バックナンバー:Biological and Pharmaceutical Bulletin

Biological and Pharmaceutical Bulletin
42巻 3号

  • Drug Discovery : Recent Progress and the Future Foreword

    Akira Otaka
    Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University
    Biological and Pharmaceutical Bulletin 42(3): 303-303, 2019.


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  • Advances in CRISPR/Cas9 Technology for in Vivo Translation

    Yagiz Anil Cicek(a), David C. Luther(b), Jessica A. Kretzmann(b),(c), Vincent M. Rotello(b)
    (a)Department of Chemistry, Middle East Technical University(METU), (b)Department of Chemistry, University of Massachusetts, (c)School of Molecular Sciences, The University of Western Australia
    Biological and Pharmaceutical Bulletin 42(3): 304-311, 2019.


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  • Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies

    Tomoki Yamashita(a), Kazuo Takayama(a),(b),(c), Mika Hori(d), Mariko Harada-Shiba(d), Hiroyuki Mizuguchi(a),(c),(e)
    (a)Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, (b)PRESTO, Japan Science and Technology Agency, (c)Laboratory of Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition, (d)Department of Molecular Innovation in Lipidology, National Cerebral and Cardiovascular Center Research Institute, (e)Global Center for Medical Engineering and Informatics, Osaka University
    Biological and Pharmaceutical Bulletin 42(3): 312-318, 2019.


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  • Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke

    Tatsuya Fukuta(a),(b), Takayuki Ishii(a), Tomohiro Asai(a), Naoto Oku(a),(c)
    (a)Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, (b)Department of Pharmaceutical Health Chemistry, Graduate School of Biomedical Sciences, Tokushima University, (c)Faculty of Pharma-Science, Teikyo University
    Biological and Pharmaceutical Bulletin 42(3): 319-326, 2019.


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  • Utility of Chimeric Mice with Humanized Liver for Predicting Human Pharmacokinetics in Drug Discovery : Comparison with in Vitro-in Vivo Extrapolation and Allometric Scaling

    Yoichi Naritomi(a), Seigo Sanoh(b), Shigeru Ohta(b),†
    (a)Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma Inc., (b)Graduate School of Biomedical and Health Sciences, Hiroshima University, †Present address:Wakayama Medical University
    Biological and Pharmaceutical Bulletin 42(3): 327-336, 2019.


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  • Recent Advances in Liquid Biopsy in Precision Oncology Research

    Yoshiharu Sato(a), Ryo Matoba(a), Kikuya Kato(b)
    (a)DNA Chip Research Inc., (b)Laboratory of Medical Genomics in Nara Institute of Science and Technology
    Biological and Pharmaceutical Bulletin 42(3): 337-342, 2019.


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  • Adeno Associated Virus (AAV) as a Tool for Clinical and Experimental Delivery of Target Genes into the Mammalian Retina

    Tesshu Hori(a), Masashi Fukutome(b), Chieko Koike(a),(b),(c)
    (a)Laboratory for Systems Neuroscience and Developmental Biology, College of Pharmaceutical Sciences, Ritsumeikan University, (b)Graduate School of Life Sciences, Ritsumeikan University, (c)Center for Systems Vision Science, Research Organization of Science and Technology, Ritsumeikan University
    Biological and Pharmaceutical Bulletin 42(3): 343-347, 2019.


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  • Prediction of Human Hepatic Clearance for Cytochrome P450 Substrates via a New Culture Method Using the Collagen Vitrigel Membrane Chamber and Fresh Hepatocytes Isolated from Liver Humanized Mice

    Ryuji Watari(a),(b), Motoharu Kakiki(a), Chihiro Yamasaki(c), Yuji Ishida(c), Chise Tateno(c), Yukie Kuroda(d), Seiichi Ishida(d), Kazutomi Kusano(a)
    (a)Drug Metabolism and Pharmacokinetics Tsukuba, Global Drug Metabolism and Pharmacokinetics, Biopharmaceutical Assessments Core Function Unit, Medicine Development Center, Eisai Co.,Ltd., (b)Department of Genomics-Based Drug Discovery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, (c)R&D Department, PhoenixBio Co.,Ltd., (d)Division of Pharmacology, National Institute of Health Sciences
    Biological and Pharmaceutical Bulletin 42(3): 348-353, 2019.


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  • Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse

    Yuko Yamakage(a), Hitomi Tsuiji(a), Takao Kohno(a), Himari Ogino(a), Takashi Saito(b), Takaomi C. Saido(b), Mitsuharu Hattori(a)
    (a)Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, (b)Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science
    Biological and Pharmaceutical Bulletin 42(3): 354-356, 2019.


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  • A Direct Quantitative Analysis of Erythrocyte Intracellular Ionized Magnesium in Physiological and Pathological Conditions

    Wenxiang Xiong(a),(b), Yaru Liang(a), Xue Li(a), Guosong Liu(a), Zhao Wang(a)
    (a)MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, (b)Center for Drug Evaluation, National Medical Products Administration
    Biological and Pharmaceutical Bulletin 42(3): 357-364, 2019.


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  • Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats

    Fumiyoshi Kasahara(a),(b), Takako Kato(a),(c), Yoko Idota(a),(c), Hitoe Takahashi(a),(c), Chihaya Kakinuma(a), Kentaro Yano(a), Hiroshi Arakawa(d), Kurt Hara(b), Chihiro Miyajima(b), Takuo Ogihara(a),(e)
    (a)Faculty of Pharmacy, Takasaki University of Health and Welfare, (b)Kimica Corporation, (c)Kendai Translational Research Center, (d)Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, (e)Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare
    Biological and Pharmaceutical Bulletin 42(3): 365-372, 2019.


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  • Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans

    Kensuke Mohri(a),(b), Hirofumi Misu(a),(c), Hiroaki Takayama(a),(b), Kiyo-aki Ishii(a),(b), Akihiro Kikuchi(a), Fei Lan(b),(d), Yasufumi Enyama(a),(b), Yumie Takeshita(b), Yoshiro Saito(e),(f), Shuichi Kaneko(b), Toshinari Takamura(a)
    (a)Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, (b)Department of System Biology, Kanazawa University Graduate School of Medical Sciences, (c)PRESTO, Japan Science and Technology Agency, (d)Department of Endocrinology and Metabolism, Chengdu First People's Hospital, (e)Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, (f)Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University
    Biological and Pharmaceutical Bulletin 42(3): 373-378, 2019.


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  • The Ameliorating Effects of Bee Pollen on Scopolamine-Induced Cognitive Impairment in Mice

    Yulan Liao(a), Ho Jung Bae(a), Jiabao Zhang(a), Yubeen Kwon(a), Bokyung Koo(a), In Ho Jung(a), Hye Min Kim(b), Jong Hun Park(c), Jae Hwan Lew(c), Jong Hoon Ryu(a),(d)
    (a)Department of Life and Nanopharmaceutical Science, Kyung Hee University, (b)Daehwa Pharmaceutical Co.,Ltd., (c)Graduate School of East-West Medical Science, Kyung Hee University, (d)Department of Oriental Pharmaceutical Science, Kyung Hee University
    Biological and Pharmaceutical Bulletin 42(3): 379-388, 2019.


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  • Adherence and Concomitant Medication Use among Patients on Warfarin Therapy : Insight from a Large Pharmacy Dispensing Database in Japan

    Masato Takeuchi(a), Sayuri Nakano(a), Sachiko Tanaka-Mizuno(a),(b), Chika Nishiyama(a),(c), Yuko Doi(d), Masaru Arai(e), Yosuke Fujii(d), Toshiyuki Matsunaga(e), Koji Kawakami(a)
    (a)Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, (b)Department of Medical Statistics, Shiga University of Medical Science, (c)Department of Critical Care Nursing, Graduate School of Human Health Science, Kyoto University, (d)Ain Holdings Inc., (e)Kraft Inc.
    Biological and Pharmaceutical Bulletin 42(3): 389-393, 2019.


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  • Hyperbaric Oxygen Combined with 5-Aminolevulinic Acid Photodynamic Therapy Inhibited Human Squamous Cell Proliferation

    Li-Hong Mei, Gao Yang, Fang Fang†
    Department of Dermatological, Jinshan Hospital Affiliated to Fudan University, †Present address:Department of Dermatological, Shanghai Eighth People's Hospital
    Biological and Pharmaceutical Bulletin 42(3): 394-400, 2019.


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  • Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain

    Takumi Iwasawa(a), Takahisa Shinomiya(a), Nozomi Ota(b), Natsumi Shibata(b), Kenya Nakata(c), Isamu Shiina(b), Yukitoshi Nagahara(a)
    (a)Graduate School of Advanced Science and Technology, Tokyo Denki University, (b)Faculty of Science, Tokyo University of Science, (c)Graduate School of Science and Engineering, Shimane University
    Biological and Pharmaceutical Bulletin 42(3): 401-410, 2019.


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  • Expression of Active Staphylococcus aureus Tyrosine Kinases in a Human Cell Line

    Hidesuke Fukazawa, Mari Fukuyama, Yoshitsugu Miyazaki
    Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases
    Biological and Pharmaceutical Bulletin 42(3): 411-416, 2019.


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  • Expression and Characterization of the Human Intestinal Bacterial Enzyme Which Cleaves the C-Glycosidic Bond in 3"-Oxo-puerarin

    Kenichi Nakamura(a), Shu Zhu(b), Katsuko Komatsu(b), Masao Hattori(b), Makoto Iwashima(a)
    (a)Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, (b)Institute of Natural Medicine, University of Toyama
    Biological and Pharmaceutical Bulletin 42(3): 417-423, 2019.


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  • Chemical Constituents from Leaves of Hydrangea serrata and Their Anti-photoaging Effects on UVB-Irradiated Human Fibroblasts

    Ji-Sun Shin(a), Hee-Soo Han(a),(b), Seung-Bin Lee(a),(b), Da-bin Myung(a),(b), Keunsuk Lee(c), Sun Hee Lee(c), Hyoung Ja Kim(d), Kyung-Tae Lee(a),(b)
    (a)Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, (b)Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, (c)Department of New Material Development, COSMAXBIO, (d)Molecular Recognition Research Center, Materials and Life Science Research Division, Korea Institute of Science and Technology
    Biological and Pharmaceutical Bulletin 42(3): 424-431, 2019.


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  • A Network Pharmacology Approach Used to Estimate the Active Ingredients of Moutan Cortex Charcoal and the Potential Targets in Hemorrhagic Diseases

    Shuiqing Li(a),(b),(c), Xingyang Xue(d), Xiaolu Yang(a),(b),(c), Sujuan Zhou(e), Shumei Wang(a),(b),(c), Jiang Meng(a),(b),(c)
    (a)Department of Traditional Chinese Medicine, Guangdong Pharmaceutical University, (b)The Key Unit of Chinese Medicine Digitalization Quality Evaluation of State Administration of TCM, (c)The Research Center for Quality Engineering Technology of TCM, (d)Guangzhou Medical University Cancer Hospital and Institute, (e)College of Medical Information Engineering, Guangdong Pharmaceutical University
    Biological and Pharmaceutical Bulletin 42(3): 432-441, 2019.


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  • Fucoidan Promotes Apoptosis and Inhibits EMT of Breast Cancer Cells

    Xinjia He(a),(b),(c), Meilan Xue(d), Shu Jiang(e), Weiwei Li(d), Jinming Yu(b), Shuai Xiang(d)
    (a)School of Medicine, Shandong University, (b)Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, (c)Department of Radiation Oncology, Affiliated Hospital of Qingdao University Medical College, (d)Department of Biochemistry and Molecular Biology, Basic Medical College, Qingdao University of Medicine, (e)The Affiliated Hospital of Qingdao University
    Biological and Pharmaceutical Bulletin 42(3): 442-447, 2019.


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  • Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer

    Mari Ishigami-Yuasa(a), Hisao Ekimoto(b), Hiroyuki Kagechika(a)
    (a)Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), (b)TMRC Co.,Ltd.
    Biological and Pharmaceutical Bulletin 42(3): 448-452, 2019.


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  • Histone Deacetylase Inhibitor SAHA Treatment Prevents the Development of Heart Failure after Myocardial Infarction via an Induction of Heat-Shock Proteins in Rats

    Shiho Nagata, Tetsuro Marunouchi, Kouichi Tanonaka
    Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences
    Biological and Pharmaceutical Bulletin 42(3): 453-461, 2019.


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  • Panax notoginseng Saponins Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155

    Lanqing Meng, Jun Lin, Qing Huang, Ping Liang, Jianmin Huang, Chongdong Jian, Chong Lin, Xuebin Li
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
    Biological and Pharmaceutical Bulletin 42(3): 462-467, 2019.


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  • Th2 and Th17 Induce Dry Skin in a Mouse Model of Arthritis

    Kenji Goto(a),(b), Keiichi Hiramoto(b), Kazuya Ooi(a),(b)
    (a)Laboratory of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, (b)Laboratory of Pathophysiology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science
    Biological and Pharmaceutical Bulletin 42(3): 468-474, 2019.


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  • Juglone Inhibits Proliferation of HPV-Positive Cervical Cancer Cells Specifically

    Xingyu Zhao, Xiaoxing Song, Jierui Zhao, Wenhe Zhu, Jiancheng Hou, Yanchun Wang, Wei Zhang
    Department of Biochemistry, Basic Medical College of Jilin Medical University
    Biological and Pharmaceutical Bulletin 42(3): 475-480, 2019.


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  • Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc

    Mai Nagasaka(a), Kaori Tsuzuki(a), Yu Ozeki(a), Muneshige Tokugawa(a), Nobumichi Ohoka(c), Yasumichi Inoue(a),(b), Hidetoshi Hayashi(a),(b)
    (a)Department of Cell Signaling, Graduate School of Pharmaceutical Sciences, Nagoya City University, (b)Department of Innovative Therapeutics Sciences, Cooperative Major in Nanopharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, (c)Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences
    Biological and Pharmaceutical Bulletin 42(3): 481-488, 2019.


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  • Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells

    Niraj Chaudhary(a),(b), Keiko Ueno-Shuto(c), Tomomi Ono(a), Yuko Ohira(a), Kenji Watanabe(d), Aoi Nasu(a), Haruka Fujikawa(a),(b), Ryunosuke Nakashima(a), Noriki Takahashi(a), Mary Ann Suico(a), Hirofumi Kai(a), Tsuyoshi Shuto(a)
    (a)Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, (b)Program for Leading Graduate School of "HIGO (Health Life, Science: Interdisciplinary and Global Oriented) Program," Kumamoto University, (c)Laboratory of Pharmacology, Division of Life Science, Faculty of Pharmaceutical Sciences, Sojo University, (d)Institute of Gene Research, Yamaguchi University Science Research Center
    Biological and Pharmaceutical Bulletin 42(3): 489-495, 2019.


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  • Effects of Morinda citrifolia on Rheumatoid Arthritis in SKG Mice

    Dyah Aninta Kustiarini(a),(b), Toshiaki Nishigaki(c), Hiroyuki Kanno(c), Hideto To(a)
    (a)Department of Medical Pharmaceutics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, (b)Centre for Agro-Based Industry, (c)Department of Pathology, School of Medicine, Shinshu University
    Biological and Pharmaceutical Bulletin 42(3): 496-500, 2019.


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  • In Vivo Study on Mechanism Underlying Increased Pharmacological Effects of Phenobarbital in Rats with Glycerol-Induced Acute Renal Failure

    Atsuyoshi Okada, Keiichiro Suzuki, Keisuke Hara, Moeko Kojina, Tetsuya Aiba
    Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
    Biological and Pharmaceutical Bulletin 42(3): 501-506, 2019.


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  • In Vitro Pharmacological Profile of Ipragliflozin, a Sodium Glucose Co-transporter 2 Inhibitor

    Toshiyuki Takasu, Masanori Yokono, Atsuo Tahara, Shoji Takakura
    Drug Discovery Research Astellas Pharma Inc.
    Biological and Pharmaceutical Bulletin 42(3): 507-511, 2019.


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  • Evaluation of in Vitro Bactericidal Activity of 1.5% Olanexidine Gluconate, a Novel Biguanide Antiseptic Agent

    Shoji Seyama(a),†, Hisae Nishioka(b), Hidemasa Nakaminami(a), Keisuke Nakase(a), Takeaki Wajima(a), Akifumi Hagi(b), Norihisa Noguchi(a)
    (a)Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, (b)Naruto Research Institute, Research and Development Center, Otsuka Pharmaceutical Factory, Inc., †Present address:Department of Pharmacy, Keio University Hospital
    Biological and Pharmaceutical Bulletin 42(3): 512-515, 2019.


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book
発行元:
日本薬学会
ISSN:
0918-6158
ISSN(オンライン):
1347-5215

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