バックナンバー:Biological and Pharmaceutical Bulletin

Biological and Pharmaceutical Bulletin
30巻 1号

  • Pharmacokintics of the Ginkgo Bfollowing Intravenous Administration of Ginkgo B Emulsion in Rats

    Wei-Dong CHEN*a*b, Yan LIANG*a, Lin XIE*a, Tong LU*a, Xiao-Dong LIU*a, Guang-Ji WANG*a
    *aKey Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University, *bThe Hospital of the 17th Metallurgical Construction Company
    Biological & Pharmaceutical Bulletin 30(1): 1-5, 2007.


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  • Effect of Magnesium Deficiency on Intracellular ATP Levels in Human Lens Epithelial Cells

    Noriaki NAGAI, Takashi FUKUHATA, Yoshimasa ITO
    Kinki University School of Pharmacy
    Biological & Pharmaceutical Bulletin 30(1): 6-10, 2007.


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  • Cloning, Expression and Purification of Arylsulfate Sulfotransferase from Eubacterium A-44

    Bomi KIM*a, Yang-Jin HYUN*a, Keun-Sook LEE*a, Kyoichi KOBASHI*b, Dong-Hyun KIM*a
    *aCollege of Pharmacy, Kyung Hee University, *bToyama New Industry Organization
    Biological & Pharmaceutical Bulletin 30(1): 11-14, 2007.


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  • Nitration of Specific Tyrosine Residues of Cytochrome c Is Associated with Caspase-Cascade Inactivation

    Hidehiko NAKAGAWA*a, Nobuko KOMAI*b, Mitsuko TAKUSAGAWA*b, Yuri MIURA*c, Tosifusa TODA*c, Naoki MIYATA*a, Toshihiko OZAWA*b, Nobuo IKOTA*b
    *aDepartment of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, *bRedox Regulation Research Group, National Institute of Radiological Sciences, *cTokyo Metropolitan Institute of Gerontology
    Biological & Pharmaceutical Bulletin 30(1): 15-20, 2007.


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  • The Additive Effects of Minoxidil and Retinol on Human Hair Growth in Vitro

    Hyeon Gyeong Yoo, In-Young CHANG, Hyun Keol PYO, Yong Jung KANG, Seung Ho LEE, Oh Sang KWON, Kwang Hyun CHO, Hee Chul EUN, Kyu Han KIM
    Department of Dermatology, Seoul National University College of Medicine, Laboratory of Cutaneous Aging and Hair Research, Clinical Research Institute, Seoul National University Hospital, Institute of Dermatological Science, Seoul National University
    Biological & Pharmaceutical Bulletin 30(1): 21-26, 2007.


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  • Stimulatory Effects of Hydroxyl Radical Generation by Ga-Al-As Laser Irradiation on Mineralization Ability of Human Dental Pulp Cells

    Satoshi MATSUI, Yasuhisa TSUJIMOTO, Kiyoshi MATSUSHIMA
    Department of Endodontics, Nihon University School of Dentistry at Matsudo
    Biological & Pharmaceutical Bulletin 30(1): 27-31, 2007.


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  • The Anti-apoptotic and Anti-oxidant Effect of Eriodictyol on UV-Induced Apoptosis in Keratinocytes

    Eung-Ryoung LEE, Jung-Hyun KIM, Yong-Jin KANG, Ssang-Goo CHO
    Department of Animal Biotechnology and Bio/Molecular Informatics Center, Konkuk University
    Biological & Pharmaceutical Bulletin 30(1): 32-37, 2007.


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  • Effects of Anemarrhena asphodeloides on Focal Ischemic Brain Injury Induced by Middle Cerebral Artery Occlusion in Rats

    Jin Kyung OH*a, Seung Ye HYUN*a, Hye Rim OH*a, Ji Wook JUNG*a, Chan PARK*b, Sun-Young LEE*c, Ji Ho PARK*c, Sun Yeou KIM*c, Ki Hoon KIM*d, Young Kyun KIM*d, Jong Hoon RYU*a
    *aDepartment of Oriental Pharmaceutical Science. College of Pharmac, Kyung Hee University, *bDepartment of Anatomy, College of Medicine, Kyung Hee University, *cGraduate School of East-West Medical Science, Kyung Hee University, *dDepartment of Forest Products, College of Forest Science, Kookmin University
    Biological & Pharmaceutical Bulletin 30(1): 38-43, 2007.


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  • Protective Effect of Salvianic Acid A on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

    Chao-Yun WANG*a*b, Fu-Lu MA*b, Jun-Tian LIU*a, Jing-Wei TIAN*b, Feng-Hua FU*b
    *aDepartment of Pharmacology, Xi'an Jiaotong University School of Medicine, *bShandong Engineering Research Center for Nature Drug
    Biological & Pharmaceutical Bulletin 30(1): 44-47, 2007.


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  • Endothelium-Dependent Vasodilatory and Hypotensive Effects of Crotalaria Sessiliflora L. in Rats

    Sang Bum KOH*a*b, Myung Hwa KANG*c, Tae Su KIM*c, Hee Woon PARK*d, Chun Geon PARK*d, Yeon Hee SEONG*b, Ha Jung SEONG*a
    *aSafety Assessment Center, Korea Testing and Research Institute for Chemical Industry, *bCollege of Veterinary Medicine and Research Institute of Herbal Medicine, Chungbuk National University, *cDepartment of Food Science and Nutrition, Hoseo University, *dNational Institute of Crop Science, RDA
    Biological & Pharmaceutical Bulletin 30(1): 48-53, 2007.


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  • Pharmacological Characterization of a New Antimuscarinic Agent, Solifenacin Succinate, in Comparison with Other Antimuscarinic Agents

    Akiyoshi OHTAKE, Chikashi SAITOH, Hironori YUYAMA, Masashi UKAI, Hiroko OKUTSU, Yukiko NOGUCHI, Toshiki HATANAKA, Masanori SUZUKI, Shuichi SATO, Masao SASAMATA, Keiji MIYATA
    Pharmacology Research Labs., Drug Discovery Research, Astellas Pharma Inc.
    Biological & Pharmaceutical Bulletin 30(1): 54-58, 2007.


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  • Tetrandrine Inhibits Proinflammatory Cytokines, iNOS and COX-2 Expression in Human Monocytic Cells

    Shu-Jing WU*a, Lean-Teik NG*b
    *aDepartment of Health and Nutrition, Chia-Nan University of Pharmacy and Technology, *bDepartment of Biotechnology, Tajen University
    Biological & Pharmaceutical Bulletin 30(1): 59-62, 2007.


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  • Anti-inflammatory Activity of Bis(3-aryl-3-oxo-propyl)methylamine Hydrochloride in Rat

    Halis SULEYMAN*a, Halise Inci GUL*b, Mustafa GUL*c, Mustafa ALKAN*a, Fatma GOCER*a
    *aDepartment of Pharmacology, Faculty of Medicine, Ataturk University, *bDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, *cDepartment of Physiology, Faculty of Medicine, Ataturk University
    Biological & Pharmaceutical Bulletin 30(1): 63-67, 2007.


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  • Fcr1p Inhibits Development of Fluconazole Resistance in Candida albicans by Abolishing CDR1 Induction

    Hui SHEN*a, Mao-Mao AN*b, De Jun WANG*a, Zheng XU*a, Jun-Dong ZHANG*a, Ping-Hui GAO*a, Ying-Ying CAO*a, Yong-Bing CAO*a, Yuan-Ying JIANG*a
    *aDepartment of Pharmacology, School of Pharmacy, Second Military Medical University, *bDepartment of Clinical Pharmacology, Chinese People's Liberation Army General Hospital
    Biological & Pharmaceutical Bulletin 30(1): 68-73, 2007.


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  • Comparative Antioxidant Activities of Curcumin and Its Demethoxy and Hydrogenated Derivatives

    Poorichaya SOMPARN*a, Chada PHISALAPHONG*b, Somjai NAKORNCHAI*a, Supeenun UNCHERN*c, Noppawan Phumala MORALES*c
    *aDepartment of Pharmacology, Faculty of Pharmacy, Mahidol University, *bGovernment Pharmaceutical Organization, *cDepartment of Pharmacology, Faculty of Science, Mahidol University
    Biological & Pharmaceutical Bulletin 30(1): 74-78, 2007.


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  • Gentamicin-Induced Nephrotoxicity in Rats Ameliorated and Healing Effects of Resveratrol

    Coskun SILAN*a, Ozge UZUN*a, Nil Ustundag COMUNOGLU*b, Sanem GOKCEN*c, Selma BEDIRHAN*a, Mujgan CENGIZ*c
    *aDepartment of Pharmacology, Faculty of Medicine, Duzce University, *bYeditepe University, School of Medicine Department of Pathology, *cUniversity of Istanbul, Cerrahpasa School of Medicine, Department of Medical Biology
    Biological & Pharmaceutical Bulletin 30(1): 79-83, 2007.


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  • Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat

    Chhanda MALLICK*a*c, Suvra MANDAL*b, Bikashranjan BARIK*b, Atanu BHATTACHARYA*b, Debidas GHOSH*c
    *aReproductive Endocrinology and Family Welfare Research Unit, Department of Human Physiology with Community Health, Vidyasagar University, *bDepartment of Chemistry, Central Research Institute, *cDepartment of Bio-Medical Laboratory Science and Management, Vidyasagar University
    Biological & Pharmaceutical Bulletin 30(1): 84-90, 2007.


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  • A Novel Vasopressin Dual V1A/V2 Receptor Antagonist, Conivaptan Hydrochloride, Improves Hyponatremia in Rats with Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

    Koh-ichi WADA*a, Utane MATSUKAWA*b, Akira FUJIMORI*a, Yukinori ARAI*a, Katsumi SUDOH*a, Masao SASAMATA*a, Keiji MIYATA*a
    *aPharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., *bClinical Development Administration, Development, Astellas Pharma Inc.
    Biological & Pharmaceutical Bulletin 30(1): 91-95, 2007.


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  • Cardiovascular Effects of an n-Butanol Extract from Fresh Fruits of Randia siamensis

    Rapheeporn KHWANCHUEA*a, Chaweewan JANSAKUL*a, Michael J. MULVANY*b, Emerson Ferreira QUEIROZ*c, Kurt HOSTETTMANN*c
    *aDepartment of Physiology, Faculty of Science, Prince of Songkla University, *bDepartment of Pharmacology, Aarrhus University, *cLaboratory of Pharmacognosy and Phytochemistry, Faculty of Sciences, University of Geneva
    Biological & Pharmaceutical Bulletin 30(1): 96-104, 2007.


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  • Changes in Hsp60 Level of the Failing Heart Following Acute Myocardial Infarction and the Effect of Long-Term Treatment with Trandolapril

    Wakako TOGA*a, Kouichi TANONAKA*b, Satoshi TAKEO*b
    *aTsukuba Research Institute, Novartis Pharma K. K., *bDepartment of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
    Biological & Pharmaceutical Bulletin 30(1): 105-110, 2007.


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  • Glycoprotein Isolated from Rhus verniciflua STOKES Inhibits Inflammation-Related Protein and Nitric Oxide Production in LPS-Stimulated RAW 264.7 Cells

    Phil-Sun OH, Sei-Jung LEE, Kye-Taek LIM
    Molecular Biochemistry Laboratory. Biotechnology Research Institute & Center for the Control of Animal Hazards Using Biotecnology (BK21), Chonnam National University
    Biological & Pharmaceutical Bulletin 30(1): 111-116, 2007.


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  • The 5-HT1A Receptor Full Agonist, 8-0H-DPAT Inhibits ACTH-Induced 5-HT2A Receptor Hyperfunction in Rats:Involvement of 5-HT1A Receptors in the DOI-Induced Wet-Dog Shakes in ACTH-Treated Rats

    Yoshihisa KITAMURA*a, *b, Kouhei KITAGAWA*b, Yoshika FUJITANI*b, Kazuhiko SHIBATA*b, Hiroaki ARAKI*c, Toshiaki SENDOU*b, Yutaka GOMITA*b
    *aDepartment of Pharmaceutical Care and Health Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, *bDepartment of Hospital Pharmacy, Okayama University Medical School, *cDivision of Hospital Pharmacy, Ehime University Medical School
    Biological & Pharmaceutical Bulletin 30(1): 117-120, 2007.


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  • Potent Inhibition of Serum-Stimulated Responses in Vascular Smooth Muscle Cell Proliferation by 2-Chloro-3-(4-hexylphenyl)-amino-1,4-naphthoquinone, a Newly Synthesized 1,4-Naphthoquinone Derivative

    Tack-Joong KIM, Yeo-Pyo YUN
    Research Center for Bioresource and Health, College of Pharmacy, Chungbuk National University
    Biological & Pharmaceutical Bulletin 30(1): 121-127, 2007.


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  • Mitochondria-Dependent Apoptosis Induced by Nanoscale Hydroxyapatite in Human Gastric Cancer SGC-7901 Cells

    Xiaojuan CHEN*a, Changsheng DENG*a, Shengli TANG*b, Ming ZHANG*c
    *aDepartment of Gastroenterology, Zhongnan Hospital, Wuhan University, *bDepartment of General Surgery, Zhongnan Hospital, Wuhan University, *cDepartment of Gastroenterology, Drum Tower Hospital of Nanjing
    Biological & Pharmaceutical Bulletin 30(1): 128-132, 2007.


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  • Overproduction of Nε-(Carboxymethyl)lysine-Induced Neovascularization in Cultured Choroidal Explant of Aged Rat

    Shinjiro KOBAYASHI*a, *b, Masaaki NOMURA*a, Tatsuo NISHIOKA*a, Minoru KIKUCHI*a, Akina ISHIHARA*a, Ryoji NAGAI*c, Nobuyoshi HAGINO*d
    *aDepartment of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University, *bOrganization for Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University, *cDepartment of Medical Biochemistry, Kumamoto University, Graduate School of Medical Sciences, *dTulane University Health Sciences Center, Tulane University Hebert Center, Bldg. 30, US-Japan Biomedical Research Laboratories
    Biological & Pharmaceutical Bulletin 30(1): 133-138, 2007.


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  • Styraxoside A Isolated from the Stem Bark of Styrax japonica Inhibits Lipopolysaccharide-Induced Expression of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in RAW 264.7 Cells by Suppressing Nuclear Factor-kappa B Activation

    Kyung-Jin YUN*a, Byung-Sun MIN*b, Ji-Yeon KIM*a, Kyung-Tae LEE*a
    *aDepartment of Pharmaceutical Biochemistry and Kyung-Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung-Hee University, *bCollege of Pharmacy, Catholic University of Deagu
    Biological & Pharmaceutical Bulletin 30(1): 139-144, 2007.


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  • Isoliquiritigenin, One of the Antispasmodic Principles of Glycyrrhiza Ularensis Roots, Acts in the Lower Part of Intestine

    Yuji SATO*a, Ju-Xiu HE*b, Hidemasa NAGAI*b, Tadato TANI*b, *c, Teruaki AKAO*a
    *aGraduate School of Medicine and Pharmaceutical Sciences, University of Toyama, *bInstitute of Natural Medicine, University of Toyama, *c21st Century COE Program, University of Toyama
    Biological & Pharmaceutical Bulletin 30(1): 145-149, 2007.


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  • Immunological Protection against HPV16 E7-Expressing Human Esophageal Cancer Cell Challenge by a Novel HPV16-E6/E7 Fusion Protein Based-Vaccine in a Hu-PBL-SCID Mouse Model

    Yuanzhi LU*a, Zhixin ZHANG*b, Qiao LIU*a, Bo LIU*a, Xinxin SONG*a, Mingrong WANG*c, Xinhua ZHAO*a, Qingzheng ZHAO*a
    *aLaboratory of Cellular and Molecular Biology, Cancer Institute & Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, *cState Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, *bBeijing Blood Center
    Biological & Pharmaceutical Bulletin 30(1): 150-156, 2007.


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  • Pharmacokinetics/Pharmacodynamics of Acetaminophen Analgesia in Japanese Patients with Chronic Pain

    Shigeo SHINODA*a, Takahiko AOYAMA*b, Yukio AOYAMA*a, Sachiko TOMIOKA*c, Yoshiaki MATSUMOTO*b, Yoko OHE*a
    *aSecond Department of Anesthesiology, Toho University School of Medicine, *bDepartment of Clinical Pharmacokinetics, College of Pharmacy, Nihon University, *cLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
    Biological & Pharmaceutical Bulletin 30(1): 157-161, 2007.


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  • Analysis of Relationship between Peak Inspiratory Flow Rate and Amount of Drug Delivered to Lungs Following Inhalation of Fluticasone Propionate with a Diskhaler

    Haruko YOKOYAMA*a, Yoshikazu YAMAMURA*b, Takeshi OZEKI*a, Tatsuji IGA*c, Yasuhiko YAMADA*a
    *aSchool of Pharmacy, Tokyo University of Pharmacy and Life Science, *bDepartment of Hospital Pharmacy, Yokohama Postal Service Agency Hospital, *cInternational University of Health and Welfare
    Biological & Pharmaceutical Bulletin 30(1): 162-164, 2007.


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  • Clematis huchouensis TAMURA:A Traditional Chinese Herbal Medicine and Its Quality Control Using a High Performance Liquid Chromatography Technique

    Muhammad Ishtiaq CHAUDHARY, He QING, Pei Gen XIAO, YiYu CHENG
    Department of Chinese Medicine Science and Engineering, College of Pharmaceutical Sciences, Institute of Bioinformatics, Zhejiang University
    Biological & Pharmaceutical Bulletin 30(1): 165-168, 2007.


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  • Characterization of Biosurfactant-Containing Liposomes and Their Efficiency for Gene Transfection

    Yoshinobu UENO*a, Naohide HIRASHIMA*a, Yoshikazu INOH*a, *b, Tadahide FURUNO*a, *b, Mamoru NAKANISHI*a, *b
    *aGraduate School of Pharmaceutical Sciences, Nagoya City University, *bSchool of Pharmacy, Aichi Gakuin University
    Biological & Pharmaceutical Bulletin 30(1): 169-172, 2007.


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  • Molecular Authentication of Radix Puerariae Lobatae and Radix Puerariae Thomsonii by ITS and 5S rRNA Spacer Sequencing

    Ye SUN*a, *b, Pang-Chui SHAW*a, Kwok-Pui FUNG*a
    *aDepartment of Biochemistry and Institute of Chinese Medicine, The Chinese University of Hong Kong, *bSouth China Botanical Garden, The Chinese Academy of Sciences
    Biological & Pharmaceutical Bulletin 30(1): 173-175, 2007.


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  • Inhibitory Effects of Asiatic Acid on 7,12-Dimethylbenz[a]anthracene and 12-O-Tetradecanoylphorbol 13-Acetate-Induced Tumor Promotion in Mice

    Byung Chul PARK, Seung-Hwan PAEK, Yoon-Seok LEE, Seung-Joo KIM, Eung-Seok LEE, Han Gon CHOI, Chul Soon YONG, Jung-Ae KIM
    College of Pharmacy, Yeungnam University,
    Biological & Pharmaceutical Bulletin 30(1): 176-179, 2007.


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  • A New 2-Imino-1,3-thiazoline Derivative, KHG22394 Inhibits Melanin Synthesis in Mouse B16 Melanoma Cells

    Dong-Seok KIM*a, *b, Yun-Mi JEONG*a, Ik-Kyu PARK*c, Hoh-Gyu HAHN*c, Hyun-Kyung LEE*a, Sun-Bang KWON*a, Ji Hoon JEONG*b, Sung Jun YANG*d, Uy Dong SOHN*d, Kyoung-Chan PARK*a
    *aDepartment of Dermatology, Seoul National University College of Medicine, *bCollege of Medicine, Chung-Ang University, *cOrganic Chemistry Laboratory, Korea Institute of Science & Technology, *dDepartment of Pharmacology, College of Pharmacy, Chung Ang University
    Biological & Pharmaceutical Bulletin 30(1): 180-183, 2007.


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  • Antifungal Effect of Eugenol and Nerolidol against Microsporum gypseum in a Guinea Pig Model

    Sook-Jin LEE*a, Je-Ik HAN*a, Geun-Shik LEE*b, Mi-Jin PARK*c, In-Gyu CHOI*c, Ki-Jeong NA*a, Eui-Bae JEUNG*b
    *aLaboratory of Veterinary Clinical Pathology, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, *bLaboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, *cDepartment of Forest Products, College of Agriculture and Life Sciences, Seoul National University
    Biological & Pharmaceutical Bulletin 30(1): 184-188, 2007.


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  • Protective Effect of (4-Methoxybenzylidene)-(3-methoxynophenyl)amine against Neuronal Cell Death Induced by Oxygen and Glucose Deprivation in Rat Organotypic Hippocampal Slice Culture

    Sang Yoon CHOI*a, Sanghee KIM*b, Dongwook SON*c, Pyeongjae LEE*d, Jongseok LEE*e, Sanghyun LEE*f, Dong Soo KIM*a, Yongkon PARK*a, Sun Yeou KIM*e
    *aKorea Food Research Institute, *bCollege of Pharmacy, Seoul National University, *cKT&G Central Research Institute, *dDepartment of Natural Medicine Resources, Semyung University, *eGraduate School of East-West Medical Science, Kyung Hee University, *fCollege of Industrial Science, Chung-Ang University
    Biological & Pharmaceutical Bulletin 30(1): 189-192, 2007.


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  • In Vitro Study for Inhibition of NO Production about Constituents of Sappan Lignum

    Yohei SASAKI, Tomokazu HOSOKAWA, Masahiro NAGAI, Seiji NAGUMO
    Department of Medicinal Plant Sciences, Hoshi University
    Biological & Pharmaceutical Bulletin 30(1): 193-196, 2007.


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  • In Vitro and in Vivo Antiallergic Effect of the Fructus of Evodia rutaecarpa and Its Constituents

    Yong-Wook SHIN*a, Eun-Ah BAE*a, Xing Fu CAI*b, Jung Joon LEE*b, Dong-Hyun KIM*a
    *aCollege of Pharmacy, Kyung Hee University, *bKorea Research Institute of Bioscience and Biotechnology
    Biological & Pharmaceutical Bulletin 30(1): 197-199, 2007.


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  • Differential Effects of Antioxidants on the In Vitro Invasion, Growth and Lung Metastasis of Murine Colon Cancer Cells

    Masaru OGASAWARA, Takayuki MATSUNAGA, Hideyo SUZUKI
    Toyama Prefectural Institute for Pharmaceutical Research
    Biological & Pharmaceutical Bulletin 30(1): 200-204, 2007.


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  • Human Acyl-CoA:Cholesterol Acyltransferase Inhibitory Activities of Aliphatic Acid Amides from Zanthoxylum piperitum DC.

    Yong Dae PARK*a,*b, Woo Song LEE*a,*b, Sojin AN*a, Tae-Sook JEONG*a,*b
    *aNational Research Laboratory of Lipid Metabolism & Atherosclerosis, KRIBB, *bMolecular Science, University of Science and Technology
    Biological & Pharmaceutical Bulletin 30(1): 205-207, 2007.


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  • Characterization of Novel Mixed Polyethyleneglycol Modified Liposomes

    Ikumi SUGIYAMA, Yasuyuki SADZUKA
    School of Pharmaceutical Sciences, University of Shizuoka
    Biological & Pharmaceutical Bulletin 30(1): 208-211, 2007.


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book
発行元:
日本薬学会
ISSN:
0918-6158
ISSN(オンライン):
1347-5215

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開始頁:
Medical Online English Site