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Journal of Toxicologic Pathology 20巻 suppl号

発行元
日本毒性病理学会
ISSN
0914-9198
ISSN（オンライン）
1881-915X
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開始頁
S1-1 Time-related changes in potential factors involved in hepatocarcinogenesis by DDT in rats following chronic exposure
Takanori HARADA, Ryoichi OHTSUKA, Makio TAKEDA, Naruto TOMIYAMA, Sayuri KOJIMA, Naofumi TAKAHASHI, Toshinori YOSHIDA, Akiko ENOMOTO, Nobuaki NAKASHIMA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 20 (suppl) 1-1, 2007.
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S1-2 Induction of ROS and oxidative DNA damage in hepatocarcinogenesis
Hideki WANIBUCHI1), Anna KINOSHITA1), Min WEI1), Keiichirou MORIMURA1), Shoji FUKUSHIMA2)
1)Dept. Pathol., Osaka City Univ. Med. Sch., 2)Japan Bioassay Research Center
Journal of Toxicologic Pathology 20 (suppl) 1-1, 2007.
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S1-3 Nuclear Receptor CAR and Liver Tumor Promotion
Masahiko NEGISHI, Yukio YAMAMOTO, Eric TIEN, Shingo MUTOH, Robert MARONPOT
The Pharmcogenetics Section, National Institute of Environmental Health Sciences, NIH, Research Triangle Park
Journal of Toxicologic Pathology 20 (suppl) 2-2, 2007.
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S1-4 Epigenetic mechanisms of carcinogenesis and detection systems for epigenetic mutagens
Toshikazu USHIJIMA, Eriko OKOCHI-TAKADA
Carcinogenesis Division, National Cancer Center Research Institute
Journal of Toxicologic Pathology 20 (suppl) 2-2, 2007.
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S2-1 Profiling of thyroid carcinogenesis-related phenotype utilizing tissue area-specific expression analysis method
Makoto SHIBUTANI
Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 20 (suppl) 3-3, 2007.
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S2-2 Possible prediction of pathological changes in hepatotoxicity
Mitsuhiro HIRODE
Toxicogenomics Project, National Institute of Biomedical Innovation
Journal of Toxicologic Pathology 20 (suppl) 3-3, 2007.
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S2-3 Development of the short term in vivo prediction system of carcinogenicity.
Hiroshi MATSUMOTO1), Yoshikuni YAKABE1), Masanori OTSUKA1), Yasushi MINOBE1), Hideki MIYAURA1), Fumiyo SAITO1), Koichi SAITO2), Kayo SUMIDA2), Masaru SEKIJIMA3), Koji NAKAYAMA3), Tomoyuki SHIRAI4)
1)Chemicals Evaluation and Research Institute, 2)Sumitomo Chemical Co., Ltd., 3)Mitsubishi Chemical Safety Institute Ltd., 4)Graduate School of Medical Sciences, Nagoya City Univ.
Journal of Toxicologic Pathology 20 (suppl) 4-4, 2007.
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S2-4 Expression profile differences between rats and human treated with chemicals in vitro and in vivo.
Shugo SUZUKI
Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci
Journal of Toxicologic Pathology 20 (suppl) 4-4, 2007.
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WS1-1 Introduction of Workshop I - Recent Issues of Carcinogenic Evaluation of Pharmaceutical Compounds Using Transgenic Mice
Katsumi IMAIDA
Onco-Pathology, Faculty of Medicine, Kagawa University
Journal of Toxicologic Pathology 20 (suppl) 5-5, 2007.
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WS1-2 Susceptibility of Heterozygous and Nullizygous p53 Knockout Mice to Chemical Carcinogens -Tissue Dependence and Role of p53 Gene Mutations-
Tetsuya TSUKAMOTO, Akihiro HIRATA, Masae TATEMATSU
Division of Oncological Pathology, Aichi Cancer Center Research Institute
Journal of Toxicologic Pathology 20 (suppl) 5-5, 2007.
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WS1-3 Usefulness and problems in carcinogenicity evaluation on pharmaceuticals using rasH2 mice
Kunitoshi MITSUMORI1), Meilan JIN1), Miwa TAKAHASHI2)
1)Lab. Vet. Pathol, Fac. Agri., Tokyo Univ. Agri. and Tech., 2)Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 20 (suppl) 6-6, 2007.
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WS1-4 Current Status on Carcinogenicity Assessment of PPAR Agonists by the US FDA and a Mode of Action (MOA) Approach for the Carcinogenic Potentials
Toyohiko AOKI
Drug Safety Research Laboratories, Eisai Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 6-6, 2007.
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WS2-1 Safety assessment of antibody therapeutics
Kiyoshi Kobayashi
Preclinical Department, Amgen K.K.
Journal of Toxicologic Pathology 20 (suppl) 7-7, 2007.
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WS2-2 The current and future status of idiosyncratic drug reactions
Munehiro TERANISHI, Kazuyoshi KUMAGAI, Yoshiro Tani, Kazumi ITO, Kazunori FUJIMOTO, Yosuke ANDO, Takashi YAMOTO, Sunao MANABE
Medicinal Safety Research Laboratories, Sankyo Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 7-7, 2007.
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WS2-3 Topics of the issues for toxicological evaluations in the drug development process；Toxicological Pathology and Drug Evaluation
Hiroshi Onodera
Pharmaceuticals & Medical Devices Agency, Office of New Drug I
Journal of Toxicologic Pathology 20 (suppl) 8-8, 2007.
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O-1 Dental Caries and Periodontal Disease in WBN/Kob Rats-The effects of alloxan and insulin treatment.
Yutaka NAKAHARA1), Tomoya SANO2), Kiyokazu OZAKI2), Tetsurou MATSUURA2), Yoko FUKUZATO3), Isao NARAMA2)
1)Dep. Pathol., Panapharm Laboratories Co., Ltd., 2)Dep. Pathol., Fac. pharm., Setsunan Univ., 3)Sunstar Inc.
Journal of Toxicologic Pathology 20 (suppl) 8-8, 2007.
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O-2 T-2 toxin-induced gastric lesions in mice
Junko SHINOZUKA1), Hiroyuki YUASA1), Wataru TORIUMI1), Kunio DOI2)
1)Exploratory Toxicology and DMPK Research Laboratories, Tanabe Seiyaku Co., Ltd., 2)Department of Veterinary Pathology, Faculty of Agriculture, The University of Tokyo
Journal of Toxicologic Pathology 20 (suppl) 9-9, 2007.
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O-3 Morphogenesis of ocular coloboma during embryogenesis in FLS mice
Katsutoshi KITA, Tetsuro MATSUURA, Kiyokazu OZAKI, Isao NARAMA
Dep. Pathology, Fac. Pharm., Setsunan Univ.
Journal of Toxicologic Pathology 20 (suppl) 9-9, 2007.
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O-4 Gene Expression Profiling of Antineoplastic Platinum Complex, Nedaplatin-Induced Papillary Toxicity in the Rat Kidney
Takeki UEHARA1), Noriko TSUCHIYA1), Manabu OKADA1), Satoshi INOUE1), Mikinori TORII1), Jyoji YAMATE2), Toshiyuki MARUYAMA1)
1)Developmental Research Laboratories, Shionogi & Co., Ltd., 2)Department of Veterinary Pathology, Graduate School of Agriculture and Biological Science, Osaka Prefecture University
Journal of Toxicologic Pathology 20 (suppl) 10-10, 2007.
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O-5 Analysis of oxidative DNA damage and other renal effects of the color components of madder color and their metabolites in relation to the renal carcinogenesis in F344 rats
Kaoru INOUE, Makoto SHIBUTANI, Miwa TAKAHASHI, Mami U, Hitoshi FUJIMOTO, Gye-Hyeong WOO, Takashi UMEMURA, Masao HIROSE
Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 20 (suppl) 10-10, 2007.
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O-6 Role of keeping undifferentiated states on tumor development in mice.
Yasuhiro YAMADA1)2), Konrad HOCHEDLINGER1), Hideki MORI2), Rudolf JAENISCH1)
1)Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, 2)Department of Tumor Pathology, Gifu University Graduate School of Medicine
Journal of Toxicologic Pathology 20 (suppl) 11-11, 2007.
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O-7 In Utero and Lactatinal Exposure of 3, 3', 4, 4', 5-Pentachlorobiphenyl modulate the N-butyl-4-(hydroxybutyl)nitrosamine induced Rat Bladder Carcinogenesis
Ryoji TAKAHASHI1), Shin WAKUI1), Tomoko MUTO2), Kiyofumi YOKOO1), Hitoshi ENDOU2)3), Yoshikatsu KANAI2)
1)Dept. Toxicol. Pathol, Azabu Univ. Sch. Vet. Med., 2)Dept. Phrmacol, Kyorin Univ. Sch. Med., 3)Fuji Biomedix.
Journal of Toxicologic Pathology 20 (suppl) 11-11, 2007.
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O-8 Influence of fatigue on living body：pathological examination for gastric carcinogenesis in a rat model of fatigue
Kenichiro DOI1), Masaaki TANAKA2), Min WEI1), Keiichirou MORIMURA1), Yasuyoshi WATANABE2), Shoji FUKUSHIMA1)3), Hideki WANIBUCHI1)
1)Dept. Pathol, Osaka City Univ. Med. Sch., 2)Dept. Physiol, Osaka City Univ. Med. Sch., 3)Jpn. Bioassay Res. Center
Journal of Toxicologic Pathology 20 (suppl) 12-12, 2007.
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O-9 Gpx2 overexpression in rat and human mammary carcinogenesis
Aya NAIKI-ITO1), Makoto ASAMOTO1), Naomi HOKAIWADO1), Satoru TAKAHASHI1), Hiroko YAMASHITA2), Hiroyuki TSUDA3), Tomoyuki SHIRAI1)
1)Dept. of Exp. Pathol. and Tumor Biol., 2)Dept. of Oncol. and Endocrinol., 3)Dept. of Mol. Toxycol., Nagoya City Univ. Grad. Sch. of Med. Sci.
Journal of Toxicologic Pathology 20 (suppl) 12-12, 2007.
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O-10 Inhibitory effects of BBN induced bladder cancer for LAT1 knock out mouse
Tomoko MUTO1), Yoshikatu KANAI1), Shin WAKUI2), Hitoshi ENDOU1)3)
1)Dept. of Pharmacol. and Toxicol, Kyorin Univ. Sch. of Med., 2)Dept. of Toxicol Path. Azabu Univ. Sch of Vet. Med., 3)Fuji Biomedix Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 13-13, 2007.
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O-11 Possible involvement of oxidative stress in piperonyl butoxide induced hepatocarcinogenesis in rats
Masako MUGURUMA1, Akira UNAMI2, Yuichi KUROIWA3, Jihei NISHIMURA1, Meilan JIN1, Yasuaki DEWA1, Miwa TAKAHASHI3, Mitsuyoshi MOTO1, Yuji OISHI2, Takashi UMEMURA3, Kunitoshi MITSUMORI1
1)Laboratory of Veterinary Pathology, Tokyo Univ. of Agriculture and Technology, 2)Drug Safety Research Lab. Astellas Pharma Inc., 3)Division of Pathology, NIHS
Journal of Toxicologic Pathology 20 (suppl) 13-13, 2007.
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O-12 Resistance of PPARα-humanized mice to Wy-14, 643-induced liver tumorigenesis
Keiichirou MORIMURA1)2), Connie CHEUNG2), Jerrold M. WARD3), Frank J. GONZALEZ2)
1)Dept. Pathol, Osaka City Univ. Med. Sch., 2)Lab. of Metabol., CCR, NCI, NIH, 3)Comparative Medicine Branch, NIAID, NIH
Journal of Toxicologic Pathology 20 (suppl) 14-14, 2007.
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O-13 Generation of Gene Mutation in gpt Delta Rats by the Modification of Food Composition and Its Involvement in Hepatocarcinogenesis with Carcinogenic Mechanism and Strain Differences
Dai NAKAE1)2), Ken'ichi MASUMURA3), Yasuteru SAKAMOTO3), Masakazu TAKAHASHI5), Hideki WANIBUCHI6), Takashi UMEMURA4), Akiyoshi NISHIKAWA4), Masao HIROSE4), Takehiko NOHMI3)
1)Tokyo Metropol. Inst. Publ. Health, 2)Tokyo Univ. Agricul., 3)Gene Mutat., 4)Pathol., Natl. Inst. Health Sci., 5)Former Dept. Pathol., Sasaki Inst., 6)Dept. Pathol., Osaka City Univ. Med. Sch.
Journal of Toxicologic Pathology 20 (suppl) 14-14, 2007.
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O-14 Short Interfering RNA Vector against VEGF-C or VEGF-A Suppresses Lymphatic Metastasis of Murine Mammary Cancer Model
Masa-Aki SHIBATA1), Junji MORIMOTO2), Yoshinori OTSUKI1)
1)Dept. Anatomy and Cell Biol., 2)Lab. Animal Center, Osaka Medical College
Journal of Toxicologic Pathology 20 (suppl) 15-15, 2007.
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O-15 Immunohistochemical profiles of ovarian tumors in B6C3F1 mice exposed to irradiation
Midori Yoshida, Yasushi Omachi
Exp. Rad. Children's Health Res. Gr., Res. Ctr. Rad. Prot., Nafl. Inst. Rad. Sci.
Journal of Toxicologic Pathology 20 (suppl) 15-15, 2007.
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O-16 Modifying effects of antioxidants on oxidative stress and in vivo mutagenicity in gpt delta rats given potassium bromate
Takashi UMEMURA1), Masako TASAKI1), Toshiya OKAMURA1), Yuichi KUROIWA1), Hisayoshi TAKAGI3), Takehiko NOHMI2), Akiyoshi NISHIKAWA1), Masao HIROSE1)
1)Div. of Pathol., 2)Div. of Genetic and Mutagenesis, Natl. Inst. Hlth Sci., 3)Japan SLC, Co. Ltd.
Journal of Toxicologic Pathology 20 (suppl) 16-16, 2007.
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P-1 Spontaneous Glomerular Lesions in Cynomolgus Monkeys
Xiuying Yang, Hiroshi Maeda, Takaharu Nagaoka, Yutaka Chihaya, Yasuhiro Kamimura, Hiroshi Tokado, Hiroaki Miyajima
Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd.
Journal of Toxicologic Pathology 20 (suppl) 16-16, 2007.
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P-2 Spontaneous Glomerular Sclerosis in Aged Cynomolgus Monkeys
Atsuko HARA, Masumi MARUO, Sachiko EBATA, Masao MATSUURA, Ko-ichiro NISHIOKA
Research Laboratories, Nippon Chemiphar Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 17-17, 2007.
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P-3 Histopathological and ultrastructural studies on vacuolar degeneration of thyroid follicular epithelial cells noted in 1 cynomolgus monkey
Hirofumi HATAKEYAMA1), Yoshihiro TAKEI1), Haruko KOIZUMI1), Akihito SHIMOI1), Mitsutoshi WATANABE1), Izuru SUZUKI2), Mamoru NOMURA3)
1)Ina Research Inc., Safety Research Center, Pathology Department, 2)The Kitasato Institute Research Center for Biologicals, 3)Ina Research Inc., Safety Research Center
Journal of Toxicologic Pathology 20 (suppl) 17-17, 2007.
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P-4 Esophageal Foregut Cyst in a Cynomolgus Monkey (Macaca fascicularis)
Yoshimasa OKAZAKI, Masahiro MATSUMOTO, Akiko ANAGAWA, Yuichi MURAKAMI, Kenjiro TSUBOTA, Katsuhiko YOSHIZAWA, Shunji NAKATSUJI, Shiro FUJIHIRA, Yuji OISHI
Drug Safety Research Laboratories, Astellas Pharma Inc.
Journal of Toxicologic Pathology 20 (suppl) 18-18, 2007.
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P-5 A case of cardiac hypertrophy in a nine-week-old Crl：CD(SD)rat
Tomo SUZUKI, Shoichi KADO, Minoru ANDO, Yuriko NAGATA, Shin IWATA, Toshihide KOBAYASHI, Kazumi UCHIDA
Safety Reserch Center, Yakult Central Institute for Microbiological Research
Journal of Toxicologic Pathology 20 (suppl) 18-18, 2007.
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P-6 Cardiac rhabdomyomatosis in Nihon rat, a model for the human Birt-Hogg-Dube syndrome
Yoshiko MICHIMAE1), Kazuo OKIMOTO1), Mami KOUCHI1), Izumi MATSUMOTO1), Tadashi INOUE1), Takaki SEKI1), Masashi YASUBA1), Okio HINO2)
1)Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 2)Department of Molecular Pathogenesis, Juntendo University, School of Medicine
Journal of Toxicologic Pathology 20 (suppl) 19-19, 2007.
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P-7 Ultrastructural Observations of Endometrial Stromal Sarcoma in Donryu Rats
Shunji NAKATSUJI1), Midori YOSHIDA2), Akihiko MAEKAWA3), Yuji OISHI1)
1)Drug Safety Research Labs., Astellas Pharm Inc., 2)National Inst. of Radiological Sciences, 3)National Inst. of Technology and Evaluation
Journal of Toxicologic Pathology 20 (suppl) 19-19, 2007.
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P-8 Histopathological characterization of a drug-induced myocardial vacuolation in mice
Shiro FUJIHIRA1), Yoshimasa OKAZAKI1), Akiko ANAGAWA1), Yuichi MURAKAMI1), Kenjiro TSUBOTA1), Katsuhiko YOSHIZAWA1), Masahiro MATSUMOTO1), Shunji NAKATSUJI1), Yuji OISHI1)
1)Drug Safety Research Laboratories, Astellas Pharma Inc.
Journal of Toxicologic Pathology 20 (suppl) 20-20, 2007.
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P-9 Application of immunohistochemistry in spontaneously observed rhabdomyosarcoma in F344 rat：Usefulness of myogenic regulatory factors(MRFs)
Ayano TAKEUCHI1), Kenji NAKANO1), Shuuji ISHIKAWA1), Mihoko ONO1), Kyoko ITO1), Satoru KAJIKAWA1), Katsuhisa SHIRAKI1), Nobuyuki IZUMISAWA1)
1)Drug Safety Research Laboratories, Astellas Pharma Inc.
Journal of Toxicologic Pathology 20 (suppl) 20-20, 2007.
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P-10 Effects of Alendronate and Prednisolone on a Model of Rheumatoid Arthritis in Mice
Masaharu TANAKA, Mana MITAMURA, Anbo XIANG, Hiroyuki HIGASHIYAMA, Hideo KIKKAWA, Satoshi ASANO
Dept. Pharmacology, TRL, GlaxoSmithKline K.K.
Journal of Toxicologic Pathology 20 (suppl) 21-21, 2007.
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P-11 Effects of Tetrabromobisphenol A, a flame retardant, on the liver of ICR male mice
Yukie TADA, Tomoko FUJITANI, Akio OGATA, Hisashi KAMIMURA
Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health
Journal of Toxicologic Pathology 20 (suppl) 21-21, 2007.
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P-12 Inhibitory Effect of Anti-VEGF antibody on the Growth and Angiogenesis of Estrogen-induced Pituitary Prolactinoma in Fischer 344 Rets
Katsuhiro MIYAJIMA1), Kochi KAKIMOTO1), Susumu TAKEKOSHI2), Yuji YAMAZAKI1), Hanako KAJIYA2), Toshiyuki SHODA1), Toshiki IWASAKA1), Akemi TAKAHASHI1), Yoshifumi MIYAKAWA1), Robert Yoshiyuki OSAMURA2)
1)Toxicology Research Laboratories, JAPAN TOBACCO Inc., 2)Department of Pathology, Tokai University School of Medicine
Journal of Toxicologic Pathology 20 (suppl) 22-22, 2007.
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P-13 Rat Subcutaneous Malignant Fibrous Histiocytoma and Its Tumor Lines, Showing Histiocytic Characteristics
Jyoji YAMATE1), Sei-ichi FUMIMOTO1), Mitsuru KUWAMURA1), Takao KOTANI1), Jonathan LAMARRE2)
1)Vet. Pathol, Osaka Pre. Univ., 2)Bio. Sci., Univ. Guelph, Ontario
Journal of Toxicologic Pathology 20 (suppl) 22-22, 2007.
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P-14 Pathological reference data on primary sites of malignant lymphomas in control B6C3F1 mice from 12 carcinogenecity studies and case reports of rare extranodal lymphoma
Yuzo YASUI, Mari IIDA, Yoshihide UEDA, Kayoko NAGAI, Ryo YAMASHITA, Mayumi ISHIZAKI, Tohru KIHARA, Kazushige HASEGAWA, Masayo HOSOI, Rumiko MIYAJIMA, Atsushi SHIGA, Hijiri IWATA, Kiyoshi IMAI
Pathology Department, An-pyo Center
Journal of Toxicologic Pathology 20 (suppl) 23-23, 2007.
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P-15 Relation between spontaneous hemorrhage and immunoreactivity of the estrogen receptors in the pancreatic islet of male Sprague-Dawley rats with age
Masako IMAOKA1, Mayumi GOTO1, Haruka FUJITA2, Hiroshi SATOH1, Kazuhisa FURUHAMA1
1Drug Safety Research Laboratory, 2Technology Research Center, Daiichi Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 23-23, 2007.
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P-16 Molecular biological evaluation of a differentiation potential of mouse hepatoblastoma into biliary lineage
Tetsuya SAKAIRI, Itsuko IKEDA, Hiroyuki UTSUMI, Shin KOHGE, Jiro SUGIMOTO, Fumiko SANO, Shiro TAKAGI
Toxicology Laboratory, Mitsubishi Pharma Corporation
Journal of Toxicologic Pathology 20 (suppl) 24-24, 2007.
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P-17 Histopathological features of diabetic ocular complications in the Spontaneously Diabetic Torii (SDT) Rat
Toshiyuki SHODA1), Masami SHINOHARA2), Katsuhiro MIYAJIMA1), Toshiki IWASAKA1), Akemi TAKAHASHI1), Kochi KAKIMOTO1), Yoshifumi MIYAKAWA1)
1)Toxicology Research Laboratories, Central pharma-ceutical Research Institute, JAPAN TOBACCO Inc., 2)Department of Pharmacovigilance, Torii Pharmaceutical Co. Ltd.
Journal of Toxicologic Pathology 20 (suppl) 24-24, 2007.
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P-18 Evaluation of the differentiation and migration of immature neurons in rat fetal brain using anti-neuronal class III β-Tublin immunohistochemistry
Makiko KUWAGATA1)2), Tetsuo OGAWA2), Kenji USUMI1), Fumiaki KUMAGAI1), Yoshiaki SAITO1), Tomoko NAGATA1)
1)Lab. Pathology, Hatano Res. Inst., FDSC, 2)Lab. Anatomy I, Sch. Med., Showa Univ.
Journal of Toxicologic Pathology 20 (suppl) 25-25, 2007.
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P-19 Drug-induced transient neurological symptoms and cerebellar Purkinje cell necrosis in rats
Motoko KATSUTA, Masashi TAGAWA, Norio FUKUI, Shigeru HISADA
Safety Research Dept, ASKA Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 25-25, 2007.
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P-20 Naturally Occurring Microphthalmia in Royal College of Surgeons Rats
Miwa YOSHIMI, Osamu KATSUTA
Research & Development Center, Santen Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 26-26, 2007.
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P-21 Development of experimental nonalcoholic steatohepatitis (NASH) model using type 2 diabetes model mice
Takafumi OSHIKATA, Yutaka NAKAHARA, Koshirou KATOKU, Emiko KUWASAKI, Mikio MITSUISHI, Kousuke MORIZUMI, Souta USHIJIMA, Masao HAMAMURA
Panapharm Laboratories Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 26-26, 2007.
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P-22 Progressive morphological changes in pancreatic islets of Type 2 diabetic mellitus animal models.
Masaki YAMAZAKI, Chie KATOH, Hirotake TAKAI, Kenji ADACHI, Atsuhiko KATOH, Masami SUZUKI
Safety Assessment Dept., Chugai Pharmaceutical Co., LTD.
Journal of Toxicologic Pathology 20 (suppl) 27-27, 2007.
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P-23 Immunohistochemical analyses of nephropathy in WBN/Kob rats with diabetes mellitus accelerated by Alloxan and controlled by insulin.
Chinami KIKKAWA, Kiyokazu OZAKI, Tomoya SANO, Tetsuro MATSUURA, Isao NARAMA
Dep. Pathol. Fac. Pharm. Setsunan Univ.
Journal of Toxicologic Pathology 20 (suppl) 27-27, 2007.
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P-24 Candidate Gene Loci for X-irradiation-induced Diabetes in LEA Rats
Keisuke IZUMI, Makoto SATO
Dept. of Mol. and Environ. Pathol., Inst. of Health Biosciences, The Univ. of Tokushima Graduate Sch.
Journal of Toxicologic Pathology 20 (suppl) 28-28, 2007.
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P-25 Morphological effects of compound X as a possible sterol synthesis inhibitor on the palatal development
Koshirou KATOKU1), Yutaka NAKAHARA1), Takafumi OSHIKATA1), Mikio MITSUISHI1), Emiko KUWASAKI1), Masao HAMAMURA1), Takafumi OOTA1), Naoki IKEMI2)
1)Panapharm Laboratories., 2)Ootsuka Chemical.
Journal of Toxicologic Pathology 20 (suppl) 28-28, 2007.
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P-26 Histopathological Examination in Male Rats by Intraperitoneal Injection of Perfluorooctanesulfonic Acid
Shogo IWASAKI, Yoshifumi KANEKO, Akiko IKEDA, Makiko YAMAOKA, Sumihisa SUEYOSHI, Hirofumi TANASE, Yoshihiro MASUMOTO
Research Department I, Safety Assessment II, Research Center, Kyorin Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 29-29, 2007.
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P-27 Strain differences in the responsiveness between Sprague-Dawley and Fischer rats to nephropathy induced by FYX-051, a xanthine oxidoreductase inhibitor
Takeo SHIMO1), Naoki ASHIZAWA1), Koji MATSUMOTO1), Kazuhiko OBA1), Takashi NAKAZAWA1), Mitsuyoshi MOTO1), Osamu NAGATA1)
1)Research Laboratories 2, Fuji Yakuhin Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 29-29, 2007.
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P-28 Analysis of gene expression involved in the enhancing effects of chromated copper arsenate (CCA) on skin carcinogenesis
Naofumi TAKAHASHI, Satoru YAMAGUCHI, Ryoichi OHTSUKA, Makio TAKEDA, Yukiko TAKEUCHI, Maki KUWAHARA, Akiko ENOMOTO, Toshiaki KITAZAWA, Nobuaki NAKASHIMA, Takanori HARADA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 20 (suppl) 30-30, 2007.
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P-29 Susceptibility of 4-Nitroquinoline 1-Oxide-induced Tongue Carcinogenesis in CB6F1-Tg-rasH2 Mice
Shingo MIYAMOTO1)2), Yumiko YASUI2), Rikako SUZUKI2), Hiroyuki KOHNO2), Shigeyuki SUGIE2), Takuji TANAKA2)
1)Div. Food Science and Biotech., Graduate School of Agric., Kyoto Univ., 2)Dep. Oncologic Pathol., Kanazawa Med. Univ.
Journal of Toxicologic Pathology 20 (suppl) 30-30, 2007.
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P-30 Susceptibility of p53 knockout mouse to 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ)：Organ-specificity and its implication of p53 gene mutations
Akihiro HIRATA1)2), Tetsuya TSUKAMOTO1), Masami YAMAMOTO1), Shinji TAKASU1)3), Hiroki SAKAI3), Tokuma YANAI3), Toshiaki MASEGI3), Masae TATEMATSU1)
1)Div. Oncol. Pathol., Aichi Cancer Ctr. Res. Inst., 2)Div. Animal Experiment, Life Sci. Res. Ctr., Gifu Univ., 3)Div. Vet. Pathol., Fac. Applied Biol. Sci., Gifu Univ.
Journal of Toxicologic Pathology 20 (suppl) 31-31, 2007.
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P-31 Carcinogenicity of DEN and MelQx in ras H2 mice
Shigeyuki Sugie, Hiroyuki Kohono, Rikako Suzuki, Yumiko Yasui, Shingo Miyamoto, Takuji Tanaka
Department of Pathology, Kanazawa Medical University
Journal of Toxicologic Pathology 20 (suppl) 31-31, 2007.
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P-32 Lung Carcinogenesis Induced by NNK in Ogg1 Knockout Mice
Maki IGARASHI1)2), Midori YOSHIDA3), Manabu WATANABE2), Msayoshi ABE4), Sumio SUGANO2), Dai NAKAE1)5)
1)Lab. Protection of Body Function, Dept. Food and Nutr. Sci., Tokyo Univ. Agricul. Grad. Sch., 2)Lab. Functional Genomics, Grad. Sch. Frontier Sci., Univ. Tokyo, 3)Natl. Inst. of Radiol. Sci., Res. Center Radiation Safety, Low Dose Radiation Effect Project, 4)Biol. Res. Lab., Nissan Chem. Ind., 5)Tokyo Metropolitan Inst. Publ. Health
Journal of Toxicologic Pathology 20 (suppl) 32-32, 2007.
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P-33 Modifying effect of sulfasalazine on colorectal carcinogenesis induced by DMH and DSS
Young-Man CHO, Toshio IMAI, Shigeaki TAKAMI, Masao HIROSE
Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 20 (suppl) 32-32, 2007.
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P-34 Promotion of rat esophageal carcinogenesis by combined treatment with sodium nitrite and ascorbic acid in a reflux esophagitis model.
Yuichi KUROIWA, Yuji ISHII, Keita KANKI, Toshiya OKAMURA, Masako TASAKI, Takashi UMEMURA, Akiyoshi NISHIKAWA, Masao HIROSE
Division of Pathology, NIHS
Journal of Toxicologic Pathology 20 (suppl) 33-33, 2007.
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P-35 Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia for the onset of colorectal carcinogenesis in rats initiated with 1, 2-dimethylhydrazine
Toshio IMAI, Mai HASUMURA, Shigeaki TAKAMI, Young-Man CHO, Masao HIROSE
Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 20 (suppl) 33-33, 2007.
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P-36 Tumor initiation activity of APNH in inflammation-related mouse colonic carcinogenesis
Hiroyuki KOHNO, Yumiko YASUI, Rikako SUZUKI, Shigeyuki SUGIE, Takuji TANAKA
Dept. Oncol. Pathol., Kanazawa Med. Univ.
Journal of Toxicologic Pathology 20 (suppl) 34-34, 2007.
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P-37 Muscular Lesions Induced by Fenofibrate in Rats
Miyoko OKADA, Takako HAMANO, Itsuko IKEDA, Fumiko SANO, Jiro SUGIMOTO, Shiro TAKAGI
Toxicology Laboratory, Mitsubishi Pharma Corporation
Journal of Toxicologic Pathology 20 (suppl) 34-34, 2007.
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P-38 Suppression Effect of Resveratrol on Prostate Carcinogenesis in Transgenic Rat for Adenocarcinoma of Prostate (TRAP) model.
Azman SEENI, Satoru TAKAHASHI, Kumiko OGAWA, Shinya SATO, Tomoyuki SHIRAI
Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci.
Journal of Toxicologic Pathology 20 (suppl) 35-35, 2007.
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P-39 Effects of Bowman-Birk Inhibitor (BBI) on Prostate Carcinogenesis in Transgenic Rats Developing Adenocarcinoma of The Prostate (TRAP)
Ming xi TANG, Makoto ASAMOTO, Kumiko OGAWA, Naomi HOKAIWADO, Shugo SUZUKI, Tomoyuki SHIRAI
Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci.
Journal of Toxicologic Pathology 20 (suppl) 35-35, 2007.
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P-40 Identified genes highly expressed in androgen independent prostate carcinoma cell line.
Naomi HOKAIWADO, Makoto ASAMOTO, Ming xi TANG, Tomoyuki SHIRAI
Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci.
Journal of Toxicologic Pathology 20 (suppl) 36-36, 2007.
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P-41 Possible participation of oxidative DNA damage and its repair enzymes in in vivo mutagenicity in dicyclanil-treated mice
Toshiya OKAMURA1), Takashi UMEMURA1), Keita OKANO1), Yuichi KUROIWA1), Masako TASAKI1), Yukio KODAMA2), Takehiko NHOMI3), Akiyoshi NISHIKAWA1), Masao HIROSE1)
1)Div. of Pathol., 2)Toxicol., 3)Genetics and Mutagenesis., Natl. Inst. Hlth. Sci
Journal of Toxicologic Pathology 20 (suppl) 36-36, 2007.
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P-42 Molecular pathological analysis of β-naphthoflavone-induced tumor promotion in a rat two-stage hepatocarcinogenesis model
Yasuaki DEWA1)2), Jihei NISHIMURA1)2), Masako MUGURUMA1), Meilan JIN1)3), Yukie SAEGUSA1)2), Yusuke KENMOCHI1), Taichi Kono1), Yusuke YOKOUCHI1), Masako TASAKI4), Takashi UMEMURA4), Kunitoshi MITSUMORI1)
1)Lab. Vet. Pathol., Fac. Agri., Tokyo Univ. Agri. and Tech., 2)Pathog. Vet. Sci., Unit. Grad. Sch. Vet. Sci., Gifu Univ., 3)Dept. Appl. Biol. Sci., Unit. Grad. Sch. Agri. Sci., Tokyo Univ. Agri. and Tech., 4)Div. Pathol., Nat. Inst. Health Sci.
Journal of Toxicologic Pathology 20 (suppl) 37-37, 2007.
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P-43 Modifying effects of a combination of MeIQx and α-or β-naphthoflavone on rat liver carcinogenesis.
Kyoko NABAE1), Yuko DOI1)2), Hironao NAKASHIMA1), Toshio ICHIHARA1), Kentaro TAKESHITA2), Makoto ASAMOTO2), Tomoyuki SHIRAI2)
1)DIMS Institute of Medical Science, Inc., 2)Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences.
Journal of Toxicologic Pathology 20 (suppl) 37-37, 2007.
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P-44 Does the initiation activity of NFLX result in the induction of hepatocellular tumors in rats?
Tadashi ITOH1), Mitsuyoshi MOTO1), Yuichi KUROIWA1), Hiroki SAKAI2), Kunitoshi MITSUMORI1)
1)Lab. Vet. Pathol., Fac. Agri., Tokyo Univ. Agri. and Tech., 2)Lab. Vet. Pathol., Gifu Univ.
Journal of Toxicologic Pathology 20 (suppl) 38-38, 2007.
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P-45 In vivo mutagenicity and carcinogenicity of 1, 4-dioxane in gpt delta rat
Masako OMORI1), Min WEI1), Anna KINOSHITA1), Ken-ichi MASUMURA2), Takehiko NOHMI2), Shoji FUKUSHIMA3), Hideki Wanibuchi1)
1)Dept. Pathol., Osaka City Univ. Med. Sch., 2)Div. Genetics and Mutagenesis, NIHS, 3)Japan Bioassay Research Center
Journal of Toxicologic Pathology 20 (suppl) 38-38, 2007.
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P-46 Immunohistochemical analysis of gene expression profiles specific to the tumor promotion processes of rat hepatocarcinogenesis
Miwa TAKAHASHI, Makoto SHIBUTANI, Gye-Hyeong WOO, Kaoru INOUE, Mami U, Hitoshi FUJIMOTO, Masao HIROSE
Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 20 (suppl) 39-39, 2007.
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P-47 Investigation of preneoplastic lesion marker regarding hepatocarcinogenesis in mice
Ayumi KATO1), Anna KINOSHITA1), Wei MIN1), Keiichiro MORIMURA1), Satoru MORI2), Shoji FUKUSHIMA3), Hideki WANIBUCHI1)
1)Osaka City Univ. Med. Sch, Dept. pathol., 2)Sionogi Co., Ltd, 3)Japan Bioassay Research Center.
Journal of Toxicologic Pathology 20 (suppl) 39-39, 2007.
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P-48 Cytokeratin 8/18：a novel marker of rat liver preneoplastic lesions developed into hepatocellular carcinomas
Anna KINOSHITA1), Min WEI1), Keiichirou MORIMURA1), Shyuji HAYASHI1), Shoji FUKUSHIMA2), Hideki WANIBUCHI1)
1)Dept. Pathol., Osaka City Univ. Med. Sch., 2)Japan Bioassay Research Center
Journal of Toxicologic Pathology 20 (suppl) 40-40, 2007.
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P-49 Distribution of Tyrosine Hydroxylase (TH) positive Cells in the Substantia Nigra of Cynomolgus Monkeys
Yohei TANIGAWA, Takeshi KAMENOSONO, Tomonobu YAMADA, Kimiaki HIRAKAWA, Yuki KUWAMURA, Tomohiro FURUKAWA, Kimiyo KAKEHI, Kazuyuki ICHIJO, Hiroaki MAGOTANI, Yasuhiro KAMIMURA, Yutaka CHIHAYA
Shin Nippon Biomedical Laboratories, Ltd.
Journal of Toxicologic Pathology 20 (suppl) 40-40, 2007.
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P-50 A Case Report of Intrathoracic Lymphoma in a Cynomolgus Monkey
Tsuyoshi YOSHIKAWA, Shigeru SATAKE, Rinya KODAMA, Takeshi TOMINAGA, Junko FUJISHIMA, Takaharu KAMIMURA, Yasuhiro KAMIMURA, Yutaka CHIHAYA, Hideyuki YAMATOYA, Hiroshi MAEDA
SHIN NIPPON BIOMEDICAL LABORATORIES, LTD.
Journal of Toxicologic Pathology 20 (suppl) 41-41, 2007.
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P-51 Morphology of the oviducts in Cynomolgus Monkeys during the Menstrual cycle
Hiroko KOKOSHIMA, Yuri KOTANI, Atsushi KUMANO, Takeshi KANNO, Junko SATO, Minoru TSUCHITANI
Mitsubishi Chemical Safety Institute Ltd.
Journal of Toxicologic Pathology 20 (suppl) 41-41, 2007.
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P-52 A case of urinary bladder rhabdomyosarcoma in F344 rat
Hideki SENOH, Yumi UMEDA, Taku KATAGIRI, Shigetoshi AISO, Kasuke NAGANO, Shoji FUKUSHIMA
Japan Bioassay Research Center
Journal of Toxicologic Pathology 20 (suppl) 42-42, 2007.
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P-53 Postoperative desmoid tumors in the Nihon rat, a model for the human Birt-Hogg-Dube syndrome
Mami KOUCHI1), Kazuo OKIMOTO1), Izumi MATSUMOTO1), Yoshiko MICHIMAE1), Tadashi INOUE1), Takaki SEKI1), Masashi YASUBA1), Toru YAMADA2), Toru KIMURA2), Okio HINO3)
1)Safety Research Laboratories, 2)Genomic Science Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3)Department of Molecular Pathogenesis, Juntendo University, School of Medicine
Journal of Toxicologic Pathology 20 (suppl) 42-42, 2007.
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P-54 Spontaneous hepatic arterial lesions in rat
Saki NAITO1), Satoru HOSOKAWA1), Kazuhiro HAYAKAWA1), Akira INOMATA1), Jiro SONODA1), Toyohiko AOKI1), Kazuo TSUKIDATE1)
Drug Safety Research Laboratories, Eisai Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 43-43, 2007.
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P-55 A Comprehensive Review of Non-Epithelial Neoplasms of the Rat Kidney from NTP Studies
John Curtis SEELY1), Gordon C. HARD2)
1)Experimental Pathology Laboratories, Inc., Research Triangle Park, NC, USA, 2)Consultant, National Toxicology Program Archives, Research Triangle Park, NC, USA
Journal of Toxicologic Pathology 20 (suppl) 43-43, 2007.
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P-56 Time-related changes in the incidences of spontaneous neoplasms in F344 rets
Ryo ANDO1), Seiki YAMAKAWA1), Mizuho TAKAGI1), Keita MATSUSHIMA1), Toko OHIRA1), Mariko NAGATANI1), Atsushi NAKAMURA1), Kazutoshi TAMURA1)
1)Bozo research center Inc.
Journal of Toxicologic Pathology 20 (suppl) 44-44, 2007.
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P-57 Effect on osteocompatibility by difference of surface treatment of Ti-Zr alloy
Miki NISHIMORI1), Arisa HOSAKA1), Takeshi NAGAI1), Shin-ichi KATSUDA1), Yoshimitu OKAZAKI2), Emiko GOTO3), Hidetaka SATO1)
1)Japan Food Research Laboratory, 2)National Institute of Advance Industrial Science and Technology, 3)National Institute of Technology and Evaluation
Journal of Toxicologic Pathology 20 (suppl) 44-44, 2007.
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P-58 Study for Formative Mechanism of Multinucleated Hepatocytes Induced by Mitemcinal, an Erythromycin Derivative, in Rats
Shuji HAYASHI1), Etsuko FUJII1), Ayumi FUKUOKA1), Atsuhiko KATO1), Masami SUZUKI1), Tetsuro SUGIMOTO2)
1)Safety Assessment Dept., 2)Regulatory Affairs Audit Dept., Chugai Pharmaceutical Co. LTD.
Journal of Toxicologic Pathology 20 (suppl) 45-45, 2007.
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P-59 Detection of Lung Toxicity Due to Fine Particle Using an Intratracheal Instillation Bioassay in F344 Rats.
Masanao YOKOHIRA, Keiko YAMAKAWA, Kyoko HOSOKAWA, Yoko MATSUDA, Kousuke SAOO, Toshiya KUNO, Katsumi IMAIDA
Oncopathology, Fac. Med., Kagawa Univ.
Journal of Toxicologic Pathology 20 (suppl) 45-45, 2007.
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P-60 Pulmonary Effect of Single-Wall Carbon Nano Tube by Intratracheal Instillation to Rats.
Akira OGAMI, Yasuo MORIMOTO
Dept. of Occupational Pneumology, Inst. Of Industrial Ecological Sciences, Univ. of Occup. And Env. Health, Japan
Journal of Toxicologic Pathology 20 (suppl) 46-46, 2007.
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P-61 Gene expression profiling specific to the target brain regions of developmental hypothyroidism using antithyroid agents via maternal exposure to rats.
Hitoshi FUJIMOTO, Makoto SHIBUTANI, Gye-Hyeong WOO, Kaoru INOUE, Mami U, Miwa TAKAHASHI, Masao HIROSE
Div. Pathol., Natl Inst. Hlth Sci.
Journal of Toxicologic Pathology 20 (suppl) 46-46, 2007.
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P-62 Global DNA methylation analysis in the liver of mice treated with hepatocarcinogens for 28 days. 2nd report.
Mami U1), Makoto SHIBUTANI1), Miwa TAKAHASHI1), Kaoru INOUE1), Gye-Hyeong WOO1), Tomoshi KAKEYA2), Hitoshi FUJIMOTO1), Masao HIROSE1)
1)Div. Pathol., Natl Inst. Hlth Sci., 2)SCRUM Inc.
Journal of Toxicologic Pathology 20 (suppl) 47-47, 2007.
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P-63 Influence of Kupffer cell inactivation on cycloheximide-induced hepatic injury
Kazuyoshi KUMAGAI, Naoki KIYOSAWA, Kazumi ITO, Yosuke ANDO, Toshihiko Makino, Shinobu HAKAMATA, Takashi YAMOTO, Sunao MANABE, Munehiro TERANISHI
Medicinal Safety Research Laboratories, Sankyo Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 47-47, 2007.
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P-64 Application of tissue microarray using new improved assay parameters for liver injuries in preclinical toxicity tests of drugs on experimental animals -The first report-
Masami HASHIZUME1), Shinichiro HASHIURA1), Hiroyuki SHIMIZU1), Yoko SATOH2), Atsushi MITSUMOTO2), Makoto ENOMOTO1)
Hist Science Lab. Co. Ltd.1), Fac. Pharmac. Sci., Josai Internat. Univ.2)
Journal of Toxicologic Pathology 20 (suppl) 48-48, 2007.
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P-65 Pulmonary Lesions in Female Harlan SD Rats Following Two-Year Oral Treatment with Dioxins
Katsuhiko YOSHIZAWA1), Nigel J. WALKER2), Rodney A. MILLER3), Amy E. BRIX3), Donald M. SELLS4), Michael P. JOKINEN5), Michael E. WYDE2), Abraham NYSKA6)
1)Drug Safety Res. Labs., Astellas Pharma Inc., 2)Environmental Toxicology Program, NIEHS, NC, USA, 3)Experimental Pathology Laboratories, Inc., NC, USA, 4)Battelle, Columbus Laboratories, Ohio, USA, 5)Pathology Associates, Inc., A Charles River Company, NC, USA, 6)Toxicologic pathologist, Timrat, Israel.
Journal of Toxicologic Pathology 20 (suppl) 48-48, 2007.
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P-67 Re-evaluation of the Kidney Tumors and Renal Histopathology Occurring in a 2-year Carcinogenicity Bioassay of Quercetin
Shim-mo HAYASHI1), Kazuo YASUHARA2), John C Seely3), Laura Betz4), Gordon C Hard5)
1)San-Ei Gen F.F.I., Inc., Osaka, 2)San-Ei Gen F.F.I., Inc., Tokyo, 3)Experimental Pathology Laboratories Inc., 4)Constella Health Sciences, 5)Private Consultant
Journal of Toxicologic Pathology 20 (suppl) 49-49, 2007.
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P-68 One-year chronic toxicity study of Aloe arborescens Miller var. natalensis Berger in Wistar Hannover rats
Yoko MATSUDA, Masanao YOKOHIRA, Satoshi SUZUKI, Kyoko HOSOKAWA, Keiko YAMAKAWA, Toshiya KUNO, Katsumi IMAIDA
Onco-Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University
Journal of Toxicologic Pathology 20 (suppl) 49-49, 2007.
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P-69 Spermatogenesis of Pubescent and Adult Rats Prenatally Exposure to 3, 3', 4, 4', 5-Pentachlorobiphenyl
Kiyofumi YOKOO1), Shin WAKUI1), Tomoko MUTO2), Yoshikatsu KANAI2), Hitoshi ENDOU2)3)
1)Dept. Toxicol. Pathol, Azabu Univ. Sch. Vet. Med., 2)Dept. Phrmacol, Kyorin Univ. Sch. Med., 3)Fuji Biomedix.
Journal of Toxicologic Pathology 20 (suppl) 50-50, 2007.
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P-70 Hypothermia-related Testicular Toxicity of Reserpine in Mice
Makoto SATO, Meiko FUKUDA, Takanori MINAMI, Keisuke KITAURA, Satoshi MATSUMOTO
Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 50-50, 2007.
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P-71 Busulfan-induced apoptosis in rat placenta
Satoshi FURUKAWA, Koji USUDA, Masayoshi ABE, Seigo HAYASHI, Izumi OGAWA
Biological Research Laboratories, Nissan Chemical Industries, Ltd.
Journal of Toxicologic Pathology 20 (suppl) 51-51, 2007.
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P-72 Histopathological characteristics in hepatocellular nodules found in the long-term bioassay for tocotrienol
Masako TASAKI1), Yuichi KUROIWA1), Toshiya OKAMURA1), Takashi UMEMURA1), Akiyoshi NISHIKAWA1), Masao HIROSE1)
1)Div. of Path., NIHS
Journal of Toxicologic Pathology 20 (suppl) 51-51, 2007.
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P-73 Experimental model for idiopathic interstitial pneumonia by intratracheal administration of fluorescein isothiocyanate and bleomycin in rats
Akika SAKAMOTO1), Kazutoshi TAMURA2), Masayuki MITSUI3), Kazumi SHIRAIWA2), Tsukasa KITAHASHI4), Masahiro TSUTSUMI5)
1)Kyoto Prefectural University, 2)Bozo Research Center, 3)Nara Medical University, 4)National Cancer Center Research Institute, 5)Saiseikai Chuwa Hospital
Journal of Toxicologic Pathology 20 (suppl) 52-52, 2007.
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P-74 Effects of insulin on proliferative changes of forestomach mucosa in alloxan-induced diabetic rats.
Tomoya SANO1), Kiyokazu OZAKI1), Yasushi KODAMA2), Tetsuro MATSUURA1), Isao NARAMA1)
1)Dept. of Pathol., Fac. Pharm., Setsunan Univ., 2)Fac. Pharm., Hiroshima International Univ.
Journal of Toxicologic Pathology 20 (suppl) 52-52, 2007.
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P-75 No promoting effect of Isoleucine and Leucine in rat bladder carcinogenesis
Takayuki YUNOKI1), Wei MIN1), Anna KINOSHITA1), Kenichirou Doi1), Masako OMORI1), Shoji FUKUSHIMA2), Hideki WANIBUCHI1)
1)Department of Pathology Osaka City Univ. Med. School, 2)Japan Bioassay Research Center
Journal of Toxicologic Pathology 20 (suppl) 53-53, 2007.
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P-76 Absence of promotion of MeIQx-induced rat colon carcinogenesis by ethanol
Masahiko KUSHIDA1), Min WEI1), Anna Kinoshita1), Keisuke Ozaki1), Tokuo Sukata1), Satoshi Uwagawa1), Shoji FUKUSHIMA3), Hideki WANIBUCHI1)
1)Pathology and Clinical Science Group, Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 2)Department of Pathology, Osaka City University Medical School, 3)Japan Bioassay Research Center, Japan Industrial Safety and Health Association
Journal of Toxicologic Pathology 20 (suppl) 53-53, 2007.
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P-77 Suppressive effects of 4-viny1-2, 6-dimethoxyphenol (Canolol) on Helicobacter pylori infection and glandular stomach carcinogenesis in gerbils
Takeshi TOYODA1), Tetsuya TSUKAMOTO1), Xueyuan CAO1), Takahiro SEKI2), Shigeru MORIMURA2), Hiroshi MAEDA3), Masae TATEMATSU1)
1)Div. Oncol. Pathol., Aichi Cancer Center Res. Inst., 2)Kumamoto Univ., Graduate School Sci. and Technol., 3)Sojo Univ., Facul. Pharmaceut. Sci.
Journal of Toxicologic Pathology 20 (suppl) 54-54, 2007.
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P-78 Expression of inflammation-related factors by high salt diet in the gastric mucosa of Helicobacter pylori- infected Mongolian gerbils
Masami YAMAMOTO, Tetsuya TSUKAMOTO, Takeshi TOYODA, Shinji TAKASU, Naoki HIRANO, Masae TATEMATSU
Div. Oncol. Pathol., Aichi Cancer Ctr. Res.
Journal of Toxicologic Pathology 20 (suppl) 54-54, 2007.
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P-79 Investigation of initiation activity of 4-oxo-2-hexenal with in vivo 5-week initiation assay
Shinji TAKASU1)2), Tetsuya TSUKAMOTO1), Akihiro HIRATA1)2), Takeshi TOYODA1), Kazuaki KAWAI3), Hiroki SAKAI2), Masami YAMAMOTO1), Tokuma YANAI2), Toshiaki MASEGI2), Hiroshi KASAI3), Masae Tatematsu1)
1)Div. Oncol. Patho., Aichi Cancer Center Res. Instit., 2)Dep. Vet. Patho., Fac. Agri., Gifu Univ., 3)Dep. Envoi. Oncol., Insti. of Industrial Ecological Sci., Univ of Occupational and Enviro Health
Journal of Toxicologic Pathology 20 (suppl) 55-55, 2007.
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P-80 Nasal Tumors in Rats Exposed to n-Butyl Glycidyl Ether for Two Years
Yumi UMEDA, Hideki SENOH, Taku KATAGIRI, Shigetoshi AISO, Kasuke NAGANO, Shoji FUKUSHIMA
Japan Bioassay Research Center
Journal of Toxicologic Pathology 20 (suppl) 55-55, 2007.
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P-81 Examination of carcinogenesis in rat lung by intratracheal administration of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Osamu KUSUOKA1), Masayuki MITSUI2), Akika SAKAMOTO3), Ami AOKI1), Kazutoshi TAMURA1), Toshifumi TSUJIUCHI4), Yoichi KONISHI5), Masahiro TSUTSUMI6)
1)Bozo Research Center Inc., 2)Nara Med. Univ., 3)Kyoto Prefectural Univ., 4)Kinki Univ., 5)LF.S.T.P., 6)Saiseikai Chuwa Hosp.
Journal of Toxicologic Pathology 20 (suppl) 56-56, 2007.
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P-82 Effects of Neonatally Administered DES on Induction of Mammary Masses Induced by DMBA in Rats
Hiroaki KAWAGCHI1), Masakazu SOUDA1), Tsuyoshi YOSHIKAWA1)2), Emiko HARUYAMA1)2), Yoshihisa UMEKITA1), Hiroki YOSHIDA1)
1)The Department of Tumor Pathology, Kagoshima University, Graduate School of Medical and Dental Sciences, 2)Shin Nippon Biochemical Laboratories, Ltd.
Journal of Toxicologic Pathology 20 (suppl) 56-56, 2007.
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P-83 Stereological analysis of inflamed thyroid capsular lesions and invasive follicular cell carcinomas in DHPN-SDM-treated rats
Shigeaki TAKAMI, Toshio IMAI, Mai HASUMURA, Young-Man CHO, Masao HIROSE
Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 20 (suppl) 57-57, 2007.
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P-84 Modifying Effects of Crassocephalum crepidioides on Azoxymethane-Induced Colon Carcinogenesis in Male F344 Rats
Takamitsu MORIOKA, Junya ARAKAKI, Nao SUNAGAWA, Itaru TIBA, Nanae MORITA, Naoki YOSHIMI
Tumor Patholory, University of the Ryukyus Faculty of Medicine
Journal of Toxicologic Pathology 20 (suppl) 57-57, 2007.
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P-85 Change and Role of Hepatocyte Growth Factor (HGF) on Hepatocellular Proliferation Induced by Peroxisome Proliferator-Activated Receptor-alpha (PPAR α) Agonist
Makiko YAMAOKA, Sumihisa SUEYOSHI, Syougo IWASAKI, Yoshihiro MASUMOTO, Takashi TSUNODA, Takahiro TANASE, Tomomi KOIKE
Research Center, Kyorin Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 20 (suppl) 58-58, 2007.
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P-86 Mechanistic study on fenofibrate-induced hepatocarcinogenesis in a 2-stage hepatocarcinogenesis model of rats：Involvement of oxidative stress
Jihei NISHIMURA1)2), Yasuaki DEWA1)2), Masako MUGURUMA1), Meilan JIN1)3), Yusuke KENMOCHI1), Taichi KONO1), Yusuke YOKOUCHI1), Masako TASAKI4), Takashi UMEMURA4), Kunitoshi MITSUMORI1)
1)Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2)Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 3)Biochemistry and Biotechnology, United Graduate School of Agricultural Sciences, Tokyo University of Agriculture and Technology, 4)Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 20 (suppl) 58-58, 2007.
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P-87 Reactive Oxygen Species are Possibly Involved in the Mechanism of Flumequine-Induced Hepatocarcinogenesis in Mice
Yusuke KENMOCHI1), Miwa TAKAHASHI2), Mitsuyoshi MOTO3), Masako MUGURMA1), Jihei NISHIMURA1)4), Meilan JIN1)5), Taichi KONO1), Yusuke YOKOUCHI1), Kunitoshi MITSUMORI1)
1)Lab. Vet. Pathol., Fac. Agri., Tokyo Univ. Agri. and Tech., 2)Div. Pathol., Nat. Inst. Health Sci., 3)Research Lab.2. Fujiyakuhin., 4)Pathog. Vet. Sci., Unit. Grad. Sch. Vet. Sci., Gifu Univ., 5)Dept. Appl. Biol. Sci., Unit. Grad. Sch. Agri. Sci., Tokyo Univ. Agri. and Tech.
Journal of Toxicologic Pathology 20 (suppl) 59-59, 2007.
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P-88 Effects of 1-nitropropane and 2-nitropropane on Hepatocarcinogenesis in a Rat Medium-Term Liver Bioassay
Yuko DOI1), Norio IMAI1), Akihiro HAGIWARA1), Mayumi KAWABE1), Fumio FURUKAWA1), Masanori OTSUKA2)
1)DIMS Institute of Medical Science, Inc., 2)Chemicals Evaluation and Research Institute
Journal of Toxicologic Pathology 20 (suppl) 59-59, 2007.
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P-89 No Induction of Preneoplastic Lesions, Glutathione S-Transferase Placental Positive Foci in the Liver at Low-doses, But Induction of Hepatocellular Carcinomas at High Dose in F344/DuCrj Rats Treated with 2-Amino-3, 8-dimethylimidazo-[4, 5-f]quinoxaline
Takashi MURAI1), Satoru MORI2), Jin Seok KANG2), Keiichirou MORIMURA2), Hideki WANIBUCHI2), Yukari TOTSUKA3), Shoji FUKUSHIMA4)
1)Developmental Research Laboratories Shionogi & Co., Ltd., 2)First Department of Pathology Osaka City University Medical School, 3)Cancer Prevention Basic Research Project, National Cancer Center Research Institute, 4)Japan Bioassay Research Center, Japan Industrial Safety and Health Association
Journal of Toxicologic Pathology 20 (suppl) 60-60, 2007.
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P-90 Promoting Effects of Diphenylarsinic Acid in Rat Hepatocarcinogenesis
Min WEI1), Anna KINOSHITA1), Mitsuaki KITANO2), Kenichiro Doi1), Takayuki YUNOKI1), Shoji FUKUSHIMA3), Hideki WANIBUCHI1)
1)Dep. of Pathol., Osaka City Univ. Med. Sch., 2)Life Science RD Center, Kaneka Corp., 3)Japan Bioassay Research Center
Journal of Toxicologic Pathology 20 (suppl) 60-60, 2007.
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P-91 Evaluation of Carcinogenic Risks of Catechins and Copper Gluconate in a Medium-term Rat Liver Bioassay.
Masayoshi Abe1), Koji Usuda1), Satoshi Furukawa1), Lekh Rej Juneja2), Tsutomu Okubo2), Dai Nakae3)4)
1)Bio. Res. Lab., Nissan Chem. Ltd., 2)Taiyo Kagaku Co., Ltd., 3)Tokyo Metropolitan Institute of Public Health, 4)Tokyo University of Agriculture
Journal of Toxicologic Pathology 20 (suppl) 61-61, 2007.
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