Journal of Pharmacological Sciences 109巻 suppl.2号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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P1O-A1-1 Potentiation of TRPC5 channel activity by Ca2+

Minoru Wakamori1, Takashi Yoshida1, Shinichiro Yamamoto2, Yasuo Mori2
1Dept.Oral Biol., Tohoku Univ, Grad.Sch.Dent., 2Dept.Synth.Chem.& Biol.Chem., Kyoto Univ., Grad.Sch.Engin., Kyotodaigaku-Katsura
Journal of Pharmacological Sciences 109 (suppl.2) 124-124, 2009.

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P1O-A1-2 Molecular basis for differential drug sensitivity of Kir channels

Kazuharu Furutani, Atsushi Inanobe, Yoshihisa Kurachi
Dept.Pharmacol., Grad.Sch.Med., Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 124-124, 2009.

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P1O-A1-3 LPS-induced transglutaminase 2 expression and the involvement of NO production in cultured astrocytes

Katsura Takano, Kensuke Shiraiwa, Mitsuaki Moriyama, Yoichi Nakamura
Lab.Integrative Physiology, Vet.Sci., Osaka Pref.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 124-124, 2009.

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P1O-A1-4 Glucagon-like peptide-2 increases BDNF expression in glia

Yumiko Yoshitake1, Takashi Iwai1, 2, Jun-Ichiro Oka1
1Dept.Pharmacol., Fac.Pharm.Sci., Tokyo Univ.Sci., 2Nat'l.Inst.Mental Health, NCNP
Journal of Pharmacological Sciences 109 (suppl.2) 124-124, 2009.

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P1O-A1-5 Extracellular ATP elicits the expression of BDNF exon IV mRNA in rat astrocytes

Ichiro Takasaki1, Satoko Takarada2, Saori Tatsumi2, Aiko Azegami2, Makoto Yasuda2, Akiko Tabuchi2, Takashi Kondo3, Yoshiaki Tabuchi1, Masaaki Tsuda2
1Div.Mol.Gen.Res., Life Sci.Res.Ctr., Univ.Toyama, 2Dept.Biol.Chem., Univ.Toyama, 3Dept.Radiol.Sci., Univ.Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 125-125, 2009.

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P1O-A1-6 Chronic administration of ketamine changes the gene expressions of the D-serine-related enzymes

Mariko Watanabe1, Masanobu Yoshikawa2, Kazuhide Takeyama1, Tomohiko Murata1, Xing-Lu Jin2, Tomomi Kobayashi2, Atsushi Hashimoto2, Hiroyuki Kobayashi2, Toshiyasu Suzuki1
1Dept.Anesthesiol., Tokai Univ.Sch.Med., 2Dept.Clinical Pharmacol., Tokai Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 125-125, 2009.

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P1O-A1-7 Nicotine enhances the expression of synaptotagmin1 in mouse hippocampus

Takaaki Nishimoto1, Keiichi Kadoyama1, Taizo Taniguchi1, Akira Matsumoto1, 2, Shogo Matsuyama1
1Dept.Pharmaceu.Health Care., Dokkyo Univ., 2Trans.Res.Info.Center
Journal of Pharmacological Sciences 109 (suppl.2) 125-125, 2009.

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P1O-A1-8 Effect of the free radical scavenger on survival of newly generated cells after neuronal damage in the hippocampal dentate gyrus

Masanori Yoneyama, Koichi Kawada, Kiyokazu Ogita
Dept.Pharmacol., Setsunan Univ.Pharmaceutical Sci
Journal of Pharmacological Sciences 109 (suppl.2) 125-125, 2009.

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P1O-A2-1 GPCR signal crosstalk regulates mGluR1 signaling and LTD in cerebellar Purkinje cells

Yuji Kamikubo1, 2, Toshihide Tabata3, Yosuke Fujita3, Takeshi Shimomura3, Takashi Sakurai1, Masanobu Kano2
1Dept.Pharmacol., Juntendo Univ.Sch.Med., 2Dept.Neurophysiol., Grad.Sch.Med., Univ.Tokyo, 3Fac.Eng., Univ.Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 126-126, 2009.

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P1O-A2-2 Mutant γPKC found in spinocerebellar ataxia type 14 affects the lysosomal protein degradation system

Takahiro Seki1, Kazuhiro Yamamoto1, Kota Ogawa1, Naoaki Saito2, Noboru Mizushima3, Norio Sakai1
1Dept.Mol.Pharmacol.Neurosci., Grad.Sch.Biomed.Sci., Hiroshima Univ., 2Lab.Mol.Pharmacol., Biosig.Res.Ctr., Kobe Univ., 3Dept.Phisiol.Cell Biol., Grad.Sch.Facl.Med., Tokyo Med.Dent.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 126-126, 2009.

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P1O-A2-3 The roles of glutamate transporter, GLAST in learning and memory, and emotion

Yukari Waki1, Rina Murai2, Akira Yoshimi1, Shinnosuke Yamada1, Yu Ando1, Akihiro Mouri2, Norio Ozaki3, Kiyofumi Yamada4, Kohichi Tanaka5, Yukihiro Noda1, Toshitaka Nabeshima2
1Divi.Clin.Sci.Neuropsychopharmacol., Meijo Univ.Grad.Sch.Pharm.Sci., 2Dept.Chem.Pharmacol., Meijo Univ.Grad.Sch.Pharm.Sci, 3Dept.Psychiatr., Nagoya Univ.Grad.Sch.Med., 4Dept.Neuropsychopharmacol.and Hospital Pharm., Nagoya Univ.Grad.Sch.Med., 5Dept.Mol.Neurosci., Tokyo Medical and Dental Univ.Sch.Biomed.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 126-126, 2009.

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P1O-A2-4 SIRT1 affects differentiation of PC12 cells by nerve growth factor

Mitsuhisa Maruyama, Yoshiyuki Horio
Dept.Pharmacol., Sapporo Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 126-126, 2009.

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P1O-A2-5 Prostaglandin E2 inhibits amyloid β25-35-induced phagocytosis in cultured rat microglia

Takayuki Nagano, Shinya H.Kimura, Motohiko Takemura
Dept.Pharmacol., Hyogo Col.Med
Journal of Pharmacological Sciences 109 (suppl.2) 127-127, 2009.

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P1O-A2-6 Functional changes of neurofilament-L in the hippocampus of mouse with amnesia induced by the i.c.v.-injection of Abeta

Tursun Alkam1, 2, Atsumi Nitta2, Hiroyuki Mizoguchi2, 3, Akio Itoh2, Rina Murai2, Taku Nagai2, Kiyofumi Yamada2, Toshitaka Nabeshima1, 2
1Dept.Chemical Pharmacol.Grad Sch Pharm Sci.Meijo Univ, 2Dept.Neuropsychopharm., Nagoya Univ.Grad.Sch.Med., 3FESC, Res Inst Environ Med, Nagoya Univ
Journal of Pharmacological Sciences 109 (suppl.2) 127-127, 2009.

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P1O-A2-7 The mechanisms of endoplasmic reticulum stress-induced leptin-resistance:The effect of SOCS3 and PTP1B

Toru Hosoi, Miyako Sasaki, Chie Hashimoto, Tsuyoshi Miyahara, Suguru Matsuo, Michiko Yoshii, Koichiro Ozawa
Dept.Pharmacotherapy., Grad.Sch.Biomed.Sci.Hiroshima Univ
Journal of Pharmacological Sciences 109 (suppl.2) 127-127, 2009.

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P1O-A2-8 Effects of retinoid ligands on dopaminergic neuroprotection and BDNF expression

Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki
Dept.Chemico-Pharmacol.Sci., Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 127-127, 2009.

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P1O-A3-1 Dopamine inhibits NO production by LPS-activated microglia through the formation of quinoprotein

Yasuhiro Yoshioka, Azusa Tozawa, Tadahiro Kitamoto, Akiko Yamamuro, Atsushi Kasai, Sadaaki Maeda
Dept.Pharmacotherap., Faculty Pharmaceut.Sci., Setsunan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 128-128, 2009.

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P1O-A3-2 Regulation of microglial amyloid-β phagocytosis by anti-amyloid-β antibody

Kazuyuki Takata, Yoshihisa Kitamura, Takashi Taniguchi
Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 128-128, 2009.

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P1O-A3-3 Pathological roles of TRPV4 in microglial activation

Hisashi Shirakawa, Ikkei Matsutani, Masakazu Konno, Takayuki Nakagawa, Shuji Kaneko
Dept.Mol.Pharmacol., Grad.Sch.Pharm.Sci., Kyoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 128-128, 2009.

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P1O-A3-4 Role for glial cytokine in morphine-3-glucronide-induced allodynia

Takaaki Komatsu1, Sou Katsuyama1, Kengo Sanai2, Chikai Sakurada3, Shinobu Sakurada2, Tsukasa Sakurada1
1Dept.Pharmacol., Daiichi Coll.Pharmaceu.Sci., 2Dept.Physiol.Anat, Tohoku Pharmaceu.Univ., 3Dept.Biochem., Nihon Pharmaceu.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 128-128, 2009.

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P1O-A3-5 Noradrenaline attenuates hydrogen peroxide-induced cell death of astrocyte through the increase in the level of intracellular glutathione

Hisatsugu Kadoi, Yasuhiro Yoshioka, Akiko Yamamuro, Atsushi Kasai, Sadaaki Maeda
Dept.Pharmacotherap., Faculty Pharmaceut.Sci., Setsunan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 129-129, 2009.

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P1O-A3-6 Early changes in astrocytes after rotenone exposure

Naotaka Kimoto1, Saki Fukuoka2, Yuri Kikkawa1, Francisco.J.Diaz-Corrales1, Ikuko Miyazaki1, Masato Asanuma1
1Dept.of Brain Sci., Okayama Univ.Grad.Sch.of Med., Dent.and Phamaceut.Sci., 2Dept.of Clinical Pharm., Okayama Univ.Grad.Sch.of Med., Dent.and Phamaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 129-129, 2009.

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P1O-A3-7 Functional role of microglia and microsomal prostaglandin E synthase-1 in a mouse model for amyotrophic lateral sclerosis

Hiroko Miyagishi1, Yasuhiro Kosuge1, Kumiko Ishige1, Shin-ichi Ono2, Yoshihisa Ito1
1Research Unit of Pharmacol., Dept.of Clinical Pharm., Coll.of Pharm., Nihon Univ., 2Research Unit of Clinical Pharm., Dept.of Clinical Pharm., Coll.of Pharm., Nihon Univ
Journal of Pharmacological Sciences 109 (suppl.2) 129-129, 2009.

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P1O-A3-8 Regulation of thrombin-induced neurotoxicity and microglial activation in cortico-striatal slice culture by long-term nicotine treatment

Masatoshi Ohnishi1, Hiroshi Katsuki2, Mikako Takagi1, Toshiaki Kume1, Yasuhiko Izumi1, Akinori Akaike1
1Dept.Pharmacol., . Grad.Sch.Pharm.Sci., Kyoto Univ., 2Dept.Chemico-Pharmacol.Sci., Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 129-129, 2009.

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P1O-A4-1 Effect of cisplatin on vomiting reflex and hypothalamic glutamate release in Suncus murinus

Kouichi Yamamoto1, Sze Wa Chan2, Keiko Asano1, John Rudd2, Atsushi Yamatodani1
1Division of Health Sciences, Graduate School of Medicine, Osaka University, 2Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong
Journal of Pharmacological Sciences 109 (suppl.2) 130-130, 2009.

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P1O-A4-2 Bromocriptine inhibits excitatory amino acid release mediated by glutamate transporter reversal without affecting uptake

Yasufumi Shirasaki1, Toshiyuki Sato2
1Pharmacology Research Laboratories, Daiichi-Sankyo Co., Ltd., 2Biol.Res.Labs
Journal of Pharmacological Sciences 109 (suppl.2) 130-130, 2009.

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P1O-A4-3 Induction of presynaptic differentiation by the extracellular N-terminal domain of glutamate receptor δ2

Takeshi Uemura, Masayoshi Mishina
Dept.of Mol.Neurobiol.& Pharmacol., Grad.Sch.of Med., Univ.of Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 130-130, 2009.

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P1O-A4-4 L-DOPA affects field excitatory postsynaptic potentials in rats NTS

Momo Fujii1, Yasuhiro Murota1, Yoshinori Kamiya2, Yoshio Goshima1
1Dept.Mol.Pharmacol.& Neurobiol., Yokohama City Univ.Sch.Med., 2Dept.Anesthesol.& critical care Med., Grad Sch.Med., Yokohama City Univ
Journal of Pharmacological Sciences 109 (suppl.2) 130-130, 2009.

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P1O-A4-5 Protein SUMOylation as a novel mechanisms for synaptic transmission regulation

Atsushi Nishimune1, Stephane Martin2, Marco Feligioni2, Jack Mellor2, Henley Jeremy2
1Dept.Biochem.& Bioinformative Sci., Dev.Pharmacol., 2MRC Centre for Synaptic Plasticity, Univ.of Bristol, University Walk
Journal of Pharmacological Sciences 109 (suppl.2) 131-131, 2009.

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P1O-A4-6 Functional analysis of substance P release in rat brain

Yoki Nakamura, He-Bin Tang, Kanako Miyano, Norimitsu Morioka, Atsuko Inoue, Yoshihiro Nakata
Dept.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 131-131, 2009.

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P1O-A4-7 Involvement of presynaptic serotonergic system inρ-hydroxyamphetamine-induced prepulse inhibition deficits

Hiroshi Onogi1, Osamu Nakagawasai1, Satoru Mitazaki2, Atsushi Sato1, Yuichiro Arai3, Fukie Niijima1, Koichi Tan-No1, Takeshi Tadano1
1Dept.Pharmacol., Tohoku Pharmaceut. Univ., 2Lab.Foren.Toxicol., Facl.Pharmacy, Takasaki Univ.of Health and Welfare, 3Division of Pharmacol., Sch.of Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 131-131, 2009.

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P1O-A4-8 Potentiating effect of spinosin on pentobarbital hypnosis is increased by 5-HT1A antagonist p-MPPI and decreased by 5-HT1A agonist 8-OH-DPAT

Yong-He Zhang, Li-En Wang, Xiao-Rong Shi, Jie-Xin Cao, Su-Ying Cui, Xiang-Yu Cui
School of Basic Medical Science, Peking University
Journal of Pharmacological Sciences 109 (suppl.2) 131-131, 2009.

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P1O-A5-1 Neuroprotective effect of DJ-1 ligands against oxidative stress

Yoshihisa Kitamura1, Takashi Yanagida1, Kazuyuki Takata1, Takashi Taniguchi1, Hiroyoshi Ariga2
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2Dept.Mol.Biol., Grad.Sch.Pharm.Sci., Hokkaido Univ
Journal of Pharmacological Sciences 109 (suppl.2) 132-132, 2009.

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P1O-A5-2 Functional correlates between the stress-induced synaptic response and anxiety-related behavior in early postnatal stressed male and female rats

Chika Judo1, Machiko Matsumoto1, Riki Hirata2, Hirokazu Matsuzaki2, Taku Yamaguchi2, Takeshi Izumi2, Mitsuhiro Yoshioka2, Hiroko Togashi1
1Dept.Pharmacol., Fac.of Pharm.Sci., Health Sci.Univ.of Hokkaido, 2Dept.Neuropharmcol., Hokkaido Univ.Grad.Sch.of Med
Journal of Pharmacological Sciences 109 (suppl.2) 132-132, 2009.

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P1O-A5-3 Involvement of inflammatory cytokines in learning and memory impairment induced by water-immersion restraint stress

Yukari Takahashi1, Anna Amano2, Mio Kawamura2, Masaya Miwa1, Toshitaka Nabeshima2, Masayuki Hiramatsu1, 2
1Lab.of Neuropsychopharmacol., Grad.Sch.of Environ.and Human Sci., Meijo Univ., 2Dept.of Chem.Pharmacol., Fac.of Pharmac., Meijo Univ
Journal of Pharmacological Sciences 109 (suppl.2) 132-132, 2009.

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P1O-A5-4 Involvement of endogenous opioid system in nicotine-induced antinociception and physical dependence in mice

Yuka Kobayashi, Keiko Ueno, Norikazu Kiguchi, Takehiko Maeda, Chizuko Yamamoto, Shiroh Kishioka
Dept.Pharmacol., Wakayama Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 132-132, 2009.

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P1O-A5-5 Expression of p-CREB within the brain in perinatally tobacco smoke-exposed rats

Akiko S.Shingo1, Yuki Moriyasu1, Shozo Kito2
1Hyogo Univ.Sch.of Health Sci., 2Junshin-kai Kousei Rehab Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 133-133, 2009.

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P1O-A5-6 Role of mitochondria in the dentate network formation

Soichiro Nakahara, Norio Matsuki, Ryuta Koyama
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 133-133, 2009.

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P1O-A5-7 Mitochondrial dynamics in the hippocampal mossy fiber morphogenesis

Kentaro Tao, Norio Matsuki, Ryuta Koyama
Lab.Chem.Pharmacol., Grad.Sch.Pharm Sci., The Univ.Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 133-133, 2009.

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P1O-A5-8 Formation mechanism of "Nicotine Dependence"-Analysis on the reason of smoking assessment score and nicotine withdrawal symptoms score

Yuta Kobayashi, Sultana Razia
Dept.Fundament.Nursing, Fac.Med.Shimane Univ
Journal of Pharmacological Sciences 109 (suppl.2) 133-133, 2009.

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P1N-A7-1 Histamine H3-receptors downregulates AT1-receptors in ischemia/reperfusion

Narumi Hobara1, Hiromu Kawasaki2, Roberto Levi3
1Dept.life Sci., Okayama Univ.Sci., 2Dept.Clin.Pharmc.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ., 3Dept.Pharmacol., Weill Medical Cornell Univ
Journal of Pharmacological Sciences 109 (suppl.2) 134-134, 2009.

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P1N-A7-2 TNF-α induces the calcification of human aortic valve interstitial cells obtained from patients with calcific aortic stenosis

Zaiqiang Yu1, 2, Kazuhiko Seya1, Kazuyuki Daitoku2, Shigeru Motomura1, Ikuo Fukuda2, Ken-Ichi Furukawa1
1Dept.Pharmacol., Hirosaki Univ.Grad.Sch.Med., 2Dept.Thorac.Cardiovasc.Surg., Hirosaki Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 134-134, 2009.

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P1N-A7-3 Human urate transporter 1(URAT1)mediates the transport of orotic acid

Daisaku Miura1, 2, Naohiko Anzai2, Ai Tsukada2, Toru Kimura2, Toshiyuki Fukutomi2, Ken-ichi Kiyomiya1, Hiroyuki Sakurai2, Hitoshi Endou2
1Dept.Pharm., Hyogo Univ.Health Sci, 2Dept.Pharmacol.Toxicol., Kyorin Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 134-134, 2009.

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P1N-A7-4 Detection of mRNAs in the urine from rats with chemical-induced nephrotoxicity:Potential biomarkers for kidney injury

Akiko Tsuji, Takako Iwachidou, Chisato Takahara, Naomi Inui, Kenji Takami, Ryoetsu Imai
Development Research Center, Takeda Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 134-134, 2009.

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P1N-A7-5 Loss of function in Hypoxia inducible factor-1 α impaired the ability to ameliorate acute tubular necrosis in ischemic acute renal failure

Shuhei Tomita1, Kunihisa Yamaguchi1, Keisuke Ishizawa1, Yuko Imamura1, Yayoi Fukuhara1, Koichiro Tsutiya2, Toshiaki Tamaki1
1Dept.Pharmacol., Inst.Healthbiosciences, Univ.Tokushima Grad.Sch., 2Dept.Medical Pharmacol., Inst.Healthbiosciences, Univ.Tokushima Grad.Sch
Journal of Pharmacological Sciences 109 (suppl.2) 135-135, 2009.

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P1N-A7-6 Agmatine ameliorates ischemia/reperfusion-induced renal injury by suppressing apoptotic cell death

Takahiro Sugiura1, Yasushi Hirasawa1, Yuichiro Nishida1, Yukari Matsui1, Yukiko Kawasaki1, Tohru Toyoshi1, Kohei Kyuki1, Yasuo Matsumura2
1Nihon Bioresearch Inc., 2Lab.Pathol.and Mol.Pharmacol., Osaka Univ.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 135-135, 2009.

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P1N-A7-7 The effects of heme oxygenase-1 induction on diabetic nephropathy in KK-Ay mice

Yoshinori Iba, Yuki Hirose, Sayaka Kinugawa, Tohru Masukawa
Dept.Pathophysiol.Sci., Fac.Pharm.Sci., Setsunan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 135-135, 2009.

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P1N-A7-8 ETA-dependent natriuresis in renal medulla

Daisuke Nakano1, 2, Akira Nishiyama2, David Pollock1
1Vasc.Biol.Center, Med.Coll.of Georgia, 2Dept.Pharmacol., Kagawa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 135-135, 2009.

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P1N-A8-1 Involvement of ARF1 in 5-hydroxytryptamine(5-HT)-induced internalization of the 5-HT2A receptor expressed in HEK293 cells

Masamichi Ohkura1, Ikuo Norota1, Naoko Tanaka2, Ryuichi Yamamoto2, Kuniaki Ishii1
1Dept.Pharmacol., Yamagata Univ.Sch.Med., 2First Dept.Pharmacol., Sch.Pharmaceut.Sci., Kyushu Univ.Hlth.Welfare
Journal of Pharmacological Sciences 109 (suppl.2) 136-136, 2009.

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P1N-A8-2 Study on mechanisms of hypertension in rat adult offspring following prenatal exposure to immuno-inflammatory stimulants

Zhou Jian-Zhi, Li Xiao-Hui
Dept.Pharm., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 136-136, 2009.

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P1N-A8-3 The influence of feeding phosphatidylserine on the blood vessel function

Ohkubo Takeshi1, 3, Hideyo Tokuoka3, Masaru Shoji2, Mitsuo Mita2, Kiyoto Motojima3
1Functional Food Research Lab., NOF Corporation, 2Dept.Pharmacodyn., Meiji Pharmaceutical Univ., 3Dept.Biochemistry., Meiji Pharmaceutical Univ
Journal of Pharmacological Sciences 109 (suppl.2) 136-136, 2009.

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P1N-A8-4 Transfection of Kir6.2 channel genes into vascular smooth muscle using nanobubbles and ultrasound

Kazuomi Iwasa1, 2, Hai-Lei Zhu1, Atsushi Shibata1, Maki Takai1, 2, Hiroyuki Ito2, Tetsuya Kodama3, Yoshihiko Maehara2, Noriyoshi Teramoto1
1Dept.Pharmacol., Kyushu Univ.Grad.Sch.Medical Sciences, 2Dept of Surg and Science2, 3Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University
Journal of Pharmacological Sciences 109 (suppl.2) 136-136, 2009.

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P1N-A8-5 Effects of in vivo and in vitro treatment with endotoxin on inflammatory cytokines and arterial functions in rat mesenteric arteries

Tomohiro Miike1, Mamoru Kanda1, Kazuyoshi Kunishiro1, Masaki Fukui1, Hiroaki Shirahase1, Kazuyoshi Kurahashi2
1Research Laboratories, Kyoto Pharmaceutical Industries, Ltd., 2Pharmacology Division, RI center, Kyoto University
Journal of Pharmacological Sciences 109 (suppl.2) 137-137, 2009.

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P1N-A8-6 Effects of a novel adipokine visfatin on contraction of isolated blood vessel

Naoko Hara, Hideyuki Yamawaki, Muneyoshi Okada, Yukio Hara
Lab.Vet.Pharmacol., Kitasato Univ.Sch.Vet.Med
Journal of Pharmacological Sciences 109 (suppl.2) 137-137, 2009.

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P1N-A8-7 Action of CRP on nitric oxide(NO)production in human coronary artery endothelial cell

Naoaki Arai1, Mitsuo Mita1, Shigeru Hishinuma1, Reiko Ishii-Nozawa2, Koichi Takeuchi2, Masaru Shoji1
1Dept.Pharmacodyn., Meiji Pharmaceut.Univ., 2Dept.Clin.Pharmacol., Meiji Pharmaceut.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 137-137, 2009.

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P1N-A8-8 Thyroid hormone targets genes associated with arterial elasticity

Sachiko Yanagino1, 2, Mitsutoshi Satoh1, Kazuhiro Suzuki2, Tomoko Nishimaki-Mogami3, Yoji Sato2
1Dept.Toxicol Pharmacol., Fac.Pharmaceytical.Sci., Toho Univ., 2Div.Cell.Gene Thpy Prod., NIHS, 3Div.Biochem.Immunochem., NIHS
Journal of Pharmacological Sciences 109 (suppl.2) 137-137, 2009.

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P1N-A9-1 The superoxide generation through uncoupled eNOS in the cardiac hypertrophy

Yingmei Lu1, Kohji Fukunaga1, 2, Feng Han1, 3
1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 2Tohoku Univ.21st Century COE Program, 3Institute of Pharmacology & Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 109 (suppl.2) 138-138, 2009.

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P1N-A9-2 Involvement of PDE2 in the inhibitory effect of progesterone on cAMP-stimulated cardiac L-type Ca2+ currents

Emika Kurobane1, 2, Junko Kurokawa2, Takeshi Suzuki1, Tetsushi Furukawa2
1Dept.Basic Biol Sci., Keio Univ.Pharm., 2Dept.Bio-informational Pharmacol., MRI, Tokyo Med Dent Univ
Journal of Pharmacological Sciences 109 (suppl.2) 138-138, 2009.

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P1N-A9-3 The function of PDZRN3 in cardiac myocytes

Yoshihiro Kimura, Makoto Inui
Dept.Pharmacol., Yamaguchi Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 138-138, 2009.

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P1N-A9-4 Adenosine production and its role in protection against ischemic and reperfusion injury of the myocardium

Toshio Obata
Dept.Anal.Cnem.Ohu Univ.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 138-138, 2009.

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P1N-A9-5 Analyses for effects of Apelin on left ventricular contractility in ex vivo mouse hearts

Susumu Fujisawa1, Keiji Kuba2, Akinori Kimura2, Yumiko Imai1
1Dept.Pharmacol., Akita Univ.Sch.Med, 2Medical Research Institute, Tokyo Med.and Dental Univ
Journal of Pharmacological Sciences 109 (suppl.2) 139-139, 2009.

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P1N-A9-6 The C terminus region of KCNE1 is essential for PKA-dependent functional regulation of the IKs channel

Junko Kurokawa, Asami Kaihara, Tetsushi Furukawa
Dept.Bio-informational Pharmacol., MRI, Tokyo Med.Dent.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 139-139, 2009.

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P1N-A9-7 L-type Cav1.2 calcium channel is initially expressed in a heart-restricted pattern within the early rat embryo

Sachiko Maeda, Takeshi Kobayashi, Nobutoshi Ichise, Takanori Kobayashi, Katsumasa Tanimoto, Kaori Shiratori, Noritsugu Tohse
Dept.Cellular Physiol.and Signal Transduction, Sapporo Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 139-139, 2009.

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P1N-A9-8 Effects of dronedarone on HERG and KCNQ1/KCNE1 channels

Ryoko Niwa, Atsuya Shimizu, Haruo Honjo, Kaichiro Kamiya
Res.Inst.of Environment.Med, Nagoya Univ
Journal of Pharmacological Sciences 109 (suppl.2) 139-139, 2009.

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P1M-A10-1 Vasodilating effect of cilostazol through inhibition of TRPC channels

Kinue Nishioka1, Marina Ariyoshi1, Ryuji Inoue2, Michio Nakaya1, Motohiro Nishida1, Hitoshi Kurose1
1Dept.Pharmacol Toxicol., Kyushu Univ.Sch.Pharmaceutical Sci., 2Dept.Physiol., Fukuoka Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 140-140, 2009.

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P1M-A10-2 Co-expression of the brain-specific short variant and the full-length of ryanodine receptor type 1 in cultured cells

Takahiro Hayashi1, Hideto Oyamada1, Toshiko Yamazawa2, Takashi Murayama3, Takashi Sakurai3, Masamitsu Iino2, Katsuji Oguchi1
1Dept.Pharmacol., Showa Univ.Sch.Med., 2Dept.Mol.Cell.Pharmacol., Univ of Tokyo., 3Dept.Pharmacol., Juntendo Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 140-140, 2009.

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P1M-A10-3 How does mercury inhibit water permeation of aquaporin-1?

Yoshinori Hirano1, 2, 3, Kenji Yasuoka2, Makoto Suematsu3, Masato Yasui1
1Dept.Pharmacol., Keio Univ.Sch.Med., 2Keio Univ., Sci.Tech., 3Dept.Biochem.and Integ
Journal of Pharmacological Sciences 109 (suppl.2) 140-140, 2009.

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P1M-A10-4 Improved enzymatic method for construction of genome-wide RNAi library

Isamu Taikou1, Kohtaroh Sugao1, Kenzo Hirose1, 2
1Dept.cell Physiol.Nagoya Univ.Grad.Sch.Med., 2Dept.Neurobiology., Grad.Sch.Med.Univ.Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 140-140, 2009.

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P1M-A10-5 Detection of action polymerization using split luciferase

Tetsuya Ishimoto1, 2, Hironori Izumi1, Takeaki Ozawa2, 3, Hisashi Mori1
1Dept.Mol.Neurosci., Grad.Sch.of Med.and Pharm.Sci., Univ.of Toyama, 2JST, PRESTO, 3Dept.Chem., Sch.Sci., Univ.of Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 141-141, 2009.

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P1M-A10-6 New fluoroprobes for high throughput assay for drugs acting on PKA

Yusuke Shibauchi, Hisanaka Ito, Yoshihisa Kudo
Tokyo Univ.of Pharm & Life Sci., Sch.Life Sci
Journal of Pharmacological Sciences 109 (suppl.2) 141-141, 2009.

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P1M-A11-1 Trigger activity of allergic reaction and effects of Fumaitang

Chen Qi, Chen Lan-ying
Jiangxi University of Traditional Chinese Medicine
Journal of Pharmacological Sciences 109 (suppl.2) 141-141, 2009.

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P1M-A11-2 Tumor-specificity, cytotoxicity and anti-inflammatory activity of Chinese herb extracts

Qing Chu1, Qin-Tao Wang1, Ken Hashimoto2, Kazue Satoh3, Hiroshi Sakagami2
1Dept.Periodont.Oral Med., The Fourth Military Med.Univ, 2Div.Pharmacol., Meikai Univ.Sch.Dent., 3Dep.Anatomy, Sch.Med., Show Univ
Journal of Pharmacological Sciences 109 (suppl.2) 141-141, 2009.

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P1M-A11-3 Isolation of a novel lectin from the globiferous pedicellariae of the sea urchin, Toxopneustes pileolus

Hideyuki Nakagawa1, Kozue Edo1, Hitomi Sakai1, Takuma Sugawaki1, Hiroshi Takae1, Mitsuko Shinohara2, Kiyoshi Ohura2, Haruhiko Sakuraba3
1Dept.of Life Sci., Univ.of Tokushima, 2Dept.of Pharmacol.Osaka Dental Univ., 3Dept.of Appl.Biol.Sci., Kagawa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 142-142, 2009.

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P1M-A11-4 Anti-inflammatory activity of alkaline extract of Sasa senanensis Rehder(SE)

Li Zhou1, Ken Hashimoto2, Madoka Kitajima3, Hiroshi Oizumi3, Takaaki Oizumi3, Kazue Satoh4, Hiroshi Sakagami2
1MPL, Meikai Univ.Sch.Dent., 2Div.Pharmacol., Meikai Univ.Sch.Dent., 3Daiwa Biol.Res.Inst.Co.Ltd., 4Dept.Anatomy, Sch.Med., Showa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 142-142, 2009.

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P1M-A11-5 Inhibition of TNF-α and IFN-γ-induced RANTES expression in HaCaT cell by naringin

Yun-xia Yang1, Liao Liu2, Jie Hao1
1Department of Pharmacology, West-China Medical Center, Sichuan University, 2Sichuan Maternity and Child Care Centers
Journal of Pharmacological Sciences 109 (suppl.2) 142-142, 2009.

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P1M-A11-6 An Atopic Dermatitis Model Established in NC Mice by Repeated Application of Dermatophagoides farinae

Yukiko Kawasaki1, Yasushi Hirasawa1, Shoko Otsu1, Takahiro Sugiura1, Tohru Toyoshi1, Masumi Yoshida1, Miho Iduhara2, Kohei Kyuki1
1Nihon Bioresearch Inc., 2Biostir Inc
Journal of Pharmacological Sciences 109 (suppl.2) 142-142, 2009.

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P1M-A11-7 Establishment of a simple novel pressure ulcer model in mice.-Study2-

Hiroshi Fujimura, Ikuo Takahashi, Nanako Imamura, Hiroshi Atai, Katsuhide Nishi
Pharmacology Division, Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 143-143, 2009.

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P1M-A11-8 Decrease in ceramide amounts in the stratum corneum of hairless mice with atopic dermatitis

Yoshitaka Miyamoto, Masanori Fujii, Hiroyuki Nakashima, Takeshi Nabe, Shigekatsu Kohno
Dept.Pharmacol., Kyoto Pharm.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 143-143, 2009.

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P1M-A12-1 Differential effects of P2X receptor antagonists on urodynamics and residual urine in rat frequent urination models

Masashi Iida, Akihito Iwami, Hiromi Katsura, Masahiro Ikeda, Katsuaki Ito
Dept.Vet.Pharmacol., Fac.Agri., Univ.Miyazaki
Journal of Pharmacological Sciences 109 (suppl.2) 143-143, 2009.

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P1M-A12-2 Involvement of P2X3 receptor in contractions of bladder smooth muscle induced by electrical field stimulation and α, β-methylene ATP

Hiromi Katsura, Masashi Iida, Masahiro Ikeda, Katsuaki Ito
Dept.Vet.Pharmacol., Fac.Agri., Univ.Miyazaki
Journal of Pharmacological Sciences 109 (suppl.2) 143-143, 2009.

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P1M-A12-3 The difference of ATP and α, β-methylene ATP responses in the afferent activity from urinary bladder and bladder pressure in anesthetized rats.

Takashi Okamura, Satoko Kimura, Hitoshi Kontani
Dept.Pharmacol., Fac.Pharm.Sci., Hokuriku Univ
Journal of Pharmacological Sciences 109 (suppl.2) 144-144, 2009.

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P1M-A12-4 Roles of proteinase-activated receptors in the increased detrusor muscle contractility and pollakisuria in cystitis in mice

Ken-ichiro Shiga, Mayumi Hirano, Katsuya Hirano
Div.Mol.Cardiol., Grad.Sch.Med.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 144-144, 2009.

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P1M-A12-5 Glucose-dependent enhancement of diabetic urinary bladder contraction is associated with a rho kinase-regulated protein kinase C pathway

Koji Nobe, Akiko Fujii, Taigi Yamazaki, Kazuo Honda
Dept.Pharmacol., Showa Univ.Sch.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 144-144, 2009.

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P1M-A12-6 N-Acylethanolamine-related enzymes expressed in human prostate cancer cells

Jun Wang1, 2, Li-Ying Zhao1, 3, Toru Uyama1, Kazuhito Tsuboi1, Natsuo Ueda1
1Dept.Biochem., Kagawa Univ.Sch.Med., 2Dept.Anesthesiol., 1st Affiliated Hosp., China Med.Univ., 3Dept.Stomatol.China Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 144-144, 2009.

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P1M-A12-7 Protective effect of edaravone, a radical scaveger, on ischemia-reperfusion injury in rat testis

Motoaki Saito, Tamamura Mayuko, Shogo Shimizu, Emi Kazuyama, Itaru Satoh, Yukako Kinoshita, Keisuke Satoh
Div.Mol.Phamacol., Tottori Univ.Fac.Med
Journal of Pharmacological Sciences 109 (suppl.2) 145-145, 2009.

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P1L-A13-1 Associations of salivary AQP5 and lipid rafts with salivary volume in men and women

Di Wang1, Ko Okamura2, Yasuko Ishikawa1
1Dept.Pharmacol., Tokushima Univ.Sch.Dent., 2Dept.of Legal Medicine, Osaka Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 145-145, 2009.

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P1L-A13-3 Endothelin-1 mediates proliferative response to cyclosporin A in cultured rat gingival fibroblasts

Nozomi Ohuchi1, Kazuhiko Hayashi2, Keishi Iwamoto3, Katsuo Koike3, Yasuo Kizawa4, Michiyoshi Nukaga1, Tomohito Kakegawa1, Hajime Murakami3
1Josai International Univ., 2Nihon Univ.Sch.Dent.at Matsudo, 3Toho Univ.Sch.Pharmaceut.Sci., 4Nihon Univ.Coll.of Pharmacy
Journal of Pharmacological Sciences 109 (suppl.2) 145-145, 2009.

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P1L-A13-4 Inhibition of Cyclooxygenase-1 directly down-regulates osteoclast activation

Akiko Karakawa1, Yukiko Fukawa2, Tsuneyoshi Sano3, Hitoshi Amano1, Shoji Yamada1
1Dept.Pharmacol., Showa Univ.Sch.Dent., 2Dept.Perio., Showa Univ.Sch.Dent., 3Dept.Anato., Showa Univ.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 145-145, 2009.

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P1L-A13-5 Metabolic acidosis promotes osteoclast differentiation in vitro

Kohtaro Kato, Ikuo Morita
Dept.Cell.Physiol.Chem., Tokyo Med.and Dent.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 146-146, 2009.

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P1L-A13-6 GABABR molecule modulates cellular maturation in osteoblasts

Yoshifumi Takahata, Takeshi Takarada, Kyosuke Uno, Sayumi Fujimori, Eiichi Hinoi, Yukio Yoneda
Lab.Mol.Pharmacol., Kanazawa Univ.Grad.Sch.Nat.Sci.Tech
Journal of Pharmacological Sciences 109 (suppl.2) 146-146, 2009.

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P1L-A13-7 Modulation of BMP-2-induced osteoblastic differentiation by PDZRN3 protein

Takeshi Honda, Hisato Yamamoto, Aiko Ishii, Makoto Inui
Dept.Pharmacol., Yamaguchi Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 146-146, 2009.

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P1L-A13-8 p70 S6 kinase negatively regulates FGF-2-stimulated IL-6 synthesis inosteoblasts:function at a point downstream from protein kinase C

Chiho Minamitani1, Seiji Adachi1, Rie Nishiwaki1, Haruhiko Tokuda3, Takanobu Otsuka2, Osamu Kozawa1
1Dept.Pharmacol.Gifu Univ.Graduate Sch.Med., 2Dept.Orthopedic Surg.Nagoya City Univ.Graduate Sch.Med., 3Dept.Clin.Labo.National Hospital Geria.Med
Journal of Pharmacological Sciences 109 (suppl.2) 146-146, 2009.

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P1L-A14-1 Microarray profiling identified a molecular signature associated with ritodrine-induced liver toxicity

Hiroyoshi Tsuchiya1, Hidetoshi Tsuda2, Akio Fujimura2, Taka-aki Koshimizu1
1Dep.Pharmacol., Div.mol.pharmacol., Jichi Med.Univ., 2Dep.Pharmacol., Div.clin.pharmacol., Jichi Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 147-147, 2009.

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P1L-A14-2 4-Oxononenal, but not 4-hydroxynonenal, converts xanthine dehydrogenase into oxidase in rat liver cytosol in vitro

Satoru Sakuma, Miki Negoro, Yohko Fujimoto
Dept.Physiol.Chem., Osaka Univ.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 147-147, 2009.

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P1L-A14-3 A simplified method to determine five cytochrome P450(CYP)probe drugs by HPLC in a single run

Liu Ying, Jiao Jian-Jie, Zhang Cai-Li, Lou Jian-Shi
Department of Pharmacology, Tianjin Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 147-147, 2009.

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P1L-A14-4 A HPLC method for the determination of vancomycin in human serum

Li Tian-Qi1, 2, Jiang De-Chun1, Wang YuQin1
1Department of Pharmacy, Xuanwu Hospital of Capital Medical University, 2School of Pharmaceutical Science of Peking University
Journal of Pharmacological Sciences 109 (suppl.2) 147-147, 2009.

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P1L-A14-5 Cisplatin-induced acute renal failure is accelerated in interleukin-6 knockout mice

Satoru Mitazaki1, Naho Kato2, Miwako Suto2, Kouichi Hiraiwa2, Sumiko Abe1
1Lab.Forensic Toxicol., Fac.Pharmacy, Takasaki University of Health and Welfare, 2Dept.Legal Med., Fukushima Med.University
Journal of Pharmacological Sciences 109 (suppl.2) 148-148, 2009.

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P1L-A14-6 Investigation of gene polymorphisms and personality traits in migraine by multivariate analysis

Yuika Naito1, Masakazu Ishii1, Yukiko Hosaka1, Yuko Naito1, Hideto Oyamada2, Atsuko Imagawa3, Johji Takahashi3, Kenji Shida4, Shunichi Shimizu1, Katsuji Oguchi2, Yutaka Masuda4, 5, Hajime Hara3, Shino Usami1, 2, 6, Yuji Kiuchi1
1Dept.Pathophysiol., Sch.Pharm.Sci., Showa Univ., 2Dept.Pharmacol., Sch.Medicine, Showa Univ., 3Dept.Neurol., Showa Univ.Fujigaoka Hospital, 4Dept.Anesthesiol., Sch.Medicine, Showa Univ., 5Dept.Res.Devel.for Innovative Medical Needs., Sch.Pharm.Sci., Showa Univ., 6Usami Neurosurgery Clinic/Institute
Journal of Pharmacological Sciences 109 (suppl.2) 148-148, 2009.

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P1L-A14-7 Association between gene polymorphisms and clinical response to triptans in migraine

Yuika Naito1, Masakazu Ishii1, Atsuko Imagawa2, Johji Takahashi2, Hajime Hara2, Shino Usami1, 3, 4, Yuji Kiuchi1
1Dept.Pathophysiol., Sch.Pharm.Sci., Showa Univ., 2Dept.Neurol., Showa Univ.Fujigaoka Hospital, 3Dept.Pharmacol., Sch.Medicine, Showa Univ., 4Usami Neurosurgery Clinic/Institute
Journal of Pharmacological Sciences 109 (suppl.2) 148-148, 2009.

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P1L-A14-8 Enhancement of quinone-induced hepatotoxicity by cytochrome P450 inhibition in rats

Yasuhiro Ishihara, Satomi Ishii, Yufu Sakai, Norio Shimamoto
Facul.Pharma.Sci.Kagawa Campus, Tokushima Bunri Univ
Journal of Pharmacological Sciences 109 (suppl.2) 148-148, 2009.

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P1L-A15-1 Effects of histamine H4 receptor antagonist JNJ7777120 on the incidence of scratching behavior in mice

Manabu Oda, Eriko Suwa, Tomonori Nakamura, Hiromi Sato, Katsunori Yamaura, Koichi Ueno
Dept.Geriatr.Pharmacol.Ther., Grad.Sch.of Pharm.Sci., Chiba Univ
Journal of Pharmacological Sciences 109 (suppl.2) 149-149, 2009.

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P1L-A15-2 Promotion of skin epithelial cell migration by a tetrapeptide derived from the C domain of IGF-1

Kenji Matsuura1, Toshikazu Gondo2, Teruo Nishida3, Makoto Inui1
1Dept.Pharmacol., Yamaguchi Univ.Grad.Sch.Med., 2Surg.Pathol., Yamaguchi Univ., 3Dept.Ophthalmol., Yamaguchi Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 149-149, 2009.

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P1L-A15-3 Effects of aqueous extract from lycopsis orientalis linn on algaesthesis and skin ulcer in mice

Zhang Hai-Gang, Sun Wen-Xiao
Dept.Pharm., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 149-149, 2009.

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P1L-A15-4 Effect of olanzapine on glucose transport system in 3T3-L1 adipocytes

Mako Toyoda, Atsushi Yamauchi, Kengo Nakagama, Keichi Fujimoto, Ei Sejima, Hideki Shuto, Yasufumi Kataoka
Dept.Pharm.Care.Health Sci., Fac.Pharm.Sci., Fukuoka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 149-149, 2009.

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P1L-A15-5 Development of a new experimental method for assessment of anti-obesity effect using forced Tred-mil exercise

Noriyuki Yamazaki, Masahiro Kishinami, Tohru Masuzawa
New Drug Development Research Center Inc
Journal of Pharmacological Sciences 109 (suppl.2) 150-150, 2009.

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P1L-A15-6 Strain differences in high fat diet-induced obesity and glucose intolerance in mice

Yukari Matsui1, 2, Yasushi Hirasawa1, Takahiro Sugiura1, Yukiko Kawasaki1, Tohru Toyoshi1, Mikio Ito2
1Nihon Bioresearch Inc., 2Lab.of Anal.Pharmacol., Grad.Sch.of Envirom.and Human Sci., Meijo Univ
Journal of Pharmacological Sciences 109 (suppl.2) 150-150, 2009.

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P1L-A15-7 Impact of plasma adiponectin on the stroke-onset in a rat spontaneous stroke model

Kana Ooshima1, Hiroshi Sakaue1, Masaki Tabuchi1, Yasumitsu Akahoshi2, Ashenagar Mohammad Said1, Atsuko Niwa1, Hideaki Higashino1
1Dept.Pharmacol.Kinki Univ.Sch.Med., 2Life Sci.Res.Inst.Kinki Univ
Journal of Pharmacological Sciences 109 (suppl.2) 150-150, 2009.

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P1L-A15-8 Non-invasive in vivo imaging of adipose tissue using bioluminescent imaging techniques

Hiroshi Fushiki1, Ryo Yoshimoto1, Akira Gomori1, Tewari Shruti2, Yoshihiro Hayakawa1, Satoshi Ozaki1, Hisashi Ohta1
1Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, 2Temple Univ, Coll Sci & Technol, Dept Biol, Life Sciences Building Temple University
Journal of Pharmacological Sciences 109 (suppl.2) 150-150, 2009.

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P1L-A16-1 Involvement of NADPH oxidase in cyclooxygenase-2 expression on gastric damage induced by ischemia/reperfusion in rats

Akari Nakagiri1, 2, Masaaki Sunamoto1, Motonobu Murakami1
1Dept.Pharmacotherapeutics, Doshisha Women's College, 2Div.Pathological Sci, Dept.Pharmacol
Journal of Pharmacological Sciences 109 (suppl.2) 151-151, 2009.

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P1L-A16-2 Effects of cyclooxygenase inhibitors on the docetaxel induced anorexia in rats

Keiko Asano, Kouichi Yamamoto, Keita Okamura, Atsushi Yamatodani
Department of Medical Physics and Engineering, Graduate School of Allied Health Sciences, Faculty of Medicine, Osaka University
Journal of Pharmacological Sciences 109 (suppl.2) 151-151, 2009.

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P1L-A16-3 Detrimental role of endothelial nitric oxide synthase(eNOS)in the increased ulcerogenic response to indomethacin in adjuvant-induced arthritic rats

Shinichi Kato, Fumikazu Ohkawa, Yasuyuki Itoh, Kikuko Amagase, Koji Takeuchi
Div.of Pathol.Sci., Dept.of Pharmacol.and Exp.Ther., Kyoto Pharm.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 151-151, 2009.

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P1L-A16-4 Allyl-isothiocyanate, a pungent ingredient of wasabi, induces gastric tight junction barrier dysfunction via TRPA1-independent pathway

Shogo Sato1, 2, Kimihito Tashima1, Kenjiro Matsumoto1, Toshihiko Murayama2, Syunji Horie1
1Lab.Pharmacol., Fac.Pharm.Sci., Josai International Univ., 2Lab.Chem.Pharmacol, Grad.Sch.Pharm.Sci.Chiba Univ
Journal of Pharmacological Sciences 109 (suppl.2) 151-151, 2009.

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P1L-A16-5 Effects of chemical entities on gastrointestinal motility in conscious dogs

Hiroizumi Yamanaka, Kazuaki Sasaki, Yasuo Nakamura, Seiichi Katayama, Masakazu Imaizumi, Hiroshi Atai, Katsuhide Nishi
Mitsubishi Chemical Safety Institute Ltd.Kumamoto Laboratory
Journal of Pharmacological Sciences 109 (suppl.2) 152-152, 2009.

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P1L-A16-6 Immunohistochemical co-localization of transient receptor potential vanilloid(TRPV)1 and sensory neuropeptides in mouse rectum

Kenjiro Matsumoto, Takuji Hosoya, Kimihito Tashima, Syunji Horie
Dept.Pharmacol., Fac.Pharm.Sci., Josai Int.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 152-152, 2009.

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P1L-A16-7 Proinflammatory cytokines down-regulate expression of heat shock protein 70 and exaggerate oxidative injury in colonic epithelial cells

Itaru Kanauchi, Atsushi Fukumoto, Shun Ohmori, Akinori Yanaka
Dept.of Clin.Pharmacol., Tokyo Univ.of Science Faculty od Pham.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 152-152, 2009.

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P1L-A16-8 Roles of M2 and M3 muscarinic receptors involved in the generation of peristaltic movements in mouse ileum

Yasuyuki Tanahashi1, 2, Naoko Waki3, Toshihiro Unno3, Hayato Matsuyama3, Masahisa Yamada4, Wess Jurgen5, Seiichi Komori3
1Dept.Patho.Vet.Sci., Gifu Univ.Unite Grad.Sch.Vet.Sci., 2JSPS Reseach Fellow, 3Lab.Pharmacol., Dept.Vet.Med., Gifu Univ., 4Yamada Research Unit, RIKEN Brain Science Institute, 5Lab Bioorganic Chem., NIH-NIDDK
Journal of Pharmacological Sciences 109 (suppl.2) 152-152, 2009.

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P1L-A17-1 Naofen, a novel WD-repeat protein, mediates the tumor necrosis factor-α induced apoptosis in HEK293 cells

Lei Huang1, Guo-Gang Feng1, Jun-Hua Fan1, 2, Jun An1, 3, Fumio Kondo1, Tatsuro Koide4, Naohisa Ishikawa1
1Dept.Pharmacol., Aichi.Med.Univ Sch.of Med., 2Dept.Gastroent Int Med., Med.Sch., Nagoya Univ., 3Dept.Gastroent Surg., Aichi.Med.Univ., 4Health Reserch Center, Aichi Gakuin Univ
Journal of Pharmacological Sciences 109 (suppl.2) 153-153, 2009.

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P1L-A17-2 Effect of ethanol-induced oxidant stress on Fas-mediated apoptosis pathway in SK-Hep1

Yoshiya Mochizuki, Mayumi Tsuji, Hideto Oyamada, Hitomi Hasegawa, Yuko Udaka, Katsuji Oguchi
Dept.Pharmacol., Showa Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 153-153, 2009.

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P1L-A17-3 Dysfunction of ubiquitin-proteasome system induces neuronal cell death through an activation of NADPH oxidase

Akiko Yamamuro, Takumi Iyama, Yasuhiro Yoshioka, Atsushi Kasai, Sadaaki Maeda
Dept.Pharmacotherap., Setsunan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 153-153, 2009.

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P1L-A17-4 Effects of the length of polyglutamine tracts on polyglutamine-induced ER stress and intracellular signaling in PC12 cells

Hitoshi Nakayama, Amany EI-FAKhrany, Zing Zhao, Minoru Isosaki, Hiroyasu Satoh, Masanori Yoshizumi
Dept.Pharmacol., Nara Med.Univ.School.Med
Journal of Pharmacological Sciences 109 (suppl.2) 153-153, 2009.

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P1L-A17-5 Possible involvement of mGluR1 in the neurodegeration induced by prion-like protein, Doppel

Takehiro Matsubara1, 4, Naohiro Yamaguchi1, Yuka Sudo1, 4, Suehiro Sakaguchi 2, Yuko Ando 3, 4, Noriyuki Nishida1, Yasuhito Uezono1, 4
1Dept.Mol.Microbiol.Immunol., Nagasaki Univ.Grad.Sch.Biomed.Sci., 2Tokushima Univ., Inst.Enz.Res., Div.Mol.NeuroBiol, 3Dept.Anesth.Nagasaki Univ.Grad.Sch.Biomed.Sci., 4Dept.Pharmacol.Nagasaki Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 154-154, 2009.

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P1L-A17-6 Nuclear localization of an NAD+-dependent histone deacetylase ctSIRT3 by oxidative stress

Takashi Hayashi1, 2, Shin Hisahara2, Shun Shimohama2, Yoshiyuki Horio1
1Dept.Pharmacol., Sapporo Med.Univ., 2Dept.Neurol., Sapporo Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 154-154, 2009.

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P1L-A17-7 Study on HepG-2 apoptosis induced by saponins isolated from asparagus and the effects on the activities of Caspase-8, 9, 3

Ji Chenfeng, He Xu, Ji Yu-Bin
Postdoctoral Research Station, Life Sciences and Environmental Sciences Research Center, Harbin University of Commerce
Journal of Pharmacological Sciences 109 (suppl.2) 154-154, 2009.

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P1L-A17-8 Effect of Juglone on Inducing Apoptosis and Morphological Changes of SGC-7901 Cells

Qu Zhong-Yuan, Zou Xiang, Ji Yu-Bin
Postdoctal Programme of Institute of Materia Medica of Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin University of Commerce
Journal of Pharmacological Sciences 109 (suppl.2) 154-154, 2009.

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P1O-P1-1 Trimethyltin inhibits induction of long-term potentiation prior to neuronal death in the dentate gyrus in mice

Yuka Yamagishi, Yasuko Sakata, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa Ito
Research Unit of Pharmacol., Dept.of Clinical Pharm., Coll.of Pharm., Nihon Univ
Journal of Pharmacological Sciences 109 (suppl.2) 155-155, 2009.

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P1O-P1-2 Aggressive behaviors induced by cerebral depletion of serotonin in rats and amelioration by yokukansan, a traditional Japanese medicine

Hitomi Kanno, Takuji Yamaguchi, Kyoji Sekiguchi, Kiyoshi Terawaki, Mitsutoshi Yuzurihara, Yasushi Ikarashi, Yoshio Kase
TSUMURA Research Laboratories
Journal of Pharmacological Sciences 109 (suppl.2) 155-155, 2009.

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P1O-P1-3 Effect of social isolation and re-socialization on expression levels of Early growth response(Egr)in the brain and latent learning in mice

Kazuya Ono, Yukihisa Murakami, Michihisa Tohda, Kinzo Matsumoto
Div.Medicinal Phamacol., Inst.Natural Med., Univ.Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 155-155, 2009.

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P1O-P1-4 Neuronal death in tamoxifen-driven conditional ADAR2 knockout mice

Daisuke Kimura1, 2, Takuto Hideyama2, Takeshi Suzuki1, Shin Kwak2
1Div Basic Biol, Fac Pharm, Keio Univ, 2Dept Neurology, Grad Schl Med, Univ Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 155-155, 2009.

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P1O-P1-5 Ameliorating effect of cloperastine on tricyclic antidepressant-resistant depression rats

Yukino Ogata, Kazuaki Kawaura, Sokichi Honda, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept.Environ.Mol.Health Sci., Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 156-156, 2009.

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P1O-P1-6 Diacylglycerol kinaseβ(DGKβ)knock out mice show mania-like behaviors

Kenichi Kakefuda1, Atsushi Oyagi1, Kazuhiro Tsuruma1, Masamitsu Shimazawa2, Koichi Yokota3, Yasuhito Shirai4, Kyoji Horie5, Naoaki Saito4, Junji Takeda5, Hideaki Hara1
1Dept.Biofunct.Eval., Mol.Pharmacol., Gifu Pharmaceut.Univ., 2Dept.Biofunct.Mol., Gifu Pharmaceut.Univ., 3Carna Biosciences, Inc., 4Biosignal Research Center, Kobe Univ., 5Dept.Soc and Envir.Med.Osaka Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 156-156, 2009.

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P1O-P1-7 Pharmacological evaluation of the hyperthermia-induced seizure in Scn1a mutant rats

Shizuka Ishihara1, Nobumasa Sofue1, Saki Shimizu1, Tomoji Mashimo2, Toshiko Tsurumi2, Tadao Serikawa2, Masashi Sasa3, Yukihiro Ohno1
1Lab.Pharmacol., Osaka Univ.Pharm.Sci., 2Inst.Lab.Animals, Grad.Sch.Med.Kyoto Univ., 3Nagisa Hospital
Journal of Pharmacological Sciences 109 (suppl.2) 156-156, 2009.

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P1O-P2-1 Receptor subtypes involved in dopaminergic modulation of"synchronized inhibition"in the rat amygdala

Hironori Ohshiro, Takayuki Murakoshi
Dept.Life Sci., Univ.Tokyo, Grad.Sch.Arts & Sci
Journal of Pharmacological Sciences 109 (suppl.2) 156-156, 2009.

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P1O-P2-2 Neuroprotective effects of Ginkgolide B against acute cerebral ischemia in rat

Thura Min1, Kazuya Hokamura2, Seiji Yamamoto3, Hiroko Koyama4, Hideki Ishii5, Masaaki Suzuki4, 5, Kazuo Umemura1
1Dept.Pharmacol., Hamamatsu Univ.Sch.Med., 2Mol.Imag.Front.Res.Cent., Hamamatsu Univ.Sch.Med., 3Photon Med.Res.Cent., Hamamatsu Univ.Sch.Med., 4Regeneration and Advanced Med.Sc.Gifu Univ.Graduate Sch.of Med., 5Riken Cent.of Mol.Imag.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 157-157, 2009.

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P1O-P2-3 Functional coupling of microsomal prostaglandin E synthase-1 and cyclooxygenase-2 in stroke-reperfusion injury

Yuri Hirayama1, Yuri Ikeda-Matsuo1, Satoshi Uematsu2, Shizuo Akira2, Yasuharu Sasaki1
1Lab.Pharmacol., Sch.Pharmac.Sci., Kitasato Univ., 2Dept.Host Defense, Res.Inst.Microbial Diseases, Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 157-157, 2009.

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P1O-P2-4 The de novo biosynthesis of lysophosphatidic acid(LPA), an initiator of neuropathic pain, following intense stimulation of primary afferent fiber

Makoto Inoue, Hiroshi Ueda
Mol.Pharmacol.& Neurosci., Nagasaki Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 157-157, 2009.

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P1O-P2-5 Anti-allodynia effects of platelet-activating factor(PAF)receptor antagonists on developing and established mechanical allodynia in neuropathic pain model

Tomoya Kitayama1, Naoyo Motoyama2, Katsuya Morita1, Hiroko Oka1, Fusanori Nishimura2, Toshihiro Dohi3, 4
1Dept.Dent.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci., 2Dept.Dent.Sci.Heal.Prom., Hiroshima Univ.Grad.Sch.Biomed.Sci., 3Prof.Emeritus, Hiroshima Univ., 4Yamaguchi Orthopedic Hospital
Journal of Pharmacological Sciences 109 (suppl.2) 157-157, 2009.

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P1O-P2-6 Analgesic effects of mexiletine, imipramine and gabapentin in various kinds' neuropathic pain model rats

Yuiichi Nishiyama, Ikuo Takahashi, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Mitsubishi Chemical Safety Institute Ltd.Kumamoto Laboratory
Journal of Pharmacological Sciences 109 (suppl.2) 158-158, 2009.

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P1O-P2-7 Hydrogen sulfide induces neuronal differentiation via sensitization of Cav3.2 T-type calcium channels followed by activation of Src family tyrosine kinase in NG108-15 cells

Takeshi Tarui1, Kazuki Fukami1, Keita Nagasawa1, Shigeru Yoshida2, Fumiko Sekiguchi1, Atsufumi Kawabata1
1Div.Pharmacol.Pathophysiol., Kinki Univ.Sch.Pharm., 2Dept.Life Sci., Kinki Univ.Sch.Sci.Engineer
Journal of Pharmacological Sciences 109 (suppl.2) 158-158, 2009.

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P1O-P2-8 Biotransformation of dl-PHPB, a novel anti-ischemic stroke pro-drug in vitro and in vivo

Li Jiang, Xu Shaofeng, Wang Ling, Feng Nan, Wang Xiaoliang
Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 158-158, 2009.

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P1O-P3-1 Regulation of Kv4.2 potassium channel by NMDA receptor activity

Mutsuo Nuriya1, Takashi Ito1, 2, Masato Yasui1
1Dept.Pharmacol., Keio Univ.Sch.Med., 2Dept.Pediatrics, Kitasato Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 158-158, 2009.

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P1O-P3-2 Functional impact of RIMs on gating of voltage-dependent Ca2+ channels

Yoshitsugu Uriu1, Minoru Wakamori2, Koji Yamazaki1, Miki Takafumi1, Shigeki Kiyonaka1, Emiko Mori1, Yasuo Mori1
1Dept.Synth.Chem.& Biol.Chem., Kyoto Univ., Katsura Campus, 2Dept.Oral Biol.Tohoku Univ
Journal of Pharmacological Sciences 109 (suppl.2) 159-159, 2009.

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P1O-P3-3 The effect of Methamphetamine(MAP)on GIRK channel expression in the brain

Sokichi Honda, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept.Envion.Mol.Health Sci.Grad.Sch.Pharm.Sci.Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 159-159, 2009.

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P1O-P3-4 Functional characterization of the Cl- Pump subunit 55 kDa Protein(CIP55)

Kaori Kitagawa, Zheng-Mei Xiong, Yasuhisa Nakayama, Naoki Hattori, Chiyoko Inagakii, Tomoyuki Nakamura
Dept.Pharmacol., Kansai Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 159-159, 2009.

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P1O-P3-5 Involvement of the activated microglia in the blood-brain barrier breakdown induced by lipopolysaccharide

Junichi Matsumoto1, Noriko Sumi1, Tsuyoshi Nishioku1, Shinya Dohgu1, Shinsuke Nakagawa3, Atsushi Yamauchi1, Hideki Shuto1, Masami Niwa2, Yasufumi Kataoka1
1Dept.Pharm.Care Health Sci.Fac.Pharm.Sci., Fukuoka Univ, 2Dept.Pharmacol.1, Nagasaki Univ.Grad.Sch.Biomed.Sci., 3PharmaCo-Cell Inc
Journal of Pharmacological Sciences 109 (suppl.2) 159-159, 2009.

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P1O-P3-6 Role of Sox2 in the generation of microtuble-associated protein 2-positive cells from microglia

Hideki Nonaka, Tetsuhiro Niidome, Takeshi Kihara, Hachiro Sugimoto
Dept.Neurosci.Drug Discov., Grad.Sch.Pharmaceut.Sci., Kyoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 160-160, 2009.

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P1O-P3-7 A role of glutamine transporter expressed by glial cells in glutamate neurotoxicity

Masato Ogura, Hideo Taniura, Noritaka Nakamichi, Yukio Yoneda
Lab.Mol.Pharmacol., Kanazawa Univ.Grad.Sch.Nat.Sci.Tech
Journal of Pharmacological Sciences 109 (suppl.2) 160-160, 2009.

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P1O-P3-8 Protections of baicalein on rat brain mitochondria against chronic cerebral hypoperfusion-induced oxidative damage

Du Guan-Hua, Wang Yue-Hua, He Xiao-Li
National Center for Pharmaceutical Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 160-160, 2009.

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P1O-P4-1 Nicotine stimulates the promoter activity of human dopamine transporter gene

Kazumi Ohyama1, Chiharu Sogawa2, Norio Sogawa2, Katsuya Morita3, Toshihiro Doi3, Shigeo Kitayama2
1RI Lab., Okayama Univ.Dent.Sch., 2Dept.Dent.Pharmacol., Okayama Univ.Grad.Sch.Med.Dent.Pharmac.Sci, 3Dept.Dent.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 160-160, 2009.

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P1O-P4-2 Emerging role of monocarboxylate transporters in the synaptic activity in the nucleus of the solitary tract

Masashi Nagase1, 2, Takeshi Suzuki2, Fusao Kato1
1Lab.Neurophysiol., Dept.Neurosci., Jikei Univ.Sch.Med., 2Div Basic Biol., Fac.Pharm., Keio Univ
Journal of Pharmacological Sciences 109 (suppl.2) 161-161, 2009.

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P1O-P4-3 Differential effects of fluvoxamine on evoked and spontaneous excitatory synaptic transmission in spinal superficial dorsal horn neurons of the adult mouse

Orie Tomoyose, Hideki Ono, Mitsuo Tanabe
Lab.CNS Pharmacol., Grad.Sch.Pharm.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 109 (suppl.2) 161-161, 2009.

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P1O-P4-4 Effects of mu and kappa opioid receptor agonists on excitatory synaptic transmission in second-order neurons of the nucleus tractus solitarius in guinea pig brainstem slices

Yoshiaki Ohi, Saori Tsunekawa, Akira Haji
Lab.Neuropharmacol., Aichi Gakuin Univ.Sch.Pharm
Journal of Pharmacological Sciences 109 (suppl.2) 161-161, 2009.

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P1O-P4-5 Effects of sigma receptor agonists on excitatory synaptic transmission in second-order neurons of the nucleus tractus solitarius in guinea pig brainstem slices

Saori Tsunekawa, Yoshiaki Ohi, Akira Haji
Lab.Neuropharmacol., Aichi Gakuin Univ.Sch.Pharm
Journal of Pharmacological Sciences 109 (suppl.2) 161-161, 2009.

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P1O-P4-6 Substrate-dependent internalization of the high-affinity choline transporter

Takashi Okuda1, Kaori Osawa1, Yuki Nomura1, Tatsuya Haga2, Hidemi Misawa1
1Dept.Pharmacol., Fac.Pharm., Keio Univ., 2Inst.Biomol., Fac.Sci., Gakushuin Univ
Journal of Pharmacological Sciences 109 (suppl.2) 162-162, 2009.

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P1O-P4-7 Effects of dopamine transporter expression on treatment of ACTH in rats

Sayaka Emoto1, Yoshihisa Kitamura2, Ikuko Miyazaki3, Kouhei Kitagawa2, Tomoko Nagamachi1, Maho Doi2, Yui Ishimaru2, Masato Asanuma3, Toshiaki Sendo1
1Dept.Clin.Pharm.Okayama Univ.Grad.Sch., 2Dept.Pharmaceut.and Heal.Sci.Okayama Univ.Grad.Sch., 3Dept.Brain Sci.Okayama Univ.Grad.Sch
Journal of Pharmacological Sciences 109 (suppl.2) 162-162, 2009.

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P1O-P4-8 Involvement of noradrenergic system in the regulation of clock gene Per1 expression in C6 glioma cells

Norimitsu Morioka1, Tatsuhiko Sugimoto1, Atsuko Inoue1, Toshihiro Dohi2, Yoshihiro Nakata1
1Dept.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci., 2Dept.Dent.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 162-162, 2009.

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P1O-P5-1 PTEN alteration in the development of experimental model of Alzheimer's disease in mice induced by AlCl3

Yu Chang-Xi, Xu Jian-Wen, Yang Jian, Xu Ying, Chen Chou
Dept.Pharmacol., Fujian Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 162-162, 2009.

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P1O-P5-2 Microglial transplantation in Alzheimer's disease model rats

Hironori Tatsuda1, Kazuyuki Takata1, Yoshihisa Kitamura1, Ikuo Tooyama2, Takashi Taniguchi1
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2Mol.Neurosci.Res.Ctr., Shiga Univ.Med.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 163-163, 2009.

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P1O-P5-3 Characterization of cognitive deficits of transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine

Akira Nagakura, Junko Yarimizu, Yoshitsugu Shitaka, Akira Miyake, Nobuya Matsuoka
Pharmacol.Res.Labs., Astellas Pharma Inc
Journal of Pharmacological Sciences 109 (suppl.2) 163-163, 2009.

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P1O-P5-4 Early detection of Alzheimer's disease at the mild cognitive impairment stage using[11C]BF-227 PET

Kentaro Sugi1, 3, Nobuyuki Okamura1, 3, Shozo Furumoto2, Motohisa Kato1, Masanori Mori1, 3, Manabu Tashiro2, Ren Iwata2, Yukitsuka Kudo3, Hiroyuki Arai1, 4, Kazuhiko Yanai1
1Dept.Pharmacol., Tohoku Univ.Sch.Med., 2CYRIC, Tohoku Univ, 3Innovation Biomed.Engineering Center, Tohoku Univ, 4Dept Geriat Gerontolo.IDAC, Tohoku Univ
Journal of Pharmacological Sciences 109 (suppl.2) 163-163, 2009.

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P1O-P5-5 Antidepressants increase BDNF in primary astrocytes

Tetsuro Ozawa, Kayoko Fujishita, Keisuke Shibata, Schuichi Koizumi
Dept.Pharmacol., Yamanashi Univ.Facult.Med
Journal of Pharmacological Sciences 109 (suppl.2) 163-163, 2009.

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P1O-P5-6 Chronic stress induce depressive behavior in ovariectomized mice

Atsushi Sato1, Osamu Nakagawasai1, Akira Oba1, Yuichiro Arai2, Satoru Mitazaki3, Hiroshi Onogi1, Kenji Wakui1, Fukie Niijima1, Koichi Tan-No1, Takeshi Tadano1
1Dept.Pharmacol., Tohoku Pharmaceu.Univ., 2Division of Pharmacol., Sch.of Pharmaceut.Sci., Ohu Univ., 3Lab.Foren.Toxicol., Facl.Pharmacy, Takasaki Univ.of Health and Welfare
Journal of Pharmacological Sciences 109 (suppl.2) 164-164, 2009.

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P1O-P5-7 Differences in the strain of the mouse in the antidepressant test

Takashi Tashiro, Hiroaki Fukuda, Namie Beppu, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Kumamoto Laboratory, Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 164-164, 2009.

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P1N-P7-1 Mitogen-activated protein kinases ERK 1/2-and p38-GATA-4 pathways mediate the Ang II-induced activation of FGF-2 gene in neonatal rat cardiomyocytes

Tang Wenjie, Liu Peiqing
Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University
Journal of Pharmacological Sciences 109 (suppl.2) 164-164, 2009.

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P1N-P7-2 Modified sympathetic nerve system activity with over-expression of the voltage-dependent calcium channel β3 subunit

Manabu Murakami, Takayoshi Ohba, Kyoichi Ono
Dept.Physiol., Akita Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 164-164, 2009.

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P1N-P7-3 Jab1, a novel human ETAR-interacting protein, regulates cell surface ETAR level and intracellular signaling by promoting ubiquitination and lysosomal degradation of ETAR

Arata Nishimoto, Lingyun Lu, Tadashi Nishiya, Takahiro Horinouchi, Soichi Miwa
Dept.Cellular Pharmacol., Hokkaido Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 165-165, 2009.

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P1N-P7-4 Methylgloxal enhances sodium nitroprusside-induced relaxation in isolated blood vessel

Masashi Mukohda, Hideyuki Yamawaki, Muneyoshi Okada, Yukio Hara
Lab.Vet.Pharmacol., Kitasato Univ.Sch.Vet.Med
Journal of Pharmacological Sciences 109 (suppl.2) 165-165, 2009.

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P1N-P7-5 Contribution of Na+/Ca2+ exchanger to development of pressure-induced myogenic constriction in rat posterior cerebral arteries

Toshihide Kashihara1, Koichi Nakayama2, Toshio Matsuda3, Akemichi Baba4, Tomohisa Ishikawa1
1Dept.Pharmacol., Grad.Sch.Pharmaceut.Sci., Univ.Shizuoka, 2Dept.Mol.Cell Pharmacol., Fac.Pharmaceut.Sci, Iwate Medical Univ., 3Lab.Medicinal Pharmacol, Grad.Sch.Pharmaceut.Sci., Osaka Univ., 4Lab.Mol.Neuropharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 165-165, 2009.

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P1N-P7-6 Vasoconstrictors-induced relaxation in basilar artery is mediated by EDHF

Budbazar Enkhjargal1, Michio Hashimoto1, Yasushi Sakai2, Osamu Shido1
1Dept.Environmental Physiol., Shimane Univ.Facult.Med., 2Dept.Physical Thera., Bunkyo Gakuin Univ., Facult.Health Sci.Technol
Journal of Pharmacological Sciences 109 (suppl.2) 165-165, 2009.

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P1N-P7-7 5-hydroxytryptamine released from vascular adrenergic nerves inhibits CGRP nerve function in mesenteric arteries

Hirohito Fujii1, Naoyuki Hara1, Yoshihisa Kitamura2, Hiromu Kawasaki1
1Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmc.Sci., Okayama Univ., 2Dept.Pharmc.Care Hlth.Sci., Grad.Sch.Med.Den.Pharmc.Sci., Okayama Univ
Journal of Pharmacological Sciences 109 (suppl.2) 166-166, 2009.

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P1N-P7-8 Role of β-adrenoceptor subtypes in regulation of retinal circulation in diabetic rats

Tomoyo Miwa, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
Dept.Mol.Pharmacol., Kitasato Univ.Sch.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 166-166, 2009.

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P1N-P8-1 Tissue-type plasminogen activator enhanced the permeability of blood brain barrier in ischemia

Yasuhiro Suzuki1, Nobuo Nagai2, Kasumi Yamakawa3, Junichi Kawakami3, Kazuo Umemura1
1Dept.Pharmacol., Hamamatsu Univ.Sch.Med., 2Dept.Physiol.Kinki Univ.Sch.Med., 3Dept.Hosp.Pharm., Hamamatsu Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 166-166, 2009.

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P1N-P8-2 Effect of ischemia-reperfusion on pericytes of retinal blood vessels

Maya Hoshino, Tutomu Nakahara, Kunio Ishii
Dept.Mol.Pharmacol., Kitasato Univ.Sch.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 166-166, 2009.

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P1N-P8-3 Maternal Endotoxemia Results in Increases in Blood Pressure and Body Weight in Rats

Wei Yan-Ling, Li Xiao-Hui
Dept.Pharm., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 167-167, 2009.

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P1N-P8-4 Yolk sac-derived progenitor cells form cell clusters for the capillary network organization

Satomi Urakabe1, Seiji Yamamoto1, Ken-ichi Takano1, Hiroki Yokoo1, Masashi Ikutani2, Yoshinori Nagai2, Kiyoshi Takatsu2, Yuichi Hattori1
1Dept.Mol.and Med.Pharmacol., Gradu.Sch.Med., Univ.of Toyama, 2Dept.of Immunobiol.and Pharmacol.Gent., Gradu.Sch.Med., Univ.of Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 167-167, 2009.

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P1N-P8-5 HMGB1-heparin complex-induced angiogenesis is inhibited by HRG

Hidenori Wake1, Shuji Mori2, Keyue Liu1, Hideo.K.Takahashi1, Masahiro Nishibori1
1Dept.Pharmacol., Okayama Univ.Sch.Med.Dent.& Pharm., 2Shujitsu Univ.Sch.Pharm
Journal of Pharmacological Sciences 109 (suppl.2) 167-167, 2009.

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P1N-P8-6 Effects and mechanism of vitexin on myocardial ischemia/reperfusion injury in rats in vitro

Dong Liu-Yi1, Shao Xu2, Chen Zhi-Wu1
1Department of Pharmacology, Anhui Medical University, 2Hefei Qinxing Medicine and technology Co.Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 167-167, 2009.

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P1N-P8-7 The effects of the extracts of Valeriana officinalis L.on cardiac arrhythmias

Li Wen
Dept.Pharmacol., Hubei University of Chinese Medicine
Journal of Pharmacological Sciences 109 (suppl.2) 168-168, 2009.

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P1N-P9-1 Role of L1462 in Nav1.5 channel DIII-S6 in voltage-dependent gating and antiarrhythmic block

Nao Katayama, Keiichi Konno, Atsushi Kawakubo, Naoki Ishimaru, Akihiko Sunami
Dept.Pharm.Sci., International Univ.Health Welfare
Journal of Pharmacological Sciences 109 (suppl.2) 168-168, 2009.

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P1N-P9-2 The effects of IKur block kinetics on prolongation of human action potential duration

Shingo Murakami1, 2, Kenji Tsujimae1, Yoshihisa Kurachi1, 2
1Dept.Pharmacol, Osaka Univ.Sch.Med., 2MEI center, Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 168-168, 2009.

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P1N-P9-3 Computer simulated molecular modeling and analysis of NCX1 intracellular loop lesion

Nobuo Homma
Dept.Pharmacol., Yamanashi Univ., Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 168-168, 2009.

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P1N-P9-4 Oxidative and inflammatory stresses differentially regulate urocortins in HL-1 cardiomyocytes

Keiichi Ikeda
Dept.Pharmacol., Jikei Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 169-169, 2009.

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P1N-P9-5 Involvement of humoral factor in the development of cardiomyocytes in adult sinoatrial node cells culture

Akino Usami1, Shigeki Kiuchi1, Tae Shimoyama2, Rie Ito1, Fuminori Otuka2, Shigeto Suzuki1, Takashi Uezono1, Junichi Kurihara1, Kageyoshi Ono1
1Dept.Pharmacol., Fac.Pharmaceut.Sci., Teikyo Univ., 2Dept.Mol.Environm.Hlth., Fac.Pharmaceut.Sci., Teikyo Univ
Journal of Pharmacological Sciences 109 (suppl.2) 169-169, 2009.

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P1N-P9-6 Effects of carvedilol and metoprolol on cardiac remodeling and survival of dilated cardiomyopathy mice with troponin mutation

Dong-Yun Zhan, Sachio Morimoto, Cheng-Kun Du, Yuanyuan Wang, Toshiyuki Sasaguri
Dept.Clin.Pharmacol., Kyushu Unive.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 169-169, 2009.

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P1N-P9-7 Involvement of epidermal growth factor receptor transactivation in PAR1-mediated hypertrophy in rat cardiomyocytes

Hitomi Otani1, Kei Yoshioka1, Kenzo Kawai2, Hiromasa Araki2, Tomoyuki Nakamura1
1Dept.Pharmacol., Kansai Medical Univ., 2Res.Dev.Center, Fuso Pharmaceu.Ind.Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 169-169, 2009.

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P1N-P9-8 Evodiamine inhibits right ventricular hypertrophy induced by monocrotaline in rats

Gao Yong-Shuang1, Sun An-Sheng1, 2, Liu Jie2
1Department of Pharmacology, Zunyi Medical College, 2the Key Laboratory of Basic Pharmacoligy of Guizhou, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 170-170, 2009.

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P1M-P10-1 Localization of calcium store related proteins in smooth muscle cells of rat colon

Hideyuki Tanaka1, Kazuhiro Kohama2
1Dept.Labo.Sci., Gunma Univ.Sch.Health Sci., 2Dept.Mol.and Cell.Pharmacol., Gunma Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 170-170, 2009.

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P1M-P10-2 Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells

Naotoshi Nakamura, Toshiko Yamazawa, Yohei Okubo, Masamitsu Iino
Dept.Pharmacol., Grad.Sch.Med., Univ of Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 170-170, 2009.

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P1M-P10-3 Suppression of EGFR phosphorylation by amlodipine, a Ca2+ channel blocker, in human epidermoid carcinoma A431 cells

Junko Yoshida1, Takaharu Ishibashi1, 2, Matomo Nishio1
1Dept.Pharmacol., Kanazawa Med.Univ., 2Pharmacol.Sch.Nurs., Kanazawa Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 170-170, 2009.

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P1M-P10-4 Effects of betaine on[Ca2+]i and potential of cell membrane in HepG2 tumor cells

Miao Yu1, 2, Ji Yu-Bin1, 2, Gao Shi-Yong1, 2, Yang Hong-Dan1, 2
1Postdoctoral Research Station, Institute of Matetia Medica, Life Sciences and Environmental Sciences Research Center, Harbin University of Commerce., 2MOE Engineering Research Center of Natural Anticancer Drugs, Harbin Commerce University
Journal of Pharmacological Sciences 109 (suppl.2) 171-171, 2009.

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P1M-P10-5 Inhibition by prostaglandin E2 of store-operated Ca2+ entry in UDP-stimulated murine J774 macrophage

Masaaki Ito, Isao Matsuoka
Lab.Pharmacol., Fact.Pharm, Takasaki Univ.Health and Welfare
Journal of Pharmacological Sciences 109 (suppl.2) 171-171, 2009.

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P1M-P10-6 Quantitative analysis of inositol 1, 4, 5-trisphospate dynamics in calcium oscillations with FRET based biosensors

Akihiko Tanimura, Takao Morita, Akihiro Nezu, Yosuke Tojyo
Dept.Pharmacol., School of Denstistry, Health Sciences Univ.Hokkaido
Journal of Pharmacological Sciences 109 (suppl.2) 171-171, 2009.

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P1M-P10-7 BCR-mediated and store-operated Ca2+ entry(B-SOC):novel Stim1-dependent non-capacitative Ca2+ entry

Takao Morita1, Akihiko Tanimura1, Yoshihiro Baba2, Tomohiro Kurosaki2, Yosuke Tojyo1
1Dept.Pharmacol., Sch.Dent., Health Sci.Univ.Hokkaido, 2Lab.for Lymphocyte Differentiation, RIKEN Research Center for Allergy and Immunology
Journal of Pharmacological Sciences 109 (suppl.2) 171-171, 2009.

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P1M-P10-8 Involvement of TRPV channels and protein kinase C in cell-swelling induced insulin secretion from mouse pancreatic β-cells

Isao Doutsu, Yukiko Kaneko, Tomohisa Ishikawa
Dept.Pharmacol., Grad.Sch.Pharmaceut Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 109 (suppl.2) 172-172, 2009.

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P1M-P11-1 A novel CpG ODN increase antitumor effect of radiotherapy related to NO secretion but not to T-cell or macrophages activation on human CHG-5 glioma xenografts's growth in nude mice

Zhou Hong1, Jiang Weiwei1, Yan Wei1, Zhou Weiying1, Li Bin1, Cen Yanyan1, Wu Chong1, Ding Guofu1, Pang Xueli2, Zheng Jiang3
1Department of Pharmacology, College of Pharmaceutical, 2Department of Tumor, Southwest Hospital, 3Medical Research Center, Southwest Hospital, Third Military Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 172-172, 2009.

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P1M-P11-2 A study on anti-gastric cancer effect and mechanism of acetylshikonin

Yun Zeng1, Gang Liu1, Liming Zhou2
1Institute of Materia Medica and Department of Pharmacology, North Sichuan Medical College, Institute of Materia Medica and Department of Pharmacology, North Sichuan Medical College, 2Department of Pharmacology, West China Medical Center of Preclinical and Forensic Medicine, Sichuan University
Journal of Pharmacological Sciences 109 (suppl.2) 172-172, 2009.

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P1M-P11-3 Correlation between the abundance of Helicobacter pylori-derived urease and expression levels of PAR1 or PAR2 in the gastric tissue isolated from gastric cancer patients

Fumiko Sekiguchi1, Kazuki Fukami1, Kaori Takaoka1, Kensaku Miyake2, Takatsugu Yamamoto2, Shogo Tanaka2, Kohichi Ohno2, Hiroyasu Ishikura3, Mitsuhide Naruse4, Atsufumi Kawabata1
1Div.Pharmacol.Pathophysiol., Kinki Univ.Sch.Pharm., 2Dept.Surg., Ishikiriseiki Hosp., 3Dept.Emerg.Clin.Care Med., Fac.Med., Fukuoka Univ., 4Nat.Hosp.Org.Kyoto Med.Cent
Journal of Pharmacological Sciences 109 (suppl.2) 172-172, 2009.

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P1M-P11-4 Quantum chemical characterization of different heterocycles on cytotoxic activity

Yoshihiro Uesawa1, Mariko Ishihara2, Kiminori Mohri1, Hiroshi Sakagami3
1Dept.Clin.Pharm., Meiji Pharm.Univ., 2Div.Basic Chem., Meikai Univ.Sch.Dent., 3Div.Pharmacol., Meikai Univ.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 173-173, 2009.

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P1M-P11-5 QSAR of molecular structure and cytotoxic activity of 1, 2, 3, 4-tetrahydr oisoquinolins by semi-empirical molecular orbital

Mariko Ishihara1, Hiroshi Sakagami2
1Div.Basic Chem., Meikai Univ.Sch.Dent., 2Div.Pharmacol., Meikai Univ.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 173-173, 2009.

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P1M-P11-6 Study on anti-hepatocarcinoma effects of methylacryloylshikonin in vitro and in vivo

Xiaowei Zheng, Ruiling He, Zhenjun Shao, Lihong Wan, Wenbi Xiong, Liming Zhou
West China Medical Center, Sichuan University
Journal of Pharmacological Sciences 109 (suppl.2) 173-173, 2009.

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P1M-P11-7 Further study on the involvement of oxalate in the oxaliplatin-induced peripheral neuropathy in rats

Takehiro Kawashiri1, Nobuaki Egashira1, 2, Mariko Sakurai1, Takahisa Yano2, Hiroaki Ikesue1, 2, Ryozo Oishi1, 2
1Grad.Sch.Pharm.Sci., Kyushu Univ., 3Dept.Pharmacy.Kyushu Univ.Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 173-173, 2009.

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P1M-P11-8 Effect of mexiletine on oxaliplatin-induced neuropathy in rats

Shingo Hirakawa1, Nobuaki Egashira1, 2, Takahisa Yano2, Takehiro Kawashiri1, Hiroaki Ikesue2, Ryozo Oishi1, 2
1Grad.Sch.Pharm.Sci., Kyushu Univ., 2Dept.Pharmacy, Kyusyu Univ.Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 174-174, 2009.

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P1M-P12-1 Measurements of cystometry in conscious and unrestricted benign prostatic hyperplasia(BPH)model rats

Ryoji Mizumachi, Takahiro Matsumoto, Hiroaki Fukuda, Hiroshi Atai, Katsuhide Nishi
Kumamoto Laboratory Mitsubishi Chemical Safety Institute, Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 174-174, 2009.

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P1M-P12-2 Effects of Soybean extraction on benign prostatic hyperplasia in rats

Yu Li-Mei1, 2, Fan Zhen-Hai1, 2, Wu Qin2
1Key Laboratory of Cell Engineering of Guizhou Province, 2Department of Pharmacology, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 174-174, 2009.

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P1M-P12-3 Comparison of the potentiating effects of distigmine(Dis)and bethanechol(Bet)on the guinea-pig urinary bladder contractile functions studied by cystometry method

Naoki Aikawa, Sarasa Sekiya, Yoshio Tanaka, Katsuo Koike
Dept.Chem.Pharmacol., Toho Univ.Sch.Pharmaceu.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 174-174, 2009.

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P1M-P12-4 Mechanisms of M2 or M3 muscarinic receptor-mediated contractions in bladder smooth muscle

Masayuki Yamamoto1, Toshimi Hayashi2, Hayato Matsuyama2, Masahisa Yamada3, Jurgen Wess4, Toshihiro Unno1, 2, Seiichi Komori1, 2
1Dept.Patho.Vet.Sci., United Grad.Sch.Vet.Sci., Gifu Univ., 2Lab.Pharmacol., Dept.Vet.Med., Gifu Univ., 3Yamada Res.Unit, Brain Sci.Inst., RIKEN, 4Lab.Bioorganic Chem., Natl.Inst.DDKD
Journal of Pharmacological Sciences 109 (suppl.2) 175-175, 2009.

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P1M-P12-5 Identification of potential therapeutic targets in hypertension-associated bladder dysfunction

Makoto Yono, Yasuhiro Yamamoto, Aya Imanishi, Atsushi Fukagawa, Masaki Yoshida
Dept.of Urol.. Faculty of Med.and Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 175-175, 2009.

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P1M-P12-6 Alternation of bladder receptors in the rat models with interstitial cystitis

Akira Yoshida, Yoshihiko Ito, Aiko Kageyama, Humitaka Mori, Shizuo Yamada
Dept.Pharmacokinet.and Pharmacodyn., Sch.Pharm.Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 109 (suppl.2) 175-175, 2009.

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P1M-P12-7 Alterations of micturition parameter and bladder muscarinic receptor in rat models of metabolic syndrome

Yoshihiko Ito, Yuki Ishida, Yosuke Matsunaga, Shizuo Yamada
Dept.of Pharmacokinet.and Pharmacodyn., Sch.Pharm.Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 109 (suppl.2) 175-175, 2009.

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P1M-P12-8 Measurement of voiding function in conscious freely-moving rats by radio telemetry and its application for assessing the efficacy of drugs

Yuki Ishida1, Kazumi Fushimi1, Yosuke Matsunaga1, Masahiko Ikeda2, Shizuo Yamada1
1Dept.Pharmacokinet.and Pharmacodyn., Sch.Pharm.Sci., Univ.Shizuoka, 2Coll.Environ.Disast.Res., Fuji Tokoha Univ
Journal of Pharmacological Sciences 109 (suppl.2) 176-176, 2009.

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P1L-P13-1 Establishment of osteoblastic MC3T3-E1 cells stably transfected with cystine/glutamate antiporter

Kyosuke Uno, Takeshi Takarada, Keita Hamamichi, Yukio Yoneda
Lab.Mol.Pharmacol., Kanazawa Univ.Grad.Sch.Nat.Sci.Tech
Journal of Pharmacological Sciences 109 (suppl.2) 176-176, 2009.

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P1L-P13-2 Expression patterns of mechanosensitive TRP genes in MC3T3-E1 cells

Takashi Yoshida1, Yuki Miyajima2, Minoru Wakamori1
1Div.Mol Pharmacol and Cell Biophys., Dept.Oral.Biol.Tohoku univ.Grad.Sch.Dent., 2Div.Orthodontics and Dentfacial Orthopedics, Tohoku Univ.Grad.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 176-176, 2009.

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P1L-P13-3 A novel potent TRPV4 associated protein participates in endochondral bone formation

Atsuko Mizuno1, Makoto Suzuki2, Junichi Taniguchi1, Taka-aki Koshimizu1
1Dept.Pharmacol.Jichi.Medical Univ., 2Edogawabashi Suzuki Clinic
Journal of Pharmacological Sciences 109 (suppl.2) 176-176, 2009.

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P1L-P13-4 Effects of nifedipine on calcium channels in gingival fibroblasts

Toshimi Hattori, Pao-Li Wang
Dept.Dent.Pharmacol., Matsumoto Dent.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 177-177, 2009.

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P1L-P13-5 Calculation of self-repair rate from backscattered electron images of the abnormal layer in rat hard tissue by etidronate or NaF dosage

Tsuneyoshi Sano1, Tomio Morohashi2, Hitoshi Amano2, Shoji Yamada2, Masanori Nakamura1
1Dept.Oral Anato., Showa Univ.Sch.Dent., 2Dept.Pharmacol., Showa Univ.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 177-177, 2009.

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P1L-P13-6 Regulation by glutamate of cell differentiation through modulation of intracellular glutathione contents in mesenchymal stem cells

Mika Iemata, Takeshi Takarada, Yukio Yoneda
Lab.Mol.Pharmacol., Kanazawa Univ.Grad.Sch.Nat.Sci.Tech
Journal of Pharmacological Sciences 109 (suppl.2) 177-177, 2009.

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P1L-P14-1 Cigarette smoke extract attenuates neural crest migration by down-regulation of R-spondin1 via aryl hydrocarbon receptor

Atsushi Sanbe, Reiko Mizutani, Noriko Miyauchi, Junji Yamauchi, Akito Tanoue
Dept.Pharmacol., NRICHD
Journal of Pharmacological Sciences 109 (suppl.2) 177-177, 2009.

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P1L-P14-2 Effects of local anesthetics on adrenal chromaffin cell

Kenzou Mizuma1, Eiichi Tachikawa2, Yukiko Kondo1, Yasuyuki Irie1, Shinpei Ootake1, Eiichi Taira1, Kenji Suzuki3
1Dept.Pharmacol., Iwate Med.Univ., Sch.Med., 2Dept.Molecul.and Cellu.Pharmacol., Iwate Med.Univ., Sch.Pharma., 3Dept.Anesthesiol., Iwate Med.Univ., Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 178-178, 2009.

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P1L-P14-3 Effect of Pesticides on soil microbial and enzyme activity

Li Xia1, Wang Lan2, Li Xiao-Hui1
1Dept Pharm., Third Mil.Med.Univ., 2Chengdu Inst.Bio., Chin.Acad.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 178-178, 2009.

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P1L-P14-4 Imidazole antifungals, but not triazole antifungals, increase membrane Zn2+ permeability in rat thymocytes

Yoshiro Okano1, Akio Kinasaki1, Shiro Ishida1, Yasuo Oyama2
1Fuct.Pharma.Sci., Tokushima Bunri Univ., 2Fact.Integ.Arts and Sci
Journal of Pharmacological Sciences 109 (suppl.2) 178-178, 2009.

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P1L-P14-5 Renal injury in SHRSP fed diet containing canola oil for 6 weeks compared with WKY rats

Yukiko Naito1, Shigehiro Tachibana1, Mari Okimoto1, Tomoko Nagata2, Mami Furuya3, Toru Fukumitsu1, Naoki Ohara1, 4
1Lab.Pharmacol., Hatano Research Institute, Food and Drug Safety Center, 2Lab.Pathol., Hatano Research Institute, Food and Drug Safety Center, 3Lab.Toxicol.II, Hatano Research Institute, Food and Drug Safety Center, 4Open Res.Center, Kinjo Gakuin Univ
Journal of Pharmacological Sciences 109 (suppl.2) 178-178, 2009.

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P1L-P14-6 Effect of CYP2C19 and CYP2C9 Genotype on Concentration Prediction of Valproate in Epileptic Patients

Jiang De-Chun, Bai Xiangrong, Zhang QingXia, Lu Wei, Wang YuQin, Li Lin
Dept.Pharmacy, Xuanwu Hospital of Capital Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 179-179, 2009.

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P1L-P14-7 Estimation of the influence of valproate, carbamazepine, phenobarbital and phenytoin on oral clearance of topiramate with NONMEM

Zeng Yan, Yang Yang, Wang YuQing
Depart.Pharm, Xuanwu Hospital of Capital Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 179-179, 2009.

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P1L-P15-1 The creation and phenotypic analysis of the limb girdle muscular dystrophy 2C model

Chikara Sakamoto1, Yasuhito Shimada1, 2, 3, Yuhei Nishimura1, 2, 3, Toshio Tanaka1, 2, 3
1Department of Pharmacogenomics, Mie Univ.Graduate School of Medicine, 2Department of Bioinformatics, Life Science Research Center, Mie Univ., 3Department of Medical Chemogenomics, Venture Bisiness Laboratory, Mie Univ
Journal of Pharmacological Sciences 109 (suppl.2) 179-179, 2009.

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P1L-P15-2 Changes in macrophage on aorta by the oxidative stress in spontaneously hypertensive hyperlipidemic rats

Yuri Tomita1, Shinichi Iwai1, Toshio Kumai2, Shigeko Oonuma3, Chika Kurahashi1, Asayo Tsuboi1, Akihiko Yura1, Jyunki Koike3, Shinichi Kobayashi2, Katsuji Oguchi1
1Dept.Pharmacol., Syowa Univ.Sch.Med., 2Dept.Pharmacol., St.Marianna Univ.Sch.Med., 3Dept.Diagnostic Pathol., St.Marianna Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 179-179, 2009.

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P1L-P15-3 Mechanism of the onset of diabetic nephropathy in type 2 diabetic db/db mice(2nd report)

Makoto Hosoyamada, Ami Shikuma, Satomi Umemura, Yuichi Takiue, Masaki Kimura, Toshiaki Shibasaki
Div.Pharmacotherapeutics, Keio Univ.Faculty of Pharmacy
Journal of Pharmacological Sciences 109 (suppl.2) 180-180, 2009.

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P1L-P15-4 PCP-Treated mice as animal model of ADHD

Shiho Narusawa, Akihiro Mouri, Kazuya Toriumi, Takenao Koseki, Yuki Aoyama, Natsumi Ikawa, Takayoshi Mamiya, Toshitaka Nabeshima
Dept.Chem.Pharmacol., Meijo Univ.Grad.Sch.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 180-180, 2009.

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P1L-P15-5 Phosphoproteome profiling of the SJLB mice and the APP mutation transgenic mice

Masaoki Takano1, Mieko Otani1, Takami Tomiyama2, Hiroshi Mori2, Taizo Taniguchi3, Keiichi Kadoyama3, Shogo Matsuyama3
1Dept.Lifesciences Pharmacy, School of Pharm.Sci., Kobe Gakuin Univ., 2Depart.Neurosci.Grad.Sch.Med., Osaka City Univ., 3Fac.Pharm.Sci., Himeji Dokkyo Univ
Journal of Pharmacological Sciences 109 (suppl.2) 180-180, 2009.

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P1L-P15-6 The Role of IL-1 in activated microglia-induced learning and memory deficits

Kingo Kanda1, Sachiko Tanaka1, Tomoya Nakamachi2, Seiji Shioda2, Satoshi Numazawa1, Takemi Yoshida1
1Dept.Biochem Toxicol., Showa Univ.Sch Pharmaceu.Sci., 2Dept.Anat., Showa Univ.Sch Med
Journal of Pharmacological Sciences 109 (suppl.2) 180-180, 2009.

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P1L-P15-7 Experimental diabetes enhances Ca2+ mobilization and glutamate exocytosis in cerebral synaptosomes from mice

Eiki Satoh, Ayako Takahashi
Res.Cent.Animal Hyg.Food Saf., Obihiro Univ.Agric.Vet.Med
Journal of Pharmacological Sciences 109 (suppl.2) 181-181, 2009.

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P1L-P16-1 Ghrelin stimulates gastric motility of the anesthetized guinea-pig

Tatsuro Nakamura1, Takenori Onaga2, Takio Kitazawa1
1Dept.Pharmacol., Sch.of Vet.Med.Rakuno Univ., 2Dept.Physiol-Nutr., Sch.of Vet.Med.Rakuno Univ
Journal of Pharmacological Sciences 109 (suppl.2) 181-181, 2009.

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P1L-P16-2 Sulforaphane protects gastric mucosa against oxidative stress by enhancing histamine-stimulated gastric acid secretion in vitro

Mayumi Kato, Tatsunori Akaogi, Atsushi Fukumoto, Akinori Yanaka
Dept.of Clin.Pharmacol., Tokyo Univ.of Science Faculty of Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 181-181, 2009.

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P1L-P16-3 Importance of muscarinic acetylcholine receptor subtype 4 in carbachol-induced gastric acid secretion in mice

Kohei Yamazaki1, Nobuaki Takahashi1, Takuya Endo1, Shusaku Hayashi1, Kikuko Amagase1, Minoru Matsui2, Susumu Okabe3, Koji Takeuchi1
1Div.of Pathol., Sci., Dept.of Pharmacol.and Exp.Ther., Kyoto Pharm.Univ., 2Faculty of Pharm., Chiba Inst.of Sci., 3Dept.of Pharmacol., Faculty of Pharm.Sci., Doshisha Women's Univ
Journal of Pharmacological Sciences 109 (suppl.2) 181-181, 2009.

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P1L-P16-4 Artichoke leaf extract prevents acute gastriris in rats

Kazuo Ishida1, Ryoji Kojima2, Yuka Tsuda3, Makoto Tsuboi3, Mikio Ito1, 2
1Lab.Anal.Pharmacol., Grad.Sch.Envirom.and Human.Sci., Meijo Univ, 2Lab.Anal.Pharmacol, Fac.Pharmac., Meijo Univ., 3Ichimaru Pharcos Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 182-182, 2009.

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P1L-P16-5 Effect of ramosetron on tachykinin NK2 receptor-triggered serotonin release from guinea-pig colon

Shu-ichi Kojima1, Masashi Ikeda2, Yuichiro Kamikawa1
1Dept.Pharmacol., Dokkyo Univ.Sch.Med., 2Inst.Med.Sci., Dokkyo Univ.Sch.Med., Institute for Medical Science, Dokkyo Medical University School of Medicine
Journal of Pharmacological Sciences 109 (suppl.2) 182-182, 2009.

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P1L-P16-6 Examination of availability of biomarkers in rat plasma of colitis models

Shinichi Ozato, Ikuo Takahashi, Miyuki Yamamoto, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Kumamoto Laboratory, Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 182-182, 2009.

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P1L-P16-7 Anti-diarrhea effects and mechanism of abstract from Lappula Echinata Gilib

Guo Xiu-Ying, Yu Yue, Yang Feng-Rui, Gao Jian-Hua, Meng Lin
Dept.Pharmacol.Tianjin Medical Univ
Journal of Pharmacological Sciences 109 (suppl.2) 182-182, 2009.

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P1L-P17-1 Role of Ca2+-permeable TRPM7 channel on cell death in rat cardiac myoblast cells

Haruo Takemura, Daisuke Takemura, Yoshiyuki Horio
Dept.Pharmacol., Sapporo Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 183-183, 2009.

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P1L-P17-2 Induction of mitochondrion-mediated apoptosis of SGC-7901 cells by juglone and Bcl-2/Bax expression

Zheng Hong-Quan, Ji Yu-Bin, Qu Zhong-Yuan, Zou Xiang
Postdoctal Programme of Institute of Materia Medica of Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin University of Commerce
Journal of Pharmacological Sciences 109 (suppl.2) 183-183, 2009.

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P1L-P17-3 Induction of apoptosis in HepG-2 cells by sulforaphane via mitochondrial pathway

Ji Yu-bin, Zou Xiang, Liu Yang
Postdoctal Programme of Institute of Materia Medica of Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin University of Commerce
Journal of Pharmacological Sciences 109 (suppl.2) 183-183, 2009.

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P1L-P17-4 Role of DNase γ in the cell death induction of human oral squamous cell carcinoma cell lines

Ken Hashimoto, Hiroshi Sakagami
Div.Pharmacol., Meikai Univ.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 183-183, 2009.

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P1L-P17-5 A new model of retinal photoreceptor cell degeneration induced by cobalt chloride

Masayuki Niwa1, Hitomi Aoki2, Osamu Kozawa3, Akira Hara4
1United Grad Sch.Drug Discov.Med Inf.Sci., 2Dept.Tissue&Organ Develop., 3Dept.Pharmacol., 4Dept.TumorPathol
Journal of Pharmacological Sciences 109 (suppl.2) 184-184, 2009.

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P1L-P17-6 Role of DNA double-strand breaks in neurogenesis

Masahiro Kawabata1, Tetuya Ogino2, Teruyuki Kawabata3
1Dept.Basic Med.Sci., Hyogo Univ., 2Dept.Pathol.Res., Okayama Univ.Grad.Sch.Med.Dent.Pharm., 3Dept.Med.Engineering, Okayama Univ.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 184-184, 2009.

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P1L-P17-7 Morroniside prevents peroxide-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells

Wang Wen, Li Lin, Ai Houxi, Sun Fangling
Department of Pharmacology, Xuan-Wu Hospital of Capital Medical University, Key Laboratory for Neurodegenerative Diseases of Ministry of Education
Journal of Pharmacological Sciences 109 (suppl.2) 184-184, 2009.

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P1L-P17-8 Cytotoxic effects of the extract from Agaricus blazei Murill on HL-60 cells

Satomi Mii1, Tadashi Yasuhara2, Atsuko Inoue1, Norimitsu Morioka1, Yuko Hirai3, Hidetoshi Tahara1, Hiroshi Tomoda2, Yoshihiro Nakata1
1Hiroshima Univ., Grad.Biomed.Sci., 2Kitasato Univ.Sch.Pharm., 3Radiation Effects Research Foundation
Journal of Pharmacological Sciences 109 (suppl.2) 184-184, 2009.

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P2O-A1-1 Effect of restraint stress in mice on the expression levels of Npas4 and Nurr1 mRNA in the dentate gyrus of the hippocampus

Hiroyuki Koike1, 2, Jaesuk Yun2, Daisuke Ibi2, Atumi Nitta2, Yukio Yoneda1, Kiyofumi Yamada2
1Lab.Mol.Pharmacol., Kanazawa Univ.Grad.Sch.Nat.Sci.Tech., 2Dept.Neuropsychopharmacol.& Hosp Pharm., Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 185-185, 2009.

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P2O-A1-2 Inhibiting of dopamine reuptake improves short-term memory deficit induced by domoic acid, an amnesic shellfish poison, in mice

Ken-ichi Ueno, Satoshi Hashimoto, Kenichi Takahashi
Dept.Biol.Sci., Hokkaido Inst.Public Health
Journal of Pharmacological Sciences 109 (suppl.2) 185-185, 2009.

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P2O-A1-3 Enhanced formation of 4-hydroxynonenal-adducted proteins under neuroregeneration after neurodegeneration in the hippocampal dentate gyrus

Shohei Sano, Keiko Shimizu, Reiko Nagashima, Kiyokazu Ogita
Dept.Pharmacol., Setsunan Univ., Faclt.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 185-185, 2009.

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P2O-A1-4 Oral administration of the flavonoid fisetin specifically facilitates the induction of long-term potentiation in the hippocampal CA1 region of anesthetized rats

Kazuho Abe, Wenbin He, Tatsuhiro Akaishi
Lab.Pharmacol., Fac.Pharmacy, Musashino Univ
Journal of Pharmacological Sciences 109 (suppl.2) 185-185, 2009.

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P2O-A1-5 CNB-001, a synthesized pyrazole derivative of curcumin, promotes the induction of hippocampal long-term potentiation and the phosphorylation of Ca2+/calmodulin dependent protein kinase II

Tatsuhiro Akaishi1, Pamela Maher2, David Schubert2, Kazuho Abe1
1Lab.Pharmacol., Fac.Pharm., Musashino Univ., 2Cell.Neurobiol.Lab., Salk Inst
Journal of Pharmacological Sciences 109 (suppl.2) 186-186, 2009.

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P2O-A1-6 Transient spine dynamics in Arc-expressing neurons after exploratory experience

Takuma Kitanishi, Maki K.Yamada, Yuji Ikegaya, Norio Matsuki
Lab.Chem.Pharmacol., Grad.Sch.Pharm.Sci., Univ.Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 186-186, 2009.

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P2O-A1-7 Cognitive function of diabetic rats in relation with hippocampal IDE activity

Shozo Kito1, Shihomi Hidaka2, Akiko S.Shingo2
1Junshinkai-Kousei Rehabilitation Hospital, 2Hyogo Univ Sho of Health Sci
Journal of Pharmacological Sciences 109 (suppl.2) 186-186, 2009.

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P2O-A1-8 Supraspinally administered gabapentin depressed C-fiber-evoked field potentials(FPs)in rat spinal dorsal horn after induction of long-term potentiation(LTP)

Eri Miyasaka, Shohei Yamamoto, Hideki Ono, Mitsuo Tanabe
Lab.CNS Pharmacol., Grad.Sch.Pharm.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 109 (suppl.2) 186-186, 2009.

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P2O-A2-1 The involvement of AIF in motor neuron degeneration in a mouse model of ALS

Hirotaka Tanaka1, Hiroki Shimazaki1, Kazuhiro Tsuruma1, Masamitsu Shimazawa2, Hideaki Hara1
1Dept.Biofunct.Eval., Mol.Pharmacol., Gifu Pharmaceut.Univ., 2Dept.Biofunct.Mol., Gifu Pharmaceut.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 187-187, 2009.

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P2O-A2-2 Effects of JP-1302, a selective α2C adrenoceptor antagonist, on haloperidol-induced extrapyramidal motor disorders

Junta Imaki, Saki Shimizu, Yoshiko Kawai, Yukihiro Ohno
Lab.Pharmacol., Osaka Univ.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 187-187, 2009.

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P2O-A2-3 Effects of protein synthesis inhibitors on the behavioral sensitization induced by a single morphine exposure in mice

Luo Juan, Liang Jian-Hui
Natl.Institute on Drug Dependence, Peking Univ
Journal of Pharmacological Sciences 109 (suppl.2) 187-187, 2009.

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P2O-A2-4 Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states

Yukie Kawahara1, 2, 3, Hiroshi Kawhara2, Fumi Kaneko1, Makiko Yamada1, Yoshihiro Nishi3, Eiichiro Tanaka3, Akinori Nishi1
1Dept.Pharmacol., Kurume Univ.Sch.Med., 2Dept.Dental Anes., Kyushu Dental Colledge, Department of Dental Anesthesiology, Kyushu Dental College, 3Dept.Physiol., Kurume Univ.Sch.Med., Department of Physiology, Kurume University School of Medicine
Journal of Pharmacological Sciences 109 (suppl.2) 187-187, 2009.

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P2O-A2-5 Behavioral Pharmacology of plant-derived substances(20):Behavioral effects of linalool in mice.Comparison with diazepam

Toyoshi Umezu
Dev.Environm.Chem., Natl.Inst.Environm.Studies
Journal of Pharmacological Sciences 109 (suppl.2) 188-188, 2009.

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P2O-A2-6 Effect of restraint-stress on locomotor activity and body weight in histamine receptor gene deficient mice

Ayako Oikawa, Eiko Sakurai, Naoko Takino, Toshie Izutsu, Kazuhiko Yanai
Dept.Pharmacol., Tohoku Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 188-188, 2009.

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P2O-A2-7 Involvement of the α1 receptor in anti-immobility effects of the selective serotonin reuptake inhibitor(SSRI)paroxetine in the forced swimming test

Jun Yamada1, Yumi Sugimoto1, Masami Yamamoto2, Noriko Tagawa3, Yoshiharu Kobayahsi3, Yoshihiro Hotta4
1Dept.Pharmacol., Yokohama Coll.Pharm., 2Dept.Pharmacol., Kobe Pharm.Univ., 3Dept.Biomed.Chem., Kobe Pharm.Univ., 4Coll.Pharm., Kinjo Gakuin Univ
Journal of Pharmacological Sciences 109 (suppl.2) 188-188, 2009.

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P2O-A2-8 Strain differences of mice in immobility time in the forced swimming test and the seotonin 1A receptor bindings in brain

Yumi Sugimoto1, Sachiko Furutani2, Kazufumi Hirano3, Shizuo Yamada3, Yoshihiro Hotta4, Jun Yamada1
1Dept.Pharmacol., Yokohama Coll.Pharm., 2Dept.Pharmacol., Kobe Pharm.Univ., 3Dept.Biopharm.Sci., Sch.Pharm.Sci., Univ.Shizuoka, 4Dept.Biomed.Chem., Kobe Pharm.Univ., 5Coll.Pharm., Kinjo Gakuin Univ
Journal of Pharmacological Sciences 109 (suppl.2) 188-188, 2009.

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P2O-A3-1 Macroautophagy plays an important role in the degradation of mutant protein kinase C gamma found in spinocerebellar ataxia type 14

Kazuhiro Yamamoto1, Takahiro Seki1, Naoaki Saito2, Noboru Mizushima3, Norio Sakai1
1Dept Mol Pharmacol Neurosci, Grad Sch Biomed Sci, Hiroshima Univ, 2Lab Mol Pharmacl, Biosig Res Ctr, Kobe Univ, 3Dept Physiol Cell Biol, Grad Sch Facul Med, Tokyo Med Dent Univ
Journal of Pharmacological Sciences 109 (suppl.2) 189-189, 2009.

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P2O-A3-2 Antinociceptive properties of clerodendron bungei steud roots n-butyl alcohol extract in mice

Liu Jianxin, Lian Qi-shen
Departmcent of Pharmmacology, Gannan Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 189-189, 2009.

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P2O-A3-3 Characterization of H2S-induced neuronal death in cultured cortical neurons:involvement of the MEK/ERK pathway

Yuko Kurokawa1, Satoko Kubo1, Yoshiko Yamasaki1, Fumiko Sekiguchi1, Yukari Okamoto1, Yuma Maeda1, Toshiaki Kume2, Nobuyuki Fukushima3, Akinori Akaike2, Atsuhumi Kawadata1
1Div.Pharmacol.Pathophysiol., Kinki Univ.Sch.Pharm., 2Dept.Pharmacol., Grad.Sch.Pharmaceut.Sci., Kyoto Univ., 3Div.Molec.Neurobiol.Dept.Life Sci., Sch.Sci.Engineer.Kinki Univ
Journal of Pharmacological Sciences 109 (suppl.2) 189-189, 2009.

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P2O-A3-4 PKA-dependent inhibition of GABAergic synaptic transmission by gabapentin in locus coeruleus neurons in neuropathic conditions and its behavioral evidence

Keiko Takasu, Yu Kinoshita, Hideki Ono, Mitsuo Tanabe
Lab.CNS Pharmacol., Grad.Sch.Pharm.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 109 (suppl.2) 189-189, 2009.

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P2O-A3-5 Characterization of mechanisms of analgesics using chemically-induced allodynia models in mice

Mina Tsukamoto, Tetsuo Kiso, Toshiaki Aoki, Nobuya Matsuoka
Department of Neuroscience, Pharmacology Research Labs., Astellas Pharma Inc
Journal of Pharmacological Sciences 109 (suppl.2) 190-190, 2009.

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P2O-A3-6 Potent analgesic effects of buprenorphine in a rat neuropathic pain model

Tomoko Takahashi1, Hiroyuki Nishikawa2, Motohide Takemura3, Atsufumi Kawabata1
1Div.Pharmacol.Pathophysiol., Kinki Univ.Sch.Pharm., 2Res.Dev.Cent.Fuso Pharmaceut.Ind.Ltd., 3Dept.Oral Anat.Neurobiol., Osaka Univ.Grad.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 190-190, 2009.

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P2O-A3-7 Analgesic effect of Bushimatsu on neuropathic pain

Keisuke Shibata1, Takeshi Sugawara2, Kayoko Fujishita1, Tetsuro Ozawa1, Takashi Matsukawa2, Tsutomu Suzuki3, Schuichi Koizumi1
1Dept.Pharmacol., Yamanashi Univ.Facult.Med., 2Dept.Anesthesiol., Yamanashi Univ.Facult.Med., 3Dept.Toxicol., Hoshi Univ.Sch Pharm.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 190-190, 2009.

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P2O-A3-8 A critical role for Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide in the maintenance of neuropathic pain

Tomoko Takahashi1, Kenji Mitani1, Motohide Takemura2, Fumiko Sekiguchi1, Atsufumi Kawabata1
1Div.Pharmacol.Pathophysiol., Kinki Univ.Sch.Pharm., 2Dept.Oral Anat.Neurobiol., Osaka Univ.Grad.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 190-190, 2009.

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P2O-A4-1 Phosphorylation of ERK was decreased by chronic hyperglycemia in human neutoblastoma cells and mouse hippocampus

Kawashima Yuuki, Yasuhiro Kosuge, Yuka Yamaoka, Kumiko Ishige, Yuka Yamagishi, Yoshihisa Ito
Research Unit of Phamacol., Dept.of Clinical Pharm., Coll.of Pharm., Nihon Univ
Journal of Pharmacological Sciences 109 (suppl.2) 191-191, 2009.

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P2O-A4-2 FK1706, a novel non-immunosuppressive neurophilin ligand, modifies the course of painful diabetic neuropathy

Nobuhito Murai, Shunji Yamazaki, Takayuki Yamaji, Hiroko Yamamoto, Raymond D.Price, Nobuya Matsuoka, Seitaro Mutoh
Pharmacol.Res.Labs., Astellas Pharma Inc
Journal of Pharmacological Sciences 109 (suppl.2) 191-191, 2009.

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P2O-A4-3 Change of calbindin fibers between day and night in Otsuka Long Evans Tokushima Fatty rats

Takao Shimazoe1, Tomoko Okada1, Yoko Nawata2
1Dept.Pharmacoepidemiol., Grad.Sch.of Kyushu Univ., 2Dept.Pharmacol., Pharmaceut.Sci., Nagasaki Intl.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 191-191, 2009.

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P2O-A4-4 Accelerated expression and cytoplasmic translocation of HMGB1 after transient focal ischemia in diabetic rat brain

Naohiro Iwata, Mari Okazaki, Chisato Kasahara, Shinya Kamiuchi, Yasuhide Hibino
Immunobiochem.Grad.Sch.Pharm.Sci., Josai Univ
Journal of Pharmacological Sciences 109 (suppl.2) 191-191, 2009.

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P2O-A4-5 Rosiglitazone prevents oxidative/nitrative stress, gliosis and memory deficits induced by intracerebroventricular injection of streptozotocin in rats

Ouyang Changhan, Wu Jiliang
Dept.Pharmacol., Xianning College
Journal of Pharmacological Sciences 109 (suppl.2) 192-192, 2009.

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P2O-A4-6 Developmental exposure to pentachlorophenol affects the expression of thyroid hormone receptor β1 and synapsin I in rats cerebral cortex

Maiko Kawaguchi1, Kaori Morohoshi2, 3, Erina Saita4, 5, Rie Yanagisawa2, Gen Watanabe4, 5, Hirohisa Takano2, Masatoshi Morita6, 7, Hideki Imai8, Kazuyoshi Taya4, 5, Toshiyuki Himi1
1Lab.Toxicol.Pharmacol., Fac.Pharmacy, Musashino Univ., 2Biol.Risk Assess.Sec., National Inst.Environ.Stud., 3Mitsubishi Chem.Safety Inst.LTD.Yokohama Lab., 4Lab.Vet.Physiol., Dep.Vet.Med., Fac.Agri., Tokyo Univ.Agri.& Tec., 5Dep.Basic Vet.Sci., Unit.Grad.Sch.Vet.Sci., Gifu Univ., 6Res.Cent.Environ.Risk, National Inst.Environ.Stud., 7Dep.Biores., Fac.Agri., Ehime Univ., 8Div.Environ.Health Sci., Dep.Soc.Med., Fac.Med., Univ.Miyazaki
Journal of Pharmacological Sciences 109 (suppl.2) 192-192, 2009.

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P2O-A4-7 Establishment of the risk assessment system for the brain at an early postnatal stage

Kaoru Sato1, Yoshihiko Saitoh1, 2, Jun-Ichiro Oka2, James.E.Goldman3, Ken Nakazawa1
1Div.Pharmacol., NIHS, 2Lab.Pharmacol., Fac.Pharmaceut.Sci., Tokyo Univ.Sci., 3Dep.Pathol., Columbia Univ
Journal of Pharmacological Sciences 109 (suppl.2) 192-192, 2009.

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P2O-A5-1 D2/D3 agonist protects nigral dopaminergic neurons in oral-administration of rotenone-induced Parkinsonian mice

Mari Abe1, Yoshihisa Kitamura1, Masatoshi Inden1, 2, Kazuyuki Takata1, Takashi Taniguchi1
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2College of Pharm.Sci., Ritsumeikan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 192-192, 2009.

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P2O-A5-2 Distribution of Neuron/Glial2 positive microglia and its alteration in 6-hydroxydopamine-treated hemiparkinsonian rat brain

Masatoshi Inden1, 2, Yoshihisa Kitamura1, Kazuyuki Takata1, Takashi Taniguchi1
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2College of Pharm.Sci., Ritsumeikan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 193-193, 2009.

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P2O-A5-3 Study on serum level, PBMC mRNA expression of IL-1β, TNF-α, IL-6 in first-episode schizophrenia

Song Xue-Qin, LV Lu-Xian, Li Wen-Qian
Depart.Psychology, First Affiliated Hospital of Zhengzhou University
Journal of Pharmacological Sciences 109 (suppl.2) 193-193, 2009.

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P2O-A5-4 Evaluation of schizophrenia-like models induced by N-methyl-D-asparate(NMDA)receptor antagonist

Hiroaki Fukuda, Takashi Tashiro, Ikuo Takahashi, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Kumamoto Laboratory Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 193-193, 2009.

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P2O-A5-5 Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression

Saki Shimizu, Junta Imaki, Yoshiko Kawai, Yukihiro Ohno
Lab.Pharmacol., Osaka Univ.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 193-193, 2009.

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P2O-A5-6 Representation of fear memory acquisition by neuronal population in the lateral amygdala

Koichi Hashikawa, Hiroshi Nomura, Norio Matsuki
Lab.of Chem.Pharmacol., Grad.Sch.Pharm., Univ.of Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 194-194, 2009.

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P2O-A5-7 Anticonvulsant property of indazole

Nobuko Matsumura, Kazue Kikuchi-Utsumi, Koji Aoyama, Toshio Nakaki
Dept.Pharmacol., Teikyo Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 194-194, 2009.

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P2O-A6-1 Experimental study on effect and mechanism of COTT in regulating lipid metabolism

Sun Weidong, Liu Hui, Yun Sun
Dept.Clinical.Med.School of Med.Yangzhou Univ
Journal of Pharmacological Sciences 109 (suppl.2) 194-194, 2009.

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P2O-A6-2 The ingredient extracted from sunset abelmoschus flower has curative effect on non-alcoholic fatty liver disease in rat

ZhengMing Huang, KeZhang Hu, Kun Yang, WenBin Cao, GuoXia Nian, ShuTao He
Hospital 302 of PLA
Journal of Pharmacological Sciences 109 (suppl.2) 194-194, 2009.

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P2O-A6-3 Study on the correlated bionomics of the Lactobacillus acidophilus with cholesterol-degrading activity

Guicheng Dong, Shaoying Li, Jing Wang, Zhonghua Meng, Chenghui Liu
Faculity Food Science and Engineering, of Inner Mongolia Agriculture University, Science Road, Qingshan Community
Journal of Pharmacological Sciences 109 (suppl.2) 195-195, 2009.

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P2O-A6-4 Effects of Yokukansan on the impairments of spatial memory and BPSD-like behavior by repeated cerebral ischemia in rats

Ai Nogami1, 2, Kotaro Takasaki1, Katsunori Iwasaki1, Hirofumi Oishi1, Naoki Uchida2, Shutaro Katsurabayashi1, Kenichi Mishima1, Ryoihci Nishimura2, Michihiro Fujiwara1
1Dept.Neuropharmacology., Fukuoka Univ.Sch.Pharm.Sci., 2Dept.Psychiatry., Fukuoka Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 195-195, 2009.

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P2O-A6-5 Protective effects of Dendrobium Nobile Lindl.alkaloids in enrich-diet and streptozotocin induced diabetes rats

Huang Qi, Wu Qin, Yu Limei, Shi Jingshan
Department of Pharmacology, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 195-195, 2009.

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P2O-A6-6 Effects of Grain of paradise extracts on the sympathetic nerve activity and uncoupling protein expression in brown adipose tissue

Yasutake Shimizu1, Momoe Iwami1, Fatma Mahmoud1, Isao Suzuki2, Takahiko Shiina1
1Dept.Vet.Physiol., Gifu Univ., 2Dept.Environ.Symbio.Sci., Pref.Univ.Kumamoto
Journal of Pharmacological Sciences 109 (suppl.2) 195-195, 2009.

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P2O-A6-7 Activation mechanism of macrophages by lignin fractions

Hiroshi Sakagami1, Li Zhou2, Ken Hashimoto1, Hideo Hasegawa1, Kazue Satoh3, Madoka Kitajima4, Hiroshi Oizumi4, Takaaki Oizumi4, Yuichi Maeda5, Kenji Osawa5, Masaji Yamamoto6, Katsuaki Utsumi6
1Div.Pharmacol, Meikai Univ.Sch.Dent., 2MPL, Meikai Univ.Sch.Dent., 3Dept.Anatomy, Sch.Med., Showa Univ., 4Daiwa Biol.Res.Inst.Co., Ltd., 5Lotte Central Laboratory Co., Ltd., 6Maruzen Pharmaceutical Co.Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 196-196, 2009.

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P2N-A7-1 Nicorandil induce cyclooxygenase-2(COX-2)not only in the heart but also in the kidney

Kenichi Serizawa, Kenji Yogo, Hirokazu Sudo, Nobuhiko Ishizuka
Product Res.Lab.Chugai Pharmaceutical Co.Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 196-196, 2009.

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P2N-A7-2 Reduced NO production rapidly aggravates renal function through the activation of ET-1/ETA receptor pathway in DOCA-salt-induced hypertensive rats

Kimihiro Kimura, Mamoru Ohkita, Kiwako Fujii, Kanako Ohnishi, Yasuo Matsumura
Lab.Pathol.and Mol.Pharmacol., Osaka Univ.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 196-196, 2009.

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P2N-A7-3 The mRNA expression of renal aquaporin-2 in rats with diabetes mellitus and the role of Astragalus Polysaccharidde

Bai Kang, Shumei Mao
Dept.Pharmacology of Weifang Medical Univercity
Journal of Pharmacological Sciences 109 (suppl.2) 196-196, 2009.

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P2N-A7-4 An opioid κ receptor antagonist nor-binaltorphimine improves ischemia/reperfusion-induced renal dysfunction in mice

Junpei Mutoh1, Masahiro Ohsawa2, Hiroaki Hisa1
1Second Dept.Pharmacol.Kyushu Univ.of Health and Welfare Sch.Pharm., 2Dept.Pathophysiol.Ther., Sch.Pharm.Pharm.Sci., Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 197-197, 2009.

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P2N-A7-5 Preventive effect of SA13353, a novel transient receptor potential vanilloid 1 agonist, on ischemia/reperfusion-induced renal injury in rats

Tomoko Hirata1, Fumio Tuji2, Kyoko Ueda1, Kenji Ueda2, Masaaki Murai2, Hiroyuki Aono2, Masanori Takaoka3, Yasuo Matsumura1
1Lab.Pathol.and Mol.Pharmacol., Osaka Univ.Pharmaceut., 2Research and Development Center, Santen Pharmaceutical Co., Ltd., 3Lab.Cell.Biol., Osaka Univ.Pharmaceut
Journal of Pharmacological Sciences 109 (suppl.2) 197-197, 2009.

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P2N-A7-6 Effects of XJE on blood pressure variability and its mechanism in conscious renovascular hypertensive rats

Lv Gui-Yuan1, Chen Su-Hong2, You Yong-Zhen1, Zhu Yun-Wei1
1Zhejiang Chinese Medical University, 2Wenzhou Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 197-197, 2009.

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P2N-A7-7 Hemodialysis-induced hypotension and autonomic nervous system activity in elderly chronic dialysis patients

Makie Higuchi, Aya Sasaki, Hiroaki Furukata
Div.Pharmacol., Kyushu Univ.of Nurs.& S.W
Journal of Pharmacological Sciences 109 (suppl.2) 197-197, 2009.

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P2N-A7-8 Effects of cilnidipine on intrarenal renin-angiotensin system, oxidative stress and renal injury in SHR/ND rats

Yu-Yan Fan1, Masakazu Kohno1, Daisuke Nakano2, Hirofumi Hitomi2, Hiroyuki Kobori3, Toshiro Fujita4, Shoji Kimura2, Akira Nishiyama2
1Dept.Internal Medicine.Kagawa Univ., 2Dept.Pharmacol., Kagawa Univ., 3Tulane Univ.Health Sciences Center, 4Dept.Neph.Endocrinol, Univ.Tokyo Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 198-198, 2009.

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P2N-A8-1 Angiotensin II shifts insulin signaling from glucose metabolism to cellular hypertrophy in rat vascular smooth muscle cells

Hirofumi Hitomi1, Kumiko Kaifu2, Hideyasu Kiyomoto2, Masakazu Kohno2, Daisuke Nakano1, Shoji Kimura1, Akira Nishiyama1
1Dept.Pharmacol., Kagawa Univ.Sch.Med., 2Dept.Internal Medicine, Kagawa Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 198-198, 2009.

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P2N-A8-2 Sympathetic regulation of arterial tonus via TRPC3/NCX1 coupling

Satomi Kita1, Takuya Iyoda1, Yuji Arai2, Issei Komuro3, Ryuji Inoue4, Kenta Kato5, Shigeki Kiyonaka5, Yasuo Mori5, Takahiro Iwamoto1
1Dept.Pharmacol., Fac.Med., Fukuoka Univ., 2Bioscience, Natl.Cardiovasc.Ctr.Res.Inst., 3Dept.Cardiovasc.Sci.and Med., Chiba Univ.Grad.Sch.Med., 4Dept.Physiol., Fac.Med., Fukuoka Univ., 5Dept.Synth.Chem.and Biol.Chem.Grad.Sch.Engineer., Kyoto Univ., Katsura Campus
Journal of Pharmacological Sciences 109 (suppl.2) 198-198, 2009.

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P2N-A8-3 Contribution of phospholipase A2 to U46619-induced vascular contraction in rat aorta

Kimiaki Suzuki, Ami Nishijima, Shin-ya Saito, Tomohisa Ishikawa
Dept.Pharmacol., Grad.Sch.Pharmaceut.Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 109 (suppl.2) 198-198, 2009.

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P2N-A8-4 Reduced function of Ca2+ efflux pathways in the resting state of femoral arteries from spontaneously hypertensive rats(SHR)

Masahisa Asano, Yukiko Nomura
Dept.Pharmacol., Grad.Sch.Med.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 109 (suppl.2) 199-199, 2009.

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P2N-A8-5 Effects of shikonin on the acetylcholine-induced relaxation response of vascular smooth muscle

Hiromi Takano-Ohmuro, Lucia S.Yoshida, Kaoru Irie, Toshiyuki Himi, Yasukatsu Yuda, Tomie Kawada
Fac.Pharmacy & Res.Inst.Pharmaceutical Sci., Musashino Univ
Journal of Pharmacological Sciences 109 (suppl.2) 199-199, 2009.

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P2N-A8-6 Losartan improves impairment of endothelial PDK1/Akt pathway-derived relaxation in aortas from diabetic rats with systemic hyperinsulinemia

Tsuneo Kobayashi, Kumiko Taguchi, Shingo Nemoto, Takayuki Matsumoto, Katsuo Kamata
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 199-199, 2009.

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P2N-A8-7 The mechanisms of enhanced vasoconstriction to endothelin-1 in mesenteric arteries from Goto-Kakizaki rats, a model of type 2 diabetes.

Keiko Ishida, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 199-199, 2009.

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P2N-A8-8 Effect of long-term streptozotocin-induced diabetes on coronary vasoconstriction in isolated perfused rat heart

Yuta Ozawa, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 200-200, 2009.

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P2N-A9-1 APP is up-regulated by amyloid beta oligomer in retinal ganglion cell

Kazuhiro Tsuruma1, Masamitsu Shimazawa2, Hideaki Hara1, 2
1Dept.Biofunct.Eval., Mol.Pharmacol., Gifu Pharmaceut.Univ., 2Dept.Biofunct.Mol, Gifu Pharmaceut.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 200-200, 2009.

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P2N-A9-2 Kallidinogenase inhibits the retinal neovascularization in vitro and in vivo

Shinsuke Nakamura1, Hiroshi Izuta1, Kazuhiro Tsuruma1, Masamitsu Shimazawa2, Hideaki Hara1, 2
1Dept.Biofunct.Eval., Mol.Pharmacol., Gifu Pharmaceut.Univ., 2Dept.Biofunct.Mol., Gifu Pharmaceut.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 200-200, 2009.

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P2N-A9-3 Hyperglycemia accelerates endothelial dysfunction of retinal blood vessels in rats

Orie Saigo, Asami Mori, Kenji Sakamoto, Tutomu Nakahara, Kunio Ishii
Dept.Mol.Pharmacol., Kitasato Univ.Sch.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 200-200, 2009.

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P2N-A9-4 Apelin is required for the development of oxygen-induced retinopathy

Atsushi Kasai1, Toshihiko Kinjo1, Yasuhiro Yoshioka1, Akiko Yamamuro1, Norihito Shintani2, Hitoshi Hashimoto2, 3, Akemichi Baba2, Sadaaki Maeda1
1Dept.Pharmacotherap., Faculty Pharm.Sci.Setsunan.Univ., 2Lab.Mol.Neuropharmacol., Grad.Sch.Pharmaceut.Sci, Osaka Univ., 3Center for Child Mental Dev., Grad.Sch.Med, Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 201-201, 2009.

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P2N-A9-5 Effects of tempol and L-nitroarginine methyl ester on hearing loss induced by intense noise

Reiko Nagashima, Natsuko Watanabe, Kiyokazu Ogita
Dept.Pharmacol., Setsunan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 201-201, 2009.

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P2N-A9-6 A new behavioral method for evaluating irritable behavior using ultrasonic vocalizations in rat

Yusuke Yamada, Kenichi Mishima, Keiichi Irie, Kazunori Sano, Syutaro Katsurabayashi, Kotaro Takasaki, Katunori Iwasaki, Michihiro Fujiwara
Dept.Neuropharmacol., Fukuoka Univ.Sch.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 201-201, 2009.

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P2N-A9-7 In silico modeling of mechanism of formation of endocochlear potential in inner ear

Fumiaki Nin1, 2, 4, Hiroshi Hibino1, Shingo Murakami1, Taishin Nomura3, Yoshihisa Kurachi1
1Dept.Pharmacol., Grad.Sch.Med., Osaka Univ., 2Dept.Otolaryngol., Kyoto Pref.Sch.Med., 3Dept.Mec.Sci.Bioeng., Grad.Sch.Eng.Sci.Osaka Univ., 4Kyoto First Red Cross Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 201-201, 2009.

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P2M-A10-1 Membrane components and phosphatidylethanolamine activate anandamide-generating phospholipase D

Jun Wang1, 2, Li-Ying Zhao1, 3, Yasuo Okamoto1, Toru Uyama1, Kazuhito Tsuboi1, Natsuo Ueda1
1Dept.Biochem., Kagawa Univ.Sch.Med., 2Dept.Anesthesiol., 1st Affiliated Hosp., China Med.Univ., 3Dept.Stomatol.China Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 202-202, 2009.

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P2M-A10-2 Activation of Nav1.7Na+ channel phosphorylates ERK and p38 MAPK, but not JNK, in adrenal chromaffin cells

Satoshi Miyazaki, Takayuki Nemoto, Tasuku Kanai, Toshihiko Yanagita, Akihiko Wada
Dept.Pharmocol., Miyazaki Univ
Journal of Pharmacological Sciences 109 (suppl.2) 202-202, 2009.

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P2M-A10-3 Roles of an angiotensin II receptor, AT1a signaling in wound healing and angiogenesis

Maya Kurosaka1, 2, Hiroto Sakamoto1, Tatsunori Suzuki1, Kanako Hosono1, Yoshikuni Fujita2, Masataka Majima1
1Dept.Pharmacol., Kitasato Univ.Sch.Med., 2Dept.Endocrinol., Kitasato Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 202-202, 2009.

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P2M-A10-4 The important role of glutamic acid-195 in pH-dependency of N-acylethanolamine hydrolyzing acid amidase

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P2M-A10-5 A novel indicator to determine the Mitochondrial pH in cultured living β-cell

Makiko Ogata1, Takeo Awaji2, Naoko Iwasaki1, Risa Fujimaki1, Miho Takizawa1, Yasuhiko Iwamoto1, Kei Maruyama2
1Diabetes Center, Tokyo Women's Med.Univ., 2Dept.Pharmacol., Saitama Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 203-203, 2009.

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P2M-A10-6 LXT-101, a new potent gonadotropin-releasing hormone antagonist, inhibits LNCap cell growth through interfering androgen and EGF signal transduction pathways

Chi Xiaoli, Zhou Wenxia, Zhang Yongxiang, Liu Keliang
Beijing Institute of Pharmacology and Toxicology
Journal of Pharmacological Sciences 109 (suppl.2) 203-203, 2009.

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P2M-A10-7 Effects of ROS scavengers on learning impairment brought on by alloxan-induced diabetes in mice

Yutaka Matsuoka, Aya Nagatomo, Takahiro Hashimoto, Masakazu Sawabe
Lab.Medicinal Sci., Fac.Pharm.Sci., Tokyo Univ.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 203-203, 2009.

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P2M-A10-8 In vitro and in vivo characterization of an orally-active 11 beta-HSD1 selective inhibitor, M67633

Yusuke Shimizu, Manabu Itoh, Yutaka Miyazaki, Masahiko Ohta, Hiroyuki Muramatsu, Shigeki Matsumoto, Hiroyasu Naba, Masashi Mizuno, Takayuki Egusa, Emi Akiyama, Kanako Nishimura, Natsuko Yuge, Ikuya Shiromizu, Yoshitaka Hosaka, Hidemitsu Nishida, Tomokazu Matsusue, Fumiaki Yamasaki, Ichiro Yamamoto, Shoji Furusako, Yasuo Isomura
Discovery Research, Mochida Pham.CO., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 203-203, 2009.

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P2M-A11-1 Involvement of the PGE2-EP2-adenylate cyclase pathway in abscess formation in rat zymosan-induced pleurisy

Toshihisa Inada1, Michiko Kawamura2, Ko Hatanaka2, Yoshiteru Harada1
1Dept.Mediator and Signal Transduction Pharmacology, Kitasato Univ.Graduate Sch.Medical Sciences, 2Dept.Molecular Pharmacology, Kitasato Univ.Graduate Sch.Medical Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 204-204, 2009.

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P2M-A11-2 Transforming Growth Factor-β as a biomarker of peritoneal membrane function in peritoneal dialysis patients

Tomoyo Niimi1, Yasuhiko Ito2, Yasuhiro Suzuki2, Masashi Mizuno2, Seiichi Matsuo2, Yukihiro Noda1
1Divi.Clin.Sci.Neuropsychopharmacol., Meijo Univ.Grad.Sch.Pharm.Sci., 2Dept.Nephrol.Renal Repl.Therapy, Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 204-204, 2009.

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P2M-A11-3 CORM(carbon monoxide release molecule)-2 inhibits TNF-α release from activated-RBL-2H3 cells

Yumiko Nishii, Miho Watanabe, Akina Maruyama, Nobuaki Matsui, Nobuyuki Fukuishi, Masaaki Akagi
Dept.Pharmacol., Tokushima Bunnri Univ
Journal of Pharmacological Sciences 109 (suppl.2) 204-204, 2009.

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P2M-A11-4 Effects of extracellular purine on histamine release via Fcε RI in human lung mast cells

Haruhisa Nishi1, Amir Pelleg2, Manfred Thile3, Edward S.Schulman2
1Dept.Pharmacol., Jikei Univ.Sch.Med., 2Drexel Univ.Col.Med., 3LMU
Journal of Pharmacological Sciences 109 (suppl.2) 204-204, 2009.

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P2M-A11-5 Effect of doxorubicin on histamine release from mast cells

Masakazu Hanayama, Kazutaka Maeyama
Dept.Pharmacol.Informational Biomedicine, Ehime Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 205-205, 2009.

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P2M-A11-6 The uptake of τN-methylhistamine, a metabolite of histamine, in mast cells reduce its histamine content

Yusuke Oogi, Martin Maldonado, Kazutaka Maeyama
Dept.Pharmacol.Informational Biomedicine, Ehime Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 205-205, 2009.

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P2M-A11-7 H1521, a novel derivative of 4-hydroxyquinoline-3-carboxamide, suppresses the development of mice lupus by inducing Th1 cytokine profile in CD4+ T cells

Yongxiang Zhang, Zhiyong Xiao, Wenxia Zhou, Junping Cheng, Rifang Yang, Liuhong Yun
Beijing Institute of Pharmacology and Toxicology
Journal of Pharmacological Sciences 109 (suppl.2) 205-205, 2009.

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P2M-A12-1 Comprehensive evaluation of safety pharmacology core battery for the monkey in a novel chamber of whole-body plethysmography

Kazuaki Sasaki, Norio Odagiri, Yasuo Nakamura, Hiroizumi Yamanaka, Chengjun Ma, Masakazu Imaizumi, Hiroshi Atai, Hiromi Iizuka, Katsuhide Nishi
Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 205-205, 2009.

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P2M-A12-2 Respiratory function measured by whole body plethysmography in mice

Kennosuke Akiyama, Michiko Ashina, Takayuki Shinozuka, Yoshio Mastumoto, Hiromi Iizuka, Keitaro Hashimoto, Yasushi Yamashita
Kashima Lab, Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 206-206, 2009.

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P2M-A12-3 Validation for respiratory function measurement in free-moving cynomolgus monkeys

Atsushi Fujiwara1, Masahiko Iino1, Mitsuru Hoshino1, Takayuki Kato1, Kengo Sakamoto1, Yoshio Wakasa1, Shinichi Kitani1, Masako Onotogi1, Shinichi Sato1, Elie Braun2, Sachihiko Okubo3, Mamoru Nomura1
1Ina Research Inc., 2VivoMetrics Inc., 3LSG Co
Journal of Pharmacological Sciences 109 (suppl.2) 206-206, 2009.

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P2M-A12-4 Involvement of alveolar epithelial cell on Methotrexate-induced pulmonary toxicity

Masayuki Ohbayashi, Ayaka Shiozawa, Masako Yasuda, Noriko Kohyama, Yasuna Kobayashi, Toshinori Yamamoto
Dept.Clinical Pharmacy., Showa Univ.Sch.Ph
Journal of Pharmacological Sciences 109 (suppl.2) 206-206, 2009.

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P2M-A12-5 Study of activity of potassium channel and production cytokine of alveolar macrophages in a rodent asthma model

He Su-Rong, Di An-Ke, Ju Xue-Peng, Bai Xue-Feng, Wei Minjie, Yao Wei-Fan
Department of Pharmacology, China Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 206-206, 2009.

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P2M-A12-6 Research on pharmacological mechanism of the treatment of asthma by oral Bordetella pertussis

Sun Yun, Chi Shen, Zhang Baoyuan
Dept.Pharmacol., School of Med.Yangzhou Univ
Journal of Pharmacological Sciences 109 (suppl.2) 207-207, 2009.

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P2L-A13-1 Asymmetric expression of mature miRNAs from miRNA clusters depends on the length of interval sequence between two miRNA precursors

Atsushi Shibata1, Sayo Kaneko2, Noriyoshi Teramoto1
1Dept.Pharmacol.Sci., Grad.Sch.Med.Sci., Kyushu Univ., 2Div.Hum.Mole.Genet., Res.Ctr.Genet.Info., Med.Inst.Bioreg., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 207-207, 2009.

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P2L-A13-2 Gene cloning, expression analysis of ACP(Acyl Carrier Protein)in Jatropha curcas L.and its prokaryotical expression

Jiang Lu-Ding, Li Xiao-Hui
Dept Pharm., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 207-207, 2009.

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P2L-A13-3 Gene expression profiling for identifying culture-stage markers of human mesenchymal stem cells

Shihori Tanabe1, Yoji Sato1, Takayoshi Suzuki1, Kazuhiro Suzuki1, Teruhide Yamaguchi2
1Div.Cell.Gene Ther.Prod., Natl.Inst.Health Sci., 2Div.Biol.Chem.Biol., Natl.Inst.Health Sci
Journal of Pharmacological Sciences 109 (suppl.2) 207-207, 2009.

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P2L-A13-4 A novel seven-transmembrane receptor DCAR-1 mediates avoidance response to a water-soluble repellent in C.elegans

Reina Aoki1, Tatsurou Yagami2, Ken-ichi Ogura1, Hiroyuki Sasakura4, Takeaki Miyamae1, Fumio Nakamura1, Yasuhiro Kajihara3, Naoki Yamamoto3, Ikue Mori4, Yoshio Goshima1
1Dept.Mol.Pharmacol.& Neurobiol., Yokohama City Univ.Grad.Sch.Med., 2Facl.Pharmath.Sci., Himeji Dokkyo Univ., 3Bioorg.Chem.& Carbo.Chem., Yokohama City Univ., Inter.Grad.Sch.of Art & Sci., 4Dept.of Mol.Biol.Divis.of Bio.Sci., Grad.Sci.Nagoya Univ
Journal of Pharmacological Sciences 109 (suppl.2) 208-208, 2009.

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P2L-A13-5 Association analysis between the protein tyrosine phosphatase, receptor-type, Z polypeptide 1(PTPRZ1)gene and schizophrenia in the Japanese population

Shinnosuke Yamada1, Yoshihito Ito2, Akira Yoshimi1, Yukihiro Noda1, Norio Ozaki2
1Divi.Clin.Sci.Neuropsychopharmacol.Grad.Sch.Pharm.Sci.Meijo Univ., 2Dept.Psychiatr.Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 208-208, 2009.

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P2L-A13-6 Effect of astragalosides on the expression of BDNF, TrkB and p75NTR mRNA against focal cerebral ischemia-reperfusion injury

Yan-yan Yin, Wei-ping Li, Wei-zu Li, Hui-ling Gong, Fen-fang Zhu
Dept of Pharm Acology, AnhuiM Edical University
Journal of Pharmacological Sciences 109 (suppl.2) 208-208, 2009.

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P2L-A13-7 Expression of microRNA in brown adipose of spontaneous diabetic mice treated with pioglitazone

Tohru Masuzawa1, Tomohiro Yamamoto2, Noriyuki Yamazaki1, Morie Nishiwaki2
1New Drug Development Research Center Inc., 2GLab Pathology Center Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 208-208, 2009.

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P2L-A13-8 Zymographic analysis of Streptococcus criceti autolysin Atla

Haruki Tamura, Arisa Yamada, Hirohisa Kato
Dep.Dent.Pharmacol., Sch.Dent., Iwate Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 209-209, 2009.

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P2L-A14-2 The effect of imipramine on cultured rat embryos in the medium containing S-9mix

Masaharu Akita1, Noriko Ishizuka1, Atsushi Yokoyama2, Hitoshi Kontani3
1Dept.Nutrition and Dietetics, Faculity of Family and Consumer Sciences, Kamakura Women's Univ.kanagawa., 2Kanagawa Life Science Research Labo
Journal of Pharmacological Sciences 109 (suppl.2) 209-209, 2009.

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P2L-A14-3 Effects of herbalteas on CYP1A, CYP2C and CYP2D-mediated metabolic activities

Yuki Nishimura1, Norimitsu Kurata1, 2, Mariko Iwase1, Hajime Yasuhara1
1Dept.Pharamacol.Sch.Med.Showa Univ., 2Facult.Arts Sci
Journal of Pharmacological Sciences 109 (suppl.2) 209-209, 2009.

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P2L-A14-4 Inhibitory effects of bromhexine and ambroxol on cytochrome P450 activity in human liver microsome

Mariko Iwase1, Norimitsu Kurata1, 2, Yuki Nishimura1, Hajime Yasuhara1
1Dept.Pharmacol., Showa Univ.Sch.Med., 2Facult.Arts Sci.Showa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 209-209, 2009.

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P2L-A14-5 Pharmacokinetic and bioequivalence evalution of two nimodipine sustained-release tablets in Chinese healthy male volunteers

Liu Mingyan, Wu Huizhe, Guo Haijie, Wei Minjie
Department of Pharmacology, China Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 210-210, 2009.

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P2L-A14-6 Pharmacokinetics of ginkalide B injection after a single dose in Chinese healthy volunteers

Li Guo-xin, Xia Su-xia, Wang Yue-min, Tang Si
Laboratory of Clinical Pharmacology, Academic of Traditional Chinese Medicine of Liaoning Province
Journal of Pharmacological Sciences 109 (suppl.2) 210-210, 2009.

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P2L-A14-7 Comparision study pharmacokinetics of different source cinnamon acid

Li Wen-lan, Su Xiang-ming, Ji Yu-bin, Hu Zheng-ting, Ren Xiao-lei, Whang Jia
Center of Research on Life Sciences and Environmental Sciences, Harbin University of Commerce
Journal of Pharmacological Sciences 109 (suppl.2) 210-210, 2009.

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P2L-A15-1 Pharmacokinetics and bioequivalence study on diclofenac sodium sustain-released tablet in healthy volunteers

Wen Xiaoyan, Liu Mingyan, Wu Huizhe, Wei Minjie
Department of Pharmacology, China Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 210-210, 2009.

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P2L-A15-2 Macrophage inflammatory protein-1 α participates in nerve injury-induced neuropathic pain

Norikazu Kiguchi, Takehiko Maeda, Yuka Kobayashi, Shiroh Kishioka
Dept.Pharmacol., Wakayama Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 211-211, 2009.

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P2L-A15-3 Involvement of pituitary adenylate cyclase-activating polypeptide(PACAP)in diabetic neuropathy

Keigo Ikeda1, Takao Shimizu1, Makiko Yokoi1, Tetsuya Onou2, Kazuhiko Inoue1, Atsuro Miyata1
1Dept.Phamacol., Kagoshima Univ.Grad.Sch.Med.Dent.Sci., 2Dept.Anesthesiol., Kagoshima Univ.Grad.Sch.Med.Dent.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 211-211, 2009.

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P2L-A15-4 Picrotoxin Antagonizes Diazepam-Induced Hypoglossal Inhibition and Enhances Effects of Flumazenil

Shinichi Nakamura1, Masahiko Suzuki2, Kei Maruyama3, Hirosato Kikuchi1
1Dept.Anesth., Saitama Med.Univ., 2Lab.Pharmacol., Saitama Med.Univ., 3Dept.Pharmacol., Saitama Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 211-211, 2009.

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P2L-A15-5 Ubiquitination of SIMPLE, a causative gene for Charcot-Marie-Tooth disease type 1C, in Schwann cell line IMS-32

Mina Mizunuma
Dept Pharmacol, Fac Pharm Keio Univ
Journal of Pharmacological Sciences 109 (suppl.2) 211-211, 2009.

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P2L-A15-6 Involvement of peripheral glutamate receptors in capsaicin-induced nociceptive processing

Fumiko Yamaki1, Yuichi Koike2, Yoshinobu Takata1, Norifumi Yonehara1
1Dept.Pharmacol., Ohu Univ.Sch.Pharmceu.Sci., 2Dept.Drug Metabo.and Clin.Pharmacokinet
Journal of Pharmacological Sciences 109 (suppl.2) 212-212, 2009.

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P2L-A15-7 Spheres derived from the mouse embryonic intestine developed gut-like tissue demonstrating spontaneous rhythmic contractions in vitro

Yukiko Tanaka, Satoko Morikawa, Haruka Miyake, Kazuhiko Oishi
Dept.Pharmacol., Meiji Pharmaceutical Univ
Journal of Pharmacological Sciences 109 (suppl.2) 212-212, 2009.

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P2L-A15-8 p75+/c-Kit+ cells isolated from the mouse embryonic intestine developed gut-like tissue demonstrating spontaneous rhythmic contractions in vitro

Satoko Morikawa, Yukiko Tanaka, Haruka Miyake, Kazuhiko Oishi
Dept.Pharmacol., Meiji Pharmaceutical Univ
Journal of Pharmacological Sciences 109 (suppl.2) 212-212, 2009.

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P2L-A16-1 Roles of an inducible prostaglandin E synthase, mPGES-1 in the healing of acetic acid-induced gastric ulcer

Takako Ae1, 2, Takashi Ohno1, 2, 3, Youichirou Hattori2, 4, Katsunori Saigenji2, Masataka Majima1
1Dept.Pharmacol., Kitasato Univ Sch.Med, 2Dept.Gastroenterolgy., Kitasato Univ Sch.Med, 3Isehara Kyodo Hosp., 4Hiratsuka Kyosai Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 212-212, 2009.

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P2L-A16-2 Effect of polydatin on inflammatory response during gastric ischemia reperfusion injury

Jie-yun Guo, Wei-zhong Zhao
Dept of Pharmacology, Anhui Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 213-213, 2009.

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P2L-A16-3 Role of RhoA in atorvastatin-induced hepatocyte injury

Midori Kakumori1, 2, Asuka Maeda1, Toshio Kubota2, Takahisa Yano2, Nobuaki Egashira1, 2, Ryozo Oishi1, 2
1Grad.Sch.Pharm.Sci., Kyushu Univ., 2Dept.Pharmacy, Kyushu Univ.Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 213-213, 2009.

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P2L-A16-4 Tumor necrosis factor(TNF)receptor-2-mediated DNA synthesis and proliferation in primary cultures of adult rat hepatocytes

Mitsutoshi Kimura, Hiroshi Okamoto, Masahiko Ogihara
Dept.Clinical Pharmacol., Fac.Pharmac.Sci., Josai Univ
Journal of Pharmacological Sciences 109 (suppl.2) 213-213, 2009.

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P2L-A16-5 Effects of bezafibrate on nonalcoholic steatohepatitis in rats fed methionine-and choline-deficient diet

Toshinori Moritani, Takashi Shimosato, Noriko Minobe, Daisuke Saji, Hitomi Matsuda, Miki Shirahata, Mikito Kikumori, Hiroko Yamanaka, Ayahito Kimura, Shigenori Furukawa
NISSEI BILLS Co., Ltd., Shiga Laboratory
Journal of Pharmacological Sciences 109 (suppl.2) 213-213, 2009.

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P2L-A16-6 Preventive effects of 1-O-hexyl-2, 3, 5-trimethyl hydroquinone(HTHQ)against the carbon tetrachloride(CCl4)-treated liver fibrosis

Jun An1, 2, Guo-Gang Feng2, Lei Huang2, Tsuyoshi Kurokawa1, Toshiaki Nonami1, Tatsuro Koide3, Jun-Hua Fan1, 4, Fumio Kondo2, Naohisa Ishikawa2
1Dept.Gastroenterogical Surgery, Aichi.Med.Univ, 2Dept.Pharmacol, Aichi.Med.Univ, 3Health Reserch Center, Aichi Gakuin Univ, 4Dept.Gastroent Int Med, Nagoya Univ
Journal of Pharmacological Sciences 109 (suppl.2) 214-214, 2009.

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P2L-A16-7 The enhancement of mouse small intestine transit by SART stress and a serotonergic nerve

Yoshinori Funakami1, 2, Eiji Itoh2, Taeko Hata2, Tetsuyuki Wada1, Seiji Ichida1
1Dvi.Biochem., Dept.Pharm., Sch.Parm., Kinki Univ., 2Dept.Pharmacol., Sch.Pharm., Kinki Univ
Journal of Pharmacological Sciences 109 (suppl.2) 214-214, 2009.

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P2L-A16-8 Effect of mosapride citrate hydrate on the colon cleansing action of polyethylene glycol electrolyte lavage solution(PEG-ELS)in guinea pigs

Yukiko Mine, Kazuo Morikage, Seiko Oku, Isao Shimizu, Naoyuki Yoshida
Pharmacology Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 214-214, 2009.

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P2L-A17-1 P2X7 receptor-mediated cell lysis in murine T lymphocytes

Hitoshi Harada, Ko Misaka, Masakuni Degawa
Sch.of Pharma.Sci., Univ.of Shizuoka
Journal of Pharmacological Sciences 109 (suppl.2) 214-214, 2009.

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P2L-A17-2 The effect of SUN N8075 on retinal ganglion cell death

Rumi Uchibayashi1, Masamitsu Shimazawa2, Kazuhiro Tsuruma1, Hideaki Hara1, 2
1Dept.Biofunct.Eval., Mol.Pharmacol., Gifu Pharmaceut.Univ., 2Dept.Biofunct.Mol., Gifu Pharmaceut.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 215-215, 2009.

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P2L-A17-3 MiR-122 induced apoptosis and increased sensitivity to 5-Fluorouracil in BEL-7402/5-FU cell line

Yin Jie, Lei Xiao-Yong, Yu Jia, Xiang Qiong, Zhu Bing-Yang, Tang Sheng-Song, Liao Duan-Fang
Institute of Pharmacy and Pharmacology, South China University
Journal of Pharmacological Sciences 109 (suppl.2) 215-215, 2009.

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P2L-A17-4 Apoptosis induced by betaine in HepG2 cells

Gao Shi-Yong1, 2, Ji Yu-Bin1, 2, Yang Hong-Dan1, 2, He Li-Wei1, 2
1Postdoctoral Research Station, Institute of Matetia Medica, Life Sciences and Environmental Sciences Research Center, Harbin University of Commerce., 2MOE Engineering Research Center of Natural Anticancer Drugs, Harbin Commerce University
Journal of Pharmacological Sciences 109 (suppl.2) 215-215, 2009.

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P2L-A17-5 Molecular basis for the enhanced expression of major vault protein(MVP)under hyperosmotic stress

Yusuke Tajitsu1, Ryuji Ikeda2, Ken-ichi Iwashita1, Yasuo Takeda1, 2, Sho Tabata1, Yukihiko Nishizawa1, Mina Ushiyama2, Tatsuya Yamaguchi2, Masatatsu Yamamoto3, Xiao-Fang Che3, Tatsuhiko Furukawa3, Shin-ichi Akiyama3, Katsushi Yamada1, 2
1Dept.Clin.Pharm.and Pharmacol., Grad.Sch.Med.Dent.Sci., Kagoshima Univ., 2Dept.Clin.Pharm., Kagoshima Univ.Hosp., 3Dept.Mol.Oncology, Grad.Sch.Med.Dent.Sci., Kagoshima Univ
Journal of Pharmacological Sciences 109 (suppl.2) 215-215, 2009.

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P2L-A17-6 Cytoprotective effects of hydrogen sulfide in mouse pancreatic islets

Shigeki Taniguchi1, Yukiko Kaneko2, Toshihide Kimura1, Ichiro Niki1
1Dept.Pharmacol., Oita Univ.Fac.Med., 2Dept.Pharmacol., Sch.Pharmaceutical Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 109 (suppl.2) 216-216, 2009.

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P2L-A17-7 Protective effect of plasmenylethanolamine against cortex mitochondria injury induced by hydroxyl radicals

Shuping Zhang
Department of Pharmacology, Binzhou Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 216-216, 2009.

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P2L-A18-1 The effect of PACAP on schizophrenia model mice by MK801

Makiko Yokoi1, Keigo Ikeda1, Takao Shimizu1, Masayuki Nakamura2, Kazuhiko Inoue1, Atsuro Miyata1
1Dept.Pharmacol., Kagoshima Univ.Grad.Sch.Med.Dent.Sci., 2Dept.Psych, Kagoshima Univ.Grad.Sch.Med.Dent.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 216-216, 2009.

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P2L-A18-2 Effects of drugs on panic-like behavior of olfactory bulbectomized rats

Tomomi Matsuda1, Hiroyasu Murasawa1, Akiko Nakatani1, Kyoko Matsuzawa1, Yoshimi Tatsumi2, Morio Tatsumi2, Tohru Toyoshi1, Kazumasa Yamaguchi1
1Nihon Bioresearch Inc., 2Narabyouri Research Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 216-216, 2009.

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P2L-A18-3 Role and regulation of potassium channels in neuronal apoptosis in AD models

Xiaoliang Wang, Jiang Li, Ling Wang, Nan Feng
Institute of Materia Medica, Chinese Academy of Medical Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 217-217, 2009.

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P2L-A18-4 The Parkinson's disease model induced by rotenone nanostructured lipid carriers in rats

Ge Xiao-qun1, 2, Liu Hong1, Guo Rong2
1Dept.Pharmacol., Med.College, 2School of Chemistry and Chemical Engineering, Yangzhou Univ
Journal of Pharmacological Sciences 109 (suppl.2) 217-217, 2009.

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P2L-A18-6 Over-expressed transmembrane protein 21 inhibits secretase in γ-APP knockout mouse embryonic fibroblasts

Yue Jiang1, Guicheng Dong2, 3, Shaoying Li2, Zhonghua Meng2, Chenghui Liu1
1Whuhan University, Basic Medicine School of WuHan University, 2Baotou Teacher College of Innermongolia Technology and Science University, 3Faculity Food Science and Engineering, of Inner Mongolia Agriculture University
Journal of Pharmacological Sciences 109 (suppl.2) 217-217, 2009.

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P2L-A18-7 Evaluation of the method in adenine-induced renal failure model rats

Naomi Hikawa, Kousuke Morizumi, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi, Masahiro Nasu, Chiemi Koga
Mitsubishi Chemical Safety institute Ltd., Kumamoto Laboratory, Department of pharmacology
Journal of Pharmacological Sciences 109 (suppl.2) 217-217, 2009.

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P2L-A18-8 Mcroglial neuroprotection is regulated by P2X7 receptor in rat ischemic brains

Koichiro Yamane1, Yoshihisa Kitamura1, Kazuyuki Takata1, Hide Izumi2, Yoshihiro Nakata2, Takashi Taniguchi1
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2Dept.Pharmacol., Grad.Sch.Biomed.Sci., Hiroshima Univ
Journal of Pharmacological Sciences 109 (suppl.2) 218-218, 2009.

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P2O-P1-1 Effect of Limai Capsula on the Learning Memory Abilities of Mice

Min Zheng, Ji-liang Wu, Banghua Wang, Ji Zhao, Chang-han Ouyang, Fei Cai
Department of Pharmacology, Xianning College
Journal of Pharmacological Sciences 109 (suppl.2) 218-218, 2009.

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P2O-P1-2 Memory enhancement by icariin and the molecular mechanism underlying the effect

Chihiro Tohda, Takuya Urano, Eri Joyashiki, Aiko Nagata, Kiyoshi Teshigawara
Div.Biofunctional Evaluation, Inst.Natural Med., Univ.Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 218-218, 2009.

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P2O-P1-3 Analysis of behavioral abnormality in rats with thioacetamide-induced liver damage

Hiroshi Kawai, Atsushi Mitsumoto
Fac.Pharmceut.Sci., Josai Int.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 218-218, 2009.

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P2O-P1-4 Behavioral studies on FG7142-induced anxiety-related behaviors in mice

Ken-ichi Tanaka1, Takao Yagi1, 2, Takeshi Nanba1, 2, Hiromi Abe1, Yuriko Matsumura1, Hiroya Ogo1, 2, Akiko Tamura1
1Dept.Clin.Pharma., Shujitsu Univ.Sch.Pharma., 2Dept.Brain Sci., Okayama Univ.Grad.Sch.Med., Dent., Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 219-219, 2009.

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P2O-P1-5 Role of somatostatin receptors in the nucleus accumbens shell in rat turning behaviour

Ayako Kotani, Hiroko Ikeda, Noriaki Koshikawa
Dept.Pharmacol., Nihon Univ.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 219-219, 2009.

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P2O-P1-6 Investigation of social behavioral characteristics and strain differences by social interaction test in Lister hooded(LH)rats with anxiety-like behavior

Yoshiyuki Hayashida1, 2, Takahiro Inaba2, Hiromitsu Ono2, Hiroshi Ohta1, Hiroshi Atai1
1Pharmacology Division, Kumamoto Laboratory, Mitsubishi Chemical Safety Institute Ltd., 2Production Department, Kyudo Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 219-219, 2009.

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P2O-P1-7 Attempted establishment of 3-choice serial reaction time task:an efficient method for assessment of impulsivity control in rodents

Iku Tsutsui, Yu Ohmura, Taku Yamaguchi, Takeshi Izumi, Yasunori Kubo, Takayuki Yoshida, Mitsuhiro Yoshioka
Dept.Neuropharmacol., Hokkaido Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 219-219, 2009.

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P2O-P1-8 Chronic stress affects locomotor activity and synaptic plasticity in the anterior cingulate cortex in mice

Hiroshi Ito1, Takayuki Murakoshi1, Hidenori Suzuki2, Masatoshi Nagano2
1Dept.Life Science., Univ.Tokyo., 2Dept.Pharmacol., Nippon.Med.Sch
Journal of Pharmacological Sciences 109 (suppl.2) 220-220, 2009.

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P2O-P2-1 Phenotype of PRIP-1, 2 double knockout:spontaneous and drug-induced orofacial movements

Katsunori Tomiyama1, 2, Li Qiu Song2, Kazunori Adachi3, Anthony Kinsella4, Masayuki Kobayashi2, 5, Takashi Kanematsu6, Masato Hirata6, Noriaki Koshikawa2, 5, John Waddington4
1Life Science, Nihon Univ.ARISH, 2Dept.Pharmacol., Nihon Univ.Sch.Dent., 2Div.Pharmacol., Meikai Univ.Sch.Dent., 4Molecular & Cellular Therapeutics and RCSI Research Institute, 5Dental Res.Centre, Nihon Univ., 6Dept.Biochem., Fac.Dent., Kyusyu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 220-220, 2009.

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P2O-P2-2 Retrograde signalling is induced by endocannabinoids in the basolateral amygdala

Takayuki Yoshida1, Motokazu Uchigashima2, Hiroki Shikanai1, Takashi Izumi1, Taku Yamaguchi1, Masahiko Watanabe2, Mitsuhiro Yoshioka1
1Dept.Neuropharmacol., Hokkaido Univ.Grad.Sch.Med., 2Dept.Anatomy, Hokkaido Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 220-220, 2009.

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P2O-P2-3 Involvement of PPAR-γ in methamphetamine-induced neurotoxicity and protective effect of interferon-γ

Saki Fukuoka1, Hiroaki Hozumi1, Naotaka Kimoto2, Yuri Kikkawa2, Takeshi Tsuji2, Ikuko Miyazaki2, Yoshihisa Kitamura3, Toshiaki Sendo1, Taizo Kita4, Masato Asanuma2
1Dept.of Clinical Pharm., Okayama Univ.Grad.Sch.of Med., Dent.and Phamaceut.Sci., 2Dept.of Brain Sci., Okayama Univ.Grad.Sch.of Med., Dent.and Phamaceut.Sci., 3Dept.of Pharmaceutical Care and Health Sci., Okayama Univ.Grad.Sch.of Med., Dent.and Pharmaceut.Sci., 4Lab.of Phamacol., Kyushu Nutr.Welfare Univ.Grad.Sch.of Food and Nutr
Journal of Pharmacological Sciences 109 (suppl.2) 220-220, 2009.

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P2O-P2-4 Involvement of dopaminergic system on place aversion induced by naloxone in single-dose morphine-treated rats

Shigeru Ishida1, 2, Kazunori Morohashi1, Yuichi Ikuta1, Ken-ichiro Fuchi1, Yoichi Kawasaki1, Masato Asanuma3, Hiroaki Araki4, Toshiaki Sendo1, Yoshihisa Kitamura5, Hiromu Kawasaki2
1Dept.Clin.Pharm., Okayama Univ.Grad.Sch., 2Dept.Clin.Pharmaceut.Sci., Okayama Univ.Grad.Sch., 3Dept.Brain Sci., Okayama Univ.Grad.Sch., 4Dept.Clin.Pharmacol.Pharm., Ehime Univ.Grad.Sch., 5Dept.Pharmaceut.Care Heal.Sci., Okayama Univ.Grad.Sch
Journal of Pharmacological Sciences 109 (suppl.2) 221-221, 2009.

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P2O-P2-5 Drug interaction between etoposide and morphine

Eri Saeki, Wakako Hamabe, Ayaka Nawa, Shogo Tokuyama
Dept.Clinic.Pharm., Fac.Pharmaceu.Sci., Kobe Gakuin Univ
Journal of Pharmacological Sciences 109 (suppl.2) 221-221, 2009.

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P2O-P2-6 Effects of active fraction of Semen Ziziphi Spinosae on morphine induced CPP in mice

Chen Chong-Hong, Yu Hui-Min, Chen Shao-Ya
Depart.Pharmacology, Fujian Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 221-221, 2009.

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P2O-P2-7 Possible association of brain monoamine turnover with anxiety-like behavior in mice after withdrawal from methamphetamine

Nobue Kitanaka1, Junichi Kitanaka1, Koh-ichi Tanaka2, Tomohiro Tatsuta3, Kaname Watabe4, Yoshio Morita3, Nobuyoshi Nishiyama2, Motohiko Takemura1
1Dept.Pharmacol., Hyogo Col.Med., 1Div.Pharmacol., Dept.Pharm., Sch.Pharm., Hyogo Univ.Health Sci., 3Dept.Neuropsychiatry, Hyogo Col.Med., 4Tech.Dept., Muromachi Kikai, Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 221-221, 2009.

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P2O-P2-8 Specific neuronal contribution to the alteration of the expression pattern of methamphetamine-induced stereotypy in mice

Junichi Kitanaka1, Nobue Kitanaka1, Koh-ichi Tanaka2, Tomohiro Tatsuta3, Yoshio Morita3, Nobuyoshi Nishiyama2, Motohiko Takemura1
1Dept.Pharmacol., Hyogo Col.Med., 2Div.Pharmacol., Dept.Pharm., Sch.Pharm., Hyogo Univ.Health Sci., 3Dept.Neuropsychiatry, Hyogo Col.Med
Journal of Pharmacological Sciences 109 (suppl.2) 222-222, 2009.

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P2O-P3-1 Nociceptin and its metabolite improve U0126-induced memory impairment through NOP receptor-independent mechanism

Masaya Miwa1, Fumika Horiba2, Shogo Uchida1, Toshitaka Nabeshima2, Masayuki Hiramatsu1, 2
1Lab.of Neuropsychopharmacol., Grad.Sch.of Environ.and Human Sci., Meijo Univ., 2Dept.of Chem.Pharmacol., Fac.of Pharmac., Meijo Univ
Journal of Pharmacological Sciences 109 (suppl.2) 222-222, 2009.

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P2O-P3-2 Ascorbic acid inhibits hydrogen sulfide-induced hyperalgesia and paclitaxel-induced neuropathic pain

Kazumasa Okubo, Maho Matsunami, Kimie Onchi, Atsufumi Kawabata
Div.Pharmacol.Pathophysiol., Kinki Univ.Sch.Pharm
Journal of Pharmacological Sciences 109 (suppl.2) 222-222, 2009.

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P2O-P3-3 Peripheral hydrogen sulfide enhances C-fiber-mediated nociception and phosphorylation of ERK in spinal dorsal horn neurons

Yuka Aoki, Yumi Maeda, Maho Matsunami, Atsufumi Kawabata
Div.Pharmacol.Pathophysiol., Kinki Univ.Sch.Pharm
Journal of Pharmacological Sciences 109 (suppl.2) 222-222, 2009.

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P2O-P3-4 Co-adminstration of subeffective dose of ketamine with meloxicam reduce mechanical hyperalgesia but not thermal hyperalgesia in a rat model of inflammatory pain

Huang Cheng, Huang Zhi-Qin, Hu Zhi-Ping
Dept.Physiol, Gannan Medical Univ
Journal of Pharmacological Sciences 109 (suppl.2) 223-223, 2009.

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P2O-P3-5 Effects of TRK-820, a selective κ-opioid receptor agonist, on mechanical allodynia in partial sciatic nerve ligated rats or streptozotocin-induced diabetic rats

Chihiro Yoshida, Kaoru Nakao, Hidenori Mochizuki
Pharmaceutical Research Laboratories, Toray Industries, Inc
Journal of Pharmacological Sciences 109 (suppl.2) 223-223, 2009.

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P2O-P3-6 Synaptic activity in layer II/III pyramidal neurons of anterior cingulated cortex in neuropathic mice

Keisuke Migita1, Kenji Honda2, Yukio Takano2, Junko Yamada1, Shinya Ueno1
1Dept.Neurophysiol., Hirosaki Unive.Grad.Sch.Med., 2Dept.Physiol.Pharmacol., Fact.Pharmaceut.Sci., Fukuoka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 223-223, 2009.

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P2O-P3-7 Nociceptive stimulus increase hypothalamic histamine release in mice

Tomotaka Murotani1, Tomoko Ishizuka2, Kouichi Yamamoto1, Keiko Asano1, Kouhei Sakata1, Yui Honjo1
1Department of Medical Science and Technology, Graduate School of Allied Health Sciences, Faculty of Medicine, Osaka University, 2Department of Pharmacology, Osaka Dental University
Journal of Pharmacological Sciences 109 (suppl.2) 223-223, 2009.

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P2O-P4-1 Regulation of presynaptic differentiation by zebrafish orthologue of mental retardation protein IL1RAPL1

Tomoyuki Yoshida, Masayoshi Mishina
Dept.of Mol.Neurobiol.& Pharmacol., Grad.Sch.of Med., Univ.of Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 224-224, 2009.

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P2O-P4-2 Regulation of DARRP-32 phosphorylation by muscarinic receptors via presynaptic and postsynaptic mechanisms in the striatum

Eriko Hieda, Miho Hamada, Takahide Shuto, Akinori Nishi
Dept.Pharmacol.Kurume Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 224-224, 2009.

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P2O-P4-3 Microglial proliferration mediated by P2Y2 receptors after kainate-induced neuronal injury

Yuya Tanaka, Kayoko Fujishita, Shuiti Koizumi
Dept.Pharmacol., Yamanashi Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 224-224, 2009.

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P2O-P4-4 Prenatal phencyclidine-treatment causes neurodevelopmental impairment, leading to long-lasting behavioral deficits

Kazuya Toriumi1, Akihiro Mouri1, Shiho Narusawa1, Yuki Aoyama1, Natsumi Ikawa1, Lingling Lu1, Taku Nagai2, Toshitaka Nabeshima1, 2
1Dept.Chem Pharmacol, Meijo Univ.Grad.Sch.Pharmaceutical Sci., 2Dept.Neuropsychopharmacol.and Hospital Pharmacy, Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 224-224, 2009.

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P2O-P4-5 Role of cannabinoid CB2 receptor upregulated in the spinal cord and dorsal root ganglion after nerve injury in anti-allodynic effect of CB2 agonist

Hiroshi Shimoyama, Makoto Tsuda, Keiko Tsukamoto, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue
Dept.Mol.Syst.Pharmacol., Grad.Sch.Pharm.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 225-225, 2009.

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P2O-P4-6 Toll-like receptor 4(TLR4), but not TLR3 or TLR9, KO mice have neuroprotective effects against focal cerebral ischemia in mice

Kana Hyakkoku1, Kazuhiro Tsuruma1, Masamitsu Shimazawa2, Hiroyuki Tanaka3, Satoshi Uematsu4, Shizuo Akira4, Hiroichi Nagai3, Hideaki Hara1
1De, Gifu Pharmaceut. Univ, 2Dept.Biofunct.Mol., Gifu Pharmaceut.Univ., 3Lab.Pharmacol., Dept.Bioactive Mol., Gifu Pharmaceut.Univ., 4Dept.Host Defense, Res.Inst.Microbial Dis., Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 225-225, 2009.

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P2O-P4-7 Phosphorylation of aquaporin-4 in the C-terminal domain regulates its intracellular trafficking

Ikuko Kadohira1, 2, Yoichiro Abe1, Mutsuo Nuriya1, Kazumi Sano1, Shoji Tsuji1, Takeshi Arimitsu1, Yasunori Yoshimura2, Masato Yasui1
1Dept.Pharmacol., keio Univ.Sch.Med., 2Dept.Obs & Gyn.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 225-225, 2009.

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P2O-P5-1 Granule cells of the dentate gyrus are not essential for antidepressant effects

Minoru Iijima, Hiroshi Nomura, Haruka Yamamoto, Daisuke Miyamoto, Norio Matsuki
Dept.Pharmacol, Tokyo Univ.Sch.Pha
Journal of Pharmacological Sciences 109 (suppl.2) 225-225, 2009.

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P2O-P5-2 Are Wistar Kyoto rats a genetic animal model of depression?-Behavioral and pharmacological evaluation-

Makiko Yamada1, Yukie Kawahara1, Fumi Kaneko1, Hirosi Kawahara2, Akinori Nishi1
1Dept.Pharmacol., Kurume Univ.Sch.Med., 2Dept.Dental Anesthesiology, Kyushu Dental College
Journal of Pharmacological Sciences 109 (suppl.2) 226-226, 2009.

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P2O-P5-3 Investigations of novel depression-related factors in a mouse model of learned helplessness

Salin Mingmalairak1, 2, Michihisa Tohda1, Yukihisa Murakami1, Ichiro Takasaki2, Yoshiaki Tabuchi2, Kinzo Matsumoto1
1Div.of Medicinal Pharmacology, Res.Inst.of Natl.Med., Univ.of Toyama, 2Div.of Mol.Gen.Res., Life Sci.Res.Cent., Univ.of Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 226-226, 2009.

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P2O-P5-4 Levetiracetam prevents the attention deficit induced by bilateral carotid artery occlusion in mice

Toshiyuki Himi, Maiko Kawaguchi, Kaoru Irie
Dept.Toxicology & Pharmacology
Journal of Pharmacological Sciences 109 (suppl.2) 226-226, 2009.

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P2O-P5-5 Antiepileptic and antiepileptogenic actions of levetiracetam in pentylenetetrazol-kindled mice

Yukihiro Ohno1, Shizuka Ishihara1, Nobumasa Sofue1, Saki Shimizu1, Junta Imaki1, Masashi Sasa2
1Lab.Pharmacol., Osaka Univ.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 226-226, 2009.

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P2O-P5-6 Comparison of the expression of p-glycoprotein between Epiletogenic Zone and tissue surrounding the Zone in refractory epileptic patients

Li Jian, Jiang De-Chun, Wang YuQin
Dept.Pharmacy, Xuan-wu hospital of Capital Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 227-227, 2009.

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P2O-P5-7 Influence of CYP2C19*2, CYP2C19*3 and CYP2C9*3 genotypes on anti-epileptic drugs resistance of refractory epileptics

Zhang Qingxia, Jiang DeChun, Wang YuQin
Dept.Pharmacy, Xuanwu Hospital of Capital Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 227-227, 2009.

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P2O-P5-8 The inhibitory effects of tropisetron on the c-fos protein expression by tropisetron in the rat brain

Shuntaro Kohnomi1, Katsuya Suemaru2, Mitsuhiro Gouda1, Kawasaki Hiromu1, Hiroaki Araki2
1Dept.Clinical Pharmaceutical Sci., Okayama Univ.Graduate Sch.Natural Sci.and Technology, 2Div.Clinical Pharmacol.and Pharmacy, Ehime Univ.Graduate Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 227-227, 2009.

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P2O-P6-1 Hepatic pharmacology research of the effective constituents(Shao Gan Duo Gan)from Peony and Licorice Decoction

Jun-ning Zhao, Jun Song, Xiao-Dong Wang, Zhi-Wen Deng, Ying Dai, Xiao-Hua Peng, Jin-Hai Yi
Institute of Pharmacology and Toxicology, Sichuan Academy of Chinese Medicine Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 227-227, 2009.

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P2O-P6-2 Effects of San'oshashinto on ischemia/reperfusion-induced cardiac dysfunction and serum lipid level in ovariectomized rats

Mayuko Sakanashi1, Makiko Sakanashi2, Katsuhiko Noguchi1, Toshihiro Matsuzaki1, Junko Nakasone1, Matao Sakanashi1
1Dept.Pharmacol., Sch.Med., Fac.Med., Univ.the Ryukyus, 2Dept.Anesth., Univ.the Ryukyus Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 228-228, 2009.

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P2O-P6-3 Inhibitory effect of piperlongumine on platelet aggregation via glycoprotein VI

Masaya Iwashita1, 2, Yuiko Nasu1, Masaki Saito1, 2, 3, Norimichi Nakahata1, 2, 3
1Dept.Cell.Signal., Grad.Sch.Pharmaceut.Sci., Tohoku Univ., 2Tohoku Univ.Int.Adv.Res.Edu.Org., 321st Century COE Program CRESCENDO, Grad.Sch.Pharmaceut.Sci., Tohoku Univ
Journal of Pharmacological Sciences 109 (suppl.2) 228-228, 2009.

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P2O-P6-4 Effect of novel dietary oil, green nuts oil, on plasma lipids

Mari Okimoto1, Yukiko Naito1, Shigehiro Tachibana1, Mami Furuya3, Toru Fukumitsu1, Tomoko Nagata2, Naoki Ohara1, 4
1Lab.Pharmacol., Hatano Research Institute, Food and Drug Safety Center, 2Lab.Pathol., Hatano Research Institute, Food and Drug Safety Center, 3Lab.toxicol.II, Hatano Research Institute, Food and Drug Safety Center, Lab.toxicol/II, Hatano Research Institute, Food and Drug Safety Center, 4Open Res.Center, Kinjyo Gakuin Univ
Journal of Pharmacological Sciences 109 (suppl.2) 228-228, 2009.

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P2O-P6-5 Ginsenoside metabolite IH 901 reduced foam cell formation in vitro

Jia Yi, Li Xiao-Hui
Dept.Pharm., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 228-228, 2009.

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P2O-P6-6 Preliminary molecular basis of Danggui-buxue-tang on Qi deficiency and blood stasis syndrome

Liu Ya, Li Xiao-Hui
Dept.Pharm., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 229-229, 2009.

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P2O-P6-7 Comparison of relaxant actions of tauroursodeoxycholic acid and related bile acids on the tracheal and vascular smooth muscle of rat

Toru Kawasuji, Takayuki Matsunaga, Toshiyuki Matsubara
Toyama Pref.Inst.for Pharm.Res
Journal of Pharmacological Sciences 109 (suppl.2) 229-229, 2009.

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P2O-P6-8 Research on anti-hypertension effect of several traditional Chinese medicines and spectrum-effect correlation of XJP

Suhong Chen1, Guiyuan Lv2, Xiaojun Gong2, Zhaohuan Lou2, Xinjian Yu2
1Wenzhou Medical College, 2Zhejiang Chinese Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 229-229, 2009.

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P2N-P7-1 Effects of short-tern insulin treatment on PDK1/Akt/eNOS pathway and endothelium-dependent relaxation in aortas from diabetic rats

Shingo Nemoto, Tsuneo Kobayashi, Kumiko Taguchi, Takayuki Matsumoto, Katsuo Kamata
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 229-229, 2009.

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P2N-P7-2 Measurement of nitric oxide in cultured endothelial cells by reversed phase HPLC with fluorescence detection using diaminofluorescein-FM

Yang-IL Fang, Hisayuki Ohata, Kazuo Honda
Dept.pharmacol., Sch.of Pharm.Sci., Showa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 230-230, 2009.

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P2N-P7-3 Molecular mechanism of antioxidant effects of Xyloketal B in endothelial cells

Chen Wen-Liang1, Meng Wei-Feng1, Pang Ji-Yan2, Lin Yong-Cheng2, Yuan Yong-Guan1, Liu Jie1, Wang Guan-Lei1
1Department of Pharmacology, Zhongshan School of Medicine, 2Department of Applied Chemistry and Department of Pharmacy, Sun Yat-Sen University
Journal of Pharmacological Sciences 109 (suppl.2) 230-230, 2009.

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P2N-P7-4 Salvianolic acid B protects endothelial cells from oxidant-mediated damage

Wu Hong-li, Li Xue-Jun
Department of Pharmacology, School of Basic Medical Sciences, Peking University
Journal of Pharmacological Sciences 109 (suppl.2) 230-230, 2009.

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P2N-P7-5 Inhibitory effects of beraprost sodium and limaprost alfadex, prostaglandins derivatives, on the human aorta endothelial cell injury induced by high concentration of glucose

Teruo Matsushita1, Ryusuke Tanaka1, Toshio Nakadate2
1Dept.Food Sci., Nat.Fish.Univ., 2Dept.Hygine, Sch.Med., Showa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 230-230, 2009.

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P2N-P7-6 Abnormalities of endothelium-dependent responses in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty(OLETF)rats are improved by chronic treatment with thromboxane synthase inhibitor

Eri Takaoka, Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 231-231, 2009.

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P2N-P7-7 Scutellarein, a potent preventer of diabetic complications

Banghao Zhu
Department of Pharmacology, Zhongshan Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 231-231, 2009.

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P2N-P8-1 Preventive effect of thrombin inhibitor argatroban on increased contractile response to thrombin in the basilar artery after subarachnoid hemorrhage

Katsuharu Kameda, Yuichiro Kikkawa, Mayumi Hirano, Katsuya Hirano
Div.Mol.Cardiol., Grad.Sch.Med.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 231-231, 2009.

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P2N-P8-2 Mechanical stretch potentiates angiotensin II-induced proliferation in spontaneously hypertensive rat vascular smooth muscle cells

Gang Liu1, Hirofumi Hitomi1, Naohisa Hosomi2, Daisuke Nakano1, Hideyasu Kiyomoto2, Shoji Kimura1, Masakazu Kohno2, Akira Nishiyama1
1Dept.Pharmacol., Kagawa Univ.Sch.Med., 2Dept.Internal Medicine, Kagawa Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 231-231, 2009.

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P2N-P8-3 Effect of sepiapterin in combination with methotrexate on endothelium-dependent relaxation of rat isolated aorta

Katsuhiko Noguchi1, Toshihiro Matsuzaki1, Naobumi Hamadate1, Mayuko Sakanashi1, Makiko Sakanashi2, Junko Nakasone1, Matao Sakanashi1
1Dept.Pharmacol., Sch.Med., Fac.Med., Univ.Ryukyus, 2Dept.Anesthesiol., Sch.Med., Fac.Med., Univ.Ryukyus
Journal of Pharmacological Sciences 109 (suppl.2) 232-232, 2009.

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P2N-P8-4 Angiotensin-(1-7)-induced vasodilatation in aortas is mediated by the AT2-receptor-dependent bradykinin generation

Katsutoshi Yayama, Tohru Tanabe, Hiroshi Okamoto
Dept.Cardiovascular Pharmacol., Kobe Gakuin University
Journal of Pharmacological Sciences 109 (suppl.2) 232-232, 2009.

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P2N-P8-5 Inhibitory effect of lomerizine, an anti-migraine drug, on serotonin-induced vasoconstriction of rat basilar artery

Shunsuke Kobayashi, Masakazu Ishii, Shunichi Shimizu, Yuji Kiuchi
Dept.Pathophysiol., Showa Univ.Sch.Pharm.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 232-232, 2009.

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P2N-P8-6 Cell motility of vascular smooth muscle cells exposed to the cigarette smoke components

Shinji Yoshiyama, Hong Hui Wang, Akio Nakamura, Kazuhiro Kohama
Dept.Mol.Cell.Pharmacol., Gunma Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 232-232, 2009.

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P2N-P8-7 The effect of stretch on gicerin expression and cell differentiation of vascular smooth muscle cells

Yukiko Kondo, Shinpei Ohtake, Kenzo Mizuma, Yasuyuki Irie, Eiichi Taira
Dept.Pharmacol., Iwate Medical Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 233-233, 2009.

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P2N-P8-8 Chronic production of peroxynitrite in the vascular wall is involved in impairment of vasorelaxation in SHR/NDmcr-cp rats, a model of metabolic syndrome

Satomi Kagota, Yukari Tada, Namie Nejime, Kazuki Nakamura, Masaru Kunitomo, Kazumasa Shinozuka
Dept.Pharmacol., Sch.Pharmacy and Pharmaceu.Sci., Mukogawa Women's Univ
Journal of Pharmacological Sciences 109 (suppl.2) 233-233, 2009.

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P2N-P9-1 Some affecting factors on the fatigue of the rat soleus muscle by electrical field stimulation

Masayuki Uchida1, Orie Mogami1, Masako Tsunematsu2
1Food Science Institute, Division of Research and Development, Meiji Dairies Corporation., 2Research and Development Center, Division of Research and Development, Meiji Dairies Corporation
Journal of Pharmacological Sciences 109 (suppl.2) 233-233, 2009.

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P2N-P9-2 Working mechanism of flubendiamide, a novel ryanodine receptor activator

Yuichi Sawaguchi1, Yusuke Mizuno1, Kenta Kato1, Shigeki Kiyonaka1, Emiko Mori1, Takao Masaki2, Hiroshi Takeshima3, Yasuo Mori1
1Dept.Synth.Chem.and Biol.Chem, Grad.Sch.Engineer., Kyoto Univ., 2Nihon Nohyaku Co., LTD., 3Dept.Biol.Chem, Grad.Sch.Pharm., Kyoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 233-233, 2009.

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P2N-P9-3 Myostatin antagonist, ActRIIB/Fc, transiently accelerates the clenbuterol-induced differentiation of C2C12

Akira Yamane1, Shuhei Kaneko2, Ryohei Iida2, Takeo Suga2, Mitsuhiko Morito2
1Dept.Biophysics, Tsurumi Univ.Sch.Dent.Med., 2Dept.Geriatirc Dent, Tsurumi Univ.Sch.Dent.Med
Journal of Pharmacological Sciences 109 (suppl.2) 234-234, 2009.

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P2N-P9-4 Sliding of F-actin on myosin II under the conditions fully saturated with variety of actin-binding proteins

Ryoki Ishikawa, Ayumi Takahashi, Akio Nakamura, Kazuhiro Kohama
Dept.Mol.Cell.Pharmacol., Gunma Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 234-234, 2009.

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P2N-P9-5 The analysis of calcium inhibition by constructing hybrid myosins between physarum and smooth muscle myosins

Ying Zhang1, Hozumi Kawamichi2, Akio Nakamura1, Laszlo Nyitray3, Kazuhiro Kohama1
1Dept.Mol.Cell.Pharmacol., Gunma Univ.Grad.Sch.Med., 2Dept.Mol.Physiol., Yamaguchi Univ.Sch.Med., 3Dept.Biochem., Eotvos Univ
Journal of Pharmacological Sciences 109 (suppl.2) 234-234, 2009.

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P2N-P9-6 Characterization of the Kinase-dead Mutants of Smooth Muscle Myosin Light Chain Kinase

Ce Xie1, Akio Nakamura1, Yue Zhang2, Ying Gao2, Ryoki Ishikawa1, Shinji Yoshiyama1, Kazufumi Kawano1, Kazuhiro Kohama1
1Dept.Pharmacol., Gunma Univ.Sch.Med., 2Dept.Biochemistry&Molecular Biology, DaLian Med
Journal of Pharmacological Sciences 109 (suppl.2) 234-234, 2009.

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P2N-P9-7 Altered role of C-type natriuretic peptide-activated pGC-cGMP signaling in streptozotocin-induced diabetic rat gastric smooth muscle

Xu Dong-Yuan1, Liu Lan2, Jin Zheng1
1Department of Physiology, 2Affiliated Hospital of Yanbian University
Journal of Pharmacological Sciences 109 (suppl.2) 235-235, 2009.

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P2N-P9-8 Biphasic tracheal relaxation induced by the extract from Nandina domestica Thunberg

Takuro Ueki1, 2, Tatsuhiro Akaishi1, Muneo Tsukiyama1, 3, Tsuneo Morioka2, Kazuho Abe1
1Lab.Pharmacol., Fac.Pharm., Musashino Univ., 2TOKIWA Pharmaceut, Co.Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 235-235, 2009.

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P2M-P10-1 Nitric oxide induced Ca2+ release via the ryanodine receptor

Toshiko Yamazawa1, Sho Kakizawa1, 2, Hideto Oyamada3, Takashi Murayama4, Katsuji Oguchi3, Takashi Sakurai4, Masamitsu Iino1
1Dept.Pharmacol., Grad.Sch.Med., The Univ.of Tokyo, 2Dept.Anat.& Neurobiol., Grad.Sch.Med., Nagasaki Univ., 3Dept.Pharmacol., Showa Univ.Sch.Med., 4Dept.Pharmacol., Juntendo Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 235-235, 2009.

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P2M-P10-2 Inhibitory effect of Jaks inhibitor AG490 on hydrogen peroxide-induced activation of TRPM2 channels

Yuko Kakihana1, Yuji Kaneko1, Tamio Hagiwara1, Masakazu Ishii1, Shinichiro Yamamoto2, Takashi Yoshida2, Toshihito Hiroi1, Yasuo Mori2, Yuji Kiuchi1, Shunichi Shimizu1
1Dept.Pathophysiol., Sch.Pharm.Sci., Showa Univ., 2Lab.Mol.Biol., Grad.Sch.Eng., Kyoto Univ., Kyoto University
Journal of Pharmacological Sciences 109 (suppl.2) 235-235, 2009.

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P2M-P10-3 Rho A and Rho kinase pathway regulates fibroblast contraction

Hiromi Nobe1, Koji Nobe2, Kazuo Honda2, Yukisato Ishida1, Yasushi Sakai1
1Dept.Physical Therapy, Bunkyo Gakuin Univ.Sch.Heal.Sci., 2Dept.Pharmacol., Showa Univ.Sch.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 236-236, 2009.

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P2M-P10-4 Cofilin is phosphorylated by cPKC in the degranulation from RBL-2H3 mast cells

Megumi Sakuma1, Yasuhito Shirai1, Maho Kuramasu1, Kenichi Yoshino1, Tomofumi Nakamura1, Izumi Hide2, Yoshihiro Nakata3, Naoaki Saito1
1Lab.of Mol.Pharmacol., Biosignal.Res.Ctr., Kobe Univ., 2Dept.Mol.Pharmacol.Neurosci.and Grad.Sch.Biomed.Sci., Hiroshima Univ., 3Dept.Pharmacol.Grad.Sch.Biomed.Sci., Hiroshima Univ
Journal of Pharmacological Sciences 109 (suppl.2) 236-236, 2009.

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P2M-P10-5 OxLDL stimulates lipoprotein-associated phospholipase A2 expression via the p38 MAPK and PPAR γ pathways in THP-1 monocytes

Wang Wenyi, Li Jie, Yang Ding, Wang Yiping
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 236-236, 2009.

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P2M-P10-6 Sulfhydryl-reducing agents prevent wortmannnin activitiy

Minoru Isosaki, Hitoshi Nakayama, Hiroyasu Satoh, Masanori Yoshizumi
Dept.Pharmacol., Nara Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 236-236, 2009.

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P2M-P10-7 α2-adrenoceptor mediated increases phosphorylation of MAP-2c in rat pheochromocytoma cells(PC12 cells)via a protein kinase C-and mitogen activated protein kinase-dependent mechanism

Tie Lu, Li Xue-Jun
Department of Pharmacology, School of Basic Medical Science, Peking University
Journal of Pharmacological Sciences 109 (suppl.2) 237-237, 2009.

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P2M-P10-8 Nitric oxide inhibits phosphorylation of neuronal nitric oxide synthase at Serine 1412

Tao Song1, 2, Yoshiaki Miyamotoa2, Toshie Kambe2, Yasuo Watanabe2
1China Med Univ, 1st Hasp, Dept Anes., 2Showa Pharmaceut Univ, Dept Pharmacol
Journal of Pharmacological Sciences 109 (suppl.2) 237-237, 2009.

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P2M-P11-1 Expression of NOX1/NADPH oxidase in mast cells

Masato Katsuyama1, Seisuke Tanigawa1, Satoshi Tanaka2, Mariko Sakanaka2, Chihiro Yabe-Nishimura1
1Dept.Pharmacol., Kyoto Pref.Univ.Med., 2Dept.Immunobiol., Sch.Pharm.Sci., Mukogawa Women's Univ
Journal of Pharmacological Sciences 109 (suppl.2) 237-237, 2009.

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P2M-P11-2 Effects on surface molecules on macrophages of extracellular HSPs induced by Polyporud Polysaccharide/Bacillus Calmette-Guerin from T24 human bladder cancer cell lin

Xing Zeng, Yu Huang, Jianan Wei, Ling Han, Dan Zhou
The Second Affiliated Hospital of Guangzhou University of TCM
Journal of Pharmacological Sciences 109 (suppl.2) 237-237, 2009.

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P2M-P11-3 Macrophage activation induced by the extract from Calotropis procera latex

Abdel Seddek1, 2, Motamed Mahmoud1, 3, Takahiko Shiina1, Hideki Nikami1, Tadashi Takewaki1, Yasutake Shimizu1
1Dept.Vet.Physiol., Gifu Univ., 2Dep.Toxi., Fac.Vet.Med., South Valley Univ., 3Dep.Physiol., Fac.Vet.Med., Sohaj Univ
Journal of Pharmacological Sciences 109 (suppl.2) 238-238, 2009.

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P2M-P11-4 Evaluation of neutrophilic airway inflammation in mice treated with toll-like receptor(TLR)ligands using a rapid cytometric method

Takashi Sakata1, Yoji Nagira2, Yuya Ezaki2, Yu Kajiwara2, Takeshi Murata2, Hiroyuki Tanaka2, Naoki Inagaki2, Hiroichi Nagai2
1Sci.Inst.Bussiness Div., SYSMEX CORPORATION, 2Lab Pharmacol, Dept Bioactive Mol, Gifu Pharm Univ
Journal of Pharmacological Sciences 109 (suppl.2) 238-238, 2009.

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P2M-P11-5 Involvement of TRPM2 channels in the early vascular permeability induced by acetic acid and zymosan

Yuji Kaneko1, Yuko Kakihana1, Toshihito Hiroi1, Takaharu Negoro2, Disuke Kamei3, Masakazu Ishii1, Yuji Kiuchi1, Yasuo Mori1, Shunichi Shimizu3
1Dept.Pathophysiol., Showa Univ.Sch.pharm.Sci., 2Dept.Genetic Analysis., Showa Univ.Sch.pharm.Sci., 3Dept.Res.Devel.Innovative Medical Needs., Showa Univ.Sch.pharm.Sci., 4Lab.Mol.Biol., Sch.Engineer., Kyoto Univ., Kyoto University
Journal of Pharmacological Sciences 109 (suppl.2) 238-238, 2009.

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P2M-P11-6 Inhibitory effects of a novel adhesion molecule antagonist, T-594 on allergic rhinitis in guinea pigs

Yoko Koga, Hiroyuki Meguro, Mie Kainoh
Pharm.Res.Lab., Toray
Journal of Pharmacological Sciences 109 (suppl.2) 238-238, 2009.

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P2M-P11-7 Effects of Cyclosporin A on the development of macrophages from BMPCs in vitro

Shen Hong1, 2, Zhao Yong2, Wu Guojuan1
1Department of Veterinary Medicine & Animal Science, Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, 2State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 239-239, 2009.

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P2M-P11-8 Anti-inflammatory effect of a novel artemisinin derivative SM905

Wei Tang, Jun-xia Wang
Lab of Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 239-239, 2009.

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P2M-P12-1 PI3kinase signalling is more important than p38MAPkinase signalling for steroid-resistant airway inflammation in a cigarette smoking murine model

Yasuo Kizawa1, Yuji Watanabe1, Shoichi Eto1, Genki Kimura1, Ryoko Saito1, Kazuhiro Ito2, Peter J.Barnes2, Tadashi Kusama1
1Dept.Physiol.& Anat., Nihon Univ.Coll.Pharmacy, 2Airway Disease Sec., NHLI, Imperial Coll
Journal of Pharmacological Sciences 109 (suppl.2) 239-239, 2009.

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P2M-P12-2 Effects of clarithromycin in cigarette smoke-exposed guinea pig model

Jun-ichi Fuchikami1, Maki Takahashi1, Yukiko Ozeki1, Uina Fukuda1, Katsuyuki Takahashi1, Yasuki Akie1, Toshihito Kadota1, Hachiro Seno2, Shingo Kano3
1Sugi Institute of Biological Science Co., Ltd, 2Office for University-Industry Collaboration, Osaka Univ., 3Aphoenix, Inc
Journal of Pharmacological Sciences 109 (suppl.2) 239-239, 2009.

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P2M-P12-3 Effects of diazepam on chemoreceptor reflex in rats exposed to chronic intermittent hypoxia

Masahiko Suzuki1, Masami Nishina2, Shinichi Nakamura3, Naomi Takehara1
1Lab.Phamacol., Sch.Med.Tech.and Health, Fac.Health.and Med.Care, Saitama Med.Univ., 2Med.Res.Center, Fac.Med., Saitama Med.Univ., 2Depts.Anesth., Fac.Med., Saitama Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 240-240, 2009.

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P2M-P12-4 Y-27632 augments the isoflurane-induced relaxation of bronchial smooth muscle in rats

Motohiko Hanazaki1, Yoshihiko Chiba3, Masataka Yokoyama1, Kiyoshi Morita1, Atsushi Kohjitani2, Hiroyasu Sakai3, Miwa Misawa3
1Dept.Anesthesiol., Okayama Univ.Med.Sch., 2Deprt.Dental Anesthesiol, Kagoshima Univ., 3Dept.Pharmacol.Sch.Pharmacy, Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 240-240, 2009.

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P2M-P12-5 Possibility of simply experimental model of cough reflex:Carina stimulation with lipopolysaccharide on citric acid

Motomu Tanaka, Takaaki Senbonmatsu, Kei Maruyama
Dept.Pharmacol.Saitama Med.Univ.Med
Journal of Pharmacological Sciences 109 (suppl.2) 240-240, 2009.

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P2M-P12-6 Contrasting Effects of IL-1β between porcine and bovine tracheal smooth muscle contraction with acetylcholine

Tsuyoshi Tajima, Munenori Harada, Takahiro Kimijima, Takeharu Kaneda, Norimoto Urakawa, Kazumasa Shimizu
Div.Vet.Pharmacol., Nippon Vet.Life Sci.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 240-240, 2009.

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P2M-P12-7 Investigation of increase in nasal mucosa vascular permeability in rats as experimental allergic rhinitis model

Susumu Kyoku, Mayumi Obo, Hiromi Iizuka, Yasushi Yamashita
Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 241-241, 2009.

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P2L-P13-1 Introduction and educational effectiveness of the multimedia medical and dental simulation material on the pharmacological practice

Keiichi Ohya1, Yukihiko Tamura1, Mariko Takahashi1, Atsuhiro Kinoshita2
1Sec.Pharmacol.Dept.Hard Tiss.Engineering, Graduate School, Tokyo Med.Dent.Univ., 2Preventive Oral Health Care, Sch.Oral Health, Fac.Dent., Tokyo Med.Dent.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 241-241, 2009.

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P2L-P13-2 Calcimimetics(cinacalcet HCI)suppress aortic and heart calcification in uremic rats

Nobuo Nagano, Takehisa Kawata, Masaki Obi, Sonoe Miyata, Chika Koyama, Sachiko Wakita, Nami Kobayashi, Michihito Wada
Pharmacol.Res.Labs., Kyowa Hakko Kirin Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 241-241, 2009.

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P2L-P13-3 3-dimensional observation of the trabecular bone microarchitecture in OVX-induced osteoporotic rats by micro-computed tomography

Noboru Kuboyama1, Yoshimitsu Abiko2
1Dept.of Oral Mol.Pharmacol., Nihon Univ.Sch.Dent.at Matsudo, 2Dept.of Bioche.and Mol.Biol., Nihon Univ.Sch.Dent.at Matsudo
Journal of Pharmacological Sciences 109 (suppl.2) 241-241, 2009.

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P2L-P13-4 Gene expression and ossification deficiency of spontaneous cartilage calcification-insufficient(CCI)rats

Masami Tanaka1, 2, Izuru Yokomi2, 5, Minoru Watanabe2, Katsuko Sudo3, Hitoshi Satoh4, Tsuneo Igarashi5, Azusa Seki6, Shinichi Kobayashi2
1Inst.Animal Exp., St.Marianna Univ.Grad.Sch.Med., 2Dept.Pharmacol., St.Marianna Univ.Sch.Med., 3Animal Res.Center, Tokyo Med.Univ., 4Lab.Tumor Cell Biol., Grad.Sch.Frontier Sciences, Univ.Tokyo, 5Animal Care Co., Ltd., 6Hamri Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 242-242, 2009.

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P2L-P13-5 The control release of TNF-α is necessary to mimic the LPS-induced bone resorption on calvaria

Kenichi Nagano1, Kazuhiro Aoki1, Hussain Mian1, Neil Alles1, Asako Shimoda2, Nobuyuki Morimoto2, Kazunari Akiyoshi2, Keiichi Ohya1
1Dept.Hard Tissue Engineering(Pharmacology), Graduate School, Tokyo Medical & Dental Univ., 2Dept.Organic Materials, IBB, Tokyo Medical & Dental Univ
Journal of Pharmacological Sciences 109 (suppl.2) 242-242, 2009.

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P2L-P13-6 Effects of immunosuppressant, tacrolimus treatment on bone metabolism in rat

Junkichi Kanda1, Atsushi Takahashi2, Eriko Katayanagi1, Kenji Onodera3, Hiroyuki Wakabayashi1
1Dept.Clin.Pharmacother., Niigata Univ.Pharm.Appli.Life.Sci., 2Clin.Dent.for Disabled, Tohoku Univ.Dent.Hosp., 3Lab.Pharmacother.Yokohama Col.Pharm
Journal of Pharmacological Sciences 109 (suppl.2) 242-242, 2009.

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P2L-P13-7 Genetic difference based on the classification of the ossification of the posterior longitudinal ligament of the cervical spine

Hitoshi Kudo1, 2, Sunao Tanaka1, 2, Takuya Numasawa2, Atsushi Ono2, Kanichiro Wada2, Toru Asari1, 2, Kazuhiko Seya1, Izumi Miki1, Satoshi Toh2, Shigeru Motomura1, Ken-Ichi Furukawa1
1Dept.Pharmacol., Hirosaki Univ.Grad.Sch.Med., 2Dept.Ortho.Surg., Hirosaki Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 242-242, 2009.

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P2L-P13-8 Differences in expression of CLCA isoforms in rat salivary gland tissue may be related to the subcellular localization and function of integrins

Jun Yamazaki1, Kazuhiko Okamura2, Kenji Kitamura1
1Dept.of Physiol.Sci.& Mol.Biol., Fukuoka Dent.Coll., 2Dept.of Morphol.Biol., Fukuoka Dent.Coll
Journal of Pharmacological Sciences 109 (suppl.2) 243-243, 2009.

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P2L-P14-1 A study of Candida albicans subtypes and antifungal agent susceptibility in the 287 clinical isolates from Oral Candidasis

Tomohiro Nagayama1, Yoshiaki Kamikawa2, Tomoaki Sato1, Kazumasa Sugihara2
1Dept.Appl.Pharmacol., Grad.Sch.Med.& Dent.Sci. Kagoshima Univ., 2Dept.Maxillofac.Diag.& Surg.Sci.Grad.Sch.Med.& Dent.Sci.Kagoshima Univ
Journal of Pharmacological Sciences 109 (suppl.2) 243-243, 2009.

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P2L-P14-2 Effect of Ganoderma lucidum polysaccharide on heme oxygenase-1 expression and activity in BCG-induced immune hepatic injury in rats

Xin Wang, Xuan Zhao, Dan Li, Zhi-bin Lin, Guo-liang Zhang
Department of pharmacology, Basic medical school, Peking University Health Science Center
Journal of Pharmacological Sciences 109 (suppl.2) 243-243, 2009.

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P2L-P14-3 Oligonol preconditioning induces neuroprotection via upregulation of EAAT3 activity in LPS stimulated C6 cells

Xiaohong Zhang
Laboratory of Biochemistry, Amino UP Chemical Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 243-243, 2009.

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P2L-P14-4 Minocycline attenuates poly I:C-induced immunological fatigue-like behavior via suppression of inflammatory cytokines expression in the brain

Masanori Yamato1, 2, Kaori Okuyama1, Guanghua Jin1, Asami Eguchi1, Yosky Kataoka1, 2, Yasuyoshi Watanabe1, 2
1Dept.Physiol., Osaka City Univ Grad Sch Med, 2Center for Molecular Imaging Science, RIKEN
Journal of Pharmacological Sciences 109 (suppl.2) 244-244, 2009.

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P2L-P14-5 A study on the characteristics of SHV-11V beta-lactamase from Enterobacter cloacae resistant to ceftazidime

Gang Liu, Yun Zeng, Li Lin, Yong-en Xie, Bao-dong Ling
Institute of Materia Medica and Department of Pharmacology, North Sichuan Medical College, Institute of Materia Medica and Department of Pharmacology, North Sichuan Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 244-244, 2009.

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P2L-P14-6 Disposition and metabolism of tribendimidine in Chinese human

Ruichen Guo, Guiyan Yuan, Benjie Wang, Chunmin Wei, Rui Zhang
Institute of clinical pharmacology/Qilu hospital of Shandong university
Journal of Pharmacological Sciences 109 (suppl.2) 244-244, 2009.

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P2L-P15-1 Administration of ouabain aggravates neuromuscular paralysis associated with botulism

Ryu Fujikawa1, Toshihiro Unno2, Seiichi Komori2, Toshiaki Ishii3
1Dept.Pathobiol., Unit.Grad.Sch.Vet.Sci., Gifu Univ., 2Lab.Pharmacol., Dept.Vet.Med., Gifu Univ., 3Dept.Pathobiol., Obihiro Univ.Sch.Vet
Journal of Pharmacological Sciences 109 (suppl.2) 244-244, 2009.

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P2L-P15-2 Role of norepinephrine overflow in post-ischemic cardiac dysfunction of isolated rat heart

Taiki Fukumoto1, Naoto Yamashita1, Masashi Tawa2, Mamoru Ohkita1, Yasuo Matsumura1
1Lab.Pathol.and Mol.Pharmacol., Osaka Univ.Pharmaceut.Sci., 2Dept.Pharmacol., Shiga Univ.Med.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 245-245, 2009.

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P2L-P15-3 Pioglitazone(PIO)improves abnormal distribution of mesenteric perivascular nerves in fructose drinking rats(FDR)

Keisuke Amitani1, Yoshito Zamami1, Miho Hosoda1, Mitsuhiro Goda1, Yoshihisa Kitamura1, 2, Hiromu Kawasaki1
1Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ, 2Dept.Pharmac.Care Hlth.Sci., Grad.Sch.Med.Den.Pharmac.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 245-245, 2009.

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P2L-P15-4 Distribution and characterization of perivascular nerves in neovasculatures of mouse corneal

Akiko Matsuyama, Yoko Sone, Mitsuhiro Goda, Hiromu Kawasaki
Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ
Journal of Pharmacological Sciences 109 (suppl.2) 245-245, 2009.

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P2L-P15-5 Effects of Ca2+/calmodulin dependent protein kinase II inhibitors on catecholamine secretion in bovine adrenal chromaffin cells

Haruhiro Kuwashima, Shin Soma, Tomohiko Kimura
Dept.Pharmacol., The Nippon Dent.Univ.Sch.Life Dentist.at Niigata
Journal of Pharmacological Sciences 109 (suppl.2) 245-245, 2009.

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P2L-P15-6 Simvastatin, an HMG-CoA reductase inhibitor, inhibits the catecholamine secretion and synthesis through suppression of ion influx in bovine adrenal medullary cells

Yumiko Toyohira, Taeko Matsuda, Hideaki Itoh, Susumu Ueno, Masato Tsutsui, Nobuyuki Yanagihara
Dept.Pharmacol., Univ.Occup.& Environ.Hlth., Japan, Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 246-246, 2009.

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P2L-P15-7 Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

Daisuke Kozai1, Nobuaki Takahashi1, Yusuke Mizuno1, Shinichiro Yamamoto1, Shigeki Kiyonaka1, Takahiro Shibata2, Koji Uchida2, Yasuo Mori1
1Dept.Synth.Chem.and Biol.Chem., Grad.Sch.Engineer., Kyoto Univ., 2Dept.Appl.Mol.Biosci., Grad.Sch.Bioagri.Sci., Nagoya Univ
Journal of Pharmacological Sciences 109 (suppl.2) 246-246, 2009.

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P2L-P15-8 Possible involvement of IP3-induced Ca2+ release(IICR)-mediated BK channel opening in the prostanoid TP receptor-mediated inhibition of noradrenaline release from the rat stomach

Kumiko Nakamura, Kunihiko Yokotani
Dept.of Pharmacol., Sch.of Medicine, Kochi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 246-246, 2009.

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P2L-P16-1 Effect of aging on insulin resistance and endothelial function in PHT rabbit

Yoshimi Shimizu1, Yuko Igarashi1, Naoki Fukuda3, Tsunekata Ito3, Akira Ishihata2, Yumi Katano1
1Div.Theoretic.Nurs.& Pathophysiol, Yamagata Univ.Sch.Med., 2Div.Pathophysiol, Ohu Univ.Sch.Pharmaceutical Sci., 3Lab.Animal Ctr, Yamagata Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 246-246, 2009.

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P2L-P16-2 Alterations in lipid metabolism associated with atherosclerosis progression

Mayumi Mori1, Mayuko Morita2, 3, Hiroki Nakanishi2, 3, Hiromi Tsushima4, Toyohiro Tada5, Jin-ichi Ito6, Ryo Taguchi2, 3
1Dept.Pharmacol., Nagoya City Univ., Grad.Sch.Med.Sci., 2Dept.Metabolome, Grad.Sch.Med., Tokyo Univ., 3CREST, 4Coll.Pharm., Kinjo Gakuin Univ., 5Dept.Pathol., Nagoya City Univ.Sch.Nurs., 6Dept.Biochem., Nagoya City Univ., Grad.Sch.Med.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 247-247, 2009.

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P2L-P16-3 Gender differences in age-related endothelial function in the murine aorta

Yasuhiro Takenouchi, Tsuneo Kobayashi, Takayuki Matsumoto, Katsuo Kamata
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 247-247, 2009.

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P2L-P16-4 The studies of Ziziphi Spinosae Decoction(ZSD)intervention to old rats syndrome model with Yin and blood-deficiency and sleep deprivation

Qiuyun You, Ping Wang
Hubei college of traditional Chinese medicine
Journal of Pharmacological Sciences 109 (suppl.2) 247-247, 2009.

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P2L-P16-5 Effects of anticholinergic agents on the atropine-resistant contraction of aged rat bladders

Tomoka Hosoda1, Akiko Yamada1, Yuko Kobayashi1, Yoshimi Shimizu1, Akira Ishihata2, Yumi Katano1
1Div.Theoretic.Nurs.& Pathophysiol, Yamagata Univ.Sch.Med., 2Div.Pathophysiol, Ohu Univ.Sch.Pharmaceutical Sci
Journal of Pharmacological Sciences 109 (suppl.2) 247-247, 2009.

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P2L-P16-6 Effects of Dendrobium polysaccharides on the learning and memory deficits and resisting senility in aging mice induced by D-galactose

Wang Ling-yi, Huang Bin, Shi Jingshan
Department of Pharmacology, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 248-248, 2009.

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P2L-P16-7 Effect of Liuwei and Bawei Dihuang decoctions on protein expressions in senescence-accelerated mouse

Wenxia Zhou, Ning Jiang, Lei Dong, Shan Wang, Yongxiang Zhang
Beijing Institute of Pharmacology and Toxicology
Journal of Pharmacological Sciences 109 (suppl.2) 248-248, 2009.

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P2L-P17-1 Functional analysis of choline transporter in human placental choriocarcinoma BeWo cells

Hirohisa Tajima1, Shizuka Tsukagoshi1, Tomoko Yamada1, Masato Inazu1, 2, Teruhiko Matsumiya1, 2
1Dept.Pharmacol., Tokyo Med.Univ., 2Dept.Prevent.Med., Tokyo Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 248-248, 2009.

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P2L-P17-2 Effect of intrauterine injection of adrenomedullin antisense oligonucleotide during gestation in rats

Kazuhiko Shibata, Tetsuji Yae, Hidenori Sagara
Dept.Pharmaceutical Information Sci., Matsuyama Univ
Journal of Pharmacological Sciences 109 (suppl.2) 248-248, 2009.

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P2L-P17-3 The study of mixture uniform design and the proportion of Release Dysmenorrhea Injection

RiYue Yu, XianQin Wang, Juan Tan, Yan Hong
Dept.Pharmacol., JiangXi Traditionary Chinese Medicine Univ
Journal of Pharmacological Sciences 109 (suppl.2) 249-249, 2009.

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P2L-P17-4 Cyclic AMP signaling through exchange protein directly activated by cyclic AMP(Epac)in human placenta

Kei Kaneyama1, Mikihiro Yoshie1, Keiichi Isaka2, Masahiko Kutsukake1, Kazuhiro Tamura1
1Dept.Endocrine Pharmacol., Tokyo Univ.Pharm & Life Sci., 2Dept.Obstet & Gynecol., Tokyo Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 249-249, 2009.

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P2L-P17-5 Functional roles of voltage-gated Na+ channels, Nav1.6, in murine vas deferens myocytes

Hai-Lei Zhu1, Tetsuichiro Inai2, Masatoshi Nomura3, Noriyoshi Teramoto1
1Dept.Pharmacol., Kyushu Univ.Grad.Sch.Medical Sciences, 2Dept.Developmental Molecular Anatomy., Kyushuu Univ.Grad.Sch.Medical Sciences, 3Dept.Med Bioregulatory Sci., Kyushuu Univ.Grad.Sch.Medical Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 249-249, 2009.

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P2L-P17-6 Evaluation of intravesical pressure and urinary function in a newly introduced cystitis model in female dogs

Yasuo Nakamura, Kazuaki Sasaki, Hiroizumi Yamanaka, Ryouji Mizumachi, Masakazu Imaizumi, Hiroshi Atai, Katuhide Nishi
MITSUBISHI CHEMICAL SAFETY INSTITUETE LTD
Journal of Pharmacological Sciences 109 (suppl.2) 249-249, 2009.

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P3O-A1-1 Involvement of Src in tyrosine phosphorylation of occludin and disruption of the blood-brain barrier after transient focal cerebral ischemia

Kazutoshi Murotomi, Norio Takagi, Yuji Takenaga, Satoshi Takeo, Kouichi Tanonaka
Dept.Mol.Cell.Pharmacol., Tokyo Univ.Pharm.Life Sci
Journal of Pharmacological Sciences 109 (suppl.2) 250-250, 2009.

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P3O-A1-2 Effects of compound danshen tablets on cognitive and exploratory functions and brain-hypoxia in mice of cerebral ischemia reperfusion

Dan-Shen Zhang1, Guan-Hua Du2, Li Zhang1, Gui-Ping Xue1, Hong-Na Huang1, Xiao-Xia Zheng1
1Dept.Pharmacol., Hebei North University, 2Institute of Materia Medica, Chinese Academy of Medical Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 250-250, 2009.

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P3O-A1-3 Protective effects of gastrodine on focal cerebral ischemia-reperfusional injury in rats

Nie Jing1, 2, Du Liang2, Li Shu-jun2
1Department of Pharmacology, 2Key Laboratory of Basic Pharmacology of Guizhou, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 250-250, 2009.

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P3O-A1-4 [6]-gingerol reduces cerebral ischemia/reperfusion injury in the hippocampus of rats via regulation of SGK1/GSK-3beta pathway

Cai Fei, Li Cairong, Wu Jiliang, Ouyang Changhan, Zheng Min
Department of Pharmacology, Medical College, Xianning University
Journal of Pharmacological Sciences 109 (suppl.2) 250-250, 2009.

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P3O-A1-5 Effects of hypothermia in MCAO mice

Akihito Ito, Mikito Kikumori, Hiroyuki Abe, Shigenori Furukawa
NISSEI BILLS Co., Ltd., Shiga Laboratory
Journal of Pharmacological Sciences 109 (suppl.2) 251-251, 2009.

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P3O-A1-6 Enriched environment improves chronic cerebral hypoperfusion-infuced spatial cognitive deficit in mice:Involvement of VEGF and BDNF

Qi Zhao1, Kinzo Matsumoto1, Miki Hayashida1, Koichi Tsuneyama2
1Div.Medicinal Pharmacol., Inst.Natural Med., Univ.Toyama, 2Dept.Diagnostic Pathol., Grad.Sch.Med.Pharm.Sci., Univ.Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 251-251, 2009.

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P3O-A1-7 Oncostatin M induces functional and structural impairment of blood-brain barriers comprised of rat brain capillary endothelial cells

Tomoya Wakigawa, Fuyuko Takata, Shinya Dohgu, Eriko Harada, Kousuke Matumoto, Takasi Obara, Yasufumi Kataoka
Dept.Pharm.Care.Health Sci., Fac.Pharm.Sci., Fukuoka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 251-251, 2009.

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P3O-A2-1 Effects of high-fat diet on body temperature regulatory system in rats

Hiromi Tsushima1, Kazuyo Yamada2, Harumi Okuyama2, Yoko Hashimoto3, Mayumi Mori4, Kakeshi Ohkubo5, Hidehiko Hibino5
1Lab.of Pharmacol., College of Pharm., Kinjo Gakuin Univ., 2ORC, Kinjo Gakuin Univ., 3Dep.of Biochem., Sch.of Dentistry, Aichi-Gakuin Univ., 4Dep.of Pharmacol.Nagoya City Univ.Med.Sch., 5NOF Corporation
Journal of Pharmacological Sciences 109 (suppl.2) 251-251, 2009.

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P3O-A2-2 Influence of noxious lingual stimulation on excitability of face primary motor cortex(face MI)in rats

Kazunori Adachi1, 2, Greg.M.Murray3, Jason.-C.Lee4, Barry.J.Sessle4, Hiroshi Sakagami1, Noriaki Koshikawa2
1Div.Pharmacol., Meikai Univ.Dent., 2Dept.Pharmacol.Nihon Univ.Sch.Dent., 3Fac.Dent.Jaw Funct.Orofacial Pain Res.Unit.Westmead Hospital.Univ.Sydney, 4Dept.Physiol.Univ.Toronto Fac.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 252-252, 2009.

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P3O-A2-3 Polysialic acid regulates the initiation of neuronal migration in postnatal hippocampus

Mari Sajo, Norio Matsuki, Ryuta Koyama
Lab.Chem.Pharmacol., Grad.Sch.Pharm.Sci., The Univ.Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 252-252, 2009.

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P3O-A2-4 Monitoring neuronal activity in a closed ACSF-circulation recording chamber

Mika Mizunuma, Norio Matsuki, Yuji Ikegaya
Lab.Chem.Pharmacol., Grad.Sch.Pharmaceut.Sci., Univ.Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 252-252, 2009.

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P3O-A2-5 FK1706, non-immunosuppressant neurophilin ligand, ameliorates functional outcome following spinal cord injury through its neuroregenerative action

Takayuki Yamaji, Shunji Yamazaki, Jiyao Li, Raymond Price, Nobuya Matsuoka, Seitaro Mutoh
Pharmacol.Res.Labs., Astellas Pharma Inc
Journal of Pharmacological Sciences 109 (suppl.2) 252-252, 2009.

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P3O-A2-6 Endothelins elongate coritcal neurites of rat

Rieko Muramatsu1, 2, Noriko Uesugi1, Toshihide Yamashita1
1Dept.Mol.Neurosci., Osaka Univ.Sch Med, 2Mol.Res.Center Child.Mental Dev., Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 253-253, 2009.

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P3O-A2-7 Enhanced expression of RNase L during neuronal damage in mouse brain

Chie Sugiyama, Ayumi Tani, Satoshi Komatubara, Kiyokazu Ogita
Dept.Pharmacol., Setsunan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 253-253, 2009.

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P3O-A2-8 Neuroprotection by polyamine derivatives via inhibition of N-methyl-D-aspartate receptors

Takashi Masuko1, Eri Namiki1, Yuta Nemoto1, Muneharu Miyake2, Kuniko Kusama-Eguchi3, Yasuo Kizawa1, Keiko Kashiwagi4, Kazuei Igarashi5, Tadashi Kusama1
1Research Unit Physiol.and Anat., Nihon Univ.Coll.Pharm., 2Research Unit Org.Chem., Nihon Univ.Coll.Pharm., 3Research Unit Mol.Cell.Biol., Nihon Univ.Coll.Pharm., 4Dept.Clin.Biochem., Fac.Pharm.Chiba Inst.Sci., 5Dept.Clin.Biochem., Grad.Sch.Pharm.Sci.Chiba Univ
Journal of Pharmacological Sciences 109 (suppl.2) 253-253, 2009.

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P3O-A3-1 Dysfunction of GABAergic transmission of rat harboring S284L Chrna4 mutation

Shinya Ueno1, Keisuke Migita1, Junko Yamada1, Shukuko Yoshida2, Gang Zhu2, Fumiaki Mori3, Kouichi Wakabayashi3, Motohiro Okada4, Shinichi Hirose5, Sunao Kaneko2
1Dept Neurophysiol., Hirosaki Univ.Grad.Sch.Med., 2Dept.Neuropsychiatry, Hirosaki Univ.Grad.Sch Med, 3Dept.Neuropathology, Hirosaki Univ.Grad.Sch Med, 4Dept Psychiatry, Mie Univ Graduate Scl of Med., 5Dept Pediatrics, Fukuoka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 253-253, 2009.

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P3O-A3-2 GABAA receptors partially mediate propofol-induced spatial learning and memory dysfunction in the ventral hippocampus of rats

Yuan Liyong1, Dai Tijun2, Yang Jianping3
1Ningbo Women and Children's Hospital, 2Xuzhou Medical College, 3The 1st Affiliated Hospital of Soochow University
Journal of Pharmacological Sciences 109 (suppl.2) 254-254, 2009.

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P3O-A3-3 Comparative study of GABAergic and dopaminergic neurons in planarian Dugesia japonica

Kaneyasu Nishimura1, Yoshihisa Kitamura2, Takashi Taniguchi2, Kiyokazu Agata1
1Dept.Biophys., Grad.Sch.Sci., Kyoto Univ., 2Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 254-254, 2009.

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P3O-A3-4 Eicosapentaenoic acid inhibits interleukin-6 production in interleukin-1β-stimulated C6 glioma cells through peroxisome proliferator-activated receptor-gamma

Akiko Kawashima, Tsuyoshi Harada, Satoshi Kajikawa, Ryo Saito, Takashi Yano, Kazunori Imada, Kiyoshi Mizuguchi
Development Research, Mochida Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 254-254, 2009.

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P3O-A3-5 Mitochondrial calcium permeability in NMDA neurotoxicity

Yuki Kambe, Noritaka Nakamichi, Hideo Taniura, Yukio Yoneda
Lab.Mol.Pharmacol., Kanazawa Univ.Grad.Sch.Nat.Sci.Tech
Journal of Pharmacological Sciences 109 (suppl.2) 254-254, 2009.

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P3O-A3-6 Sensitivity to NMDA in granule cells newly generated after neuronal damage in the hippocampal dentate gyrus

Koichi Kawada, Yukiko Ikeda, Megumi Adachi, Shohei Sano, Masanori Yoneyama, Kiyokazu Ogita
Dept.Pharmacol., Setsunan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 255-255, 2009.

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P3O-A3-7 Role of PLC in the centrally administered NMDA-induced adrenomedullary outflow in rats

Shoshiro Okada, Naoko Yamaguchi
Dept.Pharmacol., Kochi Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 255-255, 2009.

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P3O-A4-1 Identification and distribution of tyramine β-hydroxylase-positive neurons in planarian Dugesia japonica

Jun Tsushima1, Yoshihisa Kitamura1, Kaneyasu Nishimura2, Kanji Yoshimoto3, Takashi Taniguchi1, Kiyokazu Agata2
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2Dept.Biophys., Grad.Sch.Sci., Kyoto Univ., 3Dept.Legal Med., Kyoto Pref.Univ.Med
Journal of Pharmacological Sciences 109 (suppl.2) 255-255, 2009.

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P3O-A4-2 In vivo fluorescent imaging of glutamate in sensory cortex

Hiroshi Sekiya1, Shigeyuki Namiki2, Hirokazu Sakamoto2, Sho Iinuma2, Kenzo Hirose2, 3, Masamitsu Iino1
1Dept.Pharmacol., Univ.Tokyo Grad.Sch.Med., 2Dept.Cell PHysiol., Nagoya Univ.Sch.Med., 3Dept.Neurobiol., Univ.Tokyo Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 255-255, 2009.

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P3O-A4-3 Simultaneous measurement of endogenous release of monoamines from brain slices in histamine receptors deficient mice

Dongying Zhang, Eiko Sakurai, Naoko Takino, Kazuhiko Yanai
Dept.Pharmacol., Tohoku Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 256-256, 2009.

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P3O-A4-4 The evaluation of the psychotropic drugs using new behavioral parameters

Takatoshi Komiya1, Satoshi Kuchiiwa2, Toshiko Kuchiiwa3, Abudureheman Abuduaini2, Osamu Murakami4, Shiro Mori5, Takuya Kuchiiwa6, Yasuo Takeda1, 7, Katsushi Yamada1, 7
1Dep.Clin.Pharm.and Pharmacol., Grad.Sch.Med.Dent.Sci., Kagoshima Univ, 2Dept.Neuroanat.Grad.Sch.Med.Dent.Sci.Kagoshima Univ., 3Dept.Child Stud.Fac.Internat.Human Stud.Kagoshima Immaculate Heart Univ., 4Muromachi Kikai Co., Ltd., 5Dept.Physical Ed.National Inst.of Fitness and Sports in Kanoya, 6Dept.Chem.Fac.Sci.Biosci.Kagoshima Univ., 7Dep.Clin.Pharm., Kagoshima Univ.Hosp
Journal of Pharmacological Sciences 109 (suppl.2) 256-256, 2009.

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P3O-A4-5 ADP activates microglial migration and phagocytosis via Gi-coupled P2Y receptor

Chizuru Tsuzuki, Hiroshi Hibino, Yoshihisa Kurachi
Dept.Pharmacol., Grad.Sch.Med., Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 256-256, 2009.

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P3O-A4-6 Correlation of metabotropic glutamate receptor 1(mGluR1)receptor occupancy with In vivo activity of allosteric mGluR1 antagonists

Gentaroh Suzuki1, 2, Hiroko Kawagoe-Takaki1, Takao Inoue1, Toshifumi Kimura1, Hirohiko Hikichi1, Takashi Murai1, Akio Satow1, Mikiko Hata1, Shunsuke Maehara1, Satoru Ito1, Hiroshi Kawamoto1, Satoshi Ozaki1, Hisashi Ohta1
1Tsukuba Res.Inst., Banyu Pharmaceut.Co., Ltd., 2Dept.Mol.& Syst.Pharmacol., Grad.Sch.Pharmaceut.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 256-256, 2009.

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P3O-A4-7 Neuroprotective effect of retinoid receptor agonist Am80 on dopaminergic neurodegeneration in vivo

Sachiko Takemori, Shigeru Kimura, Akinori Hisatsune, Yoishiro Isohama, Hiroshi Katsuki
Dept.Chemico-Pharmacol.Sci., Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 257-257, 2009.

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P3O-A4-8 Change in feeding behavior by knockdown of NPY Y1 receptor in mouse paraventricular nucleus-by in situ hybridization and immunohistochemistry

Tomohiro Shiiya, Shin-ichi Murase, Hiroshi Higuchi
Div.Pharmacol., Mol.Cell.Med., Niigata
Journal of Pharmacological Sciences 109 (suppl.2) 257-257, 2009.

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P3O-A6-1 Study on medication for cerebral infarction of elderly inpatients compared with other inpatients

Tang Jing1, 2, Liu Xiao-Yan1, 3, Zhang Lan4, Wang YuQin1, Shi Lu-Wen2
1Depart.Pharmacy, Xuan-wu Hospital of Capital Medical University, 2Department of Pharmaceutical Administration and Clinical Pharmacy, School of Pharmaceutical Science, Peking University, 3Department of Pharmacy, Fengtai Hospital, 4Department of Pharmacology, Xuanwu Hospital of Capital Medical University;Education Ministry Key Laboratory for Neuro-degenerative Disease
Journal of Pharmacological Sciences 109 (suppl.2) 257-257, 2009.

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P3O-A6-2 Preparation and characterization of solid dispersions of Quercetin with PEG4000

Yang Xiao-Zhan, Li Xiao-Hui
Dept Pharm., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 257-257, 2009.

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P3O-A6-3 The Prevalence and etiologies of macroprolactinemia in the general population

Naoki Hattori, Kaori Kitagawa, Tomoyuki Nakamura
Dept.Pharmacol., Kansai Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 258-258, 2009.

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P3O-A6-4 Ephrin/Eph family genes in atherosclerosis-related adult human cells:potential targets to regulate monocyte/macrophage chemotaxis

Aiji Sakamoto1, Hatsue Ueda2, Yuka Sugamoto1, Yuka Tokunaga1, Tsuyoshi Yoshimuta1, Takeo Higashikata1, Hitoshi Ogino3, Masakazu Yamagishi4
1Div.Biotechnol, Natl.Cardiovasc.Ctr.Res.Inst., 2Div.Pathol, Natl.Cardiovasc.Ctr., 3Div, Cardiovasc Surg, Natl.Cardiovasc.Ctr., 4Div.Cardiol., Kanazawa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 258-258, 2009.

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P3O-A6-5 Relationship between warfarin dose and single nucleotide polymorphism(SNP)genotype results tested by a rapid SNP detection system named SMAP on VKORC1(G-1639A)and CYP2C9*3(A1075C)in Japanese patients

Minoru Watanabe1, Naoki Matsumoto1, Toshio Kumai1, Yasumasa Mitani2, Yoshihide Hayashizaki2, Shinichi Kobayashi1
1Dept.Pharmacol., St.Marianna Univ.Sch.Med., 2RIKEN, Yokohama Institute
Journal of Pharmacological Sciences 109 (suppl.2) 258-258, 2009.

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P3O-A6-6 Consideration of research on some basic problems of clinical pharmacology

Wei Wei
Anhui Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 258-258, 2009.

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P3O-A6-7 Determination of JBP485 by LC/MS/MS and its pharmacokinetics in rats

Liu Ke-Xin1, Cang Jian1, Wang Chang-Yuan1, Liu Qi1, Zhang Jian1, Taiichi Kaku2
1College of pharmacy, Dalian Medical University, 2Japan Bioproducts Industry Co, Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 259-259, 2009.

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P3N-A7-1 A new method for analyzing myosin light chain phosphorylation with a Phos-tagTM technology

Mayumi Hirano, Katsuya Hirano
Div.Mol.Cardiol., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 259-259, 2009.

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P3N-A7-2 SanhuangXiexinTang attenuates vascular contraction by decreasing phosphorylation of the myosin phosphatase target subunit

Jin Fanxue, Li Xiangwu
Department of Anatomy and Histology & Embryology, Yanbian University School of Basic Medical Sciences
Journal of Pharmacological Sciences 109 (suppl.2) 259-259, 2009.

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P3N-A7-3 Roles of reactive oxygen species(ROS)and Rho-kinase in the thrombin-induced and proteinase-activated receptor 1(PAR1)-mediated pulmonary artery vasoconstriction

Jun Maki, Mayumi Hirano, Katsuya Hirano
Div.Mol.Cardiol., Grad.Sch.Med.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 259-259, 2009.

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P3N-A7-4 Inhibitory effect of Ginsenoside Rg1 on vascular smooth muscle cell proliferation in balloon-rubbed rats

Gao Yang, Huang Xie-Nan
Dept.Pharmacology, the Key Lab of Basic Pharmacology of Guizhou, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 260-260, 2009.

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P3N-A7-5 Gender differences in the development of balloon injury-induced neointimal formation are abolished by the genetic endothelin ETB receptor deficiency

Kento Kitada1, Tatsuhiko Mori2, Nozomi Yui1, Mamoru Ohkita1, Yasuo Matsumura1
1Lab.Pathol.and Mol.Pharmacol., Osaka Univ.Pharmaceut.Sci., 2Dept.Med III., Osaka Med.Col
Journal of Pharmacological Sciences 109 (suppl.2) 260-260, 2009.

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P3N-A7-6 Angiopoietin-1 protects ischemic heart exacerbated by hyperglycemia via increase of angiogenesis

Tuo Qin-Hui1, Chen Jian-Xiong2, Liao Duan-Fang1
1Institute of Pharmacy and Pharamacology, School of Life Science and Technology, University of South China, 2Division of Neonatology, Vanderbilt University Medical Center
Journal of Pharmacological Sciences 109 (suppl.2) 260-260, 2009.

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P3N-A7-7 Distribution and characterization of perivascular nerves in rat mesenteric arteries

Ayako Yokomizo1, Hidetoshi Fujiwara1, Mitsuhiro Goda1, Narumi Hobara2, Hiromu Kawasaki1
1Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ., 2Dept.life Sci., Okayama Univ.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 260-260, 2009.

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P3N-A7-8 Vascular responses to periarterial nerve stimulation(PNS)in mouse mesenteric vascular beds

Hiroki Fujiwara1, Yoshihiro Wake1, Fusako Takayama1, Yoshihisa Kitamura2, Hiromu Kawasaki1
1Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmc.Sci., Okayama Univ., 2Dept.Pharmc.Care Hlth.Sci., Grad.Sch.Med.Den.Pharmc.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 261-261, 2009.

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P3N-A8-1 Study on cardioprotection of ramipril against ischemia-reperfusion injury in diabetic rats

Wu Yan-Na, Zhang Zhe, Chen Yan, Jiao Jian-Jie, Kang Yi, Gao Wei-Zhen, Lou Jian-Shi, Liu Yan-Xia
Dept.of Pharmacology, Tianjin Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 261-261, 2009.

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P3N-A8-2 The effect of lysophosphatidic acid on myocardial ischemia-reperfusion injury

Shinichiro Kaji1, Hazuki Takenaga1, Naoshi Yamazaki1, Akira Tokumura2, Yoshiharu Takiguchi1
1Dept.Clin.Pharmacol., Inst.Health Biosci., Tokushima Univ.Grad.Sch., 2Dept.Health Che., Inst.Health Biosci., Tokushima Univ.Grad.Sch
Journal of Pharmacological Sciences 109 (suppl.2) 261-261, 2009.

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P3N-A8-3 Involvement of the sarcoplasmic reticulum in the automaticity of guinea-pig pulmonary vein myocardia

Yayoi Tsuneoka, Takahiko Sugimoto, Kiyoshi Takeda, Iyuki Namekata, Akira Takahara, Hikaru Tanaka
Dept.Pharmacol., Toho Univ.Fclt.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 261-261, 2009.

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P3N-A8-4 Effects of chronic administration of β-adrenoceptor antagonists on plasma membrane β-adrenoceptors of rat heart

Takahiro Horinouchi1, 2, 3, Shigeru Morishima1, Takashi Tanaka1, Fumiko Suzuki1, Yoshio Tanaka2, Katsuo Koike2, Soichi Miwa3, Ikunobu Muramatsu1
1Div.Pharmacol., Dept.Biochem.Bioinform.Sci., Fukui Univ.Sch.Med., 2Dept.Chem.Pharmacol., Toho Univ.Sch.Pharmaceut.Sci., 3Dept.Cell.Pharmacol., Hokkaido Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 262-262, 2009.

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P3N-A8-5 Cardioprotective effects of angiotensin converting enzyme(ACE)inhibitor through ACE signaling.

Yoshimi Aizaki1, Ayumu Yoshikawa1, Shinichiro Iida2, Makoto Katoh3, Xiao Sun1, Kei Maruyama1, Toshihiro Muramatsu2, Makoto Matsumura2, Shigeyuki Nishimura2, Takaaki Senbonmatsu1
1Dept.Pharmacol., Saitama Univ.Sch.Med., 2Saitama Univ.Sch.Med, 3Mitsubishi-tanabe CO
Journal of Pharmacological Sciences 109 (suppl.2) 262-262, 2009.

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P3N-A8-6 Study of the ameliorating effect of drugs on cardiac fanctions in myocardial infarction model animal

Yuuji Murata, Ryoji Mizumachi, Takahiro Matsumoto, Shinichi Ozato, Hiroshi Atai, Katsuhide Nishi
Mitsubishi Chemical Safety Institute Ltd.Kumamoto
Journal of Pharmacological Sciences 109 (suppl.2) 262-262, 2009.

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P3N-A8-7 Effects of angiotensin II receptor blocker in hamsters with dilated cardiomyopathy

Yoshizo Fukuda, Takumi Isomura, Tomoko Nagao, Miki Shirahata, Hironobu Ikeda, Shigenori Furukawa
NISSEI BILLS Co., Ltd., Shiga Laboratory
Journal of Pharmacological Sciences 109 (suppl.2) 262-262, 2009.

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P3N-A8-8 Protective effect of geranylgeranylacetone in desmin-related cardiomyopathy

Atsushi Sanbe1, Takuya Daicho2, Reiko Mizutani1, Noriko Miyauchi1, Junji Yamauchi1, Kouichi Tanonaka2, Akito Tanoue1
1Dept.Pharmacol., NRICHD, 2Dept.Pharmacol.Tokyo Univ.of Pharm.Life Sci
Journal of Pharmacological Sciences 109 (suppl.2) 263-263, 2009.

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P3N-A9-1 ERK5 mediates neurite outgrowth and tyrosine hydroxylase expression in PC12 cells

Arata Yamauchi1, Yutaro Obara1, 2, Shin Takehara1, Philip Stork2, Norimichi Nakahata1
1Dept.Cell.Signal., Grad.Sch.Pharmaceut.Sci., Tohoku Univ., 2Vollum Institute, OHSU
Journal of Pharmacological Sciences 109 (suppl.2) 263-263, 2009.

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P3N-A9-2 Dysfunction of neurotransmitter modulation system on adrenergic nerves of caudal artery in type 2 diabetic Goto-Kakizaki rats

Reiko Ishii-Nozawa1, Mitsuo Mita2, Masaru Shoji2, Koichi Takeuchi1
1Dept.Clin.Pharmacol., Meiji Pharmaceut.Univ., 2Dept.Pharmacodyn., Meiji Pharmaceut.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 263-263, 2009.

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P3N-A9-3 Effect of intrarenal stimulation by increasing of ureteral pressure on cardiovascular hemodynamics in rat treated with high salt

Yoshihide Fujisawa1, Yukiko Nagai1, Daisuke Nakano2, Shoji Kimura2, Hirofumi Hitomi2, Akira Nishiyama2
1Life Sci.Res.Center, Kagawa Univ., 2Dept.Pharmacol., Kagawa Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 263-263, 2009.

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P3N-A9-4 Effects of citrus flavonoids on catecholamine secretion in cultured bovine adrenal medullary cells

Ruka Sakamaki1, Yumiko Toyohira2, Susumu Ueno2, Masato Tsutsui2, Kouichi Nakata2, Kenji Toyama1, Nobuyuki Yanagihara2
1Dept.Nutr.Sci., Univ.SJG., 2Dept.Phamacol., Univ.Occup & Environ.Health, Japan Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 264-264, 2009.

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P3N-A9-5 Effects of physiological regulation through dopaminergic receptors in bovine adrenal chromaffin cells

Waki Tamura1, Mitsunori Hayashi2, Nobuyuki Sasakawa2, Konosuke Kumakura2
1Lab.Neurochem.and Neuropharmacol., Life Sci.Inst., Sopahia Univ., 2Dept.of Information & Communication Sci., Faculty of Sci.& Technolo.Sophia Univ
Journal of Pharmacological Sciences 109 (suppl.2) 264-264, 2009.

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P3N-A9-6 Geranylgeranylpyrophos phate is an essential isoprenoid for catecholamine secretion from adrenal chromaffin cells

Eiichi Tachikawa1, Maki Saito1, Yoshiyuki Tanabe1, Koichi Nakayama1, Yukiko Kondo2, Kenzo Mizuma2, Yasuyuki Irie2, Eiichi Taira2, Kenzo Kudo3, Hideharu Taira4
1Dept.Mol.Cellu.Pharmacol., Pharm.Sch., Iwate Med.Univ., 2Dep.Pharmacol., Sch.Med., Iwate Med.Univ., 3Dept.Pharm., Iwate Med.Univ.Hospital, 4Facul.Agri., Iwate Univ
Journal of Pharmacological Sciences 109 (suppl.2) 264-264, 2009.

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P3N-A9-7 Effects of nobiletin, a polymethoxy flavone, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells

Han Zhang1, 2, 3, Yumiko Toyohira1, Yuko Shinohara1, Susumu Ueno1, Masato Tsutsui1, Tohru Yamakuni2, Kojiro Takahashi3, Nobuyuki Yanagihara1
1Dept.Pharmacol., UOEH, Univ.Sch.Med., 2Grad.Sch.Pharmaceu.Sci.Tohuku Univ, 2Dept.Hos Pharmacy., UOEH, Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 264-264, 2009.

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P3N-A9-8 Involvement of α1A-adrenergic receptor in the methamphetamine-induced ejaculation, piloerection and eyelid retraction in rats

Kazue Kikuchi-utsumi1, Mami Ishizaka1, Nobuko Matsumura1, Hiroki Kumagai2, Ryoji Hayashi2, Toshio Nakaki1
1Dept.Pharmacol., Teikyo Univ.Sch.Med., 2Toray Ind., Inc., Pharmaceutical Res.Lab
Journal of Pharmacological Sciences 109 (suppl.2) 265-265, 2009.

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P3N-A10-1 An involvement of Activator of G-protein Signaling 8(AGS8)in hypoxia-induced apoptosis of cardiomyocytes

Motohiko Sato1, Takashi Honda1, Qibin Jiao1, Reiko Kurotani1, Eiji Toyota2, Stephen M.Lanier3, Yoshihiro Ishikawa1
1Cardiovascular Research Institute, Yokohama City University, 2Department of Cardiology, Kyokuto Hospital, 3Pharmacology, Medical University of South Carolina
Journal of Pharmacological Sciences 109 (suppl.2) 265-265, 2009.

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P3N-A10-2 Involvement of STIM1 in PAR1-mediated Ca2+ influx and NO production in vascular endothelial cells

Katsuya Hirano, Akiko Hanada, Mayumi Hirano
Div.Mol.Cardiol., Grad.Sch.Med.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 265-265, 2009.

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P3N-A10-3 Mechanisms of 5-hydroxytryptamine-induced cycolooxygenase-2 expression in rat vascular smooth muscle cells

Takuji Machida, Akina Onoguchi, Kenji Iizuka, Masahiko Hirafuji
Dept.Pharmacol., Facul.Pharm.Sci., Health Sci.Univ.of Hokkaido
Journal of Pharmacological Sciences 109 (suppl.2) 265-265, 2009.

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P3M-A10-4 Elevation of intracellular calcium in response to vasopressin and bradykinin in primary cultured rat isolated renal connecting tubule segments

Yuji Kamata1, 2, Tomoe Fujita2, Shuichi Yasuda3, Yoshikuni Fujita1, Masataka Majima2
1Dept.Endocrinol., Kitasato Univ.Sch.Med., 2Dept.Pharmacol., Kitasato Univ.Sch.Med., 3Center Genetic Biological., Kitasato Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 266-266, 2009.

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P3M-A10-5 The orphan GPCR GPR87 and P2Y10 receptors act as a novel lysophospholipid receptor

Kenichi Tabata, Masanori Murakami, Masatoshi Inden, Norihisa Fujita
Graduate School of Science and Engineering, Ritsumeikan Univ
Journal of Pharmacological Sciences 109 (suppl.2) 266-266, 2009.

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P3M-A10-6 Histamine H3 receptor expression is regulated by a newly-identified protein interacting with the receptor

Shiori Takayanagi1, 2, Kazuki Kinoshita1, 3, Takeya Sato1, Kay Maeda1, Mitsuya Haraguchi4, Kazuhiko Yanai2, Kohji Fukunaga3, 5, Teruyuki Yanagisawa1, 5, Jun Sukegawa1
1Dept.Mol.Pharmacol., Tohoku Univ.Grad.Sch.Med., 2Dept.Pharmacol., Tohoku Univ.Grad.Sch.Med., 3Dept.Pharmacol., Grad.Sch.Pharmaceut.Sci., Tohoku Univ., 4Mitsubishi Tanabe Pharma Corp., 5Tohoku Univ.21st Century COE Program"CRESCENDO"
Journal of Pharmacological Sciences 109 (suppl.2) 266-266, 2009.

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P3M-A10-7 Theaflavin protectects diabetic nephropathy through inhibiting glycogen synthase kinase-3beta

Li Cairong1, Cai Fei1, Chen Huanhuan2, Zhao Xinyuan1, Li Juan1
1Medical College, Xianning University, 2The people hospital of Jingzhou
Journal of Pharmacological Sciences 109 (suppl.2) 266-266, 2009.

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P3M-A11-1 Bone marrow-derived EP3-expressing stromal cells enhanced tumor-associated angiogenesis and tumor growth with increased recruitment of VEGFR-1/VEGFR-2 positive cells

Yasufumi Ogawa1, 2, Atsuhiko Oikawa1, Tatsunori Suzuki1, Kanako Hosono1, Hideki Amano1, Masahiko Watanabe2, Syuh Narumiya3, Masataka Majima1
1Dept.Pharmacol, Kitasato Univ.Sen.Med., 2Dept.Surge, Kitasato Univ.Sch.Med., 3Dept.Pharmacol, Kyouto Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 267-267, 2009.

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P3M-A11-2 Preliminary biological evaluation of chrysin derivatives as potential anticancer drugs

Zhenga Xing1, Zhaoa Fei Fei1, Yaoa Xu1, Tong Zhengb Zi2, Mei Liua Yun1, Fang Liaoa Duan1
1Institute of Pharmacy & Pharmacology, University of South China, 2Chuanshan College, University of South China
Journal of Pharmacological Sciences 109 (suppl.2) 267-267, 2009.

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P3M-A11-3 Differentiation-inducing factor-1 inhibits angiogenesis in vitro and in vivo

Tatsuya Yoshihara1, 2, Fumi Takahashi1, Toshiyuki Sasaguri1
1Dept.Clin.Pharmacol., Fac.Med.Sci., Kyushu Univ., 2Dept.Anesth.Crit.Care.Med., Fac.Med.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 267-267, 2009.

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P3M-A11-4 Mcl-1 as a target for the therapy of squamous cell carcinoma

Masahide Nagata1, 2, Koichiro Wada1, Morio Kusayama1, 2, Seiji Iida2, Masaya Okura2, Mikihiko Kogo2, Yoshinori Kamisaki1
1Dept.Pharmacol., Grand.sch.Dent., Osaka Univ., 21st Dept.Oral and Maxillofacial Surg., Grand.Sch.Dent., Osaka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 267-267, 2009.

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P3M-A11-5 Correlation analysis of BRCA1 and related genes expression and pathological parameters in sporadic breast carcinoma

Ren Jie, Wei Minjie, Zhao Lin, Wang Lin, Ma Wenfeng, Sun Mingli
Dept.of Pharmacol., Pharmaceutical College of China Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 268-268, 2009.

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P3M-A11-6 The hypermethylation of BRCA1 promoter related to sporadic breast carcinomas genesis in Chinese women

Wei Minjie, Ren Jie
Dept.of Pharmacol., Pharmaceutical College of China Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 268-268, 2009.

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P3M-A11-7 Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells

Fumi Takahashi, Tatsuya Yoshihara, Kentaro Jingushi, Toshiyuki Sasaguri
Dept.Clinical Pharmacol., Fac.Med.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 268-268, 2009.

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P3M-A11-8 Roles of AT2 receptor signaling in ascites accumulation and intraperitoneal bleeding in a mouse peritoneal carcinomatosis model

Kento Nakatani, Tatsunori Suzuki, Kanako Hosono, Masataka Majima
Dept.Pharmacol., Kitasato Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 268-268, 2009.

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P3M-A12-1 The effect of external anti-inflammatory drugs on adjuvant-induced arthritis and inflammatory markers

Takashi Miyata, Katsunori Morishita, Nobuhiro Goi, Megumi Yokota, Takayuki Ishii
Mikasa seiyaku Co., Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 269-269, 2009.

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P3M-A12-2 Sustained expression of cyclooxygenase-2 by bradykinin and interleukin-1β in primary cultured rat dorsal root ganglion cells

Atsuko Inoue, Kaori Ishii, Megumi Tanaka, Norimitsu Morioka, Yoshihiro Nakata
Dept.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 269-269, 2009.

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P3M-A12-3 Study of Asparagus officinalis polysaccharide on the function of erythrocyte in S180 mice on immunological reaction of lymphocytes

Yu Liu, Yu-bin Ji, Chen-feng Ji, Yong-cui Min
Postdoctoral Research Station, Life Sciences and Environmental Sciences Research Center, Harbin University of Commerce
Journal of Pharmacological Sciences 109 (suppl.2) 269-269, 2009.

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P3M-A12-4 Dregea volubilis ameliorates concanavalin A-induced liver injury by facilitating apoptosis of activated T cells

Yan Shen, Fang Gong Yuan, Qiang Xu
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University
Journal of Pharmacological Sciences 109 (suppl.2) 269-269, 2009.

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P3M-A12-5 Immunosuppressive effect of Cordyceps sinensis:inducing the phenotypic and functional immaturities of human derived dendritic cells

Jing Tang, Gaolin Liu
Affiliated First People's Hospital of Shanghai Jiaotong University
Journal of Pharmacological Sciences 109 (suppl.2) 270-270, 2009.

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P3M-A12-6 Importance of the pharmaco-dynamics of monoclonal antibodies for human use during risk evaluation in the review process

Tamiko Suzuki-Nishimura
Pharmacy School, Shujitsu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 270-270, 2009.

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P3M-A12-7 Effect of Asparagus polysaccharide on the number and activity of erythrocyte complement receptor 1(CD35)of S180 mice

Dong Fang1, Ji Yu-bin, Ji Chen-feng, Min Yong-cui
1Center of Research on Life Sciences and Environmental Sciences, Harbin University of Commerce, 2Engineering Research Center of Natural Anticancer Drugs, Ministry of Education
Journal of Pharmacological Sciences 109 (suppl.2) 270-270, 2009.

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P3O-P1-1 Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice

Naoko Ishikawa, Tsuyoshi Nishioku, Shinya Dohgu, Fuyuko Takata, Kota Kodama, Hideki Shuto, Atsushi Yamauchi, Yasufumi Kataoka
Dept.Pharm.Care Health Sci., Fac.Pharm.Sci., Fukuoka Univ
Journal of Pharmacological Sciences 109 (suppl.2) 270-270, 2009.

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P3O-P1-2 A high-sodium diet in streptozotocin(STZ)-induced diabetic rats impairs baroreceptor reflex;aldosterone sensitive neurons in the nucleus tractus solitarius(NTS)

Tomoharu Masuda1, Yusuke Nakamura1, Masayuki Miyakawa1, Yasutoshi Hirabara1, 2, Kenji Honda1, Ryo Saito1, Kazuhiko Arimori2, Hiroyuki Nakagawa3, Hirotaka Sakamoto4, Mitsuhiro Kawata4, Yukio Takano1
1Dept.Physiol.and Pharmacol.Sci, Fac.Pharmaceutical Sci., Fukuoka Univ., 2Dept.Pharm., Fac.Med., Univ.of Miyazaki Hosp., 3Div.Biol., Fac.Sci., Fukuoka Univ., 4Dept.Anat.and Neurobiology, Kyoto Prefectural Univ.of Med
Journal of Pharmacological Sciences 109 (suppl.2) 271-271, 2009.

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P3O-P1-Disruption of BBB in rat MCAO and a protective effect of anti-HMGB1 antibody

Keyue Liu1, 2, 3, Jiyong Zhang1, Hideo Takahashi1, Yakuko Tomono2, Hidenori Wake1, Aiji Otsuka1, Shuji Mori3, Masahiro Nishibori1
1Dept.Pharmacol., Okayama Univ.Sch.Med, 2Shigei Med.Institute, 3Shujitsu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 271-271, 2009.

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P3O-P1-4 Effect of an artificial oxygen carrier on emotional dysfunction in rats after cerebral ischemia

Naobumi Hamadate1, Taku Yamaguchi1, Hiroko Togashi2, Jin Kakehata1, Takeshi Izumi1, Takayuki Yoshida1, Mitsuhiro Yoshioka1
1Dept.Neuropharmacol., Hokkaido Univ.Grad.Sch.Med., 2Dept.Pharmacol., Fac.Pharm.Sch., Hlth.Sci.Univ.Hokkaido
Journal of Pharmacological Sciences 109 (suppl.2) 271-271, 2009.

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P3O-P1-Combination of CP and D2 dopaminergic receptor antagonist potently improves voiding dysfunction associated with CI in rats

Daisuke Kadohisa, Gen Yamamoto, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept.Environ.Mol.Health Sci., Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 271-271, 2009.

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P3O-P1-6 Resveratrol reduces the expression of VCAM-1 and ICAM-1 after spinal cord injury in rats

Yang Yingbao1, Luo Jinghui2
1Department of Pharmacology, School of Pharmaceutical Sciences, 2Department of Pharmacy, Nanfan Hospital, Southern Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 272-272, 2009.

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P3O-P1-7 Altered expression of angiotensin II type 1 receptor in the brain after long-term administration of antihypertensive drugs in stroke-prone spontaneously hypertensive rat

Yayoi Nishida1, Yasuo Takahashi1, Megumi Kobayashi2, Satoshi Asai1
1Div.Genomic.Epidem.Clin.Trials, Nihon Univ.Sch.Med., 2Dept.Pharmacol., Nihon Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 272-272, 2009.

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P3O-P1-8 The role of carnosine in CNS

Fan Yan-Ying, Zhang Jian-Xiang, He Ping, Chen Zhong
Dept.Pharmacol., Sch.of Med., Zhejiang Univ
Journal of Pharmacological Sciences 109 (suppl.2) 272-272, 2009.

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P3O-P2-1 Histone deacetylase inhibitors enhance serotonin-stimulated BDNF gene expression in C6 glioma cells through their differentiation mediated by 5α-reduced neurosteroids

Kyoji Morita1, Song Her2
1Lab.Neuropharmacol., Dept.Nursing, Shikoku Univ.Sch.Health Sci., 2Div.Bio-Imaging, Chuncheon Ctr., Korea Basic Sci.Instit
Journal of Pharmacological Sciences 109 (suppl.2) 272-272, 2009.

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P3O-P2-2 Acute mirtazapine treatment enhances hippocampal cell proliferation in adult rats via 5-HT1A receptor activation

Koichi Kitamura, Nobukazu Kakui, Nobuyuki Yamashita, Taiichiro Imanishi
Pharmaceutical Research Center, Meiji Seika Kaihsa, Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 273-273, 2009.

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P3O-P2-3 AVP4-9, a vasopressin metabolite, promotes axonal growth in rat cultured hippocampal neurons

Yasuhisa Nakayama, Tomoyuki Nakamura
Dept.Pharmacol., Kansai Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 273-273, 2009.

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P3O-P2-4 About low molecular beta-amyloid derivatives

Taizo Hayano1, Shiroh Kishioka2, Hiroyuki Yamamoto2
1Div.Psychiat.Wakaura.Hosp., 2Dept.Pharmacol.School.Med.Wakayama
Journal of Pharmacological Sciences 109 (suppl.2) 273-273, 2009.

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P3O-P2-5 α-synuclein overexpression in PC12 impairs dopamine release by upregulating exocytosis-related proteins

Zhang Wei, Yuan Yu-He, Chen Nai-Hong
Dept.Pharmacol., Inst.Materia Medica, CAMS & PUMC
Journal of Pharmacological Sciences 109 (suppl.2) 273-273, 2009.

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P3O-P2-6 Effect of adenosine on leptin-induced STAT3 activation

Chie Terauchi, Toru Hosoi, Hisashi Kodama, Noritaka Sugiyama, Koichiro Ozawa
Dept.Pharmacotherapy., Grad.Sch.Biomed.Sci.Hiroshima Univ
Journal of Pharmacological Sciences 109 (suppl.2) 274-274, 2009.

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P3O-P2-7 Specific detection of oxidized ER enzyme linked to onset of neurodegenerative disorders

Mariko Asada, Masabumi Mimami, Takashi Uehara
Dept.Pharmacol.Grad.Sch.Pharmaceu.Sci.Hokkaido Univ
Journal of Pharmacological Sciences 109 (suppl.2) 274-274, 2009.

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P3O-P2-8 The neuroprotective effects of PARK7(DJ-1)against oxidative stress-induced neuronal cell death

Atsuko Yamamoto1, Yoshihisa Kitamura1, Daijiro Yanagisawa1, Kazuyuki Takata1, Takashi Taniguchi1, Takahiro Taira2, Hiroyoshi Ariga3
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2Dept.Mol.Cell Biol., Interdiscip Grad.Sch.Med.Eng., Yamanashi Univ., 3Dept.Mol.Biol., Grad.Sch.Parm.Sci., Hokkaido Univ
Journal of Pharmacological Sciences 109 (suppl.2) 274-274, 2009.

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P3O-P3-1 Possible involvement of endogenous nitric oxide-induced S-nitrosylation of cyclooxygenase in centrally administered bombesin-induced activation of central adrenomedullary outflow in rats

Lianyi Lu, Takahiro Shimizu, Kumiko Nakamura, Kunihiko Yokotani
Dept.of Pharmacol., Sch.of Medicine, Kochi Univ
Journal of Pharmacological Sciences 109 (suppl.2) 274-274, 2009.

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P3O-P3-2 Translocation of nNOS to the plasma membrane by ATP is mediated by P2X and P2Y receptors

Takayuki Ohnishi1, 2, Shinji Matsumura2, Emiko Okuda-Ashitaka2, Hiroshi Higuchi1, Seiji Ito2
1Div.Pharmacol., Mol.Cell.Med., Niigata Univ., Grad.Sch.Med.Den.Sci., 2Dept.Med.Chem., Kansai Medical Univ
Journal of Pharmacological Sciences 109 (suppl.2) 275-275, 2009.

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P3O-P3-3 RACK1 is involved in morphine reward in mice

Wan Lihong1, 2, Liu Yanyou1, Wang Yuhui1, Wang Zhengrong1
1Key Laboratory of Chronobiology, Ministry of Health(Sichuan University), Sichuan University, 2Department of pharmacology, Sichuan University
Journal of Pharmacological Sciences 109 (suppl.2) 275-275, 2009.

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P3O-P3-4 Rac1 inhibition negatively regulates the transcriptional activity of the amyloid precursor protein gene

Pilin Wang, Tetsuhiro Niidome, Takeshi Kihara, Hachiro Sugimoto
Dept.Neurosci.Drug Discov., Grad.Sch.Pharmaceu.Sci., Kyoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 275-275, 2009.

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P3O-P3-5 Changes in central adenosine A1 receptor during hibernation period in Syrian hamsters

Yutaka Tamura1, Mayuko Monden1, Tomoko Saitoh1, Hirohito Shiomi1, 2
1Fac.Pharmacy & Pharmaceutical Sic., Fukuyama Univ., 2Research Center for Green Science, Fukuyama Univ
Journal of Pharmacological Sciences 109 (suppl.2) 275-275, 2009.

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P3O-P3-6 Effects of endothelin-1 on the expression of tight junction proteins in brain microvessel endothelial cells

Kazuhiro Tanaka, Yutaka Koyama
Lab.Pharmacology, Faculty of Pharmacy, Osaka Ohtani Univ
Journal of Pharmacological Sciences 109 (suppl.2) 276-276, 2009.

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P3O-P3-7 Functional differences of serotonin 2C receptor(5-HT2CR)isoforms produced from edited mRNA:elucidation in Xenopus oocytes

Pham.T.N.Hang, Michihisa Tohda, Naofumi Kobayashi, Kinzo Matsumoto
Div.of Medicinal Pharmacology, Res.Inst.of Natl.Med., Univ.of Toyama
Journal of Pharmacological Sciences 109 (suppl.2) 276-276, 2009.

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P3O-P3-8 Cloperastine increases dopamine level in the nucleus accumbens of rats

Masako Inoue, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept.Environ.Mol.Health Sci., Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 109 (suppl.2) 276-276, 2009.

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P3O-P4-1 Role of GPR30 in proliferation of C6 glioma cells

Yasunari Kanda, Ken Nakazawa
Div.Pharmacol., Natl.Inst.Hlth Sci
Journal of Pharmacological Sciences 109 (suppl.2) 276-276, 2009.

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P3O-P4-2 Regulation by p38 MAPK on hydrogen peroxide-induced thymidine incorporation in cultured astrocytes

Koh-ichi Tanaka1, 2, Tomoaki Sato2, Takashige Nishikawa2, Junichi Kitanaka3, Nobue Kitanaka3, Motohiko Takemura3, Nobuyoshi Nishiyama1
1Div.Pharmacol., Dept.Pharm., Sch.Pharm., Hyogo Univ.Health Sci., 2Dept.Applied Pharmacol., Kagoshima Univ.Grad.Sch.Med.& Dent.Sci., 3Dept.Pharmacol., Hyogo Col.Med
Journal of Pharmacological Sciences 109 (suppl.2) 277-277, 2009.

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P3O-P4-3 Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes

Kazunori Kanemaru1, Jun Kubota1, Yohei Okubo1, Kenzo Hirose2, 3, Masamitsu Iino1
1Dept.Pharmacol., Sch.Med., Univ.Tokyo., 2Dept.Cell Physiol., Sch.Med., Nagoya Univ., 3Dept.Neurobiol., Sch.Med., Univ.Tokyo
Journal of Pharmacological Sciences 109 (suppl.2) 277-277, 2009.

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P3O-P4-4 Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells

Toshiaki Ishii, Tomoka Uto, Kaori Mori, Ryu Fujikawa
Dept.Basic Vet.Med., Obihiro Univ.Agri.and Vet.Med
Journal of Pharmacological Sciences 109 (suppl.2) 277-277, 2009.

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P3O-P4-5 Effects of L-theanine on dopaminergic neuronal cells

Megumi Someya1, Mika Takeshima1, Maiko Murata1, Ikuko Miyazaki2, Masato Asanuma2, Taizo Kita1
1Lap.Pharmacol., Kyushu Nutrition Welfare Univ.Grad.Sch.Food and Nutrition., 2Dept.Brain Sci., Okayama Univ.Grad.Sch.Med., Dent.& Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 277-277, 2009.

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P3O-P4-6 Effects of docosahexaenoic acid on dopaminergic neuronal cells

Maiko Murata1, Mika Takeshima1, Megumi Someya1, Ikuko Miyazaki1, 2, Masato Asanuma2, Taizo Kita1
1Lab.Pharmacol., Kyushu Nutrition Welfare Univ.Grad.Sch.Food and Nutrition., 2Dept.Brain Sci., Okayama Univ.Grad.Sch.Med., Dent.Pharmac.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 278-278, 2009.

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P3O-P4-7 Micropharmacological application of micro-culture device for single cells on microfluidic system

Taku Watanabe1, 2, Youko Otubo1, 2, Takahiro Arakawa2, Shuichi Shoji1, 2, Yoshinori Yamaguchi1, Yoshikuni Edagawa1
1Inst Biomed Eng, ASMeW, Waseda Univ., 2Fac Sci Eng, Waseda Univ
Journal of Pharmacological Sciences 109 (suppl.2) 278-278, 2009.

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P3O-P4-8 Gs-linked receptor GPR3 regulates proliferation and differentiation of cerebellar granule neuron precursors

Shigeru Tanaka1, 2, Imran M.Shaikh2, E.Antonio Chiocca2, Yoshinaga Saeki2, Norio Sakai1
1Dept.Mol.and Pharmacol.Neurosci., Hiroshima Univ.Sch.Med., 2Dept.Neurol.Surg.The Ohio state Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 278-278, 2009.

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P3O-P5-1 Simultaneous determination of lamotrigine, phenobarbitone, carbamazepine and phenytoin in human brain tissue by high-performance liquid chromatography

Shen Jiang-Hua, Jiang De-Chun, Wang YuQin
Depart.Pharmacy, Xuan-wu Hospital of Capital Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 278-278, 2009.

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P3O-P5-2 Simultaneous and simple measurements of histamine and 1-methylhistamine by using HPLC-fluorometry

Toshie Izutsu, Eiko Sakurai, Ayako Oikawa, Naoko Takino, Kazuhiko Yanai
Dept.Pharmacol., Tohoku Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 279-279, 2009.

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P3O-P5-3 Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity

Yuri Kikkawa1, Naotaka Kimoto1, Saki Fukuoka2, Ikuko Miyazaki1, Masato Asanuma1
1Dept.of Brain Sci., Okayama Univ.Grad.Sch.of Med., Dent.and Pharmaceut.Sci., 2Dept.of Clinical Pharm., Okayama Univ.Grad.Sch.of Med., Dent.and Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 279-279, 2009.

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P3O-P5-4 Three distinct dopamine D1-like receptor signaling pathways

Mahomi Kuroiwa1, Helen S.Bateup2, Takahide Shuto1, Akinori Nishi1
1Dept.Pharmacol., Kurume Univ.Sch.Med., 2Lab.of Mol.and Cell.Neurosci.The Rockefeller Univ
Journal of Pharmacological Sciences 109 (suppl.2) 279-279, 2009.

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P3O-P5-5 Altered iron homeostasis caused by rotenone in dopaminergic SH-SY5Y cells

Karo Tanaka, Toshio Nakaki
Dept.Pharmacol., Teikyo Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 279-279, 2009.

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P3O-P5-6 Effects of melatonin on pethidine-induced physical dependence and its antioxidative action#

Li Shu-Hui1, 2, Li Xiao-Hui1
1Dept.Pharm, Third Mil. Med.Univ., 2Dept Clin Biochem., Third Mil.Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 280-280, 2009.

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P3O-P5-7 Distinct contributions of noradrenergic and serotonergic systems to the analgesic effects of milnacipran on thermal and mechanical hypersensitivity

Yu Kinoshita, Shohei Yamamoto, Mitsuo Tanabe, Hideki Ono
Lab.CNS Pharmacol., Grad.Sch.Pharm.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 109 (suppl.2) 280-280, 2009.

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P3O-P5-8 No involvement of descending noradrenergic or serotonergic neurons in the supraspinally mediated anti-allodynic effects of fluoxetine, a SSRI

Yu Kinoshita, Motoko Honda, Shohei Yamamoto, Mitsuo Tanabe, Hideki Ono
Lab.CNS Pharmacol., Grad.Sch.Pharm.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 109 (suppl.2) 280-280, 2009.

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P3O-P6-1 Application of a heat-and steam-generating sheet to bilateral eyes produces parasympathetic predominance and improves systemic hemodynamics

Yoshinao Nagashima1, Michihito Igaki1, Atsushi Suzuki1, Yukihiro Yada1, Shuuichi Tsuchiya1, Toshiyuki Suzuki1, Sachiko Oh-ishi2
1Tokyo Research Laboratories, Kao Corporation, 2Kitasato University
Journal of Pharmacological Sciences 109 (suppl.2) 280-280, 2009.

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P3O-P6-2 Serum vitamin K concentration and PT-INR with well controlled patients under warfarin therapy

Naoki Matsumoto1, Masahiro Yamauchi2, Kensuke Kawasaki2, Eiji Takahashi2, Miwa Tateshi2, Seishou Kou2, Ryoji Kishi3, Shonosuke Ryu3, Yukako Ishikawa3, Sachiko Takenoshita1, Yuko Takeba1, Yoshie Harimoto1, Minoru Watanabe1, Masami Tanaka1, Mikihito Hayashi1, Fumihiko Miyake3, Haruki Musha2, Shinichi Kobayashi1
1Depart.Phamacol., St.Marianna Univ.Sch.Med., 2Cardiol.St.Marianna Univ.Yokohama-shi-Seibu Hosp., 3Depart.Cardiol., St.Marianna Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 281-281, 2009.

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P3O-P6-3 Dosage regimen optimization of total panax notoginsenoside injection by the evaluation of population pharmacokinetic and pharmacodynamic in cerebral apoplexy patient

Xiao-Zhan Xiaoyu1, Wang Guangji2, Xiong Yuqing3, Sun Jianguo2, Hao Haiping2, Liu Gaolin1, Bei Yan2, Zheng Uanting2
1Department of Clinical Pharmacy, Affiliated First People Hospital of Shanghai Jiaotong University, 2Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Institute of Clinical Pharmacology, Medical College of Nanchang University, 3Institute of Clinical Pharmacology, Medical College of Nanchang University
Journal of Pharmacological Sciences 109 (suppl.2) 281-281, 2009.

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P3O-P6-4 Gender difference in histamine H1 receptors in the human brain:A human PET study

Motohisa Kato1, Manabu Tashiro2, Masahiko Yoshizawa3, Dongying Zhang1, Nobuyuki Okamura1, Shin Fukudo4, Kazuhiko Yanai1
1Dept.Pharmacol., Tohoku Univ.Grad.Sch.Med, 2Div.Nucl.Med., Cyclotron RI Center, Tohoku Univ., 3Dept.Psychosomat.Med., Tohoku Univ.Sch.Med., 4Dept.Behav.Med., Tohoku Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 281-281, 2009.

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P3O-P6-5 Conducting clinical trials in the PR of China

Wang Shaohua, Zhao Yan
Department of Pharmacy, Qingdao Municipal Hospital
Journal of Pharmacological Sciences 109 (suppl.2) 281-281, 2009.

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P3O-P6-6 A high cost medical insurance case discussion

Jia Dan, Chu Yan-Qi, Yan Su-Ying, Shen Qian, Zeng Yan, Li Tian-Qi, Qi Xiao-Lian, Wang Shu-Jie, Xu Yan-Xia, Wang YuQin
Dept.Pharmay, Xuanwu Hospital of Capital Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 282-282, 2009.

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P3N-P7-1 Effects of naftopidil on noradrenalin-induced vascular smooth muscle cell proliferation

Li Li-Sheng, Sun An-Sheng, Yu Li-Mei, Wu Qin, Hunag Xie-Nan
Dept.Pharmacology, the Key Lab of Basic Pharmacology of Guizhou, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 282-282, 2009.

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P3N-P7-2 Rutaecarpine inhibits proliferation in rat vascular smooth muscle cells

Sun An-Sheng1, 2, Li Yan-Ju1, Liu Jie2
1Department of Pharmacology, Zunyi Medical College, 2the Key Laboratory of Basic Pharmacoligy of Guizhou, Zunyi Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 282-282, 2009.

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P3N-P7-3 Inhibitory effect of panaxynol on the proliferation of rat aortic smooth muscle cell and its mechanisms

Jiang Liping1, 2, Lu Yang2, Chen Hongzhuan2
1Nanchang University School of Medicine, 2Shanghai Jiao Tong University School of Medicine
Journal of Pharmacological Sciences 109 (suppl.2) 282-282, 2009.

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P3N-P7-4 Role of NF-κB and Akt/eNOS on vascular inflammation and stroke prevention in stroke-prone hypertensive rats(SHRSP)

Atsuko Niwa, Masaki Tabuchi, Kana Ooshima, Hiroshi Sakaue, Hideaki Higashino
Dept.Pharmacol., Kinki Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 283-283, 2009.

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P3N-P7-5 Mechanism of enhanced vascular superoxide production and effect of chronic administration of pravastatin in a type 2 diabetes rat model

Chigusa Kikuchi1, 2, Junko Kajikuri2, Takeo Itoh2, Chie Shin1, Kazunori Kimura1
1Educ.Res.Ctr.Clin.Pharm.Nagoya City Univ.Grad.Sch.Pharmaceut.Sci., 2Dept.Pharmacol.Nagoya City Univ.Grad.Sch.Med.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 283-283, 2009.

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P3N-P7-6 Impairment of store-operated Ca2+ entry in caudal arterial smooth muscle of type 2 diabetic Goto-Kakizaki rat

Kazushi Itoh, Mitsuo Mita, Masaru Shoji
Dept.Pharmacodyn., Meiji Pharmaceutical Univ
Journal of Pharmacological Sciences 109 (suppl.2) 283-283, 2009.

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P3N-P7-7 NADPH oxidase contributes to anti-hypertensive effects of statin in murine animal models

Wenhao Cui, Kuniharu Matsuno, Chihiro Yabe
Dept.Pharmacol., Kyoto Pref.Univ.Med
Journal of Pharmacological Sciences 109 (suppl.2) 283-283, 2009.

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P3N-P7-8 Development of atherosclerosis, and pro-and anti-atherosclerotic markers in KHC rabbits

Kazuyoshi Kunishiro, Tomohiro Miike, Mamoru Kanda, Satoko Yougai, Hiroaki Shirahase
Research Laboratories, Kyoto Pharmaceutical Industries, Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 284-284, 2009.

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P3N-P8-1 Targeting at SUR2B/Kir6.1 subtype of ATP-sensitive potassium channel opener natakalim improves pressure overload-induced heart failure

Tang Yuan1, 2, Long Chaoliang2, Wang Hai2
1Institute of Materia Medica, College of Pharmacy, Third Military Medical University, 2Department of Cardiovascular Pharmacology, Beijing Institute of Pharmacology and Toxicology
Journal of Pharmacological Sciences 109 (suppl.2) 284-284, 2009.

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P3N-P8-2 Remodeling of Ca2+ channels in rat right atrium with monocrotaline-induced pulmonary hypertension

Takashi Koyama1, Hiroyuki Watanabe1, Takayoshi Ohba2, Manabu Murakami2, Kyoichi Ono2, Hiroshi Ito1
1Dept.Cardiol., Akita Univ.Sch.Med., 2Dept.Physiol., Akita Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 284-284, 2009.

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P3N-P8-3 Terfenadine delayed cardiac repolarization, but its active metabolite, fexofenadine, did not affect it assessed in the halothane anesthetized dogs

Kentaro Ando1, Hiyoyuki Harada2, Hiroyoshi Miyamaoto2, Naoki Inamura2, Yuji Nakamura3, Atsushi Sugiyama3
1Vet.Med.Science, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 2Mitsubishi Tanaba Pharma Co.Toxicology Laboratory, 3Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
Journal of Pharmacological Sciences 109 (suppl.2) 284-284, 2009.

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P3N-P8-4 Electropharmacological effects of pentamidine isetionate, an antiprotozoal agent, assessed in the halothane-anesthetized canine model

Hirofumi Yokoyama1, 2, Yuji Nakamura1, Hiroshi Iwasaki1, Yukitoshi Nagayama1, 3, Kiyotaka Hoshiai1, 3, Yoshitaka Mitsumori1, Atsushi Sugiyama1, 3
1Dept.Pharmacol., Univ.of Yamanashi, 2Nippon Kayaku Co., Ltd.Pharmaceutical Research Lab., 3YRCCP
Journal of Pharmacological Sciences 109 (suppl.2) 285-285, 2009.

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P3N-P8-5 Utility of a new MAP recording system for guinea pigs:analysis of effects of antitussive drug clobutinol on the ventricular repolarization phase in vivo

Akira Takahara, Mariko Nakamura, Akiko Sendo, Iyuki Namekata, Hikaru Tanaka
Dept.Pharmacol., Toho Univ.Fclt.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 285-285, 2009.

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P3N-P8-6 Comparison of the effects of bepridil on the action potentials between the pulmonary vein myocardium and the left atrium in guinea pigs

Kiyoshi Takeda, Takahiko Sugimoto, Iyuki Namekata, Akira Takahara, Hikaru Tanaka
Dept.Pharmacol., Toho Univ.Fclt.Pharmaceut.Sci
Journal of Pharmacological Sciences 109 (suppl.2) 285-285, 2009.

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P3N-P8-7 Effects of Zhigancao Decoction on arrhythmia with syndrome of deficiency of both Qi and blood in rats

Chen Lan-ying, Luo Xiong
The National Pharmaceutical Engineering Center(NPEC)for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine
Journal of Pharmacological Sciences 109 (suppl.2) 285-285, 2009.

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P3N-P8-8 Acute and subacute supraventricular arrhythmias induced by topical application of 5% glutaraldehyde on the sino-atrial region of the guinea-pig heart

Atsuko Katoh, Keiko Azuma, Hiroshi Atai, Katsuhide Nishi
Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 286-286, 2009.

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P3N-P9-1 Improving effects of scutellaria flavonoid, an extract from traditional Chinese medicine against cerebral ischemia injury in rats following middle cerebral artery occlusion

Shang Ya-Zhen
Hebei Province Key Labortory of Traditional Chinese Medicine Research and Development/Institute of Traditional Chinese Medicine, Chengde Medical College
Journal of Pharmacological Sciences 109 (suppl.2) 286-286, 2009.

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P3N-P9-2 The examination of usefulness of sleep apnea syndrome model rats

Takahiro Matsumoto, Ryoji Mizumachi, Yuji Murata, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Dept.Pharmacol., Mitsubishi Chemical Safety Institute Ltd
Journal of Pharmacological Sciences 109 (suppl.2) 286-286, 2009.

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P3N-P9-3 Cardiac diastolic dysfunction occurs in SHRSP.Z-Leprfa/IzmDmcr rats with metabolic syndrome

Yukari Tada, Satomi Kagota, Namie Nejime, Kazuki Nakamura, Masaru Kunitomo, Kazumasa Shinozuka
Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University
Journal of Pharmacological Sciences 109 (suppl.2) 286-286, 2009.

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P3N-P9-4 8-Methyltryptanthrin induces cardiac differentiation of P19CL6 embryonic carcinoma cells

Kazuhiko Seya1, Asako Yamaya1, 2, Sayuri Kamachi1, 3, Haruo Kitahara3, Jun Kawakami2, Ken Okumura4, Shigeru Motomura1, Ken-Ichi Furukawa1
1Dept.Pharmacol., Hirosaki Univ.Grad.Sch.Med., 2Course Mater.Sci.Tech., Hirosaki Univ.Grad.Sch.Sci.Tech., 3Fac.Edu., Hirosaki Univ., 4Dept.Cardiol., Hirosaki Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 287-287, 2009.

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P3N-P9-5 Characterization of cardiomyocytes newly generated ex vivo by culturing adult sinoatrial node cells

Shigeki Kiuchi1, Fuminori Otsuka2, Tae Shimoyama2, Rie Ito1, Shigeto Suzuki1, Takashi Uezono1, Junichi Kurihara1, Kageyoshi Ono1
1Dept.Pharmacol., Fac.Pharmaceut.Sci., Teikyo Univ., 2Dept.Mol.Environm.Hlth., Fac.Pharmaceut.Sci., Teikyo Univ
Journal of Pharmacological Sciences 109 (suppl.2) 287-287, 2009.

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P3N-P9-6 Breviscapine inhibited the expression of adhesion molecules in human umbilical endothelial cells

Jiangping Xu, Yufang Cheng, Qian Wang
Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 287-287, 2009.

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P3N-P9-7 Mechanism of endothelial ROS generation by oxidative stress

Masamichi Tajima, Hiroshi Sakagami
Div.Pharmacol., Dep.Diagnostic and Therapeutic Sciences, Meikai Univ.Sch.Dent
Journal of Pharmacological Sciences 109 (suppl.2) 287-287, 2009.

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P3N-P9-8 Elevation in rat skin temperature detected by thermography was induced by beraprost sodium, a prostacyclin derivative

Teruo Matsushita, Ryusuke Tanaka
Dept.Food Sci., Nat.Fish.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 288-288, 2009.

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P3M-P10-1 CREB binding sites in cellular model for morphine-dependency

Taka-aki Koshimizu1, Hiroyoshi Tsuchiya1, Hidetoshi Tsuda2, Akio Fujimura2
1Dev.Mol.Pharmacol., Dep.Pharmacol., Jichi Med.Univ., 2Dev.Clin.Pharmacol., Dep.Pharmacol., Jichi Med.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 288-288, 2009.

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P3M-P10-2 Disassembly of the Golgi apparatus under low pH

Nobuhiro Nakamura, Daisuke Tamura, Yuhio Yoneda
Pharmacol, Div Pharm Sci, Kanazawa Univ
Journal of Pharmacological Sciences 109 (suppl.2) 288-288, 2009.

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P3M-P10-3 Ceramidase assay and effect of vanadate on sphingolipid metabolism

Eiko Tada, Hiroyuki Nakamura, Toshihiko Murayama
Grad.Sch.Pharmaceutical Sci., Chiba Univ
Journal of Pharmacological Sciences 109 (suppl.2) 288-288, 2009.

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P3M-P10-4 HRD1 has other functions besides ubiquitin ligase activity

Tomohiro Omura1, Masayuki Kaneko1, Masayuki Onoguchi1, Yasuyuki Nomura2, Yasunobu Okuma1
1Dept.Pharmacol., Faculty of Pharmaceutical Sciences, Chiba Institute of Science, 2Dept.Pharmacotherapeutics, Yokohama College of Pharmacy
Journal of Pharmacological Sciences 109 (suppl.2) 289-289, 2009.

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P3M-P10-5 Human EP3I prostanoid receptor induces VEGF and VEGF receptor-1 mRNA expression

Hiromichi Fujino1, Tomoko Taniguchi1, Davelene.D.Israel2, John.W.Regan2, Toshihiko Murayama1
1Grad.Sch.of Pharmaceutical Sci., Chiba Univ., 2College of Pharmacy, The Univ.of Arizona
Journal of Pharmacological Sciences 109 (suppl.2) 289-289, 2009.

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P3M-P10-6 Methylation and inactivation of estrogen receptor α(ER α)promoter in Chinese women with sporadic breast cancer

Zhao Lin1, Wang Lin1, Jin Feng2, Ma Wenfeng3, Ren Jie1, Wen Xiaoyan1, He Miao1, Sun Mingli1, Tang Hongtao1, Wei Minjie1
1Department of Pharmacology, China Medical University, 2Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, 3Department of General Surgery, The First Affiliated Hospital of China Medical University
Journal of Pharmacological Sciences 109 (suppl.2) 289-289, 2009.

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P3M-P10-7 Histamine-induced down-regulation via clathrin-mediated internalization of histamine H1-receptors in Chinese hamster ovary cells

Hiroshi Komazaki1, Shigeru Hishinuma1, Hiroyuki Fukui2, Masaru Shoji1
1Dept.Pharmacodyn., Meiji Pharm.Univ, 2Dept.Mol.Pharmacol., Grad.Sch.Health Biosci., Univ.Tokushima
Journal of Pharmacological Sciences 109 (suppl.2) 289-289, 2009.

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P3M-P10-8 Identification of novel substrates for Rho-kinase by proteomic screening

Yuuta Tsumura, Kentaro Taki, Hidenori Harada, Mutsuki Amano, Kozo Kaibuchi
Dept.Cell Pharmacol., Nagoya Univ.Sch.Med
Journal of Pharmacological Sciences 109 (suppl.2) 290-290, 2009.

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P3M-P11-1 Functional characterization of choline transporter in human breast cancer

Masato Inazu1, 2, Hirohisa Tajima1, Tomoko Yamada1, Masaaki Hayashi1, Minako Yabuki1, Teruhiko Matsumiya1, 2
1Dept.Pharmacol., Tokyo Med.Univ., 2Dept.Prevent.Med
Journal of Pharmacological Sciences 109 (suppl.2) 290-290, 2009.

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P3M-P11-2 Effect of water extract of Cordyceps sinensis on hepatocyte growth factor-accelerated invasion of B16-mouse melanoma cells

Erika Kubo1, Noriko Yoshikawa1, Yuta Takahashi1, Satomi Kagota2, Kazumasa Shinozuka2, Masaru Kunitomo1, Kazuki Nakamura1
1Dept.of Pharmacol.1, Sch.of Pharm.and Pharmaceu.Sci., Mukogawa Women's Univ., 2Dept.of Pharmacol.2, Sch.of Pharm.and Pharmaceu.Sci., Mukogawa Women's Univ
Journal of Pharmacological Sciences 109 (suppl.2) 290-290, 2009.

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P3M-P11-3 Cancer cells modulate the intracellular macromolecular permeability in the human umbilical vein endothelial cell layer via P2 receptor

Namie Nejime1, Naoko Tanaka2, Satomi Kagota1, Yukari Tada1, Kazuki Nakamura1, Michio Hashimoto3, Masaru Kunitomo1, Kazumasa Shinozuka1
1Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, 2Department of Pharmacology, Kyushu University of Health and Welfare, 3Department of Environmental Physiology, Shimane University Faculty of Medicine
Journal of Pharmacological Sciences 109 (suppl.2) 290-290, 2009.

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P3M-P11-4 EGF receptor regulates volume-regulated anion channel in squamous cell carcinoma cells of HST-1 and A431

Megumi Sugihara1, 2, Miho Matsuda1, Ryosuke Inoue2, Yushi Ito3, Kihachiro Abe2, Masato Hirata1, Hiromitsu Morita2
1Lab.Mol.Cell.Biochem., Fac.of Dent.Sci., Kyushu Univ., 2Special Patient Oral Care Unit of Kyushu Univ.Hosp., 3Dept.Health Sci., Kumamoto Health Sci.Univ
Journal of Pharmacological Sciences 109 (suppl.2) 291-291, 2009.

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P3M-P11-5 Prostaglandin E2 induces vascular endothelial growth factor and its receptor in HCA-7 human colon cancer cells

Kaori Toyomura1, Hiromichi Fujino1, John.W.Regan2, Toshihiko Murayama1
1Grad.Sch.of Pharmaceutical Sci., Chiba Univ., 2College of Pharmacy, The Univ.of Arizona
Journal of Pharmacological Sciences 109 (suppl.2) 291-291, 2009.

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P3M-P11-6 Differentiation-inducing factor-1 suppresses the cyclin D1 expression and inhibits the proliferation of human colon cancer cell lines

Kentaro Jingushi, Fumi Takahashi, Toshiyuki Sasaguri
Dept.Clinical.Pharmacol., Fac.Med.Sci., Kyushu Univ
Journal of Pharmacological Sciences 109 (suppl.2) 291-291, 2009.

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P3M-P11-7 Effect of juglone on cell cycle arrest of human lung adenocarcinoma A549 cells

Zou Xiang, Qu Zhong-Yuan, Kong Ling-Sheng, Ji Yu-Bin
Postdoctal Programme of Institute of Materia Medica of Engineering Research Center of Natural Anticancer Drugs, Ministry of Education, Harbin University of Commerce
Journal of Pharmacological Sciences 109 (suppl.2) 291-291, 2009.

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P3M-P11-8 The Effects of sulfonated chitosans on antiproliferation in human hepatocellular carcinoma cell lines SMCC7721 and its mechanism

Nan-Jin Zhou1, Yong Xie2
1The Medical Institute of Jiangxi, 2The First Affiliated Hospital of Nanchang University
Journal of Pharmacological Sciences 109 (suppl.2) 292-292, 2009.

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