バックナンバー:DRUG METABOLISM AND PHARMACOKINETICS

DRUG METABOLISM AND PHARMACOKINETICS
17巻 6号

  • CYPalleles: A Web Page for Nomenclature of Human Cytochrome P450 Alleles

    Mikael OSCARSON1, Magnus INGELMAN-SUNDBERG2
    1Division of Pharmacology/Neurobiology, Biozentrum, Universlty of Basel Basel Swltzerland, 2Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet. Stockholm, Sweden
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 491-495, 2002.


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  • Kinetic Impact of Presystemic Intestinal Metabolism on Drug Absorption: Experiment and Data Analysis for the Prediction of In Vivo Absorption from In Vitro Data

    Takashi MIZUMA
    Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 496-506, 2002.


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  • Species Differences in the Metabolism of (+)- and (-)-Limonenes and their Metabolites, Carveols and Carvones, by Cytochrome P450 Enzymes in Liver Microsomes of Mice. Rats. Guinea Pigs. Rabbits. Dogs, Monkeys, and Humans

    Tsutomu SHIMADA1, Masaki SHIND02, Mitsuo MIYAZAWA
    1Osaka Prefectural Institute of Public Health, 2Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 507-515, 2002.


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  • Major Cytochrome P450 Enzymes Responsible for Microsomal Aldehyde Oxygenation of 11-Oxo-Δ8-tetrahydrocannabinol and 9-Anthraldehyde in Human Liver

    Kazuhito WATANABE1, Tamihide MATSUNAGA1, 2, Toshiyuki KIMURA1, Tatsuya FUNAHASHI1, Yoshihiko FUNAE3, Tohru OHSHIMA4, Ikuo YAMAMOTO5
    1Faculty of Pharmaceutical Sciences, Hokuriku University, 2Division of Pharmacy, Shinshu University Hospital, 3Osaka City University School of Medicine, 4Kanazawa University Faculty of Medicine, School of Medicine, Kanazawa, 5Kyushu University of Health and Welfare
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 516-521, 2002.


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  • Effects of Serum Albumin and Liver Cytosol on CYP2C9 and C YP3A4-mediated Drug Metabolism

    Takahiko BABA1, Akira TOUCHI1, Kiyomi ITO2, Yoshitaka YAMAGUCHI1, Yasushi YAMAZOE3, Yasuo OHNO4, Yuichi SUGIYAMA5
    1Shionogi & Co. , Ltd. , Developmental Research Laboratories, 2School of Pharmaceutical Sciences, Kitasato University, 3Division of Drug Metabolism and Molecular Toxlcology, Graduate School of Pharmaceutical Sciences, Tohoku University, 4Health Sciences, Division of Pharmacology, Biological Safety Research Center, National Institute of Health Sciences, 5Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Tokyo
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 522-531, 2002.


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  • Determination of a Novel Haplotype of P2-adrenergic Receptor in the Japanese Population by the Combination of the Electronic Microchip Assay Using the NanoChip System with Allele-specific PCR

    Nobuyo YOSHIDA1, 2, Masahide SUGIYAMA1, 3, Akito TANOUE1, Akira HIRASAWA1, Hirohisa SAITO4, Gozoh TSUJIMOTO1, 5
    1Department of Molecular, Cell Pharmacology, National Research Institute for Child Health and Development, 2Hitachi High-Technologies Corporation, 3Hitachi Instruments Service Co. , Ltd., 4Department of Allergy and Immunology, National Research Institute for Child Health and Development, 5Department of Genomic Drug Discovery Science Graduate School of Pharmaceutical Science. Kyoto University
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 532-539, 2002.


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  • Plasma Retinol Binding Protein for Monitoring the Acetaminophen-induced Hepatotoxicity

    Masanao ISOZAKI, Kousei ITO, Yasuhiro MASUBUCHI, Toshiharu HORIE
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 540-545, 2002.


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  • Metabolic Extraction of Nifedipine during Absorption from the Rat Small Intestine

    Takahiro IWAO1, Katsuhisa INOUE1, Yayoi HAYASHI1, Hiroaki YUASA1, Jun WATANABE2
    1Graduate School of Pharmaceutical Sciences, Nagoya City University, 2College of Pharmacy, Nihon University
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 546-553, 2002.


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  • Involvement of Specific Transport System of Renal Basolateral Membranes in Distribution of Nicotine in Rats

    Atsuko FUKADA, Hideyuki SAITO, Yumiko URAKAMI, Masahiro OKUDA, Ken-ichi INUI
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 554-560, 2002.


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  • Eleven Novel Single Nucleotide Polymorphisms in the NR112 (PXR) Gene. Four of which Induce Non-synonymous Amino Acid Alterations

    Satoru KOYANO1, Kouichi KUROSE1, 2, Shogo OZAWA1, 3, Mayumi SAEKI1, Yukiko NAKAJIMA1, Ryuichi HASEGAWA2, Kazuo KOMAMURA4, 6, Kazuyuki UENO5, Shiro KAMAKURA4, Toshiharu NAKAJIMA7, Hirohisa SAITO7, Hideo KIMURA8, Yu-ichi GOTO8, Osamu SAITOH9, Masaaki KATOH9, Teiichi OHNUMA9, Mitsuru KAWAI9, Kenji SUGAI9, Taisuke OHTSUKI9, Chieko SUZUKI9, Narihiro MINAMI8, 9, Yoshiro SAITO1, 10, Junichi SAWADA1, 10
    1Project team for Pharmacogenetics, 2Division of Medicinal Safety Science, 3Division of Pharmacology, 10Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, 4Division of Cardiology, 5Department of Pharmacy, 6Department of Cardiovascular Dynamics Research Institute. National Cardiovascular Center, 7Department of Allergy and Immunology, National Research Institute for Child Health and Development, National Center for Child Health and Development, 8National Institute of Neuroscience, 9National Center Hospital for Mental, Nervous and Muscular Disorders, National Center for Neurology and Psychiatry
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 561-565, 2002.


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  • Twelve Novel Single Nucleotide Polymorphisms in ABCB1/MDR1 among Japanese Patients with Ventricular Tachycardia who were Administered Amiodarone

    Masaya ITODA1, Yoshiro SAITO1, 2, Kazuo KOMAMURA3, 4, Kazuyuki UENO5, Shiro KAMAKURA3, Shogo OZAWA1, 6, Jun-ichi SAWADA1, 2
    1Project team for Pharmacogenetics, 2Division of Biochemistry and Immunochemistry, 6Division of Pharmacology, National Institute of Health Sciences, 3Department of Cardiology, 4Department of Cardiovascular Dynamics Research Institute, 5Department of Pharmacy, National Cardiovascular Center
    DRUG METABOLISM AND PHARMACOKINETICS 17(6): 566-571, 2002.


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book
発行元:
日本薬物動態学会
ISSN:
1347-4367
ISSN(オンライン):
1880-0920
前雑誌:
薬物動態

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