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Journal of Toxicologic Pathology 26巻 suppl号

発行元
日本毒性病理学会
ISSN
0914-9198
ISSN（オンライン）
1881-915X
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開始頁
SL-1 The Role of the Toxicologic Pathologist in the Post-genomic Era
Robert R.Maronpot
Raleigh, North Carolina
Journal of Toxicologic Pathology 26 (suppl) 1-2, 2013.
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SS-1-1 Transgenic Animals for Evaluation of Carcinogenicity
Gary A.Boorman1), Victoria Laast2)
1)Covance Laboratories Inc., 2)Covance Pharmaceutical R&D (Shanghai) Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 3-3, 2013.
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SS-1-2 Contemporary NTP Toxicity and Carcinogenicity Testing Strategies
Susan A.Elmore
National Toxicology Program/National Institute of Environmental Health Sciences
Journal of Toxicologic Pathology 26 (suppl) 4-4, 2013.
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SS-1-3 Genomics Strategies in National Toxicology Program Toxicity and Carcinogenicity Testing
Mark J.Hoenerhoff
Investigative Pathology Group, Cellular and Molecular Pathology Branch Division of the National Toxicology Program National Institute of Environmental Health Sciences National Institutes of Health
Journal of Toxicologic Pathology 26 (suppl) 5-5, 2013.
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SS-1-4 Regulatory Requirements, Advantages, Disadvantages, and Relevance of Dogs, Monkeys and Small Models in Toxicity Testing
Klaus Weber
AnaPath GmbH
Journal of Toxicologic Pathology 26 (suppl) 6-6, 2013.
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SS-2-1 Environmental Response Study Using Model Animal System
Masayuki Yamamoto
Tohoku University Graduate School/School of Medicine
Journal of Toxicologic Pathology 26 (suppl) 7-7, 2013.
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SS-2-2 Development of a humanized liver model using immunodeficient mice
Hiroshi Suemizu
Biomedical Research Department, Central Institute for Experimental Animals
Journal of Toxicologic Pathology 26 (suppl) 7-7, 2013.
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SS-2-3 Hair Follicle Aging with Genotoxic Stress through Stem Cell Regulation
Emi Nishimura
Dept. of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University
Journal of Toxicologic Pathology 26 (suppl) 8-8, 2013.
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SS-2-4 New International Development of Alternatives to Animal Experiments (3Rs)
Tsutomu Miki Kurosawa
Osaka University Medical School
Journal of Toxicologic Pathology 26 (suppl) 8-9, 2013.
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O-01 Investigation of renal biomarkers in the urine, blood, and renal tissues in rat models of drug-induced nephrotoxicity.
Kazunori KUWATA1), Itsuko Nakamura1), Mika IDE1), Kouji KAWAI1), Hiroko SATO1), Satomi NISHIKAWA1), Masaharu TANAKA1)
1)Safety Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation
Journal of Toxicologic Pathology 26 (suppl) 10-10, 2013.
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O-02 Surfactant protein D is a useful biomarker for cyclophosphamide-induced interstitial pneumonia in rats
Tomo SUZUKI1), Isamu OOSUGA1), Katsuya SUZUKI1), Minoru ANDO, Yuriko NAGATA1), Chie HATA1), Ryota TOCHINAI1), Kazumi UCHIDA1), Toshihide KOBAYASHI1), Shoichi KADO1), Kimiyuki KANEKO1)
1)Yakult Central Institute for Microbiological Research
Journal of Toxicologic Pathology 26 (suppl) 10-10, 2013.
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O-03 Identification of MicroRNA Markers for Predicting Bladder Carcinogenicity of Chemicals in Rats
Min GI, Shotaro YAMANO, Minoru KATO, Masaki FUJIOKA, Anna KINOSHITA, Masayuki KANKI, Hideki WANIBUCHI
Dept. of Path., Osaka City Univ. Grad. Sch. Med.
Journal of Toxicologic Pathology 26 (suppl) 11-11, 2013.
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O-04 A serum tumor marker for preclinical trials of rat lung cancer model
Katsumi FUKAMACHI1), Yutaka OHSHIMA1), Mitsuru FUTAKUCHI1), Hiroyuki TSUDA2), Masumi SUZUI1)
1)Dept. Mol. Toxicol., Nagoya City Univ. Grad. Sch. Med. Sci., 2)Nanotoxicol. Project, Nagoya City Univ
Journal of Toxicologic Pathology 26 (suppl) 11-11, 2013.
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O-05 Bone Formation with the Marrow Tissue Observed in the Liver of KK-Ay Mice Used for NASH Model Examination Experiment
Takafumi OSHIKATA, Takeshi KANNO, Kazufumi KAWASAKO, Koshirou KATOKU, Mikio MITSUISHI, Azusa KOBAYASHI, Masao HAMAMURA
Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 26 (suppl) 12-12, 2013.
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O-06 Characteristic Clinical Course and Pathology of Multiple Sclerosis Model in Rats.
Satomi KIKUCHI1), Yoshihisa NAKANO1), Takashi TAKEUCHI1), Makoto MIYAUCHI1), Shigeki MATSUMOTO1), Kazunari NAKAO1)
1)Discovery research, Mochida pharmaceutical Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 12-12, 2013.
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O-07 Inhibitory Effect of Postnatal Treatment with Cyclopamine, a Hedgehog Signaling Inhibitor, on Medulloblastoma Development in Ptch 1 Heterozygous mice
Saori Matsuo1), Miwa Takahashi1), Kaoru Inoue1), Kaoru Irie1), Kei Tamura1), Kumiko Ogawa1), Akiyoshi Nishikawa2), Midori Yoshida1)
1)Division of Pathology, National Institute of Health Sciences, 2)Biological Safety Research Center, National Institute of Health Sciences
Journal of Toxicologic Pathology 26 (suppl) 13-13, 2013.
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O-08 Sampling Practices for Brain Evaluation in Adult Rats (Concepts for the Analysis of the Central Nervous System)
Peter Maslej1), Gabor Boros1)
1)CiToxLAB Hungary Ltd.
Journal of Toxicologic Pathology 26 (suppl) 13-13, 2013.
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O-09 Identification of gene marker sets that could predict the hepatocarcinogenicity and toxic phenotype in the rat liver.
Masayuki Kanki1),2), Min Wein2), Anna Kakehashi2), Shotaro Yamano2), Hideki Wanibuchi3)
1)Astellas Pharma Inc, 2)Osaka City University Medical School
Journal of Toxicologic Pathology 26 (suppl) 14-14, 2013.
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O-10 Examination of in vivo mutagenicity and carcinogenicity in the gpt delta rat with 2-AAF
Mai OKUMURA, Min WEI, Shotaro YAMANO, Masaki FUJIOKA, Yoshiyuki TAGO, Mitsuaki KITANO, Hideki WANIBUCHI
Department of Pathology, Osaka city university graduate school of Medicine
Journal of Toxicologic Pathology 26 (suppl) 14-14, 2013.
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O-11 Development of A Medium-Term Animal Model Using gpt delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity
Kohei MATSUSHITA1), Yuji ISHII1), Shinji TAKASU1), Ken KURODA1), Aki KIJIMA1), Takehiko NOHMI2), Kumiko OGAWA1), Takashi UMEMURA1)
1)Div. Path., Natl. Inst. Health Sci., 2)Bio. Saf. Res. Cent, Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 26 (suppl) 15-15, 2013.
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O-12 Identification of Gene Expression Profile Related to Aberration in Neuronal/Glial Development Induced by Maternal Exposure to 6-propyl-2-thiouracil in Rats.
Ayako SHIRAKI1),2), Hirotoshi AKANE1), Fumiyo SAITO3), Yumi AKAHORI3), Shinya IMATANAKA3), Megu ITAHASHI1),2), Liyun WANG1), Takumi OHISH1), Kazuhiko SUZUKI4), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agricul. And Technol., 2)Pathogen. Vet. Sci., United Grad. Sch. Vet. Sci., Gifu University., 3)Chem. Eval. Res. Inst. Chem. Assess. Res. Centr., 4)Lab. Vet. Toxicol., Tokyo Univ. Agricul. And Technol.
Journal of Toxicologic Pathology 26 (suppl) 15-15, 2013.
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O-13 Roles of the Colonic Stem cells in the Process of Epithelial Regeneration in Dextran Sulfate Sodium-Induced Colitis
Atsuko MURAI1), Akihiro HIRATA2), Manabu TAKAMATSU3), Toshiya KUNO3), Tokuma YANAI1), Akira HARA3)
1)Pathogenic Vet. Sci., Gifu Univ. United Graduate Sch. Vet. Sci., 2)Div. Animal Experiment, Life Sci. Res. Ctr., Gifu Univ., 3)Dept. Tumor Pathol., Gifu Univ. Graduate Sch. Med.
Journal of Toxicologic Pathology 26 (suppl) 16-16, 2013.
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O-14 Possibility of Cancer Initiating Cell of Bronchiolar Alveolar Stem Cell for Mice Lung SCC
Shotaro YAMANO, Min WEI, Masaki FUJIOKA, Anna KAKEHASHI, Hideki WANIBUCHI
Department of Pathology, Osaka city university graduate school of Medicine
Journal of Toxicologic Pathology 26 (suppl) 16-16, 2013.
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O-15 The Bovine Corneal Opacity and Permeability (BCOP) Test Method for Assessment of The Ocular Irritation：Histopathological Examination
Masatoshi FURUKAWA1), Masumi ROKUKAWA1), Takashi SAKAKIBARA1), Kota ITO1), Shiro FUJIHIRA1), Takeo HIRAGA2), Hajime KOJIMA3), Masao MATSUURA1)
1)Safety Research Institute for Chemical Compounds, Co.,Ltd., 2)Department of Veterinary Medicine, Rakuno Gakuen University, 3)National Institute of Health Sciences
Journal of Toxicologic Pathology 26 (suppl) 17-17, 2013.
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O-16 The Ratio of the Number of Atrophied Seminiferous Tubules and the Ratio of the Area of Leydig Cells in Minipigs
Tadashi ITOH, Shinsuke SUZUKI, Hisami MATSUSITA, Ken-ichi YOSHIJIMA, Tsuneo KOIKE, Shin-ya YABUKI, Jun IMAI, Hitoshi KIMURA
Nihon Bioresearch Inc.
Journal of Toxicologic Pathology 26 (suppl) 17-17, 2013.
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O-17 Utilizing the NOD/Shi-scid, IL-2Rgamma null mouse transplanted with human thyroid tissue
Etsuko FUJII1), YuJau CHEN2),3), Atsuhiko KATO1), Takeshi WATANABE1), Chie KATO1), Akio MIYOSHI1), Shuji HAYASHI1), Koichi MATSUBARA2),3), Yasuyuki ONISHI4), Masami SUZUKI1)
1)Research Division, Chugai Pharmaceutical, 2)Pharma Logicals Research, Singapore, 3)Chugai Pharmabody Research, Singapore, 4)Central Institute For Experimental Animals
Journal of Toxicologic Pathology 26 (suppl) 18-18, 2013.
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P-01 Mode of action of ethyl tertiary-butyl ether tumorigenicity in the rat liver： Evidence for oxidative stress induction via activation of CAR, PXR and PPARs
Anna KAKEHASHI1), Akihiro HAGIWARA2), Norio IMAI2), Min WEI1), Kasuke NAGANO3), Shoji FUKUSHIMA4), Hideki WANIBUCHI1)
1)Osaka City Univ. Grad. Sch. Med., 2)DIMS Inst. Med. Sci., Inc., 3)Nagano Toxicologic-Pathology Consulting, 4)Japan Bioassay Research Center
Journal of Toxicologic Pathology 26 (suppl) 19-19, 2013.
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P-02 Different Macrophage Populations in GST-P-Positive/Negative Liver Lesions in Cirrhosis Induced in Rats by Repeated Injections of Thioacetamide (TAA)
Kavindra WIJESUNDERA1), Takeshi IZAWA1), Chisa ICHIKAWA1), Anusha TENNAKOON1), Hiroshi MURAKAMI1), Hossain Md.GOLBAR1), Mitsuru KUWAMURA1), Jyoji YAMATE1)
1)Osaka Prefecture University, Laboratory of Veterinary Pathology
Journal of Toxicologic Pathology 26 (suppl) 19-19, 2013.
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P-03 Comparisons of Macrophages and Myofibroblasts Properties between Acute and Chronic Biliary Lesions Induced by α-naphthylisothiocyanate (ANIT) in Rats
Hossain M.GOLBAR, Takeshi IZAWA, Chisa ICHIKAWA, Miyuu TANAKA, Mitsuru KUWAMURA, Jyoji YAMATE
Osaka Pref Univ
Journal of Toxicologic Pathology 26 (suppl) 20-20, 2013.
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P-04 In vivo mutagenicity of potassium bromate in the kidneys of gpt delta mice： effects of combined treatment with nitrilotriacetic acid, a renal tumor promoter
Yuji ISHII1), Aki KIJIMA1), Shinji TAKASU1), Kohei MATSUSHITA1), Ken KURODA1), Yukio KODAMA2), Kumiko OGAWA1), Takashi UMEMURA1)
1)Div. Pathol., NIHS, 2)Div. Toxicol., NIHS
Journal of Toxicologic Pathology 26 (suppl) 20-20, 2013.
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P-05 Chemical structure-related mechanisms underlying in vivo mutagenicity induced by nitrofurantoin
Aki KIJIMA, Yuji ISHII, Shinji TAKASU, Kohei MATSUSHITA, Ken KURODA, Kumiko OGAWA, Takashi UMEMURA
Div. Pathol., NIHS
Journal of Toxicologic Pathology 26 (suppl) 21-21, 2013.
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P-06 Effects of Renin Inhibition on Glomerular Podocyte Injury in Osborne-Mendel Rats
Haruka SAKASHITA1), Kyohei YASUNO1), Saori ARAKI1), Tomoshige BABA1), Ryosuke KOBAYASHI1), Junichi KAMIIE2), Kinji SHIROTA1),2)
1)Research Institute of Biosciences, 2)Lab. Vet. Pathol., Azabu Univ.
Journal of Toxicologic Pathology 26 (suppl) 21-21, 2013.
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P-07 Evaluation of Wilms' tumor 1 negative podocyte in Puromycin aminonucleosido nephrosis rats
Go SUGAHARA1), Shin WAKABAYASHI2), Akane KASHIMURA2), Junhi KAMIIE2), Kinji SHIROTA1),2)
1)Research Institute of Biosciences, 2)Lab. Pathol., Azabu Univ.
Journal of Toxicologic Pathology 26 (suppl) 22-22, 2013.
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P-08 Anti-carcinogenesis effect of apocynin, NADPH oxidase inhibitor, on rat prpstate.
Shugo SUZUKI1,2), Shinya SATO1), Ne LONG1), Wanisa PUNFA1), Tomoyuki SHIRAI1), Satoru TAKAHASHI1)
1)Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci., 2)Pathol. Div., Nagoya City East Med. Ctr.
Journal of Toxicologic Pathology 26 (suppl) 22-22, 2013.
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P-09 Inhibitory effect of OBP-801 on Prostate Carcingenesis
Shinya SATO, Shugo SUZUKI, Aya NAIKI, Long NE, Tomoyuki SHIRAI, Satoru TAKAHASHI
Dept. of Exp. Pathol. And Tumor Biol., Nagoya City Univ.
Journal of Toxicologic Pathology 26 (suppl) 23-23, 2013.
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P-10 Modifying effect of castration on PhIP-induced prostate carcinogenesis by Nakagama method treatment
Shigeyuki SUGIE1), Takuji TANAKA1),2)
1)Murakami Memorial Hosp., Asahi Univ., 2)Tohkai Cytopathol. Inst., Cancer Res. Prev.
Journal of Toxicologic Pathology 26 (suppl) 23-23, 2013.
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P-11 The relationship between the tissue morphology and the quality of RNA in the PFA-AMeX processed samples： The application for LCM and DNA microarray analysis.
Atsuhiko KATO1), Takeshi WATANABE1), Yu J CHEN2), Motooki ASHIHARA1), Hiromichi TERASHIMA1), Hideaki MIZUNO1), Chie KATO1), Akio MIYOSHI1), Shuuji HAYASHI1), Kenji ADACHI1), Tsuneo ITO1), Koichi MATSUBARA2), Masami SUZUKI1)
1)Research Division, Chugai Pharmaceutical Co.,Ltd., 2)PharmaLogicals Research Pte. Ltd.
Journal of Toxicologic Pathology 26 (suppl) 24-24, 2013.
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P-12 Intestinal crypt response in X-irradiated mice
Tetsuya TSUKAMOTO1)
1)Fujita Health University School of Medicine
Journal of Toxicologic Pathology 26 (suppl) 24-24, 2013.
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P-13 Microarray Analysis of Liver and Colonic Mucosa in LETO and OLETF Rats Treated with Caloric Restriction and High Fat Diet
Chie TAKASU, Keisuke IZUMI
Dept. of Mol. and Environ. Pathol., Inst. of Health Biosciences, The Univ. of Tokushima Grad. Sch.
Journal of Toxicologic Pathology 26 (suppl) 25-25, 2013.
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P-14 Effects of High Fat Diet on the Polyp Formation in the Intestine of Min mice
Mayumi KAWABE1), Takamasa NUMANO1),2), Fumio FURUKAWA1), Hironao NAKASHIMA1), Kotaro TAMURA3), Yuji OISHI3)
1)DIMS Institute of Medical Science, Inc., 2)Nagoya City University Graduate School of Medical Sciences, Department of Molecular Toxicology, 3)Astellas Pharma Inc.
Journal of Toxicologic Pathology 26 (suppl) 25-25, 2013.
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P-15 Impacts of High Fat Diet-induced Obesity on Spontaneous Reporter Gene Mutations in gpt delta Mice
Shinji TAKASU1), Yuji ISHII1), Kohei MATSUSHITA1), Ken KURODA1), Aki KIJIMA1), Yukio KODAMA2), Kumiko OGAWA1), Takashi UMEMURA1)
1)Div. Pathol., Natl. Inst. Health Sci., 2)Div. Toxicol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 26 (suppl) 26-26, 2013.
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P-16 Prenatal Exposure of PFOS Modulate NNK-Induced Rat Lung Carcinogenesis
Masaya MOTOHASHI1), Shin WAKUI1),2),4), Isao TANAKA1), Masaru SHIRAI1), Noriko Oyama2), Tomoko MUTO2), Hiroyuki TAKAHASHI3), Hiroshi HANO3), Hitoshi ENDOU4)
1)Department of Toxicology, Azabu University School of Veterinary Medicine, 2)Department of Pathology, The Jikei University School of Medicine, 3)Drug Safety Testing Center Co.,Ltd., 4)J-Pharma Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 26-26, 2013.
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P-17 Modifying effect of ATI receptor blocker Losartan in mice lung carcinogenesis
Kyoko OKABE, Shotaro YAMANO, Min WEI, Masaki FUJIOKA, Xiaoli XIE, Masahiko KUSHIDA, Hideki WANIBUCHI
Department of Pathology, Osaka City University Graduate School of Medicine
Journal of Toxicologic Pathology 26 (suppl) 27-27, 2013.
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P-18 Nasal Lesion in Rats and Mice Exposed to Methylamine for 13 Weeks
Kenji TAKANOBU1), Hideki SENOH1), Yumi UMEDA1), Taku KATAGIRI1), Kasuke NAGANO2), Shigetoshi AISO1), Shoji FUKUSHIMA1)
1)Japan Bioassay Research Center (JBRC), Japan Industrial Safety and Health Association (JISHA), 2)Nagano Toxicologic-Pathologic Consulting
Journal of Toxicologic Pathology 26 (suppl) 27-27, 2013.
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P-19 Nasal Lesion in Rats and Mice Exposed to Methylamine for 104-weeks
Hideki SENOH1), Kenji TAKANOBU1), Yumi UMEDA1), Taku KATAGIRI1), Kasuke NAGANO2), Shigetoshi AISO1), Shoji FUKUSHIMA1)
1)Japan Bioassay Research Center (JBRC), Japan Industrial Safety and Health Association (JISHA), 2)Nagano Toxicologic-Pathologic Consulting
Journal of Toxicologic Pathology 26 (suppl) 28-28, 2013.
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P-20 Influence of the fiber length of multi-wall carbon nanotube on its ability to induce mesothelioma in rats
Yoshimitsu Sakamoto1), Akio Ogata1), Tetsuji Nishimura2), Akihiko Hirose3), Akiko Inomata1), Dai Nakae1),4)
1)Dept. Pharm. Environ. Sci., Tokyo Metropol. Inst. Pub. Health, 2)Teikyo Heisei Univ., 3)Div. Risk. Assessment, Natl. Inst. Heath Sci., 4)Tokyo Univ. Agricul.
Journal of Toxicologic Pathology 26 (suppl) 28-28, 2013.
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P-21 Pulmonary Toxicity in Rats Exposed to Multi-Walled Carbon Nanotube (MWCNT) for 13-Weeks
Yumi UMEDA, Kenji TAKANOBU, Hideki SENOH, Taku KATAGIRI, Shigetoshi AISO, Shoji FUKUSHIMA
Japan Bioassay Research Center (JBRC), Japan Industrial Safety and Health Association (JISHA)
Journal of Toxicologic Pathology 26 (suppl) 29-29, 2013.
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P-22 Effects of multiwall carbon nanotubes on the lung at 2 and 52 weeks after pulmonary instillation
Masumi SUZUI1), Takamasa NUMANO2), Katsumi FUKAMACHI1), Mitsuru FUTAKUCHI1), Hiroyuki TSUDA2)
1)Dept. of Mol. Toxicol. Grad. Sch. of Medical Sciences, Nagoya City Univ., 2)Lab. of Nano Toxicol. Project, Nagoya City Univ.
Journal of Toxicologic Pathology 26 (suppl) 29-29, 2013.
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P-23 Carcinogenic Potential of the Lung in Long Term after Inhalation of Carbon Nano Tubes
Mitsuru FUTAKUCHI1), Jiegou XU2), Katsumi FUKAMACHI1), Hiroyuki TSUDA2), Masumi SUZUI1)
1)Dept. of Molecular Toxi cology, 2)Nano Toxicology project, Nagoya City University Graduate School of Medical Sciences
Journal of Toxicologic Pathology 26 (suppl) 30-30, 2013.
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P-24 A 13-week Repeated Dose Study of 3-MCPD Esters in Rats.
Saeko ONAMI1), Young-Man CHO1), Takeshi TOYODA1), Midori YOSHIDA1), Akiyoshi NISHIKAWA2), Kumiko OGAWA1)
1)Pathology, National Institute of Health Sciences, 2)Biological Safety Research Center, National Institute of Health Sciences
Journal of Toxicologic Pathology 26 (suppl) 30-30, 2013.
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P-25 A 13-Week Repeated Dose Toxicity Study of Glycidol Fatty Acid Esters in F344 Rats
Takeshi TOYODA1), Young-Man CHO1), Saeko ONAMI1), Yasuko MIZUTA1), Jun-ichi AKAGI1), Isamu SUZUKI1), Akiyoshi NISHIKAWA2), Kumiko OGAWA1)
1)Div. Pathol., Natl. Inst. Health Sci., 2)Biol. Safety Res. Ctr., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 26 (suppl) 31-31, 2013.
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P-26 Dose Effect Relationship between Co-exposed Phthalate Esters on the Liver and Male Genital System after 90 Days Repeated Oral Administration in Rats
Kazuhiko SUZUKI1), Eriko TANIAI2),3), Reiko MORITA2),3), Atsunori YAFUNE2),3), Kunitoshi MITSUMORI4), Makoto SHIBUTANI2)
1)Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 2)Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3)Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 4)Food Safety Commission
Journal of Toxicologic Pathology 26 (suppl) 31-31, 2013.
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P-27 90-day Repeated Dose Toxicity and Genotoxicity Tests of Coptis chinensis in F344 Rats
Myoung Jun Kim1), Yong-Hoon Lee1), Duyeol Kim1), Sun Hee Park1), Hye-Yeong Lee1), Mi-Young Lee1), Mi Ju Lee1), Beom Seok Han2), Min Kwon2), Woo Chan Sohn3), Ji Hyeon Seok4), Jong Kwon Lee4), Jayoung Jeong4), Jin Seok Kang5), Jongkoo Kang1),6)
1)Biotoxtech, 2)Hoseo University Biomedical Laboratory Science, 3)Asan Medical Center, 4)KFDA, 5)NSU, 6)CBNU
Journal of Toxicologic Pathology 26 (suppl) 32-32, 2013.
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P-28 Historical Data on Neuropathological Examination in Acute and Repeated Dose Oral Neurotoxicity Study of Rats
Katsumi SOMA1), Naofumi TAKAHASHI1), Yuko SHIMADA1), Aya KOYAMA1), Maki KUWAHARA1), Yutaka KOMATSU1), Hideaki FUJIE1), Atsuko MOTOMURA1), Yasufumi SHUTOH1), Toshinori YOSHIDA1), Nobuaki NAKASHIMA1), Hiroaki Aoyama1), Takanori HARADA1)
1)The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 26 (suppl) 32-32, 2013.
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P-29 Ultrastructural Analysis of Demyelination and Remyelination Induced by Cuprizone in Mice
Ryuichi NAKAMURA, Tomonari NISHIMURA, Taehito OCHIAI, Shuichi KODA, Hiroyuki OGASAWARA
Asubio Pharma Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 33-33, 2013.
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P-30 Effect of Glycidol on Adult Neurogenesis in the Hippocampal Dentate Gyrus after 28 Days Repeated Administration in Rats
Hirotoshi AKANE1), Fumiyo SAITO2), Ayako SHIRAKI1),3), Megu Itahashi1),3), Liyun WANG1), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agricul. Technol., 2)Chem. Eval. Res. Inst., Chem. Assess. Res. Centr., 3)Pathogen. Vet. Sci., United Grad. Sch. Vet. Sci., Gifu Univ.
Journal of Toxicologic Pathology 26 (suppl) 33-33, 2013.
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P-31 Similar Expression Change of Midline1 on Neuronal Stem/Progenitor Cells Between Developmental and Adult-stage Hypothyroidism in the Hippocampal Dentate Gyrus in Rats
Liyun Wang1), Ayako Shiraki1),2), Hirotoshi Akane1), Megu Itahashi1),2), Kazuhiko Suzuki1), Kunitoshi Mitsumori1), Makoto Shibutani1)
1)Labotatory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2)Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University
Journal of Toxicologic Pathology 26 (suppl) 34-34, 2013.
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P-32 Strain differences in pleural mesothelial cell reactions induced by TISMO fibers infused directly into the thoracic cavity.
Masanao YOKOHIRA1), Nozomi HASHIMOTO1), Yuko NAKANO1), Keiko YAMAKAWA1), Tatsushi INOUE1), Sosuke KISHI1), Fumiko NINOMIYA1), Kousuke SAOO2), Katsumi IMAIDA1)
1)Onco-pathology, Faculty of Medicine, Kagawa University, 2)Diagnostic Pathology, Kaisei General Hospital
Journal of Toxicologic Pathology 26 (suppl) 34-34, 2013.
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P-33 Effects of chronic inflammation by quartz on DHPN-induced lung carcinogenesis in F344 and Wistar-Hannover rats -strain difference studies-
Yuko NAKANO1), Masanao YOKOHIRA1), Nozomi HASHIMOTO1), Keiko YAMAKAWA1), Sosuke KISHI1), Fumiko NINOMIYA1), Kousuke SAOO1),2), Katsumi IMAIDA1)
1)Onco-pathology, Faculty of Medicine, Kagawa University, 2)Diagnostic Pathology, Kaisei General Hospital
Journal of Toxicologic Pathology 26 (suppl) 35-35, 2013.
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P-34 Mouse Colon Cancer Model Using Benzo[a]pyrene and Dextran Sulfate Sodium： Strain Difference in Tumor Incidence
Jiro SONODA1), Yoshikazu TAKETA1), Atsushi HAKURA1), Naoki KOYAMA1), Satoru HOSOKAWA1), Yuki SEKI1), Akira INOMATA1), Kyoko NAKANO-ITO1), Etsuko OHTA1), Aya GOTO1), Kazuhiro HAYAKAWA2), Shoji ASAKURA1), Kazuo TSUKIDATE1)
1)Tsukuba Drug Safety, Global Drug Safety, Eisai Co.,Ltd., 2)Preclinical Safety Research Laboratories, Kawashima Division, Sunplanet Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 35-35, 2013.
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P-35 Examination of Formation and Development of Ovarian Follicles among the Different Strains of Rats
Maki KUWAHARA1), Yuko SHIMADA1), Katsumi SOMA1), Naofumi TAKAHASHI1), Aya KOYAMA1), Yuko CHIBA1), Masayuki ARAKI1), Toshinori YOSHIDA1), Nobuaki NAKASHIMA1), Hiroaki AOYAMA1), Takanori HARADA1)
1)The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 26 (suppl) 36-36, 2013.
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P-36 Spontaneous Megakaryocytic Hypoplasia in a SD Rat
Tomoaki TOCHITANI, Hirofumi OKAMURA, Kaoru TOYOSAWA, Izumi MATSUMOTO, Mami KOUCHI, Juki KIMURA, Hitoshi FUNABASHI
Safety Research Laboratories, Dainippon Sumitomo Pharma Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 36-36, 2013.
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P-37 Th2-based host immune response promote the development of cryoglobulinemia in mice infected with Capillaria hepatica
Moe YAMADA1), Naoyuki AIHARA2), Akane KASHIMURA2), Junichi KAMIIE2), Kinji SHIROTA1)
1)Research Institute of Biosciences, 2)Lab. Vet. Pathol, Azabu Univ.
Journal of Toxicologic Pathology 26 (suppl) 37-37, 2013.
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P-38 A Four-week Repeated Study of Intravenous Toxicity of Recombinant Human Interleukin-2 in Sprague-Dawley Rats
Mi Ju Lee1), Sun Hee Park1), Myoung Jun Kim1), Hye-Jin Kim4), Yinghua Li1), Kyeoung-Nam Ko1), Duyeol Kim1), Yong-Hoon Lee1), Sun-Hee Kim1), Ho-Song Jang1), Yeongjun Baik2), Sunghee Lee2), Jin Seok Kang3), Jong-Koo Kang4)
1)Biotoxtech, 2)BMI Korea, 3)NSU, 4)CBNU
Journal of Toxicologic Pathology 26 (suppl) 37-37, 2013.
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P-39 Spontaneous Thymoma Observed in Wistar Han rats
Hijiri Iwata1),2), Klaus Weber1),2), Susan Gaehle1), Takayuki Anzai1), Ciriaco Maraschiello1), Wendy Henderson1)
1)Harlan Laboratories Ltd, 2)Ana Path GmbH.
Journal of Toxicologic Pathology 26 (suppl) 38-38, 2013.
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P-40 Ophthalmologic and Histopathological Examinations in the Aged Buphthalmic Rabbits
Yulin YAO, Osamu KATSUTA
Santen Pharmaceutical Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 38-38, 2013.
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P-41 Histopathological Analysis of the Ocular Lesions in Experimental Autoimmune Uveoretinitis in C57BL/6 Mice
Yutaka NAKAHARA, Naomi SAITOH, Toshirou KASUGA, Kanae KURODA, Kiyoshi KUSHIMA, Takahisa NOTO, Shunji NAKATSUJI, Masahiro MATSUMOTO
Drug Safety Research Labs, Astellas Pharma Inc.
Journal of Toxicologic Pathology 26 (suppl) 39-39, 2013.
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P-42 Spontaneous Immune-Mediated Glomerulonephritis in a Hatano Rat
Kyohei YASUNO1), Ryosuke KOBAYASHI1), Haruka SAKASHITA1), Saori ARAKI1), Mariko SHIROTA2), Junichi KAMIIE3), Kinji SHIROTA1),3)
1)Research Institute of Biosciences, 2)Lab. Comp. Toxicol., 3)Lab. Vet. Pathol., Azabu Univ.
Journal of Toxicologic Pathology 26 (suppl) 39-39, 2013.
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P-43 Mesangial erythrophagocytosis in renal glomeruli in aged B6C3F1 mice
Ryosuke KOBAYASHI, Naoaki YAMADA, Hiroko KOKOSHIMA, Takuya DOI, Junko SATO, Yumi WAKO, Minoru TSUCHITANI
Pathology Department, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 26 (suppl) 40-40, 2013.
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P-44 Cytoplasmic Vacuoles Detected in the NNK-induced Lung Tumors of A/J Mice
Keiko YAMAKAWA, Sosuke KISHI, Fumiko NINOMIYA, Masanao YOKOHIRA, Yuko NAKANO, Katsumi IMAIDA
Onco-Pathology, Faculty of Medicine, Kagawa University
Journal of Toxicologic Pathology 26 (suppl) 40-40, 2013.
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P-45 Mesothelioma of Thoracic and Abdominal Cavity in a B6C3F1 Mouse
Masayo HOSOI1), Atushi SHIGA1), Kazushige HASEGAWA1), Rumiko MIYAJIMA1), Yoshihide UEDA1), Yasufumi OTA1), Shigeaki TAKAMI1), Isao NARAMA1)
1)BSRC
Journal of Toxicologic Pathology 26 (suppl) 41-41, 2013.
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P-46 The State of The Occurrence of Amyloidosis and The Correlation between Amyloidosis and Excoriation in Carcinogenicity Studies in ICR Mice
Natsumi SHIMOYAMA, Yuko YAMAGUCHI, Kaori NISHIHARA, Tomomi NAKAZAWA, Kazutoshi TAMURA, Toru HOSHIYA
BOZO Research Center Inc.
Journal of Toxicologic Pathology 26 (suppl) 41-41, 2013.
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P-47 Analysis of Cytokeratin8/18 and Cytokeratin 19 Expression in Mouse Liver Tumors
Masahiko KUSHIDA1),2), Tyler J.PEAT1), James E.KLAUNIG1)
1)Dep. Environmental Health, School of Public Health in Bloomington, Indiana University, 2)Environmental Health Science Lab., Sumitomo Chemical
Journal of Toxicologic Pathology 26 (suppl) 42-42, 2013.
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P-48 Study on Modification of Liver Tumor Promotion in Rats Subjected to Co-Administration of Phenobarbital and Orphenadrine
Reiko MORITA1),2), Atsunori YAFUNE1),2), Hirotoshi AKANE1), Megu ITAHASHI1),2), Ayako SHIRAKI1),2), Kazuhiko Suzuki3), Makoto SHIBUTANI1), Kunitoshi MITSUMORI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agricul. And Technol., 2)Pathogen. Vet. Sci., United Grad. Sch. Vet. Sci., Gifu University, 3)Lab. Vet. Toxicol., Tokyo Univ. Agricul. And Technol.
Journal of Toxicologic Pathology 26 (suppl) 42-42, 2013.
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P-49 The role of gap junctional intercellular communication on apoptotic signaling in rat hepatocellular carcinoma cells
Aya NAIKI-ITO, Makoto ASAMOTO, Hiroyuki KATO, Tomoyuki SHIRAI, Satoru TAKAHASHI
Dept. of Exp. Pathol. and Tumor Biol., Nagoya City Univ. Grad. Sch. of Med. Sci.
Journal of Toxicologic Pathology 26 (suppl) 43-43, 2013.
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P-50 Differences in nephrotoxicity according to polymixin B administration route
Atsuko YUASA, Yuko MARUYAMA, Naohisa UMEYA, Takanori HIOKI, Hiroshi SATOH
Safety Evaluation Center, Fujifilm Corporation
Journal of Toxicologic Pathology 26 (suppl) 43-43, 2013.
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P-51 Histopathological Evaluation of Temporal Changes in Renal Toxicity of Colistin Sodium Methanesulfonate in Mice
Kyohei AGO1), Yasushi KURATA1), Fumi ITO1), Yuji KAWAMURA1), Masahiro NOMOTO2), Toshiyuki TSUCHIYA1), Kazuyuki HIRATSUKA1), Kokichi SUZUKI3)
1)Meiji Seika Pharma Co.,Ltd., Pharmaceutical Research Center Toxicology laboratory, 2)Meiji Seika Pharma Co.,Ltd., Pharmaceutical Research Center Pharmacokinetics laboratory, 3)Meiji Seika Pharma Co.,Ltd., Pharmaceutical Research Center
Journal of Toxicologic Pathology 26 (suppl) 44-44, 2013.
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P-52 Effects of p53 knockout on OTA-induced in vivo mutagenicity, apoptosis, and karyomegaly in the kidney, a carcinogenic site
Daisuke HIBI1), Aki KIJIMA1), Yuta SUZUKI1), Meilan JIN1), Yuji ISHII1), Yoshiko KONISHI2), Kumiko Ogawa1), Takashi UMEMURA1)
1)Divisions of Pathology, National Institute of Health Sciences, 2)Divisions of Microbiology, National Institute of Health Sciences
Journal of Toxicologic Pathology 26 (suppl) 44-44, 2013.
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P-53 Mechanisms mediating ocharatoxin A-induced deletion mutations in the kidneys of gpt delta rats
Ken KURODA1), Maiko WATANABE2), Daisuke HIBI1), Yuji ISHII1), Shinji TAKASU1), Aki KIJIMA1), Kohei MATSUSHITA1), Takehiko NOHMI3), Yoshiko SUGITA-KONISHI2), Takashi UMEMURA1)
1)Division of Pathology, NIHS, 2)Division of Microbiology, NIHS, 3)Biological Safety Research Center, NIHS
Journal of Toxicologic Pathology 26 (suppl) 45-45, 2013.
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P-54 Histopathological Examination on Hyaline droplets in the Urinary Bladder of Type 2 Diabetes Model db/db Mice
Azusa KOBAYASHI, Kazufumi KAWASAKO, Takafumi OSHIKATA, Koshirou KATOKU, Mikio MITSUISHI, Takeshi KANNO, Masao HAMAMURA
Pathology Department, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 26 (suppl) 45-45, 2013.
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P-55 Examination of in vivo mutagenicity of rat bladder carcinogen DMA(V)
Masaki FUJIOKA, Min WEI, Shotaro YAMANO, Kyoko OKABE, Satoki FUKUNAGA, Xiaoli XIE, Hideki WANIBUCHI
Department of Pathology, Osaka city university graduate school of Medicine
Journal of Toxicologic Pathology 26 (suppl) 46-46, 2013.
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P-56 Medium-term Urinary Bladder Carcinogenesis Bioassay of Ethyl tertiary-Butyl Ether (ETBE) in Rats
Norio IMAI1), Akihiro HAGIWARA1), Yuko Doi1), Mayuko SUGURO1), Seiko TAMANO1), Kasuke NAGANO2), Shoji FUKUSHIMA3)
1)DIMS Inst. Med. Sci., 2)Nagano Toxicologic-Pathology Consulting, 3)Japan Bioassay Research Center, JISHA
Journal of Toxicologic Pathology 26 (suppl) 46-46, 2013.
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P-57 Modifying Effects of High Fat Diet during a Juvenile Stage on DMBA-induced Mammary Carcinogenesis in Rats
Toshio IMAI, Naoaki UCHIYA, Mami Takahashi
Central Anim. Div., Natl. Cancer Center Res. Inst.
Journal of Toxicologic Pathology 26 (suppl) 47-47, 2013.
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P-58 Modifying Effect of Glycidol Fatty Acid Esters on Mammary Carcinogenesis in SD Rats
Young-Man CHO1), Yasuko MIZUTA1), Takeshi TOYODA1), Saeko ONAMI1), Junichi AKAGI1), Isamu SUZUKI1), Akiyoshi NISHIKAWA2), Kumiko OGAWA1)
1)Div. Pathol., Natl. Inst. Health Sci., 2)Biol. Safety Res. Center, Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 26 (suppl) 47-47, 2013.
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P-59 Effects of Combined Treatments of DHPN and DMBA on Mammary Carcinogenesis in F344 Female Rats
Sosuke KISHI1), Masanao YOKOHIRA1), Yuko NAKANO1), Keiko YAMAKAWA1), Fumiko NINOMIYA1), Kousuke SAOO2), Katsumi IMAIDA1)
1)Onco-pathology, Faculty of Medecine, Kagawa University, 2)Daignostic Pathology, Kaisei General Hospital
Journal of Toxicologic Pathology 26 (suppl) 48-48, 2013.
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P-60 The Modifying Effects of Hyperbaric Oxygen in Mouse Skin Carcinogenesis
Hiroshi DOGUCHI1), Reika TAKAMATSU1), Ryosuke KATAYAMA2), Masanao SAIO1), Naoki YOSHIMI1)
1)Univ. of the Ryukyus, 2)Musashino Immunity Inst.
Journal of Toxicologic Pathology 26 (suppl) 48-48, 2013.
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P-61 Cellular Distribution of Proliferation, Apoptosis, and Cell Cycle-related Markers at the Early Stage of Tumor Promotion in Rat Two-stage Carcinogenesis Models
Eriko TANIAI1),2), Atsunori YAFUNE1),2), Reiko MORITA1),2), Megu ITAHASHI1),2), Kazuhiko SUZUKI3), Kunitoshi MITSUMORI4), Makoto SHIBUTANI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agricul. Technol., 2)Pathog. Vet. Sci., United Grad. Sch. Vet. Sci., Gifu Univ., 3)Lab. Vet. Toxicol., Tokyo Univ. Agricul. Technol., 4)Food Safety Commission., Cabinet Office.
Journal of Toxicologic Pathology 26 (suppl) 49-49, 2013.
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P-62 Expression Characteristics of Cell Cycle-related Proteins at the Early Stage of Tumor Promotion in Rat Two-stage Carcinogenesis Models
Atsunori YAFUNE1),2), Eriko TANIAI1),2), Reiko MORITA1),2), Hirotoshi AKANE1), Liyun WANG1), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI3), Makoto SHIBUTANI1)
1)Lab. Vet. Pathol., Tokyo Univ. Agricul. And Technol., 2)Pathogen. Vet. Sci., United Grad. Sch. Vet. Sci., Gifu University, 3)Food Safety Com.
Journal of Toxicologic Pathology 26 (suppl) 49-49, 2013.
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P-64 Activation of the Canonical Wnt Signaling Maintains Normal and Neoplastic Gastric Epithelial Cells in Undifferentiated and Proliferative States
Akihiro HIRATA1), Yasuhiro YAMADA2), Hiroyuki TOMITA3), Toshiya KUNO3), Atsuko MURAI4), Tetsuya TSUKAMOTO5), Masami YAMAMOTO5), Akira HARA3)
1)Div. Animal Experiment, Life Sci. Res. Ctr., Gifu Univ., 2)Ctr. for iPS Cell Res. and Application (CiRA), Kyoto Univ., 3)Dept. Tumor Pathol., Gifu Univ. Graduate Sch. Med., 4)Pathogenic Vet. Sci., Gifu Univ. United Graduate Sch. Vet. Sci., 5)Dept. Diagonostic Pathol., Sch. Med., Fujita Health Univ., 5)Div. Physiol. Pathol., Sch. Vet. Nurs. Tech., Fac. Vet. Sci., Nippon Vet. Life Sci. Univ.
Journal of Toxicologic Pathology 26 (suppl) 50-50, 2013.
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P-65 Soluble VEGFR-3 Decoy but not SATB1 siRNA Suppresses Metastasis in a Highly Metastatic Mouse Mammary Cancer Model
Masa-Aki SHIBATA1), Junji MORIMOTO2), Eiko SHIBATA3), Shigekazu FUJIOKA1), Mariko HARADA-SHIBA3)
1)Lab. Anat & Histopathol., Osaka Health Sci. Univ., 2)Lab. Animal Center, Osaka Med. Coll., 3)Dept. Mol. Innovation in Lipidol., Natl. Cerebral & Cardiovasc. Center Res. Inst.
Journal of Toxicologic Pathology 26 (suppl) 50-50, 2013.
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P-66 Autophagy signalings in human breast cancer cell MCF-7 were up-regulated by allil isothiocyanate (AITC) and induced the cell death.
Makoto ASAMOTO, Aya-Naiki IT, Satoru TAKAHASHI
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
Journal of Toxicologic Pathology 26 (suppl) 51-51, 2013.
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P-67 Epithelial-mesenchymal Transition in Mice Bearing Human Lung Cancer Cell Lines
Yoshika YAMAKAWA1), Takahisa NOTO1), Mihoko ONO1), Kenjiro TSUBOTA1), Masamichi MORI2), Yoko UENO2), Shunji NAKATSUJI1), Masahiro MATSUMOTO1)
1)Toxicologic Pathology, Drug Safety Research Labs., Astellas Pharma Inc., 2)Oncology, Pharmacology Research Labs., Astellas Pharma Inc.
Journal of Toxicologic Pathology 26 (suppl) 51-51, 2013.
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P-68 Different Histopathological Dermal Changes Exposed Transcutaneously to Two Nano-particle Sizes of Platinum in Rats
Fumiaki KUMAGAI1), Kenji USUMI1), Hideki MARUMO1), Kazunori KONNO1), Yasuo YOSHIOKA2), Yasuo TSUTSUMI2), Yoshiaki SAITO1), Makiko KUWAGATA1)
1)Division of Toxicology, Hatano Research Institute, Food and Drug Safety Center., 2)Graduate School of Pharmaceutical Sciences, Osaka University.
Journal of Toxicologic Pathology 26 (suppl) 52-52, 2013.
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P-69 A 13-Week Repeated Dose Study of Nanoclay Consisting Mainly of Montmorillonite in the Diet to F344 Rats
Isamu SUZUKI1), Saeko ONAMI1), Young-Man CHO1), Takeshi TOYODA1), Jun-ichi AKAGI1), Yasuko MIZUTA1), Akiyoshi NISHIKAWA2), Kumiko OGAWA1)
1)Division of Pathology, National Institute of Health Science, 2)Biological Safety Research Center, National Institute of Health Science
Journal of Toxicologic Pathology 26 (suppl) 52-52, 2013.
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P-70 Effects of Gamma-oryzanol or Glycerol on the Pulmonary Changes Due to the Intratracheally Instilled Magnetite Nanoparticles in Fischer 344 Rats
Yukie TADA1), Norio YANO1), Hiroshi TAKAHASHI1), Katsuhiro YUZAWA1), Hiroshi ANDO1), Yoshikazu KUBO1), Akemichi NAGASAWA1), Akiko INOMATA1), Akio OGATA1), Dai NAKAE1),2)
1)Tokyo Metropolitan Institute of Public Health, 2)Tokyo University of Agriculture
Journal of Toxicologic Pathology 26 (suppl) 53-53, 2013.
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P-71 Enhanced Cellular Uptake and Cytotoxicity of Curcumin-Loaded PLGA Conjugated with Anti-P-glycoprotein Ab in Drug Resistance Cancer Cells
Wanisa PUNFA1), Supachai YODKEEREE1), Pornsiri PITCHAKARN1), Chadarat AMPASAVATE2), Pornngarm LIMTRAKUL1)
1)Department of Biochemistry, Faculty of Medicine, Chiang Mai University, 2)Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University
Journal of Toxicologic Pathology 26 (suppl) 53-53, 2013.
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P-72 Effects of Grape Skin Extract on the Glandular Epithelial Cells of Parotid Glands in Rats
Kaoru INOUE1), Miwa TAKAHASHI1), Saori MATSUO1), Kei TAMURA1), Tomomi MORIKAWA1), Kumiko OGAWA1), Midori YOSHIDA1)
1)Div. Pathol., Natl. Inst. Health Sci.
Journal of Toxicologic Pathology 26 (suppl) 54-54, 2013.
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P-73 90-Day Repeated Dose Rat Toxicity Studies of Gum Ghatti
Shim-mo HAYASHI1), Jeffrey DAVIS2), Glenda MOSER2), Susan BORGHOFF2), Dipak GIRI2), Robert MARONPOT3)
1)San-Ei Gen F.F.I., Inc., 2)Integrated Laboratory Systems, Inc., 3)Maronpot Consulting LLC
Journal of Toxicologic Pathology 26 (suppl) 54-54, 2013.
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P-74 Historical Control Data from 104-Weeks Study in RccHan(TM)：WIST Rats
Mika NAGAIKE1), Seiichiro TSUCHIYA1), Kosei INUI1)
1)Safety Science Laboratory, Central Research Institute, Ishihara Sangyo Kaisha Ltd.
Journal of Toxicologic Pathology 26 (suppl) 55-55, 2013.
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P-75 Inhalation Carcinogenicity of 1, 1, 1-Trichloroethane in Rats and Mie
Taku KATAGIRI1), Kenji TAKANOBU1), Hideki SENOH1), Yumi UMEDA1), Makoto Ohnishi1), Kasuke Nagano2), Shigetoshi AISO1), Shoji FUKUSHIMA1)
1)Japan Bioassay Research Center (JBRC), Japan Industrial Safety and Health Association (JISHA), 2)Nagano Toxicologic-Pathologic Consulting
Journal of Toxicologic Pathology 26 (suppl) 55-55, 2013.
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P-76 Implantation Study of Endovascular Embolization Coil for Cerebral Aneurysm： Comparison of Histological Preparation Methods
Atsushi ISOBE1), Hisako TERAO1), Ryouhei ASOU1), Junko SOUBA1), Masako TASAKI1), Tomoki INOUE1), Atsushi SAKAOKA1), Masayoshi KANISAWA2), Hitomi HAGIWARA1)
1)Evaluation Center, R&D Headquarters, TERUMO Corporation, 2)Yokohama City University School of Medicine
Journal of Toxicologic Pathology 26 (suppl) 56-56, 2013.
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P-77 Implantation Study of Endovascular Embolization Coil for Cerebral Aneurysm： Recommendations for Successful Long-Term Implantation Test
Ryouhei ASOU1), Hisako TERAO1), Junko SOUBA1), Atsushi ISOBE1), Masako TASAKI1), Tomoki INOUE1), Atsushi SAKAOKA1), Masayoshi KANISAWA2), Hitomi HAGIWARA1)
1)Evaluation Center, R&D Headquarters, TERUMO Corporation, 2)Yokohama City University School of Medicine
Journal of Toxicologic Pathology 26 (suppl) 56-56, 2013.
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P-78 The effect of the repeated inhalation (isoflurane) or intraperitoneal anesthesia (mixture of medetomidine, midazolam and butorphanol) for 4 weeks in rats.
Yasuko HASEGAWA-BABA1), Hisayo KUBOTA1), Kenichi KOBAYASHI1), Midori YOSHIDA2), Muneyuki MIYAGAWA1)
1)National Institute of Occupational Safety and Health, 2)National Institute of Health Sciences
Journal of Toxicologic Pathology 26 (suppl) 57-57, 2013.
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P-79 Deliberations on Humane Endpoints for Carcinogenicity Studies
Yuko SHIMADA, Katsumi SOMA, Aya KOYAMA, Naofumi TAKAHASHI, Maki KUWAHARA, Toshinori YOSHIDA, Hisao KAWAKATSU, Yoshio TAKIZAWA, Makio TAKEDA, Ken TAKAHASHI, Yasufumi SHUTOH, Hideo UEDA, Nobuaki NAKASHIMA, Hiroaki AOYAMA, Takanori HARADA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 26 (suppl) 57-57, 2013.
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P-80 Investigation of Drug Induced Osteocyte Toxicity Using a Bone Organ Culture Method
Yasuhiro KOJIMA, Aisuke NII, Akio KAWAKAMI, Dai MURAMATSU, Yuka MINAMISAWA, Ikue KITAZAWA, Miki SUEHIRO, Shinichi NAKAJIMA
Medicinal Safety & Phamacokinetics Dept., Central Research Lab., Seikagaku Co.
Journal of Toxicologic Pathology 26 (suppl) 58-58, 2013.
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P-81 The Effect of Cathepsin K Inhibitor and Bisphosphonate on Bone Tissue in Rats
Yusuke KAGAWA1), Kei KUBOTA1), Yuka MINAMISAWA1), Ikue KITAZAWA1), Dai MURAMATSU1), Kyoko IMAI2), Shinichi NAKAJIMA1), Aisuke NII1)
1)Medicinal Safety & Phamacokinetics Dept., 2)Pharmacology Dept., Central Research Lab., Seikagaku Co.
Journal of Toxicologic Pathology 26 (suppl) 58-58, 2013.
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P-82 Compound X-induced irreversible skeletal muscle injury
Tomoe TANIMOTO1), Jun HIRAO1), Takashi YAMAGUCHI1), Mayumi GOTO1), Kazumi ITO1), Noriyo NIINO1), Kiyonori KAI1), Kazuhiko MORI1), Noriko MASUBUCHI2), Munehiro TERANISHI1), Wataru TAKASAKI1)
1)Medicinal Safety Research Laboratories, Daiichi Sankyo Co.,Ltd., 2)Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi Sankyo Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 59-59, 2013.
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P-83 Immunohistochemistry with Anti-thyroid Transcriptional Factor-1 for Thyroid Proliferative Lesion in Rats； Usefulness for Tumor Diagnosis
Hikaru MITORI1), Mihoko ONO1), Yuichi MURAKAMI1), Ayano TAKEUCHI1), Tetsuya IDE1), Shunji NAKATSUJI1), Yuji OISHI1), Masahiro MATSUMOTO1)
1)Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc.
Journal of Toxicologic Pathology 26 (suppl) 59-59, 2013.
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P-84 A Spontaneous Epithelial-Myoepithelial Carcinoma of the Submandibular Gland in a Sprague-Dawley Rat
The Japanese Society of Toxicologic Pathology
The Japanese Society of Toxicologic Pathology
Journal of Toxicologic Pathology 26 (suppl) 60-60, 2013.
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P-85 Ectopic Tissue of Forestomach Consisting of a mixed tissue of Glandular Stomach, Small Intestine and Exocrine Pancreas in a Rat
Yuki KATO, Emi KASHIWAGI, Koichi MASUNO, Kae FUJISAWA, Shuuichi MATSUSHIMA, Nobuo TAKASU
Developmental Research Laboratories, Shionogi & Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 60-60, 2013.
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P-86 Pathological Examination of Adenocarcinoma Originating from Pancreatic or Biliary Duct in a SD Rat
SHUJI TAKEDA, KAORI MIYATA, TOMOYA YAMADA, MASAHIKO KUSHIDA, KEIKO OGATA, HIROKO KIKUMOTO, YU OKUDA, SATOSHI KAWAMURA
Environmental Health Science Laboratory, Sumitomo Chem Co.,Ltd.
Journal of Toxicologic Pathology 26 (suppl) 61-61, 2013.
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P-87 Morphological Diversity of Endometrial Stromal Sarcoma in Rats
Shino KUMABE1), Junko SATO1), Yuki TOMONARI1), Satomi HASHIMOTO1), Miwa TAKAHASHI2), Midori YOSHIDA2), Takuya DOI1), Yumi WAKO1), Minoru TSUCHITANI1)
1)Pathology Department, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation, 2)Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 26 (suppl) 61-61, 2013.
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P-88 A Case of Metastatic Adrenocortical Carcinoma Diagnosed by Steroidogenic Factor-1 in a Sprague-Dawley Rat
Yuichi TAKAI, Tomoya SANO, Takeshi WATANABE, Ryo FUKUDA
Takeda Pharmaceutical Company Ltd. Drug Safety Research Laboratories
Journal of Toxicologic Pathology 26 (suppl) 62-62, 2013.
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P-89 Histopathological Changes in Fetal and Neonatal Rats Exposed to Busulfan
Tsubasa SAITO, Ryo ANDO, Toko OHIRA, Shinichiro IKEZAKI, Toru HOSHIYA, Kazutoshi TAMURA
Pathology Division, Gotemba Laboratories, Bozo Research Center Inc.
Journal of Toxicologic Pathology 26 (suppl) 62-62, 2013.
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P-90 Immunohistochemical and Comprehensive Gene Expression Analyses of Different Clonal Cell Lines (MT-8 and MT-9) from Rat Malignant Fibrous Histiocytoma (MFH)
Takashi KOTERA1), Chisa ICHIKAWA1), Anusha TENNAKOON1),2), Takeshi IZAWA1), Mitsuru KUWAMURA1), Seishi OCHI2), Joji YAMATE1)
1)Osaka prefectural university, 2)Nippon Shinyaku
Journal of Toxicologic Pathology 26 (suppl) 63-63, 2013.
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P-91 Proposed Change to Rodent Carcinogenicity Testing of Pharmaceuticals in ICH
Mizuho NONAKA1), Kumiko OGAWA2), Hiroshi ONODERA1), Dai NAKAE3), Akiyoshi NISHIKAWA2)
1)PMDA, 2)NIHS, 3)Tokyo Metropolitan Inst. Public Health
Journal of Toxicologic Pathology 26 (suppl) 63-63, 2013.
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