Journal of Pharmacological Sciences 121巻 suppl号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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PL1 AUTONOMIC NEUROTRANSMISSION: 60 YEARS SINCE SIR HENRY DALE

Geoffrey Burnstock
University College Medical School
Journal of Pharmacological Sciences 121 (suppl) 2-2, 2013.

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PL2 New twists in the saga of purinoceptors and pain

Michael W.Salter
Neurosciences & Mental Health Program, The Hospital for Sick Children, Department of Physiology, University of Toronto
Journal of Pharmacological Sciences 121 (suppl) 2-2, 2013.

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PL3 Transmission regulation of decision making: Pharmacogenetic approach

Shigetada Nakanishi
Osaka Bioscience Institute
Journal of Pharmacological Sciences 121 (suppl) 2-2, 2013.

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SL1 TARGETING RHO-MEDIATED TRANSCRIPTIONAL SIGNALING IN CANCER AND FIBROSIS

Richard R.Neubig1),2), Susan M.Wade1), Andrew J.Haak1), Scott D.Larsen3)
1)Department of Pharmacology, University of Michigan, 2)Center for the Discovery of New Medicines, University of Michigan, 3)Vahlteich Medicinal Chemistry Core, University of Michigan
Journal of Pharmacological Sciences 121 (suppl) 4-4, 2013.

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SL2 Herpetic pain and postherpetic neuralgia: Developmental mechanisms and therapeutic targets

Yasushi Kuraishi
Lab. Applied Pharmacol., Grad. Sch. Med. Pharm. Sci., Univ. Toyama
Journal of Pharmacological Sciences 121 (suppl) 4-4, 2013.

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SL3 G protein-coupled receptor allostery in the new millennium: Relevance to novel drug discovery

Arthur Christopoulos
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Dept. of Pharmacology, Monash University
Journal of Pharmacological Sciences 121 (suppl) 4-4, 2013.

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SL4 Application of iPS cells for cardiovascular medicine

Keiichi Fukuda, Tomohisa Seki, Shugo Tohyama, Shinsuke Yuasa
Dept. Cardiol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 4-4, 2013.

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SL5 Protection against adverse drug reactions by available medicines: countermeasures in cancer chemotherapy

Ryozo Oishi
Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 5-5, 2013.

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EAL Regulation of cell functions by spatiotemporal dynamics of Ca2+ signaling

Masamitsu Iino
Dept. Pharmacol., Grad. Sch. Med., The Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 8-8, 2013.

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AL1 Pharmacological study of mechanisms of neurotrophic factor action and its biosynthesis

Yutaro Obara
Department of Pharmacology, Yamagata University School of Medicine
Journal of Pharmacological Sciences 121 (suppl) 10-10, 2013.

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AL2 Pharmacological elucidation of the molecular mechanisms of mitochondria in drug-induced nephrotoxicity and the prevention

Takahisa Yano
Department of Pharmacy, Kyushu University Hospital
Journal of Pharmacological Sciences 121 (suppl) 10-10, 2013.

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AL3 Imaging analyses of ion channel molecule functions

Hisao Yamamura
Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University
Journal of Pharmacological Sciences 121 (suppl) 10-10, 2013.

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S1A-1-1 The role of microglia-synapse interactions in health and disease

Marie-Eve Tremblay
CHUQ-CHUL Res. Cent. and Dept. Mol. Med., Fac. Med., Univ. Laval
Journal of Pharmacological Sciences 121 (suppl) 12-12, 2013.

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S1A-1-2 Regulation of microglia-synapse interactions and synaptic strength by microglial circadian clock

Yoshinori Hayashi1), Hiroshi Nakanishi1),2)
1)Dept. Aging Sci and Pharmacolo., Faculy of Dent Sci., Kyushu Univ., 2)JST, CREST
Journal of Pharmacological Sciences 121 (suppl) 12-12, 2013.

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S1A-1-3 Microglial strategy in synapse remodeling of cortical circuits

Junichi Nabekura1),2), Hiroaki Wake3), Sun Kwang Kim1), Akiko Miyamoto1)
1)Natl. Inst. Physiol. Sci., 2)CREST JST, 3)NIBB
Journal of Pharmacological Sciences 121 (suppl) 12-12, 2013.

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S1A-1-4 Synaptic remodeling and neuron-to-glia communication

Schuichi Koizumi
Dept. Neuropharmacol, Grad. Sch. Med., Univ. Yamanashi
Journal of Pharmacological Sciences 121 (suppl) 12-12, 2013.

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S1B-2-1 Basis for circadian sensitivity of cancer cells to chemotherapeutic agents

Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo
Dept. Pharmaceutics, Grad. Sch. Pharmaceuti. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 13-13, 2013.

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S1B-2-2 Circadian regulation of allergic reaction by the mast cell clock

Atsuhito Nakao
Dept. Immunol., Faculty Med., Univ. of Yamanashi
Journal of Pharmacological Sciences 121 (suppl) 13-13, 2013.

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S1B-2-3 Toward understanding the pathophysiology and treatment of winter depression using an animal model

Shinobu Yasuo
Facul. Agr., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 13-13, 2013.

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S1B-2-4 In vivo monitoring of peripheral circadian clocks in the mouse

Yu Tahara, Shigenobu Shibata
Dept. of Physiol. and Pharm., Sch. of Adv. Sci. and Engi., Waseda Univ.
Journal of Pharmacological Sciences 121 (suppl) 13-13, 2013.

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S1C-3-1 Tumor-associated lymphatic vessels: More than an escape route

Melody A.Swartz
Dept. Bioengineering and Cancer Research
Journal of Pharmacological Sciences 121 (suppl) 14-14, 2013.

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S1C-3-2 Roles of vascular endothelial growth factor receptor-1 signaling in lungspecific tumor metastasis

Masabumi Shibuya
Dept. Gakubunkan Institute of Physiology and Medicine
Journal of Pharmacological Sciences 121 (suppl) 14-14, 2013.

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S1C-3-3 Roles of prostanoid receptor signaling in enhancement of tumor metastasis

Fumihiro Ogawa, Hideki Amano, Masataka Majima
Dept. Pharmacol., Kitasato Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 14-14, 2013.

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S1C-3-4 The role of peritoneal lymphatic system on the human peritoneal dissemination: Morphological analysis

Masahiro Miura1),2), Yutaka Yonemura2)
1)Department of Human Anatomy, Oita University, Faculty of Medicine., 2)NPO organization to Support Peritoneal Dissemination Treatment
Journal of Pharmacological Sciences 121 (suppl) 14-14, 2013.

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S1D-4-1 Brain Developmental Originhypothesis for psychoses by lack of polyunsaturated fatty acids

Motoko Maekawa1), Tetsuya Kimura2), Kei Hamazaki3), Akiko Watanabe1), Yoshimi Iwayama1), Hisako Ohba1), Yasuko Hisano1), Miki Bundo4), Kazuya Iwamoto4), Tetsuo Ohnishi1), Manabu Toyoshima1), Noriko Osumi5), Tadafumi Kato6), Akihiko Takashima2), Takeo Yoshikawa1)
1)Laboratory for Molecular Psychiatry, RIKEN BSI, 2)NCGG, 3)Toyama University, 4)Tokyo University, 5)Division of Developmental Neuroscience, Tohoku University, 6)Laboratory for Molecular Dynamics of Mental Disorders, RIKEN BSI
Journal of Pharmacological Sciences 121 (suppl) 15-15, 2013.

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S1D-4-2 Regulatory mechanisms of polyunsaturated fatty acids in differentiation of neural stem/progenitor cells

Masanori Katakura, Michio Hashimoto, Osamu Shido
Dept. Envi. Physiol. Shimane Uni. Fac. Med.
Journal of Pharmacological Sciences 121 (suppl) 15-15, 2013.

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S1D-4-3 The role of omega-3 fatty acids in mood disorder

Kei Hamazaki
Dept. Public Health, Univ. Toyama
Journal of Pharmacological Sciences 121 (suppl) 15-15, 2013.

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S1D-4-4 Possibility of preventing post-traumatic stress disorder with omega-3 fatty acid

Yutaka Matsuoka
Dept. Clin Epidemiol, TMC, NCNP, Dept. Psychiatry, National Disaster Medical Center, CREST, Japan Science and Technology Agency
Journal of Pharmacological Sciences 121 (suppl) 15-15, 2013.

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S1E-5-1 The involvement of ghrelin in gastrointestinal disorders

Haruko Hirayama1), Katsumi Mominoki1), Takahiko Shiina2), Yasutake Shimizu2)
1)Dept. Animal Resources, Okayama Univ., 2)Dept. Basic Vet. Sci., Lab. Physiol., Unit. Grad. Vet. Sci., Gifu Univ.
Journal of Pharmacological Sciences 121 (suppl) 16-16, 2013.

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S1E-5-2 Effect of stress-related peptide, CRF/urocortin, on colinic motility and mucus production: one of important mechanism of IBS

Hajime Ariga, Tomofumi Amano, Ayako Kurematsu, Shigeru Yamato
Div. Gastroenterol. NCNP
Journal of Pharmacological Sciences 121 (suppl) 16-16, 2013.

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S1E-5-3 The emerging role of interleukin-19 as inflammatory mediators in inflammatory bowel disease

Yasu-Taka Azuma, Tadayoshi Takeuchi
Lab. of Vet. Pharmacol., Division of Vet. Sci., Grad. Sch. Life Env. Sci., Osaka Prefecture Univ.
Journal of Pharmacological Sciences 121 (suppl) 16-16, 2013.

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S1E-5-4 The role of inflammatory cytokine TNF-α and microenvironment in mouse gastric tumorigenesis

Hiroko Oshima, Masanobu Oshima
Div. of Genetics, Cancer Res. Inst.
Journal of Pharmacological Sciences 121 (suppl) 16-16, 2013.

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S1C-6-1 The sturucture and function of kidney podocytes

Katsuhiko Asanuma
Division of Nephrology, Juntendo Univ. Faculty Med.
Journal of Pharmacological Sciences 121 (suppl) 17-17, 2013.

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S1C-6-2 Pathophysiological mechanism involved in mechanotransduction at podocyte TRPC6 channel signaling complex

Ryuji Inoue, Jun Ichikawa, Midori Nakagawa
Dept. Physiol., Grad. Sch. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 17-17, 2013.

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S1C-6-3 Role of cross-talk between Rho family small GTPases and steroid receptors in podocyte injury

Miki Nagase
Dept. Nephrol. and endocrinol, The Univ. Tokyo Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 17-17, 2013.

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S1C-6-4 iPSC technology-based research for the regeneration of glomerular podocyte and the development of novel disease models for podocyte-related disorders

Kenji Osafune
CiRA, Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 17-17, 2013.

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S1D-7-1 Role of astrocytes in the memory impairment in diabetes mellitus

Masahiro Ohsawa
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci. Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 18-18, 2013.

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S1D-7-2 How does diabetes mellitus increase the incidence of Alzheimer's disease?

Naoyuki Sato
Dept. Clinical Gene Therapy, Geriatric Medicine, Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 18-18, 2013.

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S1D-7-3 Central insulin resistance linking the pathogenesis of type 2 diabetes and brain dysfunctions

Hiroshi Tsuneki, Tsutomu Wada, Toshiyasu Sasaoka
Dept. Clin. Pharmacol., Univ. Toyama
Journal of Pharmacological Sciences 121 (suppl) 18-18, 2013.

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S1D-7-4 A novel preventive intervention for Alzheimer's disease based on its pathogenesis

Ayae Kinoshita
Dept. Human Health Sci., Kyoto Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 18-18, 2013.

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S1E-8-1 Mitohcondrial DNA as a novel target for cardiac pathological remodeling

Tomomi Ide
Dpt. Cardiovasc Med., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 19-19, 2013.

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S1E-8-2 Role of heme oxygenase-1 in inflammatory bowel disease

Yuji Naito, Tomohisa Takagi
Dept. Gastroenterology, Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 121 (suppl) 19-19, 2013.

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S1E-8-3 Periodontal disease as a disease of oxidative stress

Masaichi-Chang-il Lee
Department of Clinical Care Medicine, Division of Pharmacology & ESR laboratories Kanagawa Dental College
Journal of Pharmacological Sciences 121 (suppl) 19-19, 2013.

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S1E-8-4 Site-specific antioxidative therapy for kidney diseases

Aki Hirayama1),2), Toru Yoshitomi2), Yukio Nagasaki2)
1)Cent. Integrative Med., Tsukuba Univ. of Tech., 2)Materials Chem. & Biosci., University of Tsukuba
Journal of Pharmacological Sciences 121 (suppl) 19-19, 2013.

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S1C-9-1 The Role of Cell Adhesion Molecules in Neurites Recognition and Synaptogenesis of Mammalian Nervous System

Hideru Togashi
Div. Mol. Cell. Biol., Dept. Biochem. and Mol. Biol., Kobe Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 20-20, 2013.

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S1C-9-2 Role of the activity-regulated molecule in abnormal synapse formation

Kanato Yamagata
Neural Plasticity, Tokyo Metro. Inst. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 20-20, 2013.

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S1C-9-3 Antidepressant and synaptic remodeling by cell adhesion molecules

Hidekazu Tanaka
Biosystem Pharmacol., Osaka Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 20-20, 2013.

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S1C-9-4 Involvement of synaptic molecules in psychiatric disorders revealed by human genetics and studies using mouse models

Takeshi Sakurai
Medical Innovation Center, Kyoto Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 20-20, 2013.

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S1D-10-1 The development of post-ischemic glucose intolerance induced by cerebral neuronal damage and the involvement of communication system between brain and peripheral tissues

Shinichi Harada, Yui Yamazaki, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 21-21, 2013.

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S1D-10-2 The involvement of endoplasmic reticulum stress in neurodegeneration after transient global ischemia-reperfusion

Kumiko Ishige, Nobuhiro Osada, Yasuhiro Kosuge, Yoshihisa Ito
Lab. of Pharmacol., Sch. of Pharm., Nihon Univ.
Journal of Pharmacological Sciences 121 (suppl) 21-21, 2013.

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S1D-10-3 Mitochondrial uncoupling protein-2 in glutamate neurotoxicity

Takeshi Takarada, Ryo Fukumori, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 21-21, 2013.

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S1D-10-4 Neurogenesis signals activated following neurodegeneration: involvement of microglia

Masanori Yoneyama, Kiyokazu Ogita
Dept. Pharmacol., Setsunan Univ. Fac. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 21-21, 2013.

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S1E-11-1 Effect of continuous intravenous infusion of angiotensin II on Microminipig basilar arterial responsiveness

Atsushi Miyamoto1), MD.Zahorul Islam1), Hiroaki Kawaguchi2), Naoki Miura3), Emi Yamzaki-Himeno1), Mitsuya Shiraishi1), Noriaki Miyoshi2), Akihide Tanimoto4)
1)Dept. Vet. Pharmacol., Kagoshima Univ., 2)Lab. Vet. Histopathol., Kagoshima Univ., 3)Vet. Teaching Hosp., Kagoshima Univ., 4)Dept. Mol. and Cell. Pathol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ.
Journal of Pharmacological Sciences 121 (suppl) 22-22, 2013.

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S1E-11-2 Drug metabolizing enzyme activityes in Microminipigs compared with humans

Hiroshi Yamazaki
Lab. Drug Metab and Pharmacokinet, Showa Pharma Univ
Journal of Pharmacological Sciences 121 (suppl) 22-22, 2013.

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S1E-11-3 Endothelial dysfunction and evaluation of cardiovascular function

Yasukatsu Izumi1), Hiroaki Kawaguchi2), Masashi Tawa3), Junichi Fuchikami4), Mayuko Oka1), Masayuki Shiota1), Atsushi Sugiyama5), Tomio Okamura3), Hiroshi Iwao1)
1)Dept. Pharmacol., Osaka City Univ. Med. Sch., 2)Lab. Histopathol., Joint Faculty of Vet. Med., Kagoshima Univ., 3)Dept. Pharmacol., Shiga Univ. Med. Sci., 4)CIMIC BIORESEARCH CENTER, 5)Dept. Pharmacol., Faculty of Med., Toho Univ.
Journal of Pharmacological Sciences 121 (suppl) 22-22, 2013.

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S1E-11-4 Porcine Proteomics

Masaya Ikegawa
Dept. Genomic Medical Sciences, Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 121 (suppl) 22-22, 2013.

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S1C-12-1 Involvement of G protein-coupled receptor on proliferation and differentiation of pluripotent stem cells

Toshiaki Ishizuka, Haduki Goshima, Ayako Ozawa, Yasuhiro Watanabe
Dept. Pharmacol., National Defense Medical College
Journal of Pharmacological Sciences 121 (suppl) 23-23, 2013.

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S1C-12-2 Identification of an inhibitory chemokine for the CXCL12/CXCR4 axis to affect stem cell homeostasis

Takahiko Hara1), Kosuke Tanegashima1), Kenji Suzuki1), Kohei Tsuji2), Akira Shigenaga2), Takashi Nagasawa3), Akira Otaka2)
1)Stem Cell Project, Tokyo Metro. Inst. Med. Sci., 2)Mol. Des. Syn., Inst. Heal. Biosci., Grad. Sch. Pharma., Univ. Tokushima, 3)Dept. Immunobiol. Hematol., Inst., Frontier Med. Sci. Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 23-23, 2013.

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S1C-12-3 Signalings guiding differentiation of pluripotent stem cells into pancreatic beta cells

Shoen Kume
IMEG, Kumamoto University
Journal of Pharmacological Sciences 121 (suppl) 23-23, 2013.

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S1C-12-4 Therapeutic strategies for targeting receptors in cancer stem cells

Yasunari Kanda
Div. Pharmacol., Natl. Inst. Hlth. Sci.
Journal of Pharmacological Sciences 121 (suppl) 23-23, 2013.

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S2A-13-1 Analysis of molecular pathophysiology using activity manipulation and fate control of the hypothalamic neurons

Akihiro Yamanaka1),2),3), Tomomi Tsunematsu2), Sawako Tabuchi2)
1)Res. Inst. of Environ. Med., Nagoya Univ., 2)Nat. Inst. Physiol. Sci., Mtodaiji, 3)JST, PRESTO
Journal of Pharmacological Sciences 121 (suppl) 24-24, 2013.

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S2A-13-2 Exosomes as a novel tool for understanding molecular pathogenesis of neuronal diseases

Takahiro Ochiya
Dep. Molecular and Cellular Med, NCCRI, Tokyo
Journal of Pharmacological Sciences 121 (suppl) 24-24, 2013.

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S2A-13-3 Cell's first steps to raft formation and function as revealed by single-molecule imaging and tracking

Akihiro Kusumi
WPI-iCeMS and Inst. for Frontier Med. Sci. Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 24-24, 2013.

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S2A-13-4 Crucial role of epigenetic mechanisms in neurological and neurodegenerative diseases

Minoru Narita1), Daigo Ikegami1), Hiroyasu Sakai1), Toshikazu Ushijima2)
1)Dept. of Pharmacol., Hoshi Univ. Sch. of Pharm. and Pharmaceut. Sci., 2)Div. of Epigenomics, NCCRI
Journal of Pharmacological Sciences 121 (suppl) 24-24, 2013.

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S2B-14-1 Molecules and mechanisms decreasing and reinforcing the integrity of the blood-brain barrier

Maria.A.Deli
Group. Mol. Neurobiol., Hungarian Acad. Sci.
Journal of Pharmacological Sciences 121 (suppl) 25-25, 2013.

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S2B-14-2 Brain pericyte-derived soluble factors induce the blood-brain barrier dysfunction under pathological conditions

Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Hiroyuki Takahashi, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharm. Care Health Sci., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 25-25, 2013.

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S2B-14-3 Blood-brain barrier as a tumor microenvironment

Kunihiko Tanaka1), Keisuke Toyoda2), Shinsuke Nakagawa1),3), Masami Niwa1),3)
1)Dept. Pharmacol., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2)Dept. Neurosurg, Nagasaki Kawatana Medocal Center, 3)PharmaCo-Cell Co. Ltd.
Journal of Pharmacological Sciences 121 (suppl) 25-25, 2013.

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S2B-14-4 Brain barriers dysfunction and neurological diseases: The potential therapeutic approaches

Kouichi Itoh
Lab. Brain Sci., Kagawa Sch. Pharm. Sci., Tokushima Bunri Univ.
Journal of Pharmacological Sciences 121 (suppl) 25-25, 2013.

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S2C-15-1 Structural basis for molecular mechanism of calcium/proton exchanger transporter

Osamu Nureki1), Tomohiro Nishizawa1), Ryuichiro Ishitani1), Takahiro Iwamoto2)
1)Dept. of Biophys. and Biochem., Grad. Sch. of Sci., Univ. of Tokyo, 2)Dept. Pharma. Facul. Med. Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 26-26, 2013.

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S2C-15-2 Membrane targeting of Na+/Ca2+ exchanger via the conformational change of Ca2+ binding domains

Takahiro Iwamoto
Dept. Pharmacol., Fac. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 26-26, 2013.

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S2C-15-3 Zinc signal: the action of Zn ion controlling cellular and physiological events

Toshiyuki Fukada
RIKEN, RCAI, Cytokine, Osaka Univ. Grad. Med. Sch.
Journal of Pharmacological Sciences 121 (suppl) 26-26, 2013.

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S2C-15-4 Transport systems of cadmium and manganese in their target organs

Hitomi Fujishiro, Seiichiro Himeno
Faculty of Pharmaceutical Sciences, Tokushima Bunri Univ.
Journal of Pharmacological Sciences 121 (suppl) 26-26, 2013.

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S2D-16-1 Ca2+ mobilization mechanisms through TRPCs and NCX1 in regulation of vascular tonus

Satomi Kita, Takahiro Iwamoto
Dept. Pharmacol., Facul. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 27-27, 2013.

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S2D-16-2 Coronary microcirculation and hydrogen peroxide as an endothelium-derived hyperpolarizing factor

Toyotaka Yada1), Hiroaki Shimokawa2)
1)Dept. Medical Engineering., Kawasaki Med. Sch., 2)Dept. Cardiovasc Med., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 27-27, 2013.

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S2D-16-3 Significance of the Nitric Oxide Synthase System in the Pathogenesis of the Cardiovascular System

Masato Tsutsui1), Hiroaki Shimokawa2), Yutaka Otsuji3), Nobuyuki Yanagihara4)
1)Dept. Pharmacol, Grad Sch Med, Univ. of the Ryukyus, 2)Dept. Cardiol, Tohoku Univ. Grad Sch Med, 3)2nd Dept. Int. Med, Sch. Med., Univ. Occup. Environ. Health, 4)Dept. Pharmacol., Sch Med, Univ. Occup. Environ. Health
Journal of Pharmacological Sciences 121 (suppl) 27-27, 2013.

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S2D-16-4 Pathophysiological roles of adrenomedullin and its receptor activitymodifying system

Takayuki Shindo
Dept. Cardiovasc Res., Shinsyu Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 27-27, 2013.

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S2B-17-1 Glutamate spillover as a mediator for neuron-glia-vasculature interactions

Yohei Okubo, Masamitsu Iino
Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 28-28, 2013.

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S2B-17-2 Modes of glio-vasucular coupling revealed by molecular diffusion imagings inside and outside astrocytes

Mutsuo Nuriya, Masato Yasui
Dept. Pharmacol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 28-28, 2013.

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S2B-17-3 Functional imaging of astrocytes and blood flow

Sakiko Ujita, Saori Okada, Norio Matsuki, Yuji Ikegaya
Lab Chem Pharmacol, Grad Sch Pharm Sci, Univ Tokyo
Journal of Pharmacological Sciences 121 (suppl) 28-28, 2013.

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S2B-17-4 Repeated longitudinal imaging of Neuro-Glia-Vascular unit with two-photon microscopy in mouse cerebral cortex

Kazuto Masamoto1),2), Iwao Kanno2)
1)Cent. Frontier Sci. & Engineer. Univ. Electro-Communic., 2)MIC. NIRS
Journal of Pharmacological Sciences 121 (suppl) 28-28, 2013.

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S2D-18-1 Effects of pitavastatin on Japanese patients with chronic heart failure

Hiroyuki Takano
Dept. Mol. Cardiovasc. Pharm., Chiba Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 29-29, 2013.

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S2D-18-2 Efficacy of Ca channel blocker in diastolic heart failure

Hiroyuki Tsutsui
Dept. Cardiovasc. Med., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 29-29, 2013.

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S2D-18-3 Beneficial effects of a highly absorptive curcumin, Theracurmin, on patients with hypertensive heart disease

Tatsuya Morimoto1),2), Yoichi Sunagawa1),2), Yasufumi Katanasaka1),2), Hiromichi Wada2), Koji Hasegawa2)
1)Div. Mol. Med., Sch. Pharm. Sci., Univ. of Shizuoka, 2)Div. of Translational Res., Kyoto Medi. Cent., National Hospi. Organization
Journal of Pharmacological Sciences 121 (suppl) 29-29, 2013.

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S2D-18-4 Comparison of long- and short- acting diuretics in follow-up of patients with chronic heart failure

Tohru Masuyama1), Takeshi Tsujino2)
1)Cardiovasc Div., Dept. Int. Med., Hyogo Col. of Med., 2)Hyogo University of Health Sciences School of Pharmacy, Department of Pharmacy
Journal of Pharmacological Sciences 121 (suppl) 29-29, 2013.

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S2C-19-1 A new take on uptake: neurotransmitter transporters & the cellular mechanisms of amphetamine action

Susan G.Amara
National Institute of Mental Health, National Institutes of Health
Journal of Pharmacological Sciences 121 (suppl) 30-30, 2013.

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S2C-19-2 The role of glial glutamate transporters in the pathogenesis of neuropsychiatric disorders

Kohichi Tanaka
Dep. Mol. Neurosci., Inst. of Med. Res., Tokyo Medical & Dental Univ.
Journal of Pharmacological Sciences 121 (suppl) 30-30, 2013.

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S2C-19-3 Biochemistry and Pharmacology of Vesicular Neurotransmitter Transporters

Yoshinori Moriyama
Okayama Univ. Gra. Sch. Med. Den. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 30-30, 2013.

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S2D-20-1 Results of survey by JPMA: Animal models used in development of new pharmaceutical products

Takamichi Shigaki
JPMA
Journal of Pharmacological Sciences 121 (suppl) 31-31, 2013.

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S2D-20-2 Predictability of drug-induced emesis in humans from the rat, a species that does not exhibit vomiting

Hideo Fukui
Drug Safety Research Labs., Takeda Pharmaceutical Company Limited
Journal of Pharmacological Sciences 121 (suppl) 31-31, 2013.

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S2D-20-3 Animal models of mental disorders: Current situation and challenges

Tadafumi Kato
RIKEN Brain Science Institute, Lab. for Mol. Dynamics Mental Disord.
Journal of Pharmacological Sciences 121 (suppl) 31-31, 2013.

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S3A-21-1 CNS-mediated disintegration of homeostasis by chronic stress

Hiroshi Kiyama
Dept. Functional Anatomy & Neurosci., Nagoya Univ., Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 32-32, 2013.

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S3A-21-2 Involvement of spinally infiltrated immune cells in peripheral nerve injury-induced neuropathic pain

Takayuki Nakagawa, Kouichi Isami, Kayo Haraguchi, Kayoko Asakura, Hisashi Shirakawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharmaceu. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 32-32, 2013.

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S3A-21-3 Involvement of astroglial IFITM3 in neuronal impairments following neonatal immune challenge in mice

Kiyofumi Yamada, Daisuke Ibi, Taku Nagai
Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 32-32, 2013.

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S3A-21-4 Imaging of glia-neuron interaction using G-CaMP-type genetically encoded calcium indicators

Masamichi Ohkura
Saitama Univ. Brain Sci. Inst.
Journal of Pharmacological Sciences 121 (suppl) 32-32, 2013.

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S3C-22-1 The molecular function of the sigma-1 receptor

Teruo Hayashi
Seiwakai Nishikawa Hospital, National Institute on Drug Abuse, NIH
Journal of Pharmacological Sciences 121 (suppl) 33-33, 2013.

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S3C-22-2 Involvement of Sigma-1 receptor chaperone on the cytoprotective effects and neuroplasticity against dopamine

Tomohisa Mori1),2), Teruo Hayashi2),3), Masahiro Shibasaki1), Tsung-Ping Su2), Tsutomu Suzuki1)
1)Dept. Toxicol., Hoshi Univ. Sch. Pharmaceut. Sci., 2)Natinal Institute of Drag Abuse / National Institutes on Health, 3)Seiwakai Nishikawa Hospital
Journal of Pharmacological Sciences 121 (suppl) 33-33, 2013.

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S3C-22-3 Clinical implication of sigma-1 receptor ligands in neurodegenerative disease therapy

Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 33-33, 2013.

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S3C-22-4 Symptomatology and pharmacological treatment of Fronto-temporal dementia

Manabu Ikeda
Dept. Neuropsy, Facul. Life Sciences, Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 33-33, 2013.

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S3B-23-1 Pharmacology of Yokukansan on the ameliorative effects for the memory impairment and the behavioral and psychological symptoms of dementia in AD models

Kaori Kubota1), Ai Nogami1),2), Kotaro Takasaki1), Shutaro Katsurabayashi1), Kenichi Mishima1),2), Michihiro Fujiwara1), Katsunori Iwasaki1),2)
1)Dept. Neuropharmacol., Fac. Pharmac. Sci., Fukuoka Univ., 2)A.I.G. Institute for Aging and Brain Sciences
Journal of Pharmacological Sciences 121 (suppl) 34-34, 2013.

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S3B-23-2 Schizonepeta tenuifolia, a traditional herbal medicine, stimulates aquaporin3 expression, keratinocyte migration and wound repair

Yoichiro Isohama
Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharmac. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 34-34, 2013.

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S3B-23-3 Improvement effect of daikenchuto on morphine-induced constipation through the gastrointestinal peptide

Yuhki Sato
Dept. Pharm., Oita Univ Hosp.
Journal of Pharmacological Sciences 121 (suppl) 34-34, 2013.

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S3B-23-4 Basic evidence for efficacy of Goshajinkigan on oxaliplatin-induced neuropathy

Soichiro Ushio1), Nobuaki Egashira1),2), Kuniaki Tsutsumi1), Takehiro Kawashiri2), Ryozo Oishi1),2)
1)Fac. Sch. Pharm. Sci., Kyushu Univ., 2)Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 34-34, 2013.

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S3C-24-1 Anti-High Mobility Group Box-1 Antibody Therapy for Traumatic Brain Injury

Yu Okuma1),2), Isao Date2), Masahiro Nishibori1)
1)Dept. Pharmacol., Okayama Univ. Grad Sch. Med., 2)Dept. Neurosurg., Okayama Univ. Grad Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 35-35, 2013.

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S3C-24-2 Controlling RAGE and its associated diseases

Yasuhiko Yamamoto, Hiroshi Yamamoto
Dept. Biochem. & Mol. Vasc. Biol., Kanazawa Univ. Grad. Sch. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 35-35, 2013.

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S3C-24-3 Platform for drug discovery targeting HMGB1, AGEs-RAGE response

Shuji Mori1), Takao Toyomura1), Hideo Takahashi2)
1)Sch. Pharm., Shujitsu Univ., 2)Dept. Pharmacol., Fac. Med., Kinki Univ.
Journal of Pharmacological Sciences 121 (suppl) 35-35, 2013.

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S3C-24-4 Roles of thrombomodulin as nuclear safeguard

Takashi Ito
Dept. Systems Biology in Thromboregulation, Kagoshima Univ.
Journal of Pharmacological Sciences 121 (suppl) 35-35, 2013.

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S3C-25-1 Current status and future perspectives on the experimental practice of pharmacology in the new pharmaceutical education system

Tsuneyuki Yamamoto
Dept., Pharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.
Journal of Pharmacological Sciences 121 (suppl) 36-36, 2013.

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S3C-25-2 Trials in method of pharmacological practice and the results

Mitsuru Kawaguchi, Kohei Sawaki, Takashi Shinomiya, Migiwa Okubo, Masato Watanabe, Hisako Wang, Toshihiko Kawano, Masao Kujirai
Dept. Pharmacol., Tokyo Dent. Coll.
Journal of Pharmacological Sciences 121 (suppl) 36-36, 2013.

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S3C-25-3 Computer-based alternative to the use of experimental animals in pharmacological education

Masahiro Oike
Dept. Pharmacol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 36-36, 2013.

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S3C-25-4 Encouragement of role-play: effectiveness of the student role-play in the pharmacology education at the school of Medicine, Dentistry and Pharmaceutical Sciences

Toshihiko Yanagita1), Naohiko Anzai2), Nobuyuki Yanagihara3), Tetsumi Irie4), Takahiro Iwamoto5), Jun Yamazaki6), Mitsuru Irikura4), Yoichi Ishitsuka4), Takayuki Nemoto1), Chihiro Sugita1), Shigeyuki Nakano7), Manabu Murakami1)
1)Dept. Pharmacol., Miyazaki Med. Coll., Univ. Miyazaki, 2)Dept. Pharmacol., Dokkyo Med. Univ., 3)Dept. Pharmacol., Univ. Occup. & Env. Health, Sch. Med., 4)Dept. Clin. Chem. Inform., Grad. Sch. Pharm. Sci., Kumamoto Univ., 5)Dept. Pharmacol., Faculty of Med., Fukuoka Univ., 6)Dept. Physiol. Sci. Mol. Biol., Fukuoka Dent. Coll., 7)Dept. Pharmaceut. Med. Commun., Oita Univ. Faculty of Med.
Journal of Pharmacological Sciences 121 (suppl) 36-36, 2013.

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S3D-26-1 Treatment for pulmonary arterial hypertension at turning point

Hiroshi Watanabe
Dept. Clin. Pharmacol. Ther., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 37-37, 2013.

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S3D-26-2 Anti-proliferative and pro-apoptotic effects of imatinib on pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

Kazufumi Nakamura, Satoshi Akagi, Hiroshi Ito
Department of Cardiovascular Medicine, Okayama University Hospital
Journal of Pharmacological Sciences 121 (suppl) 37-37, 2013.

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S3D-26-3 Role of Rho-kinase Pathway in Pulmonary Arterial Hypertension

Yoshihiro Fukumoto, Hiroaki Shimokawa
Dept. Cardiovasc., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 37-37, 2013.

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S3D-26-4 A new strategy for treatment of pulmonary hypertension with thrombin receptor as a therapeutic target

Katsuya Hirano
Div. Mol. Cardiol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 37-37, 2013.

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S3B-27-1 Taste perception and food intake

Noriatsu Shigemura1), Ryusuke Yoshida1), Keiko Yasumatsu1), Tadahiro Ohkuri2), Keisuke Sanematsu1), Masafumi Jyotaki1), Mayu Niki1), Yuzo Ninomiya1)
1)Sect. Oral Neurosci., Grad. Sch. Dental Sci., Kyushu Univ., 2)Monell Chemical Senses Center
Journal of Pharmacological Sciences 121 (suppl) 38-38, 2013.

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S3B-27-2 Decline in oronasal functions in cancer patients

Misako Kawai
Institute for Innovation, Ajinomoto Co., Inc.
Journal of Pharmacological Sciences 121 (suppl) 38-38, 2013.

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S3B-27-3 Current Status of and Measures for Taste Disorder

Setsuko Kuwahara
National Cancer Center Hospital
Journal of Pharmacological Sciences 121 (suppl) 38-38, 2013.

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S3B-27-4 Oral diagnosis and oral medicine for taste disorder

Takashi Sasano, Sizuko Satoh-Kuriwada, Noriaki Shoji
Dept. Oral Diagnosis, Tohoku Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 38-38, 2013.

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S3C-28-1 Pharmacology for pharmaceutical care

Yuji Yoshiyama
Div. Clinical Pharmacy, Kitasato Univ., Sch. Pharmacy
Journal of Pharmacological Sciences 121 (suppl) 39-39, 2013.

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S3C-28-2 Pharmacology knowledge for Pharmaceutical Care

Susan Vos
Univ. of Iowa College of Pharmacy
Journal of Pharmacological Sciences 121 (suppl) 39-39, 2013.

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S3C-28-3 Pharmacological knowledge for pharmacist in the field of sport

Kumiko Kasashi
Dept. Pharmacy, Hokkaido Univ. Hospital
Journal of Pharmacological Sciences 121 (suppl) 39-39, 2013.

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S3C-28-4 "Scientific effect" (pharmacology, yakuri) and "traditional effect" (yakunou) of Kampo medicines and its herbal components

Toshiaki Makino
Dept. of Pharmacognosy, Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 39-39, 2013.

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S3D-29-1 Review of beneficial effects induced by Kampo medicines

Hiroyasu Satoh1), Tadaaki Miyazaki2)
1)Health Life Sci., Shitenno Univ., 2)Probio., Inst. Genet. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 40-40, 2013.

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S3D-29-2 Artemisinin: a natural product for fight against cancer

Tomoka Takatani-Nakase, Koichi Takahashi
Dept. Pharmaceut., Sch. Pharm. and Pharmaceut. Sci., Mukogawa Women's Univ.
Journal of Pharmacological Sciences 121 (suppl) 40-40, 2013.

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S3D-29-3 Effect of Goreisan on the urinary concentrating ability and the expressions of aquaporins in 5/6 nephrectomized rats

Michiko Jo
Inst. Nat. Med., Univ. Toyama
Journal of Pharmacological Sciences 121 (suppl) 40-40, 2013.

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S3D-29-4 The efficacy of Kampo medicine for the diseases and pains of joints

Yuki Kishida
Dept. Kampo Medicine., Osaka Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 40-40, 2013.

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YS1D-1-1 Axonal regeneration: A new strategy for treating multiple sclerosis

Rieko Muramatsu, Toshihide Yamashita
Dept. Mol. Neurosci., Grad. Sch. of Med., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 42-42, 2013.

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YS1D-1-2 Spatio-temporal imaging of spinal activities in the rat model of pain hypersensitivity

Kan Miyoshi, Tetsuo Fukuoka, Koichi Noguchi
Dept. Anatomy & Neurosci., Hyogo Col. Med.
Journal of Pharmacological Sciences 121 (suppl) 42-42, 2013.

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YS1D-1-3 Translational research for therapeutic strategy of Alzheimer's disease

Kazuyuki Takata1), Yoshihisa Kitamura1), Shun Shimohama2), Eishi Ashihara1)
1)Dept. Clin. Transl. Physiol., Kyoto Pharm. Univ., 2)Dept. Neurol., Sapporo Med. Univ., Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 42-42, 2013.

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YS1D-1-4 New approach for overcoming the cerebrovascular disorders

Toshiaki Kume1), Masahito Sawahata1), Kazuya Taguchi1), Yasuhiko Izumi1), Akinori Akaike1),2)
1)Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 2)Grad. Sch. Pharmaceut. Sci., Nagoya Univ.
Journal of Pharmacological Sciences 121 (suppl) 42-42, 2013.

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YS2C-2-1 Localized calcium signals in astrocytes revealed by genetically encoded calcium indicators

Eiji Shigetomi1),2), Olan Jackson-Weaver2), Thomas O'Dell2), Khakh Baljit2),3)
1)Dept. Pharmacol., Univ. Yamanashi, 2)Dept. Physiol., David Geffen Sch. Med., UCLA, 3)Dept. Neurobiol., David Geffen Sch. Med., UCLA
Journal of Pharmacological Sciences 121 (suppl) 43-43, 2013.

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YS2C-2-2 Kinetics analysis of Pl(4, 5)P2 and DAG dynamics and DAGsensitive-TRPCcurrents

Masayuki Mori1), Kyohei Itsuki1),2), Yuko Imai1),2), Yasushi Okamura3), Ryuji Inoue1)
1)Dept. of Physiol., Fukuoka Univ. School of Med., 2)Faculty of Dental Science, Kyushu Univ., 3)Dept. of Physiol., Osaka Univ. School of Med.
Journal of Pharmacological Sciences 121 (suppl) 43-43, 2013.

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YS2C-2-3 Regulation of cardiac L-type Ca2+ currents through a non-genomic action of sex hormones

Junko Kurokawa, Masami Kodama, Sayuri Goryoda, Tetsushi Furukawa
Dept. Pharmacol., MRI
Journal of Pharmacological Sciences 121 (suppl) 43-43, 2013.

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YS2C-2-4 Diversity of the intracellular local Ca2+ signal mechanisms in the heart

Iyuki Namekata1), Toru Kawanishi2), Hikaru Tanaka1)
1)Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci., 2)Nat. Inst. Health Sci
Journal of Pharmacological Sciences 121 (suppl) 43-43, 2013.

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CS1B-1-1 Using direct reprogramming of human fibroblasts to understand risk SNPs associated with psychiatric disorders including schizophrenia

Takao Yoshimizu1),2),3), Li-Huei Tsai2),3)
1)Mol. Function & Pharmacol. Labs., Taisho Pharmaceutical Co., Ltd., 2)Picower Inst. for Learning and Memory, MIT, 3)Stanley Ctr. for Psychiatric Res., Broad Inst.
Journal of Pharmacological Sciences 121 (suppl) 46-46, 2013.

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CS1B-1-2 Strategy of target validation from a novel risk factor of schizophrenia / bipolar disorder

Shinichi Miyake1), Katsunori Tajinda1),2), Mitsuyuki Matsumoto1)
1)CNS, Astellas Research Institute of America, LLC, 2)Astellas Pharma Inc, Drug Discovery Research Pharmacology Research Labs, Neuroscience
Journal of Pharmacological Sciences 121 (suppl) 46-46, 2013.

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CS1B-1-3 Cuprizone short-term exposure: astrocytic IL-6 activation and schizophrenia-like behavior

Tomoaki Tezuka
Pharmacology Research Laboratories I, Mitsubishi Tanabe Pharma Corporation
Journal of Pharmacological Sciences 121 (suppl) 46-46, 2013.

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CS1B-1-4 Pharmacological characterization of metabotropic glutamate receptor 1 antagonist for the treatment of schizophrenia

Shunsuke Maehara
Biology Laboratory, Discovery Research, Mochida Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 46-46, 2013.

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CS3B-2-1 Anti-rheumatic effects of T-614(Iguaratimod), a novel DMARD

Kenzo Muramoto1), Keiichi Tanaka2)
1)Tsukuba research Laboratories, Eisai Co., Ltd., 2)Research Laboratories, Toyama Chemical Co. Ltd.
Journal of Pharmacological Sciences 121 (suppl) 47-47, 2013.

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CS3B-2-2 ASP015K: A Novel Janus Kinase Inhibitor Demonstrated Potent Efficacy in Adjuvant-Induced Arthritis and Chronic Oxazolone-Induced Dermatitis Model in Rats

Masamichi Inami, Shunji Yamazaki, Misato Ito, Noboru Chida, Tomonori Nakanishi, Shinsuke Ooshima, Kaori Hanaoka, Keiko Ohkubo, Shohei Shirakami, Takayuki Inoue, Yasutomo Fujii, Yasuyuki Higashi
Pharmacology Research Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 121 (suppl) 47-47, 2013.

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CS3B-2-3 Proteasome inhibitor for antibody-mediated disease therapy

Yasuo Itomi
Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company Ltd
Journal of Pharmacological Sciences 121 (suppl) 47-47, 2013.

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CS3B-2-4 Target identification of novel orally active anti-inflammatory compound: Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) inhibitor

Ayatoshi Andou1), Takashi Yamamoto1), Eviryanti Agung1), Yukie Seki1), Hikaru Nishio1), Sen Takeshita1), Nobuhiko Hayakawa1), Masatsugu Noguchi1), Ryohei Yokoyama1), Manami Shuto1), Misato Noguchi1), Yoichiro Shima1), Tohru Natsume2), Shunsuke Kageyama1), Hiroyuki Eda1), Makoto Shiozaki1), Masataka Shoji1)
1)AJINOMOTO PHARMACEUTICALS CO., LTD., Research Center, 2)Biomedicinal Information Research Center, AIST
Journal of Pharmacological Sciences 121 (suppl) 47-47, 2013.

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CS3B-3-1 Emerging Hormonal Drugs for Prostate Cancer Treatment

Hisanori Matsui
Oncology DDU Takeda Pharmaceuticla Company
Journal of Pharmacological Sciences 121 (suppl) 48-48, 2013.

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CS3B-3-2 Discovery and research of a novel dual PI3K/mTOR inhibitor, DS-7423

Yoshinobu Shiose
Oncology Research Labs., Daiichi Sankyo CO., LTD.
Journal of Pharmacological Sciences 121 (suppl) 48-48, 2013.

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CS3B-3-3 Translational research of anti-cancer developmental drug, lenvatinib for personalized medicine

Junji Matsui
Eisai, Oncology-PCU
Journal of Pharmacological Sciences 121 (suppl) 48-48, 2013.

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CS3B-3-4 Drug Development of Mogamulizumab, anti-CCR4 antibody, for Adult T-cell Leukemia-Lymphoma

Toshihiko Ishii1), Takeshi Takahashi1), Shiro Akinaga1), Takashi Ishida2), Kouji Matsushima3), Ryuzo Ueda4)
1)Pharm. Lab., Res Div., Kyowa Hakko Kirin Co., Ltd., 2)Medical Oncol. and Immunol., Nagoya City Univ. Sch. Medical Sciences, 3)Molecular Preventive Medicine, Grad. Sch. Med., Univ. of Tokyo, 4)Immunol., Oncol., Aichi Medical Univ.
Journal of Pharmacological Sciences 121 (suppl) 48-48, 2013.

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AS1-1 Academia drug discovery on the project "Platform for drug discovery, informatics and structural life science"

Tetsuo Nagano
Grad. Sch. Pharm. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 50-50, 2013.

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AS1-2 Chemical compound screening base formation to attempt intractable diseases in Hokkaido

Hiroyoshi Ariga
Facul. Pharmaceut., Hokkaido Uni.
Journal of Pharmacological Sciences 121 (suppl) 50-50, 2013.

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AS1-3 The performance of Tohoku University on the innovation of academically driven drug discovery using chemical library

Akira Sugawara1), Junken Aoki2), Takashi Dan3), Ritsuko Shimizu4), Norio Suzuki5), Kuniyuki Kano2), Shinichi Okudaira2), Akiko Hakoda1), Hiroshi Kaneko4), Takafumi Uchida6), Toru Nakazawa7), Takayuki Doi8), Toshio Miyata3), Yoshiteru Oshima9), Masayuki Yamamoto10)
1)Dept. Mol. Endo., Tohoku Univ. Grad. Sch. Med., 2)Dept. Mol. Cell. Biochem., Tohoku Univ. Grad. Sch. Pharm. Sci., 3)Dept. Mol. Med. Ther., Tohoku Univ. Grad. Sch. Med., 4)Dept. Mol. Hematol., Tohoku Univ. Grad. Sch. Med., 5)Dept. Interdisciplinary Med. Sci., Tohoku Univ. Grad. Sch. Med., 6)Dept. Mol. Enzymol., Tohoku Univ. Grad. Sch. Agri. Sci., 7)Dept. Ophthal., Tohoku Univ. Grad. Sch. Med., 8)Dept. Heterocycl. Chem., Tohoku Univ. Grad. Sch. Pharm. Sci., 9)Dept. Nat. Prod. Chem., Tohoku Univ. Grad. Sch. Pharm. Sci., 10)Dept. Med. Biochem., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 50-50, 2013.

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AS1-4 One-stop drug development at Kyoto University

Masatoshi Hagiwara
Dept. Anat. & Dev. Biol., Grad. Sch. Med., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 50-50, 2013.

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AS1-5 Hit-to-Lead: Activities of the Center for Drug Discovery and Development at Osaka University

Tadayuki Uno
Grad. Sch. Pharm. Sci., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 51-51, 2013.

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AS1-6 Academic Drug Discovery in Kyushu University

Kazuhide Inoue
Dept. Mol & System Pharmacol., Fuculty Pharmaceu. Sci. Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 51-51, 2013.

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AS1-7 Therapeutic Innovation at Nagasaki University: Focus on Infections, Radiation-Induced Damage, and Chronic Pain

Hiroshi Ueda1),2), Yoshimasa Tanaka2)
1)Dept. Mol. Pharmacol. Neurosci., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2)Center Ther. Innov., Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 121 (suppl) 51-51, 2013.

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SS1-1 A practice on pharmacokinetics for undergraduate medical students using a computer simulation model

Ichie Hara, Hiroaki Suzuki, Masaaki Matsuoka
Dept. Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 54-54, 2013.

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SS1-2 Trial of practical pharmacotherapy education using role-play with third-year medical students act as physicians and patients

Toshihiko Yanagita1), Naohiko Anzai2), Nobuyuki Yanagihara3), Takahiro Iwamoto4), Yumiko Toyohira2), Satomi Kita4), Yusuke Gotoh4), Kohsuke Uchida4), Takayuki Nemoto1), Shigeyuki Nakano5), Manabu Murakami1)
1)Dept. Pharmacol., Miyazaki Med. Coll., Univ. Miyazaki, 2)Dept. Pharmacol., Dokkyo Med. Univ., 3)Dept. Pharmacol., Univ. Occup & Env. Health, Sch. Med., 4)Dept. Pharmacol., Faculty of Med., Fukuoka Univ., 5)Dept. Pharmaceut. Med. Commun., Oita Univ. Faculty of Med.
Journal of Pharmacological Sciences 121 (suppl) 54-54, 2013.

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SS1-3 Innovative visible and tangible medical education using tablet information device and 3D printer

Maki Sugimoto
Kobe University Graduate School of Medicine
Journal of Pharmacological Sciences 121 (suppl) 54-54, 2013.

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SS1-4 How to teach and train medical students for the process of rational prescribing in Japan?

Eiji Uchida
Office for Promoting Medical Research
Journal of Pharmacological Sciences 121 (suppl) 54-54, 2013.

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JS1-1 Overview of the structure-function relationship and the regulation mechanisms of ATP receptor channel P2X

Yoshihiro Kubo, Batu Keceli
Div. Biophys. & Neurobiol., Natl. Inst. Physiol. Sci.
Journal of Pharmacological Sciences 121 (suppl) 56-56, 2013.

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JS1-2 Molecular dissection of the presynaptic P2X receptor subtypes in the brain

Fusao Kato1), Tomoyasu Tamura1), Chiaki Yamada-Nakayama1), Eiji Shigetomi2)
1)Dept., Neurosci., Jikei Univ. Sch. Med., 2)Dept Pharmacol, Fac Med, Univ of Yamanashi
Journal of Pharmacological Sciences 121 (suppl) 56-56, 2013.

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JS1-3 Endothelial P2X4 receptor-mediated regulation of vascular functions

Kimiko Yamamoto1), Joji Ando2)
1)Lab. System Physiol., Grad. Sch. of Med., Univ. Tokyo, 2)Lab. Biomed. Eng., Sch. Med., Dokkyo Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 56-56, 2013.

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JS1-4 Regulation of microglial P2X4 receptor trafficking between lysosome and cell surface

Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Tomohiro Yamashita, Kazuhide Inoue
Dept. Mol. Sys. Pharmacol., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 56-56, 2013.

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JS1-5 Regulation of P2X7 Receptor-Mediated Inflammatory Functions by Co-expression of P2X4 Receptor in Macrophages

Mitsutoshi Tsukimoto1), Hitoshi Harada2), Shuji Kojima1)
1)Fac. of Pharmaceutical Sciences, Tokyo University of Science, 2)Fac. of Pharmaceutical Sciences, Suzuka University of Medical Science
Journal of Pharmacological Sciences 121 (suppl) 57-57, 2013.

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AO1F-1-1 Contribution of Cathepsin S (CatS) to the development of neuropathic pain through recruiting peripheral immune cells

Xinwen Zhang1), Yoshinori Hayashi1), Zhou Wu1), Ryo Okada1), Hiroshi Nakanishi1),2)
1)Dept. Aging Sci. and Pharmacol. Sci., Kyushu Univ., Facl. of Dent. Sci., 2)CREST, Japan Science and Technology Agency
Journal of Pharmacological Sciences 121 (suppl) 60-60, 2013.

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AO1F-1-2 Angiogenic macrophage contributes to neuropathic pain associated with peripheral neuroinflammation

Norikazu Kiguchi, Yuka Kobayashi, Shiroh Kishioka
Dept. Pharmacol., Wakayama Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 60-60, 2013.

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AO1F-1-3 Involvement of phosphorylation of μ-opioid receptors on the bilateral reduction of morphine analgesia in inflammatory pain state

Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
Dept. Physiol. Anat. Tohoku Pharmaceut. Univ.
Journal of Pharmacological Sciences 121 (suppl) 60-60, 2013.

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AO1F-1-4 Conditional deletion of STAT3 in astrocytes suppresses reactive astrocytes after nerve injury and neuropathic pain

Yuta Kohro1), Makoto Tsuda1), Emi Sakaguchi1), Hidetoshi Tozaki-Saitoh1), Hideyuki Okano2), Kazuhide Inoue1)
1)Dept. Mol. Syst. Parmacol., Grad. Sch. Parm. Sci., Kyushu Univ., 2)Dept. Physiol., Sch. Med., Keio Univ.
Journal of Pharmacological Sciences 121 (suppl) 60-60, 2013.

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AO1F-1-5 Molecular Basis for Circadian Regulation of Neuropathic Pain in Mice

Naoki Kusunose, Satoru Koyanagi, Kengo Hamamura, Takahiro Akamine, Kazuhiro Sasaki, Shoya Shiromizu, Naoya Matsunaga, Shigehiro Ohdo
Dept. Pharmaceuti., Grad. Sch., Pharmaceuti. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 61-61, 2013.

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AO1F-1-6 Roles of neuropeptidergic transmissions within the dorsolateral bed nucleus of the stria terminalis in pain-induced aversion

Chikashi Maruyama1), Soichiro Ide1), Atsushi Ohno1), Ryuta Tamano1), Kana Koseki1), Tomonori Naka1), Satoshi Deyama1), Mitsuhiro Yoshioka2), Masabumi Minami1)
1)Dept Pharmacol, Grad Sch Pharm Sci, Hokkaido Univ, 2)Dept Neuropharmacol, Grad Sch Med, Hokkaido Univ
Journal of Pharmacological Sciences 121 (suppl) 61-61, 2013.

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AO1G-2-1 Nuclear GAPDH accelerates the activation of PARP-1 in the brain of MCAO rat

Takeya Kubo1), Hidemitsu Nakajima1), Masanori Itakura1), Neelam Shahani2), Yasu-Taka Azuma1), Akira Sawa2), Tadayoshi Takeuchi1)
1)Lab. of Pharmacol., Osaka Pref. Univ., 2)Dept. Psychiatry., Johns Hopkins Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 61-61, 2013.

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AO1G-2-2 Proteomic analysis of S-nitrosylation induced by 1-methyl-4-phenylpyridinium (MPP+)

Akira Komatsubara1),2), Kentaro Ozawa1), Hiroto Kawafune1),2), Hiroki Tsumoto3), Jing Zhao1), Yoji Kyotani1), Satoyasu Ito1), Kosuke Nagayama1), Yuichi Tsuji1), Masanori Yoshizumi1)
1)Dept. Pharmacol., Nara Medical Univ., 2)Dept. Pharm., Kyoto Univ., 3)Dept. Pharm., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 61-61, 2013.

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AO1G-2-3 Upregulation by middle cerebral artery occlusion of lfrd1 expression in murine brain

Miki Kou, Takeshi Takarada, Ryo Fukumori, Ryota Nakazato, Miho Hida, Yukio Yoneda
Dept. Pharmaceutical Sciences., Kanazawa Univ. Sch. Phar.
Journal of Pharmacological Sciences 121 (suppl) 62-62, 2013.

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AO1G-2-4 Inactivation of Sp1 by transglutaminase 2 is implicated in negative regulation of PAC1 gene expression

Ayako Miura1), Yuki Kambe1), Kazuhiko Inoue1), Takashi Kurihara1), Hideki Tatsukawa2), Souichi Kojima2), Atsuro Miyata1)
1)Dept. of Pharmacol., Grad. Sch. of Med and Dent. Sci., Kagoshima Univ., 2)Molecular Ligand Biology Research, RIKEN
Journal of Pharmacological Sciences 121 (suppl) 62-62, 2013.

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AO1G-2-5 Insolubilization of an ubiquitin ligase HRD1 triggered by oxidative stress may be involved in Alzheimer's disease pathogenesis

Ryo Saito1), Masayuki Kaneko1),3), Koichi Kawada1), Yasuyuki Nomura2), Yasunobu Okuma1)
1)Dept. Pharmacol., Chiba Inst. Sci., 2)Lab. Pharmacotherapeutics, Yokohama Col. Pharm., 3)Lab. Med. Therap. and Mol. Therap., Gifu Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 62-62, 2013.

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AO1H-3-1 Induction of IL-10-pruducing Tr1 cells and/or Th1 cells for application to antigen-specific immunotherapy for atopic diseases

Shinya Fujii1), Maki Kishima1), Keiichi Ishihara2), Satoshi Akiba2), Masanori Fujii1), Susumu Ohya1), Takeshi Nabe1)
1)Dept. Pharmacol., Kyoto Pharm. Univ., 2)Dept. Pathol. Biochem., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 62-62, 2013.

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AO1H-3-2 Roles of mDia, a Rho effector and formin family actin-nucleator, in T cell development

Dean Thumkeo, Akira Nomachi, Kiyoshi Tohyama, Ryota Shinohara, Takako Hirata, Toshimasa Ishizaki, Shuh Narumiya
Dept. Pharmacol., Kyoto Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 63-63, 2013.

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AO1H-3-3 Effects of pioglitazone pretreatment on sepsis-induced visceral adipose tissue inflammation and lung damage

Masahiko Kutsukake1), Makoto Kobayashi1), Kazuhiro Tamura1), Takeshi Matsutani2), Akihisa Matsuda2), Eiji Uchida2), Mikihiro Yoshie1), Eiichi Tachikawa1)
1)Dept. Endocr. Neural Pharmacol., Tokyo Univ. Pharm. & Life Sci., 2)Div. Surg. Organ Function Biol. Regulation, Nihon Med. Sch.
Journal of Pharmacological Sciences 121 (suppl) 63-63, 2013.

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AO1H-3-4 Protective role of alveolar macrophage in acute lung injury caused by selective ablation of alternative activated alveolar macrophage (M2) co-expressing CD206 and diphtheria toxin receptor

Kenta Kambara1),2), Kengo Tomita1), Michinori Takashina1), Kumiko Taguchi1), Hiroki Yokoo1), Ryuuji Hayasi2), Kazuyuki Tobe2), Yuichi Hattori1)
1)Dept. Mol. Pharmacol. Graduate. Sch. Med. Pharm. Sci. Univ. of Toyama, 2)Dept. Internal Medicine Firt, Graduate. Sch. Med. Pharma. Sci. Univ. of Toyama
Journal of Pharmacological Sciences 121 (suppl) 63-63, 2013.

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AO1H-3-5 CCl4-induced acute liver failure is accelerated in ovariectomized mice

Satoru Mitazaki1), Natsumi Kotajima1), Sakiko Matsuda1), Miwako Suto2), Naho Kato2), Kouichi Hiraiwa2), Sumiko Abe1)
1)Takasaki University of Health and Welfare, 2)Dept. Legal Med., Fukushima Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 63-63, 2013.

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AO1H-3-6 Effect of quercetin on streptozotocin-induced diabetic mice

Masashi Hattori1), Hiroyuki Mizuguchi1), Yuko Baba1), Syohei Ono1), Zhang Qian1), Makoto Kobayashi1), Naozumi Ishimaru2), Yoshiaki Kitamura3), Noriaki Takeda3), Hiroyuki Fukui1)
1)Dept. of Mol. Pharmacol., Inst. of Health Biosciences, The Univ. of Tokushima, Grad. Sch., 2)Dept. of Oral Mol. Pathol., Inst. of Health Biosciences, The Univ. of Tokushima, Grad. Sch., 3)Dept. of Otolaryngol., Inst. of Health Biosciences, The Univ. of Tokushima, Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 64-64, 2013.

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AO1F-4-1 Girdin is implicated in neuronal plasticity through its phosphorylation

Tsuyoshi Nakai1), Taku Nagai1), Motoki Tanaka2), Naoya Asai3), Atsushi Enomoto3), Masahiro Sokabe2), Masahide Takahashi3), Kiyofumi Yamada1)
1)Dept. Neuropsychophamacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 2)Dept. Physiol., Nagoya Univ. Grad. Sch. Med., 3)Dept. Pathol., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 64-64, 2013.

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AO1F-4-2 Voltage-dependent calcium channel β4 subunit directly couples electrical activity to gene expression

Seishiro Sawamura1), Shigeki Kiyonaka1),2), Takafumi Miki1), Satoshi Akiyama1), Michel Ronjat3), Michel De.Waard3), Yasuo Mori1),2)
1)Kyoto Univ., Dept. Synthet. Chem. & Biol. Chem., Grad. Sch. Engineer., 2)Kyoto Univ., Dept. Technol. & Ecol., 3)Inserm U836, Grenoble Institute of Neuroscience
Journal of Pharmacological Sciences 121 (suppl) 64-64, 2013.

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AO1F-4-3 Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor, regulates ligand binding of D1 receptors, and stimulates D1-induced cAMP production through Gβγ in HEK293T cells

Aliza Ehrlich, Shiho Kitaoka, Tomoyuki Furuyashiki, Shuh Narumiya
Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 64-64, 2013.

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AO1F-4-4 Fatty acid-binding protein 3 involved in neuronal transmission and emotional behavior

Yui Yamamoto1),2), Yuji Owada1), Kohji Fukunaga2)
1)Dept. Organ Anatomy, Yamaguchi Univ. Grad. Sch. Med., 2)Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 65-65, 2013.

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AO1F-4-5 Unique neural characteristics of GAD67-containing 5-HTergic neurons in the rat dorsal raphe nucleus

Hiroki Shikanai1),2), Takayuki Yoshida2), Kohtarou Konno3), Miwako Yamasaki3), Takeshi Izumi2), Yu Ohmura2), Keiichi Shimamura1), Masahiko Watanabe3), Mitsuhiro Yoshioka2)
1)Dept. Phamacol., Fac. Pharma, Sci., Health Sci. Univ. of Hokkaido, 2)Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. of Med., 3)Dept. Anatomy., Hokkaido Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 121 (suppl) 65-65, 2013.

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AO1G-5-1 Cognitive enhancer ST101 improves cognitive impairment in schizophrenic model rats

Yasushi Yabuki1), Osamu Nakagawasai2), Koichi Tan-No2), Kohji Fukunaga1)
1)Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci., 2)Dept. Pharmacol., Tohoku Pharmaceu. Univ.
Journal of Pharmacological Sciences 121 (suppl) 65-65, 2013.

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AO1G-5-2 The involvement of hypothalamic and mesolimbic opioid systems in regulating food intake

Chrismawan Ardianto1), Hiroko Ikeda1), Takahiro Ohashi1), Megumi Ikegami1), Hiroshi Nagase2), Junzo Kamei1)
1)Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2)Lab. Medicinal Chem., Sch. Pharm., Kitasato Univ.
Journal of Pharmacological Sciences 121 (suppl) 65-65, 2013.

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AO1G-5-3 Implication of type 1 inositol 1, 4, 5-trisphosphate receptors (IP3Rs-1) on ethanol-induced rewarding effect in mice

Kazuhiro Kurokawa, Koji Mizuno, Seitaro Ohkuma
Dept. Pharmacol., Kawasaki Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 66-66, 2013.

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AO1G-5-4 Experimental model of neurolathyrism: role of heme oxygenase-1 in the vascular insult associated with hind-leg paraparesis

Kimino Kawaguchi1), Kuniko Kusama-Eguchi1), Fernand Lambein2)
1)Dept. Biochem. Nihon Univ. Sch. Pharm., 2)IPBO, Gent Univ.
Journal of Pharmacological Sciences 121 (suppl) 66-66, 2013.

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AO1G-5-5 Studies on drug dependence (Rept. 469): Effects of chronic treatment with zolpidem on morphine induced reward effects

Daiki Masukawa, Masahiro Shibasaki, Kazunori Ishii, Yui Yamagishi, Tomohisa Mori, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 66-66, 2013.

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AO1G-5-6 Deletion of SHATI/NAT8L increases dopamine receptors on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence

Kazuya Toriumi1),2), Mizuki Kondo1), Taku Nagai5), Akihiro Mouri1),3), Takenao Koseki1),2), Takayoshi Mamiya1),2), Atsumi Nitta6),7), Kiyofumi Yamada5),7), Toshitaka Nabeshima1),2),4),7)
1)Dept. Chem Pharmacol., Meijo Univ. Grad. Sch. Pharm. Sci., 2)Comp. Cognit. Sci. Int., Meijo Univ., 3)Div. Clin. Sci. Neuropsychopharmacol., Meijo Univ. Grad. Sch. Pharm. Sci., 4)Dept. Region. Pharm. Sci., Meijo Univ. Grad. Sch. Pharm. Sci., 5)Dept. Neuropsychopharmacol. Hosp. Pharmacy, Nagoya Univ. Grad. Sch. Med., 6)Dept. Pharm. Ther. Neuropharmacol., Univ. Toyama Grad. Sch. Med. Pharm. Sci., 7)Japanese Drug Organ. Appropriate Use Res.
Journal of Pharmacological Sciences 121 (suppl) 66-66, 2013.

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AO1H-6-1 Decreased ABCG2-mediated urate excretion from intestine is a common cause of hyperuricemia

Tappei Takada1), Kimiyoshi Ichida2), Hirotaka Matsuo3), Akiyoshi Nakayama3), Keizo Murakami1), Yoshihide Yamanashi1), Hiroshi Kasuga1), Nariyoshi Shinomiya3), Hiroshi Suzuki1)
1)Dpet. Pharmacy, Univ. Tokyo Hosp., 2)Dept. Pathophysiology, Tokyo Univ. Pharmacy and Life Sciences, 3)Dept. Integrative Physiology and Bio-Nano Medicine, Natl. Defense Med. College
Journal of Pharmacological Sciences 121 (suppl) 67-67, 2013.

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AO1H-6-2 Urate moves via paracellular route in the placenta

Ai Tsukada1),2), Toru Kimura3), Sumio Ohtsuki4), Toshiyuki Fukutomi3), Ichiro Uehara5), Shinji Tanigaki5), Mitsutoshi Iwashita5), Kimiyoshi Ichida2), Hiroyuki Sakurai3)
1)Dept. Pharm. Tokyo Metro. Ohtsuka Hosp., 2)Dep. of Pathophysiol. Tokyo Univ. of Pharm. and Life Sci., 3)Dept. Pharm. and Toxicol. Kyorin Univ. Sch. Med., 4)Dept. Pharm. Microbiol. Fac. Life Sci. Kumamoto Univ., 5)Dept. Ob. and Gyn. Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 67-67, 2013.

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AO1H-6-3 Angiotensin 2 receptor blocker, olmesartan ameliorates the urinary dysfunction in the spontaneously hypertensive rat via recovery of bladder blood flow and decreasing blood pressure

Shogo Shimizu, Motoaki Saito, Harunori Oiwa, Fumiya Ohmasa, Panagiota Tsounapi, Ryo Oikawa, Yukako Kinoshita, Keisuke Satoh, Shuhei Tomita
Div. of Molecular Pharmacol., Tottori Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 67-67, 2013.

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AO1H-6-4 p53 attenuates the progression of hereditary kidney disease, Alport syndrome

Ryosuke Fukuda, Kosuke Koyama, Tomoaki Koga, Yukari Kai, Mary Ann Suico, Kohei Omachi, Keishi Motomura, Tsuyoshi Shuto, Hirofumi Kai
Dept. Molecular Medicine., Kumamoto Univ. Sch Med.
Journal of Pharmacological Sciences 121 (suppl) 67-67, 2013.

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AO1H-6-5 Renoprotective effect of continuous erythropoietin receptor activator (C. E. R. A. ) in anti-Thy1.1 antibody-induced mesangial proliferative glomerulonephritis

Ken Aizawa, Michinori Hirata, Yoshihito Tashiro, Koichi Endo
Product Res. Dept, Chugai Pharm. Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 68-68, 2013.

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AO1H-6-6 Consideration of Robustness and Power of the Williams multiple comparison test in the evaluation of practical pharmacology

Nobuhiro Nakanishi1), Toshio Hashimoto1), Chikuma Hamada2)
1)Mitsubishi Tanabe Pharma Corporation, 2)Tokyo University of Science
Journal of Pharmacological Sciences 121 (suppl) 68-68, 2013.

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AO1F-7-1 Combination chemotherapy of Gefitinib with SN-38 induce EGFR degradation in Head and Neck squamous carcinoma

Naoki Umemura1), Kumi Nanbu1),2), Jun Shimada2), Hiroshi Sakagami1)
1)Dept. Pharmacol., Meikai Univ. Sch. Dent., 2)Dept. Oral surgery., Meikai Univ. sch. dent.
Journal of Pharmacological Sciences 121 (suppl) 68-68, 2013.

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AO1F-7-2 Zebrafish-based Quantitative and Systems Pharmacology of Tumor Angiogenesis in Novel Human Cancer XenoTransplantation Model

Junya Kuroyanagi1), Yasuhito Shimada1),2),3),4), Yuhei Zhang1), Noriko Umemoto1), Michiko Ariyoshi1), Yuhei Nishimura1),2),3),4), Toshio Tanaka1),2),3),4)
1)Dept. Pharmacol., Mie Univ. Grad. Sch., 2)Dept. Bioinfo. Mie Univ. Life Sci., 3)Mie Univ. Med. Zebra, 4)Dept. Omics, Mie Univ. Indust. Tech. Innov.
Journal of Pharmacological Sciences 121 (suppl) 68-68, 2013.

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AO1F-7-3 HSC70-targeted proteomics revealed the association of Rab1A with stress response in cancer cells

Masako Tanaka1), Masayuki Shiota1), Katsuyuki Takahashi1), Masayo Yamagata2), Tokihito Yukimura2), Hideki Wanibuchi3), Mayuko Oka1), Yasukatsu Izumi1), Katsuyuki Miura4), Hiroshi Iwao1)
1)Dept. Pharmacol., Osaka City Univ. Grad. Sch. Med., 2)Lab. Clin. Pharmacol., Fac. Pharm., Osaka Ohtani Univ., 3)Dept. Pathol., Osaka City Univ. Grad. Sch. Med., 4)Appl. Pharmacol. Ther., Osaka City Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 69-69, 2013.

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AO1F-7-4 MDR-1 and ABCG2 inhibitor, elacridar, enhances cytotoxic effects of sunitinib on RCC cell lines

Sana Siddig, Hiromi Sato, Rina Suzuki, Miaki Uzu, Sayumi Suzuki, Yuki Nomura, Koichi Ueno
Grad. Sch. of Pharmaceut Sci., Chiba Univ.
Journal of Pharmacological Sciences 121 (suppl) 69-69, 2013.

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AO1F-7-5 BORONOPHENYLALANINE, A RATIONAL CARRIER FOR 10B FOR BORON NEUTRON CAPTIVE THERAPY, IS TRANSPORTED BY BOTH LAT1 AND LAT2

Printip Wongthai, Pattama Wiriyasermkul, Yumiko Nishinaka, Ryuichi Ohgaki, Kenjiro Tadagaki, Shushi Nagamori, Yoshikatsu Kanai
Div. of Biosystem Pharmacol., Dept. of Pharmacol., Grad. Sch. of Med., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 69-69, 2013.

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AO1F-8-1 Resveratrol ameliorates skeletal muscle function in the mdx mouse, a model of Duchenne muscular dystrophy

Rio Sebori1), Atsushi Kuno1),2), Takashi Hayashi1),3), Ryusuke Hosoda1), Yusuke Hori1), Yoshiyuki Horio1)
1)Dept. Pharmacol., Sapporo Med. Univ. Sch. Med., 2)2nd. Dept. Int. Med., Sapporo Med. Univ. Sch. Med., 3)Dept. Neurol. Med., Sapporo Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 69-69, 2013.

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AO1F-8-2 Time dependent changes in activation of RhoA/ROCK and ERM in the elevation of intestinal P-gp by etoposide

Takuro Kobori, Shinichi Harada, Kazuo Nakamoto, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 70-70, 2013.

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AO1F-8-3 Roles of the prostaglandin I2-IP system in the development of nonalcoholic steatohepatitis

Shima Kumei1),2),4), Koh-ichi Yuhki1),4), Fumiaki Kojima1),4), Hitoshi Kashiwagi1),4), Toshikatsu Okumura2), Shuh Narumiya3),4), Fumitaka Ushikubi1),4)
1)Dept. Pharmacol., Asahikawa Med. Univ., 2)Dept. General med., Asahikawa Med. Univ., 3)Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med., 4)CREST, Japan Science and Technology Agency
Journal of Pharmacological Sciences 121 (suppl) 70-70, 2013.

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AO1F-8-4 A Small Peptide Inhibitor of Inflammatory Bone Resorption Promotes BMP-2-Induced Bone Formation

Masud Khan1);2), Keiichi Ohya1), Neil Alles1), Niroshani Soysa3), Al Mamun1), Kenichi Nagano1), Risako Mikami1), Yuriko Furuya4), Hisataka Yasuda4), Kazuhiro Aoki1)
1)Dept. Bio-Matrix, Grad. Sch., Tokyo Med & Dent Univ., 2)GCOE, Tokyo Med & Dent Univ., 3)Pharmacol., Fac. Dental Sci., Univ. Peradeniya, 4)Oriental Yeast Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 70-70, 2013.

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AO1F-8-5 Alteration of distribution of gastric parietal cells and cell proliferation in gastric corpus mucosal glands after chronic Helicobacter pylori infection in Mongolian gerbils

Mei Matoba1), Rika Onishi1), Akiko Kimura1), Mayu Fukuzawa1), Mika Yamamoto1), Kanako Hamaya1), Kikuko Amagase2), Toshiko Murakami2), Koji Takeuchi2), Motonobu Murakami1)
1)Faculty of Pharmaceutical Sciences, Department of Pharmacotherapy, Doshisha Women's College of Liberal Arts, 2)Kyoto Pharmaceutical University, Department of Pharmacology and Experimental Therapeutics
Journal of Pharmacological Sciences 121 (suppl) 70-70, 2013.

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AO1G-9-1 Cooperative regulation of cellular contractility by Rho-kinase/Scrib/Shroom2 complex

Tomonari Hamaguchi, Kei Kozawa, Katsuhiro Kato, Shohag MD.Hasanuzzaman, Xinjian Zhang, Tomoki Nishioka, Mutsuki Amano, Kozo Kaibuchi
Dept. Neuroscience/Mol.Pharmacol., Nagoya Univ. Grad. Scho. Med.
Journal of Pharmacological Sciences 121 (suppl) 71-71, 2013.

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AO1G-9-2 Endothelin-1-induced down-regulation of Nav1.7 expression in adrenal chromaffin cells: attenuations of catecholamine secretion and tau dephosphorylation

Takayuki Nemoto1), Toshihiko Yanagita1), Chihiro Sugita1), Akihiko Wada2), Manabu Murakami1)
1)Dept. Pharmacol., Miyazaki Univ., 2)Dept. Sports Health and Welfare, Social Welfare, Kyushu Univ. Hlth. Welfare
Journal of Pharmacological Sciences 121 (suppl) 71-71, 2013.

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AO1G-9-3 Mechanism of non-vesicular release of neuroprotective DAMPs

Hayato Matsunaga, Hiroshi Ueda
Dept. Mol. Pharmacol. & Neurosci., Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 121 (suppl) 71-71, 2013.

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AO1G-9-4 Identification of N-glycosylation sites in NOX1, a catalytic subunit of NADPH oxidase with a novel antibody raised against NOX1

Misaki Matsumoto, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 121 (suppl) 71-71, 2013.

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AO1G-9-5 Phosphorylation of respiratory complex I and II by c-Src is required for neuronal viability

Masato Ogura1), Junko Yamaki1), Miwako Homma1), Shigeki Kato2), Kenta Kobayashi3), Kazuto Kobayashi2), Yoshimi Homma1)
1)Dept. Biomol. Sci., Fukushima Med. Univ. Sch. of Med., 2)Dept. Mol. Genet., Fukushima Med. Univ. Sch. of Med., 3)Sect. Viral Vector Dev., Nat. Ins. Physi. Sci.
Journal of Pharmacological Sciences 121 (suppl) 72-72, 2013.

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AO1G-9-6 Pharmacological characterization of zebrafish Ca2+-mobilizing prostanoid receptors

Ryo Iwasaki1), Atsuo Kawahara2), Asuka Inoue3), Junken Aoki3), Soken Tsuchiya1), Yukihiko Sugimoto1)
1)Grad. Sch. Pharm. Sci., Kumamoto Univ., 2)QBiC., 3)Grad. Sch. Pharm. Sci., Tohoku Univ.
Journal of Pharmacological Sciences 121 (suppl) 72-72, 2013.

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AO1H-10-1 Bile Acid Receptor TGR5 Agonism Enhances Vascular Endothelial Barrier Function

Taiki Kida, Takahisa Murata, Masatoshi Hori, Hiroshi Ozaki
Vet. Pharmacol. The Univ. of Tokyo
Journal of Pharmacological Sciences 121 (suppl) 72-72, 2013.

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AO1H-10-2 The role of complement protein C1q in activation of Wnt signaling and in aging

Atsuhiko Naito
Dept. Cardiovasc. Regen. Med., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 72-72, 2013.

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AO1H-10-3 Role of EP4-EPRAP signaling in obesity and diabetes

Mika Yasui, Manabu Minami, Sei Higuchi, Masayuki Yokode
Depart. of Clinical Innovative Medicine, Grad. Sch. of Med., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 73-73, 2013.

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AO1H-10-4 A novel adipocytokine, omentin inhibits smooth muscle cells migration and apoptosis as well as increase in blood pressure

Kyosuke Kazama, Muneyoshi Okada, Yukio Hara, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 73-73, 2013.

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AO1H-10-5 Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure

Lei Li1), Sachio Morimoto1), Sachiko Take2), Dong-Yun Zhan3), Cheng-Kun Du3), Yuan-Yuan Wang1), Xue-Li Fan1), Tatsuya Yoshihara1), Fumi Takahashi1), Toshihiko Katafuchi2), Toshiyuki Sasaguri1)
1)Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ., 2)Dept. Integrative Physiology. Med. Sci., Kyushu Univ., 3)Natl. Cerebral & Cardiovasc. Res. Ctr. Inst.
Journal of Pharmacological Sciences 121 (suppl) 73-73, 2013.

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AO1H-10-6 Impaired blood flow recovery in Diabetes Mellitus mice by down regulation of VEGFR1TK signaling

Kazuhito Oba1),2), Hideki Amano1), Yoshiya Ito1), Koji Eshima3), Takehito Sato1), Fumihiro Ogawa1), Shinichiro Okizaki1),2), Hirotoki Ohkubo1), Chie Kurashige1), Mariko Kamata1), Masayoshi Shichiri2), Masataka Majima1)
1)Dept. Pharmacol, Kitasato Univ Sch Med, 2)Dept. Endocrinol, Diabetes, and Metabolism, Kitasato Univ Sch Med, 3)Dept. immunol, Kitasato Univ Sch Med
Journal of Pharmacological Sciences 121 (suppl) 73-73, 2013.

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AO1F-11-1 Physiological implications of TRPV1 in microglial migration and phagocytosis

Takahito Miyake, Hisashi Shirakawa, Jun Miyanohara, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 74-74, 2013.

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AO1F-11-2 Plasma Membrane Monoamine Transporter (PMAT) has Important Roles in Monoamine Clearance in Astrocyte

Fumito Naganuma, Takeo Yoshikawa, Tomomitsu Iida, Kazuhiko Yanai
Dept. Phamacol., Tohoku Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 74-74, 2013.

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AO1F-11-3 Purinergic Regulation of Astrocytic Phagocytosis

Yosuke Morizawa1), Yuri Hirayama1), Shinsuke Shibata2), Gu Ben3), Wiley James3), Hideyuki Okano2), Schuichi Koizumi1)
1)Dept. Neuropharmacol., Univ. Yamanashi, 2)Dept. Physiol, Keio University School of Medicine, 3)Florey Neuroscience Institutes, University of Melbourne
Journal of Pharmacological Sciences 121 (suppl) 74-74, 2013.

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AO1F-11-4 Effects of dopamine on superoxide dismutase in cultured astrocytes

Katsura Takano, Nobuyuki Tanaka, Kenji Kawabe, Mitsuaki Moriyama, Yoichi Nakamura
Lab. Integrative Physiology, Vet. Sci., Osaka Pref. Univ.
Journal of Pharmacological Sciences 121 (suppl) 74-74, 2013.

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AO1F-11-5 Chronic exposure to amyloid-β 1-40 exhibits the reduction in excitatory synaptic transmission by promoting aging-like features in cultured astrocytes

Hideto Okuda1), Syutaro Katsurabayashi1), Kaori Kubota1), Koutaro Takasaki1), Kenichi Mishima1), Michihiro Fujiwara1), Katsunori Iwasaki1),2)
1)Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 2)A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University
Journal of Pharmacological Sciences 121 (suppl) 75-75, 2013.

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AO1G-12-1 The significance of hippocampal histone acetylation as a common factor involved in the development of emotional resistance and adaptation to stress in mice

Kazuya Miyagawa, Minoru Tsuji, Hiroko Miyagishi, Hiroshi Takeda
Dept. Pharmacol., Sch. Pharmacol., Int. Univ. Health and Welfare
Journal of Pharmacological Sciences 121 (suppl) 75-75, 2013.

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AO1G-12-2 Enhanced response of prefrontal serotonergic system to social encounter in isolation-reared mice

Ryota Araki1), Yukio Ago1), Asuka Sasaga1), Saki Nishiyama1), Kazuhiro Takuma1), Toshio Matsuda1),2)
1)Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmacol. Sci., Osaka Univ., 2)Unit-Grad. Sch. of Child Dev., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 75-75, 2013.

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AO1G-12-3 The δ opioid receptor agonist KNT-127 produces distinct anxiolytic-like effects in rats without producing the adverse effects associated with benzodiazepines

Azusa Sugiyama1),2), Akiyoshi Saitoh1), Yuya Makino1),2), Misa Yamada1), Masatoshi Inagaki1), Jun-Ichiro Oka2), Hiroshi Nagase3), Mitsuhiko Yamada1)
1)Dept. Neuropsychopharmacol., NIMH.NCNP., 2)Lab. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. Sci., 3)Lab. of Med. Chemistry., Sch. of Pharmacy., Kitasato Univ.
Journal of Pharmacological Sciences 121 (suppl) 75-75, 2013.

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AO1G-12-4 Optogenetic control of central serotonergic neurons and anxiety-like behavior in mice

Yu Ohmura1), Kenji Tanaka2), Akihiro Yamanaka3), Mitsuhiro Yoshioka1)
1)Dept. Neuropharmacol., Hokkoido Univ. Sch. Med., 2)Dept. Neuropsych., Keio Univ. Sch. Med., 3)Dept. Neurosci. II, RIEM, Nagoya Univ.
Journal of Pharmacological Sciences 121 (suppl) 76-76, 2013.

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AO1G-12-5 Role of dopamine receptors in ES and iPS cell differentiation

Yukari Suda1), Naoko Kuzumaki1),2), Michiko Narita1), Yusuke Hamada1), Chizuru Iwasawa1), Yohei Okada2), Wado Akamatsu2), Hideyuki Okano2), Minoru Narita1)
1)Dept. Pharmacol., Hoshi Univ. Sch. Pharm., 2)Dept. Physiol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 76-76, 2013.

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AO1G-12-6 Behavioral and cortical EEG evaluations confirm the roles of both CCKA and CCKB receptors in mouse CCK-induced anxiety

Heng Li, Hidenobu Ohta, Hitomi Izumi, Masumi Inagaki
Dept. Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry
Journal of Pharmacological Sciences 121 (suppl) 76-76, 2013.

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AO1H-13-1 Effects of nitrosonifedipine on the diabetic nephropathy with the endothelial dysfunction

Noriko Yamano1), Keisuke Ishizawa2), Shoko Fujii2), Asami Nuno2), Masaki Imanishi1), Takumi Sakurada1), Yuta Suzuki2), Furi Endo2), Yuki Ishizawa1), Yoshitaka Kihira1), Yasumasa Ikeda1), Koichiro Tsuchiya2), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 2)Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 76-76, 2013.

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AO1H-13-2 Regulation of the basal activity of Cav1.2 cardiac L-type Ca2+ channel by casein kinase 2

Toshihide Kashihara, Tsutomu Nakada, Shimmon Gomi, Mitsuhiko Yamada
Dept. Mol. Pharmacol., Shinsyu Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 77-77, 2013.

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AO1H-13-3 Nicorandil improves endothelial function of femoral artery without lowering blood pressure in Dahl salt-sensitive rats

Kenichi Serizawa, Kenji Yogo, Yoshihito Tashiro, Koichi Endo
Product Res. Dept., Chugai Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 77-77, 2013.

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AO1H-13-4 Cathelicidin antimicrobial peptide inhibits fibroblasts migration via P2X7 receptor signaling

Shohei Kumagai, Hiroyuki Nakayama, Kazuki Matsui, Haruyo Kawaguchi, Akimitsu Miyawaki, Tomomi Yamashita, Yasushi Fujio
Dept. Clin. Sci. and Biomed, Grd. Sch., Pharm. Sci Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 77-77, 2013.

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AO1H-13-5 Electrophilic modification of H-Ras underlies development of chronic heart failure after myocardial infarction

Naoyuki Kitajima1), Tomohiro Sawa2), Takaaki Akaike2), Motohiro Nishida1)
1)Dept. Drug. Discov. and Evol., Grad. Sch. of Pharm. Sci., Kyushu Univ., 2)Dept. Microbiol., Grad. Sch. of Med. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 77-77, 2013.

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AO1H-13-6 TNF-α decreases matrix Gla protein gene expression in human aortic valve interstitial cells obtained from patients with calcific aortic stenosis

Anan Nomura1),2), Kazuhiko Seya1), Zaiqiang Yu1),2), Kazuyuki Daitoku2), Shigeru Motomura1), Ikuo Fukuda2), Ken-Ichi Furukawa1)
1)Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med., 2)Dep. Thorac. Cardiovasc. Surg., Hirosaki Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 78-78, 2013.

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O2E-1-1 A role for inflammation-related molecules in behavioral depression induced by repeated stress in mice

Tomoyuki Furuyashiki, Shiho Kitaoka, Kohei Tanaka, Yuta Senzai, Xiang Nie, Shuh Narumiya
Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 80-80, 2013.

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O2E-1-2 Stimulation of sigma-1 receptor by DHEA in the hippocampal dentate gyrus and anti-depressive effect

Shigeki Moriguchi, Yui Yamamoto, Yuzuru Sasaki, Kosuke Miyajima, Hideaki Tagashira, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 80-80, 2013.

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O2E-1-3 Role of calcitonin gene-related peptide (CGRP) in depression-like behavior

Yusuke Sakamoto1), Ayaka Sawada1), Hitomi Sasaki1), Hikari Hamamoto1), Yoko Otiai2), Naoya Hasikawa1), Narumi Hasikawa-hobara1)
1)Dept. Life Sci., Okayama Univ of Sci., 2)3rd Dept. Anes. ICM, Kawasaki Med, Sch
Journal of Pharmacological Sciences 121 (suppl) 80-80, 2013.

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O2E-1-4 Effect of crucumin on FG7142-induced anxiety-related behaviors in mice

Ken-ichi Tanaka1),2), Ai Sakamoto2), Satoshi Sakai2)
1)Physiol. Pharmacol., Sch. Health Social Serv., Saitama Pre. Univ., 2)Dept. Clin. Pharma., Shujitsu Univ. Sch. Pharma.
Journal of Pharmacological Sciences 121 (suppl) 80-80, 2013.

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O2E-1-5 Enhanced endocannabinoid and glutamate functions in the amygdala increase fear memory of diabetic mice

Misa Kai, Hiroko Ikeda, Megumi Ikegami, Junzo Kamei
Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 81-81, 2013.

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O2E-2-1 Effect of chronic sleep deprivation and dietary histamine on mice locomotor and anxiogenic-like behavior

Attayeb Mohsen, Takeo Yoshikawa, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 81-81, 2013.

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O2E-2-2 Postnatal chronic treatments with sodium valproate and sodium n-butyrate improve cognitive impairment in mice prenatally exposed to sodium valproate

Shunsuke Kataoka1), Kazuhiro Takuma1), Yuta Hara1), Yuko Maeda1), Erika Takano1), Yukio Ago1), Toshio Matsuda1),2)
1)Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2)Unit-Grad. Sch. of Child Dev., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 81-81, 2013.

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O2E-2-3 Effect of voluntary exercise on abnormal behaviors in PACAP-KO mice

Akira Nakagawa1), Rui Fukuyama1), Hiroshi Yamaguchi1), Norihito Shintani2), Hitoshi Hashimoto2),3), Yukio Ago1), Kazuhiro Takuma1), Toshio Matuda1),3)
1)Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2)Molecular Neuropharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 3)Unit-Grad. Sch. of Child Dev., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 81-81, 2013.

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O2E-2-4 Role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced addiction

Fumiya Shinohara, Yukari Kihara, Masabumi Minami, Katsuyuki Kaneda
Dept Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 82-82, 2013.

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O2E-2-5 Central administration of olanzapine activates gluconeogenesis through the sympathetic nervous system

Takahiro Ohashi1), Megumi Ikegami1), Hiroko Ikeda1), Atsuko Kamei2), Junzo Kamei1)
1)Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2)Mine Pharmacy
Journal of Pharmacological Sciences 121 (suppl) 82-82, 2013.

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O2E-3-1 COMPARISON OF ANALGESIC DRUGS FOR RATS WITH A SPINAL CORD INJURY PAIN

Kenji Suehiro1), Aldric Hama1), Katsuo Toide1), Hiroyuki Takamatsu1), Kazuo Umemura2)
1)Hamamatsu Pharma Research, 2)Dept. Pharmacol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 82-82, 2013.

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O2E-3-2 Involvement of spinal astrocytes and reactive oxygen species on bortezomib-induced mechanical allodynia in mice

Ryo Kitamura, Tsugunobu Andoh, Yasushi Kuraishi
Lab. of Applied Pharmacol., Graduate School of Med. and Pharm. Sci., Univ. of Toyama
Journal of Pharmacological Sciences 121 (suppl) 82-82, 2013.

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O2E-3-3 Calpain inhibitor suppresses paclitaxel-induced neuropathic pain and underlying demyelination

Ryo Yano, Kohei Araki, Lin Ma, Hiroshi Ueda
Dept. Mol. Pharmacol. & Neurosci., Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 121 (suppl) 83-83, 2013.

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O2E-3-4 Quantification of lysophosphatidic acid through glial activation in neuropathic pain using MALDI-TOF-MS analysis

Jun Nagai, Lin Ma, Hiroshi Ueda
Dept. Mol. Pharmacol. & Neurosci., Nagasaki Univ., Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 121 (suppl) 83-83, 2013.

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O2F-4-1 Mechanisms underlying cardiac diastolic dysfunction in SHRSP.Z-Leprfa / IzmDmcr (SHRSP.ZF) rats with metabolic syndrome

Satomi Kagota1), Kana Maruyama1), Yukari Tada1), Hirokazu Wakuda1), Noriko Yoshikawa2), Kazuki Nakamura2), Kazumasa Shinozuka1)
1)Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ., 2)Dept. Pharmacol. I, Sch. Pharmaceu. Sci., Mukogawa Women's Univ.
Journal of Pharmacological Sciences 121 (suppl) 83-83, 2013.

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O2F-4-2 Regulatory T cells (Tregs) ameliorate myocardial infarction (MI)-induced cardiac remodeling in mice

Shiori Taga, Tomomi Yamashita, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clin. Sci. and Biomed, Grd. Sch. Pharm. Sci. Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 83-83, 2013.

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O2F-4-3 The role of GRK5 in myocardial infarction

Mika Fujino, Michio Nakaya, Makoto Noda, Miyuki Takashima, Hitoshi Kurose
Dept. Pharmacol. and Toxicol., Kyushu Univ. Grad. Sch. of Phar.
Journal of Pharmacological Sciences 121 (suppl) 84-84, 2013.

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O2F-4-4 Regulation of mitochondrial ATP production through sigma-1 receptor in cardiomyocyte

Hideaki Tagashira, Norifumi Shioda, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ., Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 84-84, 2013.

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O2F-4-5 The myocardial activation of CaMKIIβ leads to heart failure

Komayu Wajima, Hiroyuki Nakayama, Tatsuto Hamatani, Sachi Matsunami, Shohei Kumagai, Tomomi Yamashita, Yasushi Fujio
Dept. Clin. Sci. and Biomed, Grd. Sch., Pharm. Sci. Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 84-84, 2013.

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O2F-5-1 Short-term caloric restriction mediates cardiac redox state and attenuates hypertrophy induced by pressure overload

Toshihiro Amano, Miyuki Kobara, Kazuki Noda, Akiko Furumori, Wei Tian, Hiroe Toba, Tetsuo Nakata
Dept. Clinical Pharm., Kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 121 (suppl) 84-84, 2013.

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O2F-5-2 Zebrafish-based Quantitative and Systems Pharmacology of Anticancer Therapies induced Cardiotoxicity

Noriko Umemoto1), Miko Kawabata1),5), Yuhei Nisihmura1),2),3),4), Zi Zhang1), Beibei Zhang1), Junya Kuroyanagi1), Yasuhito Shimada1),2),3),4), Toshio Tanaka1),2),3),4)
1)Dept. Pharmacol., Mie Univ. Grad. Sch. Med., 2)Mie Univ. Med. Zebra, 3)Dept. Bioinfo. Mie Univ. Life Sci., 4)Dept. Omics, Mie Univ. Indust. Tech. Innov., 5)Dept. Clin. Anesthe. Mie Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 85-85, 2013.

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O2F-5-3 Pharmacological effects of urocortins on nicotine-induced oxidative stress to HL-1 cardiomyocytes

Keiichi Ikeda1), Kouki Fujioka1), Yoshinobu Manome1), Katsuyoshi Tojo2)
1)Dept. Mol. Cell. Biol., Inst. DNA Med., Res. Cent. Med. Sci., Jikei Univ. Sch. Med., 2)Div. Diabetes Endocrinol., Dept. Intern. Med., Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 85-85, 2013.

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O2F-5-4 Anti-platelet effect of tetrahydrobiopterin on mouse whole blood

Yui Suganuma, Kazuhisa Ikemoto, Chiho Ichinose, Takahide Nomura, Kazunao Kondo
Dept. Pharmacol., Sch. Med., Fujita Health Univ.
Journal of Pharmacological Sciences 121 (suppl) 85-85, 2013.

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O2F-6-1 Therapeutic targets of coronary artery spasm and K+ channel openers

Teruyuki Yanagisawa
Dept. Mol. Pharmacol., Tohoku Grad. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 85-85, 2013.

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O2F-6-2 Domain Coupling in Inward Rectifier Potassium Channels

Atsushi Inanobe1), Atsushi Nakagawa2), Yoshihisa Kurachi1)
1)Dept. of Pharmacol., Osaka Univ., Grad. Sch. of Med., 2)Inst. for Protein Res., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 86-86, 2013.

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O2F-6-3 Molecular mechanism linking the lipid metabolism and the cardiac pacemaker activity

Hiroko Maruyama, Atsushi Sugiyama, Satomi Adachi-Akahane
Dept. Pharmacol., Toho Univ. Fac. Med.
Journal of Pharmacological Sciences 121 (suppl) 86-86, 2013.

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O2F-6-4 Effects of candesartan on electrical remodeling in hearts of inherited dilated cardiomyopathy model mice

Nagomi Kurebayashi1), Fuminori Odagiri1),2), Masami Sugihara1),2), Takeshi Suzuki1),2), Hana Inoue3), Takashi Murayama1), Takao Shioya4), Masato Konishi4), Yuji Nakazato2), Hiroyuki Daida2), Takashi Sakurai1), Sachio Morimoto5)
1)Dept Pharmacol, Juntendo Univ Sch Med, 2)Dept Cardiol, Juntendo Univ Sch Med, 3)Dept Physiol, Tokyo Med Univ, 4)Dept Physiol, Saga Univ, 5)Dept Clin Pharmacol, Grad Sch Med Sci, Kyusyu Univ
Journal of Pharmacological Sciences 121 (suppl) 86-86, 2013.

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O2G-7-1 Differential effect of intravenous anesthetics in mice deficient in phospholipase C-related but catalytically inactive protein type-1

Shinya Ueno1), Yoshikazu Nikaido1), Junko Yamada1), Keisuke Migita1), Junko Ohta1), Tetsuya Kushikata2), Kazuyoshi Hirota2), Takashi Kanematsu3), Masato Hirata4)
1)Dept. Neurophysiol, Hirosaki Univ. Grad. Sch. Med., 2)Dept. Anesthesiol, Hirosaki Univ. Grad. Sch. Med., 3)Dept. Dental Pharmacol, Hiroshima Univ. Grad. Sch. Biomed. Sciences, 4)Laboratory Mol. and Cellular Biochem, Faculty of Dental Sci. and Station for Collaborative Res., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 86-86, 2013.

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O2G-7-2 The mechanisms of nuclear translocation of CaMKIIδ3 via dopamine D2R stimulation in neurons

Norifumi Shioda, Masahiro Sawai, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 87-87, 2013.

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O2G-7-3 Time-dependent changes of CRMP2 expression in adult mouse hippocampus during LTP-like facilitation induced through activation of nAChRs

Kenji Matsuura1), Keiichi Kadoyama1), Tooru Hirota1), Masaoki Takano2), Mieko Otani2), Shogo Matsuyama1)
1)Dept. Pharmacol., Himeji Dokkyo Univ., 2)Sch. Pharmacol., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 87-87, 2013.

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O2G-7-4 Possible relationship between conditioned fear memory and mesocortical dopaminergic function in rats

Sachiko Hiraide1), Machiko Matsumoto1), Yoshiki Yanagawa1), Shin-ichi Kimura1), Kei-ichi Shimamura1), Taku Yamaguchi2),3), Mitsuhiro Yoshioka3), Hiroko Togashi1)
1)Fac. Pharm. Sci., Health Sci. Univ. of Hokkaido, 2)Dept. Pharmacol., Fac. Pharm. Sci., Nagasaki Intl. Univ., 3)Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 121 (suppl) 87-87, 2013.

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O2G-7-5 SV2A missense mutation facilitates the kindling epileptogenesis

Yukihiro Ohno1), Tomoji Mashimo2), Takahiro Okumura1), Shizuka Ishihara1), Ryo Terada1), Saki Shimizu1), Kentaro Tokudome1), Tomita Chie1), Ryosuke Kitaya1), Tomoya Tanaka1), Naofumi Kunisawa1), Masashi Sasa3), Tadao Serikawa2)
1)Lab. Pharmacol., Osaka Univ. Pharm. Sci., 2)Inst. Lab. Animals, Kyoto Univ. Sch. Med., 3)Nagisa Clinic
Journal of Pharmacological Sciences 121 (suppl) 87-87, 2013.

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O2G-8-1 Preclinical evaluation of novel 18F-labeled arylquinoline derivatives for in vivo imaging of tau pathology in Alzheimer's disease

Ryuichi Harada1), Nobuyuki Okamura1), Shozo Furumoto1),2), Tetsuro Tago2), Takeo Yoshikawa1), Hiroyuki Arai3), Ren Iwata2), Kazuhiko Yanai1), Yukitsuka Kudo4)
1)Dept. Pharmacol., Tohoku Univ. Sch. Med., 2)CYRIC, Tohoku Univ., 3)Dept. Geriatrics and Gerontologhy., Tohoku Univ. Sch. Med., 4)Clinical Research and Innovation and Education Center, Tohoku Univ. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 88-88, 2013.

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O2G-8-2 Potential use of branched-β- cyclodextrin as a novel therapeutic tool for transthyretin-related amyloidosis

Hirofumi Jono1),2), Takayuki Anno3), Keiichi Motoyama3), Yohei Misumi4), Masayoshi Tasaki4), Mitsuharu Ueda4), Satoru Shinriki5), Konen Obayashi5), Hidetoshi Arima3), Yukio Ando4)
1)Dept. Pharmacy, Kumamoto Univ. Hosp., 2)Dept. Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto Univ., 3)Dept. Physical Pharmaceutics, Graduate School of Life Sciences, Kumamoto Univ., 4)Det. Neurology, Graduate School of Life Sciences, Kumamoto Univ., 5)Diagnostic Unit for Amyloidosis, Dept. of Laboratory Medicine, Kumamoto Univ. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 88-88, 2013.

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O2G-8-3 Involvement of protein kinase CK2 in the aggresome clearance

Masahiko Watabe1),2), Toshio Nakaki1)
1)Dept. Pharmacol., Teikyo Univ. Sch. Med., 2)G-MEC, Teikyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 88-88, 2013.

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O2G-8-4 Low-grade overexpression of FUS in nucleus causes neuronal cell death

Hiroaki Suzuki, Masaaki Matsuoka
Dept. Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 88-88, 2013.

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O2G-8-5 Roles of osteopontin on the disease onset in the mouse model of amyotrophic lateral sclerosis

Mamiko Niikura1), Yasuhiro Moriwaki1), Shogo Tanabe2), Mami Tai1), Kosuke Onisi1), Koji Yamanaka3), Hidemi Misawa1)
1)Dept. Pharmacol., Keio Univ. Fac. Pharm., 2)Dept. Mol Neurosci., Osaka Univ. Grad. Sch. Med., 3)RIKEN BSI
Journal of Pharmacological Sciences 121 (suppl) 89-89, 2013.

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O2G-9-1 Influence of hepatic vagotomy on the recovery of post-ischemic glucose intolerance and neuroprotective effect induced by intra-hypothalamic orexin-A

Shinichi Harada, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 89-89, 2013.

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O2G-9-2 Tissue-type plasminogen activator modulates adrenergic nerve function after stroke

Yasuhiro Suzuki1), Nobuo Nagai2), Kazuo Umemura1)
1)Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2)Dept. Animal Biosci. Nagahama Inst, Bio-Sci. Tech.
Journal of Pharmacological Sciences 121 (suppl) 89-89, 2013.

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O2G-9-3 Direct Angiotensin II Type-2 Receptor Agonist, Compound 21, Prevents Ischemic Brain Damage with Pretreatment and Administration after Middle Cerebral Artery Occlusion

Masaki Mogi, Li-Juan Min, Jun Iwanami, Masatsugu Horiuchi
Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine
Journal of Pharmacological Sciences 121 (suppl) 89-89, 2013.

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O2G-9-4 Laser-induced selective thrombolysis without vessel damage in the rabbit ferric chloride-induced arterial thrombosis model

Yuji Matsumoto1), Kazuya Hokamura1), Daisuke Yamashita2), Yoshiyuki Shimizu2), Yoshinori Tamaoki2), Toshiyuki Kawashima2), Yutaka Yamashita2), Hiroyuki Okada2), Teiji Nakayama3), Kazuo Umemura1)
1)Dep. Pharmacol., Hamamatsu Univ. Sch. Med., 2)Cent. Res. Lab., Hamamatsu Photonics K.K., 3)Dep. Neurosurg., Hamamatsu Medical Center
Journal of Pharmacological Sciences 121 (suppl) 90-90, 2013.

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O2H-10-1 Kv7 CHANNEL ACTIVATION REDUCES SPONTANEOUS EXCITABILITY OF MOUSE ISOLATED DETRUSOR SMOOTH MUSCLE, WHILST LEAVING STIMULUS EVOKED CONTRACTION UNAFFECTED

Peter Sidaway1),2), Jessica Bowen2), Francesca Caputo3), Noriyoshi Teramoto1), Keith L.Brain2)
1)Department of Pharmacology, Faculty of Medicine, Saga University, 2)Clinical and Experimental Medicine, University of Birmingham, 3)Department of Neuroscience, University of Siena
Journal of Pharmacological Sciences 121 (suppl) 90-90, 2013.

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O2H-10-2 Electrical activity of the mouse pulmonary vein myocardium

Yayoi Tsuneoka, Yuka Kobayashi, Yoriko Honda, Masato Tsuruta, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 90-90, 2013.

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O2H-10-3 Ca2+-dependent modulation of the L-type Ca2+ channel function in cardiac E-C coupling

Satomi Adachi-Akahane, Hiroko Izumi-Nakaseko, Atsushi Sugiyama
Dept. Pharmacol., Toho Univ. Fac. Med.
Journal of Pharmacological Sciences 121 (suppl) 90-90, 2013.

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O2H-10-4 Identification and characterization of STIM1L, a novel splice variant of STIM1

Takahiro Horinouchi, Tsunehito Higashi, Koji Terada, Tsunaki Higa, Yosuke Mai, Chizuru Hatate, Prabha Nepal, Mika Horiguchi, Takuya Harada, Soichi Miwa
Dept. Cell. Pharmacol., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 91-91, 2013.

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O2H-10-5 Roles of Ca2+ release-activated Ca2+ (CRAC) channels on cell cycle progression and proliferation in bovine brain capillary endothelial cells

Hiroaki Kito1), Hisao Yamamura1), Susumu Ohya1),2), Kiyofumi Asai3), Yuji Imaizumi1)
1)Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci, Nagoya City Univ., 2)Dept. Pharmacol., Kyoto Pharm. Univ., 3)Dept. Mol. Neurobiol., Grad. Sch. Med. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 91-91, 2013.

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O2H-11-1 Renal GABA-related molecule mRNA alterations in hypertensive model rats with salt loading

Junichi Yatabe1),2), Kozue Takano1), Midori Yatabe1), Asami Abe1), Yu Suzuki1), Hironobu Sanada3), Tsuyoshi Watanabe2), Junko Kimura1)
1)Dept. Pharmacol., Fukushima Med. Univ. Sch. Med., 2)Dept. Nephrol., Hypertens., Diabetol., Endo. and Metab., Fukushima Med. Univ. Sch. Med., 3)Div. of HSR, Fukushima Welfare Federation of Agricultural Coop.
Journal of Pharmacological Sciences 121 (suppl) 91-91, 2013.

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O2H-11-2 Renal senescent cells accumulated in type 2 diabetic kidney can be removed by telmisartan but not by tempol

Daisuke Nakano1), Kento Kitada1), Hiroyuki Ohsaki2), Hirofumi Hitomi1), Hiroyuki Kobori1), Masahito Imanishi3), Akira Nishiyama1)
1)Dep. Pharmacol., Kagawa Univ., 2)Faculty. Clin. Examin., Ehime Pref. Univ. Health Sciences, 3)Div. Nephrol. Hypertens, Osaka City General Hospital
Journal of Pharmacological Sciences 121 (suppl) 91-91, 2013.

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O2H-11-3 Role of NADPH oxidase and renal sympathetic nervous system in the pathogenesis of ischemic acute kidney injury

Ryosuke Tanaka1), Maki Yazawa1), Nobuyuki Nakabayashi1), Hidenobu Tsutsui1),2), Mamoru Ohkita1), Tokihito Yukimura2), Yasuo Matsumura1)
1)Lab. Pathol. and Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci., 2)Lab. Clin. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
Journal of Pharmacological Sciences 121 (suppl) 92-92, 2013.

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O2H-11-4 The Effects of Iron chelation against Renal Fibrosis in Unilateral Ureteral Obstruction Mice Model

Iori Ozono1),2), Yasumasa Ikeda1), Soichiro Tajima1), Yuki Ishizawa-Izawa1), Yoshitaka Kihira1), Keisuke Ishizawa3), Koichiro Tsuchiya3), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 2)Tokushima Univ. Student Lab., 3)Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 92-92, 2013.

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O2H-11-5 Construction of a fluorescent uricase fusion protein for characterization of urate transporters

Makiko Nakamura1), Ayana Hosono1), Makoto Hosoyamada2), Kimiyoshi Ichida1)
1)Dept. Pathophysiol., Tokyo Univ. Pharm. Life Sci., 2)Dept. Human Physiol. Pathol., Teikyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 92-92, 2013.

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O2H-12-1 Roles of insulin-like growth factor binding protein 5 (IGFBP5) in cellular senescence

Yuki Toda1), Atsushi Kuno1),2), Rio Sebori1), Kouki Abe1), Yusuke Hori1), Ryusuke Hosoda1), Takashi Hayashi1), Yoshiyuki Horio1)
1)Dept. Pharmacol., Sapporo Med. Univ. Sch. Med., 2)2nd. Dept. Int. Med., Sapporo Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 92-92, 2013.

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O2H-12-2 Regulation of homodimerization of insulin receptor and insulin-like growth factor-1 receptor by heat shock protein 90 oligomerization

Toshihiko Yanagita, Takayuki Nemoto, Shinya Satoh, Toyoaki Maruta, Norie Yoshikawa, Chihiro Sugita, Manabu Murakami
Dept. Pharmacol., Miyazaki Med. Coll., Univ. Miyazaki
Journal of Pharmacological Sciences 121 (suppl) 93-93, 2013.

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O2H-12-3 Inhibitory mechanism of TNF-α-induced serine phosphorylation of IRS-1 mediated by AMPK activation

Tomohito Shibata, Akira Takaguri, Kazuo Ichihara, Kumi Satoh
Dept. Pharmacol., Hokkaido Pharm. Univ. Sch. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 93-93, 2013.

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O2H-12-4 Identification of Rab27a-GAP-interacting proteins and its functional analysis h pancreatic beta-cells

Mami Yamaoka, Mitsuhiro Okamoto, Masahiro Takei, Ichiro Niki, Toshihide Kimura
Dept. of Pharmacol., Oita Univ. Fac. of Med.
Journal of Pharmacological Sciences 121 (suppl) 93-93, 2013.

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O2E-13-1 P2Y1 receptor-regulated glial scar formation

Youichi Shinozaki, Schuichi Kozumi
Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi
Journal of Pharmacological Sciences 121 (suppl) 93-93, 2013.

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O2E-13-2 Calcium-dependent N-cadherin upregulation mediates reactive astrogliosis and neuroprotection after brain injury

Kazunori Kanemaru1), Jun Kubota1), Hiroshi Sekiya1), Kenzo Hirose2), Yohei Okubo1), Masamitsu Iino1)
1)Dept. Pharmacol., Grad. Sch. Med., The Univ. of Tokyo, 2)Dept. Neurobiol., Grad. Sch. Med., The Univ. of Tokyo
Journal of Pharmacological Sciences 121 (suppl) 94-94, 2013.

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O2E-13-3 Changes in the expression of glial fibrillary acidic protein in the hypothalamus in a mouse model of cancer cachexia

Yoshihiko Tasaki1),2), Masami Suzuki2), Shinsuke Shibata3), Daigo Ikegami1), Minoru Narita1), Yasuhito Uezono2)
1)Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2)Div. of Cancer Pathophysiol, NCCRI, 3)Dept. Physiol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 94-94, 2013.

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O2E-13-4 Microglia facilitate neurogenesis and oligodendrogenesis in the early postnatal subventricular zone

Yukari Shigemoto-Mogami1), Yasuo Ohno1), James E.Goldman2), Yuko Sekino1), Kaoru Sato1)
1)Lab. Neuropharmacol., Divi. Pharmacol., National Institute of Health Sciences, 2)Divi. Neuropathol., Univ. Columbia
Journal of Pharmacological Sciences 121 (suppl) 94-94, 2013.

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O2E-13-5 Potential roles of chromogranin A in cathepsin B-dependent IL-1β production by microglia in Alzheimer's disease

Zhou Wu, Hiroshi Nakanishi
Dept, Aging Sci. Pharmacol., Fac. Dent. Sci. Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 94-94, 2013.

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O2E-14-1 Protective effect of capsaicin against neuronal cell death induced by NMDA in rat retina; involvement of CGRP, endogenous opioid and substance P

Kenji Sakamoto, Tomonori Sagawa, Hiroko Ito, Aya Mizuta, Yuki Kurauchi, Asami Mori, Tsutomu Nakahara, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 95-95, 2013.

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O2E-14-2 Thrapeutic effect of Mirtazapine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model for Parkinson's disease

Jiro Kasahara, Naoto Kadoguchi, Shinji Okabe, Yukio Yamamura, Hironori Yokoyama
Dept. Neurobiol. Therapeu., Grad. Sch. Pharmaceu. Sci., Inst. Health Biosci., Univ. Tokushima
Journal of Pharmacological Sciences 121 (suppl) 95-95, 2013.

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O2E-14-3 Nobiletin improves cognitive impairment in Parkinson model mice

Kohji Fukunaga1), Yasushi Yabuki1), Yasushi Ooizumi2),3)
1)Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Scis., 2)Pharm. Sci. Univ. Shizuoka, 3)Grad. Sch. Engineer. Tohoku Univ.
Journal of Pharmacological Sciences 121 (suppl) 95-95, 2013.

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O2E-14-4 Nitric oxide increases activity of Parkin via S-nitrosylation

Kentaro Ozawa1), Akira Komatsubara1),2), Hiroto Kawafune1),2), Jing Zhao1), Yoji Kyotani1), Satoyasu Ito1), Kosuke Nagayama1), Yuichi Tsuji1), Yoshizumi Masanori1)
1)Dept. Pharmacol., Nara Univ. Sch. Med., 2)Dept. Pharm., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 95-95, 2013.

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O2F-15-1 C1q-induced Wnt signaling activation in hypertension-induced arterial remodeling

Atsuhiko Naito
Dept. Cardiovasc. Regen. Med., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 96-96, 2013.

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O2F-15-2 CD4+CD25+ regulatory T cells (Treg cells) migrate into hearts in experimental autoimmune myocarditis(EAM)

Rie Torii, Tomomi Yamashita, Chika Furutani, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clin. Sci. and Biomed., Grd. Sch. Pharm. Sci. Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 96-96, 2013.

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O2F-15-3 Autophagy removes superoxide-producing mitochondria and attenuates apoptosis induced by angiotensin II in cardiac myocytes

Takuro Ishigami, Miyuki Kobara, Shota Tsujimoto, Hiromi Nagai, Mai Ohdoshi, Wei Tian, Kazuki Noda, Hiroe Toba, Tetsuo Nakata
Dept. Clinical Pharm., Kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 121 (suppl) 96-96, 2013.

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O2F-15-4 Comparison of the effects of clinically available vasodilators on the spasm model of human internal thoracic artery

Yuji Nakamura1), Ken Kitahara1), Satoshi Nagasaka1), Xin Cao1), Shoji Fukuda2), Koso Egi3), Satomi Adachi-Akahane1), Atsushi Sugiyama1)
1)Dept. Pharmacol., Faculty of Med., Toho Univ., 2)Dept. Cardiovasc. Surg., National Center for Global Health and Medicine, 3)Dept. Cardiovasc. Surg., Social Insurance Chuo General Hospital
Journal of Pharmacological Sciences 121 (suppl) 96-96, 2013.

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O2F-15-5 β-arrestin2 in infiltrated macrophages plays an inhibitory role for inflammation after myocardial infarction

Kenji Watari1), Michio Nakaya1), Motohiro Nishida2), Hitoshi Kurose1)
1)Dept. Pharmacol and Toxicol, Kyushu Univ. Grad. Sch. Phar., 2)Dept. Drug Discov and Evol, Kyushu Univ. Grad. Sch. Phar.
Journal of Pharmacological Sciences 121 (suppl) 97-97, 2013.

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O2F-16-1 β1-adrenergic receptor is recycling via recycling endosome by the binding with sorting nexin27

Takatoshi Nakagawa, Michio Asahi
Dept. of Pharmacol., Faculty of Medicine, Osaka medical college
Journal of Pharmacological Sciences 121 (suppl) 97-97, 2013.

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O2F-16-2 Internalization of KCNQ1 channel by activation of the α1A and α1B adrenergic receptor

Kazuya Kurakami, Ikuo Norota, Minghua Wu, Yutaro Obara, Kuniaki Ishii
Dept. Pharmacol., Yamagata Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 97-97, 2013.

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O2F-16-3 Development of a novel tool for analysis of PKA and CaMKII activities in caveolae microdomain

Sachi Matsunami, Nao Hayamizu, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clin. Sci. and Biomed., Grd. Sch. Pharm. Sci., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 97-97, 2013.

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O2F-16-4 The third extracellular loop of (ECL3) the human calcitonin receptor-like receptor (CLR) is crucial for activation of the two adrenomedullin (AM) receptors but not the CGRP receptor

Kenji Kuwasako1), Kazuo Kitamura2), Sayaka Nagata2), Johji Kato1)
1)Frontier Sci. Res. Center, Univ. of Miyazaki, 2)Div. of Circul. and Body Fluid Reg., Faculty of Med., Univ. of Miyazaki
Journal of Pharmacological Sciences 121 (suppl) 98-98, 2013.

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O2F-16-5 Ubiquitination plays an important role in endothelin type B receptor trafficking

Koji Terada, Takahiro Horinouchi, Tsunehito Higashi, Chizuru Hatate, Soichi Miwa
Dept. Cell. Pharmacol. Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 98-98, 2013.

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O2G-17-1 Glucose-induced excitation of GLP-1 releasing neurons

Kazunari Hisadome, Noriyoshi Teramoto
Dept. Pharmacol., Saga Univ.
Journal of Pharmacological Sciences 121 (suppl) 98-98, 2013.

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O2G-17-2 Regulation of cellular proliferation by OCTN1/SLC22A4 expressed in murine neural stem cells

Noritaka Nakamichi, Takahiro Ishimoto, Hiroshi Hosotani, Tomoko Sugiura, Yukio Kato
Fac. Pharm., Kanazawa Univ.
Journal of Pharmacological Sciences 121 (suppl) 98-98, 2013.

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O2G-17-3 Co-expression of α5 integrin and fibronectin for their interaction on olfactory neuroblast migration/differentiation

Shin-ichi Murase, Hiroshi Higuchi
Dept. Pharmacol., Niigata Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 99-99, 2013.

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O2G-17-4 Action potential trains enhance spontaneous miniature hyperpolarizations in neonatal ventral tegmental area dopamine neurons

Susumu Koyama, Mark Brodie, Sarah Appel
Dep. Physiol. & Biophys., Coll. Med., Univ. Illinois Chicago
Journal of Pharmacological Sciences 121 (suppl) 99-99, 2013.

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O2G-17-5 Spontaneous electrical activity and hyperpolarization activating cation channel in rat pinealocyetes

Keiko Kiyota1), Makoto Muramatsu1), Hisao Yamamura1), Susumu Ohya2), Yuji Imaizumi1)
1)Dept Mol & Cell Pharmacol, Grad Sch Pharmaceut Sci, Nagoya City Univ., 2)Dept of Pharmacol, Kyoto Pharmaceut Univ.
Journal of Pharmacological Sciences 121 (suppl) 99-99, 2013.

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O2G-18-1 Cytoprotective effect of Hydrogen sulfide in neuronal cell; Augmentation of glutathione production and suppression of oxidative stress in mitochondria

Yuka Kimura1), Yu-ichi Goto2), Hideo Kimura1)
1)Dept. Mol. Pharm., Natl. Inst. Neurosci., Tokyo, NCNP, 2)Dept. Mental Retard. & Birth Defect, Natl. Inst. Neurosci.,Tokyo NCNP
Journal of Pharmacological Sciences 121 (suppl) 99-99, 2013.

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O2G-18-2 Production of H2S and its protection of retinal neurons from light-induced degeneration

Hideo Kimura1), Yoshinori Mikami1),2), Norihiro Shibuya1), Yuka Kimura1), Yuki Ogasawara3), Noriyuki Nagahara4), Masahiro Yamada5)
1)Dept. Mol. Pharm. Nat. Inst. Neurosci. NCNP, 2)Dept. Pharm. Faculty of Med. Tokyo Univ., 3)Meiji Pharmasceu. Univ., 4)Nippon Medical College, 5)Riken
Journal of Pharmacological Sciences 121 (suppl) 100-100, 2013.

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O2G-18-3 Desensitization of GABAB receptor may not be involved in the process of receptor internalization because of disassociation of β-arrestins

Yuka Sudo1), Minoru Hojo2), Hiroaki Murata2), Akinobu Yokoyama1),3), Kanako Miyano1), Masami Suzuki1), Seiji Shiraishi1), Yoshikazu Higami3), Yasuhito Uezono1)
1)Div. Cancer Pathophysiol., NCCRI, 2)Dept. Anesth., Nagasaki Univ. Grad Sch. Med. Sci., 3)Dept. Mol. Pathol. Metab. Dis., Faculty of Pharmaceut. Sci., Tokyo Univ. Sci.
Journal of Pharmacological Sciences 121 (suppl) 100-100, 2013.

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O2G-18-4 Regulation of Intracellular Calcium Store by a Phosphotyrosine Adaptor ShcB in Cerebellar Purkinje Cells

Sho Kakizawa1),3), Yasushi Kishimoto2), Shinichiro Yamamoto1), Kazuko Onga3), Kunihiko Yasuda3), Ryuichi Sakai4), Hiroshi Takeshima1), Nozomu Mori3)
1)Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ., 2)Dept. Biophysics, Kagawa Sch. Pharmaceu. Sci., Tokushima Bunri Univ., 3)Dept. Anat., Grad. Sch. Biomed. Sci., Nagasaki Univ., 4)Div. Metastasis Signal., Natl. Cancer Center Res. Inst.
Journal of Pharmacological Sciences 121 (suppl) 100-100, 2013.

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O2G-18-5 Accumbal dopaminergic stimulation decreases dopamine efflux in the dorsal striatum via a feed-forward striato-nigro-striatal circuitry

Hiroko Ikeda1),2), Tadashi Saigusa2), Junzo Kamei1), Noriaki Koshikawa2), Cools Alexander R.3)
1)Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2)Dept. Pharmacol. Nihon Univ. Sch. Dent., 3)Radboud Univ. Nijmegen
Journal of Pharmacological Sciences 121 (suppl) 100-100, 2013.

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O2H-19-1 Involvement of PIP5-kinase α in pressure overload-induced hypertrophy

Satomi Kita1), Ichiro Horie1), Hiroshi Hasegawa2), Yasunori Kanaho2), Takahiro Iwamoto1)
1)Dept. Pharmacol., Facul. Med., Fukuoka Univ., 2)Dept. Physiol. Chem., Grad. Sch. Comprehensive Human Sci. and Inst. Basic Med. Sci., Univ. Tsukuba
Journal of Pharmacological Sciences 121 (suppl) 101-101, 2013.

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O2H-19-2 Role of PGE2 in regulating vascular permeability

Keisuke Omori, Taiki Kida, Takahisa Murata, Masatoshi Hori, Hiroshi Ozaki
Vet. Pharmacol. Tokyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 101-101, 2013.

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O2H-19-3 Enhanced Ca2+-sensing receptor function in idiopathic pulmonary arterial hypertension

Aya Yamamura1),2), Hisao Yamamura2),3), Qiang Guo2), Adriana.M.Zimnicka2), Yasuko Kozaki1), Kikuo Tsukamoto1), Jason.X.-J.Yuan2)
1)Col. Pharm. Kinjo Gakuin Univ., 2)Dept. Med., Univ. Illinois at Chicago, 3)Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 101-101, 2013.

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O2H-19-4 Cardiohemodynamic and Electrophysiological Effects of Oseltamivir

Ken Kitahara1),2), Yuji Nakamura1), Yayoi Tsuneoka3), Satomi Adachi-Akahane1), Hikaru Tanaka3), Hiroshi Yamazaki4), Akira Takahara3),5), Junichi Yamazaki2), Takanori Ikeda2), Atsushi Sugiyama1)
1)Dept. Pharmacol., Faculty of Med., Toho Univ., 2)Div. of Cardiovasc. Med., Dept. of Internal Med., Toho Univ. Faculty of Med., 3)Dept. of Pharmacol., Faculty of Pharmaceutical Sciences, Toho Univ., 4)Lab. of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical Univ., 5)Dept. of Pharmacol. and Therapeutics, Faculty of Pharmaceutical Sciences, Toho Univ.
Journal of Pharmacological Sciences 121 (suppl) 101-101, 2013.

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O2H-19-5 Comparison of electropharmacological effects of dronedarone with those of amiodarone

Yoshiyuki Motokawa1), Yuji Nakamura1), Xin Cao1), Hiroshi Ohara1), Yukiko Yamazaki1), Ken Kitahara1), Takuma Harada1), Yukihiro Yagi1), Satomi Adachi-Akahane1), Hiroshi Yamazaki2), Atsushi Sugiyama1)
1)Dept. Pharmacol., Faculty of Med., Toho Univ., 2)Lab. Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical Univ.
Journal of Pharmacological Sciences 121 (suppl) 102-102, 2013.

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O2H-20-1 SOC channels regulate histamine-induced Ca2+ influx in human chondrocytes

Munenori Inayama1), Yoshiaki Suzuki1), Hisao Yamamura1), Susumu Ohya2), Yuji Imaizumi1)
1)Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2)Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 102-102, 2013.

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O2H-20-2 The generation of monoclonal antibodies against calcium-release activated calcium channel 1 expressed in proteoliposomes

Shuang Liu1), Erika Takemasa1), Keizou Oka2), Yuki Tanaka2), Hitoshi Hasegawa4), Hiroyuki Takeda3), Tatsuya Sawazaki3), Kazutaka Maeyama1)
1)Dept. Pharmacol. Infomational Biomed. Ehime Univ. Sch. Med., 2)Integrated Center of Sciences, Ehime Univ., 3)Cell-free Sciences and Technology Research Center and Venture Business Lab., 4)Dept. Internal Med. I. Ehime Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 102-102, 2013.

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O2H-20-3 Electropharmacological profile of amitriptyline

Hiroshi Ohara1),2), Yuji Nakamura1), Xin Cao1), Yukiko Yamazaki1),2), Yoshiyuki Motokawa1), Naoya Ueda1), Ken Kitahara1),2), Satomi Adachi-Akahane1), Junichi Yamazaki2), Takanori Ikeda2), Atsushi Sugiyama1)
1)Dept. Pharmacol., Faculty of Med., Toho Univ., 2)Div. of Cardiovasc. Med., Dept. of Internal Med., Toho Univ. Faculty of Med.
Journal of Pharmacological Sciences 121 (suppl) 102-102, 2013.

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O2H-20-4 Involvement of TRPC6 channel in fibrogenic stenosis in human intestinal myofibroblast

Rin Kurahara, Miho Sumiyoshi, Ryuji Inoue
Dept Physiol., Fukuoka Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 103-103, 2013.

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O3D-21-1 Relationship among P13-K p85 monomer, IRS-2-p85 complex and insulin-induced relaxation in spontaneously type 2 diabetic rat aorta

Shingo Nemoto, Takayuki Matsumoto, Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 121 (suppl) 103-103, 2013.

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O3D-21-2 Bovine lactoferrin stimulated angiogenesis in response to ischemic hindlimb via Src-Akt-eNOS-dependent manner

Yasumasa Ikeda1), Soichiro Tajima1), Yuki Ishizawa-Izawa1), Yoshitaka Kihira1), Keisuke Ishizawa2), Koichiro Tsuchiya2), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 2)Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 103-103, 2013.

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O3D-21-3 Roles of RAMP1 signaling in facilitation of wound healing and anglogenesis

Chie Kurashige, Kanako Hosono, Hiromi Matsuda, Masataka Majima
Dept. Pharmacol., Kitasato Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 103-103, 2013.

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O3D-21-4 Plasminogen Activator Inhibitor 1 Deficiency Reduces The Progression Of Atherosclerosis In The Murine Model Of Human Familial Hypercholesterolemia

Takayuki Iwaki, Kazuo Umemura
Department of Pharmacology, Hamamatsu University School of Medicine
Journal of Pharmacological Sciences 121 (suppl) 104-104, 2013.

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O3D-21-5 G protein-coupled receptor kinase 2 impairs insulin-induced Akt/eNOS signaling

Kumiko Taguchi1), Takayuki Matsumoto2), Tsuneo Kobayashi2), Yuichi Hattori1)
1)Dept. of Mol. Pharmacol., Graduate. Sch. Med. Pharm. Sci., Univ. of Toyama, 2)Dept. of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi Univ.
Journal of Pharmacological Sciences 121 (suppl) 104-104, 2013.

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O3D-22-1 Analysis for a lack of oral tolerance for food allergy

Hirotaka Yamashita1), Takahiro Kuromaru1), Hiroyuki Tanaka1), Hiroichi Nagai1),2), Naoki Inagaki1)
1)Lab. Pharmacol., Dept. Bioactive Mol., Gifu Pharm. Univ., 2)Gifu Jr. College Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 104-104, 2013.

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O3D-22-2 GRK6 mediates the engulfment of apoptotic cells

Akiko Hashimoto, Michio Nakaya, Mitsuru Tajima, Mina Ohba, Hiroaki Nishihara, Hitoshi Kurose
Dept. Pharmacol. and Toxicol., Kyushu Univ., Grad. Sch. of Phar.
Journal of Pharmacological Sciences 121 (suppl) 104-104, 2013.

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O3D-22-3 Role of leukotriene B4 receptor 1 (BLT1) in liver injury and repair following hepatic ischemia/reperfusion (IR) injury in mice

Hirotoki Ohkubo1),2), Yoshiya Ito2), Kanako Hosono1), Masataka Majima1)
1)Dept. Pharmacol., Kitasato Univ. Sch. Med., 2)Dept. Surgery. Kitasato Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 105-105, 2013.

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O3D-22-4 The adjuvant effect of compound 48/80 on production of IgE and IgG by intranasal administration of ovalbumin in mice

Nobuaki Matsui, Daisuke Ito, Yukari Takabatake, Eri Nashioka, Masato Kanagawa, Shingo Tada, Nobuyuki Fukuishi, Masaaki Akagi
Dept. Pharmacol., Fac. Pharm. Sci., Tokushima Bunri Univ.
Journal of Pharmacological Sciences 121 (suppl) 105-105, 2013.

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O3D-22-5 Consideration about a new mouse model of sepsis

Yusuke Naito1),2), Kento Yoshioka1), Kensuke Tanaka1),2), Hirofumi Matsunaga3), Katsumasa Nagano4), Junji Ishida4), Akiyoshi Fukamizu4), Sadao Kimura1), Koichiro Tatsumi2), Yoshitoshi Kasuya1)
1)Dept. Biochem. and Mol. Pharmacol., Chiba Univ. Med., 2)Dept. Respirol., Chiba Univ. Med., 3)Ube Industries Ltd., 4)Life Sci center of TARA, Tsukuba Univ.
Journal of Pharmacological Sciences 121 (suppl) 105-105, 2013.

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O3D-23-1 Possible role of epigenetic modifications in the pathology of sepsis

Mariko Takebe1),2), Hirofumi Oishi2), Aoki Yuta2), Michinori Takashina1), Kengo Tomita1), Kumiko Taguchi1), Hiroki Yokoo1), Mitsuaki Yamazaki2), Yuichi Hattori1)
1)Dept. of Mol. Med. Pharmacol. Gradu. Sch. Med. Pharmaceu. Sci., Univ. of Toyama, 2)Dept. of Anesth. Gradu. Sch. Med. Pharmaceu. Sci., Univ. of Toyama
Journal of Pharmacological Sciences 121 (suppl) 105-105, 2013.

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O3D-23-2 Marked increase in the expression of thymic stromal lymphopoietin in the skin of atopic dermatitis mouse model by n-6 polyunsaturated fatty acid deficiency

Masanori Fujii, Takahiro Toda, Yuki Shimazaki, Susumu Ohya, Takeshi Nabe
Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 106-106, 2013.

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O3D-23-3 Roles of Kupffer cells for insulin Sensitivity in liver

Hidetaka Morinaga, Noriyoshi Teramoto
Dept. Pharmacol., Saga Univ. Facul. Med.
Journal of Pharmacological Sciences 121 (suppl) 106-106, 2013.

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O3D-23-4 Degranulation of mast cells induced by halogenated dinitrobenzene

Satoshi Tanaka1), Yohei Manabe1), Aya Kakinoki1), Satoshi Hokari1), Marie Yoshimura1), Hiroyuki Miyachi2)
1)Dept. Immunobiol., Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci., 2)Dept. Med. Bioorg. Chem., Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 106-106, 2013.

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O3E-24-1 Sigma-1 receptor promotes neurite outgrowth via phosphorytation of TrkB

Yuriko Kimura, Yuki Fujita, Toshihide Yamashita
Dep. Mol. Neurosci., Osaka Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 106-106, 2013.

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O3E-24-2 RGMa expressed on Th17 induces neuronal cell death

Tanabe Shogo, Hiroshi Ishii, Toshihide Yamashita
Dept. Mol. Neurosci., Grad. Sch. of Med., Osaka Univ., JST-CREST
Journal of Pharmacological Sciences 121 (suppl) 107-107, 2013.

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O3E-24-3 Inorganic pyrophosphatase 1 is involved in neurite growth as a protein phosphatase

Atsushi Sanbe1),2), Yu Tezuka1), Mizuki Okada1), Yuka Tada1), Junji Yamauchi2), Hideo Nishigori1)
1)Dept. Pharmacotherapeutics., Iwate Medical Univ. Sch. Pharm., 2)Dept. Pharmacol. NCCHD. Japan
Journal of Pharmacological Sciences 121 (suppl) 107-107, 2013.

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O3E-24-4 A Caspr4/LNX2 signaling pathway promotes neurogenesis

Toshitaka Futagawa1),2), Shogo Masuda1), Katsushi Yamada3), Ryuji Ikeda1),2), Yasuo Takeda1),2)
1)Dept. Clin. Pharm. and Pharmacol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 2)Dept. Clin. Pharm., Kagoshima Univ. Hosp., 3)Dept. Clin. Pharmacol., Faculty of Pharmaceutical Sci., Nagasaki Int. Univ.
Journal of Pharmacological Sciences 121 (suppl) 107-107, 2013.

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O3E-24-5 Mass spectrometric monitoring of prostanoids in rat hypothalamic PVN microdialyates

Masahiko Tachi1), Fumio Kondo1), Minoru Fukayama2), Kazuhiro Yoshikawa2), Shoshiro Okada1)
1)Dept. Pharmacol., Aichi Med. Univ. Grad. Sch. Med., 2)Dept. Cent. Res. Lab., Aichi. Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 107-107, 2013.

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O3E-25-1 COMPARATIVE EFFICACY OF CLINCALLY USED ANALGESIC DRUGS ON NEUROPATHIC HYPERSENSITIVITY IN RATS WITH A SPINAL NERVE LIGATION

Aldric Hama1), Hiroshi Yamashita1), Kenji Suehiro1), Katsuo Toide1), Hiroyuki Takamatsu1), Kazuo Umemura2)
1)Hamamatsu Pharma Research, Inc., 2)Department of Pharmacology, Hamamatsu University School of Medicine
Journal of Pharmacological Sciences 121 (suppl) 108-108, 2013.

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O3E-25-2 The IRF8-IRF5 transcription factor axis drives P2X4Rhi reactive microglia gating neuropathic pain

Takahiro Masuda1), Makoto Tsuda1), Ryohei Yoshinaga1), Shosuke Iwamoto1), Akira Nishiyama2), Nao Nishimoto1), Hidetoshi Tozaki-Saitoh1), Tomohiko Tamura2), Kazuhide Inoue1)
1)Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2)Dept. Immunol., Grad. Sch. Med., Yokohama City Univ.
Journal of Pharmacological Sciences 121 (suppl) 108-108, 2013.

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O3E-25-3 Ceramide and its metabolite act as enhancer of pain transmission through spinal glial cells

Yuka Kobayashi, Norikazu Kiguchi, Shiroh Kishioka
Dept. Pharmacol., Wakayama Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 108-108, 2013.

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O3E-25-4 Tumor-induced nerve damage on the parietal peritoneum in a pain model of peritoneal carcinomatosis

Masami Suzuki1), Minoru Narita2), Shinsuke Shibata3), Miki Inoue1),2), Yoshihiko Tasaki1),2), Motohiro Matoba4), Yasuhito Uezono1)
1)Div. Cancer Pathophysiol., NCCRI, 2)Dept. Pharmacol., Hoshi Univ., 3)Dept. Physiol, Keio Univ., 4)Dept. Palliative Med., NCCH
Journal of Pharmacological Sciences 121 (suppl) 108-108, 2013.

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O3E-25-5 Epigenetic transcriptional activation of chemokines in astrocytes is critical for neuropathic pain

Daigo Ikegami1), Satoshi Imai1), Michiko Narita1), Akira Yamashita1), Naoko Kuzumaki2), Hideyuki Takeshima3), Hideyuki Okano3), Toshikazu Ushijima3), Minoru Narita1)
1)Dept. of Pharmacol., Hoshi Univ. Sch. of Pharm. and Pharmaceut. Sci., 2)Dept. Physiol., Keio Univ. Sch. Med., 3)Div. of Epigenomics, NCCRI
Journal of Pharmacological Sciences 121 (suppl) 109-109, 2013.

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O3E-26-1 TRPM2-mediated induction of iNOS in microglia/macrophage is involved in the progression of cerebral ischemic in mice

Shinya Sakimoto, Hisashi Shirakawa, Masaya Munakata, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sci. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 109-109, 2013.

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O3E-26-2 Rescue of cerebrovascular units by oral L-Citrulline administration in mouse brain ischemia

Miyuki Shigano1), Yasushi Yabuki1), Norifumi Shioda1), Kota Kumagai2), Masahiko Morita2), Kohji Fukunaga1)
1)Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci., 2)KYOWA HAKKO BIO CO., LTD.
Journal of Pharmacological Sciences 121 (suppl) 109-109, 2013.

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O3E-26-3 Intervation with L-arginine promotes angiogenesis and neuroblast proliferation with stroke recovery

Atsuko Niwa1), Yasumitsu Akahoshi2), Keyue Liu3), Masahiro Nishibori3), Hideo Takahashi1)
1)Dept. Pharmacol., Kinki Univ. Facul. Med., 2)Life Sci. Res. Inst., Kinki Univ., 3)Dept. Pharmacol., Okayama Univ., Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 109-109, 2013.

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O3E-26-4 Heptamethoxyflavone, a citrus flavonoid, enhances brain-derived neurotrophic factor production and neurogenesis in the hippocampus following cerebral global ischemia in mice

Satoshi Okuyama1), Naoko Shimada1), Yoshiaki Amakura2), Morio Yoshimura2), Mitsunari Nakajima1), Yoshiko Furukawa1)
1)Lab Pharmacol., Matsuyama Univ., Coll. Pharmaceutical Sci., 2)Lab Pharmacognosy, Matsuyama Univ., Coll. Pharmaceutical Sci.
Journal of Pharmacological Sciences 121 (suppl) 110-110, 2013.

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O3E-26-5 Expression of P2X7 receptor in activated astrocytes is involved in brain ischemic tolerance

Yuri Hirayama1), Yuri Ikeda-Matsuo2), Schuichi Koizumi1)
1)Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi, 2)Dept. Pharmacol., Sch. Pharm. Sci., Univ. Kitasato
Journal of Pharmacological Sciences 121 (suppl) 110-110, 2013.

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O3F-27-1 Involvement of medullary substance P in cisplatin-induced emesis in rats

Kouichi Yamamoto, Ayana Tasaka, Seikou Kim, Atsushi Yamatodani
Dept. Med. Sci. Tech., Div. Health Sci, Grad. Sch. Med. Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 110-110, 2013.

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O3F-27-2 Involvement of lysosome in degradation of AGE-cholesterol-aggregated protein in mesangial cells

Tadashi Nagamatsu1),2), Takahiro Toda1), Mari Kimura1), Yasushi Hirasawa1),2)
1)Lab. Pharmacobiol and Therapeutics, Meijo Univ. Sch. Pharm., 2)Nihon Bioresearch Inc
Journal of Pharmacological Sciences 121 (suppl) 110-110, 2013.

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O3F-27-3 Expression of GABA-related molecules in rat kidney

Kazue Takano1), Junichi Yatabe1),2), Midori Yatabe1), Asami Abe1), Yu Suzuki1), Tsuyoshi Watanabe2), Junko Kimura1)
1)Dept. Pharmacol., Fukushima Med. Univ. Sch. Med., 2)Dept. Nephrol., Hypertens., Diabetol., Endo. and Metabo., Fukushima Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 111-111, 2013.

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O3F-27-4 Renal iron accumulation in type 1 diabetic mice is independent of cell senescence

Daisuke Nakano, Tatsuyori Morita, Kento Kitada, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama
Dep. Pharmacol., Kagawa Univ.
Journal of Pharmacological Sciences 121 (suppl) 111-111, 2013.

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O3F-27-5 Urinary angiotensinogen as a predictive marker of renoprotective effect of olmesartan in patients with metabolic syndrome

Hirofumi Hitomi1), Hiroyuki Kobori1), Fumihiro Tomoda2), Satoshi Morimoto3), Toshiki Fukui4), Koichi Hasegawa5), Tsukasa Nakamura6), Daisuke Nakano1), Masakazu Kohno7), Akira Nishiyama1)
1)Dept. Pharmacol., Kagawa Univ., 2)Intern. Med 2, Univ. of Toyama, 3)Dept. Med., Tokyo Women's Med. Univ., 4)NTT West Takamatsu Hosp., 5)Hasegawa Hosp., 6)Shinmatsudo Central General Hosp., 7)Intern. Med., Kagawa Univ.
Journal of Pharmacological Sciences 121 (suppl) 111-111, 2013.

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O3F-28-1 The key phosphorylation signaling in type II alveolar epithelial cells under the development of pulmonary fibrosis

Takeshi Kobayashi1),2), Hiroyuki Amano1),2), Kensuke Tanaka1),2), Kento Yoshioka1), Sadao Kimura1), Koichiro Tatsumi2), Yoshitoshi Kasuya1)
1)Dept. Biochemistry, and Molecular Pharmacol., Chiba Univ. Sch. Med., 2)Dept. Respirol., Chiba Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 111-111, 2013.

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O3F-28-2 Membrane hyperpolarization due to ATP-sensitive K+channel openers facilitated ciliary beating in mouse airway ciliated cells

Teruya Ohba1), Eiji Sawada1), Yoshiaki Suzuki1), Hisao Yamamura1), Susumu Ohya2), Yuji Imaizumi1)
1)Dept. Mol. Cell. Phamacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2)Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University
Journal of Pharmacological Sciences 121 (suppl) 112-112, 2013.

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O3F-28-3 Serine proteases inhibitors improve the mucus hypersecretory and emphysema-like phenotypes in airway-specific βENaC-transgenic mice

Tsuyoshi Shuto, Chizuru Matsumoto, Yuki Sakaguchi, Shunsuke Kamei, Tomomi Ono, Mary Ann Suico, Hirofumi Kai
Dept. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 112-112, 2013.

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O3F-28-4 Modulations of cough reflex sensitivity through airway NMDA receptor

Yuki Nakanishi, Megumi Ikegami, Hiroko Ikeda, Junzo Kamei
Dept. Pathophysiol. Ther. Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 112-112, 2013.

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O3F-29-1 Interferon-related developmental regulator-1 activates osteoclastogenesis through modulating NF-κB pathway

Takashi Iezaki, Eiichi Hinoi, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech.
Journal of Pharmacological Sciences 121 (suppl) 112-112, 2013.

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O3F-29-2 Sphingosine-1-phosphate induces osteoblast differentiation through the Wnt/β-catenin signaling pathway

Etsuko Matsuzaki1), Yoko Hashimoto1), Katsumasa Higashi1), Fumi Takahashi-Yanaga2), Takafumi Hamachi1), Katsumasa Maeda1)
1)Dept. Periodontol. Kyushu Univ. Sch. Dent., 2)Dept. Med. Edu., Kyushu Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 113-113, 2013.

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O3F-29-3 NFAT activity-based screening for identifying osteoclastogenesis-related small compounds

Akiko Mizuta1),2), Makio Saeki1), Yuuya Kamano1),3), Kenji Takada2), Yoshinori Kamisaki1)
1)Dept. Pharmacol., Osaka Univ. Sch. Dent, 2)Dept. Orthod., Osaka Univ. Sch. Dent,, 3)Dept. Fixed Prosthod., Osaka Univ. Sch. Dent,
Journal of Pharmacological Sciences 121 (suppl) 113-113, 2013.

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O3F-29-4 A novel splice variant of BKα subunit from a human chondrosarcoma cell line OUMS-27

Yoshiaki Suzuki1), Susumu Ohya2), Hisao Yamamura1), Yuji Imaizumi1)
1)Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceu. Sci., Nagoya City Univ., 2)Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 113-113, 2013.

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O3G-30-1 Effect of Traditional Japanese Medicine Keishikashakuyakuto on visceral hyperalgesia in three kinds of irritable bowel syndrome-like model of rats

Kenjiro Matsumoto, Tomoko Yamamura, Rikako Suzuki, Kimihito Tashima, Syunji Horie
Dept. Pharmacol., Josai Int. Univ.
Journal of Pharmacological Sciences 121 (suppl) 113-113, 2013.

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O3G-30-2 Effects of Streptococcus faecalis 129 BIO 3B on abdominal pain in a rat model

Masaki Shimakawa1), Satoru Tsunemine1), Yutaka Makizaki2), Tohru Komada2), Hiroshi Ohno1), Hideki Yamamura1)
1)Biofermin Kobe Research Institute, Biofermin Pharmaceutical Co., Ltd., 2)Discovery Service, Charles River Lab. Japan
Journal of Pharmacological Sciences 121 (suppl) 114-114, 2013.

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O3G-30-3 Spontaneous electrical activity recorded from fibroblast-like cells in the rabbit small intestine

Yoshihiko Kito1),2), Noriyoshi Teramoto1)
1)Dept. Pharmacol., Fac. Med., Saga Univ., 2)Dept. Physiol., Nagoya City Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 114-114, 2013.

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O3G-30-4 Ameliorative action of 5-HT3 receptor antagonist, ondansetron, for postoperative ileus

Toko Maehara, Tatsuro Nakamura, Takahisa Murata, Hiroshi Ozaki, Masatoshi Hori
Vet., Pharmacol. Tokyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 114-114, 2013.

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O3G-30-5 Mast cell-derived prostaglandin D2 inhibits colitis-associated carcinogenesis through suppressing TNF-α signaling

Koichi Iwanaga1), Takahisa Murata1), Masatoshi Hori1), Kosuke Aritake2), Yoshihiro Urade2), Hiroshi Ozaki1)
1)Vet. Pharmacol., The Univ. of Tokyo, 2)Mol. Behav. Biol. Osaka Bioscien. Inst.
Journal of Pharmacological Sciences 121 (suppl) 114-114, 2013.

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O3G-31-1 Effects of insulin resistance on adipogenic differentiation of the stem cells transplanted in cynomolgus monkeys

Takeshi Imamura1), Hirotaka Iwasaki1), Yachiyo Mitsuishi2), Tizuru Iwatani2), Hideaki Tuchiya2), Masashi Tawa1), Takashi Shimosato1), Shinichiro Nakamura2), Tomio Okamura1)
1)Dept. Pharmacol., Shiga Univ. Med. Sci., 2)RCALS, Shiga Univ. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 115-115, 2013.

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O3G-31-2 TGFβ1 and integrinαv-mediated transformation from fibroblast to myofibroblast in an in situ wound-healing model of rat skin

Shozaburo Hata1), Kazuhiko Okamura2), Mitsutoki Hatta3), Taiki Suyama1), Hiroyuki Ishikawa1), Jun Yamazaki3)
1)Dept. Oral Growth Develop., Fukuoka Dent. Coll., 2)Dept. Morphol. Biol., Fukuoka Dent. Coll., 3)Dept. Physiol. Sci. & Mol. Biol., Fukuoka Dent. Coll.
Journal of Pharmacological Sciences 121 (suppl) 115-115, 2013.

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O3G-31-3 Inhibition of GSK-3β accelerates bone formation via the activation of the Wnt/β-catenin signaling pathway

Masaki Arioka1),2), Fumi Takahashi1), Masanori Sasaki2), Toshiyuki Sasaguri1)
1)Dept Clinical Pharmacol., Kyushu Univ., 2)Dept. Oral-Maxillofacial surgery., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 115-115, 2013.

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O3G-31-4 The Rac1 signaling regulates BMP-2 induced osteoblastic differentiation

Megumi Onishi1),2), Yuki Fujita2), Hideki Yoshikawa1), Toshihide Yamashita2)
1)Dept. Orthop., Osaka Univ. Sch. Med., 2)Dept. Molneu., Osaka Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 115-115, 2013.

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O3G-32-1 Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients

Xiaomin Feng1), Yayoi Shikama1), Hideyoshi Noji2),3), Tsutomu Shichishima3), Kazuhiko Ikeda2), Kazuei Ogawa2), Hideo Kimura4), Yasuchika Takeishi2), Junko Kimura1)
1)Dept. Pharmacol., Inst. Med., Univ. Fukushima Med., 2)Dept. Cardiol. and Hematol., Univ. Fukushima Med., 3)Fukushima Res Inst Environ Med., 4)Dept. Hematol., Kita-Fukushima Med Ctr.
Journal of Pharmacological Sciences 121 (suppl) 116-116, 2013.

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O3G-32-2 Effects of diet-induced obesity on aggregation and Ca2+ mobilization in platelets from mice

Fumikazu Matsuhisa1),2), Eiki Satoh2), Emi Iguchi2)
1)United Grad. Sch. Vet. Sci., Gifu Univ., 2)Res. Cent. Animal Hyg. Food Saf., Obihiro Univ. Agric. Vet. Med.
Journal of Pharmacological Sciences 121 (suppl) 116-116, 2013.

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O3G-32-3 CLCA splicing isoform influences cell adhesion through β1-integrin and its scaffolding protein RACK1

Jun Yamazaki1), Kazuhiko Okamura2), Ryo Hiromatsu3), Shozaburo Hata4), Mitsutoki Hatta1)
1)Dept. Physiol. Sci. & Mol. Biol., Fukuoka Dent. Coll., 2)Dept. Morphol Biol., Fukuoka Dent. Coll., 3)Dept. Odontol., Fukuoka Dent. Coll., 4)Dept. Oral Growth Develop., Fukuoka Dent. Coll.
Journal of Pharmacological Sciences 121 (suppl) 116-116, 2013.

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O3G-32-4 Piezo1, a novel mechanosensor in the bladder urothelium

Tatsuya Miyamoto1), Hiroshi Nakagomi1), Satoru Kira1), Tsutomu Mochizuki2), Makoto Tominaga3), Masayuki Takeda1), Schuichi Koizumi4)
1)Dept. Urology., Yamanashi Univ., 2)Dept. Urology., Yamanashi Kosei Hospital, 3)Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, 4)Dept. Pharmacol., Yamanashi Univ.
Journal of Pharmacological Sciences 121 (suppl) 116-116, 2013.

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O3H-33-1 Junctophilin knockdown alters the localization and function of L-type calcium channels and ryanodine receptors in C2C12 myotubes

Tsutomu Nakada1), Bernhard Flucher2), Toshihide Kashihara1), Simmon Gomi1), Mitsuhiko Yamada1)
1)Dept. of Mol. Pharmacol., Shinshu Univ. Sch. of Med, 2)Dept. of Physiol. & Med. Phys., Innsbruck Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 117-117, 2013.

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O3H-33-2 Divergent effects of disease-associated mutations on type 1 ryanodine receptor channel

Takashi Murayama1), Nagomi Kurebayashi1), Hideto Oyamada2), Junji Suzuki3), Kazunori Kanemaru3), Takashi Sakurai2), Masamitsu Iino3), Takashi Sakurai1)
1)Dept. Pharmacol., Juntendo Univ. Sch. Med., 2)Dept. Pharmacol., Sch. Med., Showa Univ., 3)Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 117-117, 2013.

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O3H-33-3 Translation of Ca2+ clock to electrical signal in HEK293 cells heterologously co-expressing ryanodine receptor and Ca2+ activated Cl- channel, TMEM16A

Junya Ohshiro1), Keigo Hashidume1), Hisao Yamamura1), Susumu Ohya2), Yuji Imaizumi1)
1)Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci, Nagoya City Univ., 2)Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 117-117, 2013.

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O3H-33-4 Modification of acetylcholine-induced depressor response by chronic kidney disease in anesthetized rat

Shuhei Kobuchi, Kazuhide Ayajiki
Dept. Pharm., School of Pharm., Hyogo Univ. Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 117-117, 2013.

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O3H-33-5 Predictability of clinical cardiovascular drug responses by halothane-anesthetized Microminipig

Hirofumi Yokoyama1), Yuji Nakamura1), Yasuki Akie1), Hiroyuki Saito1),2), Yukitoshi Nagayama2), Kiyotaka Hoshiai1),2), Atsushi Sugiyama1)
1)Dept. Pharmacol., Faculty of Med., Toho Univ., 2)CMIC BIORESEARCH CENTER
Journal of Pharmacological Sciences 121 (suppl) 118-118, 2013.

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O3H-34-1 Ubiquitin-proteasome-dependent degradation of CDC14A phosphatase via SPSB family of proteins

Tadashi Nishiya1), Ken Maruyama1), Kazuma Matsumoto2), Kouetsu Ogasawara3), Souichi Miwa2), Takashi Uehara1)
1)Dept. Medicinal Pharmacol., Grad. Sch. Med., Dent., Pharm. Sci., Okayama Univ., 2)Dept. Cellular Pharmacol., Hokkaido Univ. Grad. Sch. Med., 3)Dept. Immnol., IDAC, Tohoku Univ.
Journal of Pharmacological Sciences 121 (suppl) 118-118, 2013.

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O3H-34-2 The regulatory mechanism of IQGAP1-dependent endocytosis in pancreatic beta-cells

Toshihide Kimura1), Mami Yamaoka1), Mitsuhiro Okamoto1), Masahiro Takei1), Ray Ishizaki2), Tetsuro Izumi2), Ichiro Niki1)
1)Dept. Pharmacol., Oita Univ. Fac. Med., 2)Lab. Mol. Endocrinol. Metabol., Inst. Mol. Cellular Regulation, Gunma Univ.
Journal of Pharmacological Sciences 121 (suppl) 118-118, 2013.

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O3H-34-3 Molecular basis for the expression of major vault protein induced by hyperosmotic stress

Yusuke Tajitsu1),2), Ryuji Ikeda1),2), Yukihiko Nishizawa2), Tatsuya Yamaguchi1), Masatatsu Yamamoto3), Sho Tabata4), Shin-ichi Akiyama4), Katsushi Yamada5), Tatsuhiko Furukawa3), Yasuo Takeda1),2)
1)Dept. Clin. Pharm., Kagoshima Univ. Hosp., 2)Dept. Clin. Pharm. and Pharmacol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 3)Dept. Mol. Oncology, Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 4)Dept. Med. Oncology, Inst. Health Biosci., Univ. Tokushima Grad. Sch., 5)Dept. Clin. Pharmacol., Faculty of Pharmaceutical Sci., Nagasaki Int. Univ.
Journal of Pharmacological Sciences 121 (suppl) 118-118, 2013.

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O3H-34-4 Neurotoxicity of clioquinol: induction of DNA double-strand breaks and activation of ATM/p53 signaling

Masato Katsuyama1), Chihiro Yabe-Nishimura2)
1)Radioisotope Ctr., Kyoto Pref. Univ. Med., 2)Dept. Pharmacol., Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 121 (suppl) 119-119, 2013.

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O3H-35-1 Protein Methyl Esterase PME-1 protects Protein Phosphatase 2A from ubiquitin/proteasome degradation

Ryotaro Yabe, Takashi Ohama, Koichi Sato
Lab. Vet. Pharmacol., Dep. Vet. Med., Yamaguchi Univ.
Journal of Pharmacological Sciences 121 (suppl) 119-119, 2013.

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O3H-35-2 Cellular responses to LAT1-mediated leucine uptake are revealed by using an LAT1 inhibitor and comprehensive phosphoproteomics

Shushi Nagamori1), Pattama Wiriyasermkul1), Satoshi Serada2), Masaki Matsumoto3), Kenichi Nakayama3), Tetsuji Naka2), Yoshikatsu Kanai1)
1)Bio-System Pharmacol., Osaka Univ. Grad. Sch. Med., 2)Immune Signals, NIBIO, 3)Dept. Mol Cell Biol., MiB Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 119-119, 2013.

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O3H-35-3 Identification of the regions of Duox and Duoxa which play significant roles for hydrogen peroxide production

Megumi Sakuma, Takehiko Ueyama, Takeshi Hamada, Naoaki Saito
Biosignal. Res. Ctr., Kobe Univ.
Journal of Pharmacological Sciences 121 (suppl) 119-119, 2013.

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O3H-35-4 Role of cell-cell interactions in HMGB1 activity in human PBMCs and mouse splenocytes

Kana Ooshima1), Keyue Liu2), Hidenori Wake2), Shuji Mori3), Masahiro Nishibori2), Hideo Takahashi1)
1)Dept. Pharmacol., Kinki Univ. Facul. Med., 2)Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences., 3)Department of Pharmacy, Shujitsu University
Journal of Pharmacological Sciences 121 (suppl) 120-120, 2013.

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O3E-36-1 miR-7a alleviates the maintenance of neuropathic pain by regulating the voltage-gated sodium channel β2 subunit

Atsushi Sakai1), Fumihito Saitow1), Noriko Miyake2), Koichi Miyake2), Takashi Shimada2), Hidenori Suzuki1)
1)Dept. Pharmacol., Nippon Med. Sch., 2)Dept. Biochem. Mol. Biol., Nippon Med. Sch.
Journal of Pharmacological Sciences 121 (suppl) 120-120, 2013.

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O3E-36-2 Elcatonin attenuates oxaliplatin- and paclitaxel-induced peripheral neuropathy by inhibiting the cellular signaling related to TRPA1 and TRPM8 in rats

Manahito Aoki, Yuki Kurauchi, Asami Mori, Tsutomu Nakahara, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 120-120, 2013.

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O3E-36-3 Increased KCC2 expression in PRIP knockout mice ameliorates neuropathic pain

Tomoya Kitayama, Katsuya Morita, Sultana Rizia, Takashi Kanematsu
Dept. Cell. Mol. Pharmacol., Institute Biomed. Health Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 121 (suppl) 120-120, 2013.

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O3E-36-4 Involvement of the long-chain fatty acid receptor GPR40 in CFA-induced inflammatory pain model mice

Kazuo Nakamoto1), Takashi Nishinaka1), Naoya Sato1), Mitsumasa Mankura2), Yutaka Koyama3), Shogo Tokuyama1)
1)Dept. Clinic. Pharm., Fac. Pharmaceu. Sci., Kobe Gakuin Univ., 2)BIZEN CHEMICAL CO. LTD., 3)Lab. Pharmacol, Osaka Ohtani University
Journal of Pharmacological Sciences 121 (suppl) 121-121, 2013.

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O3E-36-5 Multiple profiling of changes in miRNA expression under the neuropathic pain

Akira Yamashita1), Asami Hamada1), Yuki Suhara1), Hironori Saisu1), Eri Shimura1), Michiko Narita1), Naoko Kuzumaki2), Takahiro Ochiya3), Hideyuki Okano2), Minoru Narita1)
1)Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2)Dept. Physiol., Keio Univ. Sch. Med., 3)Section for Studies on Metastasis, National Cancer Center Research Institute
Journal of Pharmacological Sciences 121 (suppl) 121-121, 2013.

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O3E-37-1 Another pathway to produce hydrogen sulfide

Norihiro Shibuya1), Mari Yuasa(Ishigami)1), Makiko Tanaka1), Yuka Kimura1), Yuki Ogasawara2), Kiyoshi Fukui3), Hideo Kimura1)
1)Dept. Mol. Pharm., Natl. Inst. Neurosci., NCNP, 2)Dept. Hygienic Chemistry, Meiji Pharm. Univ., 3)Inst. Enzyme Res., Univ. of Tokushima
Journal of Pharmacological Sciences 121 (suppl) 121-121, 2013.

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O3E-37-2 IL1RAPL1 associated with mental retardation and autism regulates the formation and stabilization of glutamatergic synapses of cortical neurons through RhoA signaling pathway

Takashi Hayashi1), Tomoyuki Yoshida1), Masayoshi Mishina1),2)
1)Dept. Mol. Neurobiol. and Pharmacol., Grad. Sch. Med., Univ. Tokyo, 2)Brain Sci. Lab., Res. Org. Sci. and Tech., Ritsumeikan Univ.
Journal of Pharmacological Sciences 121 (suppl) 121-121, 2013.

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O3E-37-3 Analysis of PKCγ substrates in nigro-striatum system:The role of βPIX phosphorylation in the dopamine release

Toshihiko Shirafuji1), Takehiko Ueyama1), Kenichi Yoshino1), Naoko Adachi1), Hideyuki Takahashi1), Yukio Ago2), Toshio Matsuda2), Naoaki Saito1)
1)Molecular. Pharmacol., Biosignal Res. Ctr., Kobe Univ., 2)Lab. Medicinal Pharmacol. Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 122-122, 2013.

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O3E-37-4 Change of trace elements distributions in mice brain slices of subjected isolation stress

Eiko Sakurai1),2), Keizo Ishii3), Takahiro Sato4), Tomihiro Kamiya4), Nobuyuki Okamura2), Kazuhiko Yanai2)
1)Faculty of Pharmacy Iwaki Meisei Univ., 2)Dept. of Pharmacol. Tohoku Univ. Grad. Sch. Med., 3)Dept. of Quant. Sci. and Engineer. Tohoku Univ., 4)Dept. of Adv. Rad. Tec. TARRI JAEA
Journal of Pharmacological Sciences 121 (suppl) 122-122, 2013.

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O3E-37-5 A behavioral study of learning and memory function in GTRAP3-18-deficient mice

Koji Aoyama1), Fan Wang1), Nobuko Matsumura1), Hiroshi Kiyonari2), Go Shioi2), Karo Tanaka1), Chisato Kinoshita1), Kazue Kikuchi-Utsumi1), Masahiko Watabe1), Toshio Nakaki1)
1)Dept. Pharmacol., Teikyo Univ. Sch. Med., 2)LARGE. Riken. CDB.
Journal of Pharmacological Sciences 121 (suppl) 122-122, 2013.

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O3E-38-1 Direct transcriptional regulation of neuronal transcription factor Npas4 by glucocorticoid receptor

Yoko Hibi, Jaesuk Yun, Taku Nagai, Kiyofumi Yamada
Dept. Neuropsychopharm. and Hosp. Pharm. Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 122-122, 2013.

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O3E-38-2 Involvement of prostaglandin E2 in behavioral abnormalities induced by neonatal immune activation

Hirotake Hida1),2),3),4),5), Akihiro Mouri1), Tomoyuki Furuyashiki2), Kiyofumi Yamada3), Norio Ozaki4), Shuh Narumiya2), Toshitaka Nabeshima5), Yukihiro Noda1)
1)Div. Clin. Sci. Neuropsychopharmcol., Meijo Univ. Grad. Sch. Pharm., 2)Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med., 3)Dept. Neuropsychophamcol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 4)Dept. Psychi., Nagoya Univ. Grad. Sch. Med., 5)Dept. Region. Pharmaceutical Care Sci., Meijo Univ. Fac. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 123-123, 2013.

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O3E-38-3 Exaggerated expression of cortical noradrenaline transporters in the ADHD model rat-Relationship with pharmacological actions of atomoxetine

Taku Yamaguchi1),2), Hiroko Togashi3), Nozomu Kojima3), Sachiko Hiraide3), Machiko Matsumoto3), Masahiko Watanabe4), Tsuneyuki Yamamoto1), Mitsuhiro Yoshioka2)
1)Dept. Pharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ., 2)Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med., 3)Dept. Pharmacol, Fac. Pharmaceut. Sci., Hlth. Sci. Univ. Hokkaido, 4)Dept. Anatomy, Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 123-123, 2013.

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O3E-38-4 Zinc- and Magnesium-Deficiency and Toxic Metal Burdens in the Infants with Autistic Disorders

Hiroshi Yasuda, Toyoharu Tsutsui
La Belle Vie Research Laboratory
Journal of Pharmacological Sciences 121 (suppl) 123-123, 2013.

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O3E-38-5 Psychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice

Mitsunari Nakajima, Hisamichi Mori, Chisa Nishikawa, Momoko Tsuruta, Satoshi Okuyama, Yoshiko Furukawa
Lab. Pharmacol., Matsuyama Univ. Coll. of Pharmaceutical Sci.
Journal of Pharmacological Sciences 121 (suppl) 123-123, 2013.

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O3F-39-1 Glucose metabolism in macrophage suppresses intracellular growth of Mycobacterium tuberculosis

Mayuko Oka1), Sohkichi Matsumoto2), Kazuo Kobayashi3), Masaki Nishiyama4), Masayuki Shiota4), Yasukatsu Izumi4), Katsuyuki Miura5), Hitoshi Iwao4), Yukiko Minamiyama1)
1)Grad. Sch. Life. Enviro. Sci., 2)Dep. Bacteriol. Osaka City. Univ. Grad. Sch., 3)Dep. Immun., Nat. Inst. Infect. Dis., 4)Dep. Pharmacol. Osaka City Univ. Grad. Sch., 5)Dep. Appl Pharmacol. Therap.
Journal of Pharmacological Sciences 121 (suppl) 124-124, 2013.

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O3F-39-2 The nitric oxide reductase of enterohaemorrhagic Escherichia coli plays an important role for the survival within macrophage

Akio Matsumoto2), Takeshi Shimizu1), Hiroyasu Tsutsuki1), Haruaki Nakaya2), Masatoshi Noda1)
1)Dept. Molecular Infectiology, Chiba Univ. Sch. Med., 2)Dept. Pharmacology, Chiba Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 124-124, 2013.

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O3F-39-3 Involvement of leukotriene B4 in dermatophyte extract-induced itch in mice

Tsugunobu Andoh, Yusuke Takayama, Yasushi Kuraishi
Dept. Applied Pharmacol., Grad. Sch. Med. Pharm. Sci., Univ. Toyama
Journal of Pharmacological Sciences 121 (suppl) 124-124, 2013.

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O3F-39-4 Effect of oral administration in mite antigen-induced airway inflammation in mice

Daiki Yamakoshi1), Kanako Inoue1), Hirotaka Yamashita1),2), Naoki Inagaki1),2), Hiroyuki Tanaka1),2)
1)Lab. Pharmacol., Dept. Bioactive Mol., Gifu Pharm. Univ., 2)United Grad. Sch. Drug Disc. Med. Inform. Sci. Gifu Univ.
Journal of Pharmacological Sciences 121 (suppl) 124-124, 2013.

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O3E-40-1 Kinetic analysis of 3F-L-α-methyltyrosine (FAMT) transport by L-type amino acid transporter 1

Ling Wei1), Hideyuki Tominaga2), Pattama Wiriyasermkul1), Yumiko Nishinaka1), Ryuichi Ohgaki1), Kenjiro Tadagaki1), Shushi Nagamori1), Yoshikatsu Kanai1)
1)Div. of Biosystem Pharmacol., Dept. of Pharmacol., Grad. Sch. of Med., Osaka Univ., 2)Dept. of Mol. Imaging, Funma Univ. Grad. Sch. of Med.
Journal of Pharmacological Sciences 121 (suppl) 125-125, 2013.

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O3F-40-2 Controlled drug delivery and magnetic resonance imaging with intrinsic ferromagnetic nano-particle compound

Haruki Eguchi1), Kunio Hirata2), Reiko Kurotani3), Hidenobu Fukumura4), David Singh5), Masahiro Yamamoto6), Itaru Sato4), Masanori Umemura4), Masaki Yamamoto2), Mamoru Sato7), Yoshihiro Ishikawa4)
1)Research Lab. IHI, 2)RIKEN/SPring-8, 3)Faculty of Engineering, Yamagata University, 4)Graduate school of Medicine, Yokohama City University, 5)Oak Ridge National Laboratory, 6)Faculty of Science and Engineering, 7)International Graduate School of Arts and Sciences
Journal of Pharmacological Sciences 121 (suppl) 125-125, 2013.

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O3F-40-3 The search for diagnostic biomarkers of multiple myeloma by the identification of Hsp72-binding proteins

Satoshi Nishi1), Masako Tanaka1), Ryo Uemura1), Takafumi Nakao1), Yasuyuki Ohkawa2), Hideki Wanibuchi3), Yasukatsu Izumi1), Katsuyuki Miura4), Masayuki Shiota1), Hiroshi Iwao1)
1)Dept. Pharmacol., Osaka City Univ. Grad. Sch. Med., 2)Div. Epigenetics, Kyushu Univ. Grad. Sch. Med., 3)Dept. Pathol., Osaka City Univ., Grad. Sch. Med., 4)Appl. Phrmacol. Ther., Osaka City Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 125-125, 2013.

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O3F-40-4 Loss of tumor suppressor CYLD triggers cell invasion of human oral squamous cell carcinoma cells

Hirofumi Jono1),2), Satoru Shinriki3), Konen Obayashi3), Yukio Ando4)
1)Dept. Pharmacy, Kumamoto Univ. Hosp., 2)Dept. Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto Univ., 3)Diagnostic Unit for Amyloidosis, Dept. of Laboratory Medicine, Kumamoto Univ. Hosp., 4)Det. Neurology, Graduate School of Life Sciences, Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 125-125, 2013.

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O3F-40-5 Intramolecular regulatory mechanism of degradation of chronic myeloid leukemia oncoprotein, BCR-ABL

Fujiko Tsukahara, Yoshiro Maru
Dept. Pharmacol., Tokyo Women's Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 126-126, 2013.

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O3F-41-1 Anti-system L transporter therapy for prostate cancer

Hideo Otsuki1), Toru Kimura1), Toshiyuki Fukutomi1), Takeshi Marumo1), Hitoshi Endou12), Hiroyuki Sakurai1)
1)Dept. Pharmacol., Kyorin Univ., 2)J-Pharma, Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 126-126, 2013.

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O3F-41-2 Analysis of miRNA expression after irradiation in glioblastoma cell lines

Akiko Sasaki1), Yuko Udaka1), Yuko Tsunoda3), Mayumi Tsuji1), Hideto Oyamada1), Tohru Mizutani2), Katsuji Oguchi1)
1)Dept. Pharmacol., Showa Univ. Sch. Med., 2)Dept. Neurosurgery., Showa Univ. Sch. Med., 3)Kameda Medical Center
Journal of Pharmacological Sciences 121 (suppl) 126-126, 2013.

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O3F-41-3 Role of Angiotensin Type 1a Signaling in Tumor Metastasis Formation Through Increased Adhesion of Platelets

Hideki Amano1),2), Yoshiya Ito3), Fumihiro Ogawa2), Kouji Eshima4), Masataka Majima2)
1)Dept. Clinical Research Center Kitasato University School of Medicine, 2)Dept. Pharmacology Kitasato University School of Medicine, 3)Dept. Surgery Kitasato University School of Medicine, 4)Dept. Immunology Kitasato University School of Medicine
Journal of Pharmacological Sciences 121 (suppl) 126-126, 2013.

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O3F-41-4 Anti-Tumor Effect of Differentiation-Inducing Factors on a Colon Cancer Cell Line HCT-116

Naoya Kubokura1),2), Fumi Takahashi1), Takayuki Matsumoto2), Toshiyuki Sasaguri1)
1)Dept. Clinical Pharmacol., Kyushu Univ. Sch. Med., 2)Dept. Medicine and Clinical Science, Kyushu Univ. Sch. Med
Journal of Pharmacological Sciences 121 (suppl) 127-127, 2013.

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O3G-42-1 Negative regulation of exocytosis by PRIP through intermolecular interactions

Hiroshi Takeuchi1), Zhao Zhang2), Jing Gao2), DaGuang Wang2), Masato Hirata2)
1)Dev. Appl. Pharmacol., Kyushu Dental Coll., 2)Lab. Mol. Cell. Biochem., Fac. Dental Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 127-127, 2013.

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O3G-42-2 Binding of [3H] SCH23390 to Dopamine D1 receptor synthesized with liposomes

Eiji Arimitsu1),2), Tomio Ogasawara3), Yoich Hiasa2), Morikazu Onji2), Tatsuya Sawazaki3), Kazutaka Maeyama1)
1)Dept. Pharmacol., Ehime Univ. Sch. Med., 2)Dept. Gastroenterology and Metabology., Ehime Univ. Sch. Med., 3)Cell-Free Science and technology Center., Ehime Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 127-127, 2013.

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O3G-42-3 p-Quinone monooximes, prepared as a synthetic precursor of macarpine, induce cell death via mitotic arrest

Hiromi Sato1), Sayumi Suzuki1), Midori Yanagihara1), Ryota Yamada1), Ayako Kurosawa2), Noriyuki Suzuki2), Tsutomu Ishikawa2), Koichi Ueno1)
1)Dept. of Geriatric Pharmacological and Therapeutics, Grad. Sch. of Pharmaceut. Sci, Chiba Univ., 2)Dept. of Medicinal Organic Chemistry, Grad. Sch. of Pharmaceut. Sci, Chiba Univ.
Journal of Pharmacological Sciences 121 (suppl) 127-127, 2013.

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O3G-42-4 Molecular basis for the induction of vaults by hyperosmotic stress, and the role of vaults in resistance to hyperosmotic stress

Ryuji Ikeda1),2), Yusuke Tajitsu1),2), Yukihiko Nishizawa2), Tatsuhiko Furukawa3), Shin-ichi Akiyama4), Katsushi Yamada5), Yasuo Takeda1),2)
1)Dept. Clin. Pharm., Kagoshima Univ. Hosp., 2)Dept. Clin. Pharm. and Pharmacol., Grad Sch. Med. and Dent. Sci., Kagoshima Univ., 3)Dept. Mol. Oncology, Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 4)Dept. Med. Oncology, Inst. Health Biosci., Univ. Tokushima Grad. Sch., 5)Dept. Clin. Pharmacol., Faculty of Pharmaceutical Sci., Nagasaki Int. Univ.
Journal of Pharmacological Sciences 121 (suppl) 128-128, 2013.

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O3G-42-5 Differential cellular effects of two glycosyl resveratrols

Ryusuke Hosoda1), Atushi Kuno1),2), Yusuke Hori1), Azusa Oohiro3), Hiroki Hamada3), Yoshiyuki Horio1)
1)Dept. Pharmacol., Sapporo Med. Univ. Sch. Med., 2)Dept. 2nd. Int. Med., Sch. of Med., Sapporo Med. Univ., 3)Dept. Life. Sci., Okayama Sci. Univ. Sch. Sci.
Journal of Pharmacological Sciences 121 (suppl) 128-128, 2013.

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O3G-43-1 A novel mouse model of chronic inflammatory and overactive bladder by a single intravesical injection of hydrogen peroxide

Takashi Homan, Tetsunori Tsuzuki, Koji Dogishi, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol Pharm., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 128-128, 2013.

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O3G-43-2 Regulation of intracellular Ca2+ dynamics in pregnant and non-pregnant mouse myometrium

Katsuhito Matsuki1), Masashi Takemoto1), Hisao Yamamura1), Susumu Ohya2), Hiroshi Takeshima3), Yuji Imaizumi1)
1)Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2)Dept. Pharmacol., Kyoto Pharm. Univ., 3)Dept. Biol. Chem., Grad. Sch. Pharmceut. Sci, Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 128-128, 2013.

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O3G-43-3 Effect of Hydroxyfasudil on penile dysfunction in the male spontaneously hypertensive rat

Motoaki Saito, Shogo Shimizu, Tsounapi Panagiota, Ryo Oikawa, Yukako Kinoshita, Keisuke Satoh, Shuhei Tomita
Divi. Mol. Pharmacol., Tottori Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 129-129, 2013.

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O3G-43-4 Testicular ischemic postconditioning protection via the activation of mitochondrial KATP channel

Ryo Oikawa, Shogo Shimizu, Panagiota Tsounapi, Yukako Kinoshita, Shuhei Tomita, Keisuke Satoh, Motoaki Saito
Div. of Molecular Pharmacol., Tottori Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 129-129, 2013.

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O3G-43-5 Ghrelin attenuates cAMP signaling to evoke insulinostatic cascade in islet β-cells

Katsuya Dezaki, Boldbaatar Damdindorj, Rauza Rita, Toshihiko Yada
Dept. Physiol., Jichi Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 129-129, 2013.

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O3H-44-1 Imaging of neuronal activities at the single-cell and the single-synapse levels using high-sensitivity and fastresponsivity G-CaMP-type genetically encoded calcium indicators

Masamichi Ohkura1), Junko Sadakari1), Takuya Sasaki1), Keiko Gengyo-Ando1), Yuko Kagawa-Nagamura1), Chiaki Kobayashi2), Yuji Ikegaya2), Junichi Nakai1)
1)Saitama Univ. Brain Sci. Inst., 2)Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 129-129, 2013.

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O3H-44-2 Imaging of neuronal spikes evoked by photo-stimulation of channelrhodopsin-2 using R-CaMP1.07, an improved genetically encoded red fluorescent calcium indicator

Masamichi Ohkura1), Takuya Sasaki1), Chiaki Kobayashi2), Yuji Ikegaya2), Junichi Nakai1)
1)Saitama Univ. Brain Sci. Inst., 2)Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 130-130, 2013.

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O3H-44-3 New screening system of blockers selective to Kv channels using recombinant cell line dying upon single action potential

Masato Fujii1), Hisao Yamamura1), Susumu Ohya2), Yuji Imaizumi1)
1)Dept. ol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci, Nagoya City Univ., 2)Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 130-130, 2013.

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O3H-44-4 Zebrafish-based quantitative and systems pharmacology of the BBB permeability to fluorescent indoline derivatives

Yuhei Nishimura1),2),3),4), Noriko Umemoto1), Zi Zhang1), Beibei Zhang1), Yasuhito Shimada1),2),3),4), Toshio Tanaka1),2),3),4)
1)Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2)Mie University Medical Zebrafish Research Center, 3)Department of Omics Medicine, Mie University Industrial Technology Innovation Institute, 4)Department of Bioinformatics, Mie University Life Science Research Center
Journal of Pharmacological Sciences 121 (suppl) 130-130, 2013.

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O3H-44-5 Zebrafish-based Quantitative and Systems Pharmacology for Appetite-regulating Gene and Drug Screening

Yasuhito Shimada1), Junya Kuroyanagi1), Noriko Umemoto1), Beibei Zhang1), Michiko Ariyoshi1), Yuhei Nishimura1),2),3),4), Toshio Tanaka1),2),3),4)
1)Dept. Pharmacol., Mie Univ. Grad. Sch. Med., 2)Mie Univ. Med. Zebra, 3)Dept. Bioinfo. Mie Univ. Life Sci., 4)Dept. Omics, Mie Univ. Indust. Tech. Innov.
Journal of Pharmacological Sciences 121 (suppl) 130-130, 2013.

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O3H-45-1 Protective effect of daily dietary n-3 polyunsaturated fatty acid supplementation against age-related cognitive decline in elderly Japanese with very mild dementia: A 2-year randomized, double-blind, placebo-controlled trial

Michio Hashimoto1), Kazuya Yamashita2), Setsushi Kato3), Tadakazu Tamai4), Yoko Tanabe1), Makoto Mitarai4), Ichie Matsumoto2), Miho Ohno3)
1)Dept. Environment. Physiol. Shimane Univ. Facult. Med., 2)Shimane Nursing Coll., 3)Jinjukai Kato Hospital, 4)Cent. Res. Inst. Maruha Nichiro Hold. Inc.
Journal of Pharmacological Sciences 121 (suppl) 131-131, 2013.

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O3H-45-2 Mechanism of reduction of vuseral fat volume by enokitake-linoleic acid

Yasuo Watanabe1), Koshi kubo2), Hiroshi Saito3), Yoshihiko Ito4), Hiroaki Tokiwa5), Shizuo Yamada4)
1)Dept. Pharmacol., Nihon Pharm Univ. Sch. Pharm. Sci., 2)Dept. Anal. Chem. Nihon Pharm Univ. Sch. Pharm. Sci., 3)Edu. Centr. Integrat. Med., Nihon Pharm Univ. Sch. Pharm. Sci., 4)Dept P.K. and P.D., University of Shizuoka, Sch. Pharm. Sci., 5)Dept. Chem., Rikkyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 131-131, 2013.

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O3H-45-3 Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish

Takahiro Hasumura1), Yasuhito Shimada2),3),4),5), Junya Kuroyanagi2), Yuhei Nishimura2),3),4),5), Shinichi Meguro1), Yoshinori Takema6), Toshio Tanaka2),3),4),5)
1)Biological Science., Kao. Co., 2)Dept. Mol. and Cell. Pharmacol., Pharmacogeno. and Pharmacoinfor., Mie Univ. Grad. Sch. Med., 3)Mie Univ. Med. Zebra. Res. Cent., 4)Dept. Bioinfo. Mie Univ. Life Sci. Res. Cent., 5)Dept. Omics Med., Mie Univ. Indu. Tech. Innou Inst., 6)Research & Development., Kao. Co.
Journal of Pharmacological Sciences 121 (suppl) 131-131, 2013.

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O3H-45-4 Liposome-encapsulated hemoglobin (hemoglobin-vesicle) is not transferred from mother to fetus at the late stage of pregnancy in the rat model

Heng Li1), Maiko Kaga2), Hidenobu Ohta1), Masumi Inagaki1), Hitomi Izumi1), Hiromi Sakai3)
1)Dept. Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, 2)Center for Perinatal Medicine, Tohoku University Hospital, 3)Waseda Bioscience Research Institute in Singapore, Waseda University
Journal of Pharmacological Sciences 121 (suppl) 131-131, 2013.

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O3H-45-5 Label-free, rapid and reliable new chemosensitivity test for physiological concentration of anti-cancer drug: evaluation within 1 h

Toshihiro Ona, Junko Shibata
Grad. Sch. Biores. Bioenv. Sci., Kyushu Univ., Precision Bio-Engineering Co.
Journal of Pharmacological Sciences 121 (suppl) 132-132, 2013.

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P1-1 Dextromethorphan inhibits spontaneous excitatory synaptic transmission through cAMP-PKA cascade in the guinea pig nucleus tractus solitarius slices

Yoshiaki Ohi, Satoko Kimura, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 134-134, 2013.

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P1-2 L-DOPA induces Ca2+ response via L-DOPA receptor candidate, OA1

Moemi Kaneda1),2), Fumio Nakamura1), Hidenori Muraoka1), Yoshio Goshima1)
1)Dept. mol. Pharmacol., Grad. Sch. Med. Yokohama Ctiy Univ., 2)Lab. Cell. Neurobiol., Sch. Life Sci., Tokyo Univ. Pharm. & Life Sci.
Journal of Pharmacological Sciences 121 (suppl) 134-134, 2013.

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P1-3 Immunohistochemical examination of OA1, a novel DOPA receptor, in the CNS

Marina Kamiya, Naoya Yamashita, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima
Dept of Mol Pharmacol, Yokohama City Univ.
Journal of Pharmacological Sciences 121 (suppl) 134-134, 2013.

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P1-4 Mechanisms of retinoid-induced nNOS upregulation and neurite elongation in SH-SY5Y cells

Tatsuya Fujibayashi, Yuki Kurauchi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki
Dept. Chemico-Pharmacol Sci. Grad Sch Pharm Sci, Kumamoto Uni.
Journal of Pharmacological Sciences 121 (suppl) 134-134, 2013.

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P1-5 Organotypic hippocampal slice cultures for studies of amyloid precursor protein processing

Yuji Kamikubo, Takashi Sakurai
Dept. Pharmacol., Juntendo Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 135-135, 2013.

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P1-6 Effect of GABA(A) receptors activation on ethanol-induced type 1 IP3 receptors up-regulation

Koji Mizuno, Kazuhiro Kurokawa, Seitaro Ohkuma
Dept. Pharmacol., Kawasaki Med. Sch.
Journal of Pharmacological Sciences 121 (suppl) 135-135, 2013.

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P1-7 5-HT1B receptor-mediated presynaptic inhibition of GABA release onto cholinergic neurons in the rat basal forebrain

Takuma Nishijo1),2), Toshihiko Momiyama1)
1)Dept Pharmacol, Jikei Univ Sch of Med,, 2)Dept Pharmacol, Sch of Pharm, Keio Univ
Journal of Pharmacological Sciences 121 (suppl) 135-135, 2013.

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P1-8 Involvement of 5-HT4 receptor on differentiation of mouse induced pluripotent stem cells into neural progenitor cells

Ayako Ozawa, Toshiaki Ishizuka, Hazuki Goshima, Yasuhiro Watanabe
Dept. Pharmacol., Natl. Def. Med. Col.
Journal of Pharmacological Sciences 121 (suppl) 135-135, 2013.

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P1-9 Protection by DHH-B against amyloidβ1-42 suppression of viability and neurite elongation in rat hippocampal cells

Yasuhisa Nakayama, Tomoyuki Nakamura
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 136-136, 2013.

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P1-10 Effects of anti-14-3-3 antibodies on the 15-deoxy-Δ12,14-prostaglandin J2-induced neuronal cell death

Yasuhiro Yamamoto1), Hiromi Koma1), Hiroki Hiramatsu1), Misa Abe1), Tsutomu Nakamura2), Tatsurou Yagami1)
1)Div. Physiol., Fac. Pharmaceut. Sci., Himeji Univ., 2)Div. Pharmaceutics, Fac. Pharmaceut. Sci., Himeji Dokkyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 136-136, 2013.

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P1-11 Neural network analysis of an in vitro epilepsy model using functional multineuron calcium imaging

Yoshie Hongo1), Keiko Takasu1), Koichi Ogawa1), Yuji Ikegaya2), Minoru Hasegawa1), Gaku Sakaguchi1)
1)Pain & Neurology, Med. Res. Lab., SHIONOGI, 2)Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo
Journal of Pharmacological Sciences 121 (suppl) 136-136, 2013.

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P1-12 Tipepidine inhibits noradrenaline α2 receptors-mediated GIRK channel current and activates locus coeruleus neurons

Ryota Hamasaki, Tetsuya Shirasaki, Fumio Soeda, Kazuo Takahama
Dept. Environ. Mol. Health Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 136-136, 2013.

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P1-13 Possible involvement of NF-κB in WDR35 expression in bupivacaine-treated neuro2a cells

Lei Huang, Fumio Kondo, Guo-Gang Feng, Koji Tsunekawa, Naohisa Ishikawa, Shoshiro Okada
Dept. Pharmacol., Aichi Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 137-137, 2013.

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P1-14 Paroxetine prevented the activation of microglia by suppressing P2X4 receptor activation

Koki Fujimori1),2), Junpei Takaki1),2), Kaoru Sato2), Takeshi Suzuki1)
1)Div Basic Biol Sci, Fac Pharm, Keio Univ, 2)Div Pharmacol, Natl Inst Health Sci
Journal of Pharmacological Sciences 121 (suppl) 137-137, 2013.

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P1-15 Molecular Mechanism of Histamine Clearance by Human Astrocytes

Takeo Yoshikawa1), Fumito Naganuma1), Tomomitsu Iida1), Tadaho Nakamura1), Atsuko Kasajima2), Hironobu Sasano2), Kazuhiko Yanai1)
1)Dept. Pharmacol., Tohoku Univ. Grad Sch. Med., 2)Dept. Anat Pathol., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 137-137, 2013.

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P1-16 Searching for analgesics targeted at P2X4 receptors using screening systems

Tomohiro Yamashita, Ayumi Hasegawa, Keiko Tominaga, Sawako Kamikaseda, Jiaming Zhang, Makoto Tsuda, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol., Grad. sch. Pharm Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 137-137, 2013.

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P1-17 Expression of CNT in astrocytes and mechanism of thymidine incorporation into acid insoluble fraction on oxidative stress DNA injury

Koh-ichi Tanaka1),2),3), Nobue Kitanaka2), Junichi Kitanaka2), Shyohn Yokoyama1), Junya Hanatani1), Minse Pak1), Teruhisa Miyake1), Haruna Oh-i1), Yuriko Kishi1), Tomoaki Sato3), Takashige Nishikawa3), Motohiko Takemura2), Akemichi Baba1), Nobuyoshi Nishiyama1)
1)Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., 2)Dept. Pharmacol., Hyogo Col. Med., 3)Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. & Dent. Sci.
Journal of Pharmacological Sciences 121 (suppl) 138-138, 2013.

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P1-18 Neuroprotective effects of serotonin-1a agonist 8-OH-DPAT target astrocytes

Ikuko Miyazaki1), Shinki Murakami1), Mika Takeshima1), Nao Torigoe2), Ko Miyoshi1), Yoshihisa Kitamura2), Masato Asanuma1)
1)Dept. of Brain Sci., Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci., 2)Dept. of Clinical Pharmacy, Okayama Univ. Grad. Sch. of Med., Dent. & Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 138-138, 2013.

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P1-19 Region-specific astrocytic features and neuroprotections targeting anti-oxidative system of astrocytes

Nao Torigoe1), Ikuko Miyazaki2), Shinki Murakami2), Toshihiro Koyama1), Yoshihisa Kitamura1), Masato Asanuma2)
1)Dept. Clinical Pharmacy, Okayama Univ. Grad. Sch. of Med., Dent. & Pharmaceut. Sci., 2)Dept. of Brain Science, Okayama Univ. Grad. Sch. of Med., Dent. & Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 138-138, 2013.

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P1-20 Contribution of infiltrated monocyte/macrophages to neuropathological changes of cathepsin D-deficient mice

Ryo Okada, Zhou Wu, Junjun Ni, Hiroshi Nakanishi
Dept. Aging Sci. Phamacol., Fac. Dent. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 138-138, 2013.

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P1-21 Microglia-derived ATP triggers astrocytic P2Y1 receptor-mediated IL-6 production and neuroprotection

Youichi Shinozaki, Schuichi Koizumi
Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi
Journal of Pharmacological Sciences 121 (suppl) 139-139, 2013.

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P1-22 Effect of mutant SOD1 expression in astrocytes on the noradrenaline-induced astrocyte-mediated neuroprotection

Yasuhiro Yoshioka, Masato Akune, Takahide Yoshida, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.
Journal of Pharmacological Sciences 121 (suppl) 139-139, 2013.

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P1-23 A calcium-dependent mechanism for the transformation of input patterns into Cdc42 activity in neurons revealed by novel fluorescent indicators

Yusaku Ohta, Syunsuke Kishi, Shigeyuki Namiki, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 139-139, 2013.

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P1-24 Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons

Mahomi Kuroiwa, Miho Hamada, Eriko Hieda, Takahide Shuto, Naoki Sotogaku, Akinori Nishi
Dept. Pharmacol., Kurume Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 139-139, 2013.

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P1-25 Acute effects of resveratrol on cocaine-induced dopamine neurotransmission in the striatum

Takahide Shuto, Mahomi Kuroiwa, Yuki Koga, Yukie Kawahara, Naoki Sotogaku, Akinori Nishi
Dept. Pharmacol., Kurume Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 140-140, 2013.

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P1-26 Detection of intercellular signaling by BACE1-dependent proteolysis of neuregulin 1 using a cleavage site-specific antibody

Taku Kashiyama, Yuji Kamikubo, Takashi Sakurai
Dept. Pharmacol., Juntendo Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 140-140, 2013.

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P1-27 Phosphorylation of Ca2+/calmodulin-dependent protein kinase Iβ2 induced by glutamate in cortical neurons

Narumi Hasegawa, Ai Saito, Yuri Matsuo, Mitsuo Tanabe, Yasuhito Naito
Dept. Pharmacol., Sch. Pharmac. Sci. Kitasato Univ.
Journal of Pharmacological Sciences 121 (suppl) 140-140, 2013.

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P1-28 Bradykinin-induced phosphorylation of Ca2+/calmodulin-dependent protein kinase Iβ2 in Neuro2A cells

Yasuhito Naito, Yukari Terunuma, Yuri Matsuo, Mitsuo Tanabe
Dept. Pharmacol., Sch. Pharmac. sci., Kitasato Univ.
Journal of Pharmacological Sciences 121 (suppl) 140-140, 2013.

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P1-29 In vivo glutamate imaging in the cerebral cortex

Hiroshi Sekiya1), Hirokazu Sakamoto2), Shigeyuki Namiki2), Kenzo Hirose2), Masamitsu Iino1)
1)Dept. Pharmacol., Univ. Tokyo Grad. Sch. Med., 2)Dept. Neurobiol., Univ. Tokyo Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 141-141, 2013.

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P1-30 Hippocampal neurogenesis and synaptic plasticity at the Schaffer collateral-CA1 synapse in mice fed an exclusively milk formula diet after weaning

Toshiaki Ishii, Hideaki Nishie, Yoshikage Muroi
Dept. Basic Vet. Med., Obihiro Univ. of Agri. and Vet. Med.
Journal of Pharmacological Sciences 121 (suppl) 141-141, 2013.

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P1-31 Action mechanism of the beneficial effects of betaine on homocysteine-induced memory impairment

Kazuo Kunisawa1), Natsuki Nakashima1), Saori Kinoshita1), Toshitaka Nabeshima1),2), Masayuki Hiramatsu1),3)
1)Dept. Pharmacol., Fac. Pharmac., Meijo Univ., 2)Dept. Region. Pharmac. Care & Sci., 3)Lab. Neuropsychopharmacol, Grad. Sch. Environ. & Human Sci.
Journal of Pharmacological Sciences 121 (suppl) 141-141, 2013.

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P1-32 Ferulic acid inhibits learning and memory impairments induced by chronic cerebral hypoperfusion in rats

Hirokazu Matsuzaki1), Kimiko Aoyagi1), Naoko Kimura1), Yumiko Kiso1), Yukari Nakata1), Saika Kato1), Yasuhide Hibino2), Mari Okazaki1)
1)Pharmacol., Fac. Pharm. Sci., Josai Univ., 2)Immunobiochem., Fac. Pharm. Sci., Josai Univ.
Journal of Pharmacological Sciences 121 (suppl) 141-141, 2013.

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P1-33 The Test System of Parkinson model monkey induced by MPTP

Hironobu Ikeda, Akihito Ito, Takahito Watabe, Hiroshi Sakonjo, Mikito Kikumori, Akihiro Ishimoto, Kagari Kimura, Shigenori Furukawa
Research Dep., Shiga Lab., NISSEI BILIS Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 142-142, 2013.

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P1-34 Fasudil, a rho kinase inhibitor, prevents motor neuronal loss and improves the pathology in amyotrophic lateral sclerosis

Masafumi Takata1), Hirotaka Tanaka1), Masataka Kimura1), Yuki Nagahara1), Kosuke Tanaka2), Koh Kawasaki2), Kazuhiro Tsuruma1), Masamitsu Shimazawa1), Hideaki Hara1)
1)Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ., 2)Pharmaceuticals Research Center, Asahi Kasei Pharma corporation
Journal of Pharmacological Sciences 121 (suppl) 142-142, 2013.

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P1-35 Neuroprotective effects of SUN N8075 on neuronal cell death in the Huntington's disease mice

Yasuhiro Noda1), Hirotaka Tanaka1), Yasushi Ito1), Nobutaka Morimoto1), Kazuhiro Tsuruma1), Masamitsu Shimazawa1), Michinori Kadokura2), Shigeki Tamura2), Teruyoshi Inoue2), Hideaki Hara1)
1)Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ., 2)Asubio Pharma Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 142-142, 2013.

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P1-36 Protective effects of SUN N8075 on the light-induced retinal damage

Kazuki Ojino1), Tomohiro Nakanishi1), Masaki Nishiguchi1), Yuta Ohno1), Tomohiro Otsuka1), Kazuhiro Tsuruma1), Masamitsu Shimazawa1), Michinori Kadokura2), Shigeki Tamura2), Teruyoshi Inoue2), Hideaki Hara1)
1)Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmacent. Univ., 2)Asubio Pharma Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 142-142, 2013.

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P1-37 Histone deacetylase(HDAC) inhibitor attenuates amyloid beta-induced synaptic dysfunction

Yuta Ishizuka, Hideo Shimizu, Eiko Takagi, Tomoaki Shirao
Dept. Neurobiol & Behav, Gunma Univ Grad Sch Med
Journal of Pharmacological Sciences 121 (suppl) 143-143, 2013.

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P1-38 Prostaglandin E2-induced cell death is mediated by activation of EP2 receptors in motor neuron-like NSC-34 cells

Yasuhiro Kosuge, Hiroko Miyagishi, Nobuhiro Osada, Kumiko Ishige, Yoshihisa Ito
Lab. of Pharmacol., Sch. of Pharm., Nihon Univ.
Journal of Pharmacological Sciences 121 (suppl) 143-143, 2013.

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P1-39 Effects of shikonin on neurodegenerative diseases (Alzheimer's disease and Parkinson's disease): a preliminary study in an animal model of both diseases

Taizo Taniguchi1),3), Lucia Satiko Yoshida2), Hiroaki Shichiri1), Aimi Watanabe1), Mariko Takenokuchi1), Keiichi Kadoyama1), Kazuhide Miyamoto1), Hiromi Takano-Ohmuro2)
1)Dept. Pharmaceutical Health Care, Fac. Phamaceutical Sci., Himeji Dokkyo Univ., 2)Fac. Pharmacy & Res. Inst. Pharmaceutical Sci., Musashino Univ., 3)Pharmacrea Kobe Co. Ltd.
Journal of Pharmacological Sciences 121 (suppl) 143-143, 2013.

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P1-40 Influence of doxorubicin and cyclophosphamide on psychological behavior in rats

Yoshihisa Kitamura1), Sayo Hattori1), Ayaka Miyake1), Toshihiro Koyama1), Ikuko Miyazaki2), Masato Asanuma2), Toshiaki Sendo1)
1)Dept. Clin. Pharmacy, Okayama Univ. Grad. Sch., 2)Dept. Brain Sci., Okayama Univ. Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 143-143, 2013.

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P1-41 Serine system changes in isolated mutant DISC1 mice

Yurie Matsumoto1),2),3), Ziyu Song4), Mayuko Koshikawa4), Shoko Watanabe4), Dan Ge4), Minae Niwa2),5), Akihiro Mouri3), Hideaki Iizuka4), Akira Sawa5), Yukihiro Noda3),7), Takeshi Fukushima4), Norio Ozaki1), Toshitaka Nabeshima2),6),7)
1)Dept. Psychi, Nagoya Univ. Grad. Sch. Med., 2)Dept. Chem. Pharmacol., Meijo Univ. Grad. Sch. Pharm. Sci., 3)Division, Clinical Sci., & Neuropsychopharmacol., Meijo Univ. Grad. Sch. Pharm. Sci., 4)Dept. Analytical Chem., Toho Univ. Grad. Sch. Pharm. Sci., 5)Dept. Psychi. & Behav. Sci., Johns Hopkins Univ. Sch. Med., 6)Dept. Regional Pharmaceutical Care & Sci., Meijo Univ. Grad. Sch. Pharm. Sci., 7)Japanese Drug Organization of Appropriate Use and Research
Journal of Pharmacological Sciences 121 (suppl) 144-144, 2013.

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P1-42 Studies of drug dependence (Rept. 490) Differential antagonizing effects of clozapine and haloperidol on the methamphetamine- and morphine-induced behavioral changes

Noriyuki Iwata, Tomohisa Mori, Asammi Murata, Masahiro Shibasaki, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 144-144, 2013.

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P1-43 Acute morphine exposure impairs spatial memory in mice

Nobue Kitanaka1), Junichi Kitanaka1), Akiko Goto1), Satoko Mibayashi1), Yusuke Kanda1), Yumi Muranishi1), Koh-ichi Tanaka2), Nobuyoshi Nishiyama2), Motohiko Takemura1)
1)Dept. Pharmacol., Hyogo Col. Med., 2)Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Hlth. Sci.
Journal of Pharmacological Sciences 121 (suppl) 144-144, 2013.

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P1-44 Effect of the 5-HT1A receptor function on antidepressive effect and neurogenesis in ACTH treated rats

Ayaka Miyake1), Yoshihisa Kitamura1), Sayo Hattori1), Toshihiro Koyama1), Ikuko Miyazaki2), Masato Asanuma2), Toshiaki Sendo1)
1)Dept. Clin. Pharmacy, Okayama Univ. Grad. Sch., 2)Dept. Brain Sci., Okayama Univ. Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 144-144, 2013.

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P1-45 molecular structure of nAChR ligand(1)

Taizou Hayano1), Shiroh Kishioka2), Hiroyuki Yamamoto2)
1)Div. Psychiat. Asahikaiwakaurabyouin, 2)Dept. Pharmacol. Wakayama-med. Sch. Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 145-145, 2013.

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P1-46 Indication of Fluvoxamine in Dexamethasone-continuous infusion mice for locomoter activity and gene expression of serotonin-associating factors

Kazuki Terada1), Biora Suzuki1), Norifumi Shimizu2), Ayumi Fujikawa1), Michio Kimura3), Minehiro Moriyama2), Chiaki Hara2), Nobuo Izumo1)
1)Dept. Clin. Pharmacol., Yokohama Coll Pharm., 2)Dept. Pharmacol., Daiichi Univ. Col. of Pharmac. Sci., 3)Dept. Microbiol. and Mol. Cell Biol., Nihon Pharmaceut. Univ.
Journal of Pharmacological Sciences 121 (suppl) 145-145, 2013.

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P1-47 Comparison of serotonergic system in WKY and Wistar rats

Makiko Yamada1), Yukie Kawahara1), Fumi Kaneko1), Yuki Kishikawa1), Hiroshi Kawahara2), Akinori Nashi1)
1)Dept. Pharmacol., Kurume Univ. Sch. Med., 2)Dept. Dental Anesthesiology, Tsurumi Dental College
Journal of Pharmacological Sciences 121 (suppl) 145-145, 2013.

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P1-48 The effect of forced swimming on the level of FGF20 in hippocampus of ddY mice

Toru Oda, Tomohiro Tanioka, Tetsuya Munemoto, Kumatoshi Ishihara
Laboratory of Neuropharmacol., Faculty of Pharm. Sci., Hiroshima Int. Univ.
Journal of Pharmacological Sciences 121 (suppl) 145-145, 2013.

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P1-49 The effect of pentazocine on monoamine transporter activity

Go Obara2), Yumiko Toyohira2), Hirohide Inagaki2), Keita Takahashi2), Susumu Ueno3), Takeyoshi Sata1), Nobuyuki Yanagihara2)
1)Dept. Anesthe., Occup. & Environ. Hlth., Japan, Sch. Med., 2)Dept. Pharmacol., Univ. Occup. & Environ. Hlth., Japan, Sch. Med., 3)Dept. Occup. Toxicol., Inst. Indust. Ecol. Sci.
Journal of Pharmacological Sciences 121 (suppl) 146-146, 2013.

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P1-50 Effects of free fatty acid receptor GPR40 agonists in mouse models of inflammatory and neuropathic pain

Takashi Kurihara1), Prasanna Karki1),2), Toshihide Asada1), Megumu Yoshimura3), Kazunori Arita2), Atsuro Miyata1)
1)Dept. Pharmacol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 2)Dept. Neurosurgery, Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 3)Grad. Sch. Health Sci., Kumamoto Health Sci. Univ.
Journal of Pharmacological Sciences 121 (suppl) 146-146, 2013.

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P1-51 The effect of acetaminophen on pain-related gene expressions in rat brain

Hiroaki Nakamura, Hiroyuki Inaba, Yuki Ogawa, Noriyuki Monoi, Tetsushi Serizawa, Michiaki Murakoshi
Life Sci. Res. Lab., Res. & Devel. Hq., Lion Corp.
Journal of Pharmacological Sciences 121 (suppl) 146-146, 2013.

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P1-52 External low pH enhances TRPA1-mediated acute pain by hydrogen sulfide

Kenji Takahashi1), Hitomi Ogawa1), Shigeru Saito2), Makoto Tominaga2), Toshio Ohta1)
1)Dept. Vet. Pharmacol., Fac. Agri., Tottori Univ., 2)Div. of Cell Signaling, NIPS
Journal of Pharmacological Sciences 121 (suppl) 146-146, 2013.

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P1-53 Involvement of TRPA1 in Cadmium-induced acute pain in mice

Toshio Ohta1), Saeko Miura1), Kenji Takahashi1), Shigeru Saito2), Kunitoshi Uchida2), Makoto Tominaga1)
1)Dept. Vet. Pharmacol., Fac. Agri., Tottori Univ., 2)Dev. of Cell Signaling, NIPS
Journal of Pharmacological Sciences 121 (suppl) 147-147, 2013.

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P1-54 Transcription factor MafB regulates neuropathic pain development after peripheral nerve injury

Ryu Kawada, Hidetoshi Saitoh, Takahiro Masuda, Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 147-147, 2013.

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P1-55 Role of CCL21 in upregulation of MafB expression in spinal microglia after peripheral nerve injury

Chinami Kojima, Hidetoshi Saitoh, Takahiro Masuda, Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 147-147, 2013.

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P1-56 Role of IRF8 in tactile allodynia of a mouse model of fibromyalgia

Takanori Akagi1), Makoto Tsuda1), Takahiro Masuda1), Hidetoshi Tozaki-Saitoh1), Tomohiko Tamura2), Kazuhide Inoue1)
1)Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2)Dept. Immunol., Grad. Sch. Med., Yokohama City Univ.
Journal of Pharmacological Sciences 121 (suppl) 147-147, 2013.

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P1-57 Astrocyte-derived Thrombospondin-1 in the primary somatosensory cortex plays a key role in Neuropathic Pain

Hideaki Hayashi1), Sun Kwang Kin2), Keisuke Shibata1), Junichi Nabekura2), Schuichi Koizumi1)
1)Dept. Pharmacol., Yamanashi Univ. Sch. Med., 2)NIPS, Division of Homeostatic Development, National Institute for Physiological Sciences
Journal of Pharmacological Sciences 121 (suppl) 148-148, 2013.

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P1-58 Suppression of severe pain and cachexia by inhibiting phosphorylated signal transducers and activator of transcription 3 (pSTAT3) in the nerve invasion (N-inv) murine model of pancreatic cancer

Hidetaka Suzuki1),2), Shuichi Mitsunaga2), Masami Suzuki3), Atsushi Ochiai2), Minoru Narita1)
1)Dept. of Pharmacol., Hoshi Univ. Sch. of Pharm. and Pharmaceut., 2)Pathol. Div., Innovative Med. Res. Ctr., Natl. Cancer Ctr., 3)Div. of Cancer pathophysiology, Natl. Cancer Ctr. Res. Inst.
Journal of Pharmacological Sciences 121 (suppl) 148-148, 2013.

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P1-59 T-lymphocyte infiltration in the spinal dorsal horn and its role in murine tactile allodynia induced by human herpesvirus 1

Atsushi Sasaki, Atsushi Shinoda, Yasushi Kuraishi
Dept. of Applied Pharmacol., Grad. Sch. of Med. and Pharm. Sci., Univ. of Toyama
Journal of Pharmacological Sciences 121 (suppl) 148-148, 2013.

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P1-60 The role of hypothalamic dopaminergic function in feeding behavior

Naomi Yonemochi, Hiroko Ikeda, Chrismawan Ardianto, Yasuna Watanabe, Megumi Ikegami, Junzo Kamei
Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 148-148, 2013.

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P1-61 Saccharin enhances neurite extension in the neuronal cell lines

Yoshikage Muroi, Hiroo Yamashita, Toshiaki Ishii
Dept. Basic Vet Med. Obihiro Univ.
Journal of Pharmacological Sciences 121 (suppl) 149-149, 2013.

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P1-62 Acidic-pH activatable fluorescence probes for monitoring exocytosis dynamics

Daisuke Asanuma1), Yousuke Takaoka2), Shigeyuki Namiki1), Kenji Takikawa1), Mako Kamiya3), Tetsuo Nagano4), Yasuteru Urano3), Kenzo Hirose1)
1)Grad. School of Medicine, The Univ. of Tokyo, 2)Grad. School of Medicine, The Univ. of Tokyo, 3)Grad. School of Engineering, Kyoto Univ., 4)Grad. School of Pharmaceutical Sciences, The Univ. of Tokyo
Journal of Pharmacological Sciences 121 (suppl) 149-149, 2013.

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P1-63 The intracerebral administration of insulin analogue recovers STZ-induced cognitive decline in rats-behavioral experiments

Shozo Kito1), Akiko Shingo2)
1)Chigasaki Tokushu-kai Clinic, 2)Okinaka memorial Inst for Med Res
Journal of Pharmacological Sciences 121 (suppl) 149-149, 2013.

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P1-64 Behavioral deficits in corneal kindled mouse model of epilepsy and the effect of levetiracetam

Rika Ochi1), Katsuya Suemaru2), Kenshi Takechi1), Mamoru Tanaka1), Akihiro Tanaka1), Hiroaki Araki1)
1)Div. Pharmacy, Ehime Univ. Hosp., 2)School of pharmacy, Shujitsu Univ.
Journal of Pharmacological Sciences 121 (suppl) 149-149, 2013.

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P1-65 Clathrin heavy chain CHC22 impairs mice skeletal muscle regeneration

Kazuho Sakamoto1),2), Sachiko Hoshino2), Christene Griffin2), Jorge Torres2), Stephane Camus2), Frances Brodsky2)
1)Dept. Pharmacol., Fukushima Med. Univ. Sch. Med., 2)Dept. Bioengineering Therapeutic Sci., Univ. Calif.
Journal of Pharmacological Sciences 121 (suppl) 150-150, 2013.

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P1-66 Decreased sarcolemmal sialic acid level as a sensitive marker for muscle injury in muscular disorders

Yuko Iwata, Shigeo Wakabayashi
Dept. Mol. Physiol. N.CV.C.
Journal of Pharmacological Sciences 121 (suppl) 150-150, 2013.

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P1-67 The effect of histidine rich glycoprotein on neutrophil chemotaxis

Hidenori Wake1), Shuji Mori2), Hideo K Takahashi3), Keyue Liu1), Kiyoshi Teshigawara1), Masahiro Nishibori1)
1)Dept. Pharmacol., Okayama Univ. Grad. Sch. Med., Dent. & Pharm. Sci., 2)Shujitsu Univ. Sch. Pharm., 3)Dept. Pharmacol., Kinki Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 150-150, 2013.

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P1-68 Elevated plasma factor VIII enhances venous thrombus growth in rabbit

Chihiro Sugita1), Toshihiko Yanagita1), Takayuki Nemoto1), Atsushi Yamashita2), Yunosuke Matsuura2),3), Takashi Iwakiri2),3), Nozomi Okuyama2), Yujiro Asada2), Manabu Murakami1)
1)Dept. Pharmacol., Miyazaki Univ. Sch. Med., 2)Dept. Pathol, Miyazaki Univ Sch. Med., 3)Dept. Internal Med., Miyazaki Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 150-150, 2013.

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P1-69 Regulation of adipocyte differentiatjon by PDZRN3 protein through STAT5b

Takeshi Honda, Aiko Ishii, Makoto Inui
Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 151-151, 2013.

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P1-70 Signaling mechanism on the promotion of skin epithelial cell migration by angiotensin II

Hiroki Sakai, Kenji Matsuura, Takeshi Honda, Yoshie Tanaka, Makoto Inui
Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 151-151, 2013.

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P1-71 Adipocyte-specfic hypoxia-inducible factor-1alpha knockout stimulated GLP-1 and insulin secretions in mice

Yoji Hoshina1),2), Yoshitaka Kihira1), Shuhei Tomita3), Mariko Miyake4), Noriko Yamano1), Yuki Ishizawa1), Keisuke Ishizawa4), Yasumasa Ikeda1), Koichiro Tsuchiya4), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 2)Student Lab., Fac. Med., Univ. Tokushima Grad. Sch., 3)Div. Mol. Pharmacol., Fac. Med., Tottori Univ., 4)Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 151-151, 2013.

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P1-72 Tissue distribution of aquaporin gene expression and changes in the expression of aquaporins in skin with contact dermatitis in the mouse

Hiroyasu Sakai, Ken Sato, Ryoto Sugiyama, Kazuhide Takase, Ara Jo, Akiko Hirosaki, Tomomi Yamada, Yuka Inoue, Tetsuro Shoji, Minoru Narita
Dept. Pharmacol., Hoshi Univ.
Journal of Pharmacological Sciences 121 (suppl) 151-151, 2013.

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P1-73 Regulation of gene expression of chloride channel accessory protein in differentiated epithelial cells

Ryo Hiromatsu1), Mitsutoki Hatta2), Tsuyako Ohkubo2), Ryuji Sakagami1), Jun Yamazaki2)
1)Dept. Odontol., Fukuoka Dent. Coll., 2)Dept. Physiol. Sci. Mol. Biol., Fukuoka Dent. Coll.
Journal of Pharmacological Sciences 121 (suppl) 152-152, 2013.

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P1-74 Analysis of RhoA activity in IGF-I induced hypertrophic myotubes of C2C12 cells

Yusuke Kirimura1), Shuji Ueda1), Minoru Yamanoue1), Takaya Satoh2), Yasuhito Shirai1)
1)Dept. Agrobioscience, Grad. Sch. Agricultural Science, Kobe Univ., 2)Dept. Biological Science, Grad. Sch. Science, Osaka Prefecture Univ.
Journal of Pharmacological Sciences 121 (suppl) 152-152, 2013.

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P1-75 STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein

Hirofumi Kai, Misato Sho, Takashi Sato, Keisuke Chosa, Ruiko Yamakawa, Mary Ann Suico, Tsuyoshi Shuto
Dept of Mol. Med., Grad. Sch. of Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 152-152, 2013.

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P1-76 Exploration of functional mutations of ryanodine receptor in malignant hyperthermia

Toshiko Yamazawa1), Hideto Oyamada2), Takashi Murayama3), Masahide Nakano2), Katsuji Oguchi2), Takashi Sakurai3), Masamitsu Iino4), Shigeru Takemori1)
1)Dept. Molecular Physiol., Jikei Univ. Sch. Med., 2)Dept. Pharmacol., Showa Univ. Sch. Med., 3)Dept. Pharmacol., Juntendo Univ. Sch. Med., 4)Dept. Pharmacol., Grad. Sch. Med. Univ. of Tokyo
Journal of Pharmacological Sciences 121 (suppl) 152-152, 2013.

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P1-77 Protective effects and molecular mechanisms of oligonol in UV-irradiated NIH3T3 cells

Xiaohong Zhang1), Kristina Kurgonaite1), Hiroshi Nishioka1), Hajime Fujii1), Min Yi2)
1)Lab. of Biology & Chemistry, Amino Up Chemical Co., Ltd., 2)Dept. Advanced Medicine, Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 153-153, 2013.

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P1-78 Protein Phosphatase 6 negatively regulates autophagy

Nobuyuki Fujiwara, Takashi Ohama, Koichi Sato
Lab. Vet. Phamacol., Dept. Vet. Med., Yamaguchi Univ.
Journal of Pharmacological Sciences 121 (suppl) 153-153, 2013.

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P1-79 Nicotine- and tar-free cigarette smoke extract induces cell injury via intracellular Ca2+ dependent PKC activation

Tsunehito Higashi, Yosuke Mai, Takahiro Horinouchi, Koji Terada, Chizuru Hatate, Soichi Miwa
Dept. Cellular Pharmacol., Grad. Sch. Med. Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 153-153, 2013.

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P1-80 Vitamin C and its analogue-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes

Mitsutoshi Kimura, Hajime Moteki, Masahiko Ogihara
Dept. Clin. Pharmacol., Fac. Pharm. Sci., Josai. Univ.
Journal of Pharmacological Sciences 121 (suppl) 153-153, 2013.

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P1-81 Protective effects of propofol on LPS-induced apoptosis of hepatocyte in rats

Guo-Gang Feng1), Nobuhisa Kandatsu2), Lei Huang1), Fumio Kondo1), Yoshihiro Fujiwara2), Shoshiro Okada1)
1)Dept. Pharmacol., Aichi Med. Univ. Sch. Med., 2)Dept. Anesth., Aichi Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 154-154, 2013.

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P1-82 Involvement of nitric oxide in proliferation in the neural stem/progenitor cells derived from hippocampal dentate gyrus of adult mice

Kiyokazu Ogita, Masanori Yoneyama, Shigeru Hasebe
Dept. Pharmacol., Setsunan Univ.
Journal of Pharmacological Sciences 121 (suppl) 154-154, 2013.

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P1-83 Modes of action of genes facilitating ischemia-induced VEGF secretion in human adipose-derived mesenchymal stem cells

Mitsutoshi Satoh1), Midori Nakajima1), Tomomi Kuramochi1), Satoshi Yasuda2), Yoji Sato2)
1)Dept. Toxicol. & Pharmacol, Phar. Sci., Toho Univ., 2)Div. of Cell. & Gene Ther. Prod., NIHS.
Journal of Pharmacological Sciences 121 (suppl) 154-154, 2013.

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P1-84 Comparison of caspase-14 and filaggrin expressions between cornified and non-cornified stratified epithelia

Hiroshi Murakami1), Kazuhiko Okamura2), Mitsutoki Hatta3), Sakagami Ryuji1), Jun Yamazaki3)
1)Dept. Odontol., Fukuoka Dent. Coll., 2)Dept. Morphol. Biol., Fukuoka Dental Coll., 3)Dept. Physiol. Sci. Mol. Biol., Fukuoka Dental Coll.
Journal of Pharmacological Sciences 121 (suppl) 154-154, 2013.

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P1-85 Increased seizure susceptibility in the synaptic vesicle protein SV2A mutant rats

Takahiro Okumura1), Shizuka Ishihara1), Ryo Terada1), Saki Shimizu1), Kentaro Tokudome1), Chisato Tomita1), Ryousuke Kitaya1), Tomoya Tanaka1), Naofumi Kunisawa1), Tomoji Mashimo2), Tadao Serikawa2), Masashi Sasa3)
1)Lab. Pharmacol., Osaka Univ. Pharm. Sci., 2)Inst. Lab. Animals, Kyoto Univ. Sch. Med., 3)Nagisa Clinic
Journal of Pharmacological Sciences 121 (suppl) 155-155, 2013.

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P1-86 Hyperexcitability of the hippocampal neurons in the synaptic vesicle protein SV2A mutant rats

Kentaro Tokudome1), Takahiro Okumura1), Saki Shimizu1), Naofumi Kunisawa1), Chisato Tomita1), Ryosuke Kitaya1), Tomoji Mashimo2), Tadao Serikawa2), Masashi Sasa3), Yukihiro Ohno1)
1)Lab. Pharmacol., Osaka Univ. Pharm. Sci., 2)Inst. Lab. Animals, Kyoto Univ. Sch. Med., 3)Nagisa Clinic
Journal of Pharmacological Sciences 121 (suppl) 155-155, 2013.

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P1-87 Infection Experiment Using Infuuenza Virus A

Shigenori Enoki, Katoh Atsuko, Kikuyo Nakaoka, Nanako Imamura, Hiroshi Fujimura, Masakazu Imaizumi, Hiroshi Atai, Katsuhide Nishi
Pharmacol. Dept., Mitsubishi Chemical Medience Cerporation
Journal of Pharmacological Sciences 121 (suppl) 155-155, 2013.

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P1-88 Development of monoclonal antibodies against the extracellular domains of mouse AQP4 and its application to elucidating the disease mechanism of neuromyelitis optica

Yoichiro Abe1), Hiroko Iwanari2), Osamu Arai2), Ramadhanti Julia1), Ping Huang1), Takayuki Miyauchi1), Nobuyoshi Kurihara1), Kaori Mitazaki1), Hiroko Ikeshima-kataoka1), Toshiko Sakihama2), Takao Hamakubo2), Masato Yasui1)
1)Dept. Pharmacol. Keio Univ. Sch. Med., 2)Dept. Mol. Biol. Med., RCAST, Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 155-155, 2013.

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P1-89 The Effect of KANSEI on Animal Model for Non-Alcoholic Steatohepatitis (NASH) in Mice

Souta Ushijima1), Takahumi Oshikata2), Mika Saruwatari1), Namie Beppu1), Seiichi Katayama1), Hiroshi Atai1), Katsuhide Nishi2), Chie Konno3), Takeshi Hirano3), Yoshitake Tatebayashi3), Yasuhiko Nishioka4), Tsukasa Kirimoto4)
1)Mitsubishi Chemical medience corporation, 2)Mitsubishi Chemical medience corporation, 3)Tatebayashi-shokakudo. co., ltd., 4)TAIHO PHARMACEUTICAL CO., LTD.
Journal of Pharmacological Sciences 121 (suppl) 156-156, 2013.

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P1-90 Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improves learning ability by increasing brain-derived neurotrophic factor levels in a SHR. Cg-Leprcp/NDmcr rats

Michio Hashimoto, Takayuki Inoue, Masanori Katakura, Yoko Tanabe, Mamun Abdullsh, Osamu Shido
Dept. Environment. Physiol., Shimane Univ. Facult. Med.
Journal of Pharmacological Sciences 121 (suppl) 156-156, 2013.

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P1-91 Effect of oral challenge with wheat protein in mice systemically sensitized with hydrolyzed wheat protein (HWP)

Takamichi Kitano1), Hirotaka Yamashita1),2), Naoki Inagaki1),2), Hiroyuki Tanaka1),2)
1)Lab. Pharmacol., Dept. Bioactive Mol., Gifu Pharm. Univ., 2)United Grad. Sch. Drug Disc. Med. Inform. Sci., Gifu Univ.
Journal of Pharmacological Sciences 121 (suppl) 156-156, 2013.

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P1-92 Inhibitory effect of 10-Hydroxy-trans-2-decenoic acid (royal jelly acid) on lipopolysaccharide- and interferon-β-induced nitric oxide production

Keita Takahashi1), Tsuyoshi Sugiyama2), Nobuyuki Yanagihara1), Hiroshi Mori2)
1)Dept. Pharmacol., Univ. of Occup. and Environ. Health Japan. Sch. Med., 2)Gifu Pharm. Univ. Lab. Microbiol.
Journal of Pharmacological Sciences 121 (suppl) 156-156, 2013.

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P1-93 Isolation of a novel mitogenic factor from the pedicellariae of the toxopneustid sea urchin, Toxopneustes pileolus

Hideyuki Nakagawa1), Kozue Edo2), Yuri Kotake1), Hitomi Sakai1), Mitsuko Shinohara3), Rie Nishiitsutsuji3), Kiyoshi Ohura3)
1)Dept. of Environmental Symbiosis, Inst. of Socio-Arts and Sci. Univ. of Tokushima Grad. Sch., 2)Dept. of Nutritional Sci., Univ. of Yasuda Women's, 3)Dept. of Pharmacol., Osaka Dental Univ.
Journal of Pharmacological Sciences 121 (suppl) 157-157, 2013.

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P1-94 Sesamin up-regulates LPS-induced expression of heme oxygenase-1 in RAW264.7 macrophage

Takuya Kawakami, Masatoshi Ohnishi, Mizuki Fukunaga, Ayano Shiratsuchi, Atsuko Inoue
Dept. Parmacotherapeut., Fukuyama Univ. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 157-157, 2013.

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P1-95 Reactivity of NSAIDs with Peroxidase: A Classification of NSAIDs

Toshiaki Miura
Hokkaido Pharm. Univ. Sch. Pharmacy
Journal of Pharmacological Sciences 121 (suppl) 157-157, 2013.

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P1-96 Development of Sneeze and Runny Nose Model in Guinea Pigs

Yasuo Nakamura, Souta Ushijima, Kousuke Morizumi, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Mitsubishi Chemical Medience Corporation
Journal of Pharmacological Sciences 121 (suppl) 157-157, 2013.

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P1-97 A Bleomycin-induced Pulmonary Fibrosis Model in Mice

Hiroshi Fujimura, Mikio Mitsuishi, Kousuke Morizumi, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Dept. Pharmacol., Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Ltd.
Journal of Pharmacological Sciences 121 (suppl) 158-158, 2013.

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P1-98 Mast cell-derived prostaglandin D2 suppresses intestinal allergic inflammation

Tatsuro Nakamura1), Takahisa Murata1), Shigeko Matsumoto1), Kosuke Aritake2), Masatoshi Hori1), Yoshihiro Urade2), Hiroshi Ozaki1)
1)Vet. Pharmacol. The Univ. of Tokyo, 2)Mol. Behav. Biol. Osaka Bioscien. Inst.
Journal of Pharmacological Sciences 121 (suppl) 158-158, 2013.

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P1-99 Inflammatory stimulation induces expression of TRPA1 channel to regulate cytokine release

Noriyuki Hatano1), Yuka Itoh2), Hiroka Suzuki1), Yukiko Muraki1), Hidetoshi Hayashi2), Kikuo Onozaki3), Ian Wood4), David Beech4), Katsuhiko Muraki1)
1)Lab. Cellular Pharmacol. Sch. Pharm., Aichi-gakuin Univ., 2)Dept. Drug Metab, Dispos., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 3)Dept. Mol. Health Sci., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 4)Inst. of Membrane and Systems Biol., Garstang Building, Fac. of Biol. Sci., Univ. of Leeds
Journal of Pharmacological Sciences 121 (suppl) 158-158, 2013.

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P1-100 Ameliorative effect of Bacopa monnieri on transient cerebral ischemia- and olfactory bulbectomy-induced cognitive deficits in mice

Kinzo Matsumoto1), Xoan Le Thi1), Hang Pham Thi Nguyet2), Phuong Do Thi2), Hironori Fujiwara1), Michihisa Tohda1), Khoi Nguyen Minh2)
1)Div. Medicinal Pharmacol., Univ. Toyama, Inst. Natural Med., 2)Vietnam Inst. Medicinal Materials
Journal of Pharmacological Sciences 121 (suppl) 158-158, 2013.

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P1-101 Yokukansan improves voluntary activity mediated by serotonin receptor in mice administered with dexamethasone

Hiroyoshi Ogawa1), Rin Okabe1), Kazuki Terada1), Nobuaki Kasai1), Shinya Yamada1), Toru Iizuka2), Nobuo Izumo1)
1)Dept. Clin. Pharmacol., Yokohama Col. Pharm., 2)Lab. Pharmacog., Yokohama Coll. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 159-159, 2013.

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P1-102 Analgesic action of chitosan oligosaccharides

Rie Terasawa, Kazuo Koiso, Norihumi Yonehara
Dept. Dent. Pharmacol., Ohu Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 159-159, 2013.

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P1-103 Molecular basis for the promotion of wound healing by shikonin in an artificial wound healing model with cultured cells

Hiromi Takano-Ohmuro1), Yuhma Miura2), Yuhki Hananoi2), Nozomi Ohuchi2), Lucia Satiko Yoshida1), Hitoshi Endou3), Tomohito Kakegawa2)
1)Fac. Pharmacy & Res. Inst. Pharmaceutical Sci., Musashino Univ., 2)Fac. Pharmaceut. Sci., Josai International Univ., 3)J-Pharma Co., Ltd
Journal of Pharmacological Sciences 121 (suppl) 159-159, 2013.

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P1-104 Label-free, rapid and reliable new cell-based assay for physiological concentration of anti-cancer and anti-metabolic syndrome compounds: evaluation within 1 h

Toshihiro Ona, Junko Shibata
Precision Bio-Engineering Co., Grad. Sch. Biores. Bioenv. Sci.
Journal of Pharmacological Sciences 121 (suppl) 159-159, 2013.

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P1-105 Effect of organotin on glucose transport in human embryonic carcinoma cells

Shigeru Yamada, Yuko Sekino, Yasunari Kanda
Div. Pharmacol., Natl. Inst. Hlth. Sci.
Journal of Pharmacological Sciences 121 (suppl) 160-160, 2013.

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P1-106 Effects of Forskolin on cultured rat embryos

Atsushi Yokoyama1), Masaharu Akita2)
1)Kanagawa Life-sciense Research, 2)Kamakura woman's college
Journal of Pharmacological Sciences 121 (suppl) 160-160, 2013.

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P1-107 Designing of new cytotoxic isoquinolines against human oral squamous cell carcinoma cell lines (Part2)

Mariko Ishihara1), Yoshihiro Uesawa2), Hiroshi Sakagami3)
1)Div. Basic Chem., Meikai Uiv. Sch. Dent., 2)Dept. Clin. Pharmaceut., Meiji Pharm. Univ., 3)Div. Pharm., Meikai Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 160-160, 2013.

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P1-108 QSAR analyses of cytotoxiciy and tumor-specificity of licorice flavonoids by semi-empirical methods

Yoshihiro Uesawa1), Mariko Ishihara2), Hiroshi Sakagami3), Hajime Kagaya1), Hirokazu Ohno4), Masaji Yamamoto4)
1)Dept. Clin. Pharmaceut., Meiji Pharm. Univ., 2)Div. Basic Chem., Meikai Univ. Sch. Dent., 3)Div. Pharmacol., Meikai Univ. Sch. Dent., 4)Maruzen Pharm. Co. Ltd.
Journal of Pharmacological Sciences 121 (suppl) 160-160, 2013.

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P1-109 Possible Biomarkers of Hepatotoxicity due to Ritodrine Treatment

Hiroyoshi Tsuchiya1), Junji Sato3), Hidetoshi Tsuda2), Yoko Fujiwara1), Toshiyuki Yamada3), Akio Fujimura2), Taka-aki Koshimizu1)
1)Dept. Mol. Pharmacol., Jichi Med. Univ., 2)Dept. Clin. Pharmacol., Jichi Med. Univ., 3)Dept. Clin., Lab. Med., Jichi Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 161-161, 2013.

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P1-110 Effects of MRP4 polymorphism on serum uric acid level and uric acid clearance after single administration of trichlormethiazide -a pilot study-

Tatsuya Yoshihara1), Kengo Hayamizu1), Akihiro Nagano1), Masaki Arioka1), Yutaka Kitamura1), Fumi Takahashi2), Hideyuki Ikematsu3), Hisatomi Arima4), Toshiyuki Sasaguri1)
1)Dept. Cli. Pharmacol., Kyushu Univ., 2)Dept. Med. Edu., Kyushu Univ., 3)Center. Med. Innov., Kyushu Univ., 4)Geroge Institute
Journal of Pharmacological Sciences 121 (suppl) 161-161, 2013.

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P1-111 AZT active metabolite impairs mitochondrial quality control system

Takeya Sato2), Ryousuke Nomura1),2), Shigeki Kushimoto1), Teruyuki Yanagisawa2)
1)Emergency center, Tohoku Univ. Hosp., 2)Dept. Molpharm. Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 161-161, 2013.

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P1-112 Effects of ghrelin on survival and cardiac remodeling of dilated cardiomyopathy mice with troponin mutation

Cheng-Kun Du1), Dong-Yun Zhan1), Sachio Morimoto2), Tsuyoshi Akiyama1), Kenji Kangawa1), Mikiyasu Shirai1)
1)Natl. Cerebral. Cardiovasc. Res. Ctr. Inst., 2)Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 161-161, 2013.

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P1-113 Increased excretion of urinary metabolites of prostaglandin D2 in animal models of dilated cardiomyopathy

Shinya Kamauchi, Yuko Iwata, Shigeo Wakabayashi
Dept. of Mol. Physiol., Natl. Cer. Cardiovas. Ctr.
Journal of Pharmacological Sciences 121 (suppl) 162-162, 2013.

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P1-114 Cardioprotective effect of piceatannol against ischemia-reperfusion injury

Fumiaki Nasu1), Shintaro Ono1), Yutaka Matsumoto3), Ikuko Kurita4), Yuko Uchida4), Tatehiko Ito4), Yumi Katano2), Akira Ishihata2)
1)Grad. Yamagata Univ. Sch. Med., 2)Div. Theoretic. Nurse. & Pathophysiol., Yamagata Univ. Sch. Med., 3)Div. Theoretic. Health. & Maturity.,Niigata Univ. Sch. Med., 4)Div. Health Care. Morinaga. & Company. limited.
Journal of Pharmacological Sciences 121 (suppl) 162-162, 2013.

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P1-115 Role of superoxide in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts

Takeshi Koyama1), Masashi Tawa2), Akari Tsubota1), Noriko Yamagishi1), Tatsuya Sawano1), Mamoru Ohkita1), Yasuo Matsumura1)
1)Lab. Pathol. And Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci., 2)Dept. Pharmacol., Shiga Univ. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 162-162, 2013.

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P1-116 Effects of levosimendan on transverse aortic constriction-induced cardiac remodeling in mice

Muneyoshi Okada, Kazuma Seo, Hideyuki Yamawaki, Yukio Hara
Lab. of Vet. Pharmacol., Kitasato Univ.
Journal of Pharmacological Sciences 121 (suppl) 162-162, 2013.

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P1-117 Effects of voluntary exercise on electrical remodeling in DCM model mice

Masami Sugihara1), Fuminori Odagiri1),2), Takeshi Suzuki1),2), Takashi Murayama1), Yuji Nakazato4), Hiroyuki Daida1), Hiroyuki Daida2), Sachio Morimoto3), Nagomi Kurebayashi1)
1)Dept. Pharmacol., Juntendo Univ Sch Med., 2)Dept. Cardiol., Juntendo Univ Sch Med., 3)Dept. Clinical Pharmacol., Fac Med Sci, Kyushu Univ, 4)Dept. Cardiol., Juntendo Univ Sch Med.
Journal of Pharmacological Sciences 121 (suppl) 163-163, 2013.

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P1-118 Pravastatin attenuates cardiac dysfunction induced by lysophosphatidylcholine in isolated rat hearts

Libing Li
Department of Cardiovascular Surgery, Chinese PLA General Hospital
Journal of Pharmacological Sciences 121 (suppl) 163-163, 2013.

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P1-119 Role of endothelium in the vascular response to resveratrol and piceatannol

Shintaro Ono1), Fumiaki Nasu1), Ikuko Kurita3), Yuko Uchida3), Tatehiko Itoh3), Yumi Katano2), Akira Ishihata2)
1)Grad. Yamagata Univ. Sch. Med., 2)Div. Theoretical Nursing and Pathophysiology Yamagata Univ. Sch. Med., 3)Div. Health care. Morinaga & Company. Limited
Journal of Pharmacological Sciences 121 (suppl) 163-163, 2013.

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P1-120 Oligonol inhibited the NADPH oxidase activity and preserved the insulin signal in endothlial cells under diabetic conditions

Hiroki Yokoo, Kumiko Taguchi, Kengo Tomita, Michinori Takashina, Qiang Wang, Lobna.A.Abdelzaher, Yuichi Hattori
Dept. of Mol. Med. Pharmacol., Graduate Sch. of Med. and Pharm., Univ. of Toyama
Journal of Pharmacological Sciences 121 (suppl) 163-163, 2013.

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P1-121 Differences in protease-activated receptor-2 (PAR2)-mediated vasodilation in a rat model of metabolic syndrome with increasing age

Kana Maruyama1), Satomi Kagota1), Hirokazu Wakuda1), John.J.McGuire2), Noriko Yoshikawa3), Kazuki Nakamura3), Masaru Kunitomo3), Kazumasa Shinozuka1)
1)Dept. Pharmacol. II, Mukogawa Women's Univ. Sch. Pharm. Pharmaceuti. Sci., 2)Cardiovasc. Res., Div. Biomed. Sci., Memorial Univ., St.John's, 3)Dept. Pharmacol. I, Mukogawa Women's Univ. Sch. Pharm. Pharmaceuti. Sci.
Journal of Pharmacological Sciences 121 (suppl) 164-164, 2013.

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P1-122 Gap junction-mediated vasodilatation induced by quercetin in rat mesenteric artery

Seiichiro Nishida1), Hiroyasu Satoh2), Katsuharu Tsuchida3)
1)Dongo Hospital, 2)Shitennoji Univ., 3)Dpt. Rational Medicinal Sci., Fac. Pharm. Sci., Doshisya Women's College
Journal of Pharmacological Sciences 121 (suppl) 164-164, 2013.

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P1-123 Effect of Zinc concentration in Mohs'paste on ischemia-induced angiogenesis

Shota Nagano1), Daichi Nagashima1), Maho Taguchi2), Yuki Mizutani1), Takuro Yoda1), Masato Shigeyama2), Nobuo Izumo1)
1)Dept. Clin. Pharmacol., Yokohama Coll Pharm., 2)Center for Clinical Pharm., Yokohama Col. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 164-164, 2013.

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P1-124 Characteristics of acetylcholine-induced hyperpolarization and relaxation in rabbit jugular vein

Junko Kajikuri, Yasushi Shibayama, Ryou Otsuka, Takeo Itoh
Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 164-164, 2013.

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P1-125 Abnormal vascular network formation after cessation of VEGF inhibition in neonatal mouse retina

Akane Morita, Tsutomu Nakahara, Yuki Kurauchi, Asami Mori, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 165-165, 2013.

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P1-126 Investigation of Cell isolation method for automated patch clamping using multiple holes chip approach

Atsushi Ohtsuki1),2), Wataru Motohashi1), Iyuki Namekata1), Hikaru Tanaka1)
1)Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci., 2)Nanion Technologies GmbH
Journal of Pharmacological Sciences 121 (suppl) 165-165, 2013.

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P1-127 In vivo electropharmacological effects of fluvoxamine assessed in the halothane-anesthetized canine model

Yukiko Yamazaki1),2), Yuji Nakamura1), Yoshiyuki Motokawa1), Ken Kitahara1),2), Hiroshi Ohara1),2), Satomi Adachi-Akahane1), Takanori Ikeda2), Junichi Yamazaki2), Hiroshi Yamazaki3), Atsushi Sugiyama1)
1)Dept. Pharmacol., Faculty of Med., Toho Univ., 2)Div. of Cardiovasc. Med., Dept. of Internal Med., Toho Univ. Faculty of Med., 3)Lab. Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical Univ.
Journal of Pharmacological Sciences 121 (suppl) 165-165, 2013.

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P1-128 Electrophysiological characteristics of atrial remodlings in the rat abdominal aortocaval fistula hypertrophy model

Keita Yagi1), Aya Ezawa1), Marie Fukumoto2), Yayoi Tsuneoka2), Shogo Hamaguchi2), Takeshi Hasegawa3), Tetsuo Kuze3), Toshiki Chiba1),3), Mizuki Nada1), Iyuki Namekata2), Hikaru Tanaka2), Akira Takahara1),2)
1)Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci., Toho Univ., 2)Dept. Pharmacol, Fclt. Pharmaceut. Sci., Toho Univ., 3)Fukushima Res. Lab. R&D Dept, Toa Eiyo Ltd.
Journal of Pharmacological Sciences 121 (suppl) 165-165, 2013.

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P1-129 Cibenzoline inhibits Na+/Ca2+ exchange current in cardiac ventricular myocytes of guinea pig

Yasuhide Watanabe1), Tomomi Yamakawa1), Junko Kimura2)
1)Dept. Health Sci, Hamamatsu Univ. Sch. Med., 2)Dept. Pharmacol., Fukushima Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 166-166, 2013.

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P1-130 Facilitation of hERG channel and its clinical relevance

Kazuharu Furutani, Kunichika Tsumoto, I-Shan Chen, Yoshihisa Kurachi
Dept. Pharmacol., Osaka Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 166-166, 2013.

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P1-131 Simulation analysis of short-term desensitization of muscarinic K+ current in the heart

Shingo Murakami, Atsushi Inanobe, Yoshihisa Kurachi
Dept. Pharmacol., Osaka Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 166-166, 2013.

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P1-132 Generation of uric acid in heparinized mouse blood by α-adrenoceptor agonist

Makoto Hosoyamada1), Tamaki Watanabe2), Naoko Tomioka1), Masaru Doshi1), Masao Tsuchiya2)
1)Dept. Human Physiol. Pathol., Pharm-Sci., Teikyo Univ., 2)Dept. Practical Pharmacy, Pharm-Sci., Teikyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 166-166, 2013.

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P1-133 Therapeutic effects of telmisartan against adenine-induced chronic kidney disease

Takahiro Sugiura, Yasushi Hirasawa, Koji Iwata, Nozomi Shimato, Takahito Imaizumi, Jun Imai, Yukari Matsui, Yukiko Kawasaki, Tohru Toyoshi
Nihon. Bioresearch, Inc.
Journal of Pharmacological Sciences 121 (suppl) 167-167, 2013.

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P1-134 Role of the prostaglandin E2 receptor subtype EP1 in cisplatin-induced nephrotoxicity

Fumiaki Kojima1),3), Koh-ichi Yuhki1),3), Hitoshi Kashiwagi1),3), Shima Kumei1),3), Shuh Narumiya2),3), Fumitaka Ushikubi1),3)
1)Dept. Pharmacol., Asahikawa Med. Univ., 2)Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med., 3)CREST, Japan Science and Technology Agency
Journal of Pharmacological Sciences 121 (suppl) 167-167, 2013.

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P1-135 Effect of cyclooxygenase (COX)-2 selective inhibitor on mouse renal interstitial fibrosis

Masahiro Shinohara, Naho Takahashi, Shigeyoshi Honma, Makoto Yoshida
Dept. Pathophysiol., Fac. Pharmacy, Takasaki University of Health and welfare
Journal of Pharmacological Sciences 121 (suppl) 167-167, 2013.

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P1-136 A Sub-Convulsive Dose of Picrotoxin, not Bicuculline, Reverses Diazepam-Induced Hypoglossal Nerve Inhibition in Anesthetized Rabbits

Shinichi Nakamura1),2), Kazuhisa Terao5), Kazuo Sugita6), Shigeki Sasaki6), Akira Kitamura5), Masahiko Suzuki3), Kei Maruyama4)
1)Div. Anesth., JA Kumagaya Gen. Hosp., 2)Div. Anesth., JA Kumagaya Gen. Hosp., 3)Lab. Pharmacol., Sch. Med. Tech. and Health, Fac. Health and Med. Care, Saitama Med. Univ., 4)Dept. Pharmacol., Faculty of Med., Saitama Med. Univ., 5)Dept. Anesth., Saitama Inter. Med. Cent., 6)Div. Pharma., JA Kumagaya Gen. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 167-167, 2013.

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P1-137 Human coagulation factor F-XIa, but not other factors F-IXa and thrombin, has a potent antitussive activity in guinea pigs

Tetsuro Noguchi1), Fumio Soeda1), Tetsuya Sirasaki1), Norio Akaike2), Yushi Ito2), Shintaro Kamei3), Kazuo Takahama1)
1)Dept. Environ. Mol. Health Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ., 2)Research Division for Life Science, Kumamoto Health Science Univ., 3)The Chemo-Sero-Therapeutic Research Institute (Kaketsuken)
Journal of Pharmacological Sciences 121 (suppl) 168-168, 2013.

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P1-138 Increased expression of splicing isoform of zinc transporter ZIP2 in ENaC-overexpressing airway epithelial cells

Shunsuke Kamei, Tsuyoshi Shuto, Chizuru Matsumoto, Yuki Sakaguchi, Hirofumi Nohara, Mary Ann Suico, Hirofumi Kai
Dept. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 168-168, 2013.

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P1-139 Improved method of pulmonary stem/progenitor cells isolation

Kensuke Tanaka1),2), Tetsuo Fujita1),2), Kento Yoshioka1), Masahiko Hagihara3), Sadao Kimura1), Koichiro Tatsumi2), Yoshitoshi Kasuya1)
1)Dept. Biochemistry and Molecular Pharmacol., Grad. School of Med., Chiba Univ., 2)Dept. of Respirol., Grad. School of Med., Chiba Univ. Med., 3)Ube Industries Ltd.
Journal of Pharmacological Sciences 121 (suppl) 168-168, 2013.

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P1-140 Muscarinic regulation of ATP sensitive K+ channels in mouse ileal smooth muscles

Yasuyuki Tanahashi1), Toshihiro Unno2), Hayato Matsuyama2), Takio Kitazawa3), Masahisa Yamada4), Jurgen Wess5), Komori Seiichi2)
1)Lab. Pharmacol., Fac. Life Sci., Kyoto Sangyo Univ., 2)Lab. Pharmacol., Fac. Applied Biol. Sci., Gifu Univ., 3)Dept Vet. Sci., Sch. Vet. Med., Rakuno Gakuen Univ., 4)Common Resources Group, Okinawa Institute of Science and Technology, 5)Lab. Bioorganic Chem., NIDDKD
Journal of Pharmacological Sciences 121 (suppl) 168-168, 2013.

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P1-141 Trypsin induced biphasic contraction and relaxation in the porcine lower esophageal sphincter

Yoshimasa Tanaka1), Eikichi Ihara1), Katsuya Hirano2), Mayumi Hirano2), Kazuhiko Nakamura1), Ryoichi Takayanagi1)
1)Dep. Med. Bioreg. Sci., Grad. Sch. Med. Sci., Kyushu Univ., 2)Div. Mol. Cardiol. Res. Inst. Angiocardiol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 169-169, 2013.

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P1-142 NCX1/NCX2-double heterozygote knockout mice display altered colonic motility in vivo

Yasu-Taka Azuma1), Kazuhiro Nishiyama1), Satomi Kita2), Issei Komuro3), Hidemitsu Nakajima1), Takahiro Iwamoto2), Tadayoshi Takeuchi1)
1)Lab. Vet. Pharmacol., Division of Vet. Sci., Grad. Sch. Life Env. Sci., Osaka Prefecture Univ., 2)Dep. Pharmacol., Facul. Med., Fukuoka Univ., 3)Dep. Cardiovasc. Med., Osaka Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 169-169, 2013.

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P1-143 The effect of histamine on glucagon secretion in αTC1.6 cell

Tadaho Nakamura, Yoshikawa Takeo, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 169-169, 2013.

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P1-144 Effects of Bezafibrate in nonalcoholic steatohepatitis rat model

Yukari Hoshina, Yasushi Hirasawa, Yukiko Kawasaki, Takahiro Sugiura, Takahito Imaizumi, Jun Imai, Tohru Toyoshi, Kohei Kyuki
Nihon Bioresearch Inc.
Journal of Pharmacological Sciences 121 (suppl) 169-169, 2013.

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P1-145 Ca2+-influx induced by activation of Gq-coupled alpha1B adrenergic receptor in human osteoblast

Daisuke Kodama, Akifumi Togari
Dept. Pharmacol., Aichi-Gakuin Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 170-170, 2013.

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P1-146 The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osteocalcin and Osterix

Hiroyuki Fujita, Eiichi Hinoi, Yukio Yoneda
lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech.
Journal of Pharmacological Sciences 121 (suppl) 170-170, 2013.

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P1-147 Up-regulation mechanisms of endosomal/lysosomal proteins during osteoblast differentiation

Erika Yoneshima1), Kuniaki Okamoto1), Eiko Sakai1), Noriaki Yoshida2), Takayuki Tsukuba1)
1)Div. Oral Pathopharmacol., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2)Div. Orthodont. Biomed. Engineen., Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 121 (suppl) 170-170, 2013.

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P1-148 PTH enhances the osteoblast damage induced by zoledronate

Masamichi Tajima
Div. Pharmacol., Dept. Diagnostic and Therapeutic Sciences, Meikai Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 170-170, 2013.

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P1-149 Effect of benzo[b]furan derivative, MU-314, on bone resorption induced by LPS

Atsuhiro Funamoto1), Yukiko Ishibashi2), Sho Hirano1), Ryo Fukuyama3), Yasushi Kodama4), Yoshitaka Oishi5), Mitsugu Fujita3), Nobuo Izumo1)
1)Dept. Clin. Pharmacol., Yokohama Col. Pharm., 2)Dept. Syn. Org. Chem., Yokohama Col. Pharm., 3)Lab. Pharmacol., Pharm. Sci., Hiroshima Int. Univ., 4)Lab. Clinicopahol. Therap., Pharm. Sci., Hiroshima Int. Univ., 5)Sch. Pharm. Sci., Doshisya Women's Col. of Lib. Arts
Journal of Pharmacological Sciences 121 (suppl) 171-171, 2013.

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P1-150 The inhibitory mechanism of eugenol on TRPV1 channel

Takashi Yoshida1), Kaori Takahashi2), Takashi Kikuchi1), Minoru Wakamori1)
1)Div. Mol. Pharmacol. and Cell Biophys., Dept. Oral. Biol, Tohoku univ. Grad. Sch. Dent., 2)Tohoku Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 171-171, 2013.

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P1-151 Potent activation of TRPA1 channel by NADPH oxidase inhibitors

Katsuhiko Muraki1), Hiroka Suzuki1), Noriyuki Hatano1), Yukiko Muraki1), Yuka Itoh2), Hidetoshi Hayashi2), Kikuo Onozaki3)
1)Lab. Cellular Pharmacol., Aichi-gakuin Univ., Sch. Pharm., 2)Dept., Drug Metab., Disp., Grad. Sch., Pharmaceut., Sci., Nagoya City Univ., 3)Dept., Mol., Health Sci., Grad., Sch., Pharmaceut., Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 171-171, 2013.

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P1-152 COX-2 selective inhibitor inhibits osteoclast differentiation

Kakei Ryu1), Hitoshi Amano2), Shinichi Iwai1), Haruka Emori1), Shoji Yamada2), Katsuji Oguchi1)
1)Dept. Pharmacol., Showa Univ. Sch. Med., 2)Dept. Pharmacol., Showa Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 171-171, 2013.

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P1-153 The effect of prostaglandin H synthase on osteoclast differentiation

Akiko Karakawa, Hitoshi Amano, Shoji Yamada
Dept. Pharmacol., Showa Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 172-172, 2013.

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P1-154 Electrochemical property of the cochlear lateral wall crucial for inner ear function

Takamasa Yoshida1),2), Fumiaki Nin1), Naoko Adachi3), Soichiro Yamaguchi4), Yoshihisa Kurachi5), Hiroshi Hibino1)
1)Dept Mol Physiol, Niigata Univ Med Sch, 2)Dept Otolaryngol, Grad Sch Med, Kyushu Univ, 3)Dept Otolaryngol, Kyoto Pref Sch Med, 4)Lab Pharmacol, Dept Biomed Sci, Grad Sch Vet Med, Hokkaido Univ, 5)Dept Pharmacol Grad Sch Med, Osaka Univ
Journal of Pharmacological Sciences 121 (suppl) 172-172, 2013.

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P1-155 The spatial pattern of cochlear amplification

Fumiaki Nin1),2), Jonathan Fisher2), Tobias Reichenbach2), Revathy Uthaiah2), James Hudspeth2)
1)Dept. Physiol. II, Niigata Univ. Sch. Med., 2)Rockefeller University
Journal of Pharmacological Sciences 121 (suppl) 172-172, 2013.

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P1-156 The inhibition for cell migration and invasion in oral cavity cancers by (-)-epigallocatechin-3-gallate

Shunya Egawa1), Shinichi Iwai2), Takeshi Hayashi1), Katsuji Oguchi1)
1)Dept. Pharmacol. Showa Univ. Sch. Med., 2)Department of Healthcare and Regulatory Sciences School of Pharmacy, Showa University
Journal of Pharmacological Sciences 121 (suppl) 172-172, 2013.

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P2-1 Resveratrol has biphasic effect on noradrenaline transporter function

Yumiko Toyohira1), Go Obara1),2), Hirohide Inagaki1), Keita Takahashi1), Kojirou Takahashi3), Nobuyuki Yanagihara1)
1)Dept. Pharmacol., Univ. Occup. & Environ. Hlth., Sch. Med., 2)Dept. Anesth., Univ. Occup. & Environ. Hlth., Sch. Med., 3)Dept. Hospital Pharmacy, Univ. Occup. & Environ. Hlth.
Journal of Pharmacological Sciences 121 (suppl) 173-173, 2013.

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P2-2 Mutation associated with autism modifies RIMS3-mediated modulation of voltage-dependent Ca2+ channels

Yoshinori Takada1), Mitsuru Hirano1), Shigeki Kiyonaka1),2), Yasuo Mori1),2)
1)Dept. Synthet. Chem. & Biol. Chem., Grad. Sch. Engn., Kyoto Univ., 2)Dept. Technol. & Ecol., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 173-173, 2013.

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P2-3 Functional coupling between muscarinic acetylcholine receptors and heterotrimeric G-proteins in rat brain membranes

Yuji Odagaki, Masakazu Kinoshita, Ryoichi Toyoshima
Dept. Psychiat., Saitama Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 173-173, 2013.

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P2-4 Development of high-performance glutamate optical sensor for visualizing synaptic transmission

Kenji Takikawa, Shigeyuki Namiki, Hirokazu Sakamoto, Testuro Ariyoshi, Naoya Kinpara, Daisuke Asanuma, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 173-173, 2013.

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P2-5 Development and screening of novel delta opioid receptor-specific agonists with a label-free, cell-impedance-based CellKey(TM) system

Akinobu Yokoyama1),2), Yuka Sudo2), Kanako Miyano2), Masami Suzuki2), Seiji Shiraishi2), Shigeto Hirayama3), Kohei Hayashida3), Hideaki Fujii3), Junichi Sakai4), Takashi Kanda4), Eriko Nakata4), Hiroshi Nagase4), Yoshikazu Higami1), Yasuhito Uezono2)
1)Dept. Mol. Pathol. Metab. Dis., Faculty of Pharmaceut. Sci., Tokyo Univ. Sci., 2)Div. Cancer Pathophysiol., NCCRI, 3)Dept. Medicinal Chem. Kitasato Univ. Sch. Pharmaceut. Sci., 4)Research Laboratories, Nippon Chemiphar Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 174-174, 2013.

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P2-6 Effects of cannabinoid CB1 receptor activation on the neuronal responses in the mouse amygdala analyzed by voltage-sensitive dye imaging

Kojiro Hara1),2), Tomomi Fujieda1),3), Tomohiko Irie1), Hideki Miwa4),5), Jun-ichiro Oka2), Tomoaki Shirao3), Ruri Kikura-Hanajiri6), Yukihiro Goda6), Yuko Sekino1)
1)Div. Pharmacol., NIHS, 2)Fac. Pharm. Sci., Tokyo Univ. Sci., 3)Dept. Neurobiol. and Behav., Gunma Univ., Grad. Sch. Med., 4)Dept. Denet. and Behav. Neurosci., Gunma Univ., Grad. Sch. Med., 5)JST, CREST, 6)Div. Pharmacog. Phytochem. and Narcotics, NIHS
Journal of Pharmacological Sciences 121 (suppl) 174-174, 2013.

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P2-7 Experience-dependent postsynaptic inositol 1,4,5-trisphosphate signaling regulates presynaptic functions in the barrel cortex

Jun Kubota, Kazunori Kanemaru, Yohei Okubo, Masamitsu Iino
Dept. of Pharmacol., Grad. Sch. of Med., Univ. of Tokyo
Journal of Pharmacological Sciences 121 (suppl) 174-174, 2013.

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P2-8 Adenosine-mediated inhibition of excitatory transmission during ischemia at different temperatures in the hippocampus

Masahito Kawamura
Dept. Pharmacol., Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 174-174, 2013.

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P2-9 C-TYPE NATRIURETIC PEPTIDE MODULATES THE PERMEABILITY OF BLOOD-BRAIN BARRIER

Manoj Bohara1),2), Yuki Kambe1), Takashi Kurihara1), Hiroshi Tokimura2), Kazunori Arita2), Atsuro Miyata1)
1)Dept. Pharmacol., Kagoshima Univ. Grad. Sch. Med. Dent. Sci., 2)Dept. Neurosurgery Kagoshima Univ. Grad. Sch. Med. Dent. Sci.
Journal of Pharmacological Sciences 121 (suppl) 175-175, 2013.

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P2-10 Inhibitory effects of new synthesized biguanide derivatives with pyrazine and alkyl groups to both NMDAR and ASIC1a activities

Takashi Masuko1), Muneharu Miyake2), Toyofumi Suzuki3), Kazuo Tomono3),4), Kuniko Kusama-Eguchi4), Yasuo Kizawa1), Tadashi Kusama1)
1)Lab. Physiol. and Anat., Nihon Univ. Sch. Pharm., 2)Lab. Organ., Nihon Univ. Sch. Pharm., 3)Lab. Pharmaceutics, Nihon Univ. Sch. Pharm., 4)Lab. Biochem., Nihon Univ. Sch. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 175-175, 2013.

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P2-11 Neuroprotective effects of propofol on ER stress mediated-apoptosis in neuroblastoma SH-SY5Y cells

Ai Nakajima, Mayumi Tsuji, Manami Inagaki, Katsuji Oguchi
Dept. Pharmacol., Showa Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 175-175, 2013.

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P2-12 Endoplasmic reticulum stress might regulate the neuronal development via ubiquitin ligase HRD1

Koichi Kawada1), Masayuki Kaneko1),3), Ryo Saito1), Yasuyuki Nomura2), Yasunobu Okuma1)
1)Dept. Pharmacol., Chiba Inst. Sci., 2)Lab. Pharmacotherapeutics, Yokohama Col. Pharm., 3)Lab. Med. Therap. and Mol. Therap., Gifu Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 175-175, 2013.

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P2-13 Effect of estradiol on neurite outgrowth of PC12 cells

Hikari Chiba1), Shota Mochizuki1), Kazuki Terada1), Takahiro Tsuchiya1), Tomomi Morikawa2), Takayuki Manabe2), Nobuo Izumo1)
1)Dept. Clin. Pharmacol., Yokohama Col. Pharm., 2)Div. Gene Exp. Mech., Ins. Comp. Med. Sci., Fujita Health Univ.
Journal of Pharmacological Sciences 121 (suppl) 176-176, 2013.

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P2-14 Proton-induced membrane currents in rat trigeminal mesencephalic nucleus neurons

Michiko Nakamura, Il-Sung Jang
Dept. Dental Phamacol., Kyungpook Natl. Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 176-176, 2013.

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P2-15 Polyl:C impairs neurite outgrowth through follistatin like-1

Shinnosuke Yamada, Taku Nagai, Daisuke Ibi, Kiyofumi Yamada
Dept. Neuropsychopharmacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 176-176, 2013.

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P2-16 IRF1 plays a part in IRF8- induced IL-1β expression in reactive microglia

Shosuke Iwamoto1), Takahiro Masuda1), Nao Nishimoto1), Tomohiko Tamura2), Makoto Tsuda1), Kazuhide Inoue1)
1)Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2)Dept. Immunol., Grad. Sch. Med., Yokohama City Univ.
Journal of Pharmacological Sciences 121 (suppl) 176-176, 2013.

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P2-17 Abnormality of clock gene Per1 occurs in the spinal cord of mice with peripheral neuropathic pain

Tatsuhiko Sugimoto, Norimitsu Morioka, Kazue Hisaoka-Nakashima, Yoshihiro Nakata
Dept. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Health. Sci.
Journal of Pharmacological Sciences 121 (suppl) 177-177, 2013.

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P2-18 IRF8-deficient microglia impairs ATP-induced chemotaxis

Nao Nishimoto1), Takahiro Masuda1), Daisuke Tomiyama1), Ryohei Yoshimaga1), Tomohiko Tamura2), Hidetoshi Saitoh1), Makoto Tsuda1), Kazuhide Inoue1)
1)Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2)Dept. Immunol., Grad. Sch. Med., Yokohama City Univ.
Journal of Pharmacological Sciences 121 (suppl) 177-177, 2013.

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P2-19 Osteopontin has a functional role for astrocyte activation in cultured cells and injured mouse brain

Hiroko Ikeshima-Kataoka1),2), Sayaka Inui1), Masato Yasui1)
1)Dept. Pharmacol. & Neurosci., Keio Univ. Sch. Med., 2)Faculty of Science & Engneering, Waseda Univ.
Journal of Pharmacological Sciences 121 (suppl) 177-177, 2013.

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P2-20 Lotus root extract induces BDNF gene transcription through HO-1 expression in C6 glioma cells

Kyoji Morita1), Naoyoshi Nishibori2), Mi-Sook Lee3), Song Her4)
1)Lab. Neuropharmacol., Dept. Nursing, Shikoku Univ Sch Hlth Sci, 2)Lab. Cell Biol., Dept. Food Sci. Nutr., Shikoku Junior Col., 3)Div. Bio-Imaging, Korea Basic Sci. Inst., 4)Div. Bio-Imaging, Korea Basic Sci. Instit.
Journal of Pharmacological Sciences 121 (suppl) 177-177, 2013.

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P2-21 Dopamine attenuates LPS-induced expression of cytokines through the inhibition of microtubule-dependent nuclear transport of NF-κB p65 in microglial cells

Yuta Sugino, Yasuhiro Yoshioka, Takuma Nishizawa, Yoshiko Wada, Shougo Kotera, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.
Journal of Pharmacological Sciences 121 (suppl) 178-178, 2013.

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P2-22 Simulation analysis of K+ buffering in astrocyte

Shingo Murakami, Yoshihisa Kurachi
Dept. Pharmacol., Osaka Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 178-178, 2013.

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P2-23 Attenuation of cold injury-induced brain edema formation by endothelin ETB antagonists in mice

Shotaro Michinaga, Marina Nagase, Daisuke Yamanaka, Emi Matsuyama, Yutaka Koyama
Dept. Pharmacol, Osaka-ohtani Uni. Sch. Phrm.
Journal of Pharmacological Sciences 121 (suppl) 178-178, 2013.

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P2-24 Large-scale network analysis of glial calcium activities

Sekiko Ujita, Akiko Asada, Norio Matsuki, Yuji Ikegaya
Lab Chem Pharmacol, Grad Sch Pharm Sci, Univ Tokyo
Journal of Pharmacological Sciences 121 (suppl) 178-178, 2013.

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P2-25 Gbetagamma mediated signaling pathway is partially involved in the neurite outgrowth via GPR3

Shigeru Tanaka, Tatsuhiro Miyagi, Izumi Hide, Takahiro Seki, Norio Sakai
Dept. Mol. Pharmacol. Neurosci., Hiroshima Univ. Grad. Sch. Biomed. & Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 179-179, 2013.

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P2-26 Centrally administered prostaglandin E2-glycerol ester activates central sympathetic outflow by brain prostanoid EP3 receptor-mediated mechanisms in rats

Takahiro Shimizu, Masashi Kuriyama, Ryotaro Nagashima, Kenjiro Tanaka, Kumiko Nakamura, Keisuke Taniuchi, Kunihiko Yokotani
Dept. Pharmacol., Sch. of Medicine, Kochi Univ.
Journal of Pharmacological Sciences 121 (suppl) 179-179, 2013.

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P2-27 Centrally administered hemoglobin-derived peptide RVD-hemopressin inhibits bombesin-induced central activation of adrenomedullary outflow by brain cannabinoid CB1 receptor-mediated mechanisms in rats

Kumiko Nakamura, Takahiro Shimizu, Kenjiro Tanaka, Kunihiko Yokotani
Dept. Pharmacol., Sch. of Medicine, Kochi Univ.
Journal of Pharmacological Sciences 121 (suppl) 179-179, 2013.

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P2-28 Involvement of MARCKS signaling pathway in cytotoxicity induced by methylmercury

Mitsuya Shiraishi1), Makoto Hangai1), Masanori Sasaki2), Atsushi Miyamoto1)
1)Dept. Vet. Pharmacol., Kagoshima Univ., 2)Dept. Basic Med. Sci., Natl. Inst. Minamata Dis.
Journal of Pharmacological Sciences 121 (suppl) 179-179, 2013.

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P2-29 The intracerebral administration of insulin analogue recovers STZ-induced morphological changes in the hippocampus

Akiko Shingo1), Shozo Kito2), Toshio Murase1)
1)Okinaka Memorial Inst for Med Res, 2)Chigasaki Tokushu-kai Clinic
Journal of Pharmacological Sciences 121 (suppl) 180-180, 2013.

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P2-30 Effects of Crude Drug Containing Japanese Angelica Root, Cnidium Rhizome, Peony Root and Rehmannia Root on Spatial Learning Disability Induced by β-amyloid Oligomers in Rats

Akiko Pawlak1), Tomomi Ogawa1), Hiroyasu Murasawa1), Kyoko Matsuzawa1), Mie Nakamura1), Kohei Kyuki1), Yoshinao Takahashi2), Toru Takahashi2), Kunio Takahashi2)
1)Nihon Bioresearch Inc., 2)Zaiseido Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 180-180, 2013.

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P2-31 Involvement of membrane-associated estrogen receptor GPR30 in the object recognition memory in Alzheimer's disease mouse models

Takashi Kubota, Hiroshi Matsumoto, Yutaka Kirino
Lab. Neurobiophysics, Kagawa Sch. Pharm. Sci., Tokushima Bunri Univ.
Journal of Pharmacological Sciences 121 (suppl) 180-180, 2013.

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P2-32 J147, a novel neuroprotective compound, promotes the induction of hippocampal long-term potentiation

Tatsuhiro Akaishi1), Pamela Maher2), David Schubert2), Kazuho Abe1)
1)Lab. Pharmacol., Fac. Pharm., Musashino Univ., 2)Cell. Neurobiol. Lab., Salk Inst.
Journal of Pharmacological Sciences 121 (suppl) 180-180, 2013.

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P2-33 Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces oxidative stress in SAMP8 mice

Akira Nakajima1), Yuki Aoyama1), Nguyen Thuy-Ty Lan2), Shin Eun-Joo2), Kim Hyoung-Chun2), Yamada Shinnosuke1), Tsuyoshi Nakai1), Taku Nagai1), Akihito Yokosuka3), Yoshihiro Mimaki3), Yasushi Ohizumi4),5),6), Kiyofumi Yamada1)
1)Dept. Neuropsychopharmacology and Hospital Pharmacy, Nagoya Univ. Grad. Sch. Med., 2)College of Pharmacy, Kangwon National University, 3)Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 4)Graduate School of Pharmaceutical Sciences, University of Shizuoka, 5)Yokohama College of Pharmacy, 6)Graduate School of Engineering, Tohoku University
Journal of Pharmacological Sciences 121 (suppl) 181-181, 2013.

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P2-34 The effect of anti-HMGB1 antibody on pilocarpine-induced epilepsy in mice

Katsuyaku Ryu, Li Fu, Hidenori Wake, Kiyoshi Teshigawara, Masahiro Nishibori
Dept. Pharmacol., Okayama Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 181-181, 2013.

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P2-35 Increased seizure susceptibility in a mouse with diacylglycerol kinase β deficiency

Mitsue Ishisaka1), Kazuhiro Tsuruma1), Masamitsu Shimazawa1), Yasuhito Shirai2), Naoaki Saito3), Hideaki Hara1)
1)Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ., 2)Applied Chemistry in Bioscience, Graduate School of Agriculture, Kobe Univ., 3)Biosignal Research Center, Kobe Univ.
Journal of Pharmacological Sciences 121 (suppl) 181-181, 2013.

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P2-36 SHATI.NAT8L regulates neurite outgrowth via microtubule stabilization

Miki Ikami
Dept. Chem. Pharmacol., Fac. Pharmaceu. Sci., Meijo Univ.
Journal of Pharmacological Sciences 121 (suppl) 181-181, 2013.

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P2-37 Prenatal treatment with phencyclidine induces impairment of the GABAergic neuron in the prefrontal cortex

Mika Oki
Dept. Chem. Pharmacol., Fac. Pharmaceu. Sci., Meijo Univ.
Journal of Pharmacological Sciences 121 (suppl) 182-182, 2013.

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P2-38 Age-related changes of neurodegeneration in the hippocampus of the Cl-pump 55 kDa subunit(CIP55)-null mice

Kaori Kitagawa, Chiyoko Inagaki, Tomoyuki Nakamura
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 182-182, 2013.

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P2-39 Effect of a modulator of the oxidized form of DJ-1 against nigrostriatal dopaminergic degeneration in rotenone-treated mice

Masatoshi Inden1), Yoshihisa Kitamura2), Kazuyuki Takata2), Eishi Ashihara2), Kanji Yoshimoto3), Hiroyoshi Ariga4)
1)Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ., 2)Dept. Clin. Transl. Physiol., Kyoto Pharm. Univ., 3)Dept. Leg. Med., Kyoto Pref. Univ., 4)Dept. Mol. Biol. Lab., Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 182-182, 2013.

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P2-40 Effect of a modulator of the oxidized form of DJ-1 against nigrostriatal dopaminergic degeneration in 6-hydroxydopamine-injected rats

Yoshihisa Kitamura1), Masatoshi Inden2), Kazuyuki Takata1), Eishi Ashihara1), Kanji Yoshimoto3), Hiroyoshi Ariga4)
1)Dept. Clin. Transl. Physiol., Kyoto Pharm. Univ., 2)Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ., 3)Dept. Leg. Med., Kyoto Pref. Univ., 4)Dept. Mol. Biol. Lab., Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 182-182, 2013.

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P2-41 Effects of dexamethasone and retinoic acid receptor agonist Am80 on acute inflammation following intracerebral hemorrhage in mice

Hideaki Matsushita1),2), Masanori Hijioka1), Hayato Ishibashi1), Akinori Hisatsune1), Yoichiro Isohama1), Koichi syudo3), Hiroshi Katsuki1)
1)Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci. Kumamoto Univ., 2)JSPS Research Fellow, 3)Res. Fdn. ITSUU Lab.
Journal of Pharmacological Sciences 121 (suppl) 183-183, 2013.

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P2-42 Sphingolipid analogues, FTY720 and KRP203, are novel regulators for amyloid-beta production

Nobumasa Takasugi1),2),3), Tomoki Sasaki2), Taisuke Tomita2), Takeshi Iwatsubo2),3)
1)Dept. Pharmacol., Juntendo Univ. Sch. Med., 2)Dept. Neuropath and Neurosci., Tokyo Univ. Sch Pharma Sci., 3)Dept. Neuropath., Tokyo Univ. Sch Med.
Journal of Pharmacological Sciences 121 (suppl) 183-183, 2013.

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P2-43 Peripheral inflammation caused neurodegeneration in the central nerve system

Sachiko Tanaka, Shinichiro Sakatsume, Satoshi Numazawa
Dept. Biochem. Toxicol., Showa Univ. Sch. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 183-183, 2013.

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P2-44 Opioid receptor antagonists attenuate methamphetamine-induced stereotypical behavior in mice

Nobue Kitanaka1), Junichi Kitanaka1), Tatsuo Sawai1), Yuko Fukushima1), Koh-ichi Tanaka2), Tomohiro Tatsuta3), Yoshio Morita4), Nobuyoshi Nishiyama2), Motohiko Takemura1)
1)Dept. Pharmacol., Hyogo Col. Med., 2)Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Hlth. Sci., 3)Ibogawa Hosp., 4)Fac. Nursing, Baika Women's Univ.
Journal of Pharmacological Sciences 121 (suppl) 183-183, 2013.

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P2-45 Low-dose methylphenidate improves attention-deficit hyperactivity disorder-like behaviors in spontaneously hypertensive rats

Yuki Kishikawa1),3), Yukie Kawahara1), Makiko Yamada1), Masaru Ishimatsu2), Akinori Nishi1)
1)Dept. of Pharmacol., Kurume Univ. Sch. Med., 2)Dept. of Physiol., Kurume Univ. Sch. Med., 3)Dept. of PT,YIC Reha. Col.
Journal of Pharmacological Sciences 121 (suppl) 184-184, 2013.

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P2-46 Behavio-pharmacological studies on the mechanism of a novel antipsychotic-like action of tipepidine in mice

Ikutaro Honda, Risa Miki, Ryota Hamasaki, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Env. Mol. Health. Sci. Kumamoto Univ. Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 184-184, 2013.

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P2-47 Potentiation of extrapyramidal side effects by antidementia agents and its modulation by the serotonergic system

Saki Shimizu, Yuto Mizuguchi, Akira Sobue, Mai Fuziwara, Tomoki Morimoto, Tomoya Kizu, Syoko Minamimoto, Saki Andatsu, Kentaro Tokudome, Ayaka Tatara, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 184-184, 2013.

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P2-48 Pharmacological property of AD-6048, a primary metabolite of the novel antipsychotic blonanserin

Ayaka Tatara, Saki Shimizu, Atushi Masui, Shoko Minamimoto, Yuto Mizuguchi, Midori Ochiai, Yusuke Mizobe, Miyuki Tamura, Yoshiko Kawai, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 184-184, 2013.

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P2-49 Blood-brain barrier leakage is transiently induced by activity-dependent excessive nitric oxide production

Kouichi Itoh1), Sonoko Danjo1),2), Yasuhiro Ishihara3), Masatomo Watanabe1), Yu Nakamura2)
1)Lab. Brain Sci., Kagawa Sch. Pharm. Sci., Tokushima Bunri Univ., 2)Dept. Neuropsychiatry, Kagawa Univ. Sch. Med., 3)Lab. Mol. Brain Sci, Grad Sch Int Arts & Sci, Hiroshima Univ.
Journal of Pharmacological Sciences 121 (suppl) 185-185, 2013.

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P2-50 The effects of sex and estrous cycle on behavior and biochemical changes in neonatal ventral hippocampal lesion

Hiroshi Onogi1),2),4), Osamu Nakagawasai2), Wataru Nemoto2), Akira Oba2),3), Tsuneaki Kikuchi4), Koichi Tan-No2), Takeshi Tadano5)
1)Faculty of Health Science, Tohoku Fukushi Univ., 2)Dept., Pharmacol., Tohoku Pharmaceutical Univ., 3)Osaki Citizen Hospital, 4)Tohoku Fukushi Univ., Sendan Hospital, 5)Environmental Health Sci., Graduate Sch. Med. Science, Kanazawa Univ.
Journal of Pharmacological Sciences 121 (suppl) 185-185, 2013.

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P2-51 Comparative gene expression analysis of the amygdalae of juvenile rats exposed to valproic acid at prenatal and postnatal stages

Kaoru Sato1), Atsuko Katayama1), Akihiko Monma2), Toru Moriguchi2), Yuko Sekino1)
1)Div. Pharmacol., NIHS, 2)Dept. Food Life Sci., Azabu Univ.
Journal of Pharmacological Sciences 121 (suppl) 185-185, 2013.

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P2-52 Chronic stress induce prolonged depression-like behavior in mice

Narumi Hashikawa1), Yusuke Sakamoto1), Ayaka Sawada1), Hitomi Sasaki1), Hikari Hamamoto1), Youko Ochiai2), Naoya Hashikawa1)
1)Dept. Life Sci., Grad. Sci., Okayama Univ. Sci., 2)Dept. Anes. ICM, Kawasaki Med. Sch.
Journal of Pharmacological Sciences 121 (suppl) 185-185, 2013.

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P2-53 NOX1/NADPH oxidase is involved in the stress-induced anxiety-like behavior

Masakazu Ibi, Kuniharu Matsuno, Hirosuke Uchimaki, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Prefectual Univ. Med.
Journal of Pharmacological Sciences 121 (suppl) 186-186, 2013.

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P2-54 Role of BDNF/TrkB signaling in antidepressant effects of an mGlu2/3 receptor antagonist

Kenichi Fukumoto, Hiroyuki Koike, Michihiko Iijima, Shigeyuki Chaki
Discov. Pharmacol. I, Mol. Func. Pharmacol. Labs., Taisho Pharmaceutical Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 186-186, 2013.

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P2-55 Effects of chronic treatment with ACTH4-10 on the expression of depressive-like symptoms in rats

Toshihiro Yasumori1), Norifumi Shimizu1), Nobuo Izumo2), Chiaki Hara1), Minehiro Moriyama1)
1)Dept. Pharmacol., Daiichi Univ. Pharm., 2)Dept. Clin. Pharmacol., Yokohama Col. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 186-186, 2013.

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P2-56 Toll-like receptor 7-mediated enhancement of depressive-like behavior in mice

Yasunori Kubo, Yoshiki Yanagawa, Machiko Matsumoto, Sachiko Hiraide, Hiroko Togashi
Dept. Phamacol., Fac. of Pharm. Sci., Health Sci., Univ. of Hokkaido
Journal of Pharmacological Sciences 121 (suppl) 186-186, 2013.

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P2-57 Possible involvement of the serotonergic system in the gender difference underlying emotional regulation

Sumitaka Inoue1), Machiko Matsumoto1), Hiroki Shikanai1), Yoshiki Yangawa1), Sachiko Hiraide1), Yasuhiro Saito1), Mitsuhiro Yoshioka2), Keiichi Shimamura1), Hiroko Togashi1)
1)Dept. Pharmacol., Fac, of Pharm. Sci., Health Sci. Univ. of Hokkaido, 2)Dept. Neuropharmcol., Hokkaido Univ. Grad. sch. of Med.
Journal of Pharmacological Sciences 121 (suppl) 187-187, 2013.

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P2-58 Injury site related sensory nerve response and effect of analgesic in rat model of lumbar canal stenosis

Kazuhisa Minami1), Ryuta Tamano1), Hiroshi Oyama2), Shunji Shinohara1)
1)Pain & Neurology., Med. Res. Lab., SHIONOGI, 2)SIC, Innov. Drug Discov. Res. Lab., SHIONOGI
Journal of Pharmacological Sciences 121 (suppl) 187-187, 2013.

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P2-59 Effect of oxidized galectin-1 on neuropatic pain in mice

Norihumi Yonehara1), Rie Terasawa1), Yuichi Koike2), Naomasa Yamamoto3), Toshihiko Kadoya4)
1)Dept. Dent. Pharmacol., Ohu Univ. Sch. Dent., 2)Dept. Drug Metab. and Clini. Pharmacokinetics., Ohu Univ. Sch. Pharm., 3)Dept. Biochem., Ohu Univ. Sch. Pharm., 4)Dept. Biotechnol., Maebashi Inst. of Tech. Technol.
Journal of Pharmacological Sciences 121 (suppl) 187-187, 2013.

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P2-60 Analgesic effects of pregabalin and paroxetine in a neuropathic pain model of cynomolgus monkeys by single and combination dosing

Masahiko Iino, Mitsuru Hoshino, Atsushi Fujiwara, Yoshio Wakasa
Research Administration Dept. Ina Research Inc.
Journal of Pharmacological Sciences 121 (suppl) 187-187, 2013.

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P2-61 Effect of paclitaxel on transient receptor potential vanilloid 1 in rat dorsal root ganglion

Kenji Abe1), Akiko Makabe2), Terumasa Chiba2), Toshie Kanbe3), Kazuyoshi Kawakami4), Iku Utsunomiya5), Toshihiro Hama4), Kyoji Taguchi1)
1)Dept. Pharmacol., Ohu Univ., 2)Dept. Medicinal Pharmacol., Showa Pharma. Univ., 3)Dept. Pharmacol., Showa Pharma. Univ., 4)Dept. Pharmacy, Cancer Insitute Hospital, 5)Dept. Pharmacotheraputics, Showa Pharma. Univ.
Journal of Pharmacological Sciences 121 (suppl) 188-188, 2013.

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P2-62 Macrophage-mediated angiogenesis and neuropathic pain after peripheral nerve injury

Norikazu Kiguchi, Shiroh Kishioka, Yuka Kobayashi, Yui Kadowaki, Naoki Wakida
Dept. Pharmacol., Wakayama Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 188-188, 2013.

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P2-63 Increased high mobility group box 1 in spinal dorsal horn plays a critical role in the maintenance of neuropathic pain in rats with partial sciatic nerve ligation

Yoki Nakamura1), Norimitsu Morioka1), Fangfang Zhang1), Hiromi Abe1),2), Kazue Hisaoka-Nakashima1), Keyue Liu3), Masahiro Nishibori3), Yoshihiro Nakata1)
1)Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2)Inst. Clin. Res., Natl. Hosp. Org. Kure Med. Ctr., 3)Dept. Pharmacol., Okayama Univ. Grad. Sch. Med., Dent. & Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 188-188, 2013.

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P2-64 Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone ameliorates postoperative pain by regulating macrophage polarization

Kohei Godai, Maiko Hasegawa-Moriyama, Tetsuya Ohnou, Yuichi Kanmura
Dept. Anethesiol., Kagoshima Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 188-188, 2013.

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P2-65 Analgesic effects of Shinryuu on inflammatory pain and neuropathic pain

Takahashi Ikuo1), Kousuke Morizumi1), Seiichi Katayama1), Hiroshi Atai1), Katsuhide Nishi1), Chie Konno2), Takeshi Hirano2), Yoshitake Tatebayashi2)
1)Mitsubishi Chemical Medience Corporation, 2)Tatebayashi Shokakudo Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 189-189, 2013.

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P2-66 Distinct physiological role of MOR-1J and MOR-1L on the mouse brain

Hirokazu Mizoguchi1), Chizuko Watanabe1), Akihiko Yonezawa1), Tsukasa Sakurada2), Shinobu Sakurada1)
1)Dept. Physiol. Anat., Tohoku Pharmaceut. Univ., 2)First Dept. Pharmacol.
Journal of Pharmacological Sciences 121 (suppl) 189-189, 2013.

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P2-67 Participation of peroxisome proliferator-activated receptor gamma(PPARγ) in morphine-tolerance and -dependence in mice

Shogo Nakajima1), Masanobu Ozaki2), Takehiko Maeda3), Shiroh Kishioka4)
1)Dept. Pharmacy, Minamihama Hosp., 2)Dept. Pharmacol. and Toxicol., Niigata Univ. Pharm. and Appl. Life Sci., Fac. Pharm. Sci., 3)Dept. Pharmacol., Niigata Univ. Pharm. and Appl. Life Sci., Fac. Pharm. Sci., 4)Dept. Pharmacol. Wakayama Medical Univ.
Journal of Pharmacological Sciences 121 (suppl) 189-189, 2013.

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P2-68 The current status of "uncontrolled drug" and effect of novel recreational drug such as α-PVP and ethylphenidate

Asuka Kaizaki, Sachiko Tanaka, Takashi Ashino, Satoshi Numazawa
Dept. Biochem. Toxicol., Showa Univ. Sch. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 189-189, 2013.

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P2-69 Studies of drug dependence (Rept. 491) Genetic background reflecting the conversion from discriminative stimulus to rewarding effects of psychostimulants in rats

Daisuke Aikawa, Tomohisa Mori, Tomoya Saeki, Masahiro Shibasaki, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 190-190, 2013.

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P2-70 Effect of nalfurafine hydrochloride on the basal pressure of the sphincter of Oddi in anesthetized rabbits

Kaoru Nakao, Ryosuke Kobayashi, Kiyoshi Yamada, Yohei Miyamoto, Hidenori Mochizuki
Pharmaceu. Res. Labs, Toray Industires, Inc.
Journal of Pharmacological Sciences 121 (suppl) 190-190, 2013.

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P2-71 KCNQ2 mutation facilitates spontaneous activity of hippocampal GABAergic neuron in neonate mice

Taku Uchida1),4), Masanobu Deshimaru2), Yuchio Yanagawa3), Susumu Koyama4), Shinichi Hirose1),5)
1)Central Res. Inst. Pathomecha. Epil., Fukuoka Univ., 2)Dept. of Chemistry, Sci., Fukuoka University, 3)Dept. of developmental and Integrative Neurosci., Gunma Univ. Grad. Sch. of Med., 4)Dept. of Psychosomatic Med., Pharm. Sci., Fukuoka Univ., 5)Dept. of Ped., Fukuoka Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 190-190, 2013.

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P2-72 Effects of KCNQ channel openers on drug-induced seizures in knock-in mice harboring KCNQ2 mutations

Ryo Saito1), Sayumi Okamatsu1), Yuko Tomonoh1),2),5), Satoko Kiyama1), Kenji Honda1), Kimi Araki4), Masanobu Deshimaru3), Shinichi Hirose2), Yukio Takano1)
1)Dept. Physiol. Pharmacol., Fac. Pharmaceut. Sci., Fukuoka Univ., 2)Dept. Pediat., Fac. Med., Fukuoka Univ., 3)Dept. Chem., Fac. Sci., Fukuoka Univ., 4)Inst. Mol. Embryol. Genetics, Kumamoto Univ., 5)Dept. Pediat., Takagi hospital
Journal of Pharmacological Sciences 121 (suppl) 190-190, 2013.

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P2-73 A cautious note on the interpretation of isobologram

Nobuko Matsumura, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 191-191, 2013.

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P2-74 Imaging of Ca2+ dynamics within the endoplasmic reticulum using new fluorescent Ca2+ indicators

Junji Suzuki1), Kazunori Kanemaru1), Kuniaki Ishii2), Masamichi Ohkura3), Masamitsu Iino1)
1)Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo, 2)Dept. Cardiovasc. Pharmacol., Grad. Sch. Med., Yamagata Univ., 3)Brain Sci. Inst., Saitama Univ.
Journal of Pharmacological Sciences 121 (suppl) 191-191, 2013.

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P2-75 Discovery of novel adenylyl cyclase inhibitor by cell-based screening

Hiroki Mano1), Tetsuya Ishimoto2), Hisashi Mori1),2)
1)Dept. Mol. Neurosci., Toyama Univ. Grad. Sch. Innov. Life Sci., 2)Dept. Mol. Neurosci., Toyama Univ. Grad. Sch. Med. Pharmaceu.
Journal of Pharmacological Sciences 121 (suppl) 191-191, 2013.

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P2-76 Silencing of calcium sensor protein stromal interaction molecule 1 (STIM1) suppresses cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells

Junko Yoshida1), Kuniyoshi Iwabuchi2), Takaharu Ishibashi1),3), Takayoshi Masuoka1), Matomo Nishio1)
1)Dept. Pharmacol., Kanazawa Med. Univ., 2)Dept. Biochem. I, Kanazawa Med. Univ., 3)Pharmacol. Sch. Nurs., Kanazawa Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 191-191, 2013.

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P2-77 TGFβ-induced proliferation of breast cancer stem cells via Notch signaling

Naoya Hirata, Shigeru Yamada, Yuko Sekino, Yasunari Kanda
Div. Pharmacol., Natl. Inst. Hlth. Sci.
Journal of Pharmacological Sciences 121 (suppl) 192-192, 2013.

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P2-78 AWT-489, a new indole compound, has antagonistic effects on DP prostanoid receptor

Satomi Oyama1), Hiromichi Fujino1), Atsuko Awata2), Takayoshi Arai2), Toshihiko Murayama1)
1)Lab. Chemical Pharmacol., Grad. Sch. Pharm. Sci., Chiba Univ., 2)Dept. Chemistry Grad. Sch. Science, Chiba Univ.
Journal of Pharmacological Sciences 121 (suppl) 192-192, 2013.

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P2-79 Development of abdominal aortic aneurysm (AAA) in rats

Emi Morita, Ryoji Mizumachi, Yuuji Murata, Namie Beppu, Kazufumi Kawasako, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Pharmacology Department Nonclinical Research Center Drug Development Service Segment
Journal of Pharmacological Sciences 121 (suppl) 192-192, 2013.

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P2-80 Study of atherosclerosis-related gene expression of lifestyle-related diseases model rats using DNA microarray analysis

Go Koizumi1),2), Go Oda2), Keiichirou Ohba1),2), Toshio Kumai2), Shinichi Iwai1),3), Minoru Watanabe4),5), Naoki Matsumoto4), Katsuji Oguchi1)
1)Dept. Pharmacol. Showa Univ. Sch. Med., 2)Dept. Pharmacogenom. St. Marianna Univ. Grad. Sch. Med., 3)Dept. Health. and Reg. Sci., Sch. Pharma., 4)Dept. Pharmacol. St. Marianna Univ. Sch. Med., 5)Inst. Animai Exp., St. Marianna Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 192-192, 2013.

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P2-81 The pathologic conditions of the spontaneously infertile rat and the elucidation of its infertile mechanisms

Minoru Watanabe1),2), Naoki Matsumoto2), Yuko Takeba2), Sachiko Takenoshita2), Yuki Ohta2), Toshio Kumai3), Masami Tanaka4)
1)Inst. Animal Exp. St. Marianna Univ. Grad. Sch. of Med., 2)Dept. Pharmacol., St. Marianna Univ. Sch. Med., 3)Dept. Pharmacogenomics, St. Marianna Univ. Grad Sch. Med., 4)Dept. of Nutrition, Junior College Div., The Univ. of Aizu
Journal of Pharmacological Sciences 121 (suppl) 193-193, 2013.

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P2-82 Histopathological and biochemical changes at different age of SHR/NDmcr-cp

Toshinori Moritani, Takashi Shimosato, Daisuke Saji, Noriko Minobe, Mikito Kikumori, Miki Shirahata, Hitomi Matsuda, Ayahito Kimura, Hiroshi Sakonjo
NISSEI BILIS Co., Ltd., Shiga Laboratory
Journal of Pharmacological Sciences 121 (suppl) 193-193, 2013.

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P2-83 Development of a new diabetes model in Microminipig

Jun-ichi Fuchikami, Masaru Sugiyama, Hiroyuki Saito, Maki Takahashi, Yoshiyuki Suzuki, Akemi Saito
CMIC BIORESEARCH CENTER Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 193-193, 2013.

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P2-84 Identification of highly glycosylated lipocalin 2 from urine of model mouse for drug-induced acute kidney injury

Yoko Fujiwara, Hiroyoshi Tsuchiya, Akio Fujimura, Taka-aki Koshimizu
Div. of Mol. Pharmacol., Dep. of Pharmacol., Jichi Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 193-193, 2013.

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P2-85 Etodolac activates and desensitizes transient receptor potential ankyrin 1 through cysteine modification

Shenglan Wang1),2), Koichi Noguchi2), Yi Dai1),2)
1)Dept. Pharm., Hyogo Univ. Hlth. Sci., Sch. Pharm., 2)Dept. Anat. Neurosci., Hyogo Coll. Med.
Journal of Pharmacological Sciences 121 (suppl) 194-194, 2013.

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P2-86 Nicotine facilitates the reinnervation of injured perivascular nerves

Kenta Hagimori1), Hidetoshi Fujiwara2), Tangsucharit Panot1), Hiromu Kawasaki2), Fusako Takayama1)
1)Dept. Front. Health, Grad. Sch. Med. Den. Pharmac. Sci., Okayama Univ., 2)Dept. Clin. Pharmac. Sci., Grad. Sch. Med. Den. Pharmac. Sci., Okayama Univ.
Journal of Pharmacological Sciences 121 (suppl) 194-194, 2013.

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P2-87 The Effectiveness of Gabapentin for the Prevention of Postherpetic Neuralgia in Patients with Acute Herpes Zoster

Qiushi Wang, Wenyao Cui, Tao Song
Dept Anes., 1st Hosp. China Med Univ.
Journal of Pharmacological Sciences 121 (suppl) 194-194, 2013.

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P2-88 Effect of pilocarpine on Ca2+ response and secretion in rat salivary gland

Akihiro Nezu1), Takao Morira1), Yosuke Tojyo1),2), Akihiko Tanimura1)
1)Dept. of Pharmacol., Sch. of Dent., Health Sci. Univ. of Hokkaido, 2)Lab. of Biophys., Sch. of Dent., Health Sci. Univ. of Hokkaido
Journal of Pharmacological Sciences 121 (suppl) 194-194, 2013.

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P2-89 Up-regulation of the positive regulators of Kca3.1 K+ channel in auricular CD4+ cells of DTH mice model

Susumu Ohya1),2), Miki Matsui2), Hiroaki Kito2), Sayuri Horiba2), Erina Nakamura2), Masanori Fujii1), Hisao Yamamura2), Yuji Imaizumi2)
1)Dept. Pharmacol., Kyoto Pharmaceut. Univ., 2)Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 195-195, 2013.

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P2-90 Soluble CD26/Dipeptydil peptidase IV enhances the Toll Like Receptor (TLR) response on THP-1 cells and human monocytes

Tetsuro Ikeda1), Emi Kumagai1), Atsushi Iwata1), Akio Yamakawa2), Yoshinori Murakami3), Chikao Morimoto1)
1)Dept. Clinical Immunology., Tokyo Univ. Institute of Med., 2)Dept. GCOE promotion., Tokyo Univ. Institute of Med., 3)Dept. Molecular Path., Tokyo Univ. Institute of Med.
Journal of Pharmacological Sciences 121 (suppl) 195-195, 2013.

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P2-91 Stromal fibroblastic cells negatively self-regulate tissue remodeling through cyclooxygenase-2 in draining lymph nodes of acute inflammation

Michiko Kawamura1), Yoshihito Tada2), Yoshiteru Harada2)
1)Dept. Pharmacol., Kitasato Univ. Sch. Med., 2)Dept. Mediator & Signal Transduction Pharmacol., Kitasato Univ. Graduate Sch. Medical Sciences
Journal of Pharmacological Sciences 121 (suppl) 195-195, 2013.

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P2-92 Role of COX-2 in enhancement of lymphangiogenesis in diaphragm after the peritoneal application of endotoxin

Hiromi Matsuda, Kanako Hosono, Chie Kurashige, Masataka Maxima
Dept. of Pharmacol., Kitasato Uni. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 195-195, 2013.

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P2-93 Secretion and re-entry of exosomes in the activated murine macrophages RAW264.7

Hiroaki Naraba, Kanako Sasaki, Chihiro Yagishita, Kanae Onodera, Daisuke Yasunaga, Tomoko Sakyo, Takayuki Kitagawa
Dept. Cell Biol. and Mol. Pathol. Sch. Pharm., Iwate Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 196-196, 2013.

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P2-94 Effects of oxatomide on ATP-mediated responses at P2X7 receptor in N18TG2 cells

Kazuki Yoshida, Masa-aki Ito, Isao Matsuoka
Lab. Pharmacol. Facul. Pharm. Takasaki Univ. Health and Welfare
Journal of Pharmacological Sciences 121 (suppl) 196-196, 2013.

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P2-95 The effects of purinergic agonists on allergic degranulation in human-derived mast cell line, LAD2

Haruhisa Nishi
Dept. Pharmacol. Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 196-196, 2013.

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P2-96 Inhibitory effects of GlcNAc polymers on the histamine release from mast cells by Datura stramonium agglutinin

Tamiko Suzuki-Nishimura, Tomonari Hosokawa, Yuuki Kato
Pharmacy School, Shujitsu Univ.
Journal of Pharmacological Sciences 121 (suppl) 196-196, 2013.

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P2-97 The role of signal transduction molecules and TACE on the regulation of c-kit expression on mast cells

Risa Hasegawa, Nobuyuki Fukuishi, Hayato Teruya, Seita Nozaki, Yousuke Hata, Yuuki Hinomoto, Yasuyuki Shintani, Nobuaki Matsui, Masaaki Akagi
Dept. Pharmacol., Fac. Pharm. Sch., Tokushima Bunri Univ.
Journal of Pharmacological Sciences 121 (suppl) 197-197, 2013.

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P2-98 TRPA1 channel is a key regulator of intracellular Zn2+ in inflammatory synoviocytes

Katsuhiko Muraki1), Noriyuki Hatano1), Hiroka Suzuki1), Yuka Itoh2), Yukiko Muraki1), Hidetoshi Hayashi2), Kikuo Onozaki3)
1)Lab. Cellular Pharmacol. Sch. Pharm., Aichi-gakuin Univ., 2)Dept. Drug Metab. Dispos., Grad. Sch. Pharmaceut. Sci. Nagoya City Univ., 3)Dept. Mol. Health Sci., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 197-197, 2013.

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P2-99 Role of adenosine A2a receptors in the growth control of a gefitinib-resistant non-small cell lung cancer cell growth

Maki Noguchi1), Naoko Kuzumaki1),2), Atsumi Nagasawa1), Michiko Narita1), Minoru Narita1)
1)Dept. Pharamcol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2)Dept. Physiol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 197-197, 2013.

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P2-100 Functional characterization of novel tumor suppressor protein Sav1 in human cancer cells

Nobuya Sakai, Katsushi Shibata
Fac. Pharm. Sci., Himeji Dokkyo Univ.
Journal of Pharmacological Sciences 121 (suppl) 197-197, 2013.

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P2-101 Comparison of the expression levels of tumor suppressor protein, Pdcd4 in two mouse melanoma cell lines with different metastatic ability

Jing-zi Xu1), Noriko Yoshikawa1), Sayaka Sasaki1), Yuta Takahashi1), Satomi Kagota2), Kazumasa Shinozuka2), Kazuki Nakamura1)
1)Dept. Pharmacol. I, Mukogawa Woman's Univ. Sch. Pharm., 2)Dept. Pharmacol. II, Mukogawa Woman's Univ. Sch. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 198-198, 2013.

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P2-102 Functional analysis of choline transporter in pancreatic cancer cells

Masato Inazu, Jun Sasaki, Mitsuru Moriyama, Ryusaku Hosoya, Rei Tai
Institute of Medical Science, Tokyo Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 198-198, 2013.

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P2-103 Repeated prenatal psychological stress induces emotional deficits in the adolescence

Genki Ohashi, Yuki Tsuruoka, Yoshitaka Miyamura, Takenao Koseki, Akihiro Mouri, Masayuki Hiramatsu, Takayoshi Mamiya, Toshitaka Nabeshima
Dept. Chem. Pharmacol., Fac. Pharmaceu. Sci., Meijo Univ.
Journal of Pharmacological Sciences 121 (suppl) 198-198, 2013.

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P2-104 The influence of chronic stress stimuli on the cognitive function after the ethanol withdrawal in mice

Hideaki Kato, Minoru Tsuji, Kazuya Miyagawa, Hiroshi Takeda
Dept. Pharmacol., Sch. Pharm., Int Univ. Health and Welfare
Journal of Pharmacological Sciences 121 (suppl) 198-198, 2013.

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P2-105 Chronopharmacological analysis of antidepressant activity of serotonin-noradrenaline reuptake inhibitor, milnacipran

Hiroshi Kawai, Megumi Machida, Ayano Igari, Takuya Ishibashi, Atsushi Mitsumoto
Facul. Pharmaceut. Sci., Josai Int. Univ.
Journal of Pharmacological Sciences 121 (suppl) 199-199, 2013.

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P2-106 Circadian clock-controlled the expression of dopamine D3 receptor (drd3) in mouse striatum

Eriko Ikeda, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Dept. Pharmaceuti., Grad. Sch., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 199-199, 2013.

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P2-107 Regulatory mechanism of circadian rhythm of mTOR signaling in mouse tumor tissue

Hiroyuki Okazaki, Naoya Matsunaga, Takashi Fujioka, Satoru Koyanagi, Shigehiro Ohdo
Dept. Pharmaceuti., Grad. Sch., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 199-199, 2013.

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P2-108 cAMP-response element(CRE)-mediated transcription by ATF4 sustains the molecular circadian clock

Satoru Koyanagi1), Ahmed Hamdan2), Michiko Horiguchi3), Naoki Kusunose1), Naoya Matsunaga1), Ohdo Shigehiro1)
1)Dept. Pharmaceutics, Grad. Sch. Pharmaceuti. Sci., Kyushu Univ., 2)Max-Planck-Institut., Am Fassberg II, Georg-August-Universitat Gottingen, 3)Faculti. Pharmaceuti. Tokyo Univ. Sci.
Journal of Pharmacological Sciences 121 (suppl) 199-199, 2013.

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P2-109 Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors

Shoya Siromizu1), Michiko Horiguchi2), Akinori Okamoto1), Naoya Matsunaga1), Satoru Koyanagi1), Shigehiro Ohdo1)
1)Dept. Pharmaceutics. Grad. Sch. Pharmaceuti. Sci., Kyushu Univ., 2)Faculti. Pharmaceuti. Tokyo Univ. Sci.
Journal of Pharmacological Sciences 121 (suppl) 200-200, 2013.

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P2-110 Rhythmic regulation of ARF-MDM2 pathway by ATF4 underlies circadian accumulation of p53 protein in malignant tumor cells

Michiko Horiguchi1), Satoru Koyanagi2), Shoya Shiromizu2), Hirokazu Sasaki2), Ahmed Hamdan3), Naoya Matsunaga2), Shigehiro Ohdo2)
1)Faculti. Pharmaceuti. Tokyo Univ. Sci., 2)Dept. Pharmaceutics. Grad. Sch. Pharmaceuti. Sci., Kyushu Univ., 3)Max-Planck-Institut., Am Fassberg II, Georg-August-Universitat Gottingen
Journal of Pharmacological Sciences 121 (suppl) 200-200, 2013.

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P2-111 AMPK activation is induced the disruption of molecular clock in the MPTP mouse model of Parkinson

Naoya Matsunaga, Akane Hayashi, Yoshinori Kimura, Hiroyuki Okazaki, Hiroki Azuma, Keisuke Kakimoto, Eriko Ikeda, Satoru Koyanagi, Shigehiro Ohdo
Dept. Pharmaceutical., Univ. Kyushu.
Journal of Pharmacological Sciences 121 (suppl) 200-200, 2013.

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P2-112 24-hr rhythm of Iron and Iron Regulatory Protein 2 are regulated by circadian clock genes in colon cancer-bearing mice

Hiroki Azuma, Naoya Matsunaga, Hiroyuki Okazaki, Fumiyasu Okazaki, Satoru Koyanagi, Shigehiro Ohdo
Dept. Pharmacol., Kyushu Univ. Pharmaceuti. Sci., Kyushu University
Journal of Pharmacological Sciences 121 (suppl) 200-200, 2013.

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P2-113 Molecular basis for rhythmic expression of cytochromes P450 (CYPs) in serum-shocked HepG2 cells

Keisuke Kakimoto, Naoya Matsunaga, Takako Takiguchi, Miki Inoue, Naoki Kusunose, Kengo Hamamura, Satoru Koyanagi, Shigehiro Ohdo
Dept. Pharmaceuti., Grad. Sch., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 201-201, 2013.

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P2-114 Involvement of secretory phospholipase A2 in the rhythmic contraction of pulmonary arteries produced by stretching in monocrotaline-induced pulmonary arterial hypertensive rats and possible implication for the pathogenicity

Maki Saito-Tanji1), Yoshiyuki Tanabe1), Akihisa Kamataki2), Takashi Sawai2), Koichi Nakayama1)
1)Dept. Mol. Cell. Pharmacol., Iwate Med. Univ. Sch. Pharm., 2)Dept. Pathol., Iwate Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 201-201, 2013.

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P2-115 A molecular mechanism regulating the dosing time-dependent change in the cisplatin-induced nephrotoxicity in mice

Masayuki Oda, Yuuya Tsurudome, Naoya Matsunaga, Satoru Koyanagi, Sigehiro Ohdo
Dept. Pharmaceutics. Grad. Sch. Pharmaceuti. Sci. Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 201-201, 2013.

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P2-116 The influence of soyaflavone HG on the period of mouse clock gene expression in vitro and in vivo

Mari Kuwahara, Keisuke Saito, Seira Narishige, Shigenobu Shibata
Lab. Physiology and Pharmacology., Waseda Univ. Sch. ASE
Journal of Pharmacological Sciences 121 (suppl) 201-201, 2013.

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P2-117 Improvement of walking performance by combination of cilostazol and L-carnitine in rats with hindlimb ischemia

Toshinori Shiga, Yoriko Sekine, Kensuke Orito
Dept. Physiol II., Azabu Univ. Sch. Vet Med.
Journal of Pharmacological Sciences 121 (suppl) 202-202, 2013.

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P2-118 A Circadian regulation of glutathione and its neuroprotective role in dopaminergic neuron

Chisato Kinoshita, Nobuko Matsumura, Kazue Kikuchi-Utsumi, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 202-202, 2013.

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P2-119 BMP4 is increased in the aortas of diabetic ApoE knockout mice and enhances oxidized low density lipoprotein uptake in peritoneal macrophages

Yuki Kanaoka, Mitsuhisa Koga, Ryusuke Jige, Anna Tsukamoto, Nao Teshima, Tsuyoshi Nishioku, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharmacy, Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 202-202, 2013.

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P2-120 Telmisartan attenuated vascular injury via PPAR-γ-modulating activity in hypertensive CKD rat

Yoshimitsu Matsuda, Hiroe Toba, Yurina Otsuka, Yuna Kamada, Narumi Chikamatsu, Jiahong Wang, Kazuki Noda, Wei Tian, Miyuki Kobara, Tetsuo Nakata
Dept. Clinical Pharmacology, Kyoto Pharmaceutical University
Journal of Pharmacological Sciences 121 (suppl) 202-202, 2013.

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P2-121 Celiprolol attenuates hypoxia-induced left ventricular remodeling in mice

Satoshi Nishioka1), Atsuo Nomura2), Ryuji Kato2), Masatoshi Miyamura3), Mamoru Ohkita1), Yoshikatsu Okada4), Nobukazu Ishizaka3), Tetsuya Hayashi2), Yasuo Matsumura1)
1)Lab. Pathol. and Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci., 2)Lab. Cardiovase. Pharmacother. and Toxicol., Osaka Univ. Pharmaceut. Sci., 3)Dept. Int Med III., Osaka Med. Coll., 4)Dept. pathol., Osaka Med. Coll.
Journal of Pharmacological Sciences 121 (suppl) 203-203, 2013.

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P2-122 Brain-derived neurotrophic factor (BDNF) generates oxidative stress in vascular endothelial and smooth muscle cells

Tatsuya Usui, Akihiro Naruo, Muneyoshi Okada, Yukio Hara, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 203-203, 2013.

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P2-123 The aim at the reduction of the adverse effect of the anti-hormonal therapies for prostate cancer and breast cancer

Yutaka Matsuoka, Yui Kawasaki
Lab. Medicinal Sci., Fac. Pharm. Sci., Tokyo Univ. Sci.
Journal of Pharmacological Sciences 121 (suppl) 203-203, 2013.

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P2-124 Fundamental properties of mitochondrial Na+/Ca2+ exchanger (NCLX)

Makoto Fujii, Satomi Kita, Takahiro Iwamoto
Dept. Pharmacol., Fac. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 203-203, 2013.

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P2-125 TRIC-A regulate SR Ca2+ distribution in vascular smooth muscle cells

Daiju Yamazaki, ShengChen Tao, Hiroshi Takeshima
Dept. Biol. Chem., Grad. Sch. of Pharmaceut. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 204-204, 2013.

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P2-126 Actin-binding domain of myosin light chain kinase in the proliferation of vascular smooth muscle cells

Hiromi Takano-Ohmuro3), Honghui Wang1), Akio Nakamura2), Shinji Yoshiyama2), Ryoki Ishikawa2), Cai Na1), Lihong Ye1), Kazuhiro Kohama3)
1)Dept. Biochemistry, College of Life Science, Nankai Univ., 2)Dept. Pharmacol. Gunma Univ. Graduate School, 3)Fac. Pharm. & Res. Inst. Pharmaceutical Sci. Musashino Univ.
Journal of Pharmacological Sciences 121 (suppl) 204-204, 2013.

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P2-127 Differential functional coupling of Na+/Ca2+ exchanger and Na+, K+-ATPase in rodent arterial tissues

Ichiro Horie, Satomi Kita, Takahiro Iwamoto
Dept. Pharmacol., Facul. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 204-204, 2013.

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P2-128 Exendin-4, a glucagon-like peptide-1 analogue, inhibits 5-hydroxytryptamine-induced vasocontraction in the isolated human endothelium-denuded saphenous vein

Tasuku Kanai1), Shuji Gamoh1), Naoko Totoribe1), Masachika Kuwabara2), Eisaku Nakamura3), Hiroaki Hisa4), Ryuichi Yamamoto1)
1)First Dept. Pharmacol., Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare, 2)Kuwabara Clinic, 3)Dept. Cardiovasc. Surg. Miyazaki Pref., 4)Second Dept. Pharmacol., Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare, 5)Pharmaceut. Biol., Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare
Journal of Pharmacological Sciences 121 (suppl) 204-204, 2013.

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P2-129 Genetic analysis of vascular smooth muscle cells exposing nicotine

Shinji Yoshiyama, Zhenyi Chen, Kazuhiro Kohama, Akio Nakamura
Dept. Mol. & Oncol. Pharmacol., Gunma Univ., Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 205-205, 2013.

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P2-130 Y-27632, a rho-kinase inhibitor, inhibits inorganic phosphate-induced ERK1/2 phosphorylation and ALP activity in vascular smooth muscle cells

Yuki Izawa-Ishizawa1), Keisuke Ishizawa2), Sakiko Doi1), Masaki Imanishi1), Takumi Sakurada1), Noriko Yamano1), Yusuke Kohara2), Tomoko Nagao2), Yoshitaka Kihira1), Yasumasa Ikeda1), Koichiro Tsuchiya2), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 2)Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 205-205, 2013.

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P2-131 Effect of EPA on skeletal and cardiac muscle of infants of diabetic mother rats

Ritsuko Kawaharada1), Akio Nakamura2)
1)Dept. of Health and Nutri., Takasaki Univ. of Health and Welf., 2)Dept. Mol. Pharmacol. & Oncol., Gunma Univ. Sch. of Med.
Journal of Pharmacological Sciences 121 (suppl) 205-205, 2013.

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P2-132 Nitric oxide mediates purinergic P2Y2 receptor-induced cardiac cell senescence via formation of nitrated byproduct

Motohiro Nishida1), Yoji Sato2), Kazuhide Inoue3), Hitoshi Kurose4)
1)Dept. Drug. Discov. Evol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2)Div. Cell Gene Therap. Prod., 3)Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 4)Dept. Pharmacol. Toxicol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 205-205, 2013.

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P2-133 TRPC3 contributes to NADPH oxidase-mediated production of reactive oxygen species

Naoyuki Kitajima1), Takuro Numaga2), Yoji Sato3), Yasuo Mori2)
1)Dept. Drug Discov. and Evol., Grad. Sch. of Pharm. Sci., Kyushu Univ., 2)Dept. Synthet. Chem. and Biol. Chem., Kyoto Univ., Grad. Sch. of Engn., 3)Div. of Cell. & Gene Therap. Prod., Nat. Inst. of Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 206-206, 2013.

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P2-134 Evidence, hypotheses and significance of MAP kinase TNNI3K interacting with its partners

Zhong-Fang Lai1), Yu-Zhen Chen1), Tsuda Hiroshisa1), Yasunori Kitamoto2), Shokei Kim-Mitsuyama1)
1)Dept. Pharmacol. Mol. Therap., Grad. Sch., Kumamoto Univ., 2)Sendai Shakaihoken Hosp.
Journal of Pharmacological Sciences 121 (suppl) 206-206, 2013.

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P2-135 Localization of a non-genomic pathway of cardiac progesterone receptors

Sayuri Goryoda, Masami Kodama, Tetsushi Furukawa, Junko Kurokawa
Dept. Bio-Informational Pharmacol., MRI, Tokyo Med Dent Univ.
Journal of Pharmacological Sciences 121 (suppl) 206-206, 2013.

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P2-136 α-Adrenoceptor mediated inotropy in neonatal and adult mouse ventricular myocardium is influenced by action potential duration

Shogo Hamaguchi, Yuko Shiseki, Yoriko Honda, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 206-206, 2013.

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P2-137 Effect of tyramine on the production of interstitial adenosine during perfusion with AMP in rat hearts in vivo

Toshio Obata
Yokkaichi Nursing and Medical Care University
Journal of Pharmacological Sciences 121 (suppl) 207-207, 2013.

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P2-138 Effect of the short-term anchusan treatment on CYP3A4-mediated metabolism in healthy subjects

Takehiko Sambe, Yuki Nishimura, Naoki Uchida, Mariko Iwase, Hirokazu Toshima, Kakei Ryu, Momoko Kawakami, Yoshie Harimoto, Katsuji Oguchi, Shinichi Kobayashi
Dept. Pharmacol., Showa Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 207-207, 2013.

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P2-139 Comparative effect of angiotensin II type I receptor blockers and calcium channel blockers on laboratory parameters in hypertensive patients with type 2 diabetes

Yayoi Nishida1), Yasuo Takahashi1),2), Satoshi Asai2),3)
1)Div. Genomic Epidemiol. Clin. Trails, Nihon Univ. Sch. Med., 2)Medical Research Center, Nihon Univ. Sch. Med., 3)Dept. Pharm, Nihon Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 207-207, 2013.

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P2-140 Probing trans- and cis-inhibitory effect of benzbromarone and its metabolite on URAT1-mediated urate uptake

Promsuk Jutabha1), Hitoshi Endou2), Naohiko Anzai1)
1)Dept. Pharmacol. Toxicol., Dokkyo Medical Univ. Sch. Med., 2)J-Pharma Co. Ltd.
Journal of Pharmacological Sciences 121 (suppl) 207-207, 2013.

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P2-141 Cyclic stretch on glomerular endothelial cells, a new in vitro model for glomerular hypertension

Yasuyuki Irie, Yukiko Kondo, Naoko Matushita, Eiichi Taira
Dept. Pharmacol., Iwate Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 208-208, 2013.

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P2-142 Dysfunction of vascular modulating system in experimental chronic kidney diseases model mice

Mayumi Mori1), Miyuki Ito1),2), Yoshinari Yasuda2)
1)Dept. Pharmacol., Nagoya City Univ., Grad. Sch. Med. Sci., 2)Dept. CKD Initiat/Nephrol., Int. Med., Nagoya Univ., Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 208-208, 2013.

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P2-143 Pharmacological profile of FYU-981, a novel potent uricosuric agent

Tetsuya Taniguchi, Koji Matsumoto, Naoki Ashizawa, Takashi Iwanaga, Osamu Nagata, Kazuhiro Saitoh
Research Laboratories 2, Fuji Yakuhin Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 208-208, 2013.

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P2-144 Analysis of the role of NOX1/NADPH oxidase in renal electrolyte homeostasis

Maya Tanaka, Misaki Matsumoto, Kazumi Iwata, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 121 (suppl) 208-208, 2013.

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P2-145 Molecular mechanisms underlying vancomycin-induced renal cell apoptosis and the protective effects of antioxidants

Yuya Sakamoto1), Takahisa Yano2), Yuki Ushijima1), Yuki Hanada1), Megumi Hirano2), Nobuaki Egashira1),2), Ryozo Oishi1),2)
1)Fac. Sch. Pharm. Sci., Kyushu Univ., 2)Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 209-209, 2013.

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P2-146 Involvement of Osp94, a hypertoic stress sensitive molecular chaperone, in autophagy/lysosome pathway for the clearance of denatured proteins

Ryoji Kojima, Yukako Mizutani, Mikio Ito
Lab. Anal. Pharmacol., Fac. Pharm. Meijo Univ.
Journal of Pharmacological Sciences 121 (suppl) 209-209, 2013.

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P2-147 Effects of lipopolysaccharide on respiratory tract of mice

Motomu Tanaka1), Noriko Murai2), Kayoko Tanaka2), Kei Maruyama1)
1)Dept. Pharmacol., Saitama Med. Univ., 2)Div. Morph. Sci. Biomed. Res. Cent., Saitama Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 209-209, 2013.

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P2-148 Down-regulation of miR-140-3p contributes to up-regulation of CD38 protein in bronchial smooth muscle cells

Yoshihiko Chiba1), Mayumi Matsumoto2), Yasuna Kato2), Keiko Ando2), Kazuki Shimizu1), Rena Suto1), Wataru Suto1), Gen Tanoue1), Shunta Danno1), Takahumi Nakabaru1), Hiroyasu Sakai2), Minoru Narita2)
1)Dept. Biol., Hoshi Univ. Sch. Pharm., 2)Dept. Pharmacol., Hoshi Univ. Sch. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 209-209, 2013.

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P2-149 Combination effects of PI3Kγ and δinhibitors on the corticosteroid-refractory airway hyperresponsiveness induced by polyinosinic-polycytidylic acid in mice

Genki Kimura1), Keitaro Ueda1), Takashi Masuko1), Kazuhiro Ito2), Tadashi Kusama1), Yasuo Kizawa1)
1)Dept. Physiol. & Anat., Nihon Univ. Sch. Pharm., 2)NHLI, Imperial Coll.
Journal of Pharmacological Sciences 121 (suppl) 210-210, 2013.

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P2-150 Effects of combination of PI3Kδ and γ inhibitors to each inhibitor alone on airway inflammation induced by lipopolysaccharide in mice

Keitaro Ueda1), Genki Kimura1), Takashi Masuko1), Kazuhiro Ito2), Tadashi Kusama1), Yasuo Kizawa1)
1)Dept. Physiol. & Anat., Nihon Univ. Sch. Pharm., 2)NHLI, Imperial Coll.
Journal of Pharmacological Sciences 121 (suppl) 210-210, 2013.

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P2-151 STUDY OF MEASUREMENT ON RESPIRATORY FUNCTION BY WHOLEBODY PLETHYSMOGRAPHY (WBP) IN UNANESTHETIZED AND UNRESTRAINED MICROMINIPIGS

Kazuaki Sasaki, Chengjun Ma, Masakazu Imaizumi, Hiroshi Atai, Katsuhide Nishi
MITSUBISHI CHEMICAL MEDIENCE CORPORATION
Journal of Pharmacological Sciences 121 (suppl) 210-210, 2013.

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P2-152 Activation of TRPV1 by capsaicin increases gastric motility in conscious mice using 13C-acetic acid breath test

Kimihito Tashima, Kazuki Hashimoto, Teturou Kamoshita, Akio Takagaki, Kenjiro Matsumoto, Syunji Horie
Lab. Pharmacol., Fac. Pharm. Sci., Josai International Univ.
Journal of Pharmacological Sciences 121 (suppl) 210-210, 2013.

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P2-153 A role for peptide YY in tachykinin NK2 receptor-triggered 5-HT release from guinea-pig colonic mucosa

Shu-ichi Kojima1), Atsushi Tohei2), Naohiko Anzai1)
1)Dept. Pharmacol. & Toxiol., Dokkyo Med. Univ. Sch. Med., 2)Lab. Exp. Animal Sci. Nippon Vet., & Life Sci. Univ.
Journal of Pharmacological Sciences 121 (suppl) 211-211, 2013.

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P2-154 Stimulation of the α7 nicotinic acetylcholine receptor is required for the anti-inflammatory effects of tropisetron on dextran sodium sulfate-induced colitis

Yuichi Tasaka1), Daiki Yasunaga1), Akihiro Tanaka1), Katsuya Suemaru2), Hiroaki Araki1)
1)Div. Pharmacy, Ehime Univ. Hosp., 2)School of Pharmacy, Shujitu Univ.
Journal of Pharmacological Sciences 121 (suppl) 211-211, 2013.

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P2-155 Nicotine suppresses colonic tumorigenesis associated with chronic colitis in mice

Shusaku Hayashi, Takayuki Hamada, Makoto Kadowaki
Div. Gastrointestinal Pathophysiol., Inst. Natural Med., Univ. Toyama
Journal of Pharmacological Sciences 121 (suppl) 211-211, 2013.

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P2-156 Roles of ileal substance P synthesis in pica behavior on rats administrated with anti-cancer drugs

Takuji Machida, Natsuki Kato, Shintaro Kato, Saki Sekiya, Mai Ito, Kenji Iizuka, Masahiko Hirafuji
Dept. Pharmacol., Facul. Pharm. Sci., Health Sci. Univ. of Hokkaido
Journal of Pharmacological Sciences 121 (suppl) 211-211, 2013.

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P3-1 Effect of a catechol-O-methyltransferase inhibitor on the brain concentrations of L-threo-3, 4-dihydroxyphenylserine (L-DOPS) and norepinephrine in rats administered L-DOPS

Masanori Yamamoto1), Yutaka Konya2), Toichiro Yamada2)
1)Pharmacol. Research Lab., Dainippon Sumitomo Pharma Co., Ltd., 2)Pharmacokinetics Research Lab., Dainippon Sumitomo Pharma Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 212-212, 2013.

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P3-2 Maternal nicotine exposure impairs the development of catecholaminergic system in the brahs of offspring

Yuki Aoyama1),2), Tursun Alkam2), Kazuya Toriumi2), Taku Nagai1), Toshitaka Nabeshima2),3),4), Kiyofumi Yamada1),4)
1)Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 2)Dept. Chem. Pharm. Meijo Univ. Grad. Sch. Pharm., 3)Dept. Region. Pharmaceuti. Care Sci., Meijo Univ. Grad. Sch. Pharm., 4)Japanese Drug Organi. Appropri. Use Research
Journal of Pharmacological Sciences 121 (suppl) 212-212, 2013.

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P3-3 Effects of three peptidase inhibitors on antinociceptive action of Dynorphin A(1-17) without toxicity by intracerebroventricular administration in rats

Junko Ajimi1), Masanobu Yoshikawa2), Masaaki Miura1), Shigeru Takahashi2), Hiroyuki Kobayashi2), Toshiyasu Suzuki1)
1)Dept. Anesthsiol., Tokai Univ. Sch. Med., 2)Dept. Clinical Pharmacol., Tokai Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 212-212, 2013.

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P3-4 Effects of one or three peptidase inhibitors on antinociception of [Leu5]-enkephalin by intrathecal administration in rats

Masaaki Miura1), Masanobu Yoshikawa2), Mariko Watanabe1), Shigeru Takahashi2), Junko Ajimi1), Hiroyuki Kobayashi2), Toshiyasu Suzuki1)
1)Dept. Anesthesiol., Tokai Univ. Sch. Med., 2)Dept. Clin. Pharmacol., Tokai Univ. Sch Med.
Journal of Pharmacological Sciences 121 (suppl) 212-212, 2013.

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P3-5 Contribution of α2A adrenoceptor to effect of α2 agonists on spinal reflex potential

Takeshi Kobayashi, Ken-ichi Otsuguro, Soichiro Yamaguchi, Shigeo Ito
Lab. Pharmacol., Grad. Sch. Vet. Med. Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 213-213, 2013.

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P3-6 Characterization of human noradrenaline transporter gene at 5'-flanking region

Chiharu Sogawa1), Kazumi Ohyama2), Norio Sogawa1), Shigeo Kitayama1)
1)Dept. Dent. Pharmacol., Okayama Univ. Grad. Sch. Med. Dent. Pharm. Sci., 2)Okayama Univ. Dent. Sch. RI center
Journal of Pharmacological Sciences 121 (suppl) 213-213, 2013.

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P3-7 Post-transcriptional regulation of noradrenaline transporter by nicotine

Kazumi Ohyama1), Chiharu Sogawa2), Xuefang Wen2), Katsuya Morita3), Norio Sogawa2), Shigeo Kitayama2)
1)RI Lab., Okayama Univ. Dent. Sch., 2)Dept. Dent. Pharmacol., Okayama Univ. Grad. Sch. Med. Dent. Pharmac. Sci., 3)Dept. Dent. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 121 (suppl) 213-213, 2013.

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P3-8 Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system

Yukie Kawahara1), Fumi Kaneko1), Makiko Yamada1), Yuki Kishikawa1), Hiroshi Kawahara2), Akinori Nishi1)
1)Dept. Pharmacol., Kurume Univ. Sch. Med., 2)Dept. Dent. Anesth., Tsurumi Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 213-213, 2013.

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P3-9 Concomitant activation of α1-receptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats

Yuri Aono1), Tadashi Saigusa1), Hiroko Taguchi2), Alexander.R Cools3)
1)Dept. Pharmacol., Nihon univ. Sch. Dent., 2)Dept. Orthodont., Nihon univ. Sch. Dent., 3)Psychoneuropharmacol., Dept. Cognitive Neurosci. Radboud univ. Nijmegen
Journal of Pharmacological Sciences 121 (suppl) 214-214, 2013.

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P3-10 In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anaesthetized mice

Dong-Yun Zhan, Cheng-Kun Du, Tsuyoshi Akiyama, Takashi Sonobe, Mikiyasu Shirai
Dept. of Cardiac Physiol., Natl. Cereb. Cardiovas. Res. Ctr. Inst.
Journal of Pharmacological Sciences 121 (suppl) 214-214, 2013.

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P3-11 Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor

Noriaki Satoh1), Yumiko Toyohira2), Keita Takahashi2), Susumu Ueno3), Masato Tsutsui4), Nobuyuki Yanagihara2)
1)Bio-information Research Center, Univ. Occup, Environ. Health, 2)Dept. Pharmacol., Sch. Med., Univ. Occup. Environ. Health, 3)Dept. Occup. Toxicol., Inst. Indust. Ecol. Sci., Univ. Occup. Environ. Health, 4)Dept. Pharmacol., Ryukyu Univ. Facul. Med.
Journal of Pharmacological Sciences 121 (suppl) 214-214, 2013.

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P3-12 Brain pericytes contribute to the blood-brain barrier disruption induced by thrombin

Takashi Machida, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Hisayo Takenoshita, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharm. Care Health Sci., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 214-214, 2013.

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P3-13 Adenosine stimulates brain pericytes to release matrix metalloproteinase-9 through A3 adenosine receptor

Makoto Shougakiuchi, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Yui Yamamoto, Haruka Aikawa, Satomi Nagata, Shinya Dohgu, Yasufumi Kataoka
Dept. Pharm. Care. Health Sci., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 215-215, 2013.

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P3-14 Alpha7 nicotinic acetylcholine receptor mediates MMP-9 retease from brain pericytes

Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Noriyuki, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharm. Care Health Sci., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 215-215, 2013.

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P3-15 Prostaglandin E2 induces apoptosis in cultured rat microglia

Takayuki Nagano, Shinya H.KImura, Motohiko Takemura
Dept. Pharmacol., Hyogo Col. Med.
Journal of Pharmacological Sciences 121 (suppl) 215-215, 2013.

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P3-16 Increase in extracellular adenosine level by adenosine metabolic enzyme inhibitors and removal of extracellular Ca2+ in rat spinal astrocytes

Sanae Masumoto, Ken-ichi Otsuguro, Soichiro Yamaguchi, Shigeo Ito
Lab. Pharmacol., Grad. Sch. Vet. Med. Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 215-215, 2013.

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P3-17 Cytokines induce a down-regulation of connexin 43-gap junction in spinal astrocytes

Fangfang Zhang, Norimitsu Morioka, Yoki Nakamura, Kazue Nakashima-Hisaoka, Yoshihiro Nakata
Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 121 (suppl) 216-216, 2013.

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P3-18 Expression analysis of astrocytic Kir4.1 channels in pentylentetrazol-induced kindling model

Takahiro Mukai, Yuki Nagao, Asuka Ono, Yoshihisa Sakagami, Aoi Okuda, Megumi Fujimoto, Saki Shimizu, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 216-216, 2013.

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P3-19 Axonal ATP signaling mediates Schwann cell myelination

Daisuke Ino1), Hiroshi Sagara2), Kazunori Kanemaru1), Yohei Okubo1), Masamitsu Iino1)
1)Dept. Pharmacol., Grad. Sch. Med. Univ. Tokyo, 2)Medical Proteomics Lab., Instit. Med. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 121 (suppl) 216-216, 2013.

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P3-20 Drastic expression of granulocyte macrophage colony-stimulating factor (GM-CSF) by Toll-like receptor 4-activated surviving microglia

Mayumi Kamigaki1), Izumi Hide1), Yuhki Yanase2), Kana Harada1), Takahiro Seki1), Shigeru Tanaka1), Michihiro Hide2), Norio Sakai1)
1)Dept. of Mol. and Pharmacol. Neurosci, Inst of Biomed & Health Sci, Hiroshima Univ., 2)Dept. of Dermatol, Inst of Biomed & Health Sci, Hiroshima Univ.
Journal of Pharmacological Sciences 121 (suppl) 216-216, 2013.

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P3-21 Histamine stimulated phagocytosis of the primary rat microglia

Tomomitsu Iida1),2), Takeo Yoshikawa1), Akihiro Kondo1), Tadaho Nakamura1), Fumito Naganuma1), Ryuichi Harada1), Ren Iwata2), Kazuhiko Yanai1),2)
1)Dept. Pharmacol., Tohoku Univ. Sch. Med., 2)Cyclotron RI Center., Tohoku Univ.
Journal of Pharmacological Sciences 121 (suppl) 217-217, 2013.

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P3-22 Mice lacking prostanoid receptor CRTH2 do not show MK-801-induced cognitive impairment

Takuya Kanoh1), Norihito Shintani1), Yusuke Onaka1), Risa Takenaga1), Ryota Haba1), Atsuko Hayata1),2), Hiroyuki Hirai3), Kinya Nagata3), Masataka Nakamura4), Akemichi Baba5), Hitoshi Hashimoto1),2)
1)Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2)Mol. Res. Cent. Child Ment. Dev., United Grad. Sch. of Child Dev., Osaka Univ., 3)Dept. Advanced Med. and Dev., BML., Inc., 4)Hum. Gene Sci. Cent., Tokyo Med. and Dent. Univ., 5)Pharmaceut. Sci., Hyogo Univ. of Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 217-217, 2013.

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P3-23 A unique effect of lurasidone on the cognitive function in object retrieval with detours, a test of the executive function in non-human primates

Tomokazu Nakako1), Takeshi Murai1), Masaru Ikejiri1), Takeo Ishiyama2), Kazuhito Ikeda1), Mutsuo Taiji2)
1)Ikeda Lab. Dainippon Sumitomo Pharma Co., Ltd., 2)Pharmacol. Research Lab., Dainippon Sumitomo Pharma Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 217-217, 2013.

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P3-24 Effects of modafinil on reward processing in healthy individuals: pharmacological fMRI

Takuya Funayama1), Yumiko Ikeda2), Amane Tateno3), Hidehiko Takahashi4), Yoshiro Okubo3), Haruhisa Fukayama1), Hidenori Suzuki2)
1)Anesthesiol Clin Physiol, Grad Sch, Tokyo Med Dent Univ, 2)Dept Pharmacol, Grad Sch of Med, Nippon Med Sch, 3)Dept Neuropsychiatry, Grad Sch of Med, Nippon Med Sch, 4)Dept Neuropsychiatry, Grad Sch of Med, Kyoto Univ
Journal of Pharmacological Sciences 121 (suppl) 217-217, 2013.

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P3-25 Association between memory impairment and osmolar transporters in the mouse brain after water-immersion restraint stress

Masayuki Hiramatsu1),3), Asako Ogawa1), Yuji Kasugai1), Kiwamu Kido1), Toshitaka Nabeshima1),2)
1)Dept. Chem. Pharmacol., Fac. Pharmac., Meijo Univ., 2)Dept. Region. Pharmac. Care & Sci., 3)Lab. Neuropsychopharmacol., Grad. Sch. Environ. & Human Sci.
Journal of Pharmacological Sciences 121 (suppl) 218-218, 2013.

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P3-26 Effects of perinatal exposure to nonylphenol on the function of central nervous system in male rat offsprings

Shinichiro Kawaguchi1), Rika Kuwahara1), Yumi Kohara2), Haiming Cui2), Takeshi Jojima2), Kimihiro Yamashita1),2)
1)Grad. Sch. Sci. Technol., Nagasaki Univ., 2)Grad. Sch. Fish. Sci. Env. Stu., Nagasaki Univ.
Journal of Pharmacological Sciences 121 (suppl) 218-218, 2013.

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P3-27 Hypothermia and Hyperthermia affect neuronal degeneration, delayed neuronal death, and galectin-3 expression, following transient forebrain ischemia

Kunio Satoh1),3), Masayuki Niwa2), Masaya Nakashima2), Akira Hara1)
1)Dept. Tumor Pathl., Gifu Univ. Grad. Sch. Med., 2)Unit. Grad. Sch. Drug Discov. Med. Info. Sci., Gifu Univ., 3)Pleclinical Safety Res. Lab. Sanplanet
Journal of Pharmacological Sciences 121 (suppl) 218-218, 2013.

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P3-28 L-Citrulline ameliorates decreases in cerebral blood flow in the rat model of migraine with aura

Yuki Kurauchi1), Koichi Mokudai1), Asami Mori1), Kenji Sakamoto1), Tsutomu Nakahara1), Masahiko Morita2), Ayako Kamimura2), Kunio Ishii1)
1)Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 2)KYOWA HAKKO BIO CO., LTD.
Journal of Pharmacological Sciences 121 (suppl) 218-218, 2013.

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P3-29 Intravenous injection of neural progenitor cells attenuates decrease in expression of connexin-43 after cerebral ischemia

Yoshiyuki Moriyama, Norio Takagi, Chisa Itokawa, Kanae Hashimura, Tetsuro Marunouchi, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.
Journal of Pharmacological Sciences 121 (suppl) 219-219, 2013.

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P3-30 Intra cerebral imaging by multimodality after stroke in rats

Kazuya Hokamura1), Yasuhiro Magata2), Mikako Ogawa2), Kazuo Umemura1)
1)Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2)Med. Photonics Res. Ctr., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 219-219, 2013.

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P3-31 Cilostazol protects the BBB against AGE-related ischemia via TGF-β signaling

Shinsuke Nakagawa1),3), Tomonori Takeshita2), Thuy Dhin3), Rie Tatsumi1), Kentaro Hayashi2), Kunihiko Tanaka1), Izumi Nagata2), Masami Niwa1),3)
1)Dept. Pharmacol., Nagasaki Univ., Grad. Sch. Biomed. Sci., 2)Dept. Neurosur., Nagasaki Univ., Grad. Sch. Biomed. Sci., 3)PharmaCo-Cell
Journal of Pharmacological Sciences 121 (suppl) 219-219, 2013.

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P3-32 The involvement of Toll-like receptor 4 in the retinal damage induced by ischemia

Fumiya Ishizuka1), Hiromi Ogishima1), Shinsuke Nakamura1), Kazuhiro Tsuruma1), Hiroyuki Tanaka2), Masamitsu Shimazawa1), Naoki Inagaki2), Hideaki Hara1)
1)Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ., 2)Pharmacol., Dept. Bioact. Mol., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 121 (suppl) 219-219, 2013.

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P3-33 SH3BP5 is essential for Humanin-mediated protection against Alzheimer's disease-relevant toxicity

Yuji Takeshita, Yuichi Hashimoto, Hiroyuki Uchino, Masaaki Matsuoka
Dept. Pharmacol., Tokyo Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 220-220, 2013.

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P3-34 Local cell damage-induced apoptosis analysis on microfluidic system

Risa Kajiyama1), Taku Watanabe2), Yoshikuni Edagawa3), Tetsushi Sekiguchi4), Shuichi Shoji1)
1)Major in Nanosci. and Nanoeng., Waseda Univ., 2)Grad. Sch. of Sci. and Eng., Waseda Univ., 3)Dept. Pharmacol., Teikyo Heisei Univ., 4)Nanotechnology Research Center, Waseda Univ.
Journal of Pharmacological Sciences 121 (suppl) 220-220, 2013.

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P3-35 The involvement of metallothionein in rotenone-induced neurodegeneration in central and peripheral nervous systems

Shinki Murakami1), Ikuko Miyazaki1), Nao Torigoe2), Norio Sogawa3), Masato Asanuma1)
1)Dept. of Brain Sci., Okayama Univ. Grad. Sch. of Med., Dent. & Pharmaceut. Sci., 2)Dept. of Clin. Pharmacy, Okayama Univ. Grad. Sch. of Med., Dent. & Pharmaceut. Sci., 3)Dept. of Dental Pharmacol., Okayama Univ. Grad. Sch. of Med., Dent. & Pharmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 220-220, 2013.

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P3-36 Development of a novel near-infrared fluorescence probe X65 for in vivo detection of amyloid fibrils

Nobuyuki Okamura1), Ryuichi Harada1), Shozo Furumoto1), Takeo Yoshikawa1), Yukitsuka Kudo2), Kazuhiko Yanai1)
1)Dept. Pharmacol., Tohoku Univ. Sch. Med., 2)CRIETO, Tohoku Univ. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 220-220, 2013.

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P3-37 Microsomal prostaglandin E synthase-1 contributes to dopaminergic neurodegeneration in a 6-OHDA lesioned mouse

Yuri Ikeda-Matsuo1), Tomoko Mizoguchi1), Yasuhito Naito1), Satoshi Uematsu2), Shizuo Akira2), Mitsuo Tanabe1), Yasuharu Sasaki1)
1)Lab. Pharmacol., Sch. Pharmac. Sci., Kitasato Univ., 2)Lab. Host Defense, Immunol Front Res Center, Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 221-221, 2013.

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P3-38 Effects of α1-adrenergic receptor antagonists on methamphetamine-induced dopaminergic neurotoxicity in rats

Kazue Kikuchi-Utsumi1), Mami Ishizaka1), Nobuko Matsumura1), Masahiko Watabe1), Koji Aoyama1), Nobuyuki Sasakawa2), Toshio Nakaki1)
1)Dept. Pharmacol., Teikyo Univ. Sch. Med., 2)Dept. Information and Communication Sci., Faculty of Sci. and Technolo., Sophia Univ.
Journal of Pharmacological Sciences 121 (suppl) 221-221, 2013.

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P3-39 Involvement of cannabinoid receptor in light-induced retinal cell death

Tomoyo Imamura, Yuta Ohno, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 121 (suppl) 221-221, 2013.

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P3-40 Neuroprotection by apolipoprotein E-containing lipoproteins against glaucomatous optic neuropathy

Hideki Hayashi
Priority Org. Innov. Excel., Kumamoto Univ.
Journal of Pharmacological Sciences 121 (suppl) 221-221, 2013.

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P3-41 A novel brain penetrable D-amino acid oxidase inhibitor AS2651816-00 ameliorates MK-801-induced cognitive impairment in mice without affecting D-serine concentration in the frontal cortex

Katsuya Harada1), Atsushi Suzuki1), Junko Yarimizu1), Ichiji Namatame2), Mitsuru Hosaka3), Keni Ni1), Nobuya Matsuoka1)
1)Pharmacology Research Labs., Astellas Pharma Inc., 2)Molecular Medicine Research Labs., Astellas Pharma Inc., 3)Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 121 (suppl) 222-222, 2013.

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P3-42 Effect of methylphenidate on L-NAME-induced behavioral impairment in Y-maze task in mice

Fukie Yaoita1), Yuka Nagasawa1), Takayuki Saito1), Kaori Arai1), Asaka Shitamichi1), Masahiro Tsuchiya2), Wataru Nemoto1), Osamu Nakagawasai1), Yuichiro Arai3), Takeshi Tadano1),4), Koichi Tan-No1)
1)Dept. Phamacol., Tohoku Pharmaceutical Univ., 2)Dept. Aiging and Geriatric Dent., Tohoku Univ. Grad. Sch. Dent., 3)Dept. Judotherapy, Faculty of Health Sci., Tokyo Ariake University of Medical and Health Sci., 4)Dept. Environmental Health Sci., Kanazawa Univ. Grad. Sch. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 222-222, 2013.

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P3-43 Possible relationship between Early growth response-1 (Egr-1) downregulation and behavioral abnormality in socially isolated mice

Kinzo Matsumoto, Hirofumi Ouchi, Ryohei Tsushima, Ryo Okada, Hironori Fujiwara
Div. Med. Pharmacol, Univ. Toyama, Inst. Natural Med.
Journal of Pharmacological Sciences 121 (suppl) 222-222, 2013.

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P3-44 Role of glial glutamate transporter, GLAST during the early postnatal period in learning and memory

Masayuki Taniguchi1), Akihiro Mouri1), Hirotake Hida1), Mayu Ukai1), Yukari Waki1), Kiyofumi Yamada2), Norio Ozaki3), Kohichi Tanaka4), Toshitaka Nabeshima5), Yukihiro Noda1)
1)Div. Clin. Sci. Neuropsychopharmcol., Meijo Univ. Grad. Sch. Pharm., 2)Dept. Neuropsychophamcol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 3)Dept. Psychi., Nagoya Univ. Grad. Sch. Med., 4)Dept. Mol. Neurosci. Sch. Biomed. Sci. Tokyo Med. Dent. Univ., 5)Dept. Region. Pharmaceutical Care Sci., Meijo Univ. Fac. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 222-222, 2013.

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P3-45 Antidepressant-like effects of a neurosteroid dehydroepiandrosterone sulfate (DHEAS) in mice

Yumi Sugimoto1), Noriko Tagawa2), Yoshiharu Kobayashi2), Kumiko Saitoh3), Yoshihiro Hotta3), Jun Yamada1)
1)Lab. Pharmacol., Dept. Clin. Pharmacy, Yokohama Coll. of Pharmacy, 2)Dept. Med. Biochem., Kobe Pharm. Univ., 3)Coll. Pharm. Kinjo Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 223-223, 2013.

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P3-46 Effect of tipepidine on c-fos like protein expression in rat medial prefrontal cortex

Ryo Kawahara, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Env. Mol. Health. Sci. Kumamoto Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 223-223, 2013.

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P3-47 Proteomic analysis of mice whole brain after tipepidine treatment

Yuki Terada1), Fumio Soeda1), Shogo Misumi2), Tetsuya Shirasaki1), Kazuo Takahama1)
1)Dept. Env. Mol. Health. Sci. Kumamoto Univ. Grad. Sch. Pharm. Sci., 2)Dept. Pharm. Biochem. Kumamoto Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 223-223, 2013.

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P3-48 The alternation of emotional behavior induced by combination of repeated stress and ovariectomy mediated by GABAergic neuronal dysfunction in mice

Takao Tsukahara1), Masaaki Masuhara1),2), Takahiro Sonomura2), Masanori Uemura2), Tomoaki Sato1)
1)Dept. Pharmacol., Kagoshima Univ. Sch. Dent., 2)Dept. Anat. Oral Sciences., Kagoshima Univ. Sch. Dent.
Journal of Pharmacological Sciences 121 (suppl) 223-223, 2013.

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P3-49 PACAP-heterozygous mutant mice are unsusceptible to chronic social defeat stress

Keisuke Hazama1), Atsushi Kasai1),2), Kaoru Seiriki1), Ryo Okada1), Sumiaki Ogawa1), Atsuko Hayata3), Norihito Shintani1), Akemichi Baba4), Hitoshi Hashimoto1),3)
1)Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2)Interdisciplinary Program for Biomedical Sciences, Institute for Academic Initiatives, Osaka University, 3)United Grad. Sch. of Child Development., Osaka Univ., Kanazawa Univ., and Hamamatsu Univ. Sch. of Med., 4)Sch. of Pharmacy, Hyogo Univ. of Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 224-224, 2013.

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P3-50 Combination Effects of Brexpiprazole (OPC-34712) with SSRI/Diazepam on Marble Burying Behaviour in Mice

Kenji Maeda, Tsuyoshi Hirose, Tetsuro Kikuchi
Qs' research institute, Otsuka Pharmaceutical
Journal of Pharmacological Sciences 121 (suppl) 224-224, 2013.

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P3-51 Juvenile social defeat impairs social behaviors in adult: involvement of glucocorticoid and neurogenesis

Mayu Ukai1), Akihiro Mouri1), Taniguchi Masayuki1), Hirotake Hida1), Yu Ando1), Akira Yoshimi2), Toshitaka Nabeshima3), Norio Ozaki2), Yukihiro Noda1)
1)Div. Clin. Sci. Neuropharmacol., Meijo Univ. Fac. Pharm., 2)Dept. Psychi., Nagoya Univ. Grad. Sch. Med., 3)Dept. Region. Pharmaceutical Care. Sci. Fac. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 224-224, 2013.

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P3-52 RQ-00311651, a novel T-type calcium channel blocker: the inhibitory effects on membrane currents or calcium influx, and analgesic activity

Yuma Kawara1), Fumiko Sekiguchi1), Daiki Kanaoka1), Yudai Kawaishi1), Maho Tsubota-Matsunami1), Shigeru Yoshida2), Tsuyako Ohkubo3), Mio Yamasawa4), Norikazu Gaja4), Hiroyuki Ohshiro4), Tadashi Inoue4), Atsufumi Kawabata1)
1)Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm., 2)Dep. Life Sci., Kinki Univ. Sch. Engineer., 3)Dep. Physiol. Sci. Mol. Biol., Fukuoka Dent. Coll., 4)RaQualia Pharma Inc.
Journal of Pharmacological Sciences 121 (suppl) 224-224, 2013.

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P3-53 Therapeutic effect of RQ-00311651, a novel T-type Ca2+ channel blocker, on distinct visceral pain

Eri Kawakami1), Maho Tsubota-Matsunami1), Tomoka Ozaki1), Fumiko Sekiguchi1), Tadashi Inoue2), Takako Okumura2), Atsufumi Kawabata1)
1)Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm., 2)RaQualia Pharma Inc.
Journal of Pharmacological Sciences 121 (suppl) 225-225, 2013.

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P3-54 Recombinant human soluble thrombomodulin suppresses bladder pain in mice with cyclophosphamide-induced cystitis

Kaoru Yamaguchi1), Junichi Tanaka1),2), Yukari Seki1), Hiroyasu Ishikura2), Maho Tsubota-Matsunami1), Fumiko Sekiguchi1), Atsufumi Kawabata1)
1)Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm., 2)Dept. Emerg. Crit. Care Med., Fac. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 225-225, 2013.

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P3-55 Recombinant human soluble thrombomodulin abolishes HMGB1-dependent inflammatory hyperalgesia in rats

Yukari Seki1), Junichi Tanaka1),2), Kaoru Yamaguchi1), Hiroyasu Ishikura2), Maho Tsubota-Matsunami1), Fumiko Sekiguchi1), Atsufumi Kawabata1)
1)Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm., 2)Dept. Emerg. Crit. Care Med., Fac. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 225-225, 2013.

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P3-56 Cholinesterase inhibitors donepezil and galantamine reduces hypersensitivity in neuropathic pain by the central muscarinic receptors

Kenji Honda, Yuri Matsuda, Mao Yamanoue, Suguru Nakamizo, Noburu Honma, Ryo Saito, Yukio Takano
Dept. Physiol. & Pharmacol., Fac. Pharmaceut. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 225-225, 2013.

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P3-57 Involvement of the chemokine CCL3 in the spinal cord in paclitaxel-induced mechanical allodynia in rats

Ryutaro Ochiishi1), Makoto Tsuda1), Kenichiro Nagata2), Takayuki Yano1), Tomoyuki Inoue1), Hidetoshi Tozaki-Saitoh1), Kazuhide Inoue1)
1)Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2)Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 121 (suppl) 226-226, 2013.

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P3-58 AS1069562, (+)-isomer of indeloxazine, but not duloxetine has curative-like analgesic effect in rat model of streptozotocin-induced diabetic neuropathy

Nobuhito Murai1), Toshiaki Aoki1), Seiji Tamura1), Hiroko Yamamoto1), Nozomu Hamakawa2), Aishi Kimoto1), Yasuhisa Furuichi1), Nobuya Matsuoka1)
1)Dept. Neuroscience, Pharmacology Res. Labs. Astellas Pharma Inc., 2)Dept. Discovery, Drug Metabolism & Pharmacokinetics, Analysis & Pharmacokinetics Res. Labs. Astellas Pharma Inc.
Journal of Pharmacological Sciences 121 (suppl) 226-226, 2013.

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P3-59 AS1069562, (+)-isomer of indeloxazine, is an unique SNRI with a broader analgesic effects: Comparison with duloxetine and amitriptyline

Toshiaki Aoki, Seiji Tamura, Mina Tsukamoto, Toshihiro Sekizawa, Nobuhito Murai, Ryugo Enomoto, Aishi Kimoto, Yasuhisa Furuichi, Nobuya Matsuoka
Dept. Neuroscience, Pharmacology Res. Labs. Astellas Pharma Inc.
Journal of Pharmacological Sciences 121 (suppl) 226-226, 2013.

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P3-60 Involvement of spinal dynorphin in the mechanism of morphine resistance to allodynia after peripheral nerve injury

Takaaki Komatsu1), Soh Katsuyama2), Chikai Sakurada3), Shinobu Sakurada4), Tsukasa Sakurada1)
1)Dept. Pharmacol., Daiichi Coll. Pharmaceu. Sci., 2)Dept. Clinical. Pharmaceutics., Tohoku. Pharmaceu. Univ., 3)Dept. Biochem., Nihon. Pharmaceu. Univ., 4)Dept. Physiol. Anat., Tohoku. Pharmaceu. Univ.
Journal of Pharmacological Sciences 121 (suppl) 226-226, 2013.

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P3-61 Effects of cilnidipine on C-fiber-evoked field potentials in spinal dorsal horn in long-term potentiation and neuropathic pain

Yuma Suzuki, Shohei Yamamoto, Masahiro Ohsawa, Hideki Ono
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 121 (suppl) 227-227, 2013.

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P3-62 Changes in serotonergic modulation of neuronal activity in hippocampus and nucleus accumbens following repeated morphine administrations in rats

Kumatoshi Ishihara, Misato Fujii, Chisato Yoshikawa, Manato Tanabe
Lab. Neuropharmacol., Fac. Pharm. Sci., Hiroshima Intl. Univ.
Journal of Pharmacological Sciences 121 (suppl) 227-227, 2013.

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P3-63 Role of brain-derived neurotrophic factor (BDNF) in the sensitization and conditioned rewarding effects induced by 3,4-methylenedioxymethamphetamine (MDMA) in mice

Akihiro Mouri1), Yukihiro Noda1), Yurie Matsumoto2), Minae Niwa2), Atsumi Nitta3), Kiyofumi Yamada4), Shouei Furukawa5), Toshitaka Nabeshima6)
1)Div. Clin Sci & Neuropsychopharm, Meijo Univ. Sch. Pharm., 2)Dept. Chem Pharm, Meijo Univ. Grad. Sch. Pharm., 3)Dept. Pharm Therapy & Neuropsychopharm, Toyama Univ. Grad. Sch. Pharm., 4)Dept. Neuropsychopharm & Hosp Pharm, Nagoya Univ. Grad. Sch. Med., 5)Lab. Mol Biol, Dept. Biofunc. Anal, Gifu Pharm. Uni., 6)Dept. Region. Pharm. Care & Sci, Meijo Univ. Sch. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 227-227, 2013.

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P3-64 Chronic treatment of ethanol enhanced morphine-induced hyperlocomotion

Kouji Andou, Masahiro Shibasaki, Tomohisa Tsuyuki, Ami Otokozawa, Tomohisa Mori, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Parmaceut. Sci.
Journal of Pharmacological Sciences 121 (suppl) 227-227, 2013.

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P3-65 Functional role of the N-terminal domain of ΔFosB in response to stress and drugs of abuse

Yoshinori Ohnishi1),2), Yoko Ohnishi2), Ezekiell Mouzon2), Vincent Vialou2), Quincey Laplant2), Akinori Nishi1), Eric Nestler2)
1)Dept. Pharmacol., Kurume Univ., 2)Dept. Neurosci., Mount Sinai School of Medicine
Journal of Pharmacological Sciences 121 (suppl) 228-228, 2013.

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P3-66 Involvement of dopaminergic system in stress-induced anticonvulsant effect in juvenile mice

Shuichi Hiroyama1), Masahito Horiuchi1), Kohji Abe2), Tetsuji Itoh1)
1)Drug Safety Evaluation, Drug Develop. Res. Lab., Shionogi & Co., Ltd., 2)Innovative Drug Discovery Technologies, Innov. Drug Discov. Res. Lab., Shionogi & Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 228-228, 2013.

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P3-67 Centrally administered bombesin induces S-nitrosylation of cyclooxygenase-1 in spinally projecting neurons of the hypothalamic paraventricular nucleus in rats

Kenjiro Tanaka, Takahiro Shimizu, Kumiko Nakamura, Kunihiko Yokotani
Dept. Pharmacol., Sch. of Medicine, Kochi Univ.
Journal of Pharmacological Sciences 121 (suppl) 228-228, 2013.

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P3-68 Daily rhythm in the cell mitosis of the adult mouse hippocampal neural progenitor cells

Takahiro Moriya1), Tomoko Maekawa1), Tokiko Suzuki1), Noriko Osumi2), Norimichi Nakahata1)
1)Dept. Cell. Signal., Grad. Sch. Pharm. Sci., Tohoku Univ., 2)Grad Sch Med, Tohoku Univ.
Journal of Pharmacological Sciences 121 (suppl) 228-228, 2013.

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P3-69 Effects of cholinesterase inhibitors and serotonin 5-HT1A receptor agonists on morphine-induced ventilatory depression and analgesia

Satoko Kimura, Shiho Mizuno, Shiori Yamaguchi, Yoshiaki Ohi, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 229-229, 2013.

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P3-70 Examining the roles of hypoxia inducibie factor-1α in HCA-7 human colon cancer cells

Sho Otake1), Hiromichi Fujino1), Kenji Yoshida1), John.W.Regan2), Toshihiko Murayama1)
1)Lab. Chemical Pharmacol., Grad. School of Pharmaceutical Sci., Chiba Univ., 2)Dept. Pharm/Tox, College of Pharmacy, The Univ. of Arizona
Journal of Pharmacological Sciences 121 (suppl) 229-229, 2013.

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P3-71 Secretion of glucagon-like peptide-1 from intestinal L cell in hypoxia

Mari Itoh1), Yoshitaka Kihira1), Noriko Yamano1), Yuki Ishizawa1), Keisuke Ishizawa2), Yasumasa Ikeda1), Koichiro Tsuchiya2), Shuhei Tomita3), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 2)Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 3)Div. Mol. Parmacol., Fac. Med., Tottori Univ.
Journal of Pharmacological Sciences 121 (suppl) 229-229, 2013.

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P3-72 Activation of GPR174 induces morphological changes and proliferation delay via increasing intracellular cAMP in CHO cells

Norihisa Fujita1),2), Kazuya Sugita1), Chiaki Yamamura1), Ken-ichi Tabata1)
1)Life Sci., Grad. Sch., Ritsumeikan Univ., 2)Ritsumeikan Univ. Sch. of Pharm.
Journal of Pharmacological Sciences 121 (suppl) 229-229, 2013.

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P3-73 Involvement of M2 or M3 muscarinic receptor-coupled signalling molecules in the activation of muscarinic cation channels in mouse ileal smooth muscle cells

Toshihiro Unno1), Taisuke Katsurada1), Hayato Matsuyama1), Yasuyuki Tanahashi2), Takio Kitazawa3), Masahisa Yamada4), Yurgen Wess5)
1)Dept. Vet. Gifu Univ., 2)Dept. Animal Med. Sci., Kyoto Sangyo Univ., 3)Dept. Vet. Med., Rakuno Gakuen Univ., 4)Common Resources Group, Okinawa Inst. Sci. Tech., 5)Lab. Bioorganic Chem., NIHNIDDKD
Journal of Pharmacological Sciences 121 (suppl) 230-230, 2013.

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P3-74 Pivotal role of cellular Ca2+ in carbachol-induced contraction of the isolated rat colon

Hiromi Nobe1), Yashushi Sakai1), Koji Nobe2), Yukisato Ishida1)
1)Fac. Health Sci. Tech., Bunkyo Gakuin Univ., 2)Lab. of Physiol., Facult. Pharm., Sci., Josai Univ.
Journal of Pharmacological Sciences 121 (suppl) 230-230, 2013.

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P3-75 Genome-Wide Screening Reveals Npr2 Positively Regulates Tor2 in Fission Yeast

Yan Ma, Ning Ma, Qingbin Liu, Lili Zhang, Hisatomo Fukuma, Kazuto Nishijima, Takayoshi Kuno
Dept. Pharmacol., Kobe Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 230-230, 2013.

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P3-76 A new ceramide analog as a golgi marker with no cytotoxicity

Tomohiko Makiyama1), Takuya Honda2), Hiroyuki Nakamura1), Atsushi Nishida3), Naoto Yamaguchi2), Toshihiko Murayama1)
1)Laboratory of chemical, pharmacology, 2)Laboratory of Molecular Cell Biology, 3)Laboratory of organic chemistry
Journal of Pharmacological Sciences 121 (suppl) 230-230, 2013.

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P3-77 Do paclitaxel and gemcitabine exacerbate pulmonary fibrosis in a BLM-induced pulmonary fibrosis mouse model?

Yukiko Kawasaki, Yasushi Hirasawa, Rina Yamamoto, Shoko Otsu, Takahiro Sugiura, Yukari Matsui, Takahito Imaizumi, Jun Imai, Tohru Toyoshi, Kohei Kyuki
Nihon Bioresearch Inc.
Journal of Pharmacological Sciences 121 (suppl) 231-231, 2013.

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P3-78 Chronic olanzapine treatment exacerbates glucose intolerance in mice

Keiichiro Inui1),2), Hiroko Sugimoto2), Yusuke Murata2), Yasushi Mizuki1), Kazunori Mine2)
1)Shimonoseki Hospital of mental and Nervous Disorders, 2)Fukuoka University Department of Psychosomatic Medicine Faculity of Pharmaceutical Sciences
Journal of Pharmacological Sciences 121 (suppl) 231-231, 2013.

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P3-79 Tissue taurine depletion enhanced glucose disposal and results in resistance to high fat diet-induced type2 diabetes and steatohepatitis

Takashi Ito, Junichi Azuma
Dept. Pharmacy., Hyogo Univ. of Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 231-231, 2013.

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P3-80 Small and interfering RNA targeting apelin promotes recruitment of pericyte to retinal newly formed vessels via up-regulation of MCP-1 expression

Yuki Ishimaru1), Atsushi Kasai2),3), Kosuke Higashino1), Akiko Yamamuro1), Yasuhiro Yoshioka1), Sadaaki Maeda1)
1)Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., 2)Interdisciplinary Program for Biomedical Sci., Institute for Academic Initiatives, Osaka Univ., 3)Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ.
Journal of Pharmacological Sciences 121 (suppl) 231-231, 2013.

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P3-81 Development of a high performance RNAi library and its application to cell-based functionai screening for genes regulating intracellular calcium signaling

Isamu Taikou, Kenzo Hirose
Dept. Neurobiol., Tokyo Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 232-232, 2013.

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P3-82 High throughput screening system for development of anti-cancer drugs inducing HER2 internalization

Masayuki Isa1), Daisuke Asanuma1), Shigeyuki Namiki1), Kazuo Kumagai2), Hirotatsu Kojima2), Tajayoshi Okabe2), Tetsuo Nagano2), Kenzo Hirose1)
1)Dept. Neurobiol., Tokyo Univ. Sch. Med., 2)OCDD., Tokyo Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 232-232, 2013.

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P3-83 Microbubble fluids as tissue oxygen delivery system

Yoko Ochiai1), Noriaki Matsuki2)
1)3rd Department of Anesthesiology & Intensive Care Medicine, 2)Department of Biomedical Engineering, Okayama University of Science
Journal of Pharmacological Sciences 121 (suppl) 232-232, 2013.

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P3-84 Effects of peripheral metabotropic glutamate receptor type 1/5 for TRPV1 channel activity and expression in mouse dorsal root ganglion

Takayoshi Masuoka1), Tadayuki Nakamura1), Junko Yoshida1), Yuki Takaoka1), Noriko Imaizumi1), Takaharu Ishibashi1),2), Matomo Nishio1)
1)Dept. Pharmacol., Kanazawa Med. Univ., 2)Pharmacol. Sch. Nurs., Kanazawa Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 232-232, 2013.

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P3-85 An analgesic drug tramadol selectively modulates the activity of TRPA1 but not TRPV1

Kanako Miyano1), Kouichiro Minami1),2), Toru Yokoyama1), Katsuya Ohbuchi3), Masahiro Yamamoto3), Seiji Shiraishi1), Motohiro Matoba4), Yasuhito Uezono1)
1)Cancer Pathophysiol. Div., NCCRI., 2)Emergency Life-Saving Technique Academy of Tokyo, 3)Tsumura Research Labs, Tsumura & Co., 4)Dept. Palliative Med., NCCH.
Journal of Pharmacological Sciences 121 (suppl) 233-233, 2013.

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P3-86 The enhanced effect of losartan on parasympathetic neurotransmission of urinary bladder in pithed rats

Fumiko Yamaki, Manami Goukon, Hiroki Sato, Kuniaki Hoshi, Yukihiko Tamashiro, Yoshinobu Takaka
Dept. Pharmacol. Ohu Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 233-233, 2013.

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P3-87 Effect of selective estrogen receptor modulators on the function of bovine adrenal medullary cells

Hirohide Inagaki1), Yumiko Toyohira1), Go Obara4), Keita Takahasihi1), Kojiro Takahashi3), Toru Hachisuga2), Nobuyuki Yanagihara1)
1)Dept. Pharmacol., UOEH, Med., 2)Dept. OBGY, UOEH, Med., 3)Dept. Pharmacol., UOEH, Hosp., 4)Dept. Anesth., UOEH, Med.
Journal of Pharmacological Sciences 121 (suppl) 233-233, 2013.

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P3-88 Studies on pathomechanisms of demyalination caused by the mutation of SIMPLE, the causative gene for CMT1C

Tomohiro Ishii1),2), Yasuhiro Moriwaki1), Kazuhiko Watabe2), Hidemi Misawa1)
1)Dept. Pharmacol., Keio Univ. Fac. Pharm., 2)ALS/Neuropathy Project, Tokyo Met. Inst. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 233-233, 2013.

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P3-89 Transcriptional regulation of transient receptor potential ankyrin 1 channel gene expression by hypoxia inducible factor-1 α

Noriyuki Hatano1), Yuka Itoh2), Hiroka Suzuki1), Yukiko Muraki1), Hidetoshi Hayashi2), Kikuo Onozaki3), Ian Wood4), David Beech4), Katsuhiko Muraki1)
1)Lab. Cellular Pharmacol. Sch. Pharm., Aichi-gakuin Univ., 2)Dept. Drug Metab. Dispos., Grad. Sch. Pharmaceut. Sci. Nagoya City Univ., 3)Dept. Mol. Health Sci., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 4)Inst. of Membrane and Systems Biol., Garstang Building, Fac. of Biol. Sci., Univ. of Leeds
Journal of Pharmacological Sciences 121 (suppl) 234-234, 2013.

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P3-90 A pathogenic role of TRPM2 in a murine model of rheumatoid arthritis

Daisuke Kozai1), Yuji Kaneko2), Tomohide Isobe3), Tetsuhiko Tachikawa3), Ryutaro Kamijo4), Shunichi Shimizu2), Yasuo Mori1),5)
1)Kyoto Univ., Dept. Synthet. Chem. & Biol. Chem., Grad. Sch. Engineer., 2)Showa Univ., Sch. Pharmaceut. Sci., Dept. Pathophysiol., 3)Showa Univ., Sch. Dent., Dept. Oral Pathol. & Diag., 4)Showa Univ., Sch. Dent., Dept. Biochem., 5)Kyoto Univ., Dept. Technol. & Ecol.
Journal of Pharmacological Sciences 121 (suppl) 234-234, 2013.

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P3-91 Isolation of HSP72-binding protein in the serum

Ryo Uemura1), Masako Tanaka1), Satoshi Nishi1), Masako Kawaguchi1), Yasuyuki Ohkawa2), Hedeki Wanibuchi3), Yasukatsu Izumi1), Katsuyuki Miura4), Masayuki Shiota1), Hiroshi Iwao1)
1)Dept. Pharmacol., Osaka City Univ. Grad. Sch. Med., 2)Div. Epigenetics, Kyushu Univ. Grad. Sch. Med., 3)Dept. Pathol., Osaka City Univ. Grad. Sch. Med., 4)Appl. Phrmacol. Ther., Osaka City Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 234-234, 2013.

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P3-92 Analysis of genetic alteration in LAT1 knockdown human scirrhous gastric carcinoma cell line

Keitaro Hayashi1), Hitoshi Endou2), Naohiko Anzai1)
1)Dept. Pharmacol. and Toxicol., Dokkyo Med. Univ., Sch. Med., 2)J-Pharma Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 234-234, 2013.

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P3-93 Combination treatment with bisphosphonates and statins shows a synergistic antitumor effect on a pancreatic cancer in vitro

Yuko Yoshizawa
Dept. Clinic Pharm. and Pharmaceut. Care, Grad. Sch. Pharmaceut. Sci., Kyushu University
Journal of Pharmacological Sciences 121 (suppl) 235-235, 2013.

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P3-94 Enhancement by anthracyclines of antitumor potential of benzaldehyde derivatives against human oral squamous Cell Carcinoma Cell lines

Tetsufumi Sano1),2),3), Jun Shimada2), Jun Saitoh3), Atsuko Kochi3), Masahiro Sugimoto4), Masaru Tomita5), Hiroshi Sakagami1)
1)Div. Pharm., Meikai Univ. Sch. Dent., 2)Div. 1st Oral Maxilofacial Surgery, 3)Ichijokai Hospital, 4)Kyoto Univ. Sch. Med., 5)Inst. Adv. Biosci., Keio Univ.
Journal of Pharmacological Sciences 121 (suppl) 235-235, 2013.

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P3-95 Analysis of miRNA expressions in Breast Cancer

Kentaro Yatomi1), Akiko Sasaki1), Mayumi Tsuji1), Yuko Udaka1), Yuko Tsunoda2), Katsuji Oguchi1)
1)Dept. Pharmacol. Showa-Univ. Sch. Med., 2)Dept. beast-surgery. Showa-Univ. hospital.
Journal of Pharmacological Sciences 121 (suppl) 235-235, 2013.

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P3-96 Antitumor effect of nerve growth factor (NGF) on human carcinoma cell involves innervations and maturation of tumor neovasculature

Shingo Takatori, Satoko Fukuhara, Rikiya Shiwaku
Dept. Clin. Pharm. Sci., Grad. Sch. Med., Dent. Pharm. Sci., Okayama Univ.
Journal of Pharmacological Sciences 121 (suppl) 235-235, 2013.

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P3-97 Tumor suppression by GSK-3β activator DIF-1 in colorectal and xenografted cancer model mice

Fumi Takahashi, Toshiyuki Sasaguri
Dept. Clinical Pharmacology., Fac. med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 236-236, 2013.

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P3-98 Inhibitory effect of fucoidan in the proliferation of tumor cells

Nobufumi Ono, Yuta Jitsuzaki, Masahiko Kimura, Kazushi Kushiku
Med. Inf & Res. Unit, Fac. Pharmaceut. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 236-236, 2013.

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P3-99 Ghrelin resistance in a novel cancer cachexia model and its effects of rikkunshito by enhancement of ghrelin signaling

Kiyoshi Terawaki1),4), Yohei Kashiwase1),3), Yumi Sawada1), Masami Suzuki1), Kanako Miyano1), Yuka Sudo1), Seiji Shiraishi1), Yoshikazu Higami3), Yoshio Kase4), Kazuyoshi Yanagihara2), Yasuhito Uezono1)
1)Div. Cancer Pathophysiol., NCCRI, 2)Div. Genetics, NCCRI, 3)Lab. Mol. Pathology and Metabolic disease, Faculty Pharm. Sci., Tokyo Univ. Sci., 4)Tsumura Res. Lab., Tsumura & Co.
Journal of Pharmacological Sciences 121 (suppl) 236-236, 2013.

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P3-100 Study of combination effect of alkaline extract of leaves of Sasa senanensis Rehder, antibacterial agent and charcoal aiming at manufacturing toothpaste

Hiroshi Sakagami1), Kazue Satoh1),2), Shigeru Amano3), Toshikazu Yasui4), Taisei Kanamoto5), Shigemi Terakubo5), Hideki Nakashima5), Madoka Kitajima6), Tomoko Sugiura6), Koichi Watanabe7), Hiroshi Oizumi6), Takaaki Oizumi6)
1)Div. Pharmacol., Meikai Univ. Sch. Dent., 2)Dept. Anatomy, Sch. Med., Showa Univ., 3)Div. Microbiol., Meikai Univ. Sch. Dent., 4)Div. Oral Health, Meikai Univ. Sch. Dent., 5)Dept. Microbiol., St. Marianna Univ., 6)Daiwa Biol. Res. Inst. Co., Ltd., 7)Sampo Pharm. Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 236-236, 2013.

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P3-101 San'o-shashin-to, a Kampo Medicine, Ameliorates Cardiac Ischemia/Reperfusion Injury in Ovariectomized Rats via Suppression of Peroxynitrite Formation and Restoration of Manganese Superoxide Dismutase Activities

Mayuko Sakanashi1), Toshihiro Matsuzaki1), Katsuhiko Noguchi1), Junko Nakasone1), Taro Uchida1), Mika Tanada1), Haruaki Kubota1),2), Makiko Sakanashi2), Matao Sakanashi1), Kazuhiro Sugahara2), Masato Tsutsui1)
1)Dept. Pharmacol., Grad. Sch. Med., Univ. of the Ryukyus, 2)Dept. of Anesth., Grad. Sch. Med., Univ of the Ryukyus
Journal of Pharmacological Sciences 121 (suppl) 237-237, 2013.

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P3-102 Extracts of curry plant increase blood flow of extremities in rats

Naoya Kosuga1), Nobuo Uotsu2), Tatsuya Kon2), Sachiyuki Teramoto2), Kensuke Orito1)
1)Dept. Physiol II, Azabu Univ. Sch. Vet Med., 2)FANCL Corporation FANCL Research Institute
Journal of Pharmacological Sciences 121 (suppl) 237-237, 2013.

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P3-103 Effects of Protamine-Hydrolysate Peptides (DMX) on wound healing in an experimental rat skin wound healing model

Noboru Kuboyama1), Shigetoshi Okumura2), Hitoshi Tamura3), Hitoshi Yamamoto4)
1)Depart. Pharmacol., Nihon Univ. Sch. Dentistry at Matsudo, 2)Rohto Pharmaceutical Co., LTD., 3)Tamura Dental Office, 4)Depart. Ultrastruct. Sci., Tokyo Dent. College
Journal of Pharmacological Sciences 121 (suppl) 237-237, 2013.

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P3-104 Effects of ω-3 and ω-6 fatty acid supplementation on regulation of blood glucose in mice

Yukiko Naito, Xiao Ma, Kosuke Endo, Xu Ji, Huachun Weng, Naoharu Iwai
Dept. Genomic Med., NCVC
Journal of Pharmacological Sciences 121 (suppl) 237-237, 2013.

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P3-105 Sex difference of the adverse effects induced by canola oil ingestion in stoke-prone spontaneously hypertensive rats (SHRSP)

Chihiro Anma1), Mai Takamatsu1), Mai Yoshikawa1), Madoka Niimi1), Maho Kawaguchi1), Yukiko Naito2), Shigehiro Tachibana3), Naoki Ohara1), Harumi Okuyama1)
1)Safety Evaluation, Kinjo Gakuin Univ. Coll. Pharm., 2)Dept. Genom. Med., Ntl. Cerebral & Cardiovasc. Ctr, Res. Inst., 3)FDSC, Div. Toxicol.
Journal of Pharmacological Sciences 121 (suppl) 238-238, 2013.

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P3-106 Drinkable preparation of Theracurmin exhibits high absorption efficiency

Tatsuya Morimoto1),2),5), Yoichi Sunagawa1),5), Yasufumi Katanasaka1),5), Sae Hirano1), Masatoshi Namiki1), Yuichi Watanabe1), Osamu Doi2), Tsunehiro Yokochi2), Yoshihiko Otsuka3), Tomoko Hamada3), Atsushi Imaizumi3), Yuji Nonaka4), Hiromichi Wada5), Koji Hasegawa5)
1)Div. Mol. Med., Sch. Pharm. Sci., Univ. of Shizuoka, 2)Div. of Cardiovascular Medi., Shizuoka General Hospi., 3)THERAVALUES CORPO., 4)Suntory Beverage & Food Limited, 5)Div. of Translational Res., Kyoto Medi. Cent., National Hospi. Organization
Journal of Pharmacological Sciences 121 (suppl) 238-238, 2013.

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P3-107 Effects of flavonoids on proliferation of vascular smooth muscle cells and the contractile response

Yoshiko Tokutomi1), Yukari Koga1), Atsuko Sakata1), Naofumi Tokutomi2)
1)Dept. Nutr. Sci., Shokei Univ., 2)Dept. Pharmacol., Grad. Sch. Pharm. Sci., Sojo Univ.
Journal of Pharmacological Sciences 121 (suppl) 238-238, 2013.

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P3-108 The influence of foods/beverages on rhodamine123 transport in caco-2 cell monolayers

Yurika Morita, Katsuyoshi Sunaga, Atsuko Ohkubo, Tadashi Tsuda
Dept. Cli. Diet. Hum. Nutr., Josai Univ.
Journal of Pharmacological Sciences 121 (suppl) 238-238, 2013.

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P3-109 Effects of cigarettes smoke on branched chain amino acids (BCAA) levels in plasma and skeletal muscles in rats

Kaoru Kubo1), Koichi Tomoda2), Masanori Yoshikawa2), Noriko Koyama2), Keiji Yamamoto2), Hiroshi Kimura2)
1)Lab. Animal. Res., 2)Second Dep. Int. Med.
Journal of Pharmacological Sciences 121 (suppl) 239-239, 2013.

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P3-110 Examination on the conditions for preparation of a dehydromonocrotaline (DHMCT)-induced pulmonary hypertension model in dogs

Yoshizo Fukuda, Takumi Isomura, Mikito Kikumori, Hironobu Ikeda, Hiroshi Sakonjo
NISSEI BILIS Co., Ltd., Shiga Laboratory
Journal of Pharmacological Sciences 121 (suppl) 239-239, 2013.

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P3-111 Cilnidipine suppresses angiotensin II-induced vascular endothelial dysfunction via N-type calcium channel blockade action

Motohiro Nishida1), Tatsuya Ishikawa2), Sunggip Caroline1), Shizuka Aritomi2), Yasuo Mori3), Shokei Kim-Mitsuyama4)
1)Dept. Drug Discov. Evol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2)Ajinomoto Pharm. Co. Ltd., 3)Grad. Sch. of Envir. Stud., Kyoto Univ., 4)Dept. Pharm. Mol. Therap., Kumamoto Univ. Grad. Sch. of Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 239-239, 2013.

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P3-112 Orthovanadate-induced vasoconstriction of rat aorta is mediated by the Src/EGFR/ROCK pathway

Katsutoshi Yayama, Tomoya Sasahara, Ayaka Funasaka, Shinsaku Haramoto, Hiroshi Okamoto
Lab. of Cardiovascular Pharmacol., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 121 (suppl) 239-239, 2013.

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P3-113 Fatty acid binding protein 4 (FABP4) increases blood pressure via enhancing peripheral arterial resistance in rats

Hideyuki Yamawaki, Taisuke Kogane, Kyosuke Kazama, Muneyoshi Okada, Yukio Hara
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med. Sci.
Journal of Pharmacological Sciences 121 (suppl) 240-240, 2013.

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P3-114 Salivary ion channels as a biomarker of hypertension

Tomasz Pieczonka, Di Wang, Yasuko Ishikawa
Dept. of Pharmacol, Tokushima Univ. Sch. Oral Sci.
Journal of Pharmacological Sciences 121 (suppl) 240-240, 2013.

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P3-115 The influence of angiotensin II on duodenal iron absorption

Soichiro Tajima1),2), Yasumasa Ikeda1), Koichiro Tsuchiya3), Yuya Horinouchi1),2), Takumi Sakurada1),2), Yoshitaka Kihira1), Yuki Ishizawa1), Keisuke Ishizawa3), Kazuyoshi Kawazoe2), Kazuo Minakuchi2), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Healthbiosciences, Univ. Tokushima Grad. Sch., 2)Dept. Pharm., Univ. Tokushima, Hosp., 3)Dept. Medical Pharmacol., Inst. Healthbiosciences, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 240-240, 2013.

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P3-116 Involvement of PKCε-dependent ADAM17 activation in PAR1-mediated ERK phosphorylation in rat cardiomyocytes

Hitomi Otani, Tomoyuki Nakamura
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 121 (suppl) 240-240, 2013.

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P3-117 TRPC3 contributes pressure overload-induced cardiac fibrosis

Naoyuki Kitajima1), Shigeki Kiyonaka2), Yasuo Mori2), Motohiro Nishida1)
1)Dept. Drug. Discov. and Evol., Grad. Sch. of Pharm. Sci., Kyushu Univ., 2)Dept. Synthet. Chem. and Biol. Chem., Kyoto Univ., Grad. Sch. of Engn.
Journal of Pharmacological Sciences 121 (suppl) 241-241, 2013.

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P3-118 Cytosolic Ca2+-induced cardiomyocyte apoptosis through mitochondrial nitric oxide-cGMP-protein kinase G pathway in rat

Kazuhiko Seya1), Kyoichi Ono2), Fujisawa Susumu2), Ken Okumura3), Shigeru Motomura1), Ken-Ichi Furukawa1)
1)Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med., 2)Dept. Cell Physiol., Akita Univ. Grad. Sch. Med., 3)Dept. Cardiol. Hirosaki Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 241-241, 2013.

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P3-119 Possible involvement of phosphorylated heat shock factor-1 in changes in HSP72 induction of the rat failing heart following myocardial infarction

Tetsuro Marunouchi, Mao Murata, Masato Araki, Norio Takagi, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.
Journal of Pharmacological Sciences 121 (suppl) 241-241, 2013.

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P3-120 Pimobendan has a preventive effect on compensated heart failure but increases the risk of sudden cardiac death at end-stage heart failure

Miki Nonaka, Sachio Morimoto, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 121 (suppl) 241-241, 2013.

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P3-121 Introduction of a new method of evaluation of myocariai infarction in micro mini pig using biochemical findings and the real-time ultrasound system

Yuuji Murata, Ryoji Mizumachi, Kazuaki Sasaki, Namie Beppu, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Mitsubishi Chemical Medience Co., ltd.
Journal of Pharmacological Sciences 121 (suppl) 242-242, 2013.

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P3-122 Age-related changes in the aorta of PHT rabbits

Saki Matsumoto1), Fumiaki Nasu1), Shintaro Ono1), Yumi Katano2), Akira Ishihata2), Saori Hishinuma3), Tsunetaka Ito4), Yohei Abe1), Yoshimi Shimizu1)
1)Yamagata Univ. Grad. Sch. Med., 2)Div. Theoretical Nursing and Pathophysiology, 3)Tokyo Univ., Hospital, 4)Lab. Animal Ctr., Sch. Med., Yamagata Univ.
Journal of Pharmacological Sciences 121 (suppl) 242-242, 2013.

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P3-123 Pravastatin normalizes endothelium-derived contracting factor (EDCF)-induced response by suppression of Rho-kinase signalling in superior mesenteric artery from aged type 2 diabetic rat

Keiko Ishida, Takayuki Matsumoto, Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst. Med. Chem. Hoshi Univ.
Journal of Pharmacological Sciences 121 (suppl) 242-242, 2013.

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P3-124 Inhibition of TRPC6 improves peripheral circulatory disturbance by promoting arteriogenesis

Masaaki Sumita1), Shota Saiki2), Yoji Sato3), Michio Nakaya2), Takahiro Iwamoto4), Hitoshi Kurose2), Motohiro Nishida1)
1)Dept. Drug Disc. & Evol., Grad. Sch. of Pharm. Sci, Kyushu Univ., 2)Dept. Pharmacol. & Toxicol., Grad. Sch. of Pharm. Sci, Kyushu Univ., 3)Nat. Inst. of Health Sci., 4)Dept. Pharmacol., Sch. of Med., Fukuoka Univ.
Journal of Pharmacological Sciences 121 (suppl) 242-242, 2013.

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P3-125 Outside fibroblasts play a key role in the development of inner neointima after the implantation of PTFE grafts

Denan Jin, Shinji Takai, Mizuo Miyazaki
Departments of Pharmacology, Osaka Medical College
Journal of Pharmacological Sciences 121 (suppl) 243-243, 2013.

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P3-126 Hypoxia-inducible factor-1α in vascular smooth muscle cells contributes to AT1 receptor expression in angiotensin II-induced vascular remodeling in mice

Masaki Imanishi1), Shuhei Tomita1),2), Keisuke Ishizawa3), Yoshitaka Kihira1), Yasumasa Ikeda1), Noriko Yamano1), Yuki Ishizawa1), Koichiro Tsuchiya3), Toshiaki Tamaki1)
1)Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch., 2)Div. Mol. Parmacol., Fac. Med., Tottori Univ., 3)Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 121 (suppl) 243-243, 2013.

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P3-127 Impaired β-adrenoceptor-mediated relaxation in mesenteric arteries from DOCA-salt hypertensive rats is due to reduced Kca channel activity

Takayuki Matsumoto1), Theodora Szasz2), Tostes Rita C.3), Webb R.Clinton2)
1)Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ., 2)Dept. Physiol., Geogia Health Sci. Univ., 3)Dept. Pharmacol., School of Med. Ribeirao Preto, Univ. Sao Paulo
Journal of Pharmacological Sciences 121 (suppl) 243-243, 2013.

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P3-128 The relationship between insufficient coagulation control and production of coagulation-related factors in patients following prosthetic valve replacement

Kazuo Nakamura1), Harunobu Iwase1), Shigeru Oiso2), Hiroko Kariyazono2)
1)Dept. Biopharma., Nihon Pharmaceutical Univ., 2)Dep. Pharm. Facul. Pharma. Sci. Nagasaki International Uni.
Journal of Pharmacological Sciences 121 (suppl) 243-243, 2013.

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P3-129 Identification of a nifedipine-insensitive high voltage-activated calcium channel widely distributed in mesenteric arterioles

Hiromitsu Morita1), Shohei Yoshimoto1),2), Kihachiro Abe1), Masato Hirata2), Ryuji Inoue3), Yushi Ito4)
1)Special Patient Oral Care Unit, Kyushu Univ. Hosp., 2)Lab. of Mol. Cell. Biochem., Fac, of Dent. Sci., Kyushu Univ., 3)Dept. of Physiol., Grad. Sch. of Med. Sci., Fukuoka Univ., 4)Dept. of Health Sci., Kumamoto Health Sci. Univ.
Journal of Pharmacological Sciences 121 (suppl) 244-244, 2013.

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P3-130 Comparing investigation of phenotypic change between A10 cell and primary rat aortic vascular smooth muscle cell by cyclic strain and stimulation of vasoactive substances

Yukiko Kondo, Naoko Matsushita, Yasuyuki Irie, Eiichi Taira
Dept. Pharmacol., Iwate Medical Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 244-244, 2013.

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P3-131 A novel function of myosin light chain kinase in vascular smooth muscle

Akio Nakamura1), Atsushi Matsumoto1), Wang Hong Hui1), Xie Ce1), Yoshiyama Shinji1), Kawaharada Ritsuko2), Gao Ying3), Ishikawa Ryoki4), Kohama Kazuhiro1)
1)Dept. Mol. Pharmacol and Oncol., Gunma Univ. Sch. Med., 2)Dept. of Health and Nutri., Takasaki Univ. of Health and Welf., 3)Dept. of Biochem., Dalian Univ. of Med., 4)Sch. Nursing, Gunma Pref. Coll. Health Sci.
Journal of Pharmacological Sciences 121 (suppl) 244-244, 2013.

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P3-132 Na+/H+ Exchanger inhibitor induces vasorelaxation through NO production in endothelial cells via intracellular acidification-associated Ca2+ mobilization

Tomoya Sasahara1), Katsutoshi Yayama1), Hiroshi Okamoto1), Toshihiro Matsuzaki2), Masato Tsutsui2)
1)Lab. Cardiovascular Pharmacol., Kobe Gakuin Univ., 2)Lab..Pharmacol., Ryukyu Univ.
Journal of Pharmacological Sciences 121 (suppl) 244-244, 2013.

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P3-133 Mechanisms underlying impaired contractility in serum-free organ-cultured rat mesenteric artery

Tomoka Morita, Muneyoshi Okada, Yukio Hara, Hideyuki Yamawaki
Lab of Vet Pharmacol, Kitasato Univ.
Journal of Pharmacological Sciences 121 (suppl) 245-245, 2013.

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P3-134 Role of β3-adrenoceptors in the regulatory mechanism of retinal vascular tone in rats

Asami Mori, Tsutomu Nakahara, Yuki Kurauchi, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 121 (suppl) 245-245, 2013.

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P3-135 The intracellular domain of the P2X7 receptor subunit participates in agonist operation of the channel

Keisuke Migita, Junko Yamada, Yoshikazu Nikaido, Shinya Ueno
Dept. Neurophysiol., Hirosaki Univ. Sch. Med.
Journal of Pharmacological Sciences 121 (suppl) 245-245, 2013.

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P3-136 11beta-hydroxysteroid dehydrogenase type 1 inhibitor, HIS-601 ameliorates insulin resistance in diet-induced obese mice

Seiji Okazaki, Tomokatsu Iwamura, Takehiro Takahashi, Akiko Izawa, Shoichi Itaba, Chifumi Inada, Kanako Serizawa, Satoshi Sakami, Koji Kawai, Mie Kainoh
Pharmaceutical Research Laboratories, Toray Industries
Journal of Pharmacological Sciences 121 (suppl) 245-245, 2013.

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P3-137 Pharmacological actions of ivermectin on insulin secretion by mouse pancreatic islets

Masahiro Ohtani, Kiyoshi Ohura
Dept. Pharmacol., Osaka Dental Univ.
Journal of Pharmacological Sciences 121 (suppl) 246-246, 2013.

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P3-138 Functional analysis of Nse1/Nse3/Nse4 protein complex related to a neurodevelopmental disease

Naoya Tanabe, Yumi Bando, Hideo Taniura
Lab. Neurochem., Dept. Pharmacy, Ritsumeikan Univ.
Journal of Pharmacological Sciences 121 (suppl) 246-246, 2013.

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P3-139 Identification of Streptococcus sobrinus dextran-binding lectin gene homologs, dblA and dblB in Streptococcus criceti

Haruki Tamura, Arisa Yamada, Hirohisa Kato
Div. of Bioregulatory Pharmacol., Dep. of Pharmacol., Iwate Medi. Uni.
Journal of Pharmacological Sciences 121 (suppl) 246-246, 2013.

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P3-140 Reexamination of histochemical staining of mast cells with basic dyes

Takeshi Kiyoi1),2), Kazutaka Maeyama1)
1)Dep. of Pharmacol. Informational Biomedicine, Ehime Univ. Grad. Sch. of Med., 2)Integrated Center for Science, Ehime Univ.
Journal of Pharmacological Sciences 121 (suppl) 246-246, 2013.

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P3-141 Improve method to evaluate adaptive relaxation (accommodation) using Barostat in rats without surgical operation and the effects of capsaicin and Nω-nitro-L-arginine methylester

Masayuki Uchida, Kimiko Shimizu, Chizuru Iwamoto, Orie Mogami
Food Science Research Laboratories, Division of Research and Development. Meiji Co., Ltd.
Journal of Pharmacological Sciences 121 (suppl) 247-247, 2013.

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P3-142 Immunohistochemical detection of advanced glycation end-products in rat islets of Langerhans

Yuta Morioka1), Kaori Ando2), Yasuko Tomono2), Hidenori Wake1), Kiyoshi Teshigawara1), Keyue Liu1), Masahiro Nishibori1)
1)Dept. Pharmacol., Okayama Univ. Sch. Med., 2)Shigei Res. Med.
Journal of Pharmacological Sciences 121 (suppl) 247-247, 2013.

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P3-143 Pathogenic Importance of Thromboxane A2 in Ischemia/Reperfusion (I/R)-Induced Gastric Injury in Mice

Kikuko Amagase, Toshiko Murakami, Tomoko Wada, Hikaru Kawakami, Tohru Kotani, Shinichi Kato, Koji Takeuchi
Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 247-247, 2013.

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P3-144 Potentiation by Co-Administration of Antiplatelet drugs of Aspirin-Induced Gastric Bleeding and Ulcerogenic Responses in Rats

Taiki Kawabata, Shinichi Takayama, Yuji Yoshida, Yasunari Takatsuki, Kikuko Amagase, Shinichi Kato, Koji Takeuchi
Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 247-247, 2013.

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P3-145 Biphasic Effect of Horseradish and Mustard on Gastric Ulcerogenic Responses, Dependeing on Lesion Models, in Rats

Koji Matsumoto, Toshiko Murakami, Anri Nishimura, Shunsuke Takemoto, Kikuko Amagase, Shinichi Kato, Koji Takeuchi
Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 121 (suppl) 248-248, 2013.

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P3-146 An Animal Model for Measurements of Gastro-intestinal Peristaltic Movements and Effects of Various Drugs in Conscious, un-restricted Dogs for 24 hours

Atsuko Katoh, Kazuaki Sasaki, Seiichi Katayama, Masakazu Imaizumi, Hiroshi Atai, Katsuhide Nishi
Dept. Pharmacol., Mitsubishi Chemical Medience Corporation
Journal of Pharmacological Sciences 121 (suppl) 248-248, 2013.

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P3-147 Inhibition of osteoclastogenesis by quercetin via membrane-type estrogen receptor GPR30

Masaaki Masuhara, Tomoaki Sato
Dept. Appl. Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ.
Journal of Pharmacological Sciences 121 (suppl) 248-248, 2013.

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P3-148 Suppressive effect of Rosmarinic acid and Arbutin on osteoclast differentiation in RAW264.7 cells

Akina Omori, Yoshitaka Yoshimura, Yoshiaki Deyama, Kuniaki Suzuki
Dept. Molecul. Cell Phamacol., Grad. Sch. of Den. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 248-248, 2013.

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P3-149 Lactoferrin enhances mineralization on osteoblast like MC3T3-E1 cell

Yukiko Ishibashi1), Sachiko Kikuchi2), Mayumi Nohara3), Shinji Kagaya3), Tatsuo Hoshino3), Hidefumi Kuwata3), Nobuo Izumo2)
1)Dept. Syn. Org. Chem., Yokohama Col. Pharm., 2)Dept. Clin. Pharmacol., Yokohama Col. Pharm., 3)NRL Pharma, Inc.
Journal of Pharmacological Sciences 121 (suppl) 249-249, 2013.

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P3-150 Decreased in electrical impedance of osteoclast differentiation by (-)-epigallocatechin-3-gallate

Haruka Emori1), Shinichi Iwai2), Hitoshi Amano3), Yoshiomi Oka4), Yuko Irie4), Kakei Ryu1), Katsunori Inagaki4), Shoji Yamada3), Katsuji Oguchi1)
1)Dept. Pharmacol., Sch. Med. Showa Univ., 2)Dept. Health. and Reg. Sci. Sch. Pharm. Showa. Univ., 3)Dept. Pharmacol., Sch. Dent. Showa Univ., 4)Dept. Ortho Surg., Sch. Med. Showa Univ.
Journal of Pharmacological Sciences 121 (suppl) 249-249, 2013.

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P3-151 Cafestol prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation

Yutaka Fukuma1), Eiko Sakai1), Megumi Sugawara1),2), Erika Yoneshima1),2), Kazuhisa Nishishita1), Kuniaki Okamoto1), Takayuki Tsukuba1)
1)Div. Oral Pathopharmacol, Dept. Develop. Reconstruct. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2)Div. Orthodontics and Biomedical Engineering, Dept. Develop. Reconstruct. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 121 (suppl) 249-249, 2013.

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P3-152 Effects of phenytoin on TRPV1 channels in gingival fibroblasts

Toshimi Hattori1), Toshiyuki Kawakami2)
1)Dept. Dent. Pharmacol., Matsumoto Dent. Univ., 2)Hard Tissue Pathol. Unit, Inst. Oral Sci. Matsumoto Dent. Univ.
Journal of Pharmacological Sciences 121 (suppl) 249-249, 2013.

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P3-153 Effects of reduced form-coenzyme Q10 treatment on bone metabolism in rat

Junkichi Kanda1), Nobuo Izumo2), Yoshiko Kobayashi3), Taketoshi Shimakura4), Noriaki Yamamoto4), Kenta Imai1), Kenji Onodera5), Hiroyuki Wakabayashi1)
1)Dept. Clin. Pharmacother., Niigata Univ. Pharm. Appli. Life. Sci., 2)Dept. Clin. Pharmacol., Yokohama Col. Pharm., 3)Dept. Rad. Sci., Yokohama Col. Pharm., 4)Niigata Bone Sci. Inst., 5)Lab. Pharmacother. Yokohama Col. Pharm.
Journal of Pharmacological Sciences 121 (suppl) 250-250, 2013.

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P3-154 Effect of estrogen on Na,K-ATPase activity mediated by GPR30 in macrophage

Yoshiaki Deyama1), Kota Hirasawa2), Yoshitaka Yoshimura1), Kuniaki Suzuki1)
1)Dept. of Mol. Cell. Pharmacol., Grad. Sch. of Dent. Med., Hokkaido Univ., 2)Dept. Gerodonntol., Grad. Sch. of Dent. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 121 (suppl) 250-250, 2013.

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P3-155 D-methionine as a protector for irradiation-induced oral mucositis or salivary glands dysfunction

Masanobu Yoshikawa1), Chieko Murayama1), Ana Cotrim2), Ryo-ichi Hirayama3), Yoshiya Furusawa3), Baum Bruce2)
1)Dept. Clinical Pharmacol., Tokai Univ. Sch. Med., 2)NIH/NIDCR, 3)Heavy Ion Rad. Res., NIRS
Journal of Pharmacological Sciences 121 (suppl) 250-250, 2013.

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