. Sci. , Kitasato Univ. , Tokyo, Japan,, 2Dept. Host Defense, Research Inst. Microbial Diseases, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 259-259, 2006.

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P3K-82 Moduration of cell cycle reduces neuronal cell death observed after ischemia-reperfusion in the rat retina

Kayo Ohki, Maki Saito, Tsutomu Nakahara, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol. , Kitasato Univ. Scj. Pharm. Sci. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 259-259, 2006.

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P3K-83 A behavioral method, circling behavior, for evaluating brain injury induced by hypoxia-ischemia in neonatal rats

Kazuhiko Harada, Kenichi Mishima, Naoya Aoo, Ryu Onitsuka, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara
Dept. Neuropharmacol. Faculty of Pharmaceutical Science, Fukuoka University, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 260-260, 2006.

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P3K-84 Analysis of genes whose expression is altered by brain temperature in rat forebrain ischemia model

Megumi Kobayashi1, Yayoi Nishida2, Yasuo Takahashi2, Toshihito Nagata2, Satoshi Asai2, Koichi Ishikawa1
1Dept. Pharmacol. , Nihon Univ. Sch. Med. , Tokyo, Japan,, 2Div. Genomic Epidemiology & ClinicalTrials. , Nihon Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 260-260, 2006.

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P3K-85 Screening for control genes in mouse hippocampus after transient forebrain ischemia using high-density oligonucleotide array

Yayoi Nishida1, Megumi Kobayashi2, Yasuo Takahashi1, Toshihito Nagata1, Koichi Ishikawa2, Satoshi Asai1
1Div. Genomic Epidemiology and Clinical Trials, Nihon Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Pharmacol. Nihon Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 260-260, 2006.

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P3K-86 Differential neuroprotective effects of delta9-tetrahydrocannabinol but not cannabidiol results in tolerance to the neuroprotective effects in mice subjected to middle cerebral artery occlusion

Kazuhide Hayakawa, Kenichi Mishima, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara
Dept. Neuropharmacol. , Pharmaceutical Sci. , Fukuoka Univ, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 260-260, 2006.

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P3K-87 Prostaglandin E2 aggravates ischemic injury via EP4 in a murine model of cerebral thrombosis

Akimasa Ri1, Koh-ichi Yuhki1, Jun-ichi Kawabe1, Akiyoshi Hara1, Yayoi Hosoki1, Osamu Takahata2, Hiroshi Iwasaki2, Shuh Narumiya3, Fumitaka Ushikubi1
1Dept. Pharmacol. , Asahikawa Med. Coll. , Asahikawa, Japan,, 2Dept. Anesth. , Asahikawa Med. Coll. , Asahikawa, Japan,, 3Dept. Pharmacol. , Kyoto Univ. Fac. Med. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 261-261, 2006.

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P3K-88 Involvement of Na+/Ca2+ exchanger-1 (NCX1) in reperfusion injury induced by middle cerebral artery occlusion in mice

Hiroko Namimatsu1, 2, Satomi Kita1, Nobutaka Morimoto3, Kazuhide Hayakawa2, Kenichi Mishima2, Katsunori Iwasaki2, Michihiro Fujiwara2, Masamitsu Shimazawa3, Hideaki Hara3, Toshio Matsuda4, Akemichi Baba5, Issei Komuro6, Takeshi Katsuragi1, Takahiro Iwamoto1
1Dept. Pharmacol. , Sch. Med. Fukuoka Univ. , Fukuoka, Japan,, 2Dept. Neuropharmacol. , Pharmaceut. Sci. , Fukuoka, Japan,, 3Dept. Biofunct. Mol. , Gifu Pharmaceut. Univ. , Gifu, Japan,, 4Lab. Medicinal Pharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 5Lab. Mol. Neuropharmacol. , Grad. Sch. Pharmaceut. Sci. , Osaka Univ. , Osaka, Japan,, 6Dept. Cardiovasc. Sci. Med. , Chiba Univ. Grad. Sch. Med. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 261-261, 2006.

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P3K-89 Exogenous microglia protect against focal brain ischemia in rats

Daijiro Yanagisawa, Yoshihisa Kitamura, Takashi Taniguchi
Dept. Neurobiol. , 21st Century COE Program, Kyoto Pharm. Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 261-261, 2006.

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P3K-90 Increased endoplasmic reticulum stress in the hippocampus of apolipoprotein E-deficient mice after cerebral ischemia and reperfusion

Nobuhiro Osada1, Yasuhiro Kosuge1, 2, Kumiko Ishige1, Yoshihisa Ito1
1Dept. of Pharmacol. , Coll. of Pharm. , Nihon Univ. , Funabashi, Japan,, 2Dept. of Pharmacol. , Tokyo Dental Coll. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 261-261, 2006.

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P3K-91 The effect of HGF on tight junction proteins after cerebral ischemia

Ichiro Date1, Norio Takagi1, Keiko Takagi1, Hiroshi Funakoshi2, Kunio Matsumoto2, Toshikazu Nakamura2, Satoshi Takeo1
1Dept. Mol. Cell. Pharmacol. , Tokyo Univ pharm. Life Sci, Tokyo, Japan,, 2Div. Mol. Reg. Med. , Osaka Univ. Sch. Med. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 262-262, 2006.

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P3K-92 Effects of neuroprotective agents on focal ischemia-induced neuronal damage in mice

Shin-ichiro Kamiya1, Masami Kato1, Tohru Toyoshi1, Takao Ota1, Hideaki Hara2
1Nihon Bioresearch Inc. , Gifu, Japan,, 2Gifu Ph. University, Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 262-262, 2006.

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P3K-93 Investigation for the effects of neuroprotective agents, cyclopentenone prostaglandin analogues in rat stroke model

Kazuya Hokamura1, Masahide Maeda2, Kyoji Furuta2, Masaaki Suzuki2, Kazuo Umemura1
1Dept. Pharmacol. , Hamamatsu Univ. Sch. Med. , Shizuoka, Japan,, 2Regeneration and Advanced Medical Science Gifu University, Graduate School of Medicine, Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 262-262, 2006.

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P3L-01 The actions of azelnidipine, a novel dihydropyridine-derivative Ca antago-nist, on voltage-dependent Ba2+ currents in guinea-pig vascular smooth muscle

Hai-Lei Zhu, Noriyoshi Teramoto, Toshihisa Tomoda, Manami Aishima, Yushi Ito
Dept. Pharmacol. , Kyushu Univ. Graduate Sch. Medical Sciences, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 262-262, 2006.

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P3L-02 A smooth muscle relaxant extracted from Physarum polycephalum (2nd report)

Shinji Yoshiyama1, Kouji Nagata2, Akio Nakamura1, Masaru Tanokura2, Kazuhiro Kohama1
1Dept. Mol. Cell. Pharmacol. , Gunma Univ. Grad. Sch. Med. , Gunma, Japan,, 2Grad. Sch. of Agric. Life Sci. , Univ. of Tokyo, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 263-263, 2006.

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P3L-03 Arachidonic acid enhances the hydrolysis step of ATPase by way of confor-mation change of the smooth muscle myosin

Takeshi Katayama, Mizuki Hino, Shinji Yoshiyama, Hideyuki Tanaka, Akio Nakamura, Kazuhiro Kohama
Dept. Mol. and Cell. Pharmacol. , Gunma Univ. Grad. Sch. Med. , Gunma, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 263-263, 2006.

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P3L-04 Effect of PDGF and sodium butyrate on growth, morphology, and properties of cultured vascular smooth muscle cell line AC01

Tsuyoshi Okagaki1, Akio Nakamura2, Kazuhiro Kohama2, Kana Nagasaki1, Yuki Kawai1
1Fuc. Bioresource, Mie Univ. , Mie, Japan,, 2Dept. Pharmacol. Gunma Univ. Sch. Med. , Gunma, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 263-263, 2006.

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P3L-05 Physiological roles for β-adreno-ceptor (β-AdR) and its subtypes in rat tho-racic aorta

Mizuho Miyagawa, Yoshio Tanaka, Katsuo Koike
Dept. Chem. Pharmacol. , Toho Univ. Sch. Pharmaceu. Sci. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 263-263, 2006.

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P3L-06 Histamine-induced relaxation mediated by H2-receptor and its distribution in rat blood vessels

Hong-Lan Piao, Tatsuru Tsurumaki, Shingo Nagayi, Hiroshi Higuchi
Div. Pharmacol. , Grad. Sch. Med. Dent. Sci. , Niigata Univ. , Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 264-264, 2006.

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P3L-07 Blebbistatin blocks PDGF-induced migration of vascular smooth muscle cell through inhibiting the ATPase activity of smooth muscle myosin II

Honghui Wang1, Xiaoran Qin2, Tiejun Zhao2, Lihong Ye2, Hideyuki Tanaka1, Akio Nakamura1, Kazuhiro Kohama1
1Dept. Mol. Cell. Pharmacol. , Gunma Univ. Sch. Med. , Gunma, Japan,, 2Coll. of Life Sci. , Nankai Univ. , Tianjin, China
Journal of Pharmacological Sciences 100 (suppl.2) 264-264, 2006.

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P3L-08 Effects of the extract from Nandina domestica Thunberg on the tra-cheal smooth muscle of the guinea pig

Muneo Tsukiyama1, 2, Tatsuhiro Akaishi2, Masanori Katada1, Kazuho Abe2
1NOEVIR CO. , LTD. , Kobe, Japan,, 2Lab. Pharmacol. , Fac. Pharm. & Res. Inst. , Pharmaceut. Sci. , Musashino Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 264-264, 2006.

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P3L-09 Pharmacological studies on the respiratory tract (Rept. 277): Protein kinase C subtypes involved in acetylcholine-induced contraction of rat bronchial smooth muscle

Maki Yamamoto, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Dept. Pharmacol. , Hoshi Univ. Sch. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 264-264, 2006.

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P3L-10 TRPV1 -independent relaxant effects of capsaicin and resiniferatoxin on isolated ileum in guinea-pig

Seigo Fujimoto, Mayumi Mori
Dept. Cell. Mol. Pharmacol. , Nagoya City Univ. , Grad. Sch. Med. Sci. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 265-265, 2006.

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P3L-11 Effect of LTD4 on decreasing acetylcholine induced contractions by H2O2 and AA861, an inhibitor of 5-lipoxygenase in guinea-pig ileum

Yoshiko Ohnishi, Koh-ichi Tanaka, Tomoaki Sato, Takashige Nishikawa
Dept. Applied Pharmacol. , Kagoshima Univ. Grad. Sch. Med. & Dent. Sci. , Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 265-265, 2006.

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P3L-12 In vitro development of intestine-like tissue demonstrating rhythmic motility from embryonic mouse intestinal cells: Development of interstitial cells of Cajal

Yuko Ito, Kazuhiko Oishi
Dept. Pharmacol. , Meiji Pharmaceutical Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 265-265, 2006.

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P3L-13 Effects of distigmine on the motili-ties of guinea-pig detrusor and urethral smooth muscles

Sarasa Sekiya, Natsumi Ookawa, Tomoko Aoki, Rie Akiyama, Tomoko Ono, Mari Shibano, Takahiro Horinouchi, Yoshio Tanaka, Katsuo Koike
Dept. Chem. Pharmacol. , Toho Univ. Sch. Pharmaceu. Sci. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 265-265, 2006.

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P3L-14 Herb derived substances, lignans are protective against cell death via p38 MAPK by reactive oxygen species in C2C12 myoblast cells

Ayumu Yoshikawa, Yumiko Saito, Kei Maruyama
Dept. Pharmacol. , Saitama Med. Sch. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 266-266, 2006.

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P3L-15 Immunochemical studies on migration and actin remodeling in vascular smooth muscle cells following sphingo-sylphosphorylcholine stimulation

Hideyuki Tanaka1, Sheng Li2, Sean Thatcher3, Dawn Brown3, Akio Nakamura2, Gray Wright3, Kazuhiro Kohama2
2Dept. Researchsci. , Gunma Univ. Sch. Health Sci. , Gunma, Japan,, 2Dept. Mole and Cell, Pharmacol. , Gunma Univ. Ggadu, Sch. Med. , Gunma, Japan,, 3Dept. Physiol, The Joan Edwards Sch. Med. Marshall Univ. , Huntington, USA
Journal of Pharmacological Sciences 100 (suppl.2) 266-266, 2006.

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P3L-16 Characterization of recombinant full-length smooth-muscle myosin light chain kinase

Kazufumi Kawano1, Akio Nakamura1, Ying Gao2, Ryoki Ishikawa1, Shinji Yoshiyama1, Yuki Hanyuda1, Ayumi Takahashi1, Kazuhiro Kohama1
1Dept. Mol. Cell. Pharmacol. , Gunma Univ. Grad. Sch. Med. , Gunma, Japan,, 2Dept. Biochem. and Mol. biol. , Dalian Unv. , Dalian, P. R. CHINA
Journal of Pharmacological Sciences 100 (suppl.2) 266-266, 2006.

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P3L-17 Intracellular release and the sub-sequent extracellular release of ATP evoked by bradykinin from cultured smooth muscle cells

Takeshi Katsuragi1, Yumei Zhao1, Chiemi Sato1, Sadaharu Usune2, Keisuke Migita1
1Dept. Pharmacol. , Sch. Med. , Fukuoka Univ. , Fukuoka, Japan,, 2Res. Lab. Biodynam. , Sch. Med. , Fukuoka Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 266-266, 2006.

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P3L-18 Expression and Charaterization of Heavy mero-myosin (HMM) of Physarum polycepharum

Ying Zhang1, Hozumi Kawamichi1, 2, Akio Nakamura1, Koichi Samizo1, Mizuki Hino1, Laszlo Farkas3, Laszlo Nyitray3, Kazuhiro Kohama1
1Dept. Mol. Cell. Pharmacol. , Gunma Univ. Grad. Sch. Med. , Gunma, Japan,, 2Dept. Mol. Physiol. , Yamaguchi Univ. , Sch. Med. , Yamaguchi, Japan,, 3Dept. Biochem. Eotvos Univ. , Budapest
Journal of Pharmacological Sciences 100 (suppl.2) 267-267, 2006.

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P3L-19 The distributions of miRNA from the differentiated and de-differentiated vasucular smooth muscle cells

Akio Nakamura1, Tsuyoshi Okagaki2, Kazuhiro Kohama1
1Dept. Mol. and Cell. Pharmacol. , Gunma Univ. Grad. Sch. Med. , Gunma, Japan,, 2Fuc. Bioresource, Mie Univ. , Mie, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 267-267, 2006.

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P3L-20 Effect of manipulating serum phosphorus with sevelamer hydrochloride, a phosphate binder, on circulating parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23) levels in rats with chronic renal insufficiency

Nobuo Nagano1, 2, Sonoe Miyata2, Megumi Abe2, Nami Kobayashi2, Sachiko Wakita2, Michihito Wada2
1Medical Affairs Section, Kirin Brewery Co. , Ltd. , Tokyo, Japan,, 2Pharmaceutical Develop. Labs, Kirin Brewery Co. , Ltd. , Gunma, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 267-267, 2006.

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P3L-21 Inhibition by tranilast of nifedipine-induced proliferation of cultured human gingival fibroblasts

Toshimi Hattori, Pao-Li Wang
Dept. of Dent. Pharmacol. , Matsumoto Dent. Univ. , Shiojiri, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 267-267, 2006.

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P3L-22 Involvement of calcineurin in osteoclastogenesis mediated by RANKL

Tsutomu Iida1, Hiroshi Egusa1, Makio Saeki2, Yuki Itsuki1, Hirofumi Yatani1, Yoshinori Kamisaki2
1Dept. Fixed Prosthodontics, Grad. sch. Dent. Osaka Univ. , Suita, Japan,, 2Dept. Pharmacol, Grad. sch. Dent. Osaka Univ. , Suita, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 268-268, 2006.

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P3L-23 Effect of cytokine on ESE-3 expression in human oral epithelial cells

Hiroko Matsumoto1, Yoshiaki Akimoto2, Akira Fujii1
1Dept. Oral Mol. Pharmacol. , Nihon Univ. Sch. Dent. Chiba, Japan,, 2Dept. Oral Surg. , Nihon Univ. Sch. Dent. Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 268-268, 2006.

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P3L-24 PPARδ-regulated c-fos promoter activity contributes to RANKL-induced osteoclastogenesis

Yoshie Kawagishi, Toshio Kaneda, Youhei Machida, Yuuki Fujii, Sayuri Hayakawa, Takuya Higaki, Akihiro Mutou, Tadashi Yoshida
Dept. of Pathophysiology, Faculty of Pharmaceutical Sci. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 268-268, 2006.

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P3L-25 Berberine inhibits RANKL-, TNFα-, LPS- and PGN-induced mature osteoclasts survival

Jin-Ping Hu, Kazuhisa Nishishita, Eiko Sakai, Kuniaki Okamoto, Yuzo Kato
Dept. Develop. Reconstruct. , Grad. Sch. Biomed. Sci, Nagasaki Univ, Nagasaki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 268-268, 2006.

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P3L-26 TNF receptor Type1 has a pivotal role for local bone resorption induced by LPS in vivo

Hussain Anower, Hiroaki Saito, Kazuhiro Aoki, Keiichi Ohya
Sect. Pharmacol. , Dept. Hard tissue engineering, Tokyo Med. & Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 269-269, 2006.

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P3L-27 Molecular cloning and expression of a truncated isoform of CLCA in rat sub-mandibular gland

Jun Yamazaki, Kenji Kitamura
Dept. Physiol. Sci. & Mol. Biol. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 269-269, 2006.

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P3L-28 nrf2 expressed by bone and carti-lage

Eiichi Hinoi, Liyang Wang, Sayumi Fujimori, Yukio Yoneda
Dept. Mol. Pharmacol. , Kanazawa Univ. , Grad. Sch. Nat. Sci. and Tech. , Ishikawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 269-269, 2006.

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P3L-29 Effects of alendronate alone and in combination with MK-4 on bone mineral density in phenytoin induced osteopenia in growing rats

Kenji Onodera1, Atsushi Takahashi2, Junzo Kamei3
1Dept. Dental Pharmacol. , Okayama Univ. Sch Med and Dent. , Okayama, Japan,, 2Dentistry for the Disabled, Tohoku Univ Dental Hosp. , Sendai, Japan. ,, 3Dept. Pathophysiology & Therapeutics, Faculty of Pharmaceutical Sci. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 269-269, 2006.

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P3L-30 Improvement of the bone quality by trehalose in ovariectomized mice

Kahoru Taya, Shiho Matsubuchi, Shoei Sugashima, Setsuo Hamada
Dental Pharmacology, Dept. of Oral Medical Science, Ohu Univ. Sch. of Dentistry, Fukushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 270-270, 2006.

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P3L-31 Phenolic compounds enriched in the traditional antidiarrheic inhibit ovariecto-my-induced bone loss

Nobuaki Moriguchi1, 2, Eiichi Hinoi1, Yukio Yoneda1
1Dept. Mol. Pharmacol. , Kanazawa Univ. , Grad. Sch. Nat. Sci. and Tech. , Ishikawa, Japan,, 2Taiko Pharmaceutical Co. , Ltd, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 270-270, 2006.

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P3L-32 Effect of Boiogito on a rat osteoarthritis model

Mitsuo Tamai, Naoki Fujitsuka, Tomohisa Hattori, Yoshio Kase, Shuichi Takeda, Hiroshi Sasaki
Pharmacol. Res. Dept. , Central Lab. , Tsumura & CO. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 270-270, 2006.

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P3L-33 The synergistic effect of atorvas-tatin and raloxifene on bone density in ovariectomized rats

Shiho Matsubuchi, Kahoru Taya, Shoei Sugashima, Setsuo Hamada
Dental Pharmacology, Dept. of Oral Medical Science, Ohu Univ. Sch. of Dentistry, Fukusima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 270-270, 2006.

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P3L-34 Contribution of TGF-α to EGF receptor transactivation leading to proliferative response of rabbit gingival fibroblasts to angiotensin II and endothelin-1

Nozomi Ohuchi1, Yumiko Taniguchi2, Kazuhiko Hayashi3, Yasuo Kizawa4, Katuso Koike5, Masami Ohsawa6, Keishi Iwamoto5, Michiyoshi Nukaga1, Tomohito Kakegawa1, Hajime Murakami5
1Josai International Univ. , Chiba, Japan,, 2Kinjyo Gakuin Univ. , Nagoya, Japan,, 3Nihon Univ. Sch. of Dent. at Chiba, Japan,, 4Nihon Univ. Coll. of Pharmacy, Chiba, Japan,, 5Toho Univ. Sch. Pharmaceut. Sci. , Chiba, Japan,, 6Nihon Univ. Coll. of Ind. Tech. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 271-271, 2006.

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P3L-35 Erk-1/2 signaling regulates cleft formation in submandibular gland branching morphogenesis

Noriko Koyama1, Gresik Edward2, Masanori Kashimata1
1Dept. Pharmacol. , Asahi Univ. Sch. Dent. , Gifu, Japan,, 2Dept. Cell Biol. and Anat. Sci. , CUNY. Med. Sch. , 138th Street & convent Ave. New York, USA
Journal of Pharmacological Sciences 100 (suppl.2) 271-271, 2006.

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P3L-36 Glutamatergic signaling machiner-ies expressed by mesenchymal stem cells line C3H10T1/2 cells

Mika Iemata, Sayumi Fujimori, Eiichi Hinoi, Yukio Yoneda
Lab. Mol. Pharmacol. , Kanazawa Univ. Grad. Sch. Nat. Sci. Tech. , Kanazawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 271-271, 2006.

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P3L-37 The effectiveness on gene expression profiling of cytokines in collagen-induced arthritis (CIA) model rats

Makoto Hiroyasu, Tadahiro Fukuhara, Seiichi Katayama, Susumu Kyoku, Kentarou Andou
Pharmacology Division, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 271-271, 2006.

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P3M-O1 Differences in coupling interval-dependent effects of sotalol on infarcted and noninfarcted areas of dog hearts after myocardial infarction

Hisakuni Hashimoto1, Tomohiro Ohmura1, Tomohiro Yamamoto1, Ryuta Nakamura1, Shinji Watanabe1, Kazuo Umemura2
1Dept. Hospital Pharmacy, Hamamatsu Univ. Sch. Med. , Hamamatsu,, 2Dept. Pharmacol. , Hamamatsu Univ. Sch. Med, , Hamamatsu
Journal of Pharmacological Sciences 100 (suppl.2) 272-272, 2006.

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P3M-02 Protective effect of rosiglitazone on rat myocardial reperfusion injury: Difference according to administering method

Masahiro Abe1, Satoshi Ichimaru1, Koichiro Tsuchiya1, Koichiro Wada2, Yoshiharu Takiguchi1
1Dept. Clin. Pharmacol. , Tokushima Univ. Inst. Health Biosci. , Tokushima, Japan,, 2Dept. Pharmacol. , Grad. Sch. Dent. , Osaka Univ. , Suita, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 272-272, 2006.

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P3M-03 KP-102 (GHRP-2) attenuates ischemia/reperfusion injury in the isolated rat hearts

Sadayoshi Furuta, Toshimitsu Hori, Tadashi Ohyama
Pharmacol. Dept. , Central Res. Lab. , Kaken Pharm. Co. Ltd. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 272-272, 2006.

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P3M-04 Effect of aging on ischemia-reperfusion injury in isolated rat hearts

Saori Suzuki, Yukiko Kuwata, Ichiro Hirotsu
Pharmaceutical Research Center, Nipro Corp. , Kusatsu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 272-272, 2006.

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P3M-05 Protective effects of EGCg against postischemic myocardial dysfunction in guinea pig hearts

Masaya Hirai1, Huang Lei2, Yoshihiro Hotta2, Naohisa Ishikawa2, Hiromi Tsushima3, Hiroaki Ando3
1Dept. Cardiac Surgery. , Aichi Med. Univ. Sch. Med. , Aichi, Japan,, 2Dept. Pharmacol. , Aichi Med. Univ. Sch. Med. , Aichi, Japan,, 3Coll. Pharm. , Kinjo Gakuin Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 273-273, 2006.

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P3M-O6 Effects of short-term Ginkgo bilo-ba extract feeding on hypotensive action of nicardipine in rat

Yoko Kubota1, Keizo Umegaki2, Satomi Kagota1, Namie Nejime1, Kazuki Nakamura1, Masaru Kunitomo1, Kazumasa Shinozuka1
1Dept. Pharmacol. Sch. Pharmaceu. Sci. , Mukogawa Women's Univ. , Nishinomiya, Japan,, 2Natl. Inst. Health Nutrition, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 273-273, 2006.

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P3M-07 Examination of a method for making the repetitive evaluation of respiratory functions in a cardiovascular study using monkeys

Yoshiki Tate, Yasuki Akie, Masaru Sugiyama, Yoshinori Ishiyama, Kiyotaka Hoshiai, Tadashi Kakoi, Akiharu Fujino
Fuji biomedix CO. , LTD. Kobuchisawa Lavoratories, Yamanashi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 273-273, 2006.

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P3M-08 Evaluation of drug-induced ortho-static Hypotension (OH) in a conscious dog using telemetry system

Kennosuke Akiyama1, Norio Odagiri1, Syuhei Katou1, Naoki Inamura2, Kentaro Ando1
1Pharmacology Division, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, Japan,, 2Toxicology Laboratory, Mitsubishi Pharma Corporation, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 273-273, 2006.

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P3M-09 Influence of ω-3 fatty acid on platelet-leukocyte complex formation in patients undergoing cardiac surgery

Hiroko Kariyazono1, Kazuo Nakamura1, Ryuji Ikeda1, Junko Arima1, Keitaro Obana1, Hiroyuki Yamamoto2, Ryuzo Sakata2, Katsushi Yamada1
1Dept. Clin. Pharm. Pharmacol. , Grad. Sch. Med. Dent. Sci. , Kagoshima Univ. , Kagoshima, Japan,, 2Dept. Thorac. Cardiovasc. Surg. , Grad. Sch. Med. Dent. Sci. , Kagoshima Univ. , Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 274-274, 2006.

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P3M-10 Accumulated endogenous NOS inhibitors and accelerated arginase activity in impaired NO production in pulmonary hypertensive rats

Akihito Sasaki1, Shouzaburoh Doi1, Hiroko Wakimoto1, Shuki Mizutani1, Hiroshi Azuma2
1Dept. Pediatrics and Developmental Biology, Graduate Sch of Med, Tokyo Medical and Dental Univ. , Tokyo, Japan,, 2Dept. Biosystem Regulation, Inst. Biomaterials and Bioengineering, Tokyo Medical and Dental Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 274-274, 2006.

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P3M-11 Bloodborne factor from rat with common bile duct ligation causes blunted hypoxic pulmonary vasoconstriction via NO and Kca channel

Masatoshi Imamura1, 2, Yuki Imamura2, Ethan Carter2, Chrystelle Garat-Carter2, Hiroshi Azuma1
1Department of Biosystem Regulation, Institute of Biomaterials & Bioengineering, Tokyo Medical & Dental University, Tokyo, Japan,, 2Cardiovasclar-Pulmonary Research Lab. , Univ. of Colorado at Denver and Health Sciences Center, Denver, USA
Journal of Pharmacological Sciences 100 (suppl.2) 274-274, 2006.

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P3M-12 Angiontensin II leads to impairment of SERCA-dependent relaxation and enhancement of nitrotyrosine in diabetic rat aorta

Takagoro Nogami, Tsuneo Kobayashi, Takayuki Matsumoto, Katsuo Kamata
Dept. Physiol. and Morphol. , Inst. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 274-274, 2006.

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P3M-13 Inhibitory effect of lomerizine on TRP channel-mediated calcium influx

Masakazu Ishii1, Shunichi Shimizu1, Yasuo Mori2, Yuji Kiuchi1
Dept. Pathophysiol. , Sch. Pharm. Sci. , Showa Univ. , Tokyo, Japan,, 2Lab. Mol. Biol. , Sch. Engineer. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 275-275, 2006.

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P3M-14 The effects of antithrombotic drugs on coagulation time and thrombus formation in an AV-shunt model

Katsuhiko Hori, Noriko Minobe, Daisuke Saji, Takashi Shimosato, Ayahito Kimura, Isami Kimura
Research Dep. , Shiga Lab. , NISSEI BILLS Co. , Ltd. , Shiga, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 275-275, 2006.

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P3M-15 Anti-atherosclerotic effect of Pioglitazone in metabolic syndrome model rat

Ryo Saiki1, Masako Okazaki1, Shinichi Iwai1, Hiroshi Gomibuchi1, Toshio Kumai2, Shinichi Kobayashi2, Katsuji Oguchi1
1Dept. Pharmacol. , Showa Univ. Sch. Med. , Tokyo, Japan,, 2Dept. Pharmacol. , St. Marianna Univ. Sch. Med, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 275-275, 2006.

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P3M-16 Hyperfibrinogenemia in sponta-neously hypertensive and hyperlipidemic rats is independent from IL6 pathway

Hiroshi Gomibuchi1, Masako Okazaki1, Shinichi Iwai1, Ryo Saiki1, Toshio Kumai2, Shinichi Kobayashi2, Katuji Oguchi1
1Dept. Pharmacol. , Showa Univ. Sch. Med, Tokyo,, 2Dept. Pharmacol. St. Marianna Univ. Sch. Med. , Kanagawa
Journal of Pharmacological Sciences 100 (suppl.2) 275-275, 2006.

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P3M-17 Pioglitazone improves matrix met-alloproteinase-9 activity in plasma in a metabolic syndrome model rat

Koichi Suda1, Shinichi Iwai1, Masako Okazaki1, Masaya Yamaguchi1, Yasuhiko Asano1, Akihiko Yura1, Toshio Kumai2, Shinichi Kobayashi2, Katsuji Oguchi1
1Dept. Pharmacol. , Showa Univ. , Sch. Med. , Tokyo, Japan,, 2Dept. Pharmacol. , St. Marianna Univ. , Sch. Med. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 276-276, 2006.

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P3M-18 Effect of angiotensin AT1 receptor antagonist on the vascular expression of eNOS and phosphorylated eNOS in sponta-neously hypertensive rats

Fumiaki Kimura, Katsutoshi Yayama, Hiroshi Okamoto
Dept. Pharmacol. , Kobe Gakuin Univ. Sch. Pharmaceutical Sciences. , Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 276-276, 2006.

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P3M-19 Expression of Rho kinase and MYPT1 is increased in carotid arteries from spontaneously hypertensive rats (SHR)

Masahisa Asano1, Tomiko Asano2
1Dept. Cell. Mol. Pharmacol. , Grad. Sch. Med. Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Inst. for Dev. Res. , Aichi Human Service Ctr. , Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 276-276, 2006.

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P3M-20 Rho kinase-mediated phosphory-lation at Thr-850 of MYPT1 in the resting state of carotid arteries from spontaneously hypertensive rats (SHR)

Masahisa Asano1, Tomiko Asano2
Dept. Cell. Mol. Pharmacol. , Grad. Sch. Med. Sci. , Nagoya City Univ. , Nagoya, Japan,, 2Inst. for Dev. Res. , Aichi Human Service Ctr. , Aichi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 276-276, 2006.

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P3M-21 Pharmacokinetic characterization of celiprolol-grapefruit juice interaction in rats

Yoshihiro Uesawa, Kiminori Mohri
Dept. Clin. Pharm. , Meiji Pharmaceut. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 277-277, 2006.

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P3M-22 Higher sympathetic activity in standing related to lower parasympathetic activity in supine position

Makie Higuchi, Naoko Kouduma, Hiroaki Furukata, Keiko Maetaka
Div. Pharmacol. , Kyushu Univ. of Nurs. & S. W, Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 277-277, 2006.

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P3M-23 Plasmin-induced endothelium-dependent relaxation in coronary artery

Tetsuhiro Fujiyoshi, Katsuya Hirano, Mayumi Hirano, Naohisa Niiro, Hideo Kanaide
Division of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 277-277, 2006.

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P3M-24 Mechanisms underlying the impaired EDHF-type relaxations in the mesenteric artery from type 2 diabetic rats

Eri Noguchi, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept. Physiol. and Morphol. , Inst. Med. Chem. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 277-277, 2006.

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P3M-25 Rho-kinase phosphorylates eNOS at Thr495 in vascular endothelial cells, and inactivates it

Masayuki Sugimoto1, Masanori Nakayama2, Takaaki Goto2, Mutsuki Amano2, Kimihiro Komori1, Kozo Kaibuchi2
1Dept. Vascular surgery, Nagoya Univ. Graduate Sch. Med, Nagoya, Japan,, 2Dept. cell pharm. , Nagoya Univ. Graduate Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 278-278, 2006.

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P3M-26 Proteinase-activated receptor (PAR)-1 activation potentiates myofilament Ca2+, sensitivity and induces pulmonary artery contraction

Jun Maki, Katsuya Hirano, Mayumi Hirano, Naohisa Niiro, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol. , Res. Inst. Angiocardiol. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 278-278, 2006.

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P3M-27 Inhibitory action of 1 -stearoyl lysophosphatidic acid on the migration of smooth muscle cells from porcine coronary artery

Misato Uchikawa, Yang-Il Fang, Hisayuki Ohata, Kazuo Honda
Dept. Pharmacol. , Sch. of Pharm. Sci. , Showa Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 278-278, 2006.

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P3M-28 Alterations in contractile response in caudal arterial smooth muscle in type II diabetic Goto-Kakizaki (GK) rats

Takuto Kuramoto, Natsuko Toguchi, Mitsuo Mita, Masaki Saito
Dept. Pharmacodyn. , Meiji Pharmaceutical Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 278-278, 2006.

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P3M-29 Impaired function in rat mesen-teric arteries treated with endotoxin

Tomohiro Miike, Hiroaki Shirahase, Mamoru Kanda, Hiroshi Jino, Kazuyoshi Kurahashi
Pharmacol. Div. , RI Center, Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 279-279, 2006.

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P3M-30 Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1

Hitoshi Tanaka1, Mitsuo Mita2, Kouichi Takeuchi1, Michael P. Walsh3, Masaki Saito2
1Dept. Clin. Pharmacol. , Meiji Pharmaceutical Univ. , Tokyo, Japan,, 2Dept. Pharmacodyn. , Meiji Pharmaceutical Univ. , Tokyo, Japan,, 3Dept. Biochem. & Mol. Biol. and Smooth Muscle Res. Group, Univ. Calgary, Alberta, Canada
Journal of Pharmacological Sciences 100 (suppl.2) 279-279, 2006.

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P3M-31 Characterization of histamine-and serotonin-induced contractions in porcine cerebral and ciliary arteries

Shingo Nagai, Tatsuru Tsurumaki, Hiroshi Higuchi
Div. Pharmacol. , Niigata Univ. Grad. Sch. Med. Dent, Niigata, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 279-279, 2006.

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P3M-32 Analysis of relaxant responses to norepinephrine in swine coronary arteries

Toshihiro Matsuzaki1, Mayuko Sakanashi1, Makiko Sakanashi2, Junko Nakasone1, Matao Sakanashi1
1Dept. Pharmacol. , Sch. Med. , Fac. Med. , Univ. the Ryukyus, Okinawa, Japan,, 2Dept. Anesthesiol. , Scl. , Med. , Fac. Med. , Univ. the Ryukyus, Okinawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 279-279, 2006.

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P3M-33 Alteration of contractile responses in the first and the second branches of mouse mesenteric artery

Chiharu Hagiwara, Koji Nobe, Kazuo Honda
Dept. Phamracol. , Showa Univ. Sch. Pharm. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 280-280, 2006.

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P3M-34 A crucial role of Rac1 in mem-brane targeting of thrombin receptor in vascular smooth muscle cells

Wakako Eto, Katsuya Hirano, Mayumi Hirano, Naohisa Niiro, Junji Nishimura, Hideo Kanaide
Div. Mol. Cardiol. , Res. Inst. Angiocardiol. , Grad. Sch. Med. Sci. , Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 280-280, 2006.

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P3M-35 The importance of Fyn in sphingo-sylphosphorylcholine (SPC)-induced con-traction of vascular smooth muscle cells

Hozumi Kawamichi, Junying Miao, Hiroko Kishi, Katsuko Kajiya, Fengling Guo, Dan Xu, Sei Kobayashi
Dept. Mol. Physiol. , Yamaguchi Univ. , Sch. Med. , Yamaguchi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 280-280, 2006.

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P3M-36 Oxidative stress enhanced a trypsin-induced endothelium-dependent relaxation in the rat aorta

Murasaki Aman, Katsuya Hirano, Mayumi Hirano, Naohisa Niiro, Jyunji Nishimura, Hideo Kanaide
Div. Mol. Cardiol. , Res. Inst. Angiocardiol. , Grad. Sch. Med. Sci, Kyushu Univ. , Fukuoka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 280-280, 2006.

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P3M-37 Angiotensin II enhances contractile responses via P13-kinase p110δ pathway in aortas from diabetic rats with systemic hyper-insulinemia

Tsuneo Kobayashi, Takayuki Matsumoto, Katsuo Kamata
Dept. Physiol. and Morphol. , Inst. Med. Chem. , Hoshi Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 281-281, 2006.

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P3M-38 Proteomic profiling of cultured human coronary smooth muscle cells stimulated with angiotensin II

Yoshiko Tokutomi1, Keiichiro Kataoka1, Norie Araki2, Shokei Kim-Mitsuyama1
1Dept. Pharmacol. & Mol. Ther. , Kumamoto Univ. Grad. Sch. Med. Sci. , Kumamoto, Japan,, 2Dept. Tumor Genet. & Biol. , Kumamoto Univ. Grad. Sch. Med. Sci. , Kumamoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 281-281, 2006.

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P3M-39 Inhibitory effect of azelnidipine, a long-acting dihydropyridine Ca2+ channel antagonist, on in vivo and in vitro experimental coronary spasms

Yuko Sato-Matsuoka1, Michio Fujisawa1, Ryosuke Yorikane2, Tamayo Matsuo3, Takayoshi Kojima3
1Pharmacology and Molecular Biology Res. Labs. , Sankyo Co. , Ltd. , Tokyo, Japan,, 2Pharmacodynamics Res. Labs. , Sankyo Co. , Ltd. , Tokyo, Japan,, 3Institute of Science and Technology, Inc. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 281-281, 2006.

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P3M-40 Influence of experimental SAH on effects of levcromakalin, nifedipine and nico-tinic acetylcholine receptor blockers in nicotine-induced endothelium-dependent contraction (EDC) in rat basilar artery

Xu Ji, Tsuyoshi Nishihashi, Cristina. C. Trandafir, Aimin Wang, Kazuyoshi Kurahashi
Pharmacol. Div. , RI Ctr. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 281-281, 2006.

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P3M-41 Participation of arginine vaso-pressin and leukotrienes in development of cerebral vasospasm after subarachnoid hemorrhage

Cristina. C. Trandafir, Tsuyoshi Nishihashi, Xu Ji, Aimin Wang, Kazuyoshi Kurahashi
Pharmacol. Div. , RI Ctr. , Kyoto Univ. , Kyoto, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 282-282, 2006.

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P3M-42 Roles of chymase in the stenosis after polytetrafluoroethylene grafts implantation

Denan Jin1, Haruhiko Ueda2, Shinji Takai1, Michiko Muramatsu1, Keiichi Furubayashi1, Toshihiko Ibaraki1, Kanta Kishi1, Yoji Katsuoka2, Mizuo Miyazaki1
1Dept. Pharmacol. , Osaka Med. Col. , Osaka, Japan. ,, 2Dept. Urol. , Osaka Med. Col. , Osaka, Japan.
Journal of Pharmacological Sciences 100 (suppl.2) 282-282, 2006.

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P3M-43 Neuronal nitric oxide inhibits the neurogenic norepinephrine release in rat mesenteric resistance arteries

Yukako Hatanaka, Narumi Hobara, Honghua Jin, Toshihiro Koyama, Shinji Akiyama, Fusako Takayama, Hiromu Kawasaki
Dept. Clin. Pharmac. Sci. , Grad. Sch. Med. Den. Phramac. Sci. , Okayama Univ. , Okayama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 282-282, 2006.

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P3N-01 Effect of the phosphodiesterase IV inhibitor rolipram on allergic footpad swelling using various adjuvants

Kouya Yamaki, Hiroyuki Uchida, Yoshiki Harada, Shin Yoshino
Dept. Pharmacol. , Kobe Pharmaceut. Univ. , Kobe, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 282-282, 2006.

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P3N-02 Role for cyclic ADP-ribose in calcium signaling in human neutrophils

Katsuya Morita1, Minoru Saida2, Norimitsu Morioka1, Tomoya Kitayama1, Yasumasa Akagawa2, Toshihiro Dohi1
1Dept. Dental Pharmacol. Hiroshima Univ. Grad. Sch. Biomed. Sci. , Hiroshima, Japan,, 2Dept. Advanced Prosthodontics Hiroshima Univ. Grad. Sch. Biomed. Sci, Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 283-283, 2006.

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P3N-03 Expression of choline acetyltrans-ferase mRNA in mouse antigen-presenting cells

Tomoyoshi Nakano, Yasuhiro Moriwaki, Koichiro Kawashima
Dept. Pharmacol. , Kyoritsu Coll. Pharmacy, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 283-283, 2006.

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P3N-04 Chloride channel 4 (CIC-4) expression on lipopolysaccaride (LPS) stimulation in human B leukemic cells

Kiminobu Sumita1, 2, Naoki Hattori1, Chiyoko Inagaki1
1Dept. Pharmacol. , Kansai. Med. Univ. , Osaka, Japan,, 2Rabiton Institute, Inc. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 283-283, 2006.

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P3N-05 Physiological role and activation mechanism of the oxidative stress-susceptible TRPM2 Ca2+ channel in immunocytes

Shinichiro Yamamoto1, Shunichi Shimizu2, Masakazu Ishii2, Yuji Hara1, Tamio Hagiwara2, Takaharu Negoro2, Motohiro Nishida1, Takashi Tobe2, Yuji Kiuchi2, Yasuo Mori1
1Dept. Synth. and Biol. Chem. , Kyoto Univ. , Kyoto, Japan,, 2Dept. Pathophysiol. Sch. Pharm. Sci. , Showa Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 283-283, 2006.

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P3N-O6 Hydrogen peroxide at a low concentration protects RAW264 cells against hydrogen peroxide-induced apoptosis through the induction of catalase

Yasuhiro Yoshioka, Tatsuya Kitao, Yoshitaka Kouno, Akiko Yamamuro, Sadaaki Maeda
Dept. Pharmacotherap. , Faculty Pharmaceut. Sci. , Setsunan Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 284-284, 2006.

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P3N-07 The mechanisms of catalase induction by nitric oxide and hydrogen per-oxide

Tatsuya Kitao, Yasuhiro Yoshioka, Yoshitaka Kouno, Akiko Yamamuro, Sadaaki Maeda
Dept. Pharmacotherap. , Faculty Pharmaceut. Sci. , Setsunan Univ. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 284-284, 2006.

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P3N-08 MAPK-mediated down regulation of asparagine synthetase during TPA-induced differentiation of HL-60 cells

Ken Hashimoto, Fumika Suzuki, Hiroshi Sakagami
Div. Pharmacol. , Meikai Univ. Sch. Dent. , Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 284-284, 2006.

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P3N-09 Effects of chronic nicotine administration on antibody production in C57BL/6 mice

Kumiko Arimoto, Tomoyoshi Nakano, Ayako Tashiro, Yasuhiro Moriwaki, Hidemi Misawa, Koichiro Kawashima
Dept. of Pharmacol. , Kyoritsu Coll. of Pharmacy. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 284-284, 2006.

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P3N-10 Inhibitory effect of purine derivatives on histamine release in RBL-2H3 cells

Koichiro Ozawa, Toru Hosoi, Fumie Onishi, Michiko Yoshii
Dept. Pharmacother. , Grad. Sch. Biomed. Sci. , Hiroshima Univ. , Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 285-285, 2006.

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P3N-11 Participation of cytokine- and apoptosis-related genes to acute allograft rejection in rats

Kazuhisa Fujita, Shin-ya Yabuki, Hideo Kato, Masami Kato, Hitoshi Kimura, Takao Ota
Nihon Bioresearch Inc. , Gifu, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 285-285, 2006.

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P3N-12 Non-clinical safety and human subject protection during clinical trials of monoclonal antibodies and their analogs for human use

Tamiko Suzuki-Nishimura
Pharmaceuticals and Medical Devices Agency, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 285-285, 2006.

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P3N-13 Possible differential roles of COX-1 and COX-2 products on the later phase of an acute inflammatory model

Masashi Nakano1, Michiko Kawamura2, Ko Hatanaka2, Yoshiteru Harada1
1Dept. Mediator and Signal Transduction Pharmacology, Kitasato Univ. Graduate Sch. of Medical Sciences, Kanagawa, Japan,, 2Dept. Pharmacol. , Kitasato Uinv. Sch. Medicine, Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 285-285, 2006.

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P3N-14 Expression of mRNA encoding prostaglandin D2 synthase and DP receptor in mononuclear leukocytes of C57BL/6J mice

Keiko Toyoizumi, Ken Yoshikawa, Yasuhiro Moriwaki, Hidemi Misawa, Koichiro Kawashima
Dept. Pharmacol. , Kyoritsu Coll. of Pharmacy, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 286-286, 2006.

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P3N-15 Regulation of inflammatory cells by protein transduction of intracellular molecules with inhibitory function

Masahito Ogasawara1, Kohei Yamauchi2, Akira Matsumoto3, Kazutaka Maeyama1
1Div. Pharmacol. Dept. Integrated life science. Ehime Univ. Sch. Med. , Shitsugawa, Japan,, 2Third Dept. Int. Med. Iwate Medical Univ. , Morioka, Japan,, 3Dept. Immunol. and Host defense, Sch. of Med. Ehime Univ. , shitsugawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 286-286, 2006.

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P3N-16 Effect of phosoholipase C (PLC) and cytosolic phospholipaseA2 (cPLA2) in fMLP-induced eosinophil functions

Akiko Sano1, Junichi Hasegawa2, Norimasa Miura2, Hiroyuki Sano1, Yuji Tohda1
1Dept. Respiratory Medicine and Allergology. , Kinki Univ. Sch. Med. , Osaka, Japan,, 2Dept. Pharmacotherapeutics. , Tottori Univ. Sch. Med. , Tottori, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 286-286, 2006.

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P3N-17 Enhancement of EAAC1 -mediated glutamate transport activity by Arl6ip-1

Mitsushi J. Ikemoto1, 2, Saori Akiduki1
1Age Dimension Research Center, AIST, Tsukuba Central 6, Ibaraki, Japan,, 2Graduate School of Science, Toho University, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 286-286, 2006.

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P3N-18 Age-related impairement of the responsiveness of AQP5 to muscarinic ago-nists in rat parotid glands

Gota Cho1, Noriko Inoue4, Yan Pan2, Yoshiko Nakae3, Yasuko Ishikawa4
1Dept. of Dental Anesthesiology, Univ. of Tokushima Graduate School, Tokushima, Japan,, 2Dept. of Pharmacol. Peking Univ. , Beijing, , China,, 3Dept. of Anatomy, Univ. of Tokushima Graduate School, Tokushima, Japan,, 4Dept. of Medical Pharmacol. , Univ. of Tokushima Graduate School, Tokushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 287-287, 2006.

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P3N-19 Thioredoxin interacts with Ras and inhibits GTPase activity through reduction of cysteine oxidation

Makoto Hase1, 2, Akinori Nishi1, Masatoshi Tanaka1, Junichi Sadoshima2
1Dept. Pharmacol. , Kurume Univ. Sch. Med. , Kurume, Japan,, 2Dept. Cell Biol & Mol Med. , UMDNJ. , Newark, U. S. A
Journal of Pharmacological Sciences 100 (suppl.2) 287-287, 2006.

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P3N-20 Possible relation between endo-plasmic reticulum (ER) stress and caspase dependent pathways in glycochenodeoxy-cholic acid (GCDCA) induced apoptosis in human hepatoma cell line, HepG2

Toru Iizaka, Mayumi Tsuji, Shizuma Tsuchiya, Shusuke Momma, Katsuji Oguchi
Dept. Pharmacol. , Showa Univ. Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 287-287, 2006.

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P3N-21 Novel surrogate ligands that stimulate human P2Y 12 receptors were identified by in silico and in vitro fusion methods

Kiyoshi Baba1, Yousuke Nonaka1, Takeshi Hiramoto2, Norihisa Fujita1
1Dept. Bioinformatics, Fac. Info and Sci. , Ritsumeikan Univ. , Kusatsu, Japan,, 2Dept Pharmacology, National Defense Medical College, Saitama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 287-287, 2006.

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P3N-22 Amlodipine, a dihydropyridine Ca2+, channel blocker, induces G1 cell-cycle arrest in human epidermoid carcinoma A431 cells

Junko Yoshida, Takaharu Ishibashi, Matomo Nishio
Dept. Pharmacol. , Kanazawa Med. Univ. , Ishikawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 288-288, 2006.

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P3N-23 N-acetyl-cysteine enhances growth in chronic myeloid leukemia onco-protein, BCR-ABL-transformed cells

Fujiko Tsukahara, Yoshiro Maru
Dept. Pharmacol. , Tokyo Women's Med. Univ. , Sch. Med. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 288-288, 2006.

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P3N-24 Role of interaction between Filamin and CRMP2 in Semaphorin 3A signaling

Yuichi Nakayama1, Emiko Kuramata1, Yutaka Uchida1, Ken-ichi Ogura1, Fumio Nakamura1, Kohtaro Takei1, 2, Yoshio Goshima1, 2
1Dept. Mol. Pharmacol. & Neurobiol. , Yokohama City Univ. Grad. Sch. Med. , Yokohama, Japan,, 2JST. CREST, Kawaguchi, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 288-288, 2006.

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P3N-25 Isolation and identification of signal molecules interacting directly with endothelin receptors

Manabu Nakano, Misato Hayashi, Ligyun Lu, Osamu Takikawa, Tadashi Nishiya, Souichi Miwa
Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Spporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 288-288, 2006.

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P3N-26 Isolation and preliminary characterization of a dorsal lectin from the redfin velvetfish, Hypodytes rubripinnis

Takefumi Hosotani1, Hideyuki Nakagawa1, Yuka Nakano1, Atsumi Harada1, Hitomi Sakai1, Ryushi Kawakami2, Shuichiro Goda2, Haruhiko Sakuraba2, Toshihisa Ohshima2, Kuniko Nagasaka3
1Dept. of Life Sci. , Univ. of Tokushima, Tokushima, Japan,, 2Dept. of Biol. Sci. and Tech. , Univ, of Tokushima, Tokushima, Japan,, 3Fukae Nagasaka Clinic, Hiroshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 289-289, 2006.

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P3N-27 Selective allosteric ligand activation of the retinoid X receptor heterodimers of NGFI-B and Nurr1

Kentaro Morita1, Katsuyoshi Kawana2, 3, Mariko Sodeyama3, Iichiro Shimomura1, 2, Hiroyuki Kagechika4, Makoto Makishima1, 2, 3
1Dept. Med. Pathophysiol. , Grad. Sch. Front. Biosci. , Osaka Univ. , Osaka, Japan,, 2Dept. Pathol. Pathophysiol. , Grad. Sch. Med. , Osaka Univ. , Osaka, Japan,, 3Dept. Biochem. , Nihon Univ. Sch. Med. , Tokyo, Japan,, 4Sch. Biomed. Sci. , Tokyo Med. Dent. Univ. , Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 289-289, 2006.

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P3N-28 c-YES specific inhibition by ebse-len: A target discovery through the compre-hensive analysis of human protein-drug interactions

Tsuruki Tamura, Masato Umehara, Ken Horiuchi, Yuko Isono, Hironori Osaki, Morikazu Kito, Ai Wakamatsu, Jun-ichi Yamamoto, Yorimasa Suwa
Reverse Proteomics Research Institute Co. , Ltd. , Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 289-289, 2006.

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P3N-29 Effects of reactive sulfur species on the conversion of xanthine dehydrogenase (XD) to oxidase (XO) in the liver

Satoru Sakuma1, Shun-ich Wada2, Yohko Fujimoto1
1Lab. Physiol. Chem. Osaka Univ. Pharmaceut. Sci. , Osaka, Japan,, 2Lab. Medicinal Chem. Osaka Univ. Pharmaceut. Sci. , Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 289-289, 2006.

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P3N-30 Effects of endocrine disruptors on the formation of prostaglandin and arachi-donoyl-CoA formed from arachidonic acid in kidney medulla microsomes

Yohko Fujimoto, Satoru Sakuma
Lab. Physiol. Chem. Osaka Univ. Pharmaceut. Sci, Osaka, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 290-290, 2006.

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P3N-31 Effects of cholesterol biosynthe-sis-associated compounds on HRD1 expression and protection against hypoxia-induced cell death

Naoki Takamura1, Masayuki Kaneko2, Takashi Uehara1, Masabumi Minami1, Yasuyuki Nomura3
1Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Hokkaido Univ. , Sapporo, Japan,, 2Dept. Pharmacol. , Fac. Pharm. Sci. , Chiba Institute of Science, Chiba, Japan,, 3Hokkaido Univ. Grad. Sch. Med. , sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 290-290, 2006.

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P3N-32 Statistical estimation of drug-receptor model parameters

Yasunori Aoki1, 2, Chikuma Hamada2, Isao Yoshimura2
1Pharmaceutical Development Administration Department, Tokyo, Japan,, 2Faculty of Engineering, Tokyo University of Science, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 290-290, 2006.

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P3N-33 Proteomic expression profiling of liver toxicity in rat in 28-day repeated dose study

Hidenori Yamanaka1, Yasushi Minobe1, Masanori Otsuka1, Yoshikuni Yakabe1, Koichi Saito2, Masaru Sekijima3, Tomoyuki Shirai4
1Chemicals Evaluation and Research Institute, Japan, Saitama, Japan,, 2Sumitomo Chemical Co. , Ltd. , Osaka, Japan,, 3Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, Japan,, 4Graduate School of Medical Sciences, Nagoya City Univ. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 290-290, 2006.

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P3N-34 Molecular characterization of chicken neuromedin B and its receptor

Masayuki Shibayama, Hiroki Saito, Kazuhiko Inoue, Shin-ichi Iwata, Takao Shimizu, Atsuro Miyata
Dept. Pharmacol. , Kagoshima Univ. Grad. Sch. Med. Dent. Sci. , Kagoshima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 291-291, 2006.

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P3N-35 Duplicated α7 nicotinic receptor gene product directly interacts with α7 receptor in human SH-SY5Y neuroblastoma cells

Kazue Takagi, Hiroshi Tsuneki, Soushi Kobayashi, Masako Ogawa, Tsutomu Wada, Toshiyasu Sasaoka
Dept. Clin. Pharmacol. , Univ. of. Toyama, toyama, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 291-291, 2006.

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P3N-36 Renal specific chloride channel CIC-5 is regulated by the transcription factor HNF1α

Karo Tanaka1, Marco Pontoglio2, Toshio Nakaki1
Dept. Pharmacol. , Teikyo Univ. Sch. Med. , Tokyo, Japan,, 2Gene Expression Unit, Dept. developmental biology, Pasteur Institute, Paris, France
Journal of Pharmacological Sciences 100 (suppl.2) 291-291, 2006.

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P3N-37 Effects of a nonsense-mediated mRNA decay inhibitor on a splice variant with PTCs

Yayoi Shikama Huiyuan Hu, Isao Matsuoka, Junko Kimura
Dept. Pharmacol. , Fukushima Medical Univ. Sch. Med. , Fukushima, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 291-291, 2006.

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P3N-38 Inducible expression of dominant-negative CREB by Tet-On system suppressed lens differentiation during zebrafish development

Hisashi Takeda, Tomoyuki Yoshida, Naoto Matsuda, Masayoshi Mishina
Dept. Mol. Neurobiol. & Pharmacol. Grad. Sch. Med. Univ. Tokyo. and SORST/JST, Tokyo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 292-292, 2006.

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P3N-39 Technology for high-throughput RNAi library construction

Dai Tadokoro, Kohtaroh Sugao, Kenzo Hirose
Dept. Cell Physiol. , Nagoya Univ. Grad. Sch. Med. , Nagoya, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 292-292, 2006.

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P3N-40 Comprehensive analysis of bHLH-PAS proteins by using the wheat germ extract expression system and SPR biosen-sors

Masato Umehara, Morikazu Kito, Tsuruki Tamura, Yuko Isono, Ai Wakamatsu, Jun-ichi Yamamoto, Yorimasa Suwa
Reverse Proteomics Research Institute Co. , Ltd, Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 292-292, 2006.

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P3N-41 Identification and characterization of novel ubiquitin ligases involved in ER-associated degradation (ERAD)

Ikuko Iwase1, Masayuki Kaneko1, 2, Takashi Uehara1, Masabumi Minami1, Yasuyuki Nomura1, 3
1Dept. Pharmacol. , Grad. Sch. Pharm. Sci. , Hokkaido Univ. , Sapporo, Japan,, 2Dept. Pharmacol. , Fac. Pharma. Sci. , Chiba Institute of Science, Chiba, Japan,, 3Hokkaido Univ. Grad. Sch. Med. , Sapporo, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 292-292, 2006.

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P3N-42 A possibility as an anticancer agent using hTERT-regulating gene on human chromosome 10

Reina Sato, Tomoe Tsukamoto, Shunsaku Takahashi, Tomomi Harada, Akiko Matsuda, Norimasa Miura, Junichi Hasegawa
Div. Pharmacotherapeutics. Dept. pathophysiological and Therapeutic Science. , Tottori Univ. Sch. Med. , Tottori, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 293-293, 2006.

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P3N-43 Caffeine perturbs mRNA expression of AP-1 transcription factors and iodide transporters in BeWo cell cultures and rat placenta

Shigeno Saito1, 2, Yoshimitsu Abiko1, 2
1Dept. Biochem. Molecul. Biol. , Nihon Univ. Sch. Dent. at Chiba, Japan,, 2Res. Inst. Oral Sci, Nihon Univ. Sch. Dent. at Chiba, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 293-293, 2006.

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P3N-44 Systematic multi genotyping for drug metabolizing enzyme and drug transporter in human in liver

Sachiko Nakaya1, Shihoko Sakurai1, Toshio Kumai1, Hiroshi Nakano2, Takeshi Asakura2, Naoki Matsumoto1, Takehito Otubo2, Shinichi Kobayashi1
1Dept. Pharmacol. , St. Marianna Univ. Sch. Med. , Kanagawa, Japan,, 2Dept. Gastro-instinal General Surgey. , St. Marianna Univ. Sch. Med. , Kanagawa, Japan
Journal of Pharmacological Sciences 100 (suppl.2) 293-293, 2006.

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