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Journal of Toxicologic Pathology 23巻 suppl号

発行元
日本毒性病理学会
ISSN
0914-9198
ISSN（オンライン）
1881-915X
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開始頁
T-1 Development of Genotoxicity Assays with Transgenic Rodents
Takehiko Nohmi
Nat'l Inst Health Sci
Journal of Toxicologic Pathology 23 (suppl) 1-1, 2010.
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T-2 Role of Epigenetic Modifications in Multistage Tumorigenesis of The Colon
Yasuhiro YAMADA
Center for iPS Cell Research and Application (CiRA), Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
Journal of Toxicologic Pathology 23 (suppl) 1-1, 2010.
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S1-1 Chemoprevention Research for Prostate Cancer using TRAP Rats
Satoru TAKAHASHI1), 2), Makoto ASAMOTO1), Tomoyuki SHIRAI1)
1)Dept Exp Pathol Tumor Biol, Nagoya City Univ Grad Sch Med Sci, 2)Div Pathol, Nagoya City Univ Hosp.
Journal of Toxicologic Pathology 23 (suppl) 2-2, 2010.
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S1-2 Colon Carcinogenesis Study with A Novel Apc-mutant Rat
Takashi KURAMOTO
Inst Lab Anim, Grad Sch Med Kyoto Univ
Journal of Toxicologic Pathology 23 (suppl) 2-2, 2010.
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S1-3 Inflammation and Cancer： Lessons from Pathway Specific Model Mice
Masanobu OSHIMA1)
1)Cancer Res Inst, Kanazawa Univ
Journal of Toxicologic Pathology 23 (suppl) 3-3, 2010.
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S1-4 Promising Applicability of Reporter Gene Transgenic Rodents in Cancer Research
Takashi UMEMURA
Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 23 (suppl) 3-3, 2010.
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S1-5 Cytogenesis of Pancreatic Ductal Adenocarcinoma in the Rat
Katsumi FUKAMACHI1), Hajime TANAKA2), Mitsuru FUTAKUCHI1), Hiroyuki TSUDA3)
1)Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 2)Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 3)Nanotoxicology Project, Nagoya City University Graduate School of Medical Sciences
Journal of Toxicologic Pathology 23 (suppl) 4-4, 2010.
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S2-1 Pathogenesis of renal interstitial fibrosis, based on the relationship between macrophages and myofibroblasts
Jyoji YAMATE1), Ryo YANO1), Fumi MURAI1), Emi YAMAMOTO1), Takahiro YUASA1), Masanori KURIBAYASHI1), Mitsuru KUWAMURA1)

Journal of Toxicologic Pathology 23 (suppl) 4-4, 2010.
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S2-2 Pathological features of kidney and peripheral nerve lesions in spontaneous and drug-induced diabetic rats.
Kiyokazu OZAKI, Tomaya SANO, Mai SATO, Chinami KIKKAWA, Tetsuro MATSUURA, Isao NARAMA
Department of Pathology, Faculty of Pharmaceutical Science, Setsunan University
Journal of Toxicologic Pathology 23 (suppl) 5-5, 2010.
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S2-3 Histopathological Features of Diabetic Ocular Complications in the Spontaneously Diabetic Torii (SDT) Rat
Toshiyuki SHODA1), Masami SHINOHARA2)
1)Toxicology Research Laboratories, Central Pharmaceutical Institute, JAPAN TOBACCO Inc., 2)Planning and Development Section, CLEA Japan, Inc.
Journal of Toxicologic Pathology 23 (suppl) 5-5, 2010.
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S2-4 Development of Hepatitis, Hepatic Fibrosis and Hepatic Tumor in Diet-induced Non-alcoholic Steatohepatitis Model Rats
Takahisa NOTO
Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc.
Journal of Toxicologic Pathology 23 (suppl) 6-6, 2010.
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S2-5 Pathogenesis of Pulmonary Fibrosis Following Intratracheal Instillation of DDAC in Mice
Toshinori Yoshida, Aya Ohnuma, Takanori Harada
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 23 (suppl) 6-6, 2010.
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O-1 Mechanism of Rat Lung Carcinogenesis Promotion by Inhalation Exposure of C60 and MWCNT
Mitsuru FUTAKUCHI1), Katsumi FUKAMACHI1), Jiegou XU1), Hiroyuki TSUDA1), 2)
1)Dept. of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 2)Nano Toxicology project, Nagoya City University Graduate School of Medical Sciences
Journal of Toxicologic Pathology 23 (suppl) 7-7, 2010.
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O-2 Pulmonary effect of MWCNT by intratracheal instillation to rats.
Akira OGAMI1), Yasuo MORIMOTO1)
1)Inst. of Ind. Ecol. Sci., Univ. of Occup. & Envirn. Health
Journal of Toxicologic Pathology 23 (suppl) 7-7, 2010.
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O-3 Serum N-ERC/mesothelin Level of Untreated Rats with Different Strains Sexes and Ages.
Yoshimitsu SAKAMOTO1), Dai NAKAE1), 2), Kuniaki TAYAMA1), Kanako SATOH1), Yoshiaki HAGIWARA3), 4), Okio HINO4), Norio OHASHI1), Akio OGATA1)
1)Tokyo Metr Inst Pub Health, 2)Tokyo University of Agriculture, 3)Immuno-Biol. Lab. Co.,Led,., 4)Dep. of Pathology and Oncology, Juntendo Univercity, School of Medicine
Journal of Toxicologic Pathology 23 (suppl) 8-8, 2010.
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O-4 Effects of diacylglycerol on PKC expression in Hras128 rat mammary carcinogenesis
Masumi SUZUI1), Ichiro YOSHIDA1), Toshiyuki MATSUNAGA2), Akira HARA2), Yutaka ITABASHI3), Takeji TAKAMURA4), Masaaki IIGO5), Katsumi FUKAMACHI5), Hiroyuki TSUDA5)
1)Dept. of Medical Therapeutics and Molecular Therapeutics, Gifu Pharm. Univ., 2)Dept. of Biochemistry, Gifu Pharm. Univ., 3)Dept. of Marine Bioresource Chemistry, Hokkaido Univ., 4)Dept. of Applied Chemistry, Kanagawa Inst. of Technology, 5)Dept. of Molecular Toxicology, Graduate School of Medical Sciences, Nagoya City Univ.
Journal of Toxicologic Pathology 23 (suppl) 8-8, 2010.
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O-5 Analysis of the Mechanisms of Chemical-inducible Liver Hypretrophy in CAR Deficient Mice.
Yohei SAKAMOTO1), Midori YOSHIDA1), Kaoru INOUE1), Miwa TAKAHASHI1), Syogo OZAWA2), Masahiko NEGISHI3), Akiyoshi NISHIKAWA1)
1)Div. Pathol., NIHS, 2)Dept. Pharmacodynamics Mol. Genetics, Sch. Pharmacy, Iwate Med. Univ., 3)Lab. Reprod. Dev. Tox.., NIEHS/NIH
Journal of Toxicologic Pathology 23 (suppl) 9-9, 2010.
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O-6 Estrogen and androgen signaling in hepatocellular hypertrophy in rats
Nariaki FUJIMOTO1), Midori YOSHIDA2), Akiyoshi NISHIKAWA2), Shogo OZAWA3), Toshie GAMO3), Kiyomitsu NEMOTO4), Masakuni DEGAWA4)
1)RIRBM, Hiroshima Univ, 2)Div. Pathology, NIHS, 3)Sc. Pharmacy, Iwate Med. Univ., 4)Sc. Pharm. Sci., Univ Shizuoka.
Journal of Toxicologic Pathology 23 (suppl) 9-9, 2010.
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O-7 Microangiopathy Associated with MNU-induced Retinal Degeneration in Mice
Akihiro NAKATANI, Tetsuro MATSUURA, Kiyokazu OZAKI, Isao NARAMA
Faculty of Pharmaceutical Sciences, Setsunan University
Journal of Toxicologic Pathology 23 (suppl) 10-10, 2010.
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O-8 Modifying Effects of Type 2 Diabetes Mellitus in Rat Carcinogenesis
Naomi ISHII, Min WEI, Anna KAKEHASHI, Shotaro YAMANO, Shinya NAKATANI, Hideki WANIBUCHI
Dept. Path., Osaka City Univ. Grad. Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 10-10, 2010.
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O-9 Disruption of Smad-dependent Signaling for Growth of GST-P-positive Lesions from the Early Stage in a Rat Two-stage Hepatocarcinogenesis Model
Makoto SHIBUTANI1), Ryohei ICHIMURA1), Eriko TANIAI1), Miwa TAKAHASHI2), Sayaka KEMMOCHI1), 3), Kunitoshi MITSUMORI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agri. Tech., 2)Div. Pathol., Nat. Inst. Health Sci., 3)United Grad. Sch. Vet. Sci., Gifu Univ.
Journal of Toxicologic Pathology 23 (suppl) 11-11, 2010.
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O-10 Carcinogenic Potential and Formation of Specific DNA Adducts of Estragole in the Rat Liver
Yuta Suzuki, Aki Kijima, Daisuke Hibi, Meilan Jin, Yuji Ishii, Takashi Umemura, Akiyoshi Nishikawa
Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 23 (suppl) 11-11, 2010.
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O-11 Toxicological evaluation of furan using a newly developed short-term comprehensive method with gpt delta rats
Daisuke HIBI1), Aki KIJIMA1), Yuta SUZUKI1), Jin MEILAN1), Yuji ISHII1), Norio MASUI3), Takehiko NOHMI2), Takashi UMEMURA1), Akiyoshi NISHIKAWA1)
1)Divisions of Pathology, National Institute of Health Sciences, 2)Divisions of Genetics and Mutagenesis, National Institute of Health Sciences, 3)Japan SLC, Inc.
Journal of Toxicologic Pathology 23 (suppl) 12-12, 2010.
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O-12 Mechanism of Promotion Effect of Diphenylarsenic Acid on Rat Liver Carcinogenesis
Takanori YAMADA, Min WEI, Naoto SUGA, Akihiro KANAGAWA, Anna KAKEHASHI, Hideki WANIBUCHI
Department of Pathology, Osaka City University Medical School
Journal of Toxicologic Pathology 23 (suppl) 12-12, 2010.
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O-13 Suppressive Effect of Global DNA Hypomethylation on Gastric Carcinogenesis： Analysis by Dnmt1 Hypomorphic Mouse
Akihiro HIRATA1), Yasuhiro YAMADA2), Hiroyuki Tomita3), Satoshi YAMASHITA4), Toshikazu USHIJIMA4), Akira HARA3)
1)Div. Animal Experiment, Life Sci. Res. Ctr., Gifu Univ., 2)Ctr. for iPS Cell Res. and Application(CiRA), Inst. for Integrated Cell-Material Sci., Kyoto Univ., 3)Dept. Tumor Pathol., Gifu Univ. Graduate Sch. of Med., 3)Div. Carcinogenesis, Natl. Cancer Ctr. Res. Inst.
Journal of Toxicologic Pathology 23 (suppl) 13-13, 2010.
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O-14 A Review for Histopathological Changes Induced by an Oncolytic Adenovirus (Telomelysin, OBP-301) in Preclinical and Clinical Studies
Aisuke NII1), Shiou-Hwei YEH2), Pei-Jer CHEN2), John NEMUNAITIS3), Toshiyoshi FUJIWARA1), 4), Yasuo URATA1)
1)Oncolys BioPharma, 2)Taiwan University Hospital, 3)Mary Crowly Cancer Research Centers, 4)Center for Gene and Cell Therapy, Okayama University Hospital
Journal of Toxicologic Pathology 23 (suppl) 13-13, 2010.
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O-15 Increase of GABAergic Interneurons in the Hippocampal Dentate Gyrus by Developmental Exposure to Acrylamide
Bunichiro OGAWA1), Yukie SAEGUSA1), 2), Takumi OHISHI1), LIyun WANG1), Miwa TAKAHASHI3), Jun NAKAHIGASHI4), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agri. and Tech., 2)United Grad. Sch. Vet. Sci., Gifu Univ., 3)Div. Pathol., Nat. Inst. Health Sci., 4)Chitose Lab., Jpn. Food Res. Lab.
Journal of Toxicologic Pathology 23 (suppl) 14-14, 2010.
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O-16 Establishment of a new invasive urinary bladder cancer model using human c-Ha-ras proto-oncogene transgenic rats
Yumi OBO1), Min WEI1), Syotsro YAMANO1), Mitsuaki KITANO1), Manabu HOSHI1), Hideki WANIBUCHI1)
1)1st Dept. Pathol., Osaka City Univ., Grad., Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 14-14, 2010.
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O-17 Establishment of an animal model by allogeanic and orthotopic transplantation of a rat prostate cancer cell line
Takuya OYABU1), Ne LONG1), Shinya SATO1), Taku NAIKI1), Satoru TAKAHASHI1), Tomoyuki SHIRAI1)
1)Dept. of Exp. pathol. and Tumor Biol., Nagoya City Univ.
Journal of Toxicologic Pathology 23 (suppl) 15-15, 2010.
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P-1 Isolated glomerular proteome analysis of rats with the non-insulin-dependent diabetes mellitus
Nakatani SHINYA, Naomi ISHII, Shotaro YAMANO, Anna KAKEHASHI, Min WEI, Hideki WANIBUCHI
Dept. Path., Osaka City Univ. Grad. Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 15-15, 2010.
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P-2 Histopathological Analysis of Diabetic Nephropathy in Spontaneously Diabetic Torii (SDT) Rats, Type 2 Diabetes
Emiko KUWASAKI1), Mikio MITSUISHI1), Koshirou KATOKU1), Takafumi OSHIKATA1), Yutaka NAKAHARA1), Shino KUMABE1), Masao HAMAMURA1)
1)Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 23 (suppl) 16-16, 2010.
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P-3 Carcinogenic mechanism of squamous cell carcinoma in the forestomach of Alloxan-induced Diabetic Rats.
Tomoya SANO1), Kiyokazu OZAKI1), Yasushi KODAMA2), Tetsuro MATSUURA1), Isao NARAMA1)
1)Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 2)Faculty of Pharmaceutical Sciences, Hiroshima International University
Journal of Toxicologic Pathology 23 (suppl) 16-16, 2010.
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P-4 High susceptibility to azoxymethane-induced ear duct and intestinal carcinogenesis in OLETF rats
Ezar HAFEZ, Tetsuyuki TAKAHASHI, Keisuke IZUMI
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, the University of Tokushima Graduate School
Journal of Toxicologic Pathology 23 (suppl) 17-17, 2010.
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P-5 N-Methyl-N-Nitrosourea-Induced Retinal Degeneration in Mouse Is Independent of p53 Gene
Katsuhiko Yoshizawa, Maki Kuwata, Clark Lai, Sayaka Kanematsu, Hisanori Miki, Ayako Kawanaka, Norihisa Uehara, Takashi Yuri, Airo Tsubura
Pathology II, Kansai Medical University
Journal of Toxicologic Pathology 23 (suppl) 17-17, 2010.
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P-6 Triparanol-induced Cataract in the Rat-Morphological and Molecular Analyses-
Yuki MOMOZAWA1), Naoki TORITSUKA2), Taro HIHARA2), Yuko NAGAYAMA1), Aya MORITO1), Etsuko OTA1), Kyoko NAKANO1), Akira INOMATA1), Akiyoshi SUGANUMA1), Toyohiko AOKI1), Kazuo TSUKIDATE1)
1)Tsukuba, Drug Safety Japan, Global Drug Safety, 2)Applied Pharmacology & New Technologies, Biopharmaceutical Assessments Core Function Unit, Eisai Product Creation Systems, Eisai Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 18-18, 2010.
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P-7 Microvascular Architecture of the Eye of Aging Royal College of Surgeons (RCS) Rat： A Scanning Electron Microscopic Study of Vascular Corrosion Casts
Miwa YOSHIMI1), Osamu KATSUTA1), Chinami KIKKAWA1), Isao NARAMA2)
1)Santen Pharmaceutical Co.,Ltd., 2)Setsunan Univ.
Journal of Toxicologic Pathology 23 (suppl) 18-18, 2010.
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P-8 Retinal Lesion in the hhy Hydrocephalus Mutant Mouse
Mitsuru KUWAMURA1), Tomoko OGATA, Jyoji YAMATE, Nobuko MORI
1)Laboratory of Veterinary Pathology, Osaka Prefecture Univeristy, 2)Medical Genetics Laboratory, Osaka Prefecture University
Journal of Toxicologic Pathology 23 (suppl) 19-19, 2010.
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P-9 Inhibitory Effects of Bitter Melon Leaf Extract on Prostate Cancer Cell Migration and Invasion
Pornsiri Pitchakarn1), 3), Kumiko Ogawa1), 2), Shugo Suzuki1), Satoru Takahashi1), Makoto Asamoto1), Pornngarm Limtrakul3), Tomoyuki Shirai1)
1)Dept. of Exp. Pathol. & Tumor Biol., Nagoya City Univ., 2)Div. Pathol, NIHS., 3)Dept. of Biochem., Med., Chiang Mai Univ.
Journal of Toxicologic Pathology 23 (suppl) 19-19, 2010.
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P-10 Relationship of heat shock protein 25 with reactive macrophages in thioacetamide-induced rat liver injury
Kae FUJISAWA1), Noriko TSUCHIYA1), Koichi MASUNO1), Emi YAMAMOTO1), Toshiyuki MARUYAMA1), Mitsuru KUWAMURA2), Jyoji YAMATE2), Mikinori TORII1)
1)Shionogi & Co.,Ltd., 2)Osaka Prefecture Univ.
Journal of Toxicologic Pathology 23 (suppl) 20-20, 2010.
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P-11 Decrease of Liver Tumor Formation in CYP2E1-null Mice Treated With Diethylnitrosamine
Jin Seok KANG1), Hideki WANIBUCHI2), Shoji FUKUSHIMA3)
1)Department of Biomedical Laboratory Science, Namseoul University, 2)Department of Pathology, Osaka City University Medical School, 3)Japan Bioassay Research Center
Journal of Toxicologic Pathology 23 (suppl) 20-20, 2010.
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P-12 The Metabolic Relationship of CYP1A2 Expression to MeIQx-induced Rat Hepatocarcinogenesis
Shugo SUZUKI1), 3), Kentaro TAKESHITA1), Yuko DOI2), Makoto ASAMOTO1), Satoru TAKAHASHI1), Tomoyuki SHIRAI1)
1)Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci., 2)DIMS Institute of Medical Science, Inc., 3)Pathology Division, East Medical Center Higashi Municipal Hospital City of Nagoya
Journal of Toxicologic Pathology 23 (suppl) 21-21, 2010.
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P-13 Aging effects on susceptibility to chemical hepatocarcinogenesis in Cx32 dominant negative transgenic rats
Aya NAIKI-ITO1), Makoto ASAMOTO1), Shinya SATO1), Shugo SUZUKI1), Tomoyuki SHIRAI1)
1)Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci.
Journal of Toxicologic Pathology 23 (suppl) 21-21, 2010.
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P-14 Oxidative DNA Damage and In vivo Mutagenicity in the Livers of gpt delta Rats Given Non-genotoxic Hepatocarcinogens with CYP-inducible Potency
Masako TASAKI1), Tomoki INOUE1), Toshiya OKAMURA1), Yuji ISHII1), Norio MASUI3), Takehiko NOHMI2), Takashi UMEMURA1), Akiyoshi NISHIKAWA1)
1)Divisions of Pathology, National Institute of Health Sciences, 2)Divisions of Genetics and Mutagenesis, National Institute of Health Sciences, 3)Japan SLC, Inc.
Journal of Toxicologic Pathology 23 (suppl) 22-22, 2010.
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P-15 Analysis of Metabolic Pathway of Dimethylarsinic Acid in Rats
Akihiro KANAGAWA1), 2), Naoto SUGA1), Kaoru YOSHIDA1), Ginji ENDO2), Satoru MORI1), Min WEI1), Hideki WANIBUCHI1)
1)Dept. Pathol., 2)Department of Preventive Medicine and Environmental Health Osaka City Univ. Grad., Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 22-22, 2010.
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P-16 Effects of CCl4-induced Hepatic Injury on in vivo Mutagenicity of MeIQx in the Livers of p53-proficient or-deficient gpt delta Mice
Toshiya OKAMURA1), Yuji ISHII1), Tomoki INOUE1), Masako TASAKI1), Yuta SUZUKI1), Yukio KODAMA2), Takehiko NOHMI3), Takashi UMEMURA1), Akiyoshi NISHIKAWA1)
1)Div. Pathol., 2)Animal Care Section, 3)Div. Genet. & Mutagen., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 23 (suppl) 23-23, 2010.
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P-17 Identification of prostate cancer stem cells in the bone microenvironment.
Shinya SATO, Aya NAIKI, Satoru TAKAHASHI, Makoto ASAMOTO, Taku NAIKI, Tomoyuki SHIRAI
Dept. of Exp. Pathol. And Tumor Biol., Nagoya City Univ.
Journal of Toxicologic Pathology 23 (suppl) 23-23, 2010.
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P-18 Uterine masses of the rabbit uterus-abdominal wall adhesion model
Satomi HARANO1), Sumika MIYABASHIRA2), Yuki ISHIZAWA1), Noriko SHINYA1), Mika KIYOKAWA1), Miho FUJIMOTO1), Hajime MATSUI1), Takamichi SHIGAKI1)
1)The Chemo-Sero-Terapeutic Research Institute Pathological department, 2)The Chemo-Sero-Terapuetic Research Institute Therapeutic Protein Products Research Department
Journal of Toxicologic Pathology 23 (suppl) 24-24, 2010.
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P-19 Morphological Image Analyses to Assess the Effect of Telmisartan on Bleomycin-induced Lung Fibrosis in Mice.
Naoaki YAMADA1), Hiroko KOKOSHIMA1), Takeshi KANNO1), Minoru TSUCHITANI1)
1)Pathology department, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 23 (suppl) 24-24, 2010.
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P-20 The proteome analysis of mice lung tumors by QSTAR Elite LC-MS/MS
Shotaro YAMANO, Anna KAKEHASHI, Yoshiyuki TAGO, Takanori Yamada, Keikou Tei, Min WEI, Hideki WANIBUCHI
Department of Pathology, Osaka City University Medical School
Journal of Toxicologic Pathology 23 (suppl) 25-25, 2010.
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P-21 Chemopreventive Effects of PJJ-34 on Mice Lung Squamous Cell Carcinoma
Yoshiyuki TAGO1), Takanori YAMADA1), Shotaro YAMANO1), Mitsuaki KITANO1), Hideki WANIBUCHI1)
1)Dept. Pathol, Osaka City Univ. Med. Sch
Journal of Toxicologic Pathology 23 (suppl) 25-25, 2010.
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P-22 Morphological characteristics of the carcinogen-induced thyroid proliferative lesions in BrIHan：WIST@Jcl (GALAS) rats with vacuolar change/hydropic degeneration of thyroid follicular cells
Masayoshi Abe1), Seigo Hayashi1), Koji Usuda1), Satoshi Furukawa1), Dai Nakae2), 3)
1)Bio. Res. Lab., Nissan Chem Ltd., 2)Tokyo Metropolitan Institute of Public Health, 3)Tokyo University of Agriculture
Journal of Toxicologic Pathology 23 (suppl) 26-26, 2010.
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P-23 Development of a Short Term Two-stage Skin Carcinogenicity Model Using rasH2 Mice
Mayuko SUGURO1, Takamasa NUMANO1, Mayumi KAWABE1, Fumio FURUKAWA1, Kouji URANO2, Hideki TSUTSUMI2
1DIMS Institute of Medical Science, Inc., 2Central Institute for Experimental Animals
Journal of Toxicologic Pathology 23 (suppl) 26-26, 2010.
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P-24 A 3-Month Oral Dose Toxicity Study of Acrylamide in Syrian Hamsters
Toshio IMAI1), Satomi KOHNO1), Takuya HAYAKAWA2), Tsukasa KITAHASHI1)
1)Central Animal Lab., 2)Cancer Prevention Basic Res. Project, Natl. Cancer Center Res. Institute
Journal of Toxicologic Pathology 23 (suppl) 27-27, 2010.
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P-25 Promoting Effects of Sugar-rich Diet on N-nitrosobis (2-oxopropyl) amine-induced Pancreatic Carcinogenesis in Hamsters
Akika SAKAMOTO1), Masayuki MITSUI2), Kazutoshi TAMURA1), Masahiro TSUTSUMI3)
1)Division of Pathology, Bozo Research Center Inc., 2)Mitsui Consulting, 3)Saiseikai Chuwa Hospital
Journal of Toxicologic Pathology 23 (suppl) 27-27, 2010.
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P-26 A Novel Immunohistochemical Marker, Integrin αvβ3 for BOP-induced Early Lesions of Pancreatic Ductal Carcinoma in Hamsters
Tsukasa KITAHASHI1), Mitsuyoshi YOSHIMOTO2), Toshio IMAI1)
1)Central Animal Lab. Natl. Cancer Ctr. Res. Inst., 2)Cancer Prev. Basic Res. Project. Natl. Cancer Ctr. Res. Inst.
Journal of Toxicologic Pathology 23 (suppl) 28-28, 2010.
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P-27 Effects of Propolis on Inflammation-related Rat Colon Carcinogenesis Induced by DMH and DSS
Yui SOKUZA1), Anna KAKEHASHI1), Shotaro YAMANO1), Yumi OBO1), Shohei KANIE1), Hideki WANIBUCHI1)
1)1st Dept. Pathol., Osaka City Univ. Grad., Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 28-28, 2010.
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P-28 Suppression of inflammation-associated colonic tumorigenesis in Min mice with a cyclooxygenase-2 inhibitor
Tetsuya TUKAMOTO1), 2), Liang SHI2), Ayumi SAITO2), 3), Takeshi TOYODA2), Shinji TAKASU2), 4), Noriko SAITO2), Masami YAMAMOTO2), 5), Takuji TANAKA6), Masae TATEMATSU2), 7)
1)1st Dept. Pathol., Fujita Health Univ. Sch. Med., 2)Div. Oncol. Pathol., Aichi Cancer Ctr. Res. Inst., 3)Dept. Pathol. Matrix Biol., Mie Univ. Grad. Sch. Med., 4)Cancer Prev. Basic Res. Project, Natl. Cancer Ctr. Res. Inst., 5)Sch. Vet. Nurs. Tech., Nippon Vet. Life Sci. Univ., 6)Dept. Tumor Pathol., Kanazawa Med. Univ., 7)Japan Bioassay Res. Ctr.
Journal of Toxicologic Pathology 23 (suppl) 29-29, 2010.
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P-29 Effects of adriamycin on the development of hereditary glomerular lesions in infant ICGN mice.
Kaoru INOUE, Midori YOSHIDA, Kaoru IRIE, Miwa TAKAHASHI, Yohei SAKAMOTO, Yoshikazu TAKETA, Akiyoshi NISHIKAWA
Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 23 (suppl) 29-29, 2010.
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P-30 Cancer cell death by capsaicin treatments
Makoto ASAMOTO, Mariko HOSHIKAWA, Aya NAIKI-ITO, Tomoyuki SHIRAI
Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci.
Journal of Toxicologic Pathology 23 (suppl) 30-30, 2010.
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P-31 Hypothermia and Related-Lesions in Rats Treated With a Single Dose of Chlorpromazine
Keisuke KITAURA, Makoto SATO, Kouhei MATSUSITA, Takanori MINAMI, Satoshi MATSUMOTO
Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 30-30, 2010.
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P-32 Effects of fasting and refeeding on hematopoietic cells in bone marrow
Takashi YAMAGUCHI, Shuji OGAWA, Toshiko KINOMOTO, Miwa SAWADA, Masataka WASHIZUKA, Yukinori MERA
Zeria pharmaceutical Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 31-31, 2010.
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P-33 Chronic Toxicity and Carcinogenicity of Dietary Administered Magnesium Chloride in F344 Rats
Shigeaki TAKAMI, Young-Man CHO, Kumiko OGAWA, Akiyoshi NISHIKAWA
Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 23 (suppl) 31-31, 2010.
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P-34 A 90-day Feeding Toxicity Study of L-Proline in Fischer 344 Rats
Yukie TADA, Norio YANO, Hiroshi TAKAHASHI, Katsuhiro YUZAWA, Hiroshi ANDO, Yoshikazu KUBO, Akemichi NAGASAWA, Norio OHASHI, Akio OGATA, Dai NAKAE
Tokyo Metropolitan Institute of Public Health, Department of Environmental Health and Toxicology
Journal of Toxicologic Pathology 23 (suppl) 32-32, 2010.
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P-35 A Subchronic Feeding Toxicity Study of Nisin A, An Antimicrobial Peptide Produced by Lactococcus Lactis Subsp. Lactis, in Rats
Miyuki OGAWA1), Akihiro Hagiwara1), Norio Imai1), Jonathan Delves-Broughton2), Kazuo Yasuhara3), Shim-mo Hayashi3)
1)DIMS Institute of Medical Science, Inc., 2)Danisco Beaminster Ltd., 3)San-Ei Gen F.F.I., Inc.
Journal of Toxicologic Pathology 23 (suppl) 32-32, 2010.
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P-36 Effects of Magnetite Nanoparticles on Lungs of Fischer 344 Rats after a Single Intratracheal Instillation.
Dai NAKAE, Yukie TADA, Norio YANO, Hiroshi TAKAHASHI, Katsuhiro YUZAWA, Hiroshi ANDO, Yoshikazu KUBO, Akemichi NAGASAWA, Norio OHASHI, Akio OGATA
Tokyo Metropolitan Institute of Public Health, Department of Environmental Health and Toxicology
Journal of Toxicologic Pathology 23 (suppl) 33-33, 2010.
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P-37 Pulmonary Toxicity of Intratracheally Instilled Multiwall Carbon Nanotubes in Male Fischer 344 Rats
Shigetoshi AISO, Yumi UMEDA, Hideki SENOH, Kenji TAKANOBU, Kasuke NAGANO, Shoji FUKUSHIMA
Japan Bioassay Research Center
Journal of Toxicologic Pathology 23 (suppl) 33-33, 2010.
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P-38 Investigation for Thrombogenic Mechanisms in the Lungs of Phenylhydrazine-treated Rats
Hiroko SATO, Tetsuya SAKAIRI, Fumiko SANO, Hisako FUJIMURA, Eisuke KUME, Jiro SUGIMOTO, Kazuyuki KITAMURA, Mamoru MUTAI
Safety Research Laboratory, Mitsubishi Tanabe Pharma Corporation
Journal of Toxicologic Pathology 23 (suppl) 34-34, 2010.
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P-39 A Study on the ultrastructure of spontaneous changes in the urinary tract of cynomolgus monkeys
Hirofumi HATAKEYAMA, Yoshihiro TAKEI, Hiroshi SATOH, Haruko KOIZUMI, Mitsutoshi WATANABE, Akihito SHIMOI
Ina Research Inc., Safety Research Center, Pathology Department
Journal of Toxicologic Pathology 23 (suppl) 34-34, 2010.
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P-40 Morphological Study of Deposits Associated with Accumulation of α2u-Globulin in Renal Tubular Epithelium
Shino KUMABE, Yutaka NAKAHARA, Takafumi OSHIKATA, Koshirou KATOKU, Mikio MITSUISHI, Masao HAMAMURA
Mitsubishi Chemical Medience
Journal of Toxicologic Pathology 23 (suppl) 35-35, 2010.
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P-41 Thy-1 Expressing Mesenchymal Cells in Rat Nephrogenesis, in Correlation with Cells Immunoreactive for α-Smooth Muscle Actin and Vimentin
Takahiro YUASA1), Takeshi IZAWA1), Mitsuru KUWAMURA1), Jyoji YAMATE1)
1Laboratory of Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University
Journal of Toxicologic Pathology 23 (suppl) 35-35, 2010.
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P-42 Mechanisms of testicular toxicity of acrylamide in rats： the interaction with a nuclear protein protamine.
Kaoru IRIE, Midori YOSHIDA, Miwa TAKAHASHI, Takashi UMEMURA, Akiyoshi NISHIKAWA
Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 23 (suppl) 36-36, 2010.
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P-43 Lipofuscin Deposition in the Retinal Epithelial Cells of Aging Cynomolgus Monkey (Macaca fascicularis)
Osamu KATSUTA, Chinami KIKKAWA, Miwa YOSHIMI
Santen Pharmaceutical Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 36-36, 2010.
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P-44 Histopathological Changes in Cerebrums of Middle-aged Monkeys
Xiuying YANG, Rinya KODAMA, Yuji SASAKI, Shuichiro IWASHIGE, Yohei TANIGAWA, Tsuyoshi YOSHIKAWA, Takaharu NAGAOKA, Yasuhiro KAMIMURA, Hiroshi MAEDA
Shin Nippon Biomedical Laboratories, Ltd.
Journal of Toxicologic Pathology 23 (suppl) 37-37, 2010.
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P-45 Quantifying Huntingtin Protein Aggregates in a Transgenic Mouse Model of Huntington's Disease
Kevin LIANG1), Reiko NISHIGUCHI2)
Aperio Technologies
Journal of Toxicologic Pathology 23 (suppl) 37-37, 2010.
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P-46 Investigation of a new pituitary tumor classification marker in rat
Hironobu YASUNO, Yumiko MIYAMOTO, Yoshimasa ISHIMURA, Hitoshi KANDORI, Hisashi ANAYAMA, Mitsuhiro HIRODE, Ryo FUKUDA
Development Research Center, Takeda Pharmaceutical Company, Limited
Journal of Toxicologic Pathology 23 (suppl) 38-38, 2010.
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P-47 A Case of Thoracic Fungal Granuloma Caused by Aspergillus spp. Observed in A Cynomolgus Macaque (Macaca fascicularis).
Hirofumi YAMAUCHI1), Yuichi TAKAI1), Emiko MAEDA1), Hideki YAMASAKI1), Takeshi WATANABE1), Yoko HARA1), Fumi MURAI1), Ryo FUKUDA1)
1)Development Research Center, Takeda Pharmaceutical Company Limited
Journal of Toxicologic Pathology 23 (suppl) 38-38, 2010.
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P-48 Spontaneous Myocardial Necrosis and Ischemic Lesions of the Brain in a Beagle Dog
Kohei MATSUSHITA, Makoto SATO, Keisuke KITAURA, Takanori MINAMI, Satoshi MATSUMOTO
Department of Toxicology, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 39-39, 2010.
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P-49 Pathological Features of Paraprostatic Cyst in a Dog
Takeshi IZAWA1), Katsumi SOUMA1), Mami AOTA2), Hitoshi SHIMAZAKI2), Takashi HASEGAWA2), Mitsuru KUWAMURA1), Jyoji YAMATE1)
1)Veterinary Pathology, 2)Veterinary Medical Center, Osaka Prefecture University
Journal of Toxicologic Pathology 23 (suppl) 39-39, 2010.
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P-50 A case of the spontaneous cholelithiatis in young female Wistar-Hannover rat.
Takamasa NUMANO1), Akihiro HAGIWARA1), Yuko DOI1), Hironao NAKASHIMA1), Hiroshi ABE2), Fumio FURUKAWA1)
1)DIMS Institute of Medical Science, Inc., 2)Department of Human Pathology, Juntendo University School of Medicine.
Journal of Toxicologic Pathology 23 (suppl) 40-40, 2010.
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P-51 Enterocyst in Rat Ileum
Takafumi OSHIKATA, Shino KUMABE, Yutaka NAKAHARA, Koshirou KATOKU, Mikio MITSUISHI, Hiromi YAMAGUCHI, Emiko KUWASAKI, Masao HAMAMURA
Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 23 (suppl) 40-40, 2010.
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P-52 Automated Analysis of Islet Morphology in Diabetes Research
Kate LILLARD-WETHERELL1), Stan Krajewski2), David YOUNG3), Steven POTTS1)
1Aperio, 2Burnham Institute, 3Flagship Biosciences LLC
Journal of Toxicologic Pathology 23 (suppl) 41-41, 2010.
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P-53 Pathological Characteristics of Streptozotocin and Alloxan-induced Diabetic Dogs
Saori MATSUO, Shuji HAYASHI, Masaki Yamazaki, Tomomi SOSHIN, Kaori ISOBE, Akio MIYOSHI, Atsuhiko KATO, Masami SUZUKI
Chugai Pharmaceutical Co.,Ltd., Safety Assessment Dept.
Journal of Toxicologic Pathology 23 (suppl) 41-41, 2010.
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P-54 Dental Caries and Caries-related Periodontal Disease in Alloxan-induced Diabetic Rats
Yutaka NAKAHARA1), Hideyuki WATANABE1), Shino KUMABE1), Takafumi OSHIKATA1), Koshirou KATOKU1), Mikio MITSUISHI1), Emiko KUWASAKI1), Masao HAMAMURA1)
1)Dep. Pathol., Mitsubishi Chemical Medience Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 42-42, 2010.
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P-55 Enhanced Tumorigenesis of Forestomach Tumors Induced by N-Methyl-N'-nitrosoguanidine in Rats with Hypoinsulinemic Diabetes
Yasushi KODAMA1), Kiyokazu OZAKI2), Tomoya SANO2), Tetsuro MATSUURA2), Isao NARAMA2)
1)Laboratory of Molecular and Cellular Pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, 2)Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University
Journal of Toxicologic Pathology 23 (suppl) 42-42, 2010.
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P-56 Establishment of Invasive Prostate Cancer Model of TRAP Rat
Ne LONG1), Satoru TAKAHASHI1), Takuya OYABU1), Tomoyuki SHIRAI1)
1)Dept. of Exp. Pathol. & Tumor Biol., Nagoya City Univ.
Journal of Toxicologic Pathology 23 (suppl) 43-43, 2010.
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P-57 LAT1 Antagonists Suppressed N-methyl-N'-nitro-N-nitrosoguanidine Induced Rat Gastric Carcinogenesis
Kenta ISHIDA1), Tomoko MUTO2), Masaya MOTOHASHI1), Yasuko KOBAYASHI1), Kai IMAI1), Shin WAKUI1)
1)Dept. Toxicol., Azabu Univ. Sch. Vet. Med., 2)CERI, 3)Kyorin Univ. Sch. of Med., 4)Osaka Univ. Grad. Sch. Med., 5)J-Pharma Co.,Ltd
Journal of Toxicologic Pathology 23 (suppl) 43-43, 2010.
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P-58 Male-Female Rats Gastric Carcinogenesis Induced by N-methyl-N'-nitro-N-nitrosoguanidine phthalate
Masaya MOTOHASHI1), Tomoko MUTO2), Kenta ISHIDA1), Yasuko KOBAYASHI1), Kai IMAI1), Shin WAKUI1)
1)Dept. Toxicol., Azabu Univ. Sch. Vet. Med., 2)CERI
Journal of Toxicologic Pathology 23 (suppl) 44-44, 2010.
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P-59 Preventive Effect of Caffeic Acid Phenethyl Ester on Gastric Carcinogenesis in Helicobacter pylori-Infected Mongolian Gerbils
Takeshi TOYODA1), †), Shinji TAKASU1), 2), Liang SHI1), Masae TATEMATSU1), 3), Noriko SAITO1), Ayumi SAITO1), 4), Masami YAMAMOTO1), 5), Tetsuya TSUKAMOTO1), 6)
1)Div. Oncol. Pathol., Aichi Cancer Ctr. Res. Inst., 2)Cancer Prev. Basic Res. Project, Natl. Cancer Ctr. Res. Inst., 3)Japan Bioassay Res. Ctr., 4)Dept. Pathol. Matrix Biol., Mie Univ. Grad. Sch. Med., 5)Sch. Vet. Nurs. Tech., Nippon Vet. Life Sci. Univ., 6)1st Dept. Pathol., Fujita Health Univ. Sch. Med., †)Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 23 (suppl) 44-44, 2010.
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P-60 Hepatocarcinogenicity mechanism of piperonyl butoxide in mice
Masaomi KAWAI1), 2), Yukie SAEGUSA1), 2), Sayaka KEMMOCHI1), 2), Keisuke SHIMAMOTO1), 2), Yuji ISHI3), Takashi UMEMURA3), Makoto SHIBUTANI1), Kunitoshi MITSUMORI1)
1)Lab. of Vet. Pathol., Tokyo Univ. of Agri. & Tech., 2)Pathog. Vet. Sci., Unit. Grad. Sch. Vet. Sci., Gifu Univ., 3)Div. of Pathol., Natl. Inst. of Hlth. Sci.
Journal of Toxicologic Pathology 23 (suppl) 45-45, 2010.
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P-61 Molecular Pathological Analysis on the Hepatocellular Tumor Promoting Effect of Indole-3-Carbinol (13C) in Hepatectomized Rats
Keisuke SHIMAMOTO1), Masaomi KAWAI1), 2), Yukie SAEGUSA1), 2), Sayaka KEMMOCHI1), 2), Makoto SHIBUTANI1), Kunitoshi MITSUMORI1)
1)Lab. of Vet. Pathol., Tokyo Univ. of Agricul. & Techonol., 2)Path. Vet. Sci., United Grad. Sch. of Vet. Sci., Gifu Univ.
Journal of Toxicologic Pathology 23 (suppl) 45-45, 2010.
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P-63 Epigenetic Alteration in the Gene Expression Involved in the Enhancing Effects of Chromated Copper Arsenate (CCA) on Skin Carcinogenesis
Naofumi TAKAHASHI, Satoru YAMAGUCHI, Ryoichi OHTSUKA, Makio TAKEDA, Aya OHNUMA, Yukiko KASHIMOTO, Toshinori YOSHIDA, Maki KUWAHARA, Nobuaki NAKASHIMA, Takanori HARADA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 23 (suppl) 46-46, 2010.
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P-64 Involvement of Bone Marrow Derived Cells in Helicobacter pylori-infected Mouse Gastric Carcinogenesis
Shinji TAKASU1), 2), Takeshi TOYODA1), Liang SHI1), Osamu TAGUCHI3), Masae TATEMATSU1), 4), Tetsuya TSUKAMOTO1), 5)
1)Div. Oncol. Pathol., Aichi Cancer Ctr. Res. Inst., 2)Cancer Prev. Basic Res. Project, Natl. Cancer Ctr. Res. Inst., 3)Div. Mol. Pathol., Aichi Cancer Ctr. Res. Inst., 4)Japan Bioassay Res. Ctr., 5)Dept. of Pathology, Fujita Health Univ., Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 46-46, 2010.
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P-65 Effect of Angiotensin II Receptor Antagonist Losartan in Preventing Mouse Colorectal Cancer
Liang SHI1), Takeshi TOYOTA1), 2), Shinji TAKASU1), 3), Noriko SAITO1), Ayumi SAITO1), 4), Masae TATEMATSU1), 5), Tetsuya TSUKAMOTO1), 6)
1Div. Oncol. Pathol., Aichi Cancer Ctr. Res. Inst., 2Dept. Pathol III., Nat. Insti of Health Sci. Bio. Safety Res. Ctr., 3Nat Cancer Ctr. Res. Inst., 4Univ. Mie. Regeneration Pathol., 5Japan Bioassay Res. Ctr., 6Dept. Pathol., Fujita Health Univ. Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 47-47, 2010.
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P-66 Sensitivity of a hypercholesterolemic mice model to AOM/DSS-induced colon carcinogenesis
Takeru OYAMA1), Yumiko YASUI1), Shigeyuki SUGIE1), Takuji TANAKA1), 2)
1)Dept. of Oncologic Pathology, Kanazawa Med. Univ., 2)Tokai Cytopathology Inst. Cancer Res. and Prev.
Journal of Toxicologic Pathology 23 (suppl) 47-47, 2010.
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P-67 Subsequent Report on Spontaneous Colon Carcinoma of Wistar-Furth Rat
Makoto MIYAMOTO
Pathology Division, Iseikai Japan Hospital.
Journal of Toxicologic Pathology 23 (suppl) 48-48, 2010.
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P-68 Lack of Effects of Isoleucine and Leucine at Early Stage of BBN-induced Rat Bladder Carcinogenesis
Xiaoli XIE, Shotaro YAMANO, Anna KAKEHASHI, Yui SOKUZA, Keigi CHIN, Hideki WANIBUCHI
1st Dept. Pathol., Osaka City Univ., Grad., Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 48-48, 2010.
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P-69 Effects of Dimethylmonothioarsinic Acid on Bladder Urothelium
Naoto SUGA1), Akihiro KANAGAWA1), 2), Takanori YAMADA1), Kaoru YOSHIDA1), Ginji ENDO2), Min WEI1), Hideki WANIBUCHI1)
1)Department of Pathology, 2)Department of Preventive Medicine and Environmental Health, Osaka City Univ., Grad., Sch. Med.
Journal of Toxicologic Pathology 23 (suppl) 49-49, 2010.
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P-70 Tumor modifying activity in the urinary bladder of horseradish extract in F344 rats
Young-Man CHO1), Toshio IMAI1), 2), Shigeaki TAKAMI1), Kumiko OGAWA1), Akiyoshi NISHIKAWA1)
1)Div. Pathol., Natl. Inst. Health Sci., 2)Ctr. Anim. Lab., Natl. Cancer Ctr. Res. Inst.
Journal of Toxicologic Pathology 23 (suppl) 49-49, 2010.
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P-71 Immunohistochemical localization of Breast Cancer Resistance Protein (BCRP) in normal tissues of Rats and Mice
Minoru Ando, Shoichi Kado, Yuriko Nagata, Chie Hata, Tomo Suzuki, Toshihide Kobayashi, Kazumi Uchida
Safety Research Center, Yakult Central Institute for Microbiological Research
Journal of Toxicologic Pathology 23 (suppl) 50-50, 2010.
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P-72 Inhibitory effects of pentachlorophenol, a sulfotransferase inhibitor, on in vivo mutagenicity and DNA damage in the kidneys of gpt delta mice treated with lucidin-3-O-primeveroside
Yuji ISHII1), Yuta SUZUKI1), Disuke HIBI1), Meilan JIN1), Yukio KODAMA2), Takashi UMEMURA1), Takehiko NOHMI3), Akiyoshi NISHIKAWA1)
1)Div. Pathol., 2)Div. Toxcol., 3)Div. Genet. & Mutagen., NIHS
Journal of Toxicologic Pathology 23 (suppl) 50-50, 2010.
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P-73 Prediction of early detection of radiation-induced renal tumors in fetuses and children
Toshiaki KOKUBO1), 2), Shizuko KAKINUMA1), Tetsu NISHIKAWA1), Yoshiya SHIMADA1), Okio HINO2)
1)National Institute of Radiological Sciences, 2)Juntendo University
Journal of Toxicologic Pathology 23 (suppl) 51-51, 2010.
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P-74 Chemopreventive Effects of Capsaicin and Silymarin in F344 gpt Delta Transgenic Rat.
Naomi TOYODA-HOKAIWADO1), Yumiko YASUI2), Mina MURAMATSU1), Kenichi MASUMURA1), Takuji TANAKA2), Takehiko NOHMI1)
1)Div. Genetics & Mutagenesis, Natl. Inst. Health Sci., 2)Div. Oncol. Pathol., Kanazawa Med. Univ.
Journal of Toxicologic Pathology 23 (suppl) 51-51, 2010.
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P-75 Modifying Effects of Co-treatment with Tocotrienol on in vivo Mutagenicity and Preneoplastic Lesion Development in the Liver of F344 gpt delta rats Exposed to Diethylnitrosamine
Tomoki INOUE1), Daisuke HIBI1), Naomi TOYODA-HOKAIWADO2), Masako TASAKI1), Toshiya OKAMURA1), Meilan JIN1), Yuta SUZUKI1), Yuji ISHII1), Takehiko NOHMI2), Takashi UMEMURA1), Akiyoshi NISHIKAWA1)
1)Division of Pathology, 2)Division of Genetics and Mutagenesis, National Institute of Health Sciences
Journal of Toxicologic Pathology 23 (suppl) 52-52, 2010.
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P-76 Occurrence of spontaneous inflammation of molar gingiva in rats
Aya MORITO, Yuki MOMOZAWA, Yoshikazu TAKETA, Etsuko OHTA, Kyoko NAKANO, Akira INOMATA, Kazuhiro HAYAKAWA, Satoru HOSOKAWA, Toyohiko AOKI, Kazuo TSUKIDATE, Jiro SONODA
Drug Safety Japan, Global Drug Safety Biopharmaceutical Assessments Core Function Unit, Eisai Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 52-52, 2010.
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P-77 Effect of Olopatadine Hydrochloride on Allergic Ear Auricular Dermatitis by Repeated Topical Application of Oxazolone in Mice
Chie TAKADA, Tadashi TAMURA, Yui MANABE, Minami IMAIZUMI, Kensuke MYOJO, Hisashi IKEGAMI, Naoya KIMOTO, Kazuo SUZUKI, Itaru YAMAGUCHI, Katsumi TAKABA
Kyowa Hakko Kirin Co.,Ltd
Journal of Toxicologic Pathology 23 (suppl) 53-53, 2010.
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P-78 Morphological effects by Treatment with Compound X, a Possible Sterol Synthesis Inhibitor, in Rat Palatogenesis. (II).
Koshirou KATOKU1), Shino KUMABE, Yutaka NAKAHARA1), Takafumi OSHIKATA1), Mikio MITSUISHI1), Akemi KAWAKAMI1), Masao HAMAMURA1), Naoki IKEMI2)
1)Mitsubishi Chemical Medience, 2)Ootsuka Chemical
Journal of Toxicologic Pathology 23 (suppl) 53-53, 2010.
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P-79 Observation of neonatal brain in a rat valproate-induced autism model： comparison with changes in fetal and neonatal brain
Makiko KUWAGATA1), 2), Tetsuo OGAWA2), 3), Kenji USUMI1), Fumiaki KUMAGAI1), Yoshiaki SAITO1), Seiji SHIODA3), Tomoko NAGATA1)
1)Pathology Lab., Hatano Research Institute, FDSC, 2)Dep. of Anatomy I, Showa Univ. Sch. of Med., 3)Anti-aging, Funded Res. Labs., Showa Univ.
Journal of Toxicologic Pathology 23 (suppl) 54-54, 2010.
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P-80 N, N’-bis(2-chloroethyl)-N-nitrosourea (BCNU)-induced apoptosis of neural progenitor cells in the developing fetal rat brain
Tsuyoshi Yamaguchi1, 2, Hiroyuki Kanemitsu1, Satoshi Yamamoto1, Masahiko Komatsu1, Hiroyuki Uemura1, Mizuyo Katsumata1, Hiromi Hisatsune1, Kazutoshi Tamura1, Tomoyuki Shirai2
1Bozo Research Center Inc., 2Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
Journal of Toxicologic Pathology 23 (suppl) 54-54, 2010.
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P-81 Chronological Changes of 2’, 3’-Cyclic Nucleotide 3’-Phosphodiesterase (CNPase) in Spongy Change of Central Nervous System Induced by Repeated Oral Dose of Hexachlorophene (HCP) and Cuprizone (CPZ) in Rats
Takeshi KANNO, Satoshi SASAKI, Naoaki YAMADA, Kazufomi KAWASAKO, Minoru TSUCHITANI
Mitsubishi Chemical Medience Corp.
Journal of Toxicologic Pathology 23 (suppl) 55-55, 2010.
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P-82 Effect of Busulfan on Neonatal Cerebellar Peduncle in Rats
Tsubasa SAITO, Ryo ANDO, Toko OHIRA, Megumi YAHATA, Nobuo NISHIMURA, Kazutoshi TAMURA
Division of Pathology, Bozo Research Center Inc.
Journal of Toxicologic Pathology 23 (suppl) 55-55, 2010.
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P-83 Lung and Testicular Development in Rats with Prenatal Perfluorooctane-sulfonate Exposure
Yasuko KOBAYASHI1), Tomoko MUTO2), Kenta ISHIDA1), Masaya MOTOHASHI1), Kai IMAI1), Shin WAKUI1)
1)Dept. Toxicol., Azabu Univ. Sch. Vet. Med., 2)CERI
Journal of Toxicologic Pathology 23 (suppl) 56-56, 2010.
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P-84 Characterization of Increased Reelin-expressing Cells in the Hippocampal Dentate Gyrus Induced by Developmental Hypothyroidism in Rats
Yukie SAEGUSA1), 2), Gye-Hyeong WOO4), Hitoshi FUJIMOTO4), Sayaka KEMMOCHI1), 2), Keisuke SHIMAMOTO1), 2), Masao HIROSE3), 4), Kunitoshi MITSUMORI1), Akiyoshi NISHIKAWA4), Makoto SHIBUTANI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agri. Tech., 2)United Grad. Sch. Vet. Sci., Gifu Univ., 3)Food Safety Commission, 4)Div. Pathol., Nat. Inst. Health Sci.
Journal of Toxicologic Pathology 23 (suppl) 56-56, 2010.
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P-85 Pathological Investigation of The Rat Pituitary Gland on The Low Dose Estrogenic Agent-Induced Delayed Effect
Yoshihide UEDA, Kiyoshi IMAI
Biosafety Research Center, Foods, Drugs and Pesticides (BSRC)
Journal of Toxicologic Pathology 23 (suppl) 57-57, 2010.
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P-86 Sequential Morphological Changes of Small Follicles in the Ovary Damaged by Prepubertal Exposure to Gamma Ray
Midori YOSHIDA1, Yoshikazu TAKETA1, Yoshiya SHIMADA2, Kaoru INOUE1, Tomomi MORIKAWA1, Miwa TAKAHASHI1, Yohei SAKAMOTO1, Gen WATANABE3, Kazuyoshi TAYA3, Akiyoshi NISHIKAWA1
1Div Pathol, NIHS, 2NIRS, 3Vet Physiol, TUAT
Journal of Toxicologic Pathology 23 (suppl) 57-57, 2010.
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P-87 Luteal Function-Related Gene Analysis of New and Old Corpora Lutea in Normal Cycling Rats using Laser Capture Microdissection
Yoshikazu TAKETA1, 2, 3, Midori YOSHIDA1, Kaoru INOUE1, Miwa TAKAHASHI1, Yohei SAKAMOTO1, Gen WATANABE4, Kazuyoshi TAYA4, Jyoji YAMATE3, Akiyoshi NISHIKAWA1
1Division of Pathology, National Institute of Health Sciences, 2Tsukuba, Drug Safety Japan, Eisai Co.,Ltd., 3Osaka Prefecture University, 4Tokyo University of Agriculture and Technology
Journal of Toxicologic Pathology 23 (suppl) 58-58, 2010.
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P-88 Investigation of Biomarkers using Drug-Derived Cardiotoxicity-Induced Rat
Hiroko KITAYAMA, Shigeo SUGIMOTO, Norifumi MATSUSHITA, Yasufumi KONDO, Kazuhiko BESSHI, Shuji YAMAGUCHI, Kazuo HAKOI
Tokushima Research Center, Taiho Pharmaceutical Co.Ltd.
Journal of Toxicologic Pathology 23 (suppl) 58-58, 2010.
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P-89 Possible Genomic Biomarkers for Chemically-induced Cardiotoxicity in Rats Explored Using a Toxicogenomics Approach
Yoko MORI, Yutaka TONOMURA, Chiaki KONDO, Takeki UEHARA, Mikinori TORII
Shionogi & Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 59-59, 2010.
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P-90 Gene Expression Analysis in the Skeletal Muscles of Dysferlin-deficient SJL and A/J Mice
Kinji KOBAYASHI, Takeshi IZAWA, Mitsuru KUWAMURA, Jyoji YAMATE
Laboratory of Veterinary Pathology, Division of Veterinary Sciences, Life and Environmental Sciences, Osaka Prefecture University
Journal of Toxicologic Pathology 23 (suppl) 59-59, 2010.
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P-91 Reducing the Toxicity of Therapeutic Antibodes by Epitope Modification - Histopathological Evaluation in Mice Administered Anti-Desmoglein-3 Antibodies -
Chie KATO1), Etsuko FUJII1), Akio MIYOSHI1), Hirotake TAKAI1), Kenji ADACHI1), Atsuhiko KATO1), Masami SUZUKI1)
1)Safety Assessment Dept., Chugai Pharmaceutical Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 60-60, 2010.
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P-92 Background variation of histopathological changes of the SPF pigs
Yuki ISHIZAWA, Satomi TOMITA, Noriko SHINYA, Mika KIYOKAWA, Miho FUJIMOTO, Shinichiro NISHIMURA, Hajime MATSUI, Takamichi SHIGAKI
The Chemo-Sero-Therapeutic Research Institute
Journal of Toxicologic Pathology 23 (suppl) 60-60, 2010.
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P-93 Characterization of spontaneous neoplastic lesions in long term maintained BRIHan：WIST@Jcl (GALAS) rats； especially hematopoietic neoplasic lesions
Maki KUWAHARA, Aya OHNUMA, Naofumi TAKAHASHI, Yukiko KASHIMOTO, Sayuri Kojima, Yuko CHIBA, Toshinori YOSHIDA, Nobuaki NAKASHIMA, Takanori HARADA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 23 (suppl) 61-61, 2010.
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P-94 Morphological Study of Lymphoid Organs in Cynomolgus Monkeys： Quantitative Analyses for Immunotoxicity Evaluation
Akiko MORIYAMA1), 2), Junko FUJISHIMA1), Tomohiro FURUKAWA1), Tsuyoshi YOSHIKAWA1), Rinya KODAMA1), Yuji SASAKI1), Xiuying YANG1), Hiroshi MAEDA1), Takuya HIRAI2), 3), Ryoji YAMAGUCHI2), 3)
1)Shin Nippon Biomedical Laboratories, Ltd., 2)The United Graduate School of Veterinary Science, Yamaguchi University, 3)Miyazaki University, Department of Veterinary Pathology
Journal of Toxicologic Pathology 23 (suppl) 61-61, 2010.
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P-95 Investigation of Age-and Sex-differences in the Thymus and Spleen with Immunohistochemistry in Crl：CD(SD) Rats
Rinya KODAMA, Akiko MORIYAMA, Takanobu OKAZAKI, Tamio SATO, Shuichiro IWASHIGE, Yohei TANIGAWA, Noriaki TOKUNAGA, Yuji SASAKI, Tadashi KOGA, Xiuying YANG, Yasuhiro KAMIMURA, Hiroshi MAEDA
Shin Nippon Biomedical Laboratories, Ltd.
Journal of Toxicologic Pathology 23 (suppl) 62-62, 2010.
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P-96 Comparison of Historical Control Data in Carcinogenicity Studies amongst 3 Strains (NMRI, CD-1, B6C3F1) of Mice.
Hijiri IWATA, Klaus WEBER, Tanja RAZINGER
Harlan Laboratories Ltd.
Journal of Toxicologic Pathology 23 (suppl) 62-62, 2010.
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P-97 A Case of Malignant Mesothelioma Showing Sarcomatoid Growth Pattern in Abdominal Cavity in a Female F344 Rat.
Aya OHNUMA1), Naofumi TAKAHASHI1), Yukiko KASHIMOTO1), Toshinori YOSHIDA1), Maki KUWAHARA1), Yuko CHIBA1), Nobuaki NAKASHIMA1), Takanori HARADA1)
1)The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 23 (suppl) 63-63, 2010.
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P-98 A Case Report of the Malignant Ameloblastoma in a Fisher 344 rat
Kenji TAKANOBU, Hideki SENOH, Yumi UMEDA, Shigetoshi AISO, Kasuke NAGANO, Shoji FUKUSHIMA
Japan Bioassay Research Center
Journal of Toxicologic Pathology 23 (suppl) 63-63, 2010.
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P-99 Spontaneous Thyroid Follicular Adenoma with Oncocytic Features in a Cynomolgus Monkey
Akiko ANAGAWA1), Shiro FUJIHIRA1), Yuichi MURAKAMI1), Tsuneo FUJII2), Yoshimasa OKAZAKI1), Shunji NAKATSUJI1), Yuji OISHI1), Masahiro MATSUMOTO1)
1)Tox. Pathol., Drug Safety Research Lab., Astellas Pharma Inc., 2)General Tox., Drug Safety Research Lab., Astellas Pharma Inc.
Journal of Toxicologic Pathology 23 (suppl) 64-64, 2010.
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P-100 Histological identification of unspecified large cells with rich cytoplasm observed in the small intestine of common marmosets.
Kensuke MYOJO, Yui MANABE, Minami IMAIZUMI, Chie TAKADA, Hisashi IKEGAMI, Mayumi TUGE, Hiroyuki SUMIDA, Kazuo USHIDA, Itaru YAMAGUCHI, Naoya KIMOTO, Teruyoshi IMADA, Katsumi TAKABA
Kyowa Hakko Kirin Co.,Ltd
Journal of Toxicologic Pathology 23 (suppl) 64-64, 2010.
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P-101 So-called Buphthalmos Developed in Albino Rabbits ： Congenital Glaucoma
Chinami KIKKAWA1), Osamu KATSUTA1), Miwa YOSHIMI1), Isao NARAMA2)
1)Santen Pharmaceutical Co.,Ltd., 2)Setsunan University
Journal of Toxicologic Pathology 23 (suppl) 65-65, 2010.
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P-102 Keratoconus in a Cynomolgus Monkey
Noriaki TOKUNAGA, Rinya KODAMA, Xiuying YANG, Tomoaki ARAKI, Masato SATO, Shuichiro IWASHIGE, Yohei TANIGAWA, Mie UCHIMURA, Keisuke ISHIMARU, Yuji SASAKI, Yasuhiro KAMIMURA, Hiroshi MAEDA
Shin Nippon Biomedical Laboratories, Ltd.
Journal of Toxicologic Pathology 23 (suppl) 65-65, 2010.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-103 Bilateral Cataract in a Cynomolgus Monkey
Yuji SASAKI, Rinya KODAMA, Shuichiro IWASHIGE, Xiuying YANG, Yasuhiro KAMIMURA, Hiroshi MAEDA
Shin Nippon Biomedical Laboratories, Ltd.
Journal of Toxicologic Pathology 23 (suppl) 66-66, 2010.
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P-104 Spontaneous Erythroid Leukemia in a 7-Week-Old Crl：CD (SD) Rat
Emi YAMAMOTO, Toshiyuki MARUYAMA, Koichi MASUNO, Kae FUJISAWA, Nobuo TAKASU, Noriko TSUCHIYA
Developmental Research Laboratories, Shionogi & Co.,Ltd.
Journal of Toxicologic Pathology 23 (suppl) 66-66, 2010.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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