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Alternatives to Animal Testing and Experimentation 15巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN（オンライン）
2185-4726
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開始頁
PL Basics and Practice of Alternatives to Animal Experiments
Yuji Yoshiyama
Division of Community Pharmacy Center for Clinical Pharmacy and Clinical Sciences, Kitasato Uninersity School of Pharmacy
Alternatives to Animal Testing and Experimentation 15 (suppl) 187-187, 2010.
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SL-1 Data science on validation studies conducted by JSAAE
Takashi Omori
Doshisha University Faculty of Culture and Information Science
Alternatives to Animal Testing and Experimentation 15 (suppl) 188-188, 2010.
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SL-2 Recent topics on chronopharmaceutics focused on molecular clock
Shigehiro Ohdo
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University
Alternatives to Animal Testing and Experimentation 15 (suppl) 189-189, 2010.
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S1-1 Situation at the Ministry of the Environment for the Amendment of the Animal Protection Law
Yoshihiro Hayashi
Faculty of Agriculture, Tokyo University of Agriculture
Alternatives to Animal Testing and Experimentation 15 (suppl) 190-190, 2010.
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S1-2 Perspectives on amendment of the Animal Law Laboratory animals (1): To implement science-based laboratory animal welfare
Naoko Kagiyama
Hokkaido University Graduate School of Veterinary Medicine
Alternatives to Animal Testing and Experimentation 15 (suppl) 191-191, 2010.
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S1-3 Trend of International Advancement of Alternative Program Comparison with Japanese Legislation and Guidelines
Tsutomu Miki Kurosawa, DVM, M.Phil, Ph.D, DVCS, DJCLAM
Osaka University Graduate School of Medicine Department of Laboratory Animal Medicine
Alternatives to Animal Testing and Experimentation 15 (suppl) 192-192, 2010.
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S1-4 Are Animal Experiments the Ultimate Cruelty to Animals?
Koichi Aoki
The Japanese Coalition for Animal Welfare
Alternatives to Animal Testing and Experimentation 15 (suppl) 193-193, 2010.
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S1-5 Where Does Humane Science Should Head to?
Hiromi Kamekura
NPO Japan Anti-Vivisection Association
Alternatives to Animal Testing and Experimentation 15 (suppl) 194-194, 2010.
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S2-1 Electrochemical Detachment of Cells and Cell Sheets for Engineering Cellular Tissues
Junji Fukuda, Hiroaki Suzuki
Graduate School of Pure and Applied Sciences, University of Tsukuba
Alternatives to Animal Testing and Experimentation 15 (suppl) 195-195, 2010.
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S2-2 Microfabrication of co-culture systems
Nishizawa M.1, 2, Kaji H.1, 2, Nagamine K.1, 2, Kanzaki M.2, 3
1Department of Engineering, Tohoku University, 2JST-CREST, 3Department of Medical Engineering, Tohoku University
Alternatives to Animal Testing and Experimentation 15 (suppl) 196-196, 2010.
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S2-3 Perfusion Culture Microchamber Array Chip for High Throughput Drug Dose Response Assay
Toshiyuki Kanamori, Shinji Sugiura, Koji Hattori, Kimio Sumaru
National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 15 (suppl) 197-197, 2010.
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S2-4 Wearable Bio/Chemical Sensor with Soft-MEMS Techniques
Kohji Mitsubayashi
Institute of Biomaterials & Bioengineering, Tokyo Medical and Dental University
Alternatives to Animal Testing and Experimentation 15 (suppl) 198-198, 2010.
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S3-1 Suggestion of an ideal evaluation system using a corneal epithelial cell from the experience of CS-088 antiglaucoma ophthalmic solution
Takayuki Kikuchi
Formulation Technology Research Laboratories, Daiichi Sankyo Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 199-199, 2010.
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S3-2 Development of a human cornea model utilizing a collagen vitrigel membrane as a scaffold and its advantages
Toshiaki Takezawa1, Hiroyuki Yamaguchi1, 2
1National Institute of Agrobiological Sciences, 2Kanto Chemical Co.Inc
Alternatives to Animal Testing and Experimentation 15 (suppl) 200-200, 2010.
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S3-3 Induction of drug-metabolizing enzymes by layered co-culture of a human liver cell line
Akiyoshi Taniguchi1, 2, Maki Ohno1
1Biomaterials Center, National Institute for Materials Science, 2Faculty of Science and Engineering, Waseda University
Alternatives to Animal Testing and Experimentation 15 (suppl) 201-201, 2010.
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S3-4 Usability of hepatocyte spheroid culture on Cell-able in DMPK research: results with human and rat primary hepatocytes
Shin Enosawa
Division for Advanced Medical Sciences, Clinical Research Center, National Center for Child Health and Development
Alternatives to Animal Testing and Experimentation 15 (suppl) 202-202, 2010.
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S3-5 Development of culture system for induction of hepatic stem cells from human fetal hepatocytes
Taku Matsushita
Lab.of Biomedical Eng., Dept.of Applied Life Science, Sojo University
Alternatives to Animal Testing and Experimentation 15 (suppl) 203-203, 2010.
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S3-6 Application of human stem cells to the safety/toxicity study of drug candidates---Road to the guideline plan making
Seiichi Ishida
National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 15 (suppl) 204-204, 2010.
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S4-1 Current status of the alternative to the skin irritation test method
Yuko Okamoto
KoseCorporation, Fundamental research laboratories
Alternatives to Animal Testing and Experimentation 15 (suppl) 205-205, 2010.
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S4-2 Cosmetic skin disorders-Focus of irritant contact dermatitis-
Masatoshi Ito1, Fukuyoshi Mori
1Toho University School of Medicine
Alternatives to Animal Testing and Experimentation 15 (suppl) 206-206, 2010.
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S4-3 In vivo Researches for Practical Use of Substituting Methods for Skin Irritation Studies
Yasushi Yamada
Nihon Bioresearch Inc
Alternatives to Animal Testing and Experimentation 15 (suppl) 207-207, 2010.
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S4-4 Validity of the EpiSkin(TM) test in Japan; Skin irritancies of cosmetic ingredients tested using EpiSkin(TM)
Shoichi Yahagi1, Miyuki Fujishiro1, Yukiko Izutsu1, Daisuke Yoshida1, Koji Kurihara2, Yuri Okano1, Hitoshi Masaki1
1Nikkol group Cosmos Technical Center Co., Ltd, 2Nikkol group Nikoderm Research Inc
Alternatives to Animal Testing and Experimentation 15 (suppl) 208-208, 2010.
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S4-5 Skin irritation test using LabCyte CORNEA-MODEL
Masakazu Katoh
Japan Tissue Engineering Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 209-209, 2010.
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S4-6 Approach to the current requirements for alternative method of skin irritation testing
Mariko Sugiyama
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 15 (suppl) 210-210, 2010.
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S5-L Chemical management policy and hazard assessment of chemical in Japan
Shinichi Jitsukuni
Chemical Safety Office, Chemical Management Policy Division, METI
Alternatives to Animal Testing and Experimentation 15 (suppl) 211-211, 2010.
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S5-1-1 Development of the reporter gene assay system using multicolor luciferase probes
Yoshihiro Nakajima1, Shigeaki Nishii2, Yoshihiro Ohmiya2
1National Institute of Advanced Industrial Science and Technology (AIST), 2Tsuruga Institute of Biotechnology, Toyobo Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 212-212, 2010.
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S5-2-1 A Cell Transformation Assay Using Bhas 42 Cells: A Proposal for Guideline and Development a High-Throughput Screening Assay
Kiyoshi Sasaki1, Dai Muramatsu1, Shoko Arai1, Nobuko Endou1, Sachiko Kuroda1, Kumiko Hayashi1, Ayako Sakai1, Shojiro Yamazaki1, Yeon-mi Lim1, Makoto Umeda1, Masanori Wada2, Noriho Tanaka1
1Hatano Research Institute, Food and Drug Safety Center, 2ABLE Corporation
Alternatives to Animal Testing and Experimentation 15 (suppl) 213-213, 2010.
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S5-2-2 Development of novel alternative tests for developmental toxicity-Reporter gene assays using mouse ES cells and improvement of rat whole embryo culture-
Noriyuki Suzuki1, Koichi Saito1, Masaharu Akita2
1Institution Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 2Kamakura Women's University
Alternatives to Animal Testing and Experimentation 15 (suppl) 214-214, 2010.
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S5-2-3 Immunotoxicity: Development of a reporter gene assay system using human cell lines
Setsuya Aiba, Rumiko Saito, Yutaka Kimura, Ikuko Numata, Toshiya Takahashi
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 15 (suppl) 215-215, 2010.
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IS-1 International Symposium for Alternatives to Animal Experimentation. At The 23rs JSAAE annual meeting.
Tsutomu Miki Kurosawa, DVM, M.PHIL, Ph.D, DVCS, DJCLAM
Division of Laboratory Animal Medicine, Osaka University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 15 (suppl) 216-216, 2010.
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IS-2 Comparison of flow cytometry (FCM) and immunohistochemistry (IHC) in non-radioisotopic murine LLNA using BrdU and the prevalidation of LLNA:BrdU FCM
Kyung-Min Lim1, Kyoung-Mi Jung1, Won-Hee Jang1, Bae-Hwan Kim2, Yong-Kyoung Lee3, Young Na Yum3, Soojung Sohn3
1Pharmaceutical Research Institute, Amorepacific CO R&D Center, 2Department of Public Health, Keimyung University, 3National Institute of Food and Drug Safety Evaluation/Korea Food and Drug Administration
Alternatives to Animal Testing and Experimentation 15 (suppl) 217-217, 2010.
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IS-3 Current Status of Alternative Study in China
He Zhengming
National Institute for the Control of Pharmaceutical and Biological Products
Alternatives to Animal Testing and Experimentation 15 (suppl) 218-218, 2010.
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IS-4 National Regulations and Standards of Laboratory Animal Welfare in China
Guo-jie YANG
Peking University Health Science Center
Alternatives to Animal Testing and Experimentation 15 (suppl) 219-219, 2010.
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IS-5 Current activities for enhancing development and establishment of alternatives to animal experiments in Korea: focusing on an example of bovine corneal opacity and permeability test
Yong Heo1, Yeon Mi Lim1, Joo Hee Han2, Seung Hyeok Seok2, Soon-Young Han3, Soo Jung Sohn3, Young Na Yum3
1Catholic University of Daegu, College of Natural Sciences, Dept.Occupational Health, 2Seoul National University, College of Veterinary Medicine, 3National Institute of Food and Drug Safety Evaluation/Korea Food and Drug Administration
Alternatives to Animal Testing and Experimentation 15 (suppl) 220-220, 2010.
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EL-1 Application of Cell-recognizable Matrix-engineering to Tissue Engineering and Regenerative Medicine. -Frontier of Immobilization of E-Cadhering
Toshihiro Akaike
Frontier Research Center, Tokyo Institute of Technology
Alternatives to Animal Testing and Experimentation 15 (suppl) 221-221, 2010.
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EL-2 State-of-the Art of Hepatic Generation from Stem Cells
Takahiro Ochiya
Section for Studies on Metastasis, National Cancer Center Research Institute
Alternatives to Animal Testing and Experimentation 15 (suppl) 222-222, 2010.
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M-1 Formation and Functional Evaluation of a Minimum Cell Mass for In Vitro Toxicity Tests
Kikuo Komori
Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 15 (suppl) 223-223, 2010.
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M-2 Establishment of chronopharmacokinetic evaluation system in vitro cultured cells: Molecular basis for rhythmic expression of CYP in serum-shocked HepG2 cells
Shigehiro Ohdo, Satoru Koyanagi, Naoya Matsunaga
Deapartment of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University
Alternatives to Animal Testing and Experimentation 15 (suppl) 224-224, 2010.
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M-3 Establishment of the method for quantitative prediction of detoxification ability and drug interaction in human liver by using human tissue sample and gene expression systems 〜Utilization of human tissue as alternative experimental systems to animal experiments〜
Kazuya Maeda, Naoki Kotani, Kenta Yoshida, Yuichi Sugiyama
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 15 (suppl) 225-225, 2010.
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CC-1 Experiments using water fleas
Sawako Yasuda
Yasu Municipal Yasu Elementary School
Alternatives to Animal Testing and Experimentation 15 (suppl) 226-226, 2010.
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CC-2 Proposals regarding experiments on leptin in frogs
Yuya Nakamoto, Takahiro Yamashita, Hiroto Kamosaki
Hiroshima Prefectural Hiroshima Kokutaiji High School
Alternatives to Animal Testing and Experimentation 15 (suppl) 227-227, 2010.
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CC-3 Application of snails' various sensor functions to medical care
Masaya Ohtsu
Toin Gakuen High School
Alternatives to Animal Testing and Experimentation 15 (suppl) 228-228, 2010.
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PS The use of human materials and information is indispensable in biomedical research: in the era of alternatives of animal experiments
Tohru Masui
Department of Disease Bioresources Research, National Institute of Biomedical Innovation
Alternatives to Animal Testing and Experimentation 15 (suppl) 229-229, 2010.
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P-1 Accuracy of LLNA: BrdU-ELISA to detect skin sensitization potential of chemicals
Hideki Miyaura1, Masafumi Horiuchi1, Naoaki Yakata1, Masahiro Takeyoshi1, Naomi Kawazu2, Masanori Taruki2
1Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, 2Hita Laboratory, Chemicals Evaluation and Research Institute
Alternatives to Animal Testing and Experimentation 15 (suppl) 230-230, 2010.
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P-2 Respiratory sensitization study by quantitative structure-activity relationships (QSAR)
Kazuhiro Sato1, Kohtaro Yuta2, Yukinori Kusaka1
1Department of Environmental Health, School of Medicine, University of Fukui, 2In Silico Data Co Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 231-231, 2010.
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P-3 Permeability prediction of phthalic esters for cultured human alveolar epithelial A549 cells
Genya Tanaka1, Kikuo Komori1, Takao Fujii1, Hideto Jinno2, Yasuyuki Sakai1
1Institute of Industrial Science, University of Tokyo, 2National institute of Health Sciences
Alternatives to Animal Testing and Experimentation 15 (suppl) 232-232, 2010.
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P-4 The development of an in vitro assay (ROS assay) to predict skin sensitization based on ROS production
Saito, Kazutoshi Saito, Masaaki Miyazawa, Yuko Nukada, Hiroki Sano, Hitoshi Sakaguchi, Naohiro Nishiyama
Kao Corporation
Alternatives to Animal Testing and Experimentation 15 (suppl) 233-233, 2010.
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P-5 Inter-laboratory validation study of in vitro eye irritation test; Short Time Exposure (STE) test (Part 3).
Kojima H.1, Kuwahara H.2, Hayashi T.2, Sakaguchi M.3, Toyoda A.3, Goto H.3, Nakamura T.4, Watanabe S.4, Ahiko K.4, Omori T.5, Otoizumi T.5, Sozu T.6, Morimoto T.7, Hayashi K.8, Sakaguchi H.8
1National Institute of health Sciences, 2Kanebo cosmetics Inc, 3POLA Chemical Industries, INC, 4LION Corporation, 5Doshisha University, 6Kyoto University, 7Sumitomo Chemical Co., Ltd, 8Kao Corporation
Alternatives to Animal Testing and Experimentation 15 (suppl) 234-234, 2010.
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P-6 Validation of a skin irritation study using a Japanese model; LabCyte EPI-MODEL24, Additional study
Kojima, H.1, Nakamura, M.2, Yamaguchi, Y.2, Izumi, R.3, Suzuki, T.3, Hagiwara, S.4, Shinoda, S.4, Kato, M.5
1NIHS, 2KOBAYASHI Pharmaceutical Co., Ltd, 3Fancl Corporation, 4Drug Safety Testing Center Co., Ltd, 5J-TEC
Alternatives to Animal Testing and Experimentation 15 (suppl) 235-235, 2010.
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P-7 Optimal conditions for performance of the comet assay using a three-dimensional human epidermal model
Hajime Kojima, Maki Hojyo
National Institute of Health Sciences (NIHS)
Alternatives to Animal Testing and Experimentation 15 (suppl) 236-236, 2010.
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P-8 The animal experiment substitute teaching materials in the high school science education
Hisashi Iwata
Iwami High School tottori prefectural
Alternatives to Animal Testing and Experimentation 15 (suppl) 237-237, 2010.
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P-9 Student practice incorporating alternative animal experiments in the faculty of pharmaceutical sciences
Tetsuya Hasegawa, Hiroshi Kawai, Kaori Matsumoto, Takuya Ishibashi, Kenjiro Matsumoto, Kimihito Tashima, Atsushi Mitsumoto, Yasuo Kodama, Syunji Horie, Masayuki Akimoto
Faculty of Pharmaceutical Science, Josai International University
Alternatives to Animal Testing and Experimentation 15 (suppl) 238-238, 2010.
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P-10 Involvement of acetylcholine and response to reduction in phosphorylated connexin43 in drug development research for ischemic heart disease
Hideto Ariumi, Ikuya Imai, Tomoko Miyazaki, Miyoshi Kawakami, Yuji Yoshiyama
Division of Community Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmacy, Kitasato University
Alternatives to Animal Testing and Experimentation 15 (suppl) 239-239, 2010.
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P-11 Establishment of in vitro test method for peel adhesion of adhesive tapes
Maki Shibuya1, Masako Yabe1, 2, Masaki Uchida1, Hideshi Natsume1, 3, Yasunori Morimoto1, 3
1Faculty of Pharmaceutical Sciences, Josai University, 2Department of Pharmacy Services, Ashikaga Red Cross Hospital, 3Research Institute of TTS Technology
Alternatives to Animal Testing and Experimentation 15 (suppl) 240-240, 2010.
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P-12 Evaluation of the Palatability by a Taste Sensor
Toshimi Iizuka, Hiroyuki Miyazaki, Hideto Ariumi, Yuji Yoshiyama
Division of Community Pharmacy Center for Clinical Pharmacy and Clinical Sciences, Kitasato University School of Pharmacy
Alternatives to Animal Testing and Experimentation 15 (suppl) 241-241, 2010.
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P-13 Statistical support models for validation studies
Taku Otoizumi, Takashi Omori
Doshisha University Faculty of Culture and Information Science
Alternatives to Animal Testing and Experimentation 15 (suppl) 242-242, 2010.
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P-14 Model-based approach to sensitivity, specificity, and accuracy in an interlaboratory validation study
Takashi Omori
Doshisya University Faculty of Culture and Information Science
Alternatives to Animal Testing and Experimentation 15 (suppl) 243-243, 2010.
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P-15 A molecular clock mechanism of cytochrome P450 (CYP) genes expression in serum-shocked HepG2 cells
Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University
Alternatives to Animal Testing and Experimentation 15 (suppl) 244-244, 2010.
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P-16 A highly sensitive cell-based screening method for CYP2C9-mediated metabolic activation with an adenovirus expression system
Atsushi Iwamura, Tatsuki Fukami, Hiroko Hosomi, Miki Nakajima, Tsuyoshi Yokoi
Faculty of Pharmaceutical Sciences, Kanazawa University
Alternatives to Animal Testing and Experimentation 15 (suppl) 245-245, 2010.
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P-17 Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation
Hiroko Hosomi, Tatsuki Fukami, Atsushi Iwamura, Miki Nakajima, Tsuyoshi Yokoi
Faculty of Pharmaceutical Sciences, Kanazawa University
Alternatives to Animal Testing and Experimentation 15 (suppl) 246-246, 2010.
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P-18 A basic study on migration to tissue of site probe drugs by using a cell membrane plate
Jin Tokunaga1, Norito Takamura1, Kenji Ogata1, Nao Setoguchi1, Nobunao Ikewaki1, Toyotaka Nishio2, Keiichi Kawai2
1School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 2School of Health Sciences, Kanazawa University
Alternatives to Animal Testing and Experimentation 15 (suppl) 247-247, 2010.
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P-19 Characterization of Light emitting-Bhas 42 Cells Using for Short Term Screening of Carcinogens
Shin Asada1, Kiyoshi Sasaki1, Ayako Sakai1, Yoshihiro Nakajima2, Yosihiro Ohmiya2, Noriho Tanaka1
1Hatano Research Institute, Food and Drug Safety Center, 2National Institute of Advanced Industrial Science and Technology
Alternatives to Animal Testing and Experimentation 15 (suppl) 248-248, 2010.
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P-20 An international validation study on a Bhas 42 cell transformation assay using 6-well plates for the prediction of chemical carcinogenicity
Ayako Sakai1, Kiyoshi Sasaki1, Kumiko Hayashi1, Dai Muramatsu1, Shoko Arai1, Nobuko Endou1, Sachiko Kuroda1, Fukutaro Mizuhashi2, Sawako Kasamoto2, Miho Nagai2, Masumi Asakura3, Hideki Hirose4, Nana Ishii4, Kamala Pant5, Shannon W.Bruce5, Jamie E.Sly5, Albrecht Poth6, Susanne Bohnenberger6, Thorsten Kunkelmann6, Shojiro Yamazaki1, Makoto Umeda1, Noriho Tanaka1
1Food and Drug Safety Center, 2Biosafety Research Center, Foods, Drugs and Pesticides, 3Japan Bioassay Research Center, 4Mitsubishi Chemical Medience Corporation, 5BioReliance Corporation, 6Harlan Cytotest Cell Research GmbH
Alternatives to Animal Testing and Experimentation 15 (suppl) 249-249, 2010.
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P-21 Screening of newly identified anti-cancer compounds using a human MDA-MB-231 cell line and analysis of their anti-neoplastic mechanism
Shuso Takeda1, Kazumasa Matsuo2, Yoshiko Okamoto1, Mitsuru Shindo2, Curtis J Omiecinski3, Hironori Aramaki1
1Department of Molecular Biology, Daiichi University of Pharmacy, 2Interdisciplinary Graduate School of Engineering Sciences and Institute for Materials Chemistry and Engineering, Kyushu University, 3Center for Molecular Toxicology and Carcinogenesis, 306D Life Sciences Building, Pennsylvania State University, University Park
Alternatives to Animal Testing and Experimentation 15 (suppl) 250-250, 2010.
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P-22 Development of high-performed prediction system for chemical toxicity in the cell using a human artificial chromosome (HAC) vector
Shigeyuki Yamaguchi1, Tetsuya Ohbayashi2, Yoshihiro Ohmiya3, Shigeaki Nishii4, Hideto Hoshino3, Tomomi Asai4, Yasuhiro Kazuki1, Mitsuo Oshimura1, 2
1Grad.Sch.Med., Inst.Regenerative Med.Biofunction., Tottori Univ, 2Res.Center.Biosci.Tech., Tottori Univ, 3Res.Inst.Cell Engineering., AIST, 4Tsuruga.Bio.Lab., Toyobo
Alternatives to Animal Testing and Experimentation 15 (suppl) 251-251, 2010.
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P-23 Generation of ES cells which monitor the cardiac muscle differentiation using a human artificial chromosome (HAC)
Yuki Yoshimura1, Shigeyuki Yamaguchi1, 2, Shiho Endo2, Yoshihiro Nakajima3, Yasuhiro Kazuki4, Yoshihiro Ohmiya5, Mitsuo Oshimura1, 4, Tetsuya Ohbayashi2
1Dept.of Biomed.Sci., Inst.of Regenerative Med., Tottori Univ, 2Div.of Laboratory Animal Sci., Res.Ctr.for Biosci.and Technology, Tottori Univ, 3Health Research Institute., Advanced Industrial Science And technology, 4Chromo.Eng.Res.Ctr., Tottori Univ, 5Bioproduction Research Institute., Advanced Industrial Science And Technology
Alternatives to Animal Testing and Experimentation 15 (suppl) 252-252, 2010.
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P-24 Establishment and characterization of engineered lymphatic endothelial cells with longer lifespan
Sugano M, Nakamura R, Kiyono M, Sone Y, Inoue K
Department of Public Health, School of Pharmacy, Kitasato University
Alternatives to Animal Testing and Experimentation 15 (suppl) 253-253, 2010.
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P-25 Investigation of the 3D cell culture system using a shape controlled Titanium coil
Takaki Shima, Kazutaka Yoshino, Akihiro Ametani, Yasuo Seki
HI-LEX Corporation Medical Device Department
Alternatives to Animal Testing and Experimentation 15 (suppl) 254-254, 2010.
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P-26 Rapid and spatially controlled formation of bile canaliculi in polarized hepatocyte in micropatterned collagen on oxygen-permeable membrane
Hitoshi Matsui1, 3, Hiroshi Kimura2, Tomoharu Osada3, Masaru Sekijima3, Teruo Fujii2, Shoji Takeuchi2, Yasuyuki Sakai2
1BEANS Laboratory, 2Institute of Industrial Science, The University of Tokyo, 3Mitsubishi Chemical Medience Co. Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 255-255, 2010.
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P-27 Efficient Reconstruction and Evaluation of a Pseudo-Islet Like Aggregate from an Oxygen Permeable Microwell Sheet
Marie Shinohara, Kikuo Komori, Teruo Fujii, Yasuyuki Sakai
Institution of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 15 (suppl) 256-256, 2010.
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P-28 Minimization of a Three-dimensional Liver Tissue for an In Vitro Toxicity Test
Kikuo Komori, Hiroaki Suzuki, Teruo Fujii, Yasuyuki Sakai
Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 15 (suppl) 257-257, 2010.
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P-29 Hydrogel electrode for effective electrical stimulation of cells
Y.Ido1, S.Sekine1, D.Takahashi1, K.Nagamine1, 2, T.Miyake1, 2, M.Nishizawa1, 2
1Tohoku University, 2JST-CREST
Alternatives to Animal Testing and Experimentation 15 (suppl) 258-258, 2010.
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P-30 A basic study of estimation of O2 and CO2 transfer in an oxygenator with a numerical analysis for minimization of the blood experiment
Katagiri N.1, Funakubo A.2, Tsukiya T.1, Tatsumi E.1, Mizuno T.1, Takewa Y.1, Shioya K.1, Taenaka Y.1, Fukui Y.2
1National Cerebral and Cardiovascular Center Research Institute, 2 Division of Electrical and Mechanical Engineering, Tokyo Denki University
Alternatives to Animal Testing and Experimentation 15 (suppl) 259-259, 2010.
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P-31 Evaluation of PDMS/PEG Copolymer Impregnated Membranes as a Human Skin Alternative for In Vitro Skin Permeation Testing
Ryotaro Miki1, Soichiro Kimura1, Toshinobu Seki1, Kazuhiko Juni1, Hideo Ueda1, Yasunori Morimoto1, 2
1Faculty of Pharmaceutical Sciences, Josai University, 2Research Institute of TTS Technology
Alternatives to Animal Testing and Experimentation 15 (suppl) 260-260, 2010.
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P-32 Evaluation of skin permeability of volatile substances: establishment of evaluation method using alternative membrane for animal skin
Takeshi Sugama, Takeshi Oshizaka, Hiroaki Todo, Kenji Sugibayashi
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 15 (suppl) 261-261, 2010.
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P-33 Effect of skin barrier function and metabolic ability on the in vitro skin irritation using cultured human skin models
Katsunori Furui, Hiroaki Todo, Kenji Sugibayashi
Josai university faculty of pharmaceutical sciences
Alternatives to Animal Testing and Experimentation 15 (suppl) 262-262, 2010.
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P-34 Alternative animal testing of skin sensitization test using three-dimensional human skin model involving dendritic cells
Tadashi Uchino1, Toshiaki Takazawa2, Yoshiaki Ikarashi1, Tetsuji Nishimura1
1National Institute of Health Sciences, 2National Institute of Agrobiological Sciences
Alternatives to Animal Testing and Experimentation 15 (suppl) 263-263, 2010.
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P-35 Investigation of an Eye Irritation Test Using a Human 3D Corneal Model (2nd Report)
Satoshi Nakahara
Central Research Laboratories, Mandom Corporation
Alternatives to Animal Testing and Experimentation 15 (suppl) 264-264, 2010.
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P-36 Evaluation of acute toxicity using Caenorhaboditis elegans
Maki Nakamura, Yoshihiro Yamaguchi, Hironori Tomi
KOBAYASHI Pharmaceutical Co., Ltd.Central R&D Laboratory
Alternatives to Animal Testing and Experimentation 15 (suppl) 265-265, 2010.
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P-37 Toxic interactions of clomipramine in chick embryos
Hiroyuki Miyazaki, Toshimi Iizuka, Motohiro Okayasu, Toshio Kouzuki, Takeshi Homma, Takashi Ogura, Yohhei Inada, Takenori Tamaki, Hideto Ariumi, Tomoko Miyazaki, Miyoshi Kido, Yuji Yoshiyama
Center for Clinical Pharmacy and Clinical Sciences, Kitasato University School of Pharmacy
Alternatives to Animal Testing and Experimentation 15 (suppl) 266-266, 2010.
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P-38 The effect of a biotin deficiency on cultured rat embryos
Noriko Ishizuka1, Masaharu Akita2, Sayaka Yanagida2, Atushi Yokoyama3, Naomi Kashiwazaki4, Junya Ito4, Masaru Maebashi5, Tomo Inomata4
1Kiryu University, 2Kamakura Women's University, 3Kanagawa Life Science Research Laboratory, 4Azabu University, 5Honjo 1st Hospital
Alternatives to Animal Testing and Experimentation 15 (suppl) 267-267, 2010.
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P-39 The Effect of chemical compound on Cultured Rat Embryos in S-9mix : Sodium Valproate
Masaharu Akita1, Noriko Ishizuka2, Atushi Yokoyama3
1Department of Nutrition and Dietetics, Kamakura Women's University, 2Department of Nutrition, Kiryu University, 3Life Science Laboratory of Kanagawa
Alternatives to Animal Testing and Experimentation 15 (suppl) 268-268, 2010.
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P-40 Development of in vitro alternative method for developmental toxicity in using differentiation of embryonic stem cells into neural cell
Noriyuki Suzuki, Satoshi Ando, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 269-269, 2010.
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P-41 Development of in vitro cardiotoxicity assays using human iPS cells (Investigation of assay conditions with doxorubicin)
Tomoaki Inoue, Jumpei Kiyokawa, Masaki Honda, Akifumi Shioda, Mitsuyasu Tabo, Masayuki Mishima, Shuichi Chiba
Safety Assessment Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 270-270, 2010.
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P-42 Characterization of human iPS-derived cardiomyocytes using gene expression analysis of cardiac markers
Jumpei Kiyokawa, Masaki Honda, Akifumi Shioda, Mitsuyasu Tabo, Masayuki Mishima, Shuichi Chiba, Tomoaki Inoue
Safety Assessment Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 271-271, 2010.
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P-44 Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system
Kazuaki Nakamura1, Yoko Ejiri2, Akito Tanoue1
1Department of Pharmacology, National Research Institute for Child Health and Development, 2Tsukuba Research Center, Kuraray Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 272-272, 2010.
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P-45 A genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells
Taisei Mizota, Katsutoshi Ohno, Toshihiro Yamada
The Food Safety Research Institute, Nissin Foods Holdings Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 273-273, 2010.
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P-46 Evaluation of in vitro micronucleus assay using three-dimensional reconstructed human skin model
Toshio Kasamatsu, Katsuyuki Yuki, Hideaki Nakagiri, Shoji Matsumura, Naohiro Ikeda, Naohiro Nishiyama
Global R&D-Safety Science, Kao Corporation
Alternatives to Animal Testing and Experimentation 15 (suppl) 274-274, 2010.
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P-47 In vitro evaluation system to predict phototoxic potential of water-insoluble chemicals using three-dimensional dermal skin model
Maki Kaneko, Masato Kitagaki, Hirokazu Kouzuki
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 15 (suppl) 275-275, 2010.
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P-48 Comparative Studies on the Draize Rabbit Eye Test and HET-CAM Test of Eye Irritation Test
So-Young Yang2, Nam-Jin Lee2, Eun Young Jeon2, Mi Sook Jung2, Heung-Mo Bae2, Jae-Myun Ryu2, Seong-Jin Baek2, Jong-Koo Kang1
1Department of Veterinary Medicine, Chungbuk National University, 2Biotoxtech Co.Ltd, 2Ochang Scientific Industrial complex
Alternatives to Animal Testing and Experimentation 15 (suppl) 276-276, 2010.
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P-49 Advantages of the human corneal epithelium model reconstructed in a collagen vitrigel chamber and its application to eye irritation test.
Hiroyuki Yamaguchi1, 2, Toshiaki Takezawa1
1National Institute of Agrobiological Sciences, 2Kanto Chemical Co.Inc
Alternatives to Animal Testing and Experimentation 15 (suppl) 277-277, 2010.
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P-50 Assessment of eye irritation potencial using the reconstructed human corneal tissue, LabCyte CORNEA-MODEL
Masakazu Katoh, Noriyuki Uemura, Akemi Usui, Fumiyasu Hamajima, Takahiro Ogasawara, Ken-ichiro Hata
Japan Tissue Engineering Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 278-278, 2010.
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P-51 Assessment of novel eye irritation test using the reconstructed human corneal tissue LabCyte CORNEA-MODEL
Noriyuki Uemura, Masakazu Katoh, Akemi Usui, Ken-ichiro Hata
Japan Tissue Engineering Co., Ltd
Alternatives to Animal Testing and Experimentation 15 (suppl) 279-279, 2010.
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P-52 Risk assessment for eye irritation using cytotoxicity tests
Shigenobu Hagino, Yuuko Matsumoto, Kitagaki Masato, Tsuyoshi Yoshida, Hiroshi Itagaki
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 15 (suppl) 280-280, 2010.
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P-53 Discrimination of GHS classification 2A or 2B in modified STE test by neutral red(NR) up-take
Yuichiro Goto, Miki Nakanishi, Miho Sakurai, Satoko Kuriwada, Noriyasu Imai, Yuko Okamoto
KOSE Corporation Fundamental Research Laboratories
Alternatives to Animal Testing and Experimentation 15 (suppl) 281-281, 2010.
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P-54 Assessment approach (NI/I) combining in vitro eye irritation tests
Kenichi Ooshima1, Takayuki Abo2, Takumi Hayashi1, Tomoko Komano1, Kazuhiko Hayashi2, Hitoshi Sakaguchi2, Naohiro Nishiyama2, Hirofumi Kuwahara1
1Kanebo cosmetics INC, 2Kao Corporation
Alternatives to Animal Testing and Experimentation 15 (suppl) 282-282, 2010.
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P-55 A tiered approach combining the STE test, EpiOcular(TM) assay, BCOP assay for predicting eye irritation potential of chemicals
Takayuki Abo1, Kenichi Ooshima2, Kazuhiko Hayashi1, Takumi Hayashi2, Tomoko Komano2, Hitoshi Sakaguchi1, Hirofumi Kuwahara2, Naohiro Nishiyama1
1Kao Corporation, 2Kanebo cosmetics INC
Alternatives to Animal Testing and Experimentation 15 (suppl) 283-283, 2010.
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