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Alternatives to Animal Testing and Experimentation 17巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN（オンライン）
2185-4726
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開始頁
Importance of modeling and simulation in “Alternative to Animal Experiments Research”
YUICHI SUGIYAMA
Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Alternatives to Animal Testing and Experimentation 17 (suppl) 102-102, 2012.
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1 Direct reprogramming of stem cells into functional hepatocytes by micromanager
TAKAHIRO OCHIYA
National Cancer Center Research Institute
Alternatives to Animal Testing and Experimentation 17 (suppl) 103-103, 2012.
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2 Skin sensitization study by a new qualitative structure-toxicity relationships(QSTR)approach：K-step Yard sampling(KY)methods
KAZUHIRO SATO
Faculty of Medicine, University of Fukui
Alternatives to Animal Testing and Experimentation 17 (suppl) 104-104, 2012.
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The proposal to the verification system for the laboratory animal use in Universities -from the standpoint of the institution received the verification-
TAKASHI AGUI
Laboratory of Laboratory Animal Science and Medicine, Graduate School of Veterinary Medicine, Hokkaido University
Alternatives to Animal Testing and Experimentation 17 (suppl) 105-105, 2012.
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Functional Human Liver Tissue From An Induced Pluripotent Stem Cell-Derived Organ Bud Transplant
Hideki TANIGUCHI
Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University
Alternatives to Animal Testing and Experimentation 17 (suppl) 106-106, 2012.
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S1-1 Current Safety Evaluation Methods for Cosmetic Ingredients -Comprehensive Summary-
Shigenobu Hagino1, Yuko Okamoto2
1Shiseido Research Center, 2KOSE Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 107-107, 2012.
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S1-2 Trends in alternative primary skin irritation test for the evaluation of cosmetic ingredients
Hidenobu Okumura
Special committee on alternative primary skin irritation test, Japan Society of Alternatives to Animal Experiments
Alternatives to Animal Testing and Experimentation 17 (suppl) 108-108, 2012.
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S1-3 Trend of Alternative Methods to Eye Irritation Test for Evaluating Cosmetic Ingredients
Momoko Sunouchi
National Institute of Health Sciences, Japanese Center for the Validation of Alternative methods
Alternatives to Animal Testing and Experimentation 17 (suppl) 109-109, 2012.
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S1-4 Trend of alternative methods of phototoxicity test for evaluating cosmetic ingredients
Noriyasu IMAI
Fundamental Research Laboratories, KOSE Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 110-110, 2012.
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S1-5 Trend of Alternative Methods to Single Dose Toxicity Test for Evaluating Cosmetic Ingredients
Tomomi Atobe
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 17 (suppl) 111-111, 2012.
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S1-6 Collaborative project in JCIA for evaluation of skin sensitization using non-animal tests
Masaaki Miyazawa
Working group for in vitro skin sensitization in Japan Cosmetic Industry Association (JCIA)
Alternatives to Animal Testing and Experimentation 17 (suppl) 112-112, 2012.
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S1-7 Approach of JCIA for safety assessment of cosmetic ingredients in silico
Amane Inoue
In silico working group, Japan Cosmetic Industry Association (JCIA)
Alternatives to Animal Testing and Experimentation 17 (suppl) 113-113, 2012.
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S2-1 Quantitative Prediction of Human Pharmacokinetics with Human-derived Tissue Samples and Gene Expression Systems 〜 Overview〜
Kazuya Maeda
Dept. of Molecular Pharmacokinetics, Graduate School of Pharm. Sci., The Univ. of Tokyo
Alternatives to Animal Testing and Experimentation 17 (suppl) 114-114, 2012.
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S2-2 In vitro evaluation of transplacental drug transport mechanisms
Masatoshi Tomi, Tomohiro Nishimura, Emi Nakashima
Faculty of Pharmacy, Keio University
Alternatives to Animal Testing and Experimentation 17 (suppl) 115-115, 2012.
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S2-3 Establishment of in vitro P-glycoprotein inhibition assay and its application
Hiroshi Sugimoto1, Shin-ichi Matsumoto2, Shin-ichi Niwa2, Hideki Hirabayashi1, Nobuyuki Amano1, Toshiya Moriwaki1
1Drug Metabolism and Pharmacokinetics Research Laboratories, 2Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 116-116, 2012.
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S2-4 Establishment of an immortalized cell-based in vitro human blood-brain barrier model： Current status and future perspectives
Tomomi Furihata, Atsuko Kamiichi, Satoshi Kishida, Shinya Kawamatsu, Yuki Ohta, Kosuke Saito, Kan Chiba
Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 17 (suppl) 117-117, 2012.
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S2-5 Model analysis on PK/PD relationship of antibiotics： Theoretical exploration for the most predictive index of pharmacological action
Yoshiaki Kitamura1, Kenta Yoshida2, Makiko Kusama2, Yuichi Sugiyama3
1Discovery Research Laboratories, Kyorin Pharmaceutical Co.,Ltd., 2Graduate school of Pharmaceutical Sciences, The University of Tokyo, 3Sugiyama Laboratory, RIKEN (The Institute of Physical and Chemical Research)
Alternatives to Animal Testing and Experimentation 17 (suppl) 118-118, 2012.
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S3-1 General purpose of the symposium and related considerations from engineering point of view：microfluidics, micropatterning, 3D cellular organization and mass transfer
Yasuyuki SAKAI
Organs and Biosystems Engineering Lab., Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 17 (suppl) 119-119, 2012.
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S3-2 The Current status and Issues of Cell-based Assay in Drug Development and Safety 〜Expectation for next cell-based assay technology〜
Motoharu Kakiki
Tsukuba Research Laboratory, Eisai. Co.Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 120-120, 2012.
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S3-3 Spheroid array and cell-based assay
Kohji NAKAZAWA
Department of Life and Environment Engineering, The University of Kitakyushu
Alternatives to Animal Testing and Experimentation 17 (suppl) 121-121, 2012.
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S3-4 Microfluidic Device for Cell-Based Assay
Shinji Sugiura, Yusuke Sakai2, Koji Hattori1, Kohji Nakazawa2, Toshiyuki Kanamori1
1National Institute of Advanced Industrial Science and Technology (AIST), 2The University of Kitakyushu
Alternatives to Animal Testing and Experimentation 17 (suppl) 122-122, 2012.
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S3-5 Body on a Chip： Improving In Vitro Predictions of Human Response to Drugs
Michael L.Shuler
Department of Biomedical Engineering, Cornell University
Alternatives to Animal Testing and Experimentation 17 (suppl) 123-124, 2012.
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S4-1 Recent trends and possibility on the in silico prediction
Hiroaki Todo
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 17 (suppl) 125-125, 2012.
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S4-2 Safety assessment of cosmetic ingredients using the predictive percutaneous absorption in silico
Hirokazu Kouzuki
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 17 (suppl) 126-126, 2012.
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S4-3 In Silico Prediction of Percutaneous Penetration
K.Tojo1, Hikima T.1, Mori D.2
1Kyushu Institute of Technology, 2Biocom Systems Co Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 127-127, 2012.
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S5-1 Current situation and future prospects of exploratory IND studies in Japan
Shinji Yamashita1
Faculty of Pharmaceutical Sciences, Setsunan University
Alternatives to Animal Testing and Experimentation 17 (suppl) 128-128, 2012.
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S5-2 Prediction of pharmacokinetic properties and respose of drugs based on microdose study
Hiroyuki Kusuhara
Graduate School of Pharmaceutical Sciences, the University of Tokyo
Alternatives to Animal Testing and Experimentation 17 (suppl) 129-129, 2012.
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S5-3 Nonclinical development for first-in human studies under the current regulatory requirements
Eiichi FUSE
Clinical Science Department, Development Division, Kyowa Hakko Kirin Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 130-130, 2012.
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S5-4 Use of PKPD modeling in optimizing exploratory clinical studies
Ryosei Leo Kawai
Daiichi Sankyo Co.Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 131-131, 2012.
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S6-1 Outline of symposium： Advantages of collagen vitrigel and its leading-edge studies
Toshiaki Takezawa1, Seiichi Ishida2
1National Institute of Agrobiological Sciences, 2National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 17 (suppl) 132-132, 2012.
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S6-2 Development of a new eye irritation test method utilizing a collagen vitrigel membrane chamber.
Hiroyuki Yamaguchi1,3, Hajime Kojima2, Toshiaki Takezawa1
1National Institute of Agrobiological Sciences, 2National Institute of Health Sciences, 3Kanto Chemical Co.,Inc.
Alternatives to Animal Testing and Experimentation 17 (suppl) 133-133, 2012.
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S6-3 Development of a new skin sensitization test method utilizing a collagen vitrigel membrane chamber
Uchino T.1, Shimizu K.1, Takezawa T.2, Yamashita K.3, Kojima H.1, Ikarashi Y.1, Akiyama T.1
1National Institute of Health Sciences, 2National Institute of Agrobiological Sciences, 3Daicel Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 134-134, 2012.
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S6-4 Development of a new hepatic metabolism model utilizing a collagen vitrigel membrane chamber
Ayumi Oshikata1, Seiichi Ishida2, Toshiaki Takezawa1
1National Institute of Agrobiological Sciences, 2National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 17 (suppl) 135-135, 2012.
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IS-1 Transcriptional profiling studies of cosmetic ingredients in human keratinocytes to discover novel biomarkers for skin irritation tests
Minsoo Noh1, Ai-Young Lee2
1Department of Pharmacy, Ajou University, Suwon, 2Department of Dermatology, Dongguk University School of Medicine
Alternatives to Animal Testing and Experimentation 17 (suppl) 137-137, 2012.
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IS-2 Level of interleukin-6 and interleukin-18 production from keratinocyte cell line could be a potential candidate for screening skin sensitizing chemicals
So Nam Kim1, Kyeong Uk Yeo1, Hyoung Ah Kim2, Yong Heo1
1Catholic University of Daegu, College of Natural Sciences, Dept. Occupational Health, 2The Catholic University of Korea, School of Medicine, Dept. Preventive Medicine
Alternatives to Animal Testing and Experimentation 17 (suppl) 138-138, 2012.
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IS-3 Alternative methods in the strategy of local toxicity assessment of chemicals and consumer products
Jirova D1, Liebsch M2, Kejlova K1, Kandarova H3, Bendova H1, Basketter D4
1National Institute of Public Health, Prague, 2ZEBET, Federal Institute for Risk Assessment, 3MatTek In Vitro Life Science Laboratories, 4DABMEB Consultancy Ltd
Alternatives to Animal Testing and Experimentation 17 (suppl) 139-139, 2012.
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M-1 Search for new candidate drugs for Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2)
Hisamitsu Hayashi
Graduate School of Pharmaceutical Sciences, Univ. of Tokyo
Alternatives to Animal Testing and Experimentation 17 (suppl) 140-140, 2012.
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M-2 Development of a cell-based model of the retina within a microfluidic device
Hirokazu Kaji1, Syuntaro Ito1, Nobuhiro Nagai2, Kuniaki Nagamine1, Matsuhiko Nishizawa1, Toshiaki Abe2
1Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 2United Center for Advanced Research and Translational Medicine, Tohoku University Graduate of Medicine
Alternatives to Animal Testing and Experimentation 17 (suppl) 141-141, 2012.
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M-3 Development of biomimetic tissues from commercial cell lines： The promising alternative tools for laboratory animals
Jeong Ik Lee
Regenerative Medicine Laboratory, Stem Cell Research Center, Department of Biomedical Science and Technology, SMART Institute of Advanced Biomedical Science, Konkuk University
Alternatives to Animal Testing and Experimentation 17 (suppl) 142-142, 2012.
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M-4 Acetylcholine inhibits the hypoxia and hydrogen peroxide -induced reduction of connexin43 protein in rat cardiomyocytes
Hideto Ariumi
Division of Community Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmacy, Kitasato University
Alternatives to Animal Testing and Experimentation 17 (suppl) 143-143, 2012.
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M-5 A study of the eye irritation test using new immortalized human corneal epithelium.
Naoki Yamamoto
Laboratory of molecular biology and histochemistry, Joint research laboratory, Fujita Health University
Alternatives to Animal Testing and Experimentation 17 (suppl) 144-144, 2012.
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O1-1 Novel 3D culture technology of neurologic cells with in situ observable device composed of ECM modelized material
Hideyuki Mizumachi, Hiroyuki Ijima
Kyushu University
Alternatives to Animal Testing and Experimentation 17 (suppl) 145-145, 2012.
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O1-2 Non-Adhesive Single Cell Culture for Primary Rat Hepatocytes
Hiroyuki Ijima, Jun-ichi Sakai
Kyushu University
Alternatives to Animal Testing and Experimentation 17 (suppl) 145-145, 2012.
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O1-3 Three Dimensional Cancer Tissue Cultured by RWV Bioreactor and the Effect of Anticancer Drug
Toshimasa Uemura
NRI (Nanosystem Research Institute), AIST (National Institute of Advanced Industrial Science and Technology)
Alternatives to Animal Testing and Experimentation 17 (suppl) 146-146, 2012.
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O1-4 Cytotoxicity assay of TiO2 particles using pulmonary epithelial cells
Kokoro Iwasawa1, Atsuhiro Tomita2, Takuya Aoyama1, Yasuyuki Sakai1
1Institute of Industrial Science, The University of Tokyo, 2College of Arts and Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 17 (suppl) 147-147, 2012.
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O1-5 Functions and gene expressions of rat hepatocytes under different cultures using oxygen-permeable membranes for drug screening
W.J Xiao1, M.Shinohara1, K.Komori1, M.Kodama2, Y.Sakai1
1Institute of Industrial Science (IIS), University of Tokyo, 2Vessel Co.,Ltd
Alternatives to Animal Testing and Experimentation 17 (suppl) 148-148, 2012.
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O1-6 Size-regulated aggregates formation in microwell with direct oxygenation -Pancreatic β-cell and hepatocyte reorganization into aggregates and their size-dependent function-
M.Shinohara1, T.Kido2, H.Kimura1, K.Komori1, T.Fujii1, A.Miyajima2, Y.Sakai1
1Institute of Industrial Science, The University of Tokyo, 2Institute of Molecular and Cellular Bioscience, The University of Tokyo
Alternatives to Animal Testing and Experimentation 17 (suppl) 148-148, 2012.
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O1-7 Development of three dimensional cell culture module with the hollow-fiber membrane -about cell growth of hepatocytes-
Nozomu Shibuya1, Takaaki Ishii2, Tatsunobu Fukushima1, Taku Matsushita2
1Yokohama Corporate Research Laboratories, Mitsubishi RAYON Co.,Ltd., 2Department of Applied Life Science, Sojo University
Alternatives to Animal Testing and Experimentation 17 (suppl) 149-149, 2012.
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O1-8 Development of three dimensional cell culture module with the hollow-fiber membrane -about cell function of hepatocytes-
Takaaki Ishii2, Nozomu Shibuya1, Tatsunobu Fukushima1, Taku Matsushita2
1Yokohama Corporate Research Laboratories, Mitsubishi RAYON Co.,Ltd., 2Department of Applied Life Science, Sojo University
Alternatives to Animal Testing and Experimentation 17 (suppl) 149-149, 2012.
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O1-9 The Dependence of Metabolic Functions on the Hepatocyte Spheroid Size Cocultured with Fibroblast
Saya Okimura1, Masako Nagamura1, Kouhei Sasaki1, Satoshi Suzuki2, Hidenori Otsuka1
1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 2Human & Animal Bridging Research Organization
Alternatives to Animal Testing and Experimentation 17 (suppl) 150-150, 2012.
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O1-10 Stabilization of hepatocyte spheroids by coculture method and their metabolic function
Masako Nagamura1, Saya Okimura1, Satoshi Suzuki2, Hidenori Otsuka1
1Tokyo Univ. of Science, 2Human and Animal Bridging (HAB) Research Organization
Alternatives to Animal Testing and Experimentation 17 (suppl) 150-150, 2012.
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O1-11 Application of the three dimensional spheroid culture systems for CYP induction assay with rat primary hepatocytes
Hirotoshi Okumura1, Motoki Ochi1, Satoshi Wakabayashi1, Jun-ichi Yamaguchi1
1Pharmacokinetics and Metabolism Laboratory, Taisho Pharmaceutical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 151-151, 2012.
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O2-1 Development of the in vitro photo-sensitization assay by detecting changes of oxidative stress
Hayato Nishida1, Shiho Oeda1, Kyoko Tsujita1, Tomomi Atobe1, Takao Ashikaga1, Morihiko Hirota1, Hirokazu Kouzuki1, Yoshiki Tokura2
1Shiseido Research Center, 2Department of Dermatology, Hamamatsu University School of Medicine
Alternatives to Animal Testing and Experimentation 17 (suppl) 151-151, 2012.
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O2-2 Impact of Exposure Profile on Toxic Response Using Hepatocytes (HepaRG) Co-cultured with Intestinal Cells (Caco-2)
Katsuyuki Yuki, Naohiro Ikeda, Toshio Kasamatsu, Naohiro Nishiyama
R&D-Safety Science Research, Kao Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 152-152, 2012.
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O2-3 Collaboration study on eye irritation alternative method with human corneal mode； LabCyte CORNEA-MODEL24
Hajime Kojima1, Nozomi Annaka2, Seiichirou Tsuchiya3, Yuichiro Yoshitake4, Rui Xu5, Masaru Suzuki6, Wataru Shimatani7, Akemi Kajita8, Maki Nakamura9, Mika Watanabe10, Madoka Nakajima11, Kouji Sakamoto12, Ryuji Takeda13, Masayoshi Hisama14, Hidefumi Ikeda15, Aimi Inagaki16, Yukimi Munechika17, Yutaka Yamamoto18, Toshihiko Kasahara19, Takayuki Fukuda20, Satoshi Nakahara21, Shinichi Watanabe22, Hayato Kurata23, Shinsuke Shinoda24, Masakazu Katoh25
1National Institute of Health Science, 2IVY COSMETICS CO.,LTD, 3ISHIHARA SANGYO KAISHA, LTD, 4OPPEN COSMETICS Co., 5Kao Corporation, 6Chemicals Evaluation and Research Institute, 7Safety Research Institute for Chemical Compounds Co.,Ltd., 8Kamakura Techno-Science, 9Kobayashi Pharmaceutical Co.,Ltd., 10Hatano Research Institute, Food and Drug Safety Center, 11BioSafety Research Center, 12Taisho Pharmaceutical Co.,Ltd., 13DRC CO.,LTD, 14TOYO BEAUTY CO.,LTD, 15Nihon Kolmar Co.,Ltd., 16Japan Food Research Laboratories, 17Nihon Nohyaku Co.,Ltd., 18NOEVIR Co.,Ltd., 19FUJIFILM Co., 20BOZO Research Center Inc., 21Mandom Corporation, 22LION CORPORATION, 23ROHTO Pharmaceutical Co.,Ltd., 24Drug Safety Testing Center Co.,Ltd, 25Japan Tissue Engineering Co.,Ltd
Alternatives to Animal Testing and Experimentation 17 (suppl) 153-153, 2012.
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O2-4 Interspecies differences in glibenclamide-induced bile acid dependent hepatotoxicity between rat and human sandwich cultured hepatocytes.
Takeshi Susukida, Shuichi Sekine, Eiichiro Ogimura, Toshiharu Horie
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 17 (suppl) 154-154, 2012.
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O2-5 3-D tumor model for in vitro evaluation of anticancer drugs using silicate electrospum nanofibers
Yamaguchi Y1, Deng D1, Masunaga S1, Watanabe R2, Kawabe M2, Yamaguchi S1, Hirano E1, Morinaga T1

Alternatives to Animal Testing and Experimentation 17 (suppl) 154-154, 2012.
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O2-6 Establishment of in vitro assay system to predict the unbound concentration in liver
Kazuaki Ikejiri1, Kazuya Maeda1, Hiroyuki Kusuhara1, Yuichi Sugiyama2
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, Research Cluster for Innovation
Alternatives to Animal Testing and Experimentation 17 (suppl) 155-155, 2012.
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O2-7 Physiologically-based pharmacokinetic (PBPK) modeling analyses of clinical drug-drug interactions (DDIs) using a new global parameter optimization method
Kenta Yoshida1,2, Kazuya Maeda1, Hiroyuki Kusuhara1, Akihiko Konagaya2, Yuichi Sugiyama3
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 3RIKEN Research Cluster for Innovation
Alternatives to Animal Testing and Experimentation 17 (suppl) 155-155, 2012.
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O3-1 Evaluation of nanotoxic effects on brain using in vitro models
Kouki Fujioka1, Sanshiro Hanada2, Yuriko Inoue3, Kouichi Shiraishi1, Fumihide Kanaya2, Yoshinobu Manome1
1The Jikei University School of Medicine, 2National Center for Global Health and Medicine, 3Toho University
Alternatives to Animal Testing and Experimentation 17 (suppl) 156-156, 2012.
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O3-2 Development of Novel Tissue Models Based on Hierarchical Cell Manipulation
Akihiro Nishiguchi, Michiya Matsusaki, Mitsuru Akashi
Department of Applied Chemistry, Graduate School of Engineering, Osaka University
Alternatives to Animal Testing and Experimentation 17 (suppl) 156-156, 2012.
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O3-3 Single adult kidney stem/progenitor cells reconstitute three-dimensional nephron structures in vitro
Shinji Kitamura, Hirofumi Makino
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Alternatives to Animal Testing and Experimentation 17 (suppl) 157-157, 2012.
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O3-4 An inter-laboratory validation study of IL-8 Luc assay -The results of Phase I and Phase IIa study and future prospects-
Yutaka Kimura1, Mika Watanabe2, Rumiko Saito2, Noriyuki Suzuki3, Tomoko Iwaki4, Ai Kaneko5, Megumi Takata5, Yumi Tanaka5, Aya Watanabe5, Kohji Yamakage2, Koichi Saito3, Yoshihiro Nakajima4, Yoshihiro Ohmiya6, Ayako Sakai2, Takashi Omori5, Shojiro Yamazaki2, Hajime Kojima7, Noriho Tanaka2, Setsuya Aiba1
1Department of Dermatology, Tohoku University Graduate School of Medicine, 2Hatano Research Institute, Food and Drug Safety Center, 3Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd., 4Health Research Institute, Advanced Industrial Science And technology, 5Doshisha University, 6Biomedical Research Institute, Advanced Industrial Science And technology, 7National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 17 (suppl) 157-157, 2012.
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O3-5 An embryonic stem cell test with the assay system for cell death and cell proliferation
Nakamura K1, Kato N1, Aizawa K1, Imai K2, Tanoue A1
1National Research Institute for Child Health and Development, 2Department of Biomaterials, Osaka Dental University
Alternatives to Animal Testing and Experimentation 17 (suppl) 158-158, 2012.
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O3-6 An in vitro embryotoxicity test with the hybrid culture of human hepatocytes and mouse ES cells
Imai K1, Takeda S1, Nakamura K2, Tanoue A2
1Department of Biomaterials, Osaka Dental University, 2Department of Pharmacology, National Research Institute for Child Health and Development
Alternatives to Animal Testing and Experimentation 17 (suppl) 159-159, 2012.
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P-1 Collaborative project in JCIA for evaluation of skin sensitization using non-animal tests (first report) -Testing strategy with h-CLAT, DPRA and DEREK-
Osamu Takenouchi1,11, Shiho Fukui2,11, Kenji Okamoto2,11, Noriyasu Imai3,11, Satoru Kurotani3,11, Miyuki Fujishiro4,11, Daiki Kyotani4,11, Yoshinao Kato5,11, Toshihiko Kasahara6,11, Masaharu Fujita6,11, Akemi Toyoda7,11, Daisuke Sekiya8,11, Shinichi Watanabe8,11, Hirokazu Seto9,11, Morihiko Hirota10,11, Takao Ashikaga10,11, Masaaki Miyazawa1,11
1Kao Corporation, 2Kanebo Cosmetics Inc., 3KOSE Corporation, 4COSMOS TECHNICAL CENTER CO.,LTD., 5NIPPON MENARD COSMETIC CO.,LTD., 6FUJIFILM Corporation, 7POLA CHEMICAL INDUSTRIES, INC., 8LION CORPORATION, 9P&G Japan K.K., 10SHISEIDO CO.,LTD., 11Working group for in vitro skin sensitization evaluation in Japan Cosmetic Industry Association
Alternatives to Animal Testing and Experimentation 17 (suppl) 160-160, 2012.
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P-2 Collaborative project in JCIA for evaluation of skin sensitization using non-animal tests (second report). -Development of evaluation system using artificial neural network analysis-
Morihiko Hirota1,11, Shiho Fukui2,11, Kenji Okamoto2,11, Satoru Kurotani3,11, Noriyasu Imai3,11, Miyuki Fujishiro4,11, Daiki Kyotani4,11, Yoshinao Kato5,11, Toshihiko Kasahara6,11, Masaharu Fujita6,11, Akemi Toyoda7,11, Daisuke Sekiya8,11, Shinichi Watanabe8,11, Hirokazu Seto9,11, Osamu Takenouchi10,11, Takao Ashikaga1,11, Masaaki Miyazawa1,11
1SHISEIDO CO.,LTD., 2Kanebo Cosmetics Inc., 3KOSE Corporation, 4COSMOS TECHNICAL CENTER CO.,LTD., 5NIPPON MENARD COSMETIC CO.,LTD., 6FUJIFILM Corporation, 7POLA CHEMICAL INDUSTRIES, INC., 8LION CORPORATION, 9P&G Japan K.K., 10Kao Corporation, 11Working group for in vitro skin sensitization evaluation in Japan Cosmetic Industry Association
Alternatives to Animal Testing and Experimentation 17 (suppl) 161-161, 2012.
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P-3 Collaborative project in JCIA for evaluation of skin sensitization using non-animal tests (third report) -Using logistic regression model-
Kenji Okamoto1,11, Shiho Fukui1,11, Satoru Kurotani2,11, Noriyasu Imai2,11, Miyuki Fujishiro3,11, Daiki Kyotani3,11, Yoshinao Kato4,11, Toshihiko Kasahara5,11, Masaharu Fujita5,11, Akemi Toyoda6,11, Daisuke Sekiya7,11, Shinichi Watanabe7,11, Hirokazu Seto8,11, Morihiko Hirota9,11, Osamu Takenouchi10,11, Takao Ashikaga9,11, Masaaki Miyazawa10,11
1Kanebo Cosmetics Inc., 2KOSE Corporation, 3COSMOS TECHNICAL CENTER CO.,LTD., 4NIPPON MENARD COSMETIC CO.,LTD., 5FUJIFILM Corporation, 6POLA CHEMICAL INDUSTRIES, INC., 7LION CORPORATION, 8P&G Japan K.K., 9SHISEIDO CO.,LTD., 10Kao Corporation, 11Working group for in vitro skin sensitization evaluation in Japan Cosmetic Industry Association
Alternatives to Animal Testing and Experimentation 17 (suppl) 162-162, 2012.
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P-4 Development of new LLNA：DA that incorporated the elicitation phase
Kunihiko Yamashita1, Kenji Idehara1, Shinsuke Shinoda2, Saori Hagiwara2
1Daicel Corporation, 2Drug Safety Testing Center Co.Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 162-162, 2012.
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P-5 Quantitative evaluation of murine local lymph node assays based on OECD TG429 using CBA/J or CBA/Ca mice and OECD TG442B using CBA/J mouse
Yosuke Maeda1, Haruka Hirosaki1, Naoaki Yakata1, Toshio Kobayashi2, Masanori Taruki3, Masahiro Takeyoshi1
1Chemicals Assessment and Research Center, Chemicals Evalution and Research Institute, 2Hita Laboratory, Chemicals Evalution and Research Institute, 3Kurume Laboratory, Chemicals Evalution and Research Institute
Alternatives to Animal Testing and Experimentation 17 (suppl) 163-163, 2012.
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P-6 Primary Skin Irritation Test of Textiles according to JIS L 1918 Using LabCyte EPI-Model
Mika Watanabe, Miwako Kobayashi, Mayu Ikezumi, Kohji Yamakage
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 17 (suppl) 164-164, 2012.
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P-7 Study of in vitro skin irritation test targeted for sensitive skin (Part 2)
Hidefumi Ikeda, Hideki Nishiura
R&D Basic Research Nihon Kolmer Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 164-164, 2012.
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P-8 Evaluation of skin irritation of oil-soluble materials using monolayer culture system
Shigeyuki Nomura, Yuichiro Goto, Koko Tanigawa, Noriyasu Imai, Takuji Masunaga
Fundamental Research Laboratories, KOSE Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 165-165, 2012.
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P-9 Prediction of skin sensitization potency of acrylates by structure-activity relationship analysis
Masaharu Fujita, Toshihiko Kasahara, Takanori Hioki
1Safety Evaluation Center, Environment & Quality Management Div., CSR Div., FUJIFILM Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 165-165, 2012.
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P-10 Testing strategy for skin sensitization by using in vitro test aiming at risk assessment for fragrance materials.
Hiroki Sano, Yuko Nukada, Hitoshi Sakaguchi, Naohiro Nishiyama
Kao Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 166-166, 2012.
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P-11 The inter-laboratory reproducibility of the STE test for assessing eye irritation of cosmetic products
T.Abo1, M.Watanabe2, A.Hilberer3, A.Heppenheimer4, K.Ooshima3, D.Cameron6, A.Kirst7, Y.Nukada1, H.Sakaguchi1, N.Nishiyama1
1Kao Corporation, 2Food and Drug Safety Center, 3Institute for In Vitro Science, 4Harlan Cytotest Cell Research, 5Kanebo Cosmetics, 6Kao USA, 7Kao Germany
Alternatives to Animal Testing and Experimentation 17 (suppl) 167-167, 2012.
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P-12 Definition of the Applicability Domain of in vitro eye irritation test “STE test” -Progress towards the peer-review-
Yuko Nukada, Takayuki Abo, Hitoshi Sakaguchi, Naohiro Nishiyama
Kao Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 168-168, 2012.
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P-13 The Bovine Corneal Opacity and Permeability (BCOP) test method for assessment of the ocular irritation
Takashi Sakakibara1, Masumi Rokukawa1, Kohta Itoh1, Kohtaro Kawamura1, Masatoshi Furukawa1, Shiro Fujihira1, Takeo Hiraga2, Hajime Kojima3, Masao Matsuura1
1Safety Research Institute for Chemical Compounds, Co.,Ltd, 2Department of Veterinary Medicine, Rakuno Gakuen University, 3National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 17 (suppl) 169-169, 2012.
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P-14 An international validation study：in vitro alternative method for eye irritation using SIRC-CVS cytotoxicity test
Momoko Sunouchi1, Takayuki Fukuda2, Hidefumi Ikeda3, Mi-Sook Jung4, Takashi Omori5, Yumi Tanaka5, Kohji Yamakage6, Shigenobu Hagino7, Hajime Kojima1
1JaCVAM, NIHS, 2BOZO Research Center Inc., Tokyo Laboratory, 3Nihon Kolmar Co.,Ltd., R&D, 4Biotoxtech Co.Ltd., 5Doshisha University, 6Hatano Research Institute, FDSC, 7Shiseido Research Center
Alternatives to Animal Testing and Experimentation 17 (suppl) 170-170, 2012.
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P-15 The application proposal of the in silico technology to determine critical endpoints based on result of several different experimental methods
Kohtaro Yuta
In silico data, Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 170-170, 2012.
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P-16 Strategic phototoxic risk assessment on phenothiazine derivatives
Masashi Kato1, Ryo Inoue1, Yoshiki Seto1, Satomi Onoue1, Shizuo Yamada1
1Department of pharmacokinetics and pharmacodynamics, Graduate School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 17 (suppl) 171-171, 2012.
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P-17 A tiered in vitro approach to predict phototoxic potential
Sakiko Aizawa, Noriyasu Imai, Takuji Masunaga
Fundamental Res. Lab., KOSE Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 171-171, 2012.
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P-18 Reactive Oxygen Species (ROS) assay to assess photosafety of pharmaceuticals -JaCVAM multicenter validation studies-
Yumiko Iwase1, Toshinobu Yamamoto1, Shinobu Wakuri2, Satomi Onoue3, Yoshiki Seto3, Naoto Osaki4, Hironori Takagi4, Tsuguto Toda5, Kazuichi Nakamura5, Yasuhiro Matsumoto6, Satoru Kawakami7, Kazuhiro Hosoi8, Hajime Kojima9,10
1Mitsubishi Tanabe Pharma Corporation, 2Food and Drug Safety Center, 3University of Shizuoka, 4Taisho pharmaceutical Co.Ltd., 5Shionogi & Co.Ltd., 6Aska Pharmaceutical Co.Ltd., 7Asahi Kasei Pharma Corporation, 8Santen Pharmaceutical Co.Ltd., 9National Institute of Health Sciences, 10Japanese Center for the Validation of Alternative Methods (JaCVAM)
Alternatives to Animal Testing and Experimentation 17 (suppl) 172-172, 2012.
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P-19 Investigation of phototoxicity test using human ES cell-derived retinal pigment epithelium
Satoshi Ando, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 172-172, 2012.
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P-20 Development of in vitro method for neurotoxicity using neuronal cell derived from mouse embryonic stem cells
Kumiko Kobayashi, Noriyuki Suzuki, Atsushi Kuwahara, Satoshi Ando, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 173-173, 2012.
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P-21 Development of an alternative test for embryotoxicity using embryonic stem cell differentiation into neural cells in vitro
Noriyuki Suzuki, Norihisa Yamashita, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 174-174, 2012.
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P-22 Availability of silkworm as an animal model of drug-induced tissue injury
Yoshinori Inagaki1, Yasuhiko Matsumoto1, Hiroshi Hamamoto1, Keiko Kataoka2, Naoya Matsuhashi2, Takuya Sugita3, Takuro Ueki3, Hidenobu Okumura3, Kazuhisa Sekimizu1,2
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2Genome Pharmaceuticals Institute Co.,Ltd., 3Tokiwa Pharmaceutical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 175-175, 2012.
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P-23 Development of an alternative method of acute oral toxicity tests using silkworm
Takuya Sugita1, Takuro Ueki1, Hiroshi Hamamoto2, Yasuhiko Matsumoto2, Kazuhisa Sekimizu2, Hidenobu Okumura1
1Tokiwa pharmaceutical Co.,Ltd, 2Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 17 (suppl) 175-175, 2012.
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P-24 Study on administration methods in an alternative method of acute oral toxicity tests using silkworms
Takuro Ueki1, Takuya Sugita1, Hiroshi Hamamoto2, Yasuhiko Matsumoto2, Kazuhisa Sekimizu2, Hidenobu Okumura1
1Tokiwa pharmaceutical Co.,Ltd., 2Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
Alternatives to Animal Testing and Experimentation 17 (suppl) 176-176, 2012.
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P-25 A genotoxicity test based on p53R2 gene expression in human cells (NESMAGET, Part13). -Establishment of stable cell line-
Taisei Mizota, Katsutoshi Ohno, Toshihiro Yamada
Food Safety Research Institute, Nissin Foods Holdings Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 176-176, 2012.
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P-26 An in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expresslon -Improved method to increase throughput-
Hideki Maeshima, Katsutoshi Ohno, Mina Ito, Toshihiro Yamada
Food Safety Research Institute, Nissin Foods Holdings Co.,Ltd.
Alternatives to Animal Testing and Experimentation 17 (suppl) 177-177, 2012.
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P-27 Equality of 6-well method and 96-well method in the Bhas 42 cell transformation assay -From the results of international validation studies-
Ayako Sakai, Kiyoshi Sasaki, Nobuko Endou, Shojiro Yamazaki, Makoto Umeda, Noriho Tanaka
Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 17 (suppl) 178-178, 2012.
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P-28 Effects of parasympathetic nervous system on the myocardial ischemia/reperfusion injury-induced cell apoptosis.
Hideto Ariumi1, Takahito Sonobe1, Yuji Yoshiyama1
1Division of Community Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmacy, Kitasato University
Alternatives to Animal Testing and Experimentation 17 (suppl) 179-179, 2012.
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P-29 Effects of foruskolin (FRK) on cultured rat embryos
Yokoyama A1, Akita M2
1Kanagawa Life-sciense Research, 2Kamakura Women's University
Alternatives to Animal Testing and Experimentation 17 (suppl) 179-179, 2012.
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P-30 Effects of α-ripo acid (ARA) on cultured rat embryos
Yokoyama A1, Akita M2
1Kanagawa Life-sciense Research, 2Kamakura Women's University
Alternatives to Animal Testing and Experimentation 17 (suppl) 180-180, 2012.
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P-31 Effects of lutein (LTN) on cultured rat embryos
Yokoyama A1, Akita M2
1Kanagawa Life-sciense Research, 2Kamakura Women's University
Alternatives to Animal Testing and Experimentation 17 (suppl) 180-180, 2012.
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P-32 An in vitro investigation of cytotoxicity of diclofenac acyl glucuronide
Taishi Miyashita, Kento Kimura, Shinya Endo, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi
Faculty of Pharmaceutical Sciences, Kanazawa University
Alternatives to Animal Testing and Experimentation 17 (suppl) 181-181, 2012.
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P-33 Biliary metabolites and gene expression in hepatic tissue on gas-permeable membrane and micropatterned collagen gel.
Hitoshi Matsui1, Shoji Takeuchi2, Tomoharu Osada3, Teruo Fujii2, Yasuyuki Sakai2
1BEANS Laboratory, 2University of Tokyo, Institute of Industrial science, 3Mitsubishi Chemical Medience Corporation
Alternatives to Animal Testing and Experimentation 17 (suppl) 181-181, 2012.
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P-34 Estimation of the contribution of CYP isozymes in the metabolism of repaglinide
Aya Matsubara1, Eri Hotta1, Toshiyuki Kudo1, Yuka Oya1, Ryo Tanaka1, Seina Komatsu1, Yuichi Sugiyama2, Kiyomi Ito1
1Faculty of Pharmaceutical Sciences, Musashino University, 2RIKEN Innovation Center, RIKEN
Alternatives to Animal Testing and Experimentation 17 (suppl) 182-182, 2012.
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P-35 Development of in silico prediction model for CYP3A4 inhibition by using gene expression Programming
Atsuto Fujita1, Fumiyoshi Yamashita1, Mitsuru Hashida1,2
1Graduate School of Pharmaceutical Sciences, Kyoto University., 2Institute for Integrated Cell-Material Sciences, Kyoto University.
Alternatives to Animal Testing and Experimentation 17 (suppl) 182-182, 2012.
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P-36 Structure Activity Relationship Analysis for Discriminating P-glycoprotein Substrates
Yoshida S1, Yamashita F1, Ose A3, Maeda K3, Sugiyama Y4, Hashida M1,2
1Graduate School of Pharmaceutical Sciences, 2Institute for Integrated Cell-Material Sciences, Kyoto University., 3Graduate School of Pharmaceutical Sciences, The University of Tokyo., 4Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Alternatives to Animal Testing and Experimentation 17 (suppl) 183-183, 2012.
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P-37 Analysis of the in vivo function of a BCRP variant (ABCG2 421C>A) by using a mathematical model for intestinal absorption
Yuta Tanaka1, Yoshiaki Kitamura1, Kazuya Maeda2, Yuichi Sugiyama3
1Discovery Research Laboratories, Kyorin Pharmaceutical Co.Ltd., 2Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3Sugiyama Laboratory, RIKEN (The Institute of Physical and Chemical Research)
Alternatives to Animal Testing and Experimentation 17 (suppl) 183-183, 2012.
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P-38 Evaluation of the binding of corticosterone to OCT3 -utilization for finding OCT3 inhibitors-
Yasuka Aoki, Katsuhisa Inoue, Tomoya Yasujima, Kinya Ohta, Hiroaki Yuasa
Graduate School of Pharmaceutical Sciences, Nagoya City University
Alternatives to Animal Testing and Experimentation 17 (suppl) 184-184, 2012.
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P-39 Investigation of the urinary excretion mechanisms of cationic drugs (beta-blockers and triptans)
Tomoko Kito1, Yuichi Sugiyama2, Hiroyuki Kusuhara1
1Faculty and Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2RIKEN Research Cluster for Innovation
Alternatives to Animal Testing and Experimentation 17 (suppl) 184-184, 2012.
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P-40 Prediction of blood-brain barrier permeability of cationic drugs in human using a human brain capillary endothelial cell line hCMEC/D3
Takashi Okura1, Keita Shimomura1, Kei Higuchi1, Pierre-Oliver Couraud2, Yoshiharu Deguchi1
1School of Pharmaceutical Sciences, Teikyo University, 2INSERM U1016
Alternatives to Animal Testing and Experimentation 17 (suppl) 185-185, 2012.
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P-41 Cytoprotective properties of hypotaurine by scavenging hydroxyl radicals within TR-TBT 18d-1 cells used as an in vitro placental barrier model
Mariam Duereh1, Tomohiro Nishimura1, Yuki Sugita1, Kei Higuchi1, Masatoshi Tomi1, Emi Nakashima1
1Faculty of Pharmaceutical, Keio University, 2Faculty of Pharmaceutical Sciences, Teikyo University
Alternatives to Animal Testing and Experimentation 17 (suppl) 185-185, 2012.
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P-42 Utilization of human placental plasma membrane vesicles for studying drug transport mechanisms at the placental barrier
Tomohiro Tawara1, Hiromi Eguchi1, Tomohiro Nishimura1, Tetsuo Maruyama2, Masatoshi Tomi1, Emi Nakashima1
1Faculty of Pharmacy, Keio University, 2School of Medicine, Keio University
Alternatives to Animal Testing and Experimentation 17 (suppl) 186-186, 2012.
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P-43 Acute-phase protein Alpha-1-acid Glycoprotein Acquires Antibacterial Activity through S-nitrosation by a Nitric oxide-dependent mechanism
Kaori Watanabe1, Yu Ishima1,2, Teruo Kuroda3, Wakano Ogawa3, Hiroshi Watanabe1,2, Masaki Otagiri1,4,5, Toru Maruyama1,2
1Grad Sch of Pharm Sci, Kumamoto Univ, 2Ctr for Clin Pharm Sci, Sch of Pharm, Kumamoto Univ, 3Grad Sch of Med, Dent and Pharm Sci, Okayama Univ, 4Faculty of Pharm Sci, Sojo Univ, 5DDS Res Inst, Sojo Univ
Alternatives to Animal Testing and Experimentation 17 (suppl) 186-186, 2012.
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P-44 Investigation of evaluation method for epithelial irritation with intracellular calcium level
Manami Mitsuyama, Toru Tanaka, Hiroaki Todo, Kenji Sugibayashi
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 17 (suppl) 187-187, 2012.
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P-45 Establishment of a simple screening method for skin permeation enhancers using liposomes
Yuki Kitao, Hiroaki Todo, Kenji Sugibayashi
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 17 (suppl) 187-187, 2012.
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P-46 Development of modified ROS assay system for photosafety evaluation
Gen Suzuki, Masashi Kato, Satomi Onoue, Shizuo Yamada
School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 17 (suppl) 188-188, 2012.
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