DRUG METABOLISM AND PHARMACOKINETICS 17巻 3号

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Genetic Polymorphism of Human Cytochrome P450 Involved in Drug Metabolism

Kiyoshi NAGATA, Yasushi YAMAZOE
Department of Drug Metabolism and Molecular Toxicology. Graduate School of Pharmaceutical Sciences. Tohoku University, Sendai. Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 167-189, 2002.

Simultaneous Assessment of the In Vivo Amount of CYPIA2 and CYP3A2 by the PKCYP-test Using Theophylline in Rats

Noriko MATSUNAGA1, Miyoko HAYASH11, Keiko YAMAMOTO1, Taeko NISHIJIMA 5, Junko KIZU2, Kazuyo NISHIHARA3, Akira TAKANAKA4, Akinobu MORIKAWA5, Emi NAKASHIMA1
1Department of Pharmaceutics, 2Practical Pharmacy. Kyoritsu College of Pharmacy. Minato-ku, Tokyo. Japan., 3 Tokyo Hospita/ of Health Insurance Association of Nippon Express. Bunnkyo-ku, Tokyo. Japan., The Organization for Pharmaceutical Safety and Research. Chiyoda-ku. Tokyo. Japan, 5Cancer Institute Hospital, Toshima-ku. Tokyo. Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 190-198, 2002.

Metabolism of Selegiline Hydrochloride, a Selective Monoamine B-type Inhibitor, in Human Liver Microsomes

Takahiro KAMADA1, 2, Toshio CHOW2, Toyoko HIR0I2, Susumu IMAOKA2, Kazuhiko MORIMOTO1, Hironori OHDE1, Yoshihiko FUNAE2
1Institute of Research and Development. Fujimoto Pharmaceutical Corporation, Nishiotsuka. Matsubara-shi. Osaka, Japan, 2Department of Chemical Biology. Osaka City University Medical School A beno ku Osaka Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 199-206, 2002.

A Mutation in the Flavin-containing Monooxygenase 3 Gene and its Effects on Catalytic A ctivity for N-oxidation of Trimethylamine In Vitro

Megumi KUBOTA1, Yoko NAKAMOTO1, Kazuo NAKAYAMA1, Pailin UJJIN2, Soisungwan SATARUG3, Taisei MUSHIRODA1, Tsuyoshi YOKOI1, Masato FUNAYAMA4, Tetsuya KAMATAKI1
1Laboratory of Drug Metabolism. Division of Pharmacobio-dynamics. Graduate School of Pharmaceutical Sciences. Hokkaido University. Sapporo. Japan, 2Department of Laboratory Medicine. Facu!ty of Medicine. Chulalongkorn University, Bangkok. Thailand., 3National Research Center for Environmental Toxicology. University of Queensland. Brisbane. A ustralia., 4Department of Legal Medicine. Sapporo Medical University. Sapporo. Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 207-213, 2002.

Studies on the Metabolic Fate of M17055, a Novel Diuretic

Hiroyuki NAKAJIMA, Hiroyasu NABA, Takeshi NAKANISHI, Kiyohiko NAKAI, Takanori WATANABE, Keiichi IDA, Nobuo OHZAWA
Drug Metabolism and Pharmacokinetics Laboratory, Research Center, Mochida Pharmaceutical Co. . Ltd. . Gotemba Shizuoka, Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 214-220, 2002.

Sulfation of Environmental Estrogens by Cytosolic Human Sulfotransferases

Takahito NISHIYAMA1, Kenichiro OGURA1, Hiroaki NAKAN02, Teppei KAKU1, Eriko TAKAHASHI1, Yasunari OHKUBO1, Koji SEKINE1, Akira HIRATSUKA1, Shigetoshi KADOTA3, Tadashi WATABE1, 3
1Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy, Tokyo University of Pharmacy and Life Science. Hachioji-shi. Tokyo. Japan, 2Corporate. Scientlfic and Regulatory Affairs Division. Tobacco Headquarters. Japan Tobacco Inc. . Minato-ku, Tokyo. Japan, 3lnstitute of Natura/ Medicine. Toyama Medical and Pharmaceutical University. Sugitani. Toyama. Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 221-228, 2002.

Identification of Inhibitory Component in Cinnamon O-Methoxycinnamaldehyde Inhibits CYPIA2 and C YP2E1

Atsushi HASEGAWA1, Masaki YOSHIN02, Hiroyoshi NAKAMURA1, Itsuko ISHII2, Toshiko WATANABE2, Masahiro KIUCHI3, Tsutomu ISHIKAWA2, Shigeru OHMORl4, Mitsukazu KITADA1
1Division of Pharmacy, Chiba University Hospital. Faculty of Medicine. Chiba University, Chiba, Japan, 2Facult o Pharmaceutical Sciences. Chiba University. Chiba Japan, 3De artment o Legal Medicine Chiba University School of Medicine. Chiba Japan, 4Division of Pharmacy. Shinshu University Hospita/. Shinshu University School of Medicine. Matsumoto, Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 229-236, 2002.

Muscle Distribution of Antimicrobial Agents after a Single Intravenous Administration to Rats

Harumi ARAKI1, Naoko OGAKE1, Reiko TSUNEDA1, Shinzaburo MINAMI1, Yasuo WATANABE1, Ikumi TAMAI2, Akira TSUJI3
1Research Laboratories, Toyama Chemical Co. . Ltd. . Shimookui. Toyama. Japan, 2Department of Pharmaceutics, Faculty of Pharmaceutica/ Sciences. Science University of Tokyo. Tokyo, Japan, 3Department of Pharmaceutics. Faculty of Pharmaceutica/ Sciences. Kanazawa University. Kanazawa. Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 237-244, 2002.

Interaction of Endogenous Compounds in Human and Rat Urine with P-glycoprotein

Teruo MURAKAMI, Takeshi FUKUDA, Ryoko YUMOTO, Junya NAGAI, Taiju KURAMOTO, Mikihisa TAKANO
Department of Pharmaceutics and Therapeutics. Division of Clinical Pharmaceutical Science, Programs for Pharmaceutical Sciences. Graduate School of Biomedical Sciences, Hiroshima University. Hiroshima. Japan
DRUG METABOLISM AND PHARMACOKINETICS 17 (3) 245-252, 2002.

DRUG METABOLISM AND PHARMACOKINETICS 17巻 3号

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