Journal of Pharmacological Sciences 115巻 suppl.1号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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PL Aquaporin water channels：from atomic structure to clinical medicine

Peter Agre
Johns Hopkins Malaria Research Institute, Bloomberg School of Public Health
Journal of Pharmacological Sciences 115 (suppl.1) 2-2, 2011.

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SWSL Control of atrial arrhythmias by microRNAs

Baofeng Yang1, Yanjie Lu1, Ning Wang1, Zhenwei Pan1, Xu Gao2, Hongli Shan1, Chaoqian Xu1
1Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 2Department of Biochemistry, Harbin Medical University
Journal of Pharmacological Sciences 115 (suppl.1) 4-4, 2011.

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ASSL Allosteric and biased signaling of GPCRs： relevance to novel drug discovery

Arthur Christopoulos
Monash Institute of Pharmaceutical Sciences, Monash University
Journal of Pharmacological Sciences 115 (suppl.1) 6-6, 2011.

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SL1 Targeting ALK fusions in human cancer

Hiroyuki Mano1, 2
1Division of Functional Genomics, Jichi Medical University, 2Department of Medical Genomics, Graduate School of Medicine, The University of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 8-8, 2011.

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SL2 Novel mechanisms and treatments of heart failure

Issei Komuro
Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka University
Journal of Pharmacological Sciences 115 (suppl.1) 8-8, 2011.

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SL3 Molecular mechanism and treatment strategy of type 2 diabetes

Takashi Kadowaki
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 8-8, 2011.

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SL4 Prostaglandins and inflammation： a new concept from receptor-KO mouse studies

Shuh Narumiya
Department of Pharmacology, Graduate School of Medicine, Kyoto University
Journal of Pharmacological Sciences 115 (suppl.1) 8-8, 2011.

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SL5 How to improve pharmaceutical research and development productivity： drug target discovery through product development

Masaomi Miyamoto
Research and Development Division, Seikagaku Corporation
Journal of Pharmacological Sciences 115 (suppl.1) 9-9, 2011.

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SL6 Alzheimer's disease： from molecular pathology to disease-modification

Takeshi Iwatsubo
Department of Neuropathology, Graduate School of Medicine, The University of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 9-9, 2011.

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EAL Glutamate receptors and brain function

Masayoshi Mishina
Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 12-12, 2011.

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AL1 Elucidation of molecular mechanism and exploration of novel therapeutics for spinocerebellar ataxia caused by mutant γPKC

Takahiro Seki
Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University
Journal of Pharmacological Sciences 115 (suppl.1) 14-14, 2011.

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AL2 Study on the role of heterotrimetic G protein signaling pathways for the treatment of heart failure

Motohiro Nishida
Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University
Journal of Pharmacological Sciences 115 (suppl.1) 14-14, 2011.

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AL3 Pharmacological study on Alzheimer's drugs targeting for calcium/calmodulin-dependent protein kinase II

Shigeki Moriguchi
Department of Pharmacology, Graduate School of Pharmaceutical, Sciences, Tohoku University
Journal of Pharmacological Sciences 115 (suppl.1) 14-14, 2011.

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SW1-1 Regulation of inflammation process by components from traditional medicinal plants

Hyeong-Kyu Lee, Sei-Ryang Oh, Kyung-Seop Ahn
Bio-Therapeutics Research Inst., Korea Research Inst. of Biosci. & Biotechnology
Journal of Pharmacological Sciences 115 (suppl.1) 16-16, 2011.

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SW1-2 The study of natural medicine for exploring key pathways of neuroregeneration

Chihiro Tohda
Div. of Biofunctional Evaluation, Research Center for Ethnomedicine, Inst. of Natural Med., Univ. of Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 16-16, 2011.

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SW1-3 The role of pharmacology in modernization of traditional Chinese medicine in China

Zhi-Bin Lin
Dept. of Pharmacol., Sch. of Basic Med. Sciences, Peking Univ. Health Sci. Center
Journal of Pharmacological Sciences 115 (suppl.1) 16-16, 2011.

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SW2-1 Metabolomic studies of G6PD-knockdown cells

Daniel Tsun-Yee Chiu, Mei-ling Cheng, Hung-yao Ho
Grad. Inst. of Med. Biotechnology, Chang Gung Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 17-17, 2011.

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SW2-2 Pharmaco-metabonomics： a crystal ball for future?

Huiru Tang
Wuhan Centre for Magnetic Resonance, Wuhan Inst. of Physics and Mathematics, the Chinese Academy of Sciences
Journal of Pharmacological Sciences 115 (suppl.1) 17-17, 2011.

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SW2-3 Pharmacometabolomic study of drug responses

Young-Ran Yoon, Jeonghyeon Park, Jung Ju Seo, Jumi Lee, Prasad B. Phapale, Hae Won Lee, Mi-Sun Lim, Sook Jin Seong
Kyungpook National Univ. Sch. of Med., Dept. of Molecular Med., Clinical Trial Center of Kyungpook National Univ. Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 17-17, 2011.

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SW3-1 Oxidative stress-mediated central circulatory regulatory failure underlies methamphetamine-induced fatal cardiovascular collapse

Alice Y.W. Chang, Samuel H.H. Chan
Center for Translational Research in Biomed. Sciences, Chang Gung Memorial Hosp.-Kaohsiung Med.
Journal of Pharmacological Sciences 115 (suppl.1) 18-18, 2011.

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SW3-2 Pivotal role of oxidative stress within the cardiovascular center in hypertension： angiotensin II and apoptotic signaling Pathway

Yoshitaka Hirooka
Dept. of Cardiovascular Med., Kyushu Univ. Grad. Sch. of Med. Sciences
Journal of Pharmacological Sciences 115 (suppl.1) 18-18, 2011.

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SW3-3 Antioxidants as novel therapeutic targets against neurogenic hypertension

Julie Y.H. Chan, Kay L.H. Wu
Dept. of Med. Education and Research, Kaohsiung Veterans General Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 18-18, 2011.

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SW4-1 Reaction phenotyping and quantitative in vitro - in vivo extrapolation：application to drugs cleared by glucuronidation

John O. Miners
Dept. of Clinical Pharmacol., Flinders Univ. Sch. of Med., Flinders Med.
Journal of Pharmacological Sciences 115 (suppl.1) 19-19, 2011.

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SW4-2 Quantitative prediction of hepatic clearance for anionic drugs based on in vitro experiments

Hiroyuki Kusuhara
Grad. Sch. of Pharmaceutical Sciences, The Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 19-19, 2011.

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SW4-3 Issues in predicting inter-individual variability of pharmacokinetics

Akihiro Hisaka
The University of Tokyo Hospital
Journal of Pharmacological Sciences 115 (suppl.1) 19-19, 2011.

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ASJP-1 ORAI calcium channels and their regulators in breast cancer

Gregory Raymond Monteith
The Univ. of Queensland
Journal of Pharmacological Sciences 115 (suppl.1) 22-22, 2011.

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ASJP-2 TRP channel modulation by small molecules

Yasuo Mori
Dept. of Synthetic Chemistry and Biological Chemistry, Grad. Sch. of Engineering, Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 22-22, 2011.

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ASJP-3 Accelerated biodiscovery of ion channel modulators

Irina Vetter, Richard J. Lewis
Inst. for Molecular Biosci., The Univ. of Queensland, St Lucia
Journal of Pharmacological Sciences 115 (suppl.1) 22-22, 2011.

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JS-1 Circadian clock gene regulation and cardiovascular therapy

Koichi Node
Dept. of Cardiovascular & Renal Med., Saga Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 24-24, 2011.

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JS-2 Implications for drug safety from a drug timing

Shigehiro Ohdo, Satoru Koyanagi, Naoya Matsunaga
Dept. Pharmaceutics, Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 24-24, 2011.

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JS-3 Alleviation of adverse drug reactions by EcoPharma

Ryozo Oishi
Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 24-24, 2011.

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JS-4 Pharmacogenomic approaches for anticipating and avoiding adverse drug reactions

Hirotoshi Echizen
Dept. Pharmacotherapy
Journal of Pharmacological Sciences 115 (suppl.1) 24-24, 2011.

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S1A1-1 Preclinical discovery research of E7820, a novel angiogenesis inhibitor inducing tumor vascular normalization

Taro Semba1, Yasuhiro Funahashi1, 2
1Oncology PCU, Eisai Co., 2BPM-CFU, Eisai Co.
Journal of Pharmacological Sciences 115 (suppl.1) 26-26, 2011.

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S1A1-2 Drug discovery and research of heat shock protein 90 (Hsp90) inhibitor

Shiro Soga1, Takayuki Nakashima1, Toshihiko Ishii2, Yukimasa Shiotsu1, Shiro Akinaga3
1Drug Discovery Research Lab., Kyowa Hakko Kirin, 2Pharmacological Research Lab., Kyowa Hakko Kirin, 3Development Div., Kyowa Hakko Kirin
Journal of Pharmacological Sciences 115 (suppl.1) 26-26, 2011.

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S1A1-3 Progress in research and development of MAPK pathway inhibitors

Yuko Aoki
Research Div. Chugai Co.LTD
Journal of Pharmacological Sciences 115 (suppl.1) 26-26, 2011.

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S1A1-4 R&D approach targeting RTK by c-Met and HER3 signal inhibitors

Kouichi Akahane
Oncol. Res. Lab., Daiichi Sankyo
Journal of Pharmacological Sciences 115 (suppl.1) 26-26, 2011.

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S1B2-1 The metabolic syndrome and homeostatic inflammation

Yoshihiro Ogawa
Dept. Mol. Med. & Metab., Med. Res. Inst., Tokyo Med. Dent. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 27-27, 2011.

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S1B2-2 Role of chronic inflammation in the pathogenesis of atherosclerosis

Masataka Sata
Dept. Cardiovascular Med., Univ. Tokushima. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 27-27, 2011.

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S1B2-3 Cardiac inflammation and heart failure

Tohru Minamino
Dept. of Cardiovasc. Sci. Med., Chiba Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 27-27, 2011.

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S1B2-4 ATP plays a role as a "Danger signal" in atrial fibrillation

Tetsushi Furukawa1, Sakiko Oishi1, Tetsuo Sasano2
1Dept. Bio-Inform. Pharmacol., MRI, Tokyo Med. Dent. Univ., 2MTT Program, MRI, Tokyo Med. Dent. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 27-27, 2011.

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S1C3-1 The basic mechanism of a ketogenic diet： an autocrine regulation via adenosine A1 receptors

Masahito Kawamura1, 2, David N. Ruskin2, Susan A. Masino2
1Dept. Pharmacol., Jikei Univ. Sch. Med., 2Neurosci. Program/Psychology Dept. Trinity Col.
Journal of Pharmacological Sciences 115 (suppl.1) 28-28, 2011.

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S1C3-2 Involvement of adenosine A1 receptors in regulation of axonal conduction of action potentials

Yoshihiko Yamazaki
Dept. Physiol., Yamagata Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 28-28, 2011.

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S1C3-3 Regulation of NMDA receptor functions by Adenosine A1 receptors

Hideki Miwa1, 2
1Dept. Genet and Behav Neurosci., Gunma Univ. Grad. Sch. Med., 2JST CREST
Journal of Pharmacological Sciences 115 (suppl.1) 28-28, 2011.

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S1C3-4 Adenosine A1 receptor regulates metabotropic glutamate receptor signaling and synaptic plasticity in central neurons

Toshihide Tabata1, Yuji Kamikubo2, Yosuke Fujita1, Takeshi Shimomura1, Masahiro Fujino1, Takaaki Miyajima1, Takashi Sakurai2, Kenkichi Fukurotani1, Masanobu Kano3
1Lab. Neural Info. Tech., Grad. Sch. Scis. & Eng., Univ. Toyama, 2Dept. Pharmacol., Juntendo Univ. Sch. Med., 3Dept. Neurophysiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 28-28, 2011.

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S1I4-1 A proteomic approach for comprehensively screening substrates of protein kinases

Mutsuki Amano1, Kozo Kaibuchi1, 2
1Dept. Cell Pharmacol., Nagoya Univ. Sch. Med., 2JST, CREST
Journal of Pharmacological Sciences 115 (suppl.1) 29-29, 2011.

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S1I4-2 Rho signaling in developing nervous system

Dean Thumkeo, Ryota Shinohara, Shuh Narumiya
Dept. Pharmacol., Kyoto Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 29-29, 2011.

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S1I4-3 Regulatory mechanisms of Rac activation by RhoGDI

Takehiko Ueyama1, 2, Jeonghyun Son1, Takeshi Kobayashi2, Naoaki Saito1
1Lab. of Mol. Pharmacol., Biosignal Research Center, Kobe Univ., 2Dept. of Physiol., Nagoya Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 29-29, 2011.

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S1I4-4 An activity map of Rho-family GTPases during cystogenesis

Etsuko Kiyokawa
Dept. Pathol. Biol. Diseases, Kyoto Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 29-29, 2011.

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S1B5-1 Epigenetic signatures of adipose tissue-derived mesenchymal stem cells

Takahiro Ochiya
Div. Mol. Cell Med., Natl Cancer Ctr RI
Journal of Pharmacological Sciences 115 (suppl.1) 30-30, 2011.

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S1B5-2 Stem cells in the adult brain

Kazunobu Sawamoto
Dept. Dev. Regen. Biol., Nagoya City Univ. Grad. Sch. Med. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 30-30, 2011.

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S1B5-3 Is epigenetic modification critical for refractory diseases?

Minoru Narita, Satoshi Imai, Naoko Kuzumaki, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 30-30, 2011.

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S1B5-4 Neurodegenerative disease-specific induced pluripotent stem cell research

Haruhisa Inoue1, 2
1CiRA, Kyoto Univ., 2JST, CREST
Journal of Pharmacological Sciences 115 (suppl.1) 30-30, 2011.

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S1C6-1 Application of fluorescent imaging technology to GPCR ligand screening

Akira Hirasawa1, Takeo Awaji2, Takafumi Hara3, Gozoh Tsujimoto1, 3
1Dept. Genomic Drug Discovery Sci., Grad. Sch. Pharmaceu. Sci. Kyoto Univ., 2Dept. of Pharmacol., Fac. of Med., Saitama Med. Univ., 3WDDC, Grad. Sch. Pharmaceu. Sci. Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 31-31, 2011.

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S1C6-2 Ligand-induced structural rearrangements of G protein coupled receptors revealed by FRET analysis

Michihiro Tateyama, Shinichi Matsushita, Yoshihiro Kubo
Div. Biophysics & Neurobiol., Dept. Mol. Physiol., NIPS
Journal of Pharmacological Sciences 115 (suppl.1) 31-31, 2011.

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S1C6-3 Monomer-dimer dynamic equilibrium of GPCR： direct observation by single molecule imaging

Rinshi S. Kasai1, 2, Kenichi G.N. Suzuki2, 3, Eric R. Prossnitz4, Ikuko Koyama-Honda1, 2, Chieko Nakada1, 2, Takahiro K. Fujiwara1, 2, Akihiro Kusumi1, 2
1Inst. Front. Med. Sci., Kyoto Univ., 2iCeMS, Kyoto Univ., Shogoin, 3PRESTO, JST, 4Dept. of Cell Biology and Physiology, Univ. New Mexico
Journal of Pharmacological Sciences 115 (suppl.1) 31-31, 2011.

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S1C6-4 Induction of cardiac fibrosis by β-blocker in G protein-independent but GRK5/β-arrestin2-dependent signaling pathways

Michio Nakaya, Motohiro Nishida, Hitoshi Kurose
Dept. Pharmacol. Toxicol., Kyushu Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 31-31, 2011.

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S1I7-1 Novel binding of PKCη to RalA and its crucial role in morphological change during keratinocytes differentiation

Yasuhito Shirai1, Naoaki Saito2
1Biosci., Grad. Sch. of Agricultural Sci., Kobe Univ., 2Dept. Mol. Pharmacol., Biosignal Res Ctr, Kobe Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 32-32, 2011.

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S1I7-2 PKCδ as a target molecule of natural resources-derived anti-allergic compounds that suppress up-regulation of allergic diseases sensitive gene expression

Hiroyuki Mizuguchi, Hiroyuki Fukui
Dept. Mol. Pharmacol., Inst. of Health-Biosciences, The Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 32-32, 2011.

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S1I7-3 Possible involvement of protein kinase C-dependent changes in the neuronal activities at the spinal cord on the refractory mechanism of neuropathic pain

Satoshi Imai, Akira Yamashita, Hiroshi Horiuchi, Makoto Yanase, Michiko Narita, Naoko Kuzumaki, Tsutomu Suzuki, Minoru Narita
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 32-32, 2011.

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S1I7-4 Etiology of neuronal diseases induced by the mutation in PKCγ gene

Naoaki Saito, Hideyuki Takahashi
Lab. Mol. Pharm., Biosignal Res. Ctr., Kobe Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 32-32, 2011.

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S1B8-1 Mechanism and management of chemotherapeutic agents-induced peripheral neuropathy

Takehiro Kawashiri1, Yoko Tatsushima1, Nobuaki Egashira1, 2, Ryozo Oishi1, 2
1Grad. Sch. Pharm. Sci., Kyushu Univ., 2Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 33-33, 2011.

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S1B8-2 NK1 receptor antagonist aprepitant： active antiemetic for the prevention of chemotherapy-induced delayed nausea and vomiting

Masaaki Kawahara
Dept. Med. Oncology, KKR Otemae Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 33-33, 2011.

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S1B8-3 Role of TRPV1-positive primary afferent neurons in bone cancer pain

Tomoyuki Kawamata
Dept. Anesth & Resus., Shinshu Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 33-33, 2011.

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S1B8-4 A study that aimed at the treatment of the cancer cachexia with the pharmacological approach

Kiyoshi Terawaki1, Kazuyoshi Yanagihara2, Yumi Sawada1, Masami Suzuki1, Kanako Miyano1, Yuka Sudo1, Seiji Shiraishi1, Yasuhito Uezono1
1Cancer Pathophysiol. Div., NCCRI, 2Dept. of Life Sci., Yasuda Women's Univ. Faculty of Pharmaceutical Sciences
Journal of Pharmacological Sciences 115 (suppl.1) 33-33, 2011.

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S1C9-1 Role of Rab small GTPases in secretory cells

Mitsunori Fukuda
Lab. Membrane Trafficking Mechanisms, Grad. Sch. Life Sci., Tohoku Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 34-34, 2011.

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S1C9-2 Priming calcium-regulated vesicle exocytosis

Thomas F.J. Martin
Dept. of Biochemistry, Univ. of Wisconsin
Journal of Pharmacological Sciences 115 (suppl.1) 34-34, 2011.

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S1C9-3 Modulation of regulated exocytosis by PRIP, a protein phosphatase interacting molecule

Hiroshi Takeuchi, Jing Gao, Zhao Zhang, Goro Sugiyama, Masato Hirata
Lab. Mol. Cell. Biochem., Fac. Dent. Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 34-34, 2011.

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S1C9-4 Molecular mechanisms of insulin granule exocytosis

Tadao Shibasaki1, Harumi Takahashi1, Takao Yasuda1, Chang-Liang Zhang1, Susumu Seino1, 2
1Div. Cell. Mol. Med. Kobe Univ. Grad. Sch. Med., 2Div. Diabetes. Metabolism & Endocrinol. Kobe Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 34-34, 2011.

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S1H10-1 A novel mouse model of obstructive pulmonary disease with mucus accumulation

Tsuyoshi Shuto1, 2, Hirofumi Kai1, 2
1Dept. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ., 2G-COE "Cell Fate Reg. Res. Edu. Unit., Kumamoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 35-35, 2011.

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S1H10-2 Novel type of "knock-in" mouse model for Alzheimer's disease

Takashi Saito, Takaomi Saido
RIKEN Brain Sci. Inst.
Journal of Pharmacological Sciences 115 (suppl.1) 35-35, 2011.

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S1H10-3 Genetic manipulation of nephron progenitors

Ryuichi Nishinakamura
Inst. Mol. Emb. Genet., Kumamoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 35-35, 2011.

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S1H10-4 Establishment of a new mouse model of neurodevelopmental disorder

Tetsuya Taga1, Yuhei Yamaguchi1, Yasuhiro Kokubu1, Satoko Hattori2, 3, Keizo Takao2, Johji Inazawa4, Tsuyoshi Miyakawa2, 3, Tetsushi Kagawa1
1Dept. Stem Cell Regul., Med. Res. Inst., Tokyo Med. & Dent. Univ., 2Centr. Genet. Anal. Behav., Natl. Inst. Physiol. Sci., 3ICMS, Fujita Health Univ., 4Dept. Mol. Cytogenet., Med. Res. Inst., Tokyo Med. & Dent. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 35-35, 2011.

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S1I11-1 Neurogenesis and oligogenesis： their implication and mechanisms

Noriko Osumi
Tohoku Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 36-36, 2011.

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S1I11-2 The role of neural stem cells in neurological and psychiatric diseases

Naoko Kaneko
Dept. Developmental and Regenerative Biol., Nagoya City Univ. Grad. Sch. of Med. Sciences
Journal of Pharmacological Sciences 115 (suppl.1) 36-36, 2011.

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S1I11-3 Molecular mechanism of neural stem cell differentiation associated with aging

Naoko Kuzumaki1, Daigo Ikegami2, Michiko Narita1, Satoshi Imai1, Toshikazu Ushijima2, Tsutomu Suzuki1, Minoru Narita1
1Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Epigenomics Div. Natl. Cancer Ctr. Res. Inst.
Journal of Pharmacological Sciences 115 (suppl.1) 36-36, 2011.

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S1I11-4 Circadian modulation of cognitive performance in BMAL 1KO and AD model mice

Kumiko Ishige1, Yasuhiro Kosuge1, Shigeki Shimba2, Yoshihisa Ito1
1Research unit of Pharmacol., Sch. of Pharm., Nihon Univ., 2Research unit of Health Sci., Sch. of Pharm., Nihon Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 36-36, 2011.

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S1A12-1 Development of a novel antihypertensive agent： a potent and long-lasting angiotensin type1 receptor blocker, TAK-536

Keiji Kusumoto
Pharmacol. Res. Lab, Takeda Pharmaceutical Company Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 37-37, 2011.

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S1A12-2 Pharmacologic strategy for the treatment of resistant hypertension

Kohei Kikkawa
Pharmacol. Res. Lab. II, Mitsubishi Tanabe Pharma Corp.
Journal of Pharmacological Sciences 115 (suppl.1) 37-37, 2011.

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S1A12-3 Combination therapy for antihypertensive patients： focused on end-organ protection

Makoto Mizuno
Biological Research Laboratories, Daiichi Sankyo Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 37-37, 2011.

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S1A12-4 Development of drug for pulmonary arterial hypertension ： a novel therapeutic approach to diseases with enhanced protein phosphorylation

Minoru Seto
Lab. Pharmacol., AsahiKASEI Pharma
Journal of Pharmacological Sciences 115 (suppl.1) 37-37, 2011.

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S1C13-1 Clinical features of acute lung injury and acute respiratory distress syndrome

Satoru Hashimoto
ICU, Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 38-38, 2011.

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S1C13-2 Pathogenesis and therapeutic targets for virus-mediated respiratory failure

Yumiko Imai
Dept. Biological Informatics and Experimental Therapeutics, Akita Univ. Sch. Med
Journal of Pharmacological Sciences 115 (suppl.1) 38-38, 2011.

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S1C13-3 Protection from pulmonary apoptosis： a new therapeutic choice for septic acute lung injury

Ken-ichi Takano1, Hirofumi Oishi2, Yuichi Hattori1
1Dept. of Mol. & Med. Pharmacol., Grad. Sch. of Med. & Pharm. Sci., Univ. of Toyama, 2Dept. of Anesthesiol., Grad. Sch. of Med. & Pharm. Sci., Univ. of Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 38-38, 2011.

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S1C13-4 Alert cell strategy for inflammation and cell death in septic ALI/ARDS

Naoyuki Matsuda
Dept. Emergency & CCM., Nagoya Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 38-38, 2011.

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S1H14-1 Mechanisms of glycine on sleep

Makoto Bannai
Inst. for Innovation, Ajinomoto Co., Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 39-39, 2011.

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S1H14-2 Notable functions of branched chain amino acids as a biological regulator

Fumiaki Yoshizawa
Dept. Bioproductive Sci., Utsunomiya Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 39-39, 2011.

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S1H14-3 Effects of dietary glutamate to gut and brain function

Akihiko Kitamura1, Tomokazu Tsurugizawa1, Akira Uematsu1, Kunio Torii3, Hisayuki Uneyama1, 2
1Nutr. Physiol., Inst. for Innovation, Ajinomoto Co., Inc., 2Umami Wellness, Inst. for Innovation, Ajinomoto Co., Inc., 3Inst. for Innovation, Ajinomoto Co., Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 39-39, 2011.

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S1H14-4 Glutamate protects the small intestine against NSAID-induced damage in rats

Kikuko Amagase, Akimu Ochi, Shinichi Kato, Koji Takeuchi
Dept. Pharmacol. Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 39-39, 2011.

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S1I15-1 Structure and function of vesicular nucleotide transporter (VNUT)

Yoshinori Moriyama
Dept. Membrane Biochem. Okayama Univ. Grad. Sch. Med. Den. Pharmaceutical Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 40-40, 2011.

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S1I15-2 ATP-mediated information transmission downstream of TRP channel activation

Makoto Tominaga1, 2
1Div. Cell Signaling, Okazaki Inst. Integrative Biosci., 2Dept. Physiol. Sci., SOKENDAI
Journal of Pharmacological Sciences 115 (suppl.1) 40-40, 2011.

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S1I15-3 Astrocytic ATP release and brain function

Schuichi Koizumi
Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi
Journal of Pharmacological Sciences 115 (suppl.1) 40-40, 2011.

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S1I15-4 The role of adenosine in sleep-wake regulation

Yoshihiro Urade
Dept. Mol. Behav. Biol., Osaka Biosci. Inst.
Journal of Pharmacological Sciences 115 (suppl.1) 40-40, 2011.

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S2A16-1 Trends in the development of new animal models toward novel drug discovery for schizophrenia

Kazuhito Ikeda
Pharmacol, Research Laboratories, Dainippon Sumitomo Pharma Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 41-41, 2011.

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S2A16-2 Imaging biomarkers in schizophrenia

Satoshi Ozaki
Bioimaging Research Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 41-41, 2011.

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S2A16-3 Next wave-1： group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia

Shigeyuki Chaki1, Shigeru Okuyama2
1Discov. Pharmacol., Mol. Func. Pharmacol. Labs., Taisho Pharmaceutical Co.,Ltd., 2Research Headquaters of Pharmaceutical Operation, Taisho Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 41-41, 2011.

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S2A16-4 Next wave-2： approach for finding novel targets from risk factors of schizophrenia

Takahiko Yano
Pharmacol. research laboratories, PRD, Takeda Pharmaceutical Company
Journal of Pharmacological Sciences 115 (suppl.1) 41-41, 2011.

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S2C17-1 Identification of a novel human renal organic anion efflux related to pharmacological effect and adverse reaction

Promsuk Jutabha, Naohiko Anzai
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 42-42, 2011.

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S2C17-2 Use of the data from genome-wide association study (GWAS) for pharmacogenomics and new drug development： focusing on transporter genes

Naoyuki Kamatani, Taisei Mushiroda
Center Genom. Med., RIKEN
Journal of Pharmacological Sciences 115 (suppl.1) 42-42, 2011.

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S2C17-3 Pharmacogenomics of drug transporters and transporter-mediated drug- and food-drug interactions

Ichiro Ieiri
Dept. Clin. Pharmacokinet., Grad. Sch. Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 42-42, 2011.

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S2C17-4 Confounding factors in drug disposition ： pharmacogenetics of drug transporters

Im Sook Song, Jae-Gook Shin
Dept. of Pharmacol. and Pharmacogenomics Research Center, Inje Univ. College of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 42-42, 2011.

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S2I18-1 Possible control of life span by hibernation hormone, HP complex, activated in the brain

Noriaki Kondo
Tamagawa Univ. Res. Inst.
Journal of Pharmacological Sciences 115 (suppl.1) 43-43, 2011.

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S2I18-2 The roles of vasopressin in the olfactory bulb in anticipation of the drug development

Hirofumi Hashimoto
Centre for Integrative Physiology, College of Med. and Veterinary Med., Univ. of Edinburgh
Journal of Pharmacological Sciences 115 (suppl.1) 43-43, 2011.

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S2I18-3 Receptor for advanced glycation endproducts： a potential target for amyloid-β peptide-mediated neuropathology

Kazuhiro Takuma1, Toshio Matsuda1, 2, Kiyofumi Yamada3
1Lab. Medicinal Pharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Center for Child Mental Dev., United Grad. Sch. Child Dev., Osaka Univ., Kanazawa Univ. and Hamamatsu Univ. Sch. Med., 3Dept. Neuropsychopharmacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 43-43, 2011.

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S2I18-4 New insights into pharmacological potential of plant flavonoids on catecholamine signaling

Nobuyuki Yanagihara1, Han Zhang1, Yumiko Toyohira1, Susumu Ueno1, Masato Tsutsui2, Kojiro Takahashi3
1Dept. Pharmacol., Univ. Occup. & Env. Health, Sch. Med., 2Dept. Pharmacol., Fac. Med. Univ. The Ryukyus, 3Dept. Hos Pharmacy., Univ. Occup. & Env. Health.
Journal of Pharmacological Sciences 115 (suppl.1) 43-43, 2011.

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S2C19-1 Overview： transportsome as a fundamental unit for the onset of diseases

Naohiko Anzai
Dept. Pharmacol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 44-44, 2011.

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S2C19-2 Transportsome in biliary cholesterol secretion

Tappei Takada1, Yoshihide Yamanashi1, 2, Hiroshi Suzuki1
1Dept. of Pharm., Univ. of Tokyo Hosp., 2Pharmacol. and Pharmacokinet., Univ. of Tokyo Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 44-44, 2011.

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S2C19-3 Functional interaction between Na+/Ca2+ exchanger and sodium-transporting proteins in plasmamembrane microdomain

Satomi Kita, Takahiro Iwamoto
Dept. Pharmacol., Facul. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 44-44, 2011.

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S2C19-4 Transportsome in renal tubules

Yumi Noda
Dept. Nephrol. Chronic Kidney Dis.
Journal of Pharmacological Sciences 115 (suppl.1) 44-44, 2011.

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S2H20-1 Immunohistochemical analysis of altered serotonin signaling and transient receptor potential vanilloid (TRPV) 1 channels in experimental colitis mice

Kenjiro Matsumoto, Kimihito Tashima, Syunji Horie
Dept. Pharmacol., Josai Int. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 45-45, 2011.

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S2H20-2 Role of serotonin 5-HT3 receptor in the pathogenesis of IBS with diarrhea

Takuya Hirata, Toshiyuki Funatsu, Yoshihiro Keto, Mayumi Yamano, Toshihide Yokoyama, Shoji Takakura, Keiji Miyata, Nobuo Seki
Appl Pharmacol. Res Labs, Astellas Pharma Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 45-45, 2011.

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S2H20-3 Role of serotonin in regulation of inflammatory responses in the gut

Shinichi Kato, Masashi Yasuda, Narumi Matsuda, Yui Isomoto, Kikuko Amagase, Koji Takeuchi
Div. Pathol. Sci., Dept. Pharmacol. Exp. The., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 45-45, 2011.

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S2H20-4 Stimulation with 5-HT4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus

Masatoshi Hori1, Yasuaki Tsuchida1, 2, Fumihiko Hatao2, Masahiko Fujisawa3, Takahisa Murata1, Yasuyuki Seto2, Hiroshi Ozaki1
1Dept. of Vet. Pharmacol., Grad. Sch. of Agri. and Life Sci., The Univ. of Tokyo, 2Dept. of Gastroint. Surg., Grad. Sch. of Med., The Univ. of Tokyo, 3Dept. of Vet. Sci., Nippon Vet. and Life Sci. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 45-45, 2011.

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S2I21-1 Application of novel in vivo imaging and omics technology in drug discovery

Yuhei Nishimura1, 2, 3, 4, Yasuhito Shimada1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Mol. and Cell. Pharmacol., Pharmacogenomics and Pharmacoinformatics, Mie Univ. Grad. Sch. Med., 2Mie Univ. Med. Zf Res. Cent., 3Dept. of Med. Chemogenomics, Mie Univ. VBL, 4Dept. Bioinfo., Mie Univ. Life Sci. Res. Cent.
Journal of Pharmacological Sciences 115 (suppl.1) 46-46, 2011.

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S2I21-2 Drug discovery and development using omics and molecular imaging technologies

Ryuji Hiramatsu
Genomic Sci. Lab., Dainippon Sumitomo Pharma. Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 46-46, 2011.

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S2I21-3 Innovative drug development by multi-phase application of molecular imaging

Yasuyoshi Watanabe1, 2
1RIKEN Center for Mol. Imag. Sci., 2Dept. Physiol., Osaka City Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 46-46, 2011.

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S2I21-4 mRNA splicing imaging and new therapeutics for RNA diseases

Masatoshi Hagiwara1, Hidehito Kuroyanagi2
1Dept. Anat. & Deve. Biol., Kyoto Univ. Sch. Med., 2Dept. Functional Genomics, Sch. Biomed. Sci., Tokyo Med. & Dent. Univ
Journal of Pharmacological Sciences 115 (suppl.1) 46-46, 2011.

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S2C22-1 Social deficits induced by early postnatal stress

Taku Yamaguchi
Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 47-47, 2011.

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S2C22-2 Npas4 is a stress-responsible transcription factor that regulates neuronal function： implication in neuropsychiatric disorders

Taku Nagai1, 2, Jaesk Yun1, Yoko Furukawa-Hibi1, Kiyofumi Yamada1, 2
1Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 2CREST, JST
Journal of Pharmacological Sciences 115 (suppl.1) 47-47, 2011.

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S2C22-3 Roles of prostaglandin E2 in emotional behavior under acute and chronic stress

Tomoyuki Furuyashiki1, Kohei Tanaka1, Shiho Kitaoka1, 2, Yuta Senzai1, Shuh Narumiya1
1Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med., 2CiRA, Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 47-47, 2011.

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S2C22-4 Pharmacological treatment strategies targeting cognitive impairment associated with aging

Ming Teng Koh
Dept. of Psychological and Brain Sciences, Johns Hopkins Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 47-47, 2011.

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S2H23-1 Hydrogen sulfide： its production, release and function

Hideo Kimura
Dept. Mol. Phrmacol., Natl. Inst. Neurosci. NCNP.
Journal of Pharmacological Sciences 115 (suppl.1) 48-48, 2011.

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S2H23-2 Hydrogen sulphide stimulates gastroduodenal HCO3- secretion

Shusaku Hayashi1, 2, Kikuko Amagase1, Shinichi Kato1, Koji Takeuchi1
1Dept. Pharmacol. Exp. Ther., Kyoto. Pharm. Univ., 2Div. Gastrointest. Pathophysiol., Inst. Natural Med., Univ. Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 48-48, 2011.

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S2H23-3 Hydrogen sulfide production (H2S) and its protective roles in pancreatic beta cells

Ichiro Niki, Shigeki Taniguchi
Dept. Pharmacol., Oita Univ. Faculty Med.
Journal of Pharmacological Sciences 115 (suppl.1) 48-48, 2011.

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S2H23-4 The role of hydrogen sulfide in diabetic nephropathy (DN)

Yukio Yuzawa
Dept. of Nephrology, Fujita Health Univ. Sch. of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 48-48, 2011.

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S2I24-1 Pigs as the preclinical model for medical research

Eiji Kobayashi
CDAMTec. Jichi Med. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 49-49, 2011.

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S2I24-2 Microminipigs： drug oxidation activities in liver microsomes comparable with humans

Hiroshi Yamazaki
Showa Pharma Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 49-49, 2011.

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S2I24-3 Microminipig： potential utility as a tool in safety pharmacology

Yasuki Akie1, 2, Hiroyuki Saito2, Yukitoshi Nagayama2, Yoshiki Tate2, Kiyotaka Hoshiai2, Yuji Nakamura1, Naoki Kaneko3, Katzuhiko Itoh3, Atsushi Sugiyama1
1Dept. Pharmacol., Sch. Med., Fac. Med., Toho Univ., 2SUGI Inst. of Biological Sci. Co., Ltd, 3Fuji Micra Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 49-49, 2011.

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S2I24-4 Microminipig： research models to break through cardiovascular disease

Hiroaki Kawaguchi1, Noriaki Miyoshi2, Naoki Miura3, Masahisa Horiuchi4, Tomoji Ono9, Michiaki Murakoshi8, 9, Hoyoku Nishino8, Ryoichi Nagata10, Hisashi Sahara6, Akihide Tanimoto5, Kazuhiko Yamada6, Hiroki Yoshida7
1Dept. Vet. Exp. Ani. Sci., Agri., Kagoshima Univ., 2Dept. Vet. Pathol., Agri., Kagoshima Univ., 3Dept. Vet. Teaching Hosp., Agri. Kagoshima Univ., 4Dept. Environ. Med., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 5Dept. Mol. and Cell. Pathol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 6Xenotransplantation Surg. Section, FSRC, Kagoshima Univ., 7Kagoshima Univ., 8Kyoto Pref. Univ. of Med., 9Lion Corp., 10SNBL, Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 49-49, 2011.

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S2A25-1 Immunoregulatory molecules reveal crosstalk between immune and pain responses

Kenzo Muramoto
Tsukuba Research Laboratories, Eisai Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 50-50, 2011.

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S2A25-2 Development of an animal model of fibromyalgia-like chronic pain and its use in drug discovery research

Yukinori Nagakura1, Tomoya Oe1, Mina Tsukamoto1, Shinichi Ogino1, Masayasu Takahashi1, Takahisa Noto2, Toshiaki Aoki1
1Dept. Pain Res., Pharmacol. Res. Labs., Astellas Pharma Inc., 2Drug Safety Res. Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 50-50, 2011.

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S2A25-3 Voltage-gated sodium channel blocker for the treatment of neuropathic pain

Shuzo Watanabe
RaQualia Pharma Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 50-50, 2011.

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S2A25-4 TRP channel ligands as novel analgesics for neuropathic pain

Tatsuya Kamei, Masanori Miyauchi, Yoshihiro Oyamada, Isao Shimizu
Pharmacol. Research Lab., Dainippon Sumitomo Pharma Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 50-50, 2011.

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S2C26-1 Development of pet probes for imaging biomarker

Shozo Furumoto
Dept. Pharmacol., Tohoku Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 51-51, 2011.

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S2C26-2 Development of pre-clinical PET system

Katsumi Sekikawa
Shimadzu corporation
Journal of Pharmacological Sciences 115 (suppl.1) 51-51, 2011.

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S2C26-3 Brain imaging in laser-induced ocular hypertensive monkeys using PET and MRI

Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol. Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 51-51, 2011.

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S2C26-4 Role of bioimaging technology to drug discovery research

Shintaro Nishimura
Bioimaging Res. Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 51-51, 2011.

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S2H27-1 Alternatives to animal experiments in pharmacology

Yasuo Ohno
Nat. Inst. Health Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 52-52, 2011.

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S2H27-2 Current status of alternative testing in Japan

Hajime Kojima
JaCVAM, NIHS
Journal of Pharmacological Sciences 115 (suppl.1) 52-52, 2011.

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S2H27-3 Asian research trends in alternatives to animal experimentation

Tsutomu Kurosawa
Dept. of Laboratory Animal Med., Osaka Univ. Med. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 52-52, 2011.

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S2H27-4 Development of short-term in vitro testing systems for hazardous chemicals by NEDO

Noriho Tanaka
Div. Alternative Res. Hatano Res. Inst., Food & Drug Safety Ctr.
Journal of Pharmacological Sciences 115 (suppl.1) 52-52, 2011.

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S2I28-1 Nipkow-disk confocal microscopy towards neuronal networks at work

Takuya Sasaki1, 2, Norio Matsuki1, Yuji Ikegaya1
1Lab. Chem. Pharmacol., Grad. Sch. Pharm., Tokyo Univ., 2Saitama Univ., BSI
Journal of Pharmacological Sciences 115 (suppl.1) 53-53, 2011.

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S2I28-2 Neural functions revealed by new methods of chemical biology and optogenetics

Masanori Matsuzaki1, 2
1Div. Brain Circuits, National Inst. for Basic Biology, 2SOKENDAI
Journal of Pharmacological Sciences 115 (suppl.1) 53-53, 2011.

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S2I28-3 Membrane potential dynamics in neurons probed by the second harmonic generation imaging

Mutsuo Nuriya, Masato Yasui
Dept. Pharmacol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 53-53, 2011.

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S2I28-4 Imaging mass spectrometry (IMS)： a novel imaging tool to visualize the spatial distribution of drug in whole-body sections

Mitsutoshi Setou1, Yusuke Saito1, Takahiro Hayasaka1, Kenji Onoue1, Yoshinori Takizawa2
1Dept. Mol. Anat. Hamamatsu Univ. Sch. Med., 2Dept. Otolaryngol. Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 53-53, 2011.

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S3A29-1 Biomarker development in drug discovery and development

Akira Shinagawa
Clin. Pharm & Transl. Med. Dept., R&D Div., Daiichi-Sankyo Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 54-54, 2011.

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S3A29-2 Application of microdose clinical studies to drug discovery and development： to improve the probability of success of development process

Yoshiyuki Yamaura
Discovery Technology Lab., ONO Pharmaceutical. Co.,Ltd
Journal of Pharmacological Sciences 115 (suppl.1) 54-54, 2011.

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S3A29-3 Moving Pharmacogenomics into clinical practices

Shyh-Yuh Liou
Clinical Data Sci. Dept, Japan Develop. Center, Pharm. Develop. Div. Takeda Pharm. Co.Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 54-54, 2011.

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S3A29-4 Application of bioimaging technology to translational research

Shintaro Nishimura
Bioimaging Res. Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 54-54, 2011.

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S3B30-1 Overview of ion channels as a target for drug discovery and novel screening methods

Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 55-55, 2011.

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S3B30-2 Voltage-sensing Phosphatase： mechanisms and applications

Yasushi Okamura
Grad. Sch. of Med., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 55-55, 2011.

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S3B30-3 Automated planar patch clamp-accelerating ion channel drug discovery

Martin Gosling
Respiratory Disease Area, Novartis Inst. of Biomed. Research
Journal of Pharmacological Sciences 115 (suppl.1) 55-55, 2011.

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S3B30-4 An automated electrophysiological system for the measurement of transporter/channel activities

Shuji Kaneko
Dept. Mol. Pharmacol., Kyoto Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 55-55, 2011.

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S3C31-1 Osteonetwork and its application to drug discovery

Shu Takeda
Dept. Internal Med., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 56-56, 2011.

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S3C31-2 New drug targets from the viewpoint of osteoimmunology

Tomoki Nakashima1, 2, Hiroshi Takayanagi1, 2
1Dept. Cell Signal., TMDU, 2JST, ERATO, Takayanagi Osteonetwork Project
Journal of Pharmacological Sciences 115 (suppl.1) 56-56, 2011.

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S3C31-3 Selective inhibition of NF-кB enhances BMP-induced bone formation

Eijiro Jimi
Div. of Molecular Signaling and Biochemistry, Kyushu Dental College
Journal of Pharmacological Sciences 115 (suppl.1) 56-56, 2011.

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S3C31-4 Regulatory mechanisms of RANKL subcellular localization as possible therapeutic targets

Masashi Honma
Dept. Pharm., The Univ. Tokyo Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 56-56, 2011.

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S3I32-1 Chemokine-mediated migration control of bone cells visualized by intravital multiphoton bone imaging

Masaru Ishii, Junichi Kikuta, Atsuko Kubo, Yutaka Shimazu
Lab. Biol. Imaging, Osaka Univ. IFReC
Journal of Pharmacological Sciences 115 (suppl.1) 57-57, 2011.

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S3I32-2 Development of imaging probe specific to hypoxia inducible transcription factor HIF

Shinae Kondoh
Dept. Biomolecular Engineering
Journal of Pharmacological Sciences 115 (suppl.1) 57-57, 2011.

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S3I32-3 In vivo molecular imaging reveals parenchymal and interstitial cell cross-talks in chronic inflammatory diseases

Satoshi Nishimura1, 2, 3
1Dept. of Cardiovasc. Med., The Univ. of Tokyo, 2PRESTO, Japan Sci. and Technology Agency, 3TSBMI, The Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 57-57, 2011.

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S3C33-1 Anti-high mobility group box1 monoclonal antibody ameliorates brain infarction

Hideo Takahashi1, Shuji Mori2, Masahiro Nishibori1
1Dept. Pharmacol., Okayama Univ. Grad. Sch. Med., Dent. & Pharm. Sci., 2Dept. Pharmacy, Shujitsu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 58-58, 2011.

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S3C33-2 Therapeutic potential of non-psychotropic cannabidiol in ischemic stroke

Kazuhide Hayakawa1, 2, Kenichi Mishima1, Eng H. Lo2, Katsunori Iwasaki1, Michihiro Fujiwara1
1Dept. Neuropharmacol., Fukuoka Univ., 2MGH-Harvard
Journal of Pharmacological Sciences 115 (suppl.1) 58-58, 2011.

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S3C33-3 Prothymosin α： a novel neuroprotetive polypeptide against ischemic damages

Hiroshi Ueda, Hayato Matsunaga
Div. Mol. Pharmacol. & Neurosci., Nagasaki Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 58-58, 2011.

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S3C33-4 Understanding the mechanisms of actions of neuroprotective compounds in animal stroke models

Kazuya Hokamura, Kazuo Umemura
Dept. Pharmacol, Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 58-58, 2011.

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S3I34-1 The emerging roles of prostaglandin E receptor in immune inflammation

Daiji Sakata1, Chengcan Yao1, Yoshiyasu Esaki1, 2, Youxian Li1, Toshiyuki Matsuoka1, Kenji Kuroiwa3, Yukihiko Sugimoto3, Shuh Narumiya1
1Dept. of Pharmacol., Faculty of Med., Kyoto Univ., 2Dept. of Anesthesiol. Faculty of Med, Kyoto Univ., 3Dept. of Physiol. Chem., Grad. Sch. of Pharmaceut. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 59-59, 2011.

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S3I34-2 Characterization of the recognition mechanisms of the bitter taste receptor

Takumi Misaka
Dept. Appl. Biol. Chem., Univ. Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 59-59, 2011.

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S3I34-3 Towards structure determination for G protein-coupled receptor

Takuya Kobayashi1, 2, Mitsunori Shiroishi2, Tatsuro Shimamura2, Takami Yurugi2, Hidetsugu Asada2, Tomoya Hino2, Takatoshi Arakawa2, Takeshi Murata2, Norimichi Nomura1, 2, So Iwata1, 2
1Dept. Cell Biology, Kyoto Univ., 2JST ERATO Iwata Human Receptor Crystallography Project
Journal of Pharmacological Sciences 115 (suppl.1) 59-59, 2011.

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S3C35-1 Novel treatment for sensorineural hearing loss using inner ear drug delivery system

Takayuki Nakagawa
Dept. Otolaryngol., Grad. Sch. Med., Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 60-60, 2011.

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S3C35-2 Gene therapy for inner ear diseases

Sho Kanzaki
Dept. Otorhinolaryngology, Head and Neck Surgery, Keio Univ., Sch. of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 60-60, 2011.

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S3C35-3 Cell therapy for heredity deafness with bone marrow mesenchymal stem cell

Kazusaku Kamiya, Kana Ogawa, Hiromi Kasagi, Katsuhisa Ikeda
Dept. of Otorhinolaryngol., Juntendo Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 60-60, 2011.

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S3C35-4 Mechanosensitive hair cell-like cells from embryonic and induced pluripotent stem cells

Kazuo Oshima, Stefan Heller
Dept. Otolaryngol., Stanford Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 60-60, 2011.

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S3I36-1 Novel chemical fluorescence sensors for visualization of various ROS in living cells and animals

Yasuteru Urano
Grad. Sch. of Med., The Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 61-61, 2011.

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S3I36-2 Elucidation of the functions of endogenous nitrated nucleotides using chemical probes

Hirokazu Arimoto
Tohoku Univ. Grad. Sch. Life Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 61-61, 2011.

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S3I36-3 Importance of H2O2 generation and protein oxidation in Semaphorin3A signaling

Hiroaki Miki, Akifumi Morinaka, Yosuke Funato
Inst. Prot. Res., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 61-61, 2011.

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S3I36-4 Reactive oxygen species inhibits nitric oxide-mediated signaling pathway for synaptic plasticity

Sho Kakizawa
Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 61-61, 2011.

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O1D1-E-1 Insulin treatment prevents renal senescence in diabetes

Kento Kitada, Daisuke Nakano, Hirofumi Hitomi, Akira Nishiyama
Dept. Pharmacol., Kagawa Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 64-64, 2011.

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O1D1-E-2 Mechanism of the onset of diabetic nephropathy in type 2 diabetic db/db mice (3rd report)

Nana Iwakawa, Makoto Hosoyamada, Yuichi Takiue, Masaki Kimura, Hidetsugu Saito
Div. Pharmacotherapeutics, Keio Univ. Faculty of Pharmacy
Journal of Pharmacological Sciences 115 (suppl.1) 64-64, 2011.

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O1D1-E-3 Suppression of pathological retinal angiogenesis by siRNA targeting apelin

Atsushi Kasai1, Yuki Ishimaru1, Fumi Gomi2, Yasuhiro Yoshioka1, Akiko Yamamuro1, Sadaaki Maeda1
1Dept. Pharmacotherap., Fac. Pharm. Sci., Setunan Univ., 2Dept. Ophthalmol., Grad. Sch. Med., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 64-64, 2011.

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O1D1-E-4 Exploring novel calmodulin-related proteins which mediate vascular diseases

Tatsuya Usui, Hideyuki Yamawaki, Muneyoshi Okada, Yukio Hara
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 64-64, 2011.

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O1D1-E-5 Resveratrol, a SIRT1 activator, inhibits muscle fibrosis in mdx mouse

Yusuke Hori1, Atsushi Kuno1, 2, Ryusuke Hosoda1, Yoshiyuki Horio1
1Dept. Pharmacol., Sapporo Med. Univ. Sch. Med., 2Dept. 2nd. Int. Med., Sapporo Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 65-65, 2011.

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O1D2-E-1 MEK/ERK and C/EBPα are involved in IL-1β-induced decrease in aquaporin-3 in lung epithelial cells

Ichiro Horie, Akinori Hisatsune, Hiroshi Katsuki, Yoichiro Isohama
Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 65-65, 2011.

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O1D2-E-2 Mast cells regulate IL-4 production in iNKT cells by physical interaction

Daisuke Kurihara, Nobuyuki Fukuishi, Hayato Teruya, Nobuaki Matsui, Masaaki Akagi
Dept. Pharmacol., Tokushima Bnri Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 65-65, 2011.

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O1D2-E-3 Comparative efficacy in models of autoimmune arthritis by tyrosine kinase inhibitors imatinib and nilotinib

Naotsugu Akashi1, 2, Isao Matsumoto1, Yoko Tanaka1, Asuka Inoue1, Kayo Yamamoto1, Naoto Umeda1, Yuki Tanaka1, Taichi Hayashi1, Daisuke Goto1, Kaneo Sekiguchi2, Takayuki Sumida1
1Dept. Clin Immun., Grad. Sch. Compre. Hum. Sci., Tsukuba Univ., 2Dept. TS, Div. Dev., Novartis, Translational Sciences Dept., Development Div., Novartis Pharma K.K.
Journal of Pharmacological Sciences 115 (suppl.1) 65-65, 2011.

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O1D2-E-4 Intravenous immunoglobulin inhibits autoantibody production by B-1 cells

Jun Tanaka1, 2, Atsushi Nakano2, Yumi Itoh1, Toshiyuki Takai1
1Dept. Exp. Imuun., Tohoku Univ. IDAC, 2Pharmacol., Benesis Osaka Labo.
Journal of Pharmacological Sciences 115 (suppl.1) 66-66, 2011.

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O1D2-E-5 Nanoparticle therapy -Nitroxyl radicals in nanoparticle scavenge ROS in ischemia reperfusion injury-

Yukio Nagasaki1, 2, 3
1Dept. Mat., Univ. Tsukuba, 2Dept. Med. Sci., Univ. Tsukuba, 3MANA, NIMS
Journal of Pharmacological Sciences 115 (suppl.1) 66-66, 2011.

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O1D3-E-1 Therapeutic effect of PC-SOD on pulmonary emphysema

Ken-ichiro Tanaka, Tohru Mizushima
Dept. Microbiol., Kumamoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 66-66, 2011.

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O1D3-E-2 Additive potentiating effects of genistein and curcumin on an ABC transporter CFTR with a disease-associated mutation

Ying-Chun Yu1, Haruna Miki2, 3, Yumi Nakamura1, 2, Yohei Matsuzaki1, Yoichiro Abe1, Kazuhiko Tanaka3, Tzyh-Chang Hwang2, Silvia Bompadre2, Masato Yasui1, Yoshiro Sohma1, 2
1Dept. Pharmacol., Keio Univ. Sch. Med., 2John M. Dalton Cardiovasc. Res. Center, Univ. Missouri-Columbia, 3Dept. Clin. Pharm., Osaka Univ. Pharmaceu. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 66-66, 2011.

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O1D3-E-3 Role of prostaglandin I2 in nonalcoholic steatohepatitis

Shima Kumei1, 2, Koh-ichi Yuhki1, Fumiaki Kojima1, Hitoshi Kashiwagi1, Toshikatsu Okumura2, Shuh Narumiya3, Fumitaka Ushikubi1
1Dept. Pharmacol., Asahikawa Med. Univ., 2Dept. General Med., Asahikawa Med. Univ., 3Dept. Pharmacol., Kyoto Univ. Fac. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 67-67, 2011.

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O1D3-E-4 Pathogenic role of NADPH oxidase 1 (Nox1) in 5-fluorouracil-induced intestinal mucositis in mice

Masashi Yasuda1, Shinichi Kato1, Kuniharu Matsuno2, Kazumi Iwata2, Kikuko Amagase1, Chihiro Yabe2, Koji Takeuchi1
1Dept. Pharmacol. Exp. Ther., Kyoto Pharm. Univ., 2Dept. Pharmacol., Kyoto Pref. Univ. of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 67-67, 2011.

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O1D3-E-5 Streptococcus mutans aggravates inflammation in DSS-induced colitis mice

Ayuchi Kojima1, 2, Koichiro Wada1, Kazuhiko Nakano2, Takashi Ooshima2, Yoshinori Kamisaki1
1Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ., 2Dept. Pediatric Dent., Grad. Sch. Dent., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 67-67, 2011.

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O1D4-E-1 The role of histamine H3 receptor in pancreatic β-cells

Tadaho Nakamura1, Takeo Yoshikawa1, Naoya Noguchi2, Kazuhiko Yanai1, 3
1Dept. Pharmacol., Tohoku Univ. Sch. Med., 2Dept. Otorhio., Tohoku Univ. Sch. Med., 3CYRIC, Tohoku Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 67-67, 2011.

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O1D4-E-2 Positive and negative regulation of insulin receptor signaling in adrenal chromaffin cells

Takayuki Nemoto1, Toshihiko Yanagita1, Akihiko Wada2, Manabu Murakami1
1Dept. Pharmacol., Miyazaki Med. Coll., Univ. Miyazaki, 2Dept. Sports Health and Welfare, Social Welfare, Kyushu Univ. Hlth. Welfare
Journal of Pharmacological Sciences 115 (suppl.1) 68-68, 2011.

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O1D4-E-3 Critical structural property of leucine to activate amino acid signaling via transporters

Pattama Wiriyasermkul1, 2, Shushi Nagamori1, Toru Kimura2, Ryuichi Ohgaki1, Yoshikatsu Kanai1
1Div. of Biosystem Pharmacol., Dept. of Pharmacol., Grad. Sch. of Med., Osaka Univ., 2Dept. of Pharmacol. and Toxicol., Grad. Sch. of Med., Kyorin Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 68-68, 2011.

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O1D4-E-4 Interaction of the multivalent PDZ proteins with sodium-phosphate transporter 4 (NPT4)

Toshiyuki Fukutomi, Naohiko Anzai, Promsuk Jutabha, Yohikatsu Kanai, Hiroyuki Sakurai
Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 68-68, 2011.

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O1D4-E-5 Enhancement of adipogenesis induced by RU486(Mifepristone) is associated with perturbed expression patterns of cell-cycle proteins, p27kip, and Cyclin B1/D1/E

Takeshi Hashimoto1, Junsuke Igarashi1, Yukiko Nagai2, Tetsuo Yamashita1, Hiroaki Kosaka1
1Dept. of Cardiovascular Physiology, Faculty of Med., Kagawa Univ., 2Life Sci. Research Center, Kagawa Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 68-68, 2011.

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O1D4-E-6 ATP-induced inositol 1, 4, 5-trisphosphate signaling in Schwann cells is required for myelination

Daisuke Ino1, Kazunori Kanemaru1, Yohei Okubo1, Kuniaki Ishii2, Masamichi Ohkura3, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo, 2Dept. Cardiovasc. Pharmacol., Yamagata Univ. Sch. Med., 3Brain Res. Inst., Saitama Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 69-69, 2011.

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O1E1-E-1 Another pathway to produce hydrogen sulfide in the brain

Narihiro Shibuya1, Mari Ishigami2, Makiko Tanaka1, Yuka Kimura1, Yuki Ogasawara3, Hideo Kimura1
1Dept. Mol. Pharm., Natl. Inst. Neurosci., NCNP, 2Grad. Sch. Biomed. Sci., Tokyo Med. and Dental Univ., 3Dept. Hygienic Chemistry, Meiji Pharm. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 69-69, 2011.

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O1E1-E-2 Effect of angiotensin II type 2 receptors on NGF-mediated neurite outgrowth in apoE knockout mice

Narumi Hashikawa1, Naoya Hashikawa1, Chikao Yutani1, Yoshito Zamami2, Shingo Takatori2, Mitsunobu Mio3, Hiromu Kawasaki2
1Dept. Life Sci., Grad. Sci., Okayama Univ. Sci., 2Dept. Clin. Pharmac. Sci., Grad. Sch. Med. Dent. Pharmaceut. Sci., Okayama Univ., 3Dept. Clin. Pharmc. Shujitsu Univ. Sch. Pharmac.
Journal of Pharmacological Sciences 115 (suppl.1) 69-69, 2011.

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O1E1-E-3 The deficiency of histamine H3 receptor increases the sensitivity of morphine-induced hyperlocomotion without affecting the reward in mice

Dongying Zhang1, 2, Fumito Naganuma1, Takeo Yoshikawa1, Tadaho Nakamura1, Attayeb Mohsen1, Kazuhiko Yanai1
1Dept. Pharmacol., Tohoku Univ. Sch. Med., 2Dept. Anesthesiol., First Hosp. China Med Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 69-69, 2011.

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O1E1-E-4 Stoichiometry of GluRδ2-Cbln1-Neurexin1β triad

Sung-Jin Lee, Takeshi Uemura, Masayoshi Mishina
Dept. of Mol. Neurobiol. & Pharmacol., Grad. Sch. of Med., Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 70-70, 2011.

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O1E1-E-5 Information content of a presynaptic terminal revealed by glutamate imaging

Hirokazu Sakamoto1, 2, Shigeyuki Namiki1, Kenzo Hirose1
1Dept. Neurobiol., Univ. Tokyo. Sch. Med., 2Dept. Cellphysiol., Nagoya Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 70-70, 2011.

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O1E1-E-6 Large-scale spine imaging reveals clustered and dispersed patterns of synaptic inputs over dendrites

Naoya Takahashi1, Norio Matsuki1, Yuji Ikegaya1, 2
1Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Univ. Tokyo, 2PRESTO
Journal of Pharmacological Sciences 115 (suppl.1) 70-70, 2011.

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O1E2-E-1 Role of IFITM3 in brain dysfunction induced by neonatal immune activation

Daisuke Ibi1, Taku Nagai1, Akira Nakajima1, Toshitaka Nabeshima2, Kiyofumi Yamada1
1Dept Neuropsychopharmacol & Hosp pharm, Nagoya Univ Grad Sch Med, 2Dept Chem Pharmacol, Meijo Univ Grad Sch of Pharm Sci
Journal of Pharmacological Sciences 115 (suppl.1) 70-70, 2011.

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O1E2-E-2 Different actions of galantamine and donepezil on M1 muscarinic receptors contribute to their effects on prepulse inhibition deficits of isolation-reared mice

Ken Koda1, Yukio Ago1, Koji Yano1, Asako Fukada1, Tetsuaki Nashida1, Yuki Ota1, Kazuhiro Takuma1, Toshio Matsuda1, 2
1Lab. Medicinal Pharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Center for Child Mental Dev., Grad. Sch. Med., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 71-71, 2011.

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O1E2-E-3 KNT-127, a newly synthesized opioid-delta receptor agonist, produced antidepressant-like and antinociceptive effects, without epileptogenic effect in mice

Azusa Sugiyama1, 2, Akiyoshi Saitoh1, 2, Toru Nemoto3, Hideaki Fujii3, Jun-ichiro Oka2, Mitsuhiko Yamada1, Hiroshi Nagase3
1Dept. of Neuropsychopharmacology, National Inst. of Mental Health, National Center of Neurology and Psychiatry, 2Laboratory of Pharmacol., Faculty of Pharmaceutical Sciences, Tokyo Univ. of Sci., 3Laboratory of Med. Chemistry, Sch. of Pharmacy, Kitasato Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 71-71, 2011.

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O1E2-E-4 Possible involvement of histone acetylation on the development of emotional resistance to stress stimuli mediated by 5-HT1A receptors in mice

Kazuya Miyagawa, Minoru Tsuji, Kanji Fujimori, Yasuho Saito, Hideaki Kato, Hiroshi Takeda
Div. Pharmacol., Sch. Pharm., Internat. Univ. Health and Welfare
Journal of Pharmacological Sciences 115 (suppl.1) 71-71, 2011.

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O1E2-E-5 A novel role of NOX1/NADPH oxidase in stress-induced anxiety

Hirosuke Uchimaki, Masakazu Ibi, Kuniharu Matsuno, Chihiro Yabe-Nishimura
Dept. Pharmacol., kyoto pref. Univ. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 71-71, 2011.

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O1E2-E-6 Involvement of histamine H1 receptors and hypothalamic AMPK on olanzapine-induced glucose intolerance in mice

Megumi Asato1, Yoko Ishikawa1, Masahiro Ohsawa1, Atsuko Kamei2, Hiroko Ikeda1, Junzo Kamei1
1Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Mine Pharmacy
Journal of Pharmacological Sciences 115 (suppl.1) 72-72, 2011.

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O1E3-E-1 The combination of argatroban and vitamin C normalizes the increased vascular reactivity after subarachnoid hemorrhage (SAH)

Katsuharu Kameda1, 2, Yuichiro Kikkawa1, 2, Mayumi Hirano1, Tomio Sasaki2, Katsuya Hirano1
1Div. Mol. Cardiol., Grad. Sch. Med. Sci., Kyushu Univ., 2Dep. Neursurg., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 72-72, 2011.

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O1E3-E-2 Effect of orexin-A on post-ischemic glucose intolerance and the ischemic neuronal damage

Shinichi Harada, Wakako Fujita-Hamabe, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobegakuin Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 72-72, 2011.

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O1E3-E-3 Up-regulation of MIP-2 and its receptor through histone acetylation involves in nerve injury-induced neuropathic pain

Norikazu Kiguchi, Takehiko Maeda, Yuka Kobayashi, Shiroh Kishioka
Dept. Pharmacol., Wakayama Med. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 72-72, 2011.

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O1E3-E-4 P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury

Hidetoshi Tozaki-Saitoh1, Mitsuyo Maeda2, Makoto Tsuda1, Hiroshi Kiyama2, Kazuhide Inoue1
1Dept. Mol. Sys. Phamacol., Grad. Sch. Pharmceut. Sci., Kyushu Univ., 2Dept. Anatomy and Neurobiology, Grad. Sch. Med., Osaka City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 73-73, 2011.

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O1E3-E-5 Mouse model of bortezomib-induced peripheral neuropathy and the effects of analgesics and analgesic adjuvant

Ryo Kitamura, Tsugunobu Andoh, Shizuka Mizoguchi, Yasushi Kuraishi
Dept. Applied Pharmacol., Toyama Univ. Sch. Pharm
Journal of Pharmacological Sciences 115 (suppl.1) 73-73, 2011.

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O1E3-E-6 Involvement of TRPA1 in oxaliplatin-induced peripheral neuropathy

Meng Zhao
Dept. Mol. Pharmacol., Grad. Sci. Pharmaceu. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 73-73, 2011.

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O1E4-E-1 High-content analysis of tumor angiogenesis in novel human cancer transplantation model

Junya Kuroyanagi1, Yasuhito Shimada1, 2, 3, 4, Yuhei Nishimura1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Pharmacogenomics., Mie Univ. Sch. Med., 2Mie Univ. Med. Zebrafish Research Center, 3Dept. of Bioinformatics, Mie Univ. Life Sci. Research Center, 4Dept. of Med. Chemogenomics, Mie Univ. Venture Business Laboratory
Journal of Pharmacological Sciences 115 (suppl.1) 73-73, 2011.

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O1E4-E-2 The inhibitory mechanisms of nerve growth factor (NGF) in mouse tumor growth

Shingo Takatori1, Satoko Fukuhara1, Mitsuhiro Goda2, Narumi Hashikawa3, Yoshito Zamami4, Hiromu Kawasaki1
1Dept. Clin. Pharmac. Sci., Grad. Sch. Med. Den. Pharmac. Sci., Okayama Univ., 2Div. Pharmacol. Niigata Univ. Grad. Sch. Med. Dent. Sci., 3Dept. life Sci., Okayama Univ of Sci., 4Dept. Mol. Des. Med., Grad. Sch. Med. Den. Pharmac. Sci., Okayama Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 74-74, 2011.

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O1E4-E-3 Stereoselective disposition of S- and R-［6]-gingerol in mice after oral administration

Mayumi Okamoto1, Keigo Kamikihara1, Hiroyuki Irii1, Yu Tahara2, Akiko Hirao2, Shigenobu Shibata2, Isao Shimizu1
1Dept. Appl. Chem., Sch. of Advanced Sci. and Eng., WASEDA Univ., 2Dept. Physiol. and Pharmacol., Sch. of Advanced Sci. and Eng., WASEDA Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 74-74, 2011.

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O1E4-E-4 Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells

Han Zhang1, Yumiko Toyohira1, Susumu Ueno1, Hideaki Itoh1, Masato Tsutsui2, Tohru Yamakuni3, Kojiro Takahashi4, Nobuyuki Yanagihara1
1Dept. Pharmacol., UOEH Univ. Sch. Med., 2Dept. Pharmacol., Sch. Med., Fac. Med., Univ. Ryukyus., 3Grad. Sch. Pharmaceu. Sci., Tohoku Univ., 4Dept. Hos Pharmacy., Univ. Occup. Environ. Health.
Journal of Pharmacological Sciences 115 (suppl.1) 74-74, 2011.

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O1E4-E-5 Ameliorative effects of Yokukansan on learning and memory deficits in olfactory bulbectomized mice used as an Alzheimer disease model

Marina Yamada1, Miki Hayashida1, Qi Zhao1, Naotoshi Shibahara2, Takeshi Miyata3, Kinzo Matsumoto1
1Div. Medicinal Pharmacol., Inst. Natural Med., Univ. Toyama, 2Dept. Kampo Diagnostics., Inst. Natural Med., Univ. Toyama, 3Dept. Presymptomatic Med. Pharmacol., Sojo Univ
Journal of Pharmacological Sciences 115 (suppl.1) 74-74, 2011.

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O1F1-J-1 Laser-induced selective thrombolysis without vessel damage in the rat thrombosis models

Yuji Matsumoto1, Daisuke Yamashita2, Yutaka Yamashita2, Yoshiyuki Shimizu2, Hiroyuki Okada2, Teiji Nakayama3, Kazuya Hokamura1, Ayami Hori1, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2Cent. Res. Lab., Hamamatsu Photonics K.K., 3Dept. Neurosurg., Hamamatsu Med. Center
Journal of Pharmacological Sciences 115 (suppl.1) 75-75, 2011.

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O1F1-J-2 Liposome-encapsulated hemoglobin ameliorates fear memory and hippocampal dysfunction after transient cerebral ischemia in rats

Naobumi Hamadate1, Taku Yamaguchi1, Aya Sugawara1, Hiroko Togashi2, Takeshi Izumi1, Takayuki Yoshida1, Yu Ohmura1, Mitsuhiro Yoshioka1
1Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med., 2Dept. Pharmacol., Fac. Pharm. Sch., Hlth. Sci. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 75-75, 2011.

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O1F1-J-3 Neurosteroid, DHEA inhibits ischemia-induced neuronal death through sigma-1 receptor stimulation

Tatsuya Ikuno, Norifumi Shioda, Kohji Fukunaga
Dept. Pharmacol. Tohoku Univ. Grad. Sch. Pharm. Scis.
Journal of Pharmacological Sciences 115 (suppl.1) 75-75, 2011.

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O1F1-J-4 Capsaicin reduces neuronal cell death in the ischemic-reperfused rat retina

Taiyo Kuroki, Asami Mori, Tsutomu Nakahara, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 75-75, 2011.

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O1F1-J-5 Pathophysiological role of ADAMTS13 in ischemic injury after transient focal cerebral ischemia

Takafumi Nakano1, Kazuhide Hayakawa1, Masayuki Fujioka1, 2, Keiichi Irie1, Sei Higuchi1, Yoshiharu Akitake1, Keisuke Kawasaki1, Masayuki Tamano1, Kenichi Mishima1, Katunori Iwasaki1, Michihiro Fujiwara1
1Dept. Neuropharmacology, Fukuoka Univ. Sch. Phrma. sci., 2Dept. Emergency and Critical Care Med., Nara Med. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 76-76, 2011.

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O1F1-J-6 Microarray analysis of gene expression in acetic acid-induced cerebral infarction model with SMTP-7 and t-PA treatment

Terumasa Hashimoto1, Keita Shibata1, Keiji Hasumi2, Kazuo Honda1
1Dept. Pharmacol., Showa Univ. Sch. Pharm., 2Dept. Appl. Biol. Sci., Tokyo Univ. of Agricul. and Technol.
Journal of Pharmacological Sciences 115 (suppl.1) 76-76, 2011.

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O1F2-J-1 TDP-43-induced neuronal death is mediated by the upregulation of Bim expression and the downregulation of Bcl-xL expression

Hiroaki Suzuki, Kikyo Lee, Masaaki Matsuoka
Dept. Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 76-76, 2011.

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O1F2-J-2 N-type calcium channel is involved in pathogenesis of experimental autoimmune encephalomyelitis

Naoki Tokuhara1, 2, Kana Namiki2, Mai Uesugi3, Chihiro Miyamoto4, Makoto Ohgoh1, Toshihiko Yamauchi1, Junro Kuromitsu4, Sadao Kimura2, Norimasa Miyamoto4, Yoshitoshi Kasuya2
1Neuroscience PCU, EPCS, Eisai Co.,Ltd., 2Dept Biochem. Mol. Pharmacol., Grad. Sch. Med., Chiba Univ., 3BPM CFU, EPCS, Eisai Co.,Ltd., 4KAN PCU, EPCS, Eisai Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 76-76, 2011.

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O1F2-J-3 Apocynin preserves retinal cone cell function in a mouse model for recessive retinitis pigmentosa caused by a mutation in the Pde6a gene

Takayuki Ishii1, Asami Mori1, Tsutomu Nakahara1, Kenji Sakamoto1, Juergen K. Naggert2, Patsy M. Nishina2, Kunio Ishii1
1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2The Jackson Laboratory
Journal of Pharmacological Sciences 115 (suppl.1) 77-77, 2011.

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O1F2-J-4 A study of glutathione synthesis induced by purine derivatives in the mouse brain

Koji Aoyama, Nobuko Matsumura, Masahiko Watabe, Fan Wang, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 77-77, 2011.

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O1F2-J-5 Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria

Yuka Kimura1, Yu-ichi Goto2, Hideo Kimura1
1Dept. Mol. Pharmacol. National Inst. Neuroscience, NCNP, 2Dept. Mol. Mental Retardation and Birth Defect Research. National Inst. Neuroscience, NCNP
Journal of Pharmacological Sciences 115 (suppl.1) 77-77, 2011.

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O1F3-J-1 The regulatory mechanism of intracellular localization of the GDP-dependent Rab27a effector coronin 3 in pancreatic beta-cells

Toshihide Kimura, Mami Yamaoka, Shigeki Taniguchi, Ichiro Niki
Dept. Pharmacol., Oita Univ. Fac. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 77-77, 2011.

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O1F3-J-2 Regulatory mechanisms of aggresome formation

Masahiko Watabe, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 78-78, 2011.

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O1F3-J-3 Functional analysis of novel growth suppressor Amida

Yasuyuki Irie1, Makio Saeki2, Koichi Kato3, Yukiko Kondo1, Shinpei Otake1, Kenzo Mizuma1, Hiroo Iwata3, Yoshinori Kamisaki2, Eiichi Taira1
1Dept. Pharmacol., Iwate Med. Univ., 2Dept. Pharmacol., Umin Univ. Grad. Sch. Den., 3Inst. Frontier Med. Sciences., Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 78-78, 2011.

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O1F3-J-4 Live-cell imaging analysis of cytoplasmic dynein-dynactin using multifunctional GFP tag

Takuya Kobayashi1, Yuta Watanabe2, Toshiyuki Kitai3, Takayuki Takahagi3, Yoko Y. Toyoshima2, Takashi Murayama1
1Dept. Pharmacol., Juntendo Univ. Sch. Med., 2Grad. Sch. Arts Sci., The Univ. Tokyo, 3Grad. Sch. Adv. Sci. Matt., Hiroshima Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 78-78, 2011.

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O1F3-J-5 Visualization of tissue-tissue interaction-triggered Ca2+ elevation for cell polarization during Xenopus gastrulation with improved GCaMP-type genetic Ca2+ probes

Masamichi Ohkura1, Asako Shindo2, Yusuke Hara2, Takamasa Yamamoto2, Naoto Ueno2, Junichi Nakai1
1Saitama Univ. Brain Sci. Inst., 2Dept. Dev. Biol., NIBB
Journal of Pharmacological Sciences 115 (suppl.1) 78-78, 2011.

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O1F3-J-6 Pharmacological studies on the respiratory tract (Rpt 347)： possible mechanism involved in enhanced responsiveness to NO in nasal mucosa of antigen-challenged rats

Tatsuya Hara, Yumiko Oiso, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Dept. Pharmacol., Hoshi Univ. Sch. Pharmacy
Journal of Pharmacological Sciences 115 (suppl.1) 79-79, 2011.

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O1F4-J-1 Functional differences between hippocampus and prefrontal cortex underlying context-dependent fear extinction in rats

Yasuhiro Saito1, Machiko Matsumoto1, Yoshiki Yanagawa1, Chika Judo1, Sachiko Hiraide1, Yasunori Kubo1, Shuhei Ishikawa1, Mitsuhiro Yoshioka2, Hiroko Togashi1
1Dept. Phamacol., Fac. of Pharm. Sci., Health Sci. Univ. of Hokkaido, 2Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 79-79, 2011.

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O1F4-J-2 Sigma-1 receptor stimulation by dehydroepiandeosterone (DHEA) ameliorates the cognitive deficits through activation of CaMKII, PKC and ERK in olfactory bulbectomized mice

Shigeki Moriguchi, Yui Yamamoto, Tatsuya Ikuno, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ., Grad. Sch. Pharmaceut. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 79-79, 2011.

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O1F4-J-3 Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats

Yu Ohmura, Iku Tsutsui-Kimura, Haruko Kumamoto, Takeshi Izumi, Taku Yamaguchi, Takayuki Yoshida, Mitsuhiro Yoshioka
Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 79-79, 2011.

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O1F4-J-4 Study on pain control system (Rept. 123)： sleep disturbance associated with the inhibition of endogenous GABAergic transmission under the neuropathic pain state induced by sciatic nerve ligation

Akira Yamashita, Satoshi Imai, Keiichi Niikura, Masaharu Furuya, Michiko Narita, Hiroshi Horiuchi, Naoko Kuzumaki, Tsutomu Suzuki, Minoru Narita
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 80-80, 2011.

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O1G1-J-1 Polyinosinic polycytidylic acid (poly (I：C)) accelerates the progression of emphysema induced by cigarette smoke (CS) or cigarette smoke extract (CSE) in mice

Hikaru Katoh, Hiroyuki Tanaka, Junichi Higuchi, Yuh Kajiwara, Yoji Nagira, Naoki Inagaki
Lab., Pharmacol., Dept., Bioactive Mol., Gifu Pharm. Univ
Journal of Pharmacological Sciences 115 (suppl.1) 80-80, 2011.

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O1G1-J-2 Comprehensive analyses for factors causing COPD

Kensuke Tanaka1, 2, Hirofumi Matsunaga3, Hiroyuki Amano1, 2, Takeshi Kobayashi1, 2, Junji Ishida4, Akiyoshi Fukamizu4, Masahiko Hagiwara3, Sadao Kimura1, Koichiro Tatsumi2, Yoshitoshi Kasuya1
1Dept. Biochem. and Mol. Pharmacol., Chiba Univ. Med., 2Dept. Respirol., Chiba Univ. Med., 3Ube Industries Ltd., 4Life Sci. center of TARA, Tsukuba Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 80-80, 2011.

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O1G1-J-3 Functional analysis of ion channels in murine airway ciliated cell

Eiji Sawada, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept. Mol & Cell, Pharmcol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 80-80, 2011.

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O1G1-J-4 Pharmacological studies on the respiratory tract (Rpt. 348)： involvement of soluble epoxide hydrolase in antigen-induced airway inflammation in mice

Aya Shibuya, Yuji Okamoto, Yoshihiko Chiba, Hiroyasu Sakai, Miwa Misawa
Dept. of Pharmacol., Sch. of Pharmacy., Hoshi Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 81-81, 2011.

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O1G1-J-5 Regulatory roles of interleukin (IL)-10 on neutrophil recruitment during the late asthmatic response (LAR) in mice

Ayumu Ikedo1, Toyoko Morishita1, Masanori Fujii1, Nobuaki Mizutani2, Shin Yoshino2, Casey T. Weaver3, David D. Chaplin4
1Dept. Pharmacol., Kyoto Pharm. Univ., 2Dept. Pharmacol., Kobe Pharm. Univ, 3Dept. Pathol., Univ. Alabama Birmingham, 4Dept. Microbiol., Univ. Alabama Birmingham
Journal of Pharmacological Sciences 115 (suppl.1) 81-81, 2011.

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O1G1-J-6 Lipidomics analysis revealed pro-resolving lipid mediators involved in the pathogenesis of influenza

Yumiko Imai1, Keiji Kuba1, Masayuki Morita1, Takashi Suzuki1, Masaki Saito1, Takayo Nakanishi1, Takao Shimizu2, Ryo Taguchi2, Yoshihiro Kawaoka3
1Dept. Biological Informatics and Experimental Therapeutics, Akita Univ. Faculty. Med, 2Dept. Biochemistry and Molecular Biology, Tokyo Univ. Faculty. Med, 3Dept. Microbiology and Immunology, Inst. of Med. Sci., Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 81-81, 2011.

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O1G2-J-1 Therapeutic implications of cGMP/PKG pathway in pathogenic activation of a mutant TRPC6 channel associated with familial focal segmental glomerulosclerosis (FSGS)

Jun Ichikawa, Ryuji Inoue
Dept. Physiol., Fukuoka Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 81-81, 2011.

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O1G2-J-2 Effect of nicorandil and cromakalim on ischemia-reperfusion injury in the rat kidney

Motoaki Saito, Shogo Shimizu, Fumiya Ohmasa, Panagiota Tsounapi, Yukako Kinoshita, Keisuke Satoh
Div. of Molecular Pharmacol., Tottori Univ. Sch. of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 82-82, 2011.

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O1G2-J-3 Sarpogrelate, a selective serotonin 5-HT2A receptor antagonist, improves ischemia/reperfusion-induced renal injury in mice

Yuki Shiimura1, 2, Junpei Mutoh1, 2, Keizo Sato3, 4, Hiroaki Hisa1, 2
1Second Dept. Pharmacol. Kyusyu Univ. of Health and Welfare Sch. Pharm., 2Second Dept. of Pharmacol., Sch. of Pharmaceutical Sciences, Kyusyu Univ. of Health and Welfare, 3First Dept. Biochem. Kyusyu Univ. of Health and Welfare Sch. Pharm., 4First Dept. of Biochemistry, Sch. of Pharmaceutical Sciences, Kyusyu Univ. of Health and Welfare
Journal of Pharmacological Sciences 115 (suppl.1) 82-82, 2011.

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O1G2-J-4 Establishment of procedure for comprehensive mass spectrometric analysis of epithelial cell membrane transporters

Shushi Nagamori, Kazuaki Takafuji, Yoshikatsu Kanai
Bio-system Pharmacol., Osaka Univ. Grad Sch Med
Journal of Pharmacological Sciences 115 (suppl.1) 82-82, 2011.

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O1G2-J-5 A novel cell system of autoclasis with single action potential for screening of drug development targeting on ion channels

Masato Fujii, Susumu Ohya, Hisao Yamamura, Yuji Imaizumi
Dept. Mol. & Cell. Pharmcol., Grad. Sch. Pharmceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 82-82, 2011.

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O1G2-J-6 Randomization for simultaneous balancing of several items and its performance evaluation

Chikuma Hamada, Masatake Oto
Tokyo Univ. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 83-83, 2011.

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O1G3-J-1 Involvement of granzyme A produced by CD4+ T cell and proteinase-activated receptor 2 in itch-associated responses to mosquito allergy in mice

Tsugunobu Andoh1, Tasuku Akiyama2, Akihisa Enokida1, Yasushi Kuraishi1
1Dept. Appl. Pharmacol., Grad. Sch. Med. Pharm., Univ. Toyama, 2Dept. Neurobiol., Physiol., Behav., Univ. California
Journal of Pharmacological Sciences 115 (suppl.1) 83-83, 2011.

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O1G3-J-2 Effects of barbiturates, benzodiazepines and a GABAA receptor selective agonist on scratching behavior in hairless mice with atopic dermatitis

Kaori Takeuchi, Masanori Fujii, Takeshi Nabe
Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 83-83, 2011.

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O1G3-J-3 Effects of histamine H4 receptor antagonist JNJ7777120 on the mouse model of atopic dermatitis

Eriko Suwa, Katsunori Yamaura, Koichi Ueno
Dept. Geriat. Pharmacol. Therapeut., Grad. Schl. Pharmaceut. Sci., Chiba Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 83-83, 2011.

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O1G3-J-4 Intranasal administration of Semaphorin 3A alleviates symptoms in murine model of allergic rhinitis

Haruna Sawaki1, 2, Fumio Nakamura1, Michiko Aihara2, Youji Nagashima3, Zenrou Ikezawa2, Yoshio Goshima1
1Dept. Mol. Pharmacol., Grad. Sch. Med. Yokohama City Univ., 2Dept. Dermatol., Grad. Sch. Med. Yokohama City Univ., 3Dept. Mol. Pathol., Grad. Sch. Med. Yokohama City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 84-84, 2011.

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O1G3-J-5 Development and analysis of food allergy model using mice

Hirotaka Yamashita, Keita Takahashi, Hiroyuki Tanaka, Hiroichi Nagai, Naoki Inagaki
Lab., Pharmacol., Dept., Bioactive Mol., Gifu Pharm. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 84-84, 2011.

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O1G3-J-6 fMLP and CINC-1 regulate chemotaxis of rat neutrophils through different signaling pathway

Yukio Azuma, Masnori Kashimata
Dept. Dental Pharmacol., Asahi Univ. Sch. Dent.
Journal of Pharmacological Sciences 115 (suppl.1) 84-84, 2011.

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O1G4-J-1 Biophysical analysis of NaV1.6-mediated resurgent Na+ currents in mouse vas deferens myocytes

Noriyoshi Teramoto1, Kazunari Hisadome1, Mari Yotsu-Yamashita2
1Dept. Pharmacol., Saga Univ. Sch. Med., 2Laboratory of Biophysical Chemistry, Grad. Sch. of Agricultural Sci., Tohoku Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 84-84, 2011.

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O1G4-J-2 Exchange protein directly activated by cAMP (Epac)-mediated cAMP signaling is involved in in vitro decidualization of human endometrial stromal cells

Kazuya Kusama, Mikihiro Yoshie, Kazuhiro Tamura, Yumina Kodaka, Masahiko Kutsukake, Eiichi Tachikawa
Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 85-85, 2011.

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O1G4-J-3 Effects of age and hypertension on α1-adrenoceptors in the major source arteries of the rat bladder and penis

Makoto Yono1, 2, Takanori Tanaka1, Shigeki Tsuji1, Shin Irie1, Yukikuni Sakata1, Masayuki Otani2, Jamshid Latifpour3
1Dept. Clin. Pharmacol., Nishi-Kumamoto Hosp., Med. Co. LTA, 2Dept. Urol., Nishi-Kumamoto Hosp., Med. Co. LTA, 3Sect. Urol., Yale Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 85-85, 2011.

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O1G4-J-4 Modulation of potassium channels via the α1B-adrenergic receptor in human osteoblasts

Daisuke Kodama, Akifumi Togari
Dept. of Pharmacol., Aichi-Gakuin Univ. Sch. Dent.
Journal of Pharmacological Sciences 115 (suppl.1) 85-85, 2011.

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O1G4-J-5 The stimulatory effects of NF-кB inhibitor on bone formation

Kazuhiro Aoki1, Masud Khan1, 2, Neil Alles1, Hiroyuki Nakachi3, Kenichi Nagano1, Yukihiko Tamura1, Teruo Amagasa3, Eijiro Jimi4, Keiichi Ohya1
1Dept. Hard Tissue Engineering (Pharmacol.), Grad. Sch., Tokyo Med. & Dent. Univ., 2GCOE program, Tokyo Med. & Dent. Univ., 3Dept. Maxillofacial Surg., Grad. Sch., Tokyo Med. & Dent. Univ., 4Dept. Molecular Biochemistry, Grad. Sch., Kyusyu Dental College
Journal of Pharmacological Sciences 115 (suppl.1) 85-85, 2011.

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O1G4-J-6 Ganglioside GM3 synthase knockout mice exhibit the hearing loss associated with degeneration of cochlear stereocilia

Misato Yoshikawa1, 2, Shinji Go2, Shizuo Komune3, Michihiro Fujiwara1, Katsunori Iwasaki1, Jin-ichi Inokuchi2
1Dept. of Neuropharmacol., Fac. of Pharm. Sci., Fukuoka Univ., 2Div. of Glycopatho., Inst. of Mol. Biomem. and Glycobio., Tohoku Pharm. Univ., 3Dept. of ORL., Grad. Sch. of Med., Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 86-86, 2011.

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O2D1-E-1 Origin of the cerebral microvascular pericytes in the neurogenesis period

Seiji Yamamoto1, Masashi Muramatsu2, Erika Azuma1, 3, Mitsuko Dohmoto3, Ken-ichi Takano1, Satomi Kita4, Takahiro Iwamoto4, Issei Komuro5, Shumpei Niida2, Masabumi Shibuya6, Naoyuki Matsuda7, Yuichi Hattori1
1Dept. of Molecular and Med. Pharmacol., Univ. of Toyama, 2Laboratory of Genomics and Proteomics, National Center for Geriatrics and Gerontology, Aichi, 3Kanazawa Inst. of Technology, Genome Biotechnology Laboratory, 4Dept. of Pharmacol., Fukuoka Univ., 5Dept. of Cardiovascular Med., Osaka Univ., Grad. Sch. of Med., 6Dept. of Molecular Oncology, Tokyo Med. and Dental Univ., 7Dept. Emergency and Critical Care Med., Nagoya Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 86-86, 2011.

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O2D1-E-2 The mechanism of ADP receptor P2Y12-mediated migration of bone-marrow-derived smooth muscle-like cells

Yuji Matsumoto, Kosuke Harada, Kazuo Umemura
Dep. Pharmacol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 86-86, 2011.

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O2D1-E-3 Angiotensin II-induced vascular remodeling is suppressed in smooth muscle cell-specific hypoxia-inducible factor-1α deficient mice

Masaki Imanishi1, Keisuke Ishizawa2, Yoshitaka Kihira1, Yasumasa Ikeda1, Koichiro Tsuchiya2, Toshiaki Tamaki1, Shuhei Tomita1
1Dept. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch., 2Dept. Med. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 86-86, 2011.

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O2D1-E-4 Stimulation of Prostaglandin D2 receptor DP promotes endothelial barrier function via Epac/Rac activation

Koji Kobayashi, Takahisa Murata, Masatoshi Hori, Hiroshi Ozaki
Dept. Vet. Pharmacol., Grad Sch. Agri. and Life Sci., The Univ. Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 87-87, 2011.

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O2D1-E-5 Caveola promotes BK-VDCC complex in vascular smooth muscle cells

Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept. Mol. & Cell. Pharmcol., Grad. Sch., Pharmceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 87-87, 2011.

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O2D1-E-6 A gap junction channel blocker reduces dilatation and inflammation of atrium： a possible role of ATP released from stretched atrial myocytes in macrophage migration in vivo

Sakiko Oishi1, Tetsuo Sasano2, Tetsushi Furukawa1
1Dept. Bioinformational Pharmacol., MRI, Tokyo Med. & Dent. Univ., 2MTT program, MRI, Tokyo Med. & Dent. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 87-87, 2011.

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O2D2-E-1 CCR4-NOT complex is a novel regulator of heart function conserved from Drosophila to humans

Keiji Kuba1, Takashi Suzuki1, Masayuki Morita1, Masaki Saito1, Akinori Kimura2, Gozoh Tsujimotgo3, Keiichi Fukuda4, Josef Penninger5, Yumiko Imai1
1Dept. Biol. Informatics & Exp. Therapeutics, Akita Univ. Grad. Sch. Med., 2Med. Res. Inst., Tokyo Med. Dent. Univ., 3Dept. Genome Drag delivery Sciences, Kyoto Univ. Grad. Sch. Pharm., 4Dept. Cardiology, Keio Univ. Sch. Med., 5IMBA
Journal of Pharmacological Sciences 115 (suppl.1) 87-87, 2011.

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O2D2-E-2 Autophagy is a candidate process of the endogenous cardioprotective function in Tsumura Suzuki Obese Diabetes mice

Shigeo Miyata1, Miyuki Yagi1, Mikio Nakazawa2, Tomie Kawada1
1Res. Inst. Pharmaceutical Sci., Musashino Univ., 2Dept. Med. Tech., Sch. Health Sci., Fac. Med., Niigata Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 88-88, 2011.

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O2D2-E-3 Th17 cells are indispensable for myocardial inflammation in autoimmune myocarditis

Tomomi Yamashita, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clim. Pharmacol. and Pharmacogenom., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 88-88, 2011.

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O2D2-E-4 Diverse pharmacological actions between fluvoxamine and paroxetine on cardiac hypertrophy and dysfunction

Hideaki Tagashira, Shenuarin Bhuiyan Md, Norifumi Shioda, Kohji Fukunaga
Tohoku Univ. Grad. Sch. of Pharm. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 88-88, 2011.

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O2D2-E-5 Role of brain 5-HT levels in the onset of heart failure in a mouse model of dilated cardiomyopathy

Lei Li, Sachio Morimoto, Dong-Yun Zhan, Yuan-Yuan Wang, Cheng-Kun Du, Xue-Li Fan, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 88-88, 2011.

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O2D3-E-1 Regulation of hydrogen sulfide production and its cytoprotective effect

Yoshinori Mikami1, Norihiro Shibuya1, Yuka Kimura1, Yuki Ogasawara2, Noriyuki Nagahara3, Hideo Kimura1
1Dept. Mol. Pharmacol., Natl. Neurosci., NCNP, 2Dept. Hyg. Chem., Meiji Pharm. Univ., 3Dept. Environ. Med., Nippon Med. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 89-89, 2011.

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O2D3-E-2 TNF receptor-1 functions as a Gq-coupled receptor mediating TNF-alpha signaling to stimulate glucose transport in adipocytes

Takeshi Imamura, Masashi Tawa, Ayman Geddawy, Takashi Shimosato, Tomio Okamura
Dept. Pharmacol., Shiga Univ. Med. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 89-89, 2011.

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O2D3-E-3 Dynein-driven transport of TCR microclusters forms Immune synapse and regulates T cell activation

Akiko Hashimoto-Tane, Tadashi Yokosuka, Machie Sakuma, Takashi Saito
RIKEN, Allergy and Immunology
Journal of Pharmacological Sciences 115 (suppl.1) 89-89, 2011.

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O2D3-E-4 PTP1B negatively regulates JAK/STAT cardioprotective signaling in cardiomyocytes

Shiho Murasawa1, Masanori Obana1, Tomohiko Iwakura1, Kazuki Matsui1, Momoko Shiragaki1, Kohei Katayama1, Kaori Miyamoto1, Junichi Azuma2, Hiroyuki Nakayama1, Yasushi Fujio1
1Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ. Pharma., 2Dept. Clin. Pharmacogenom. Hyogo Univ of Health Sci. Pharma.
Journal of Pharmacological Sciences 115 (suppl.1) 89-89, 2011.

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O2D3-E-5 Novel Activator of G-protein signaling 11 (AGS11)/TFE3 regulates transcription of claudin via activation of nuclear Galpha16

Motohiko Sato, Masahiro Hiraoka, Hiroko Suzuki, Yunzhe Bai, Satoshi Okumura, Yoshihiro Ishikawa
Cardiovascular Research Inst., Yokohama City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 90-90, 2011.

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O2D3-E-6 Gender difference in the expression of ABCB1 in PBMCs using standard curve and comparative Ct methods

Patcharaporn Sudchada, Oranun Kerdpin, Sarawut Oo-Puthinan, Nuttawut Saelim
Pharmacy Practice, Naresuan Univ., Faculty of Pharmaceutical Science, Naresuan Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 90-90, 2011.

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O2D4-E-1 A novel human urate/anion exchanger URAT2 identified as a novel target of uricosuric agents

Promsuk Jutabha1, Naohiko Anzai1, Kenichiro Kitamura2, Kimiyoshi Ichida3, Ichiro Hisatome4, Toru Kimura1, Seiji Ueno1, Yoshikatsu Kanai5, Hitoshi Endou1, Hiroyuki Sakurai1
1Dept. Pharmacol. Toxicol., Kyorin Univ. Sch. Med., 2Dept. Nephrol, Kumamoto Univ. Grad. Sch. of Med. and Pharmaceut. Sci., 3Dept. Pathophysiol, Tokyo Univ. of Pharm. and Life Sci., 4Dept. Genetic Med. Regen. Ther., Tottori Univ. Grad. Sch. of Med. Sci., 5Dept. Pharmacol, Osaka Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 90-90, 2011.

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O2D4-E-2 AQP1 translocation and degradation partially mediated the diuretic effect of acetazolamide

Xuejun Li, Jianzhao Zhang, Yu An
Dept. of Pharmacol., Sch. of Basic Med. Sciences, Peking Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 90-90, 2011.

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O2D4-E-3 Sleep disturbance associated with an enhanced orexinergic system induced by chronic treatment with paroxetine and milnacipran

Mahardian Rahmadi, Minoru Narita, Akira Yamashita, Satoshi Imai, Naoko Kuzumaki, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 91-91, 2011.

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O2D4-E-4 Standardized extract of Centella asiatica ECa 233 improved cognitive deficits induced by beta-amyloid peptide (25-35)

Mayuree H. Tantisira, Anchalee Kam-Eg, Boonyong Tantisira
Dept. of Pharmacol. and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 91-91, 2011.

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O2D4-E-5 Neuroprotective effect of Chinese Herbal Compound Sanqimingmu on rat retinal damage induced by N-methyl-D-aspartate

Min Liu, Jun-Xian Wang, Lan-Jie Pei, Mei-Mei Jia, Bei-Pan Chen, He-Bin Tang
Dept. Pharmacol., College of Pharmacy., South-Central Univ. for Nationalities
Journal of Pharmacological Sciences 115 (suppl.1) 91-91, 2011.

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O2D4-E-6 Involvement of RNA-binding protein HuR in c-Fos mRNA stabilization by emetin in human granulocytes

Xiaomin Feng, Yayoi Shikama, Junko Kimura
Dept. Pharmacol., Fukushima Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 91-91, 2011.

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O2E1-E-1 Protective effect of edaravone on diabetes-induced penile dysfunction

Fumiya Ohmasa, Motoaki Saito, Seiya Inoue, Panagiota Tsounapi, Syougo Shimizu, Yukako Kinoshita, Keisuke Satoh
Mol Pharmacol., Tottori Univ. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 92-92, 2011.

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O2E1-E-2 Endogenous H2S augments secretory functions via activation of Cav 3.2 T-type Ca2+ channels in neuroendocrine-differentiated prostate cancer cells

Kazuki Fukami1, Ryuji Kasamatsu1, Shigeru Yoshida2, Fumiko Sekiguchi1, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm., 2Dept. Life Sci., Kinki Univ. Sch. Sci. Engineer.
Journal of Pharmacological Sciences 115 (suppl.1) 92-92, 2011.

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O2E1-E-3 mTOR is involved in RANKL reverse signaling

Akiko Hanamura, Masashi Honma, Shigeki Aoki, Yoshiaki Kariya, Hiroshi Suzuki
Dept. Pharm., The Univ. Tokyo Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 92-92, 2011.

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O2E1-E-4 Neuromedin B stimulates proliferation of rat calvarial osteoblast acting through the NMB receptor

Hiroki Saito1, Kazuhiko Inoue1, Ryuji Ikeda2, Tomoya Nakamachi3, Seiji Shioda3, Sayaka Nagata4, Kazuo Kitamura4, Naoto Minamino5, Atsuro Miyata1
1Dept. Pharmacol., Ka Univ. Sch. Med., 2Dept. Pharma., Ka Univ. Hosp., 3Dept. Anato., Sho Univ. Med., 4Dept. Inter. Med., Miya Univ. Med., 5Dept. Pharmacol., Nat Car Insti.
Journal of Pharmacological Sciences 115 (suppl.1) 92-92, 2011.

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O2E1-E-5 Regulation by osteocyte-derived growth differentiation factor 15 of osteoclast activity

Eiichi Hinoi, Eri Nakatani, Takeshi Takarada, Yukio Yoneda
Dept. Mol. Pharmacol., Kanazawa Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 93-93, 2011.

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O2E1-E-6 Dynamic in vivo imaging of differentiation and function of osteoclasts in live bones by using intravital two-photon microscopy

Junichi Kikuta1, Issei Nishiyama1, Atsuko Kubo1, Yutaka Shimazu1, Yoh Wada2, Masaru Ishii1
1Lab. Biological Imaging, IFReC, Osaka Univ., 2ISIR, Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 93-93, 2011.

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O2E2-E-1 PACAP is implicated in regulation of neurite and dendritic spine formation

Katsuya Ogata1, Atsuko Hayata1, 2, Kaoru Seiriki1, Keisuke Hazama1, Hisae Momosaki1, Norihito Shintani1, Akemichi Baba3, Hitoshi Hashimoto1, 2, 4
1Lab. Mol. Neruopharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Center Child Mental Dev., Unit. Grad. Sch. Child Dev., Osaka Univ., 3Pharmaceut. Sci., Hyogo Univ. of Health Sci, 4Dep. Mol. Pharmaceut. Sci., Grad. Sch. Med., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 93-93, 2011.

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O2E2-E-2 Paroxetine prevents the decrease in L-glutamate transporter activity caused by lipopolysaccharide

Junpei Takaki1, 2, Kaoru Sato2, Takeshi Suzuki1
1Div. Basic Biol Sci., Fac. Pharm., Keio Univ., 2Div. Pharmacol., Natl. Inst. Hlth. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 93-93, 2011.

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O2E2-E-3 Antidepressants induce the expression of fibroblast growth factor-2 in rat primary cultured astrocyte

Naoto Kajitani1, Kazue Hisaoka1, 2, Norimitu Morioka1, Masahiro Kaneko1, Ryoya Yano1, 2, Mami Tsuchioka2, Minoru Takebayashi2, 3, Yoshihiro Nakata1
1Dept. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Sci., 2Inst. Clin Res., Natl. Hosp. Org. Kure Med. Ctr., 3Dept. Psychiatry., Natl. Hosp. Org. Kure Med. Ctr.
Journal of Pharmacological Sciences 115 (suppl.1) 94-94, 2011.

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O2E2-E-4 Enhancement of microglial Aβ phagocytosis via allosteric regulation of nicotinic acetylcholine receptor

Kazuyuki Takata1, Yoshihisa Kitamura1, Shun Shimohama2, Takashi Taniguchi1
1Dept. Neurobiol., Kyoto Pharm. Univ., 2Dept. Neurol., Sapporo. Med. Univ., Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 94-94, 2011.

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O2E2-E-5 Regulatory mechanisms controlling expression of tyrosine hydroxylase by V-1/CapZ complex, a novel regulator of actin dynamics

Ichiro Kawahata, Jyunichi Morita, Tohru Yamakuni
Grad. Sch. of Pharm. Sci., Tohoku Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 94-94, 2011.

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O2E2-E-6 Reversible gene expression control of serotonin receptor 1a in orexin neurons enables to regulate sleep/wakefulness pattern

Sawako Tabuchi1, 2, Tomomi Tsunematsu1, 2, Shyouta Sugio1, 2, Kenji Tanaka1, 2, Makoto Tominaga1, 2, Akihiro Yamanaka1, 2
1NIPS, 2SOKENDAI, Dept. Physiological Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 94-94, 2011.

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O2E3-E-1 Inverse agonist-like action of cadmium on inward rectifier K+ channels

Atsushi Inanobe1, Atsushi Nakagawa2, Yoshihisa Kurachi1
1Dept. Pharmacol., Osaka Univ. Grad. Sch. of Med., 2Inst. for Protein Res., Osaka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 95-95, 2011.

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O2E3-E-2 Post-translational palmitoylation and regulation of ionotropic glutamate receptors in neurons

Takashi Hayashi
Dept. Mol. Neurobiol. and Pharmacol., Grad. Sch. Med. Univ. Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 95-95, 2011.

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O2E3-E-3 Reelin regulates the formation of dentate granule cell layer

Mayuko Miura1, Junya Ichikawa1, Atsushi Baba2, Mitsuharu Hattori2, Norio Matsuki1, Ryuta Koyama1
1Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Univ. Tokyo, 2Dept. Biomed. Sci., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 95-95, 2011.

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O2E3-E-4 Fear memory coding in neuronal subpopulations within the amygdala, hippocampus and striatum

Hiroshi Nomura, Ayako Nonaka, Natsuko Imamura, Koichi Hashikawa, Norio Matsuki
Lab Chem Pharmacol, Grad Sch Pharm Sci, Univ of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 95-95, 2011.

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O2E3-E-5 Contactin associated protein 4 promotes neurogenesis through LNX2/Notch pathway

Yasuo Takeda1, Toshitaka Futagawa1, Zhi-Cheng Xiao2, Katsushi Yamada1
1Dept. Clinical Pharm. and Pharmacol., Kagoshima Univ. Grad. Sch. Med. and Dent. Sci., 2Monash Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 96-96, 2011.

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O2E3-E-6 Interleukin-6 family cytokines induce endothelial cell differentiation of cardiac Sca-1+ cells via STAT3/Pim-1 signaling pathway

Tomohiko Iwakura1, Tomomi Mohri1, Tatsuto Hamatani1, Tomomi Yamashita1, Masanori Obana1, Akiko Hayama1, Kazuki Matsui1, Makiko Maeda2, Junichi Azuma2, Hiroyuki Nakayama1, Yasushi Fujio1
1Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ. Pharma., 2Dept. Clin. Pharmacogenom. Hyogo Univ of Health Sci. Pharma.
Journal of Pharmacological Sciences 115 (suppl.1) 96-96, 2011.

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O2E4-J-1 Effects of Angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells

Toshiaki Ishizuka, Ayako Ozawa, Hazuki Goshima, Yasuhiro Watanabe
Dept. Pharmacol. Natl. Def. Med. Col.
Journal of Pharmacological Sciences 115 (suppl.1) 96-96, 2011.

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O2E4-J-2 Mechanism of human urotensin II-induced contraction of the isolated rat aorta

Katsunari Tasaki1, Ichiro Wakabayashi2
1Dept. Life Studies., Gifu Shotoku Gakuen Univ. Junior Coll., 2Dept. Environmental and Preventive Med., Hyogo College of Med.
Journal of Pharmacological Sciences 115 (suppl.1) 96-96, 2011.

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O2E4-J-3 Disruption of sphingosine-1-phosphate receptor-2 gene inhibits atherosclerosis in apoE-deficient mice

Fei Wang1, Yasuo Okamoto1, Isao Inoki2, Kazuaki Yoshioka1, Noriko Takuwa1, 3, Yoh Takuwa1
1Dept. Physiol., Kanazawa Univ. Sch. Med., 2Dept. Internal Med., Kanazawa Univ. Sch. Med., 3Dept. Health & Med. Sci., Ishikawa Pref. Nursing Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 97-97, 2011.

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O2E4-J-4 Role of advanced glycation end products with endothelin-1 induced vasocontraction in thoracic aorta from type 2 diabetic OLETF rats

Shingo Nemoto, Tsuneo Kobayashi, Kumiko Taguchi, Takayuki Matsumoto, Katsuo Kamata
Dept. Physiol. and Morphol., Inst Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 97-97, 2011.

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O2E4-J-5 Beta2-adrenergic receptor-mediated activation of Gi/o proteins causes a decrease in the t-tubular L-type Ca2+ channel current density in failing ventricular myocytes

Toshihide Kashihara1, Tsutomu Nakada1, Xiaona Sheng2, Toshihide Shibasaki1, Masamichi Hirose3, Mitsuhiko Yamada1
1Dept. Mol. Pharmacol., Shinshu Univ. Sch. Med., 2Dept. Metabolic Regulation, Shinshu Univ. Grad. Sch. Med., 3Dept. Mol. Cell. Pharmacol. Iwate Med. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 97-97, 2011.

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O2E4-J-6 Pharmacological analysis of the calcium channel subtypes involved in pacemaker depolarization of the sinus node

Iyuki Namekata1, Yayoi Tsuneoka1, Toru Ogawa1, Chisa Komikado1, Akira Takahara1, Hiroko Izumi-Nakaseko2, Satomi Adachi-Akahane2, Hikaru Tanaka1
1Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci., 2Dept. Pharmacol., Toho Univ. Fclt. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 97-97, 2011.

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O2F1-J-1 Frequency dependent Cdc42 activation in neurons revealed by novel fluorescent indicators based on forster resonance energy transfer

Yusaku Ohta, Syunsuke Kishi, Shigeyuki Namiki, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 98-98, 2011.

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O2F1-J-2 Visualization of MAPK activity in sensory neurons of living C.elegans

Taichiro Tomida, Haruo Saito
Div. of Mol. Cell Signaling. Inst. of Med. Sci., Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 98-98, 2011.

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O2F1-J-3 Evidence for pharmacologically distinct phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex

Atsushi Nishimune, Abu Syed Md Anisuzzaman, Hatsumi Yoshiki, Junsuke Uwada, Ikunobu Muramatsu
Div., Pharmacol., Med. Sch. Univ. Fukui
Journal of Pharmacological Sciences 115 (suppl.1) 98-98, 2011.

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O2F1-J-4 S(+)-ketamine suppresses desensitization of GABAB receptor-mediated signaling by inhibition of the interaction of GABAB receptors with G protein-coupled receptor kinase 4 and 5

Yasuhito Uezono1, 3, Yuko Ando2, Minoru Hojo2, Masafumi Takada2, Yuka Sudo1, 3, Koji Sumikawa2
1Div. Cancer Pathophysiol. NCCRI, 2Dept. Anest, Nagasaki Univ. Grad. Sch. Med. Sci., 3Dept. Mol. Cell. Biol., Nagasaki Univ. Grad. Sch. Med. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 98-98, 2011.

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O2F1-J-5 Implication of N-methyl-D-aspartate for upregulation of ryanodine receptor function in methamphetamine-induced rewarding effect

Kazuhiro Kurokawa, Masahiro Shibasaki, Koji Mizuno, Seitaro Ohkuma
Dept. Pharmacol., Kawasaki Med. Univ
Journal of Pharmacological Sciences 115 (suppl.1) 99-99, 2011.

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O2F1-J-6 Early postnatal stress affects extracellular signal-regulated kinase activation in corticolimbic regions during contextual fear extinction in adult rats

Shuhei Ishikawa1, Yoshiki Yanagawa1, Machiko Matsumoto1, Chika Judo1, Shin-ichi Kimura2, Kei-ichi Shimamura2, Hiroko Togashi1
1Dept. Pharmacol., Fac. of Pharm. Sci., Health Sci. Univ. of Hokkaido, 2Dept. of Clin. Pharmacol., Fac. of Pharm. Sci., Health Sci. Univ. of Hokkaido
Journal of Pharmacological Sciences 115 (suppl.1) 99-99, 2011.

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O2F2-J-1 Function of helix 8 of the human adrenomedullin 1 (AM1) receptor

Kenji Kuwasako1, Kazuo Kitamura2, Sayaka Nagata2, Tomomi Hikosaka2, Johji Kato1
1Frontier Sci. Res. Center, Univ. of Miyazaki, 2Div. of Circul. and Body Fluid Reg., Faculty of Med., Univ. of Miyazaki
Journal of Pharmacological Sciences 115 (suppl.1) 99-99, 2011.

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O2F2-J-2 Can glinide stimulate calcium mobilization from endoplasmic reticulum via ryanodine receptor?

Hideto Oyamada1, Toshiko Yamazawa2, Takashi Murayama3, Nagomi Kurebayashi3, Yusuke Ubukata1, Osamu Sato3, Hiroshi Takeshima4, Masamitsu Iino2, Takashi Sakurai3, Katsuji Oguchi1
1Dept. Pharamacol., Showa Univ. Sch. Med., 2Dept. Pharmacol., The Univ. Tokyo, Grad. Sch. Med., 3Dept. Pharamacol., Juntendo Univ. Sch. Med., 4Dept. Biol. Chem., Kyoto Univ. Grad. Sch. Pharamaceut. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 99-99, 2011.

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O2F2-J-3 The possible role of the endoplasmic reticulum as an intracellular source of ATP in the release

Takeshi Katsuragi
Med. Res. Cent. Sch. Med. Fukuoka Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 100-100, 2011.

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O2F2-J-4 Protein kinase Cα associates with an alteration of carbachol-induced bladder contraction in adiponectin-transgenic mice

Koji Nobe1, Akiko Fujii1, Takaharu Negoro2, Yasuko Nakano2, Kazuo Honda1
1Dept. Pharmacol., Showa Univ. Sch. Pharm., 2Dept. Pharmacogen., Showa Univ. Sch. Pharm.
Journal of Pharmacological Sciences 115 (suppl.1) 100-100, 2011.

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O2F2-J-5 Expression and function of ryanodine receptor type 3 in nonpregnant and pregnant myometrium of the mice

Masashi Takemoto1, Hisao Yamamura1, Susumu Ohya1, Hiroshi Takeshima2, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmcol., Grad. Sch. Pharmceut. Sci. Nagoya City Univ., 2Dept. Biol. Chem., Grad. Sch. Pharmceut. Sci, Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 100-100, 2011.

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O2F2-J-6 Pharmacological studies on the respiratory tract (Rept. 344)： role of JNK in the augmented bronchial smooth muscle contraction of antigen-induced airway hyperresponsive rats

Yu Watanabe, Yuki Nagai, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Dept. Pharmacol., Sch. of Pharmacy, Hoshi Univ
Journal of Pharmacological Sciences 115 (suppl.1) 100-100, 2011.

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O2F3-J-1 Possible involvement of β-endorphin in docosahexaenoic acid induced antinociception

Kazuo Nakamoto1, Takashi Nishinaka1, Akihiro Ambo2, Mitsumasa Mankura3, Shogo Tokuyama1
1Dept. Clinic. Pharm., Fac. Pharmaceu. Sci., Kobe Gakuin Univ., 2Dept. Biochem, Tohoku Pharmaceutical Univ., 3Ikeda Tohka Industries Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 101-101, 2011.

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O2F3-J-2 Ambroxol reverses hyperalgesia on mice model of diabetic neuropathy

Kenichiro Tanaka1, 2, Kimiko Maeda1, Risako Kato1, Masahiro Ohsawa1, Megumi Asato1, Hiroko Ikeda1, Junzo Kamei1
1Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Dept. Endoclinol. Metab., Yokohama City Univ., Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 101-101, 2011.

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O2F3-J-3 Epigenetic therapy targeting histone deacetylase in chronic pain

Hitoshi Uchida, Kohei Araki, Hiroshi Ueda
Div. Mol. Pharmacol & Neurosci., Nagasaki Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 101-101, 2011.

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O2F3-J-4 Pharmacological assessments of supraspinal nitric oxide synthase (NOS) isoforms and NO downstream signaling in the maintenance of neuropathic pain

Ken Okamoto1, Hideki Ono1, Mitsuo Tanabe1, 2
1Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Lab. Pharmacol., Sch. Pharm. Sci., Kitasato Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 101-101, 2011.

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O2F3-J-5 Implication of bradykinin receptor in pain related to acute pancreatitis

Yoshinori Takemura1, 2, Sadayoshi Furuta1, Shigeto Hirayama1, Kazuhiko Miyashita1, Satoshi Imai1, Michiko Narita1, Naoko Kuzumaki1, Mitsuaki Yamazaki2, Tsutomu Suzuki1, Minoru Narita1
1Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Dept. Anesthesiology, Grad. Sch. Med. Pharmaceut. Sci. Res. Univ. Toyama.
Journal of Pharmacological Sciences 115 (suppl.1) 102-102, 2011.

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O2F4-J-1 iNOS regulation by the SPRY domain- and SOCS box-containing proteins

Tadashi Nishiya1, Kazuma Matsumoto1, Satoshi Maekawa1, Takahiro Horinouchi1, Masahiro Fujimuro2, Kouetsu Ogasawara3, Takashi Uehara4, Soichi Miwa1
1Dept. Cellular Pharmacol., Hokkaido Univ. Grad. Sch. Med., 2Dept. Mol. Cell. Biol., Grad. Sch. Med. & Eng., Univ. of Yamanashi, 3Dept. Immunol., IDAC, Tohoku Univ., 4Dept. Med. Pharmacol., Grad. Sch. Med. Dent. & Pharm., Okayama Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 102-102, 2011.

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O2F4-J-2 Disodium cromoglicate inhibits gene expression of inflammation-related cytokines in lungs of septic mice

Ken-ichi Takano, Kengo Tomita, Hiroki Yokoo, Yuichi Hattori
Dept. of Mol. Med. Pharmacol., Grad. Sch. Med. Pharm. Sci., Univ. of Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 102-102, 2011.

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O2F4-J-3 Discovery and validation of a predictive parameter on sedative properties of antihistamine drugs： the QSAR analysis on the mechanism underlying the adverse effect

Yoshihiro Uesawa1, Shigeru Hishinuma2, Masaru Shoji2, Kiminori Mohri1
1Dept. of Clinical Pharmaceutics, Meiji Pharm. Univ., 2Dept. of Pharmacodynamics, Meiji Pharm. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 102-102, 2011.

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O2F4-J-4 Silencing of AQP5 gene expression decreases keratinocyte chemoattractant expression in lung epithelial cells

Yuima Sakamoto, Akinori Hisatsune, Hiroshi Katsuki, Yoichiro Isohama
Dept. Chemico-Pharm. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 103-103, 2011.

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O2F4-J-5 Toll-like receptor (TLR) 9 is involved in the onset of Dermatophagoides farinae (Der f)-induced asthma in mice

Yuji Masuta, Hiroyuki Tanaka, Yuya Ezaki, Takeshi Murata, Naoki Inagaki, Hiroichi Nagai
Lab., Pharmacol., Dept., Bioactive Mol., Gifu Pharm. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 103-103, 2011.

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O2F4-J-6 Signaling pathways of protein phosphorylation under the development of pulmonary fibrosis

Takeshi Kobayashi1, 2, Kensuke Tanaka1, 2, Hiroyuki Amano1, 2, Hirofumi Matsunaga3, Masahiko Hagiwara3, Sadao Kimura1, Koichiro Tatsumi2, Yoshitoshi Kasuya1
1Dept. Biochemistry and Molecular Pharmacol., Chiba Univ. Sch. Med, 2Dept. Respirol., Chiba Univ. Sch. Med, 3Ube Industries, Ltd
Journal of Pharmacological Sciences 115 (suppl.1) 103-103, 2011.

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O2G1-J-1 Hepatocyte growth factor suppresses the antineoplastic effect of CPT-11 by increasing the expression of CES2 and UGT1A1 in HepG2 cells

Manabu Okumura, Tomomi Iwakiri, Akinori Takagi, Masashi Nagata, Yasutoshi Hirabara, Yohei Kawano, Kazuhiko Arimori
Dept. Pharmacy, Miyazaki Univ. Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 103-103, 2011.

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O2G1-J-2 The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cells

Yukihiko Nishizawa1, Ryuji Ikeda2, Shigeto Matsushita3, Xiao-Fang Che4, Tatsuhiko Furukawa4, Sho Tabata1, Mina Ushiyama2, Yusuke Tajitu1, 2, Masatatsu Yamamoto4, Kentaro Minami1, Hironori Mataki1, Tatsuya Yamaguchi2, Yasuo Takeda1, 2, Shin-ichi Akiyama5, Katsushi Yamada1, 2
1Dept. Clin. Pharm. and Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ., 2Dept. Clin. Pharm., Kagoshima Univ. Hosp., 3Dept. Dermatol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ., 4Dept. Mol. Oncology, Grad. Sch. Med. Dent. Sci., Kagoshima Univ., 5Dept. Int. Med. Mol. Ther., Grad. Sch., Tokushima Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 104-104, 2011.

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O2G1-J-3 Demethylating agent enhances chemosensitivity to vinblastine in renal cell carcinoma

Hiroki Iwata1, Hiromi Sato1, Rina Suzuki1, Ryota Yamada1, Saki Ichinomiya1, Midori Yanagihara1, Hiroyuki Okabe1, Tomohiro Yano2, Koichi Ueno1
1Dept. Geriatr. Pharmacol. Therapeut., Grad. Sch. of Pharmaceut. Sci., Chiba Univ., 2Grad. Sch. of Life Sci., Toyo Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 104-104, 2011.

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O2G1-J-4 Elucidation of the mechanisms underlying the anti-metastatic action of nicotine and tar-free cigarette smoke extract

Yuta Takahashi1, Yoko Kimoto1, Arisa Nishiuchi1, Ayuko Sato1, Mami Kakuda1, Noriko Yoshikawa1, Satomi Kagota2, Kazumasa Shinozuka2, Masaru Kunitomo1, Kazuki Nakamura1
1Dept. Pharmacol. I, Mukogawa Women's Univ. Sch. Pharm., 2Dept. Pharmacol. II, Mukogawa Women's Univ. Sch. Pharm.
Journal of Pharmacological Sciences 115 (suppl.1) 104-104, 2011.

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O2G1-J-5 The correlations between sensitivity to mitomycin C and NQO1 activity in pancreatic cancer cells

Saori Yoshida1, Katsushige Mizuno2
1Grad. Sch. Sci. and Eng., Ritsumeikan Univ., 2Coll. Life Sci., Ritsumeikan Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 104-104, 2011.

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O2G1-J-6 Effect of opioid receptor agonists in gefitinib-resistant non-small cell lung cancer

Atsuo Suzuki1, Naoko Kuzumaki1, Takahiro Hosoya2, Michiko Narita1, Kozue Tsukiji1, Masami Suzuki3, Yasuhito Uezono3, Hiroshi Morita2, Tsutomu Suzuki1, Minoru Narita1
1Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Faculty of Pharmaceutical Sciences, Hoshi Univ., 3Cancer Pathophysiol. Div., Nat. Cancer cent.
Journal of Pharmacological Sciences 115 (suppl.1) 105-105, 2011.

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O2G2-J-1 Procyanindin is a naturally-occurring LOX-1 antagonist and inhibits lipid accumulation in vascular wall

Ryo Yoshimoto1, Taichi Nishiduka2, Yoshiko Fujita1, Yuko Sato1, Atsushi Nakano1, Akemi Kakino1, Shunji Oshima2, Tomomasa Kanda2, Tatsuya Sawamura1
1Dept. Vasc Physiol, Ntnl Cerebr Cardiovasc Cent, 2Fundamental Research Laboratory, Asahi Breweries Limited, Fund Res Lab, Asahi Breweries
Journal of Pharmacological Sciences 115 (suppl.1) 105-105, 2011.

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O2G2-J-2 Vasculoprotective action of fluvoxamine through sigma-1 receptor stimulation in pressure overload-induced vascular injury

Kohji Fukunaga, Hideaki Tagashira, Bhuiyan Md Shenuarin
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Scis.
Journal of Pharmacological Sciences 115 (suppl.1) 105-105, 2011.

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O2G2-J-3 Nitorosonifedipine, a photodegradative metabolite of nifedipine, improves angiotensin II-induced vascular remodeling

Takumi Sakurada1, Keisuke Ishizawa2, Masaki Imanishi1, Erika Tominaga3, Junpei Taniguchi3, Shoko Fujii2, Yoshitaka Kihira1, Yasumasa Ikeda1, Shuhei Tomita1, Koichiro Tsuchiya2, Toshiaki Tamaki1
1Dept. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch., 2Dept. Med. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch., 3Dept. Clin. Pharmacy, Inst. HBS, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 105-105, 2011.

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O2G2-J-4 Protective effect of serofendic acid on myocardial ischemia-reperfusion injury in rat

Tadaaki Ioroi1, Masaharu Akao2, Toshiaki Kume1, Moritake Iguchi2, Yasuhiko Izumi1, Akinori Akaike1
1Dept. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ., 2Dept. Cardiovasc. Med., Grad. Sch. Med., Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 106-106, 2011.

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O2G2-J-5 Effects of combining YM150, an oral direct factor Xa inhibitor, with antiplatelet agents in rats

Yoshiyuki Iwatsuki1, Chinatsu Sakata2, Yumiko Moritani2, Seiji Kaku1, Masao Sasamata1, Nobuo Seki1
1Applied Pharmacol. Res. Labs., Drug Discovery Res, Astellas Pharma Inc., 2Pharmacol. Res. Labs., Drug Discovery Res, Astellas Pharma Inc.
Journal of Pharmacological Sciences 115 (suppl.1) 106-106, 2011.

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O2G2-J-6 Effects of administration of statins for a certain term before undergoing coronary artery bypass grafting on inflammatory responses

Kazuo Nakamura1, Harunobu Iwase1, Kenichi Sako1, Hiroko Kariyazono2, Kazuo Takahama3, Ryuzo Sakata4
1Dept. Biopharmaceu., Nihon Pharmaceu. Univ., 2Facu. Pharmaceu. Sci., Nagasaki Int. Univ., 3Dept. Environ. Anal. Sci., Grad. Sch. Med., Kumamoto Univ., 4Dept. Card. Surg. Grad. Sch. Med. Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 106-106, 2011.

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O2G3-J-1 Deferoxamine, an iron chelator, promotes revascularization via endothelial cells activation

Yasumasa Ikeda1, Soichiro Tajima1, Sumiko Yoshida2, Noriko Yamano1, Yoshitaka Kihira1, Keisuke Ishizawa1, Ken-ichi Aihara2, Shuhei Tomita1, Koichiro Tsuchiya3, Toshiaki Tamaki1
1Dept. Pharmacol., The Univ of Tokushima Grad. Sch. Med, 2Dept. Med. and Bio. Sciences., The Univ of Tokushima Grad. Sch. Med., 3Dept. Med. Pharmacol., The Univ of Tokushima Grad. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 106-106, 2011.

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O2G3-J-2 Inward rectifier K+(Kir2.1) channel as a factor regulating cell death in bovine brain endothelial cells

Hiroaki Kito1, Daiju Yamazaki1, 2, Hisao Yamamura1, Susumu Ohya1, Kiyofumi Asai2, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci, Nagoya City Univ., 2Dept. Mol. Neurobiol., Grad. Sch. Med. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 107-107, 2011.

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O2G3-J-3 Insulin-induced NO-independent vasodilation in the human endothelium-denuded saphenous vein

Tasuku Kanai1, Yasuko Matuo1, Naoko Tanaka1, Masachika Kuwabara2, Eisaku Nakamura4, Hiroaki Hisa3, Ryuichi Yamamoto1
1First Dept. Pharmacol., Kyuho Univ. Sch. Pharm, 2Kuwabara Clinic, 3Second Dept. Pharmacol., Kyuho Univ. Sch. Pharm, 4Dept. Cardiovasc surgery, Miyazaki Pref, Nobeoka Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 107-107, 2011.

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O2G3-J-4 Mechanisms underlying impairment of endothelium-dependent relaxation in organ-cultured rat mesenteric artery with FBS

Tomoka Morita, Hideyuki Yamawaki, Muneyoshi Okada, Yukio Hara
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 107-107, 2011.

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O2G3-J-5 Losartan normalizes P2Y receptor-mediated contraction by suppression of cPLA2/COX pathway in mesenteric arteries from rats in later-stage type 2 diabetes

Keiko Ishida, Takayuki Matsumoto, Kumiko Taguchi, Tsuneo Kobayashi, Katsuo Kamata
Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 107-107, 2011.

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O2G4-J-1 Angiotensin II induces podocyte apoptosis through the activation of Na+/H+ exchanger-1 and oxidative stress

Ya Liu, Hirofumi Hitomi, Suwarni Diah, Daisuke Nakano, Akira Nishiyama
Dept. Pharmacol., Kagawa Univ. Med. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 108-108, 2011.

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O2G4-J-2 Imidapril increases insulin-like growth factor-I production via stimulation of the sensory neuron in spontaneously hypertensive rats

Naoaki Harada, Kenji Okajima
Dept. Translational Med. Sci. Res., Nagoya City Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 108-108, 2011.

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O2G4-J-3 Up-regulation of neuropeptide Y receptors in hypotensive mouse vasomotor center

Shin-ichi Murase, Hiroshi Higuchi
Div. of Pharmacol., Molecular and Cellular Med., Niigata Univ., Grad. Sch. of Med. and Dental Sciences
Journal of Pharmacological Sciences 115 (suppl.1) 108-108, 2011.

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O2G4-J-4 Olmesartan attenuates angiotensin II induced interleukin-23 production in cardiac fibroblast

Kohei Katayama, Akiko Hayama, Tomomi Yamasita, Shiho Murasawa, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ. Pharma.
Journal of Pharmacological Sciences 115 (suppl.1) 108-108, 2011.

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O2G4-J-5 Assessment of cardiac function using quantitative gene knockdown and fluorescent cardiac image analysis in zebrafish

Noriko Umemoto1, Yuhei Nishimura1, 2, 3, 4, Seiya Kishi1, Yukiko Yamanaka1, Saki Itou1, Kana Okamori1, Yasuhito Shimada1, 2, 3, 4, Junya Kuroyanagi1, Zi Zhang1, Toshio Tanaka1, 2, 3, 4
1Pharmacogenomics, Mie Univ. Grad. Sch. of Med., 2Med. Zebrafish Research Center, Mie Univ., 3Bioinfomatics, Mie Univ. Life Sci. Research Center, 4Med. Chemogenomics, Mie Univ. Venture Business Laboratory
Journal of Pharmacological Sciences 115 (suppl.1) 109-109, 2011.

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O2G4-J-6 Olmesartan inhibits atrial remodeling in a mouse model of chronic heart failure

Masamichi Hirose1, Yasuchika Takeishi2, Hisashi Shimojo3, Toshihide Kashihara4, Tsutomu Nakada4, Koichi Nakayama1, Mitsuhiko Yamada4
1Dept. Molecular and Celluar Pharmacol., Iwate Med. Univ. Sch. Pham., 2Dept. Cardiol., Fukushima Med. Univ. Sch. Med., 3Dept. Patho., Shinshu Univ. Sch. Med., 4Dept. Molecular Pharm., Shinshu Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 109-109, 2011.

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O3D1-E-1 Control of cancer cell growth and chemoresistance by silencing of the Nrf2-antioxidant system： implication of ErbB2 repression

Mi-Kyoung Kwak, Sarala Manandhar, In-Geun Ryu
College of Pharmacy, Yeungnam Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 109-109, 2011.

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O3D1-E-2 PGE2 enhances wound-induced intestinal myofibroblast migration via EP2, EP3 and EP4 receptors

Koichi Iwanaga, Muneyoshi Okada, Takahisa Murata, Masatoshi Hori, Hiroshi Ozaki
Dept. Vet. Pharmacol., Grad Sch. Agri and Life Sci., The Univ. Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 109-109, 2011.

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O3D1-E-3 Cathelicidin antimicrobial peptide (CAMP) is induced in autoimmune myocarditis and reduces the motility of cardiac fibroblasts

Kazuki Matsui1, Tomomi Yamashita1, Haruyo Kawaguchi1, Tomohiko Iwakura1, Masanori Obana1, Akiko Hayama1, Shiho Murasawa1, Kohei Katayama1, Momoko Shiragaki1, Makiko Maeda2, Junichi Azuma1, Hiroyuki Nakayama1, Yasushi Fujio1
1Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ. Pharma., 2Dept. Clin. Pharmacogenom. Hyogo Univ of Health Sci. Pharma.
Journal of Pharmacological Sciences 115 (suppl.1) 110-110, 2011.

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O3D1-E-4 Interleukin-11 exhibits the post-conditioning effects against ischemia reperfusion injury through cardiac STAT3 activation

Masanori Obana1, Kaori Miyamoto1, Tomohiko Iwakura1, Akiko Hayama1, Tomomi Yamashita1, Shiho Murasawa1, Momoko Shiragaki1, Makiko Maeda2, Junichi Azuma2, Hiroyuki Nakayama1, Yasushi Fujio1
1Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ. Pharma., 2Dept. Clin. Pharmacogenom. Hyogo Univ of Health Sci. Pharma.
Journal of Pharmacological Sciences 115 (suppl.1) 110-110, 2011.

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O3D1-E-5 Effect of mitochondrial dysfunction in the lipid deposited blood vessels of hyperglycemia induced spontaneously hypertensive hyperlipidemic rats

Toshio Kumai1, Minoru Watanabe2, Yuko Takeba2, Naoki Matsumoto2, Junki Koike3, Shinichi Kobayasi2
1Dept. Pharmacogenomics, St. Marianna Univ. Sch. Med. Grad. Sch., 2Dept. Pharmacol., St. Marianna Univ. Sch. Med, 3Dept. Pathology, St. Marianna Univ. Sch. Med
Journal of Pharmacological Sciences 115 (suppl.1) 110-110, 2011.

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O3D1-E-6 Noninvasive method for detecting sign of congestive heart failure in DCM model mice

Masami Sugihara1, 2, Takeshi Suzuki1, 2, Fuminori Odagiri1, 2, Yuji Nakazato3, Hiroyuki Daida2, Takashi Sakurai1, Sachio Morimoto4, Nagomi Kurebayashi1
1Dept. Pharmacol., Juntendo Univ. Sch., 2Dept. Cardiol., Juntendo Univ. Sch. Med., 3Dept. Cardiol., Juntendo Urayasu Hosp., 43)Dept. Clinical Pharmacol, Fac Med Sci., Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 110-110, 2011.

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O3D2-E-1 In vivo calcium imaging of C. elegans body wall muscles with genetically encoded calcium probe G-CaMP

Junichi Nakai1, Keiko Gengyo-Ando1, Atsushi Usami2, Masamichi Ohkura1, Yuji Ikegaya2, Norio Matsuki2
1Saitama Univ. BSI, 2Lab. Chem. Pharmacol. Grad. Sch. Pharm. Sci. Tokyo Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 111-111, 2011.

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O3D2-E-2 Detection of cardiac troponin T in detrusor smooth muscle -does troponin system operate in smooth muscle?-

Shunichi Kajioka1, Fumi Takahashi2, Nouval Sha1, Mitsuho Onimaru3, Narihito Seki1, Shinsuke Nakayama4, Masato Hirata5, Seiji Naito1
1Dept. Urol., Kyushu Univ. Sch. Med., 2Dept. Clipharm., Kyushu Univ. Sch. Med., 3Dept. Pathol., Kyushu Univ., Sch. Med., 4Dept. Cell Physiol., Nagoya Univ., Sch. Med., 5Labo. Mol. Cell. Biol., Kyushu Univ., Sch. Dent.
Journal of Pharmacological Sciences 115 (suppl.1) 111-111, 2011.

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O3D2-E-3 Disruption of leptin signal exacerbates myocardial injury by enhancing ER stress after myocardial infarction

Momoko Shiragaki, Masanori Obana, Shiho Murasawa, Kaori Miyamoto, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ
Journal of Pharmacological Sciences 115 (suppl.1) 111-111, 2011.

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O3D2-E-4 VKORC1 analysis is useful for long-term maintenance aid, not for determining the maintenance dose of warfarin therapy

Naoki Matsumoto1, Minoru Watanabe1, Yuko Takeba1, Yoshie Harimoto1, Sachiko Takenoshita1, Eiji Takahashi2, Masahiro Yamauchi2, Shonosuke Ryu3, Yukako Ishikawa3, Toshio Kumai4, Masami Tanaka5, Fumihiko Miyake3, Haruki Musha2, Shinichi Kobayashi1
1Dept. Pharmacol., St. Marianna Univ. Sch. Med., 2Div. Cardiolo., St. Marianna Univ., Yokohama-city, Seibu Hosp., 3Div. Cardiol., St. Marianna Univ. Sch. Med., 4Dept. Pharmacogenomics, St. Marianna Univ. Sch. Med., 5Dept. Experimental Animals, St. Marianna Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 111-111, 2011.

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O3D2-E-5 Comparing the distribution of ABCB1 SNPs (2677G>T/A and 3435C>T) among Thai and other populations

Patcharaporn Sudchada, Oranun Kerdpin, Sarawut Oo-Puthinan, Nuttawut Saelim
Pharmacy Practice, Naresuan Univ., Faculty of Pharmaceutical Sci., Naresuan Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 112-112, 2011.

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O3D3-J-1 Negative regulation of endothelin type A receptor-operated TRPC6 by adenylate cyclase/cAMP/PKA pathway

Takahiro Horinouchi, Tsunaki Higa, Tadashi Nishiya, Hiroyuki Aoyagi, Hiroyuki Suzuki, Arata Nishimoto, Soichi Miwa
Dept. Cell Pharmacol., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 112-112, 2011.

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O3D3-J-2 Expression of TMEM16 family as molecular counterparts of Ca2+ activated Cl- channel in vascular smooth muscle cells

Junya Ohshiro, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci. Nagoya City Univ
Journal of Pharmacological Sciences 115 (suppl.1) 112-112, 2011.

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O3D3-J-3 The junctional membrane-targeting motif in C-terminal of L-type calcium channel α1c subunits

Tsutomu Nakada1, 2, 3, Flucher Bernhard2, Xiaona Sheng1, Toshihide Kashihara1, Toshihide Shibazaki1, Masamichi Hirose3, Mitsuhiko Yamada1
1Dept. Mol. Pharmacol., Shinshu Univ. Sch. Med., 2Dept. Pysiol. Med. Phys., Innsbruck Med. Univ., 3Dept. Mol. Cel. Pharmacol., Sch. Pharm. Sci., Iwate Med. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 112-112, 2011.

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O3D3-J-4 L-type Ca2+ channel, Cav1.3 in SAN is responsible for the diastolic depolarization of pacemaker potential

Hiroko Izumi-Nakaseko, Masanori Ito, Hiroko Maruyama, Atsushi Sugiyama, Satomi Adachi-Akahane
Dept. Pharmacol., Sch. Med., Fac. Med., Toho Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 113-113, 2011.

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O3D3-J-5 Electrical remodeling and lethal arrhythmia in DCM model mice

Takeshi Suzuki1, 2, Takao Shioya3, Takashi Murayama1, Masami Sugihara1, 2, Fuminori Odagiri1, 2, Yuji Nakazato2, Hiroyuki Daida2, Takashi Sakurai1, Sachio Morimoto4, Nagomi Kurebayashi1
1Dept. Pharmacol, Juntendo Univ. Sch. Med., 2Dept. Cardiol, Juntendo Univ. Sch. Med., 3Dept. Physiol. Fac. Med. Saga Univ., 4Dept. Clin Pharmacol., Fac Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 113-113, 2011.

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O3E1-J-1 Direct visualization of ATP-evoked dynamics in single P2X4 receptor

Youichi Shinozaki1, 2, Koji Sumitomo1, Makoto Tsuda3, Schuichi Koizumi2, Kazuhide Inoue3, Keiichi Torimitsu1
1NTT BRLs, 2Dept of Pharmacol, Univ. of Yamanashi, 3Dept. Mol. Sys. Pharmacol. Kyushu Univ., Collabo station II 408, Kyushu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 113-113, 2011.

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O3E1-J-2 Roles of Rho family GTPases during cerebellar development

Masakazu Hayashibe1, Takehiko Ueyama1, Takeshi Kondoh2, Jeonghyun Son1, Mizuho Sakahara3, Hidetoshi Kassai3, Kazuki Nakao3, Atsu Aiba3, Naoaki Saito1
1Lab. of Mol. Pharmacol., Biosignal. Res. Ctr., Kobe Univ., 2Dept. of Neurosurgery, Kobe Univ. Grad. Sch. of Med., 3Center for Disease Biology and Integrative Med., Faculty of Med., Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 113-113, 2011.

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O3E1-J-3 Regulation of glutamate transport by runt related factor-2 in astrocytes

Takeshi Takarada, Kouichi Fujikawa, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 114-114, 2011.

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O3E1-J-4 1-deoxy-nor-sominone (Denosomin) promotes the neurite outgrowth via astrocyte-mediated signaling in the spinal cord

Kiyoshi Teshigawara1, Aiko Nagata1, Tomoharu Kuboyama1, Yuji Matsuya2, Chihiro Tohda1
1Div. of Biofunctional Evaluation, Res. Center for Ethnomed., Inst. of Natural Med., Univ. of Toyama, 2Lab. of Organochem. Design and Synthesis, Fac. of Pharmaceutical Sci., Univ. of Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 114-114, 2011.

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O3E1-J-5 Fluorocitrate； an inhibitor of astrocytic metabolism attenuates the preference induced by 2-week intake of high-fat diets

Mai Katsuki1, Sei Higuchi1, Ryuji Yamaguchi1, Maiko Araki1, Makiko Ohji1, Riyo Furuta1, Keiichi Irie1, Kiyoshi Matsuyama2, Kenji Mishima2, Kenichi Mishima1, Katsunori Iwasaki1, Michihiro Fujiwara1
1Dept. Neuropharmacology, Fukuoka Univ. Sch. Pharm. Sci., 2Dept. Chemical Engineering, Fukuoka Univ. Sch. Engineering.
Journal of Pharmacological Sciences 115 (suppl.1) 114-114, 2011.

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O3E1-J-6 Mechanisms underlying astrocyte-induced neuronal protection against methylmercury

Yusuke Noguchi, Keisuke Shibata, Kayoko Fujishita, Tetsuro Ozawa, Schuichi Koizumi
Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Pharmaceut. Sci. Med. and Engineering
Journal of Pharmacological Sciences 115 (suppl.1) 114-114, 2011.

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O3E2-J-1 Analysis of the protective effect of a retinoic acid receptor agonist Am80 on dopaminergic neurons in vivo

Hiroshi Katsuki1, Maiko Akiyama1, Sachiko Takemori1, Akinori Hisatsune1, Yoichiro Isohama1, Koichi Shudo2
1Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ., 2Itsuu Lab.
Journal of Pharmacological Sciences 115 (suppl.1) 115-115, 2011.

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O3E2-J-2 Involvement of the microglia in Parkinson's disease animal model by intranigral LPS injection

Atsuko Ishii1, Sachiko Tanaka1, Hirokazu Ohtaki2, Seiji Shioda2, Satoshi Numazawa1, Takemi Yoshida1
1Dept. Biochem. Toxicol., Showa Univ. Sch. Pharm., 2Dept. Anat., Sch. Med., Showa Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 115-115, 2011.

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O3E2-J-3 Therapeutic effect of zonisamide on MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine)-treated mice model of Parkinson's disease

Hironori Yokoyama1, Ryohei Yano1, Hiroyuki Kato2, Tsutomu Araki1, Jiro Kasahara1
1Dept. Neurobiol. Therapeu., Inst. Health Biosci. & Grad. Sch. Pharmaceu. Sci., Univ. Tokushima, 2Dept. Neurol., Ctr. Clin. Med., Int. Univ. Health and Welfare Hosp, Tochigi
Journal of Pharmacological Sciences 115 (suppl.1) 115-115, 2011.

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O3E2-J-4 Possible involvement of reactive oxygen species-induced ubiquitin ligase HRD1 insolubilization in amyloid β generation

Ryo Saito1, Masayuki Kaneko1, Yasuyuki Nomura2, Yasunobu Okuma1
1Dept. Pharmacol., Chiba Inst. of Sci., 2Lab. of Pharmacotherapeutics, Yokohama Col. of Pharm.
Journal of Pharmacological Sciences 115 (suppl.1) 115-115, 2011.

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O3E3-J-1 Detection of dopamine release from single dopaminergic neuronal soma in the midbrain of rats

Toshihiko Momiyama
Dept. Pharmacol., Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 116-116, 2011.

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O3E3-J-2 GluRδ2-Cbln1-NRXN tripartite complex regulates synapse formation in the cerebellum

Takeshi Uemura1, Sung-Jin Lee1, Misato Yasumura1, Tomonori Takeuchi1, Tomoyuki Yoshida1, Moonjin Ra2, Ryo Taguchi2, Kenji Sakimura3, Masayoshi Mishina1
1Dept. of Mol. Neurobiol. & Pharmacol., Grad. Sch. of Med., Univ. of Tokyo, 2Dept. of Metabolome, Grad. Sch. of Med., Univ. of Tokyo, 3Dept. Cell Neurobiol., Brain Res. Inst., Niigata, Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 116-116, 2011.

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O3E3-J-3 Adenosine A1 receptor regulates mGluR1 signaling and cerebellar LTD

Yuji Kamikubo1, Toshihide Tabata2, Takashi Sakurai1
1Dept. Phamacol., Juntendo Univ. Sch. Med., 2Lab. for Neural Info. Tech., Grad. Sch. of Sci. and Eng, Univ. of Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 116-116, 2011.

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O3E3-J-4 Regulation of hippocampal neural stem cell proliferation and differentiation by adenosine via equilibrative nucleoside transporter 1

Takahiro Moriya1, Yuko Suzuki1, Aya Hariu1, Takashi Katura1, Sun Choi2, Doo-Sup Choi2, Norimichi Nakahata1
1Dept. Cell. Signal., Grad. Sch. Pharm. Sci., Tohoku Univ, 2Mol. Pharm., Mayo Cli. Coll. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 116-116, 2011.

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O3E3-J-5 GABAB receptors do not internalize upon activation by baclofen because of lack of their association with β arrestin； comparison with μ opioid receptor-mediated signaling

Yuka Sudo1, 2, Minoru Hojo3, Yuko Ando3, Noriyuki Nishida1, Yasuhito Uezono1, 2
1Dept. Mol. Cell. Biol., Nagasaki Univ. Grad. Sch. Med. Sci., 2Dept. Cancer Pathophysiol., NCCRI, 3Dept. Anesthesiology, Nagasaki Univ. Grad Sch. Med. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 117-117, 2011.

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O3E3-J-6 Actin dynamics in ethanol-induced physical dependence

Masahiro Shibasaki, Koji Mizuno, Kazuhiro Kurokawa, Seitaro Ohkuma
Dept. Pharmacol., Kawasaki Med. Sch.
Journal of Pharmacological Sciences 115 (suppl.1) 117-117, 2011.

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O3F1-J-1 Emergence of ectopic mossy fiber terminals after experimental febrile seizures

Junya Ichikawa, Norio Matsuki, Ryuta Koyama
Lab. Chem. Pharmacol, Grad Sch Pharm, Univ Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 117-117, 2011.

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O3F1-J-2 Diacylglycerol kinase β (DGKβ) knockout mice are hyporesponsive to psychostimulant-induced behavioral changes

Mitsue Ishisaka, Atsushi Oyagi, Kenichi Kakefuda, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 117-117, 2011.

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O3F1-J-3 Loss of deacetylation activity of Hdac6 causes antidepressant-like behavior in mice

Masahide Fukada1, Atsuko Hanai1, Atsuo Nakayama1, Takayoshi Suzuki2, Naoki Miyata2, Yoshiharu Kawaguchi1
1Dept. Embryo., Dev. Res., Aichi Human Service Center, 2Dept. Organic and Medicinal Chemistry, Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 118-118, 2011.

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O3F1-J-4 Essence of chicken has an anti-stress effect through enhancing the histaminergic neuron system

Eiko Sakurai1, Hiroshi Kurihara3, Kazuhiko Yanai2
1Facul. Pharmacy, Iwaki Meisei Univ., 2Dep. of Pharmacol, Tohoku Grad. Univ. Sch. of Med., 3Ins. of Trad. Chinese Med. and Nat. Products, Jinan Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 118-118, 2011.

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O3F1-J-5 Influence of dopamine systems on the effect of GBR12909 in the runway method using intracranial self-stimulation behavior

Satoru Ezumi1, Yoichi Kawasaki1, Hidenori Sagara2, Hisashi Matsunaga1, Yutaka Gomita3, Toshiaki Sendo1
1Dept. Pharm., Okayama Univ. Hosp., 2Dept. Pharmaceut. Inf. Sci., Matsuyama Univ., 3Dept. Pharmacol., Shujitsu Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 118-118, 2011.

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O3F2-J-1 Effect of curcumin on extracellular and intracellular dopamine in PC12 cells： implication of plasmalemmal and vesicular monoamine transporters

Takaaki Matsuo1, Yasuhiko Izumi1, Toshiaki Kume1, Shuji Kaneko2, Hideyuki Sawada3, Hachiro Sugimoto4, Akinori Akaike1
1Dept. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ., 2Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ., 3Clin. Res. Cent., Utano Nat. Hosp., 4Wor.-Lead. Drug Discov. Res. Cent., Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 118-118, 2011.

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O3F2-J-2 The expression and function of a novel splicing variant, short form of sigma-1 receptor in mouse brain

Norifumi Shioda, Kiyoshi Ishikawa, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 119-119, 2011.

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O3F2-J-3 Functional analysis of carnitine/organic cation transporter OCTN1 (SLC22A4) expressed in mouse brain

Noritaka Nakamichi, Takayuki Taguchi, Hiroshi Hosotani, Hiroya Yamada, Tomoko Sugiura, Yukio Kato
Div. Pharm. Sci., Kanazawa Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 119-119, 2011.

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O3F2-J-4 Neuromodulatory effects of feeding peptides in GLP-1 releasing neurons of mouse brainstem

Kazunari Hisadome, Noriyoshi Teramoto
Dept. Pharmacol., Saga Univ
Journal of Pharmacological Sciences 115 (suppl.1) 119-119, 2011.

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O3F2-J-5 Dual action of hypothalamic orexin on hepatic glucose production through the brain-liver neural network in mice

Hiroshi Tsuneki, Emi Tokai, Yuya Nakamura, Mikio Fujita, Tsutomu Wada, Toshiyasu Sasaoka
Dept. Clin. Pharmacol., Univ. of Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 119-119, 2011.

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O3F3-J-1 Inhibition mechanism of Na, K-ATPase activity in rat brain by propofol

Yuri Hase1, Yoshiaki Deyama2, Yoshitaka Yoshimura2, Kazuaki Fukushima1, Kuniaki Suzuki2
1Div. Dent. Anesthesiol., Dept. Oral Pathobiol. Sci., Hokkaido Univ. Grad. Sch. Dent. Med., 2Div. Mol. Cell Pharmacol., Dept. Oral Pathobiol. Sci., Hokkaido Univ. Grad. Sch. Dent. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 120-120, 2011.

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O3F3-J-2 Toxicogenomic analysis of mebendazole-induced retinopathy on inner plexiform layer

Tetsuo Kon1, Yuhei Nishimura1, 2, 3, 4, Noriko Umemoto1, Zi Zhang1, Junya Kuroyanagi1, Yasuhito Shimada1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Pharmacogenomics, Mie Univ. Grad. Sch. of Med., 2Med. Zebrafish Research Center, Mie Univ, 3Med. Chemogenomics, Mie Univ. Venture Business Laboratory, 4Bioinformatics, Mie Univ. Life Sci. Research Center
Journal of Pharmacological Sciences 115 (suppl.1) 120-120, 2011.

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O3F3-J-3 Analysis of cisplatin-induced acute and delayed pica in rats using automatic feeding monitoring system

Kouichi Yamamoto1, Naoki Matsukawa1, Yuko Ogura1, Masahiro Imaizumi2, Atsushi Yamatodani1
1Dept. Med. Sci. Tech., Div. Health Sci, Grad. Sch. Med. Osaka Univ., 2Melquest Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 120-120, 2011.

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O3F3-J-4 Comparison of statistical analysis and descriptions between Journal of Pharmacological Science and European Journal of Pharmacology

Chikuma Hamada, Takahiro Arafune
Tokyo Univ. Sci.
Journal of Pharmacological Sciences 115 (suppl.1) 120-120, 2011.

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O3G1-J-1 The anti-tumor effect of Cordyceps sinensis on human HT1080 fibrosarcoma cells via a reduction of c－MYC expression

Mami Kakuda1, Noriko Yoshikawa1, Yuta Takahashi1, Yoko Kimoto1, Ayuko Sato1, Arisa Nishiuchi1, Masaru Kunitomo1, Satomi Kagota2, Kazumasa Sinozuka2, Kazuki Nakamura1
1Dept. Pharmacol. I, Mukogawa Women's Univ. Sch. Pharm., 2Dept. Pharmacol. II, Mukogawa Women's Univ. Sch. Pharm.
Journal of Pharmacological Sciences 115 (suppl.1) 121-121, 2011.

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O3G1-J-2 Effects of the specific fatty acid complex of Flammulina Velutipes (Curt.： Fr) Sing extract on the visceral fat syndrome

Daisuke Chino1, Shizuo Yamada2, Yoshihiko Ito2, Shoichi Kurihara3, Yoshihiro Waki1, Yasuo Watanabe1
1Dept. Pharmacol., Nihon Pharmc Univ., 2Dept. of Pharmacokin and Pharmacodyn, Sch of Pharm Sci, Univ of Shizuoka, 3Ricom, Corp.
Journal of Pharmacological Sciences 115 (suppl.1) 121-121, 2011.

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O3G1-J-3 Preventive effect of a Kampo medicine, Daikenchuto (DKT) in rat postoperative intestinal adhesion： a possible involvement of TRPV1

Yohei Tokita, Masahiro Yamamoto, Kazuko Satoh, Mitsue Nishiyama, Seiichi Iizuka, Sachiko Imamura, Yoshio Kase
Tsumura Research Laboratories
Journal of Pharmacological Sciences 115 (suppl.1) 121-121, 2011.

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O3G1-J-4 Involvement of dynamin1, a synaptic endocytosis modulator, on the ameliorative effect of Yokukansan on memory disturbances in an animal model of Alzheimer's disease

Yuri Sakata1, Katunori Iwasaki1, Kotarou Takasaki1, Ai Nogami1, Sayaka Tashiro1, Miyuki Tanaka1, Naoki Uchida2, Tarou Shindou2, Kaori Kubota1, Syutarou Katurabayashi1, Kenichi Mishima1, Ryouji Nishimura2, Michihiro Fujiwara1
1Dept. Neurophamacol., Fukuoka Univ. Sch. Pharm. Sch, 2Dept. Psychiatry., Sch. Med
Journal of Pharmacological Sciences 115 (suppl.1) 121-121, 2011.

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O3G1-J-5 Behavioral pharmacological study on anti-stress effect of young green barley leaf extract in mice

Noriyuki Nakayama1, Katsunori Yamaura1, Maki Shimada1, Hideki Fukata2, Sadanori Abe2, Koichi Ueno1
1Dept. Geriatr. Pharmacol. Therapeut., Grad. Sch. Pharmaceut. Sci., Chiba Univ., 2JPD Co.,Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 122-122, 2011.

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O3G2-J-1 Subtype specificity of Ca2+/calmodulin-dependent protein kinase I α and γ

Kanzo Suzuki, Sayaka Takemoto-Kimura, Satoshi Kamijo, Masatoshi inoue, Hajime Fujli, Natsumi Ageta-Ishihara, Hiroyuki Okuno, Haruhiko Bito
Dept. of Neurochem., Grad. Sch. of Med., Univ. of Tokyo
Journal of Pharmacological Sciences 115 (suppl.1) 122-122, 2011.

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O3G2-J-2 Role of p38 in the pathogenesis of experimental autoimmune encephalomyelitis

Kana Namiki1, Hirofumi Matsunaga2, Jyunnji Ishida3, Naoki Tokuhara4, Mai Uesugi4, Tatsuhiko Sudo5, Masahiko Hagiwara2, Akiyoshi Fukamizu3, Sadao Kimura1, Yoshitoshi Kasuya1
1Dept. of Biochem. and Mol. Phaemacol., Grad. Sch. of Med., Chiba Univ., 2Ube Industries, Ltd, 3Life Sci. Center of TARA, Tsukuba Univ, 4Neuroscience PCU, EPCS, Eisai Co.,Ltd, 5Dept of Antibiotics, RIKEN
Journal of Pharmacological Sciences 115 (suppl.1) 122-122, 2011.

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O3G2-J-3 Regulation of insulin receptor expression by Hsp90 and co-chaperones

Toshihiko Yanagita1, Takayuki Nemoto1, Akihiko Wada2, Manabu Murakami1
1Dept. Pharmacol., Miyazaki Univ, 2Dept. Sports and Health and Welfare, Social Welfare, Kyushu Univ, Hlth. Welfare
Journal of Pharmacological Sciences 115 (suppl.1) 122-122, 2011.

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O3G2-J-4 VNUT plays an important role in vesicular storage and subsequent exocytosis of ATP from bladder epithelium upon mechanical stretch stimulation

Hiroshi Nakagomi1, Tsutomu Mochizuki1, Kayoko Fujishita2, Keisuke Shibata2, Tatsuya Miyamoto1, Yoshinori Moriyama3, Masayuki Takeda1, Schuichi Koizumi2
1Dept. Urology., Interdisciplinary Grad. Sch., Med. and Engineering, Univ. Yamanashi, 2Dept. Neuropharmacol., Interdisciplinary Grad. Sch., Med. and Engineering, Univ. Yamanashi, 3Dept. Membrane Biochemistry., Grad. Sch., Med., Dentistry, and Pharmaceutical Sciences, Okayama Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 123-123, 2011.

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O3G2-J-5 Upregulation of Runx2 expression in microglia exposed to ATP

Ryota Nakazato, Takeshi Takarada, Yukio Yoneda
Laboratory of Molecular Pharmacol., Kanazawa Univ. Grad. Sch. of Natural Sci. and Technology
Journal of Pharmacological Sciences 115 (suppl.1) 123-123, 2011.

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O3G2-J-6 Pharmacological studies on the respiratory tract (Rpt. 346)： augmented Ca2+ -dependent signaling in the aqueous cigarette tar-induced bronchial smooth muscle hyperresponsiveness in rats

Ayako Watanabe, Toshiaki Mitsui, Hiroyasu Sakai, Yoshihiko Chiba, Miwa Misawa
Dept. of Pharmacol., Sch. of Pharmacy, Hoshi Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 123-123, 2011.

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O3G3-J-1 Molecular mechanisms underlying the modulation of Kv1.3 channel activity by phosphatidylinositol 4, 5-bisphosphate

Takahiro Muramoto, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci, Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 123-123, 2011.

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O3G3-J-2 The P2Y13 receptor mediates murine macrophage chemotaxis toward extracellular ADP

Isao Matsuoka, Masa-aki Ito
Lab. Pharmacol, Facul. Pharm. Takasaki Univ. Health and Welfare
Journal of Pharmacological Sciences 115 (suppl.1) 124-124, 2011.

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O3G3-J-3 Ku86 represses PMA-induced up-regulation of histamine H1 receptor gene expression in HeLa cells

Hiroyuki Mizuguchi1, Takuma Terao1, Noriko Sakamoto1, Yoshiyuki Yoshimura2, Yousuke Yamawaki1, Katsumi Fujimoto3, Hiroyuki Fukui1
1Dept. Mol. Pharmacol., Inst. of Health-Biosciences, The Univ. Tokushima Grad. Sch., 2Dept. of Med. Pharmacol, Inst of Health Biosciences, The Univ. Tokushima Grad. Sch., 3Dept. of Biochem., Grad. Sch. Biomed. Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 124-124, 2011.

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O3G3-J-4 C2-Diethyl-ceramide-1-phosphate as a specific inhibitor of alpha-type cytosolic phospholipase A2

Tomohiko Makiyama1, Hiroyuki Nakamura1, Atsushi Nishida2, Toshihiko Murayama1
1Laboratory of Chemical Pharmacol., Grad. Sch. of Pharmaceutical Sciences, Chiba Univ., 2Laboratory of Organic Chemistry, Grad. Sch. of Pharmaceutical Sciences, Chiba Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 124-124, 2011.

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O3G3-J-5 Pharmacological studies on the respiratory tract (Rept. 345)： SOCS1 is a negative regulator of IL-13-induced upregulation of RhoA in cultured human bronchial smooth muscle cells

Masahiro Hayafune, Nanako Kobayashi, Yoshihiko Chiba, Hiroyasu Sakai, Miwa Misawa
Dept. Pharmacol., Sch. of Pharmacy., Hoshi Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 124-124, 2011.

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O3G3-J-6 Immune regulation via α2 adrenoceptor-mediated P13K activation in dendritic cells

Yoshiki Yanagawa, Machiko Matsumoto, Hiroko Togashi
Dept. Pharmacol., Health Sciences Univ. of Hokkaido
Journal of Pharmacological Sciences 115 (suppl.1) 125-125, 2011.

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O3H1-J-1 Physiological role of the dominant-negative Kca3.1 channel isoform in mice thymocytes

Susumu Ohya, Yuka Fukuyo, Hisao Yamamura, Yuji Imaizumi
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 125-125, 2011.

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O3H1-J-2 Stable cells to detect extracellular epitopes of N-methyl-D-aspartate receptor

Shiho Takano1, Yukitoshi Takahashi2, Hiroyuki Kishi3, Atushi Muraguchi3, Hisashi Mori1
1Dept. Mol. Neurosci., Grad. Sch. Med. & Pharma. Sci., Univ. Toyama, 2Dept. Pediatrics. Nat. Epilepsy Center., 3Dept. Immunology, Grad. Sch. Med. & Pharma. Sci., Univ. Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 125-125, 2011.

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O3H1-J-3 Changes in diagnostic sepsis biomarkers in plasma in mice with cecal ligation and puncture-induced sepsis

Kengo Tomita, Ken-ichi Takano, Michinori Takashina, Hiroki Yokoo, Yuichi Hattori
Dept. of Mol. Med. Pharmacol., Grad. Sch. Med. Pharm. Sci., Univ. of Toyama
Journal of Pharmacological Sciences 115 (suppl.1) 125-125, 2011.

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O3H1-J-4 Inhibitory effect of trypsin on LPS-signaling in peritoneal macrophages

Hiroyuki Komatsu, Akihiro Shimose, Takashi Ohama, Koichi Sato
Lab. Vet. Pharmacol, Univ. Yamaguchi
Journal of Pharmacological Sciences 115 (suppl.1) 126-126, 2011.

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O3H1-J-5 Deficiency of starch was one of causes in a diet-induced atopic dermatitis-like dry skin of hairless mice

Yuki Shimazaki, Masanori Fujli, Takeshi Nabe
Dept. Pharmacol., Kyoto Phram. Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 126-126, 2011.

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O3H1-J-6 Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema

Shinya Kashiwagi1, 2, Kanako Hosono1, Tatsunori Suzuki1, Masataka Majima1
1Dept. Pharmacol., Kitasato Univ Sch. Med., 2Dept. Plastic and Aesthetic Surgery Kitasato Univ Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 126-126, 2011.

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O3H2-J-1 Ketamine induces apoptosis, resulting in the growth inhibition of C6, rat neural malignant tumor cells

Hidetomo Niwa1, 2, Ken-Ichi Furukawa2, Kazuhiko Seya2, Shigeru Motomura2, Kazuyoshi Hirota1
1Dept. Anesthesiol., Hirosaki Univ. Grad. Sch. Med., 2Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 126-126, 2011.

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O3H2-J-2 Involvement of noradrenergic and serotonergic systems in the analgesic effect of neurotropin on the oxaliplatin-induced neuropathic pain

Hitomi Watanabe1, Takehiro Kawashiri1, Nobuaki Egashira1, 2, Ken Masuguchi1, Yoko Tashushima1, Takahisa Yano2, Hiroaki Ikesue2, Ryozo Oishi2
1Grad. Sch. Pharm. Sci., Kyushu Univ., 2Dept. Pharm., Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 115 (suppl.1) 127-127, 2011.

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O3H2-J-3 Anti-tumor activity of naphthoquinone monooxime

Ryota Yamada1, Hiromi Sato1, Hiroki Iwata1, Midori Yanagihara1, Saki Ichinomiya1, Rina Suzuki1, Hiroyuki Okabe1, Tomohiro Yano2, Takuya Kumamoto3, Tsutomu Ishikawa1, Koichi Ueno1
1Dept. Geriatr. Pharmacol. Therapeut., Grad. Sch. of Pharmaceut. Sci. Chiba Univ., 2Grad. Sch. of Life Sci., Toyo Univ., 3Res. Inst. of Pharmaceut. Sci., Musashino Univ.
Journal of Pharmacological Sciences 115 (suppl.1) 127-127, 2011.

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O3H2-J-4 Evaluation of the patterns of brain metastases using BBB Kit

Kunihiko Tanaka1, Yutaka Tagawa2, 3, Masami Niwa1, 3
1Dept. Pharmacol., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2Dept. Nur., Nagasaki Univ. Grad. Sch. Biomed. Sci., 3PharmaCo-Cell Co.Ltd.
Journal of Pharmacological Sciences 115 (suppl.1) 127-127, 2011.

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O3H2-J-5 A proteomics strategy to elucidate stress-damaged proteins

Masayuki Shiota1, Masako Tanaka1, Saya Mun1, Takafumi Nakao1, Yasukatsu Izumi1, Katsuyuki Miura2, Hiroshi Iwao1
1Dept. Pharmacol., Osaka City Univ., Grad. Sch. Med., 2Appl. Pharmacol. Ther., Osaka City Univ., Grad. Sch. Med.
Journal of Pharmacological Sciences 115 (suppl.1) 127-127, 2011.

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