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Are Non-human Primates Useful Experimental Animals for Pre-clinical Study?
Masakiyo Hosokawa
DMPK Associate Editor
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 221-222, 2010.
DMPK Associate Editor
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 221-222, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
Assessment of Chimeric Mice with Humanized Liver as a Tool for Predicting Circulating Human Metabolites
Hidetaka KAMIMURA1, Naoyuki NAKADA1, Katsuhiro SUZUKI1, Ayako MERA1, Kinya SOUDA1, Yuichi MURAKAMI2, Kohichiro TANAKA3, Takafumi IWATSUBO1, Akio KAWAMURA1, Takashi USUI1
1Drug Metabolism Research Laboratories, Astellas Pharma Inc., 2Drug Safety Research Laboratories, Astellas Pharma Inc., 3Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc.
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 223-235, 2010.
1Drug Metabolism Research Laboratories, Astellas Pharma Inc., 2Drug Safety Research Laboratories, Astellas Pharma Inc., 3Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc.
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 223-235, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Secretion of Albumin and Induction of CYP1A2 and CYP3A4 in Novel Three-dimensional Culture System for Human Hepatocytes using Micro-space Plate
Masuhiro NISHIMURA1, Mieko HAGI1, Yoko EJIRI2, Sanae KISHIMOTO1, Toru HORIE3, Shizuo NARIMATSU4, Shinsaku NAITO1
1Research and Development Center, Otsuka Pharmaceutical Factory, Inc., 2Tsukuba Research Center, Kuraray Co., Ltd., 3D Three Research Laboratories, 4Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 236-242, 2010.
1Research and Development Center, Otsuka Pharmaceutical Factory, Inc., 2Tsukuba Research Center, Kuraray Co., Ltd., 3D Three Research Laboratories, 4Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 236-242, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Estimation of the Interindividual Variability of Cytochrome 2D6 Activity from Urinary Metabolic Ratios in the Literature
Takashi ITO1, Motohiro KATO2, Koji CHIBA3, Osamu OKAZAKI1, Yuichi SUGIYAMA4
1Drug Metabolism & Pharmacokinetics Research Laboratories, R & D Division, Daiichi Sankyo Co., Ltd., 2Pre-clinical Research Dept., Chugai Pharmaceutical Co., Ltd., 3Faculty of Pharmacy, Keio University, 4Graduate School of Pharmaceutical Sciences, The University of Tokyo
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 243-253, 2010.
1Drug Metabolism & Pharmacokinetics Research Laboratories, R & D Division, Daiichi Sankyo Co., Ltd., 2Pre-clinical Research Dept., Chugai Pharmaceutical Co., Ltd., 3Faculty of Pharmacy, Keio University, 4Graduate School of Pharmaceutical Sciences, The University of Tokyo
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 243-253, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Pharmacokinetic and Pharmacodynamic Analysis of Acetylcholinesterase Inhibition by Distigmine Bromide in Rats
Yoshihiko ITO1, Taketsugu HARADA1, Kasumi FUSHIMI1, Yoshiyuki KAGAWA1, Hidenobu OKA2, Hiroshi NAKAZAWA2, Reiko HOMMA2, Yoshihisa KATO3, Shizuo YAMADA1
1Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 2Research Laboratory, Torii Pharmaceutical Co., LTD, 3Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 254-261, 2010.
1Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence (COE) and Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, 2Research Laboratory, Torii Pharmaceutical Co., LTD, 3Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 254-261, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver
Arief NURROCHMAD5, Yuji ISHII1, Hitomi NAKANOH1, Tae INOUE3, Toru HORIE3, Kazumi SUGIHARA4, Shigeru OHTA4, Akinobu TAKETOMI2, Yoshihiko MAEHARA2, Hideyuki YAMADA1
1Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 2Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3PhoenixBio.Co., Ltd., 4Graduate School of Biomedical Sciences, Hiroshima University, 5Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 262-273, 2010.
1Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 2Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3PhoenixBio.Co., Ltd., 4Graduate School of Biomedical Sciences, Hiroshima University, 5Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Gadjah Mada University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 262-273, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
The HMG-CoA Reductase Inhibitor Pravastatin Stimulates Insulin Secretion through Organic Anion Transporter Polypeptides
Michiaki ABE1, Takafumi TOYOHARA1, Akiko ISHII2, Takehiro SUZUKI1, Naoya NOGUCHI3, Yasutoshi AKIYAMA1, Hiromi O.SHIWAKU1, Rie NAKAGOMI-HAGIHARA4, Guodong ZHENG1, Eisuke SHIBATA1, Tomokazu SOUMA1, Tomohiko SHINDO1, Hirohito SHIMA1, Yoichi TAKEUCHI1, Eikan MISHIMA1, Masayuki TANEMOTO1, Tetsuya TERASAKI5, Tohru ONOGAWA6, Michiaki UNNO6, Sadayoshi ITO1, Shin TAKASAWA7, Takaaki ABE1, 8, 9
1Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, 2Diabetes Center, Tokyo Women's Medical University School of Medicine, 3Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine, 4Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi-Sankyo Co., Ltd., 5Graduate School of Pharmaceutical Sciences, Tohoku University, 6Department of Surgery, Tohoku University Graduate School of Medicine, 7Department of Biochemistry, Nara Medical University, 8Division of Medical Science, Tohoku University Graduate School of Biomedical Engineering, 9Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 274-282, 2010.
1Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, 2Diabetes Center, Tokyo Women's Medical University School of Medicine, 3Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine, 4Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi-Sankyo Co., Ltd., 5Graduate School of Pharmaceutical Sciences, Tohoku University, 6Department of Surgery, Tohoku University Graduate School of Medicine, 7Department of Biochemistry, Nara Medical University, 8Division of Medical Science, Tohoku University Graduate School of Biomedical Engineering, 9Department of Clinical Biology and Hormonal Regulation, Tohoku University Graduate School of Medicine
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 274-282, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Stereoselective Transport of Amethopterin Enantiomers by the Proton-coupled Folate Transporter
Tomoya NARAWA, Tomoo ITOH
School of Pharmacy, Kitasato University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 283-289, 2010.
School of Pharmacy, Kitasato University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 283-289, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Regional Distribution of Cytochrome P450 mRNA Expression in the Liver and Small Intestine of Cynomolgus Monkeys
Yasuharu NAKANISHI1, Akinori MATSUSHITA1, Kiyomi MATSUNO1, Kazuhide IWASAKI2, Masahiro UTOH1, Chika NAKAMURA1, Yasuhiro UNO1
1Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., 2Business Development Division, Shin Nippon Biomedical Laboratories, Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 290-297, 2010.
1Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., 2Business Development Division, Shin Nippon Biomedical Laboratories, Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 290-297, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Enhanced Susceptibility of HLA-mediated Ticlopidine-induced Idiosyncratic Hepatotoxicity by CYP2B6 Polymorphism in Japanese
Noritaka ARIYOSHI1, 4, Yukako IGA2, Koji HIRATA3, Yasunori SATO4, 5, Go MIURA1, Itsuko ISHII2, Seiji NAGAMORI6, Mitsukazu KITADA1
1Division of Pharmacy, University Hospital, Chiba University School of Medicine, 2Graduate School of Medical and Pharmaceutical Sciences, Chiba University, 3Product Lifecycle Management Department, Daiichi, 4Clinical Research Center, Chiba University Hospital, 5Department of Biostatistics, Harverd School of Public Health, 6Department of Pharmacology and Toxicology, Kyorin University School of Medicine
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 298-306, 2010.
1Division of Pharmacy, University Hospital, Chiba University School of Medicine, 2Graduate School of Medical and Pharmaceutical Sciences, Chiba University, 3Product Lifecycle Management Department, Daiichi, 4Clinical Research Center, Chiba University Hospital, 5Department of Biostatistics, Harverd School of Public Health, 6Department of Pharmacology and Toxicology, Kyorin University School of Medicine
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 298-306, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
The Influence of Aged Garlic Extract on the Uptake of Saquinavir and Darunavir into HepG2 Cells and Rat Liver Slices
Katja BERGINC, Jurij TRONTELJ, Albin KRISTL
Faculty of pharmacy, University of Ljubljana
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 307-313, 2010.
Faculty of pharmacy, University of Ljubljana
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 307-313, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Transport of Estrone 3-sulfate Mediated by Organic Anion Transporter OATP4C1: Estrone 3-sulfate binds to the Different Recognition Site for Digoxin in OATP4C1
Hiroaki YAMAGUCHI5, Misa SUGIE2, Masahiro OKADA2, Tsuyoshi MIKKAICHI2, Takafumi TOYOHARA3, Takaaki ABE3, Junichi GOTO1, Takanori HISHINUMA4, Miki SHIMADA1, 2, Nariyasu MANO1, 2
1Department of Pharmaceutical Sciences, Tohoku University Hospital, 2Division of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku University, 3Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Biomedical Engineering, 4Division of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, 5Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 314-317, 2010.
1Department of Pharmaceutical Sciences, Tohoku University Hospital, 2Division of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku University, 3Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Biomedical Engineering, 4Division of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University, 5Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
DRUG METABOLISM AND PHARMACOKINETICS 25 (3) 314-317, 2010.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
