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In vitro and in vivo Characterization of New Formulations of St. John's Wort Extract with Improved Pharmacokinetics and Anti-nociceptive Effect
Junya HATANAKA1,2, Yukiko SHINME1, Kazuki KURIYAMA1, Atsushi UCHIDA1, Keitatsu KOU3, Shinya UCHIDA1, Shizuo YAMADA1, Satomi ONOUE1
1Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka, 2Functional Foods Laboratory, Yokohama Oils and Fats Industry Co., Ltd., 3Laboratory of Electron Microscopy, Showa University School of Medicine
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 551-558, 2011.
1Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE) Program, School of Pharmaceutical Sciences, University of Shizuoka, 2Functional Foods Laboratory, Yokohama Oils and Fats Industry Co., Ltd., 3Laboratory of Electron Microscopy, Showa University School of Medicine
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 551-558, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Inhibition of Cytochrome P450 2C8-mediated Drug Metabolism by the Flavonoid Diosmetin
Luigi QUINTIERI1, Pietro PALATINI1, Stefano MORO2, Maura FLOREANI1
1Department of Pharmacology and Anaesthesiology, University of Padova, 2Molecular Modeling Section (MMS), Department of Pharmaceutical Sciences, University of Padova
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 559-568, 2011.
1Department of Pharmacology and Anaesthesiology, University of Padova, 2Molecular Modeling Section (MMS), Department of Pharmaceutical Sciences, University of Padova
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 559-568, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Metabolomic Analysis Reveals Novel Isoniazid Metabolites and Hydrazones in Human Urine
Feng LI1, Yan MIAO2, Lirong ZHANG3, Sarah Ann NEUENSWANDER4, Justin T.DOUGLAS4, Xiaochao MA1
1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 2Department of Rheumatism and Nephrology, People's Hospital of Henan Province, 3Department of Pharmacology, School of Medicine, Zhengzhou University, 4Nuclear Magnetic Resonance Laboratory, University of Kansas
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 569-576, 2011.
1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 2Department of Rheumatism and Nephrology, People's Hospital of Henan Province, 3Department of Pharmacology, School of Medicine, Zhengzhou University, 4Nuclear Magnetic Resonance Laboratory, University of Kansas
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 569-576, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Induction of CYP1 Family Members under Low-glucose Conditions Requires AhR Expression and Occurs through the Nuclear Translocation of AhR
Jun TERASHIMA, Wataru HABANO, Toshie GAMOU, Shogo OZAWA
Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 577-583, 2011.
Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 577-583, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Decreased Expression of Intestinal P-glycoprotein Increases the Analgesic Effects of Oral Morphine in a Streptozotocin-induced Diabetic Mouse Model
Ayaka NAWA1, Wakako FUJITA-HAMABE1, Shiroh KISHIOKA2, Shogo TOKUYAMA1
1Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, 2Department of Pharmacology, Wakayama Medical University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 584-591, 2011.
1Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, 2Department of Pharmacology, Wakayama Medical University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 584-591, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Prediction of the Intestinal First-pass Metabolism of CYP3A and UGT Substrates in Humans from in vitro Data
Haruka NISHIMUTA, Kimihiko SATO, Masashi YABUKI, Setsuko KOMURO
Pharmacokinetics Research Laboratory, Dainippon Sumitomo Pharma Co.,Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 592-601, 2011.
Pharmacokinetics Research Laboratory, Dainippon Sumitomo Pharma Co.,Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 592-601, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Molecular-weight-dependent, Anionic-substrate-preferential Transport of β-Lactam Antibiotics via Multidrug Resistance-associated Protein 4
Shin-ichi AKANUMA1,2, Yasuo UCHIDA1, Sumio OHTSUKI1,3, Jun-ichi KAMIIE1,3,4, Masanori TACHIKAWA2, Tetsuya TERASAKI1,3, Ken-ichi HOSOYA2
1Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 2Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 3SORST, Japan Science and Technology Agency (JST), 4Graduate School of Veterinary Science, Azabu University.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 602-611, 2011.
1Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, 2Department of Pharmaceutics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 3SORST, Japan Science and Technology Agency (JST), 4Graduate School of Veterinary Science, Azabu University.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 602-611, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Bridging from Preclinical to Clinical Studies for Tyrosine Kinase Inhibitors Based on Pharmacokinetics/Pharmacodynamics and Toxicokinetics/Toxicodynamics
Azusa HOSHINO-YOSHINO1,2, Motohiro KATO2, Kohnosuke NAKANO2, Masaki ISHIGAI2, Toshiyuki KUDO1, Kiyomi ITO1
1Research Institute of Pharmaceutical Sciences, Musashino University, 2Pre-clinical Research Department, Chugai Pharmaceutical Co. Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 612-620, 2011.
1Research Institute of Pharmaceutical Sciences, Musashino University, 2Pre-clinical Research Department, Chugai Pharmaceutical Co. Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 612-620, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Expression of Cytochromes P450 in Fetal, Infant, and Juvenile Liver of Cynomolgus Macaques
Ryota ISE1, Satoshi KONDO2, Hiroto KATO1, Noritaka IMAI1, Hideo AKIYAMA2, Kazuhide IWASAKI3, Hiroshi YAMAZAKI4, Yasuhiro UNO5
1Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2Toray Industries, Inc., 3Business Development Division, Shin Nippon Biomedical Laboratories, Ltd., 4Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 5Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 621-626, 2011.
1Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., 2Toray Industries, Inc., 3Business Development Division, Shin Nippon Biomedical Laboratories, Ltd., 4Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, 5Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 621-626, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Discovery of Genetic Variants in CYP1D1:Implication for Functional Integrity of CYP1D1 in Cynomolgus Macaques and Rhesus Macaques
Yasuhiro UNO1, Shotaro UEHARA1, Hiroshi YAMAZAKI2
1Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., 2Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 627-631, 2011.
1Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., 2Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 627-631, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Carnitine Precursor γ-Butyrobetaine is a Novel Substrate of the Na+- and Cl- -dependent GABA Transporter Gat2
Takeo NAKANISHI, Yoko FUKUYAMA, Masaharu FUJITA, Yoshiyuki SHIRASAKA, Ikumi TAMAI
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 632-636, 2011.
Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 632-636, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Single Nucleotide Polymorphisms in the Human Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Gene
Jonathan D.URBAN1, Robert A.BUDINSKY2, J.Craig ROWLANDS2
1ToxStrategies, 2The Dow Chemical Company, Toxicology and Environmental Research and Consulting
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 637-645, 2011.
1ToxStrategies, 2The Dow Chemical Company, Toxicology and Environmental Research and Consulting
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 637-645, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Genetic Variation and Haplotype Structures of the Glutathione S-transferase Genes GSTA1 and GSTA2 in Japanese Colorectal Cancer Patients
Keiko MAEKAWA1,2, Tetsuya HAMAGUCHI3, Yoshiro SAITO1,2, Naoko TATEWAKI2, Kouichi KUROSE1,2, Nahoko KANIWA1,2, Takako EGUCHI NAKAJIMA*, Ken KATO3, Yasuhide YAMADA3, Yasuhiro SHIMADA3, Teruhiko YOSHIDA4, Naoyuki KAMATANI5, Takashi URA6, Miyuki SAITO6, Kei MURO6, Nozomu FUSE7, Takayuki YOSHINO7, Toshihiko DOI7, Atsushi OTSU7,8, Nagahiro SAIJO**, Jun-ichi SAWADA***, Haruhiro OKUDA2,10, Yasuhiro MATSUMURA11
1Division of Medicinal Safety Science, National Institute of Health Sciences, 2Project Team for Pharmacogenetics, National Institute of Health Sciences, 3Gastrointestinal Oncology Division, National Cancer Center Hospital, National Cancer Center, 4Genetics Division, National Cancer Center Research Institute, National Cancer Center, 5Statistical Analysis Team, Center for Genomic Medicine (CGM), RIKEN, 6Department of Medical Oncology, Aichi Cancer Center Hospital, 7Division of Gastrointestinal Oncology/Digestive Endoscopy, National Cancer Center Hospital East, 8Research Center for Innovative Oncology, National Cancer Center Hospital East, 9National Cancer Center Hospital East, 10Division of Organic Chemistry, National Institute of Health Sciences, 11Investigative Treatment Division, National Cancer Center Hospital East, *Department of Clinical Oncology, St.Marianna University School of Medicine, **Kinki University School of Medicine, ***Pharmaceuticals and Medical Devices Agency
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 646-658, 2011.
1Division of Medicinal Safety Science, National Institute of Health Sciences, 2Project Team for Pharmacogenetics, National Institute of Health Sciences, 3Gastrointestinal Oncology Division, National Cancer Center Hospital, National Cancer Center, 4Genetics Division, National Cancer Center Research Institute, National Cancer Center, 5Statistical Analysis Team, Center for Genomic Medicine (CGM), RIKEN, 6Department of Medical Oncology, Aichi Cancer Center Hospital, 7Division of Gastrointestinal Oncology/Digestive Endoscopy, National Cancer Center Hospital East, 8Research Center for Innovative Oncology, National Cancer Center Hospital East, 9National Cancer Center Hospital East, 10Division of Organic Chemistry, National Institute of Health Sciences, 11Investigative Treatment Division, National Cancer Center Hospital East, *Department of Clinical Oncology, St.Marianna University School of Medicine, **Kinki University School of Medicine, ***Pharmaceuticals and Medical Devices Agency
DRUG METABOLISM AND PHARMACOKINETICS 26 (6) 646-658, 2011.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
