バックナンバー:Chemical and Pharmaceutical Bulletin

Chemical and Pharmaceutical Bulletin
66巻 3号

  • Current Topics Drug Discovery : Recent Progress and the Future Foreword

    Akira Otaka
    Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University
    Chemical and Pharmaceutical Bulletin 66(3): 189-190, 2018.


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  • Dengue Virus and Its Inhibitors : A Brief Review

    Yu-Shi Tian(a), Yi Zhou(a), Tatsuya Takagi(a), Masanori Kameoka(b), Norihito Kawashita(a),(c)
    (a)Graduate School of Pharmaceutical Sciences, Osaka University, (b)Department of International Health, Kobe University Graduate School of Health Sciences, (c)Faculty of Sciences and Engineering, Kindai University
    Chemical and Pharmaceutical Bulletin 66(3): 191-206, 2018.


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  • Supramolecular Pharmaceutical Sciences : A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules

    Taishi Higashi(a), Daisuke Iohara(b), Keiichi Motoyama(a), Hidetoshi Arima(a),(c)
    (a)Graduate School of Pharmaceutical Sciences, Kumamoto University, (b)Faculty of Pharmaceutical Sciences, Sojo University, (c)Program for Leading Graduate Schools "HIGO (Health Life Science: Interdisciplinary and Glocal Oriented) Program," Kumamoto University
    Chemical and Pharmaceutical Bulletin 66(3): 207-216, 2018.


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  • A Novel Approach to the Treatment of Plasma Protein Deficiency : Ex Vivo-Manipulated Adipocytes for Sustained Secretion of Therapeutic Proteins

    Masayuki Kuroda(a), Yasushi Saito(b), Masayuki Aso(c), Koutaro Yokote(d)
    (a)Center for Advanced Medicine, Chiba University Hospital, Chiba University, (b)Hospital Bureau, (c)CellGenTech, Inc., (d)Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba University
    Chemical and Pharmaceutical Bulletin 66(3): 217-224, 2018.


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  • Establishment of a Patient-Derived Tumor Xenograft Model and Application for Precision Cancer Medicine

    Seiji Okada(a), Kulthida Vaeteewoottacharn(a),(b), Ryusho Kariya(a)
    (a)Center for AIDS Resesarch, Kumamoto University, (b)Department of Biochemistry, Faculty of Medicine, Khon Kaen University
    Chemical and Pharmaceutical Bulletin 66(3): 225-230, 2018.


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  • Boron-Catalyzed Carboxylic Acid-Selective Aldol Reaction with Trifluoromethyl Ketones

    Kouhei Ishizawa(a),(b), Hideoki Nagai(a), Yohei Shimizu(a), Motomu Kanai(a)
    (a)Graduate School of Pharmaceutical Sciences, The University of Tokyo, (b)Sohyaku Innovative Research Division, Mitsubishi Tanabe Pharma Corporation
    Chemical and Pharmaceutical Bulletin 66(3): 231-234, 2018.


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  • Discovery of a Novel Fluoroquinolone Antibiotic Candidate WFQ-228 with Potent Antimicrobial Activity and the Potential to Overcome Major Drug Resistance

    Tatsuya Hirano, Tomohiko Kinoshita, Daichi Kazamori, Satoshi Inoue, Kouji Nishimura, Asuka Sakurai, Kensuke Ohishi, Yasuhiro Kuramoto, Hirotaka Amano, Akira Yazaki
    Drug Discovery Laboratory, Wakunaga Pharmaceutical Co.,Ltd.
    Chemical and Pharmaceutical Bulletin 66(3): 235-238, 2018.


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  • Dihydroorotate Dehydrogenase as a Target for the Development of Novel Helicobacter pylori-Specific Antimicrobials

    Tomokazu Ohishi(a), Daniel Ken Inaoka(b), Kiyoshi Kita(b), Manabu Kawada(a),(c)
    (a)Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, (b)School of Tropical Medicine and Global Health, Nagasaki University, (c)Institute of Microbial Chemistry (BIKAKEN), Laboratory of Oncology, Microbial Chemistry Research Foundation
    Chemical and Pharmaceutical Bulletin 66(3): 239-242, 2018.


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  • Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor

    Yoichi Kadoh(a), Haruko Miyoshi(b), Takehiko Matsumura(a), Yoshihito Tanaka(b), Mitsuya Hongu(b), Mayumi Kimura(a), Kei Takedomi(a), Kenji Omori(b),(c), Jun Kotera(b), Takashi Sasaki(b), Tamaki Kobayashi(b), Hiroyuki Taniguchi(b), Yumi Watanabe(a), Koki Kojima(b), Toshiaki Sakamoto(a), Toshiyuki Himiyama(a), Eiji Kawanishi(a)
    (a)Mitsubishi Tanabe Pharma Corporation, (b)Mitsubishi Tanabe Pharma Corporation, (c)Industry and Academia Cooperation Research Project, Laboratory of Target and Drug Discovery, Graduate School of Pharmaceutical Sciences, Nagoya University
    Chemical and Pharmaceutical Bulletin 66(3): 243-250, 2018.


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  • Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026) , a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor

    Kazuhiko Iikubo, Yutaka Kondoh†, Itsuro Shimada, Takahiro Matsuya, Kenichi Mori, Yoko Ueno, Minoru Okada‡
    Drug Discovery Research, Astellas Pharma Inc., †Present address:Research and Development Dept., Omnica Co.,Ltd., ‡Present address:Technology Department, Yonezawa Hamari Chemicals, Ltd.
    Chemical and Pharmaceutical Bulletin 66(3): 251-262, 2018.


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  • The Effect of Compaction Force on the Transition to Hydrate of Anhydrous Aripiprazole

    Taichiro Togo, Toshiya Taniguchi, Yoshitaka Nakata
    Pharmaceutical Research Center Formulation Research, OHARA Pharmaceutical Co.,Ltd.
    Chemical and Pharmaceutical Bulletin 66(3): 263-269, 2018.


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  • Fluorescent Imaging Analysis for Distribution of Fluorescent Dye Labeled- or Encapsulated-Liposome in Monocrotaline-Induced Pulmonary Hypertension Model Rat

    Yo Muraki(a), Midori Yamasaki(a), Hirohisa Takeuchi(b), Kimio Tohyama(a), Noriyasu Sano(a), Takanori Matsuo(a)
    (a)Takeda Pharmaceutical Company Limited, (b)Takeda Pharmaceutical Company Limited
    Chemical and Pharmaceutical Bulletin 66(3): 270-276, 2018.


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  • Supramolecular Complex of Methyl-β-cyclodextrin with Adamantane-Grafted Hyaluronic Acid as a Novel Antitumor Agent

    Khaled Mohamed Elamin(a), Yuki Yamashita(a), Taishi Higashi(a), Keiichi Motoyama(a), Hidetoshi Arima(a),(b)
    (a)Department of Physical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, (b)Program for Leading Graduate Schools "HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program," Kumamoto University
    Chemical and Pharmaceutical Bulletin 66(3): 277-285, 2018.


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  • Fragment-Based Discovery of Pyrimido[1,2-b]indazole PDE10A Inhibitors

    Ayaka Chino, Ryushi Seo, Yasushi Amano, Ichiji Namatame, Wataru Hamaguchi, Kazuya Honbou, Takuma Mihara, Mayako Yamazaki, Masaki Tomishima, Naoyuki Masuda
    Drug Discovery Research, Astellas Pharma Inc.
    Chemical and Pharmaceutical Bulletin 66(3): 286-294, 2018.


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  • Biomass Potential of Virgin and Calcined Tapioca (Cassava Starch) for the Removal of Sr(II) and Cs(I) from Aqueous Solutions

    Fumihiko Ogata(a), Noriaki Nagai(a), Erimi Ueta(a), Takehiro Nakamura(a), Naohito Kawasaki(a),(b)
    (a)Faculty of Pharmacy, Kindai University, (b)Antiaging Center, Kindai University
    Chemical and Pharmaceutical Bulletin 66(3): 295-302, 2018.


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  • Development of Triazine-Based Benzylating Reagents Possessing t-Butyl Group on the Triazine Core : Thermally Controllable Reagents for the Initiation of Reaction

    Yukiko Karuo, Kohei Yamada, Munetaka Kunishima
    Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University
    Chemical and Pharmaceutical Bulletin 66(3): 303-308, 2018.


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  • Synthesis of Novel Thiophene, Thiazole and Coumarin Derivatives Based on Benzimidazole Nucleus and Their Cytotoxicity and Toxicity Evaluations

    Rafat Milad Mohareb(a), Amira Elsayed Mahmoud Abdallah(b), Abeer Abdelazeem Mohamed(c)
    (a)Department of Chemistry, Faculty of Science, Cairo University, (b)Department of Chemistry, Faculty of Science, Helwan University, (c)National Organization for Research & Control of Biologicals
    Chemical and Pharmaceutical Bulletin 66(3): 309-318, 2018.


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  • Preparative Separation of High-Purity Dihydroartemisinic Acid from Artemisinin Production Waste by Combined Chromatography

    Shuoqian Liu(a),(b), Jorge Freire da Silva Ferreira(c), Dongming Tian(b), Yuwei Tang(a), Liping Liu(a), Wei Yang(b), Zhonghua Liu(a),(b), Na Tian(a)
    (a)Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University, (b)National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, (c)U.S. Salinity Laboratory, United States Department of Agriculture Agricultural Research Service
    Chemical and Pharmaceutical Bulletin 66(3): 319-326, 2018.


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  • Design of a Topically Applied Gel Spray Formulation with Ivermectin Using a Novel Low Molecular Weight Gelling Agent, Palmitoyl-Glycine-Histidine, to Treat Scabies

    Sabrina Dahlizar(a),(b), Mika Futaki(c), Akie Okada(a), Wesam Radhi Kadhum(c), Hiroaki Todo(a),(c), Kenji Sugibayashi(a),(c)
    (a)Graduate School of Pharmaceutical Sciences, Josai University, (b)Department of Pharmacy, Faculty of Medical and Health Science, Syarif Hidayatullah State Islamic University Jakarta, (c)Faculty of Pharmacy and Pharmaceutical Sciences, Josai University
    Chemical and Pharmaceutical Bulletin 66(3): 327-333, 2018.


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  • Synthesis of 3β-tert-Butyldimethylsiloxy-22-phenylthio-23,24-bisnorchola-5,9(11)-diene and Reductive Nucleophilic Attack on a Branched Aliphatic Aldehyde

    Toshiya Nagai, Kengo Hanaya, Shuhei Higashibayashi, Mitsuru Shoji†, Takeshi Sugai
    Department of Pharmaceutical Science, Keio University, †Present address:Faculty of Pharmacy, Yokohama University of Pharmacy
    Chemical and Pharmaceutical Bulletin 66(3): 334-338, 2018.


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book
発行元:
日本薬学会
ISSN:
0009-2363
ISSN(オンライン):
1347-5223

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開始頁:
Medical Online English Site