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Alternatives to Animal Testing and Experimentation 20巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN（オンライン）
2185-4726
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開始頁
Current Problems and Perspectives of the Alternate Test Methods from the Viewpoint of in vivoToxicology
Jun Kanno
Division of Cellular & Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 108-108, 2015.
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International Trend in Animal Welfare
Tsutomu Miki Kurosawa
Kagoshima University
Alternatives to Animal Testing and Experimentation 20 (suppl) 108-108, 2015.
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S1-1 OECD adverse outcome pathway (AOP) for skin sensitization and development of AOP for immunotoxicity of chemicals
Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 20 (suppl) 109-109, 2015.
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S1-2 Validation tests of IL-8 Luc assay
Yutaka Kimura
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 20 (suppl) 109-109, 2015.
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S1-3 Validation study and the draft guideline of h-CLAT
Takao Ashikaga
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 110-110, 2015.
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S1-4 Development of a novel skin sensitization test applicable to lipophilic chemicals - The utility of the EpiSensA with a three-dimensional human skin model -
Kazutoshi Saito
Kao Corporation, R & D Safety Science Research
Alternatives to Animal Testing and Experimentation 20 (suppl) 110-110, 2015.
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S2-1 Assessing the risk of chemical compounds mediating CSC generation employing an iPS model
Tomonari Kasai, Saki Sasada, Kenta Hoshikawa, Takuma Matsumoto, Junko Masuda, Anna Sanchez Calle, Arun Vaidyanath, Takayuki Kudoh, Masaharu Seno
Laboratory of Nano-Biotechnology, Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University
Alternatives to Animal Testing and Experimentation 20 (suppl) 111-111, 2015.
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S2-2 New approach for the prediction of repeated-dose toxicity
Kouichi Yoshinari
Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 20 (suppl) 111-111, 2015.
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S2-3 Development of a novel method for in vitro assessment of chemical respiratory sensitizers
Takayuki Yoshimoto, Yukino Chiba, Ren Tsunoda, Mingli Xu, Izuru Mizoguchi
Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University
Alternatives to Animal Testing and Experimentation 20 (suppl) 112-112, 2015.
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S3-1 Development of Scaffold-free 3D Tissue & Organ Fabrication by Bio-3D Printer
Koichi Nakayama
Department of Regenerative Medicine and Biomedical Engineering, Faculty of Medicine, Saga University
Alternatives to Animal Testing and Experimentation 20 (suppl) 113-113, 2015.
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S3-2 Development of microfluidic biochips in predictive toxicology and applied pharmacology
Eric Leclerc
Laboratory for Integrated Micro Mechatronic Systems, Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 20 (suppl) 113-113, 2015.
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S4-1 The strategy for assessing systemic toxicity of cosmetic ingredients
Akiko Tamura
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 114-114, 2015.
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S4-2 Strategy to establish in vitro liver toxicity assay systems for cosmetics
Kousei Ito, Shuichi Sekine
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 20 (suppl) 114-114, 2015.
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S4-3 Approach to the Reproductive and Developmental Toxicity Assessment for Cosmetic Ingredients
Tomoka Hisaki
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 115-115, 2015.
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S5-1 Approval of Short Time Exposure (STE) Test as OECD Test Guideline
Masaaki Miyazawa
Kao Corporation, R & D Safety Science Research
Alternatives to Animal Testing and Experimentation 20 (suppl) 116-116, 2015.
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S5-2 Trend on validation study of SIRC-CVS : TEA test as an alternative method for evaluating eye irritation
Shigenobu Hagino
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 116-116, 2015.
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S5-3 Validation study of Vitrigel-EIT (Eye Irritancy Test) method
Hiroyuki Yamaguchi1),2), Toshiaki Takezawa1)
1)National Institute of Agrobiological Sciences, 2)Kanto Chemical Co. , Inc.
Alternatives to Animal Testing and Experimentation 20 (suppl) 117-117, 2015.
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S6-1 Functional adenohypophysis generated in three-dimensional culture of human ES cells
Hidetaka Suga
Nagoya University Hospital, Department of Endocrinology and Diabetes, Clinical Assistant Prof
Alternatives to Animal Testing and Experimentation 20 (suppl) 118-118, 2015.
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S6-2 Investigation of intractable diseases utilizing disease-specific iPS cells
Keiko Muguruma
Laboratory for Cell Asymmetry, RJKEN Center for Developmental Biology
Alternatives to Animal Testing and Experimentation 20 (suppl) 118-118, 2015.
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S6-3 Generation of a ciliary margin-like stem cell niche from self-organizing human ESC-derived retinal tissue
Atsushi Kuwahara1),2),3),4), Chikafumi Ozone1), Tokushige Nakano1),2), Koichi Saito2), Mototsugu Eiraku4), Yoshiki Sasai1)
1)Laboratory for Neurogenesis and Organogenesis, RIKEN Center for Developmental Biology, 2)Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 3)Regenerative & Cellular Medicine Office, Sumitomo Dainippon Pharma Co., Ltd, 4)Laboratory for In Vitro Histogenesis, RIKEN Center for Developmental Biology
Alternatives to Animal Testing and Experimentation 20 (suppl) 118-118, 2015.
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S7-1 Outline of a plan for Japanese Project "ARCH-Tox" for the Future Chemicals Management Policy : Research and Development of in vitro and in vivo Assays for Internationally Leading Hazard Assessment and Test Methods
Hajime Kojima
Div. of Risk Assessment, Biological Safety Research Center (BSRC), National Institute of Health Sciences (NIHS)
Alternatives to Animal Testing and Experimentation 20 (suppl) 119-119, 2015.
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S7-2 Mechanism-based evaluation system for chemical toxicity using gene expression analysis
Fumiyo Saito
Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI)
Alternatives to Animal Testing and Experimentation 20 (suppl) 119-119, 2015.
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S7-3 Challenge to short-term prediction for chemical carcinogenicity by gene expression analysis
Hiroshi Matsumoto
Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute (CERI)
Alternatives to Animal Testing and Experimentation 20 (suppl) 120-120, 2015.
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S7-4 Establishment of comprehensive evaluation method on neurotoxicity targeting neurogenesis and gliogenesis
Makoto Shibutani
Dept. of Veterinary Medicine, Faculty of Agriculture, Graduate School, Institute of Agricultural Science, Tokyo University of Agriculture and Technology
Alternatives to Animal Testing and Experimentation 20 (suppl) 120-120, 2015.
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S7-5 Development of cell-based assay system using artificial chromosome vector and bioluminescent reporters
Yoshihiro Nakajima
Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 20 (suppl) 121-121, 2015.
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S7-6 In vitro nephrotoxicity assays using mammalian artificial chromosome vector
Tetsuya Ohbayashi1), Shinji Kitamura2), Mitsuo Oshimura3)
1)Research Center for Bioscience and Technology, Tottori University, 2)Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine hromosome, 3)Chromosome Engineering Research Center, Tottori University
Alternatives to Animal Testing and Experimentation 20 (suppl) 121-121, 2015.
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S7-7 In vitro hepatotoxicity assay using the primary cells of transgenic mouse hepatocyte
Kohji Yamakage
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 122-122, 2015.
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S7-8 In vitro neurotoxicity assays using mouse embryonic stem cells
Kumiko Kobayashi, Noriyuki Suzuki, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
Alternatives to Animal Testing and Experimentation 20 (suppl) 122-122, 2015.
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M-1 Development of the prediction method for repeated-dose toxicity of chemical compounds based on the statistical data analysis using in vivo toxicity database and in vitro assays
Kouichi Yoshinari
Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 20 (suppl) 123-123, 2015.
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M-2 Establishment on in vitro culture system mimicking organisms by co-culture of hepatic progenitor cell line HepaRG and stellate cell
Seiichi Ishida
Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 123-123, 2015.
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M-3 Prediction of the risk of drug-induced cholestasis based on the functional evaluatien of bile canalicular transporters in vitro
Takashi Yoshikado, Yuichi Sugiyama
Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Alternatives to Animal Testing and Experimentation 20 (suppl) 124-124, 2015.
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M-4 Development of universal method in skin stimulus measurement using epidermal keratinocyte mitochondria as a forefront of sensory system for homeostasis maintenance - Feasibility study -
Toshihiro Ona1),2), Junko Shibata1),2)
1)Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 2)O'Atari Inc.
Alternatives to Animal Testing and Experimentation 20 (suppl) 125-125, 2015.
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I-1 Current situation of Alternatives in USA and WC10
Thomas Hartung
Johns Hopkins University, School of Public Health, Center for Alternatives to Animal Testing, Doerenkamp- Zbinden Chair for Evidence-based Toxicology
Alternatives to Animal Testing and Experimentation 20 (suppl) 126-126, 2015.
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I-2 Advanced alternative test using mouse and human embryonic stem cells
Eui-Bae Jeung
Laboratory of Veterinary Biochemistry and Molecular Biology, Chungbuk National University
Alternatives to Animal Testing and Experimentation 20 (suppl) 127-127, 2015.
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I-3 Progress of Alternative Methods for Drug Safety Evaluation in China
Jufeng Wang, Zhengming He, Bo Li
National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug
Alternatives to Animal Testing and Experimentation 20 (suppl) 127-127, 2015.
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I-4 3Rs Initiatives in IndiaOpportunities and Challenges
Mohammad A.Akbarsha
Mahatma Gandhi-Doerenkamp Center (MGDC) for Alternatives, Bharathidasan University
Alternatives to Animal Testing and Experimentation 20 (suppl) 128-128, 2015.
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I-5 International Trend in 3Rs
Tsutomu Miki Kurosawa
Kagoshima University
Alternatives to Animal Testing and Experimentation 20 (suppl) 128-128, 2015.
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P-1 Evaluation of eye irritancy with a combination of Vitrigel-EIT (Eye Irritancy Test) method and Short Time Exposure (STE) method
Takeru Niitsuma, Yuzuki Nakagawa, Hiroko Okutomi, Miwako Kobayashi, Mayu Ikezumi, Yuko Matayoshi, Mika Watanabe
Hatano Research Institute Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 130-130, 2015.
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P-2 A novel statistical strategy for improving the predictive performance of Vitrigel-EIT (Eye Irritancy Test) method
Takuto Nakayama1),2), Takashi Sozu1), Hiroyuki Yamaguchi2),3), Toshiaki Takezawa2), Hajime Kojima4)
1)Tokyo University of Science, 2)National Institute of Agrobiological Sciences, 3)Kanto Chemical Co., Inc.,, 4)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 130-130, 2015.
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P-3 Evaluation of Mild Irritant Based on the Pathological Findings on the Cornea in the Bovine Corneal Opacity and Permeability Test (BCOP Test, an Alternative Method of Eye Irritation Test)
Masatoshi Furukawa1), Takashi Sakakibara1), Kouta Itoh1), Satoshi Sasaki1), Miharu Koshita1), Sohei Okumura1), Kohtaro Kawamura1), Masao Matsuura1), Hajime Kojima2)
1)Safety Research Institute for Chemical Compounds, Co., Ltd,, 2)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 131-131, 2015.
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P-4 Study on eye irritation test method using the three-dimensional reconstructed corneal model created using immortalized human corneal epithelial cell line (iHCE-NY) - Estimation of the reversibility by continuous culture after application of substances
Yoshinao Kato1), Naoki Yamamoto2), Atsushi Sato1), Satoru Nakata1), Hajime Kojima3)
1)Research Institutes, Nippon Menard Cosmetic Co., Ltd., 2)Fujita Health University Joint Research Laboratory, 3)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 132-132, 2015.
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P-5 Analysis of proteins by the two-dimensional electrophoresis in the new three-dimensional reconstructed cultured human corneal model (3D-iHCE-NYH model)
Yosuke Mano1), Yuko Matsui1), Yuji Aoki1), Noriko Hiramatsu2), Hiromi Yamashita2), Naoki Yamamoto2)
1)General Research and Development Institute, Hoyu Co., Ltd., 2)Laboratory of Morecular Biology, Institute of Joint Research, Fujita Health University
Alternatives to Animal Testing and Experimentation 20 (suppl) 133-133, 2015.
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P-6 Effect of Long Term Shipping on the EpiOcular TM Eye Irritation Test (EIT)
Yuki Handa1), Yulia Kaluzhny2), Helena Kandarova3)
1)Bio-Medical Department, KURABO INDUSTRIES LTD., 2)MatTek Corporation, 3)MatTek In Vitro Life Science Laboratories
Alternatives to Animal Testing and Experimentation 20 (suppl) 133-133, 2015.
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P-7 Working Group's Report - Alternative Primary Irritation Test
Mariko Sugiyama, Hidefumi Ikeda, Noriyasu Imai, Takashi Omori, Hiroaki Todo, Akemi Toyoda, Shigenobu Hagino, Kenji Sugibayashi
Working Group on alternative primary irritation test, Japanese Society of Alternatives to Animal Experiments (JSAAE)
Alternatives to Animal Testing and Experimentation 20 (suppl) 134-134, 2015.
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P-8 A proposal of test design for the 24 hours irritation patch test using information of 4 hours-result
Takashi Omori1), Hidefumi Ikeda1), Noriyyasu Imai1), Wakako Otsuka2), Hiroaki Todo1), Akemi Toyoda1), Shigenobu Hagino1), Kenji Sugibayashi1), Mariko Sugiyama1)
1)Special committee on alternative primary irritation test, Japanese Society of Alternatives to Animal Experiments (JSAAE), 2)Faculty of Culture and Information Science, Doshisha University
Alternatives to Animal Testing and Experimentation 20 (suppl) 134-134, 2015.
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P-9 Evaluation for skin irritation based on surfactant-induced membrane dynamics
Shinji Shimokawa, Naofumi Shimokawa, Yoshio Tsujino, Masahiro Takagi
Japan Advanced Institute of Science and Technology
Alternatives to Animal Testing and Experimentation 20 (suppl) 135-135, 2015.
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P-10 The utility of the TRP channels to evaluate sensory irritation
Masayuki Takaishi1), Fumitaka Fujita1), Hiroshi Matsui1), Tadashi Shimada1), Shizuka Iwashita1), Kiyomi Yoshikawa1), Yoshiro Suzuki2), Kunitoshi Uchida2), Makoto Tominaga2)
1)Mandom Corporation, 2)Okazaki Institute for Integrative Biosciences, National Institute for Physiological Sciences, National Institutes of Natural Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 135-135, 2015.
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P-11 Condition Setting of In vitro Percutaneous Absorption Method by the OECD guideline 428
Seo Ji Eun, Bae Hwan Kim
Keimyung University
Alternatives to Animal Testing and Experimentation 20 (suppl) 136-136, 2015.
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P-12 Skin sensitization model based by qualitative structure-toxicity relationships (QSTR) approach based on EC3 of LLNA
Kazuhiro Sato1), Jose Martin Ciloy2), Yukinori Kusaka1)
1)Department of Environmental Health, School of Medicine, University of Fukui, 2)Fujitsu Kyushu Systems Limited
Alternatives to Animal Testing and Experimentation 20 (suppl) 136-136, 2015.
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P-13 Inter-lab reproducibility of alternative skin sensitization test method using vitrigel chamber (Vitirgel-SST method)
Tadashi Uchino1), Hiroshi Miyazaki2), Kunihiko Yamashita2), Hajime Kojima1), Toshiaki Takezawa3), Takumi Akiyama1)
1)National Institute of Health Sciences, 2)Daicel Corporation, 3)National Institute of Agrobiological Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 137-137, 2015.
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P-14 Evaluation of skin sensitizer by a novel skin sensitization test using collagen vitrigel membrane chambers (Part 2)
Hiroshi Miyazaki1), Kunihiko Yamashita1), Tadashi Uchino2), Toshiaki Takezawa3), Hajime Kojima2)
1)Daicel Corporation, 2)National Institute of Health Sciences, 3)National Institute of Agrobiological Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 138-138, 2015.
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P-15 Intra- / inter-laboratory reproducibility of in vitro skin sensitization assay : Epidermal sensitization Assay (EpiSensA)
Mayu Ikezumi1), Hiroko Okutomi1), Asami Umetsu1), Hiroko Motohashi1), Mika Watanabe1), Megumi Sakuma2), Midori Takeyoshi2), Noriyasu Imai2), Kazutoshi Saito2), Hideyuki Mizumachi3), Masaaki Miyazawa3)
1)Hatano Research Institute, Food and Drug Safety Center, 2)KOSE Corporation, Fundamental Research Laboratories, 3)Kao Corporation, R & D Safety Science Research
Alternatives to Animal Testing and Experimentation 20 (suppl) 139-139, 2015.
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P-16 Investigation on the effects of oxidative stress on allergic response using the h-CLAT
Ayano Suzuki, Minori Mezaki, Hiroshi Itagaki
Yokohama National University
Alternatives to Animal Testing and Experimentation 20 (suppl) 139-139, 2015.
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P-17 Reducing false-negatives in the in vitro testing of chemicals for skin sensitization : LP solvent exposure method for phthalic anhydride P
Kazuto Narita1), Thihong Phuc Vo1), Fumiko Nakagawa1), Hiroshi Itagaki1), Hajime Kojima2)
1)Yokohama National University, 2)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 140-140, 2015.
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P-18 New risk assessment of skin sensitization on low exposure of ingredients using dermal sensitization threshold
Yuuki Ootsubo, Taku Nishijo, Kazutoshi Saito, Masaaki Miyazawa, Hitoshi Sakaguchi
Kao Corporation, R & D-Safety Science Research
Alternatives to Animal Testing and Experimentation 20 (suppl) 140-140, 2015.
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P-19 Development of an in vitro test for allergenic potency of proteins
Hanae Tsukumo1), Natsumi Matsunari1), Hajime Kojima2), Hiroshi Itagaki1)
1)Yokohama National University, 2)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 141-141, 2015.
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P-20 The feasibility of technology transfer of In vitro sensitization test, SH test
Midori Takeyoshi1), Sakiko Aizawa1), Noriyasu Imai1), Maki Sugiyama2), Akemi Toyoda2), Morihiko Hirota3)
1)KOSE Corporation, Fundamental Research Laboratories, 2)POLA Chemical Industries, Inc., Quality Research Department, 3)Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 141-141, 2015.
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P-21 Skin sensitization prediction for surfactants using two in chemico alternatives and clarification of characterization for these assays
Yusuke Yamamoto1), Toshihiko Kasahara1), Yoshihiro Jimbo3), Yasuhiro Kotuku1), Takanori Hioki2), Masaharu Fujita1)
1)Safety Evaluation Center, Ecology & Quality Management Division, CSR Division, FUJIFILM Corporation, 2)Ecology & Quality Management Division, CSR Division, FUJIFILM Corporation, 3)Synthetic Organic Chemistry Lavoratories, R & D Management Headquarters, FUJIFILM Corporation
Alternatives to Animal Testing and Experimentation 20 (suppl) 142-142, 2015.
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P-22 Evaluation reactivity of the cysteinecontaining peptide and sensitizers using spectrophotometer
Hiroshi Miyazaki1), Kenji Usui2), Kunihiko Yamashita1)
1)Daicel Corporation, 2)Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University
Alternatives to Animal Testing and Experimentation 20 (suppl) 142-142, 2015.
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P-23 Thymic stromal lymphopoietin is induced by protein and chemical allergens in cultured human keratinocytes
Yasutaka Kuroda1),2), Takuo Yuki1), Yutaka Takahashi1), Hiroshi Itagaki2)
1)Safety Science Research Laboratories, Kao Corporation, 2)Department of Material Science and Engineering, Faculty of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 20 (suppl) 143-143, 2015.
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P-24 Effect of reactive oxygen species quenchers on in vitro photoallergenicity evaluation
Akemi Toyoda1),2), Hiroshi Itagaki2)
1)Quality Research Department, POLA Chemical Industries, INC, 2)Depertment of Materials Science and Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 20 (suppl) 143-143, 2015.
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P-25 Development of in vitro photogenotoxic risk assessment tools with the use of DNA intercalating dyes
Yoshiki Seto, Masanori Ochi, Ami Oishi, Satomi Onoue
Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 20 (suppl) 144-144, 2015.
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P-26 DNA microarray analysis using UVB-irradiated reconstructed human epidermis
Kenji Shimizu1), Naoyuki Togawa2), Yuki Yamashita3), Daisuke Yoshida1)
1)Nikkol group Cosmos Technical Center Co., Ltd., 2)Yokohama Research Laboratories, Mitsubishi Rayon Co., Ltd., 3)Nikkol Group Nikoderm Reseach Inc.
Alternatives to Animal Testing and Experimentation 20 (suppl) 145-145, 2015.
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P-27 Safety evaluation method of soft contact lens which adsorbed eyewash solution ingredient using rabbit corneal epithelium cells
Miho Tanaka, Manabu Nozaki, Maki Nakamura, Hiroko Yano
KOBAYASHI Pharmaceutical Co., Ltd.
Alternatives to Animal Testing and Experimentation 20 (suppl) 145-145, 2015.
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P-28 New 1h phenotypic screening allows efficacy and toxicity evaluation for anti-pancreatic cancer agaisnt extract of sprout-forcing grape seeds
Toshihiro Ona1),2), Junko Shibata1),2), Akio Hayakawa3), Tsukasa Nagao4)
1)Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 2)O'Atari Inc., 3)Kohkan Pharmaceutical Institute Co., Ltd., 4)Japan Biomedicine Co., Ltd.
Alternatives to Animal Testing and Experimentation 20 (suppl) 146-146, 2015.
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P-29 Expression of drug resistance phenomena by 3D culture of human hepatoma cells with Cellbed 3D culture and its application to the agent screening for overcoming drug resistance
Yuya Ohta1), Takahiro Mizutami1), Yuji Komizu1), Takuya Iwasa2), Kouhei Sasaki2), Rie Watanabe2), Masaaki Kawabe2), Taku Matsushita1)
1)Department of Applied Life Science, Sojo University, 2)Central Research Laboratory, Japan Vilene Company, Ltd.
Alternatives to Animal Testing and Experimentation 20 (suppl) 146-146, 2015.
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P-30 Development of a simple risk assessment of chemical compounds in the induction of Cancer stem cells in vitro
Saki Sasada, Kenta Hoshikawa, Takuma Matsumoto, Anna Sanchez Calle, Arun Vaidyanath, Junko Masuda, Tomonari Kasai, Masaharu Seno
Graduate School of Natural Science and Technology, Okayama University
Alternatives to Animal Testing and Experimentation 20 (suppl) 147-147, 2015.
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P-31 Construction of in vitro assay for drug induced mitochondrial fatty metabolism injury by circumventing crabtree effect
Kumiko Oizumi1), Shuichi Sekine1), Morihiko Hirota2), Akiko Tamura2), Nana Kuwata2), Hirokazu Kouzuki2), Kousei Ito1)
1)The Laboratory Biopharmaceutics, Graduate School of Pharmaceutical Sciences, 2)Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 147-147, 2015.
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P. 32 Assessment of Mitochondrial Dysfunction causes Drug-Induced Hepatotoxicity in rat sandwich-cultured hepatocyts
Moemi Kawaguchi, Cong Liu, Shuichi Sekine, Kousei Ito
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 20 (suppl) 148-148, 2015.
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P-33 A culture method of rat hepatocytes with a three-dimensional cell culture scaffold/Cellbed, and application for liver toxicity testing.
Takuya Iwasa1), Rie Watanabe1), Kouhei Sasaki1), Taku Matsushita2), Masaaki Kawabe3), Akihiro Yamaguchi1)
1)Central Research Laboratory, Japan Vilene Company, Ltd., 2)Department of Applied Life Science, Faculty of Biotechnology and Life Science, Sojo University, 3)Primary Cell Division, Cosmo Bio Company, Ltd.
Alternatives to Animal Testing and Experimentation 20 (suppl) 148-148, 2015.
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P-34 Construction of the novel system of the liver injury risk based on liver bile canalicular formation
Akinori Takemura, Aya Izaki, Shuichi Sekine, Kousei Ito
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 20 (suppl) 149-149, 2015.
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P-35 Prediction of the Clinical Risk of DrugInduced Cholestatic Liver Injury Using Human Sandwich Cultured Hepatocytes
Takeshi Susukida1), Shuichi Sekine1), Mayuka Nozaki1), Mayuko Tokizono1), Morihiko Hirota2), Akiko Tamura2), Nana Kuwata2), Yuichi Kouzuki2), Kousei Ito1)
1)Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 2)Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 149-149, 2015.
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P-36 An attempt to establish a framework for evaluation of hepatotoxicity by combining in silico and in vitro approaches
Yuko Nukada, Yuichi Ito, Mizuki Sone, Hiroto Bushita, Shujie Liu, Junko Ohuchi, Naohiro Nishiyama
Kao Corporation
Alternatives to Animal Testing and Experimentation 20 (suppl) 150-150, 2015.
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P-37 Evaluation of mouse primary hepatocyte 2D culture by Cyp gene expression and cytotoxicity
Kiyoshi Sasaki, Shinobu Wakuri, Maiko Gondo, Nobuko Endo, Hajime Sui, Kohji Yamakage
Division of Alternative Toxicology Test, Hatano Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 150-150, 2015.
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P-38 In vitro developmental neurotoxicity testing using human multipotent cells
Miki Asanagi1), Shigeru Yamada2), Naoya Hirata2), Hiroshi Itagaki1),2), Yuko Sekino2), Yasunari Kanda2)
1)Graduate School of Engineering, Yokohama National University, 2)Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 151-151, 2015.
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P-39 Study of in vitro embryotoxicity testig by differentiation of ES-D3 cells using glass fiber
Koichi Imai, Tsubasa Shirai
Department of Biomaterials, Osaka Dental University
Alternatives to Animal Testing and Experimentation 20 (suppl) 151-151, 2015.
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P-40 Study of in vitro embryotoxicity potential by two type nano titanium dioxide
Koichi Imai, Tsubasa Shirai
Department of Biomaterials, Osaka Dental University
Alternatives to Animal Testing and Experimentation 20 (suppl) 152-152, 2015.
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P-41 Advanced developmental toxicity test including the size of mEBs
Hee Young Kang, Choi Young Kwon, Hwang Jeong Ung, Eui Bae Jeung
Laboratory of Veterinary Biochemistry and Molecular Biology, Chungbuk National University
Alternatives to Animal Testing and Experimentation 20 (suppl) 152-152, 2015.
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P-42 The impact of progesterone on calcium signaling in differentiated mES cells into cardiomyocyte
Choi Young Kwon, Hee Young Kang, Eui Bae Jeung
Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University
Alternatives to Animal Testing and Experimentation 20 (suppl) 153-153, 2015.
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P-43 Effects of alpha-linolenic acid on cultured rat embryos
Masaharu Akita1), Atsushi Yokoyama2)
1)Faculty of Family and Consumer Sciences, Department of Nutrition Dietetics, Kamakura Women's University, 2)Kanagawa Life-Science Research
Alternatives to Animal Testing and Experimentation 20 (suppl) 153-153, 2015.
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P-44 Effects of Peucedanum japonicum on cultured rat embryos
Atsushi Yokoyama1), Masaharu Akita2)
1)Kanagawa Life-Science Research, 2)Faculty of Family and Consumer Sciences, Department of Nutrition Dietetics, Kamakura Women's University
Alternatives to Animal Testing and Experimentation 20 (suppl) 153-153, 2015.
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P-45 Specificity of Embryonic Stem Cell Tests to Cosmetic Ingredients
Tomoka Hisaki, Akiko Tamura, Shiho Oeda, Takao Ashikaga, Hirokazu Kouzuki
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 20 (suppl) 154-154, 2015.
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P-46 Evaluation of the effect of oxygen on hepatocyte differentiation protocol of human iPSCs utilizing oxygen permeable membrane
Keiichi Kimura1), Ikki Horiguchi1), Taketomo Kido3), Atsushi Miyajima3), Yasuyuki Sakai1),2)
1)Institute of industrial science, The University of Tokyo, 2)School of engineering, The University of Tokyo, 3)Institute of Molecular and Cellular Biosciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 20 (suppl) 154-154, 2015.
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P-47 3D tissue models using human iPS derived hepatocytes
Junji Fukuda
Yokohama National University
Alternatives to Animal Testing and Experimentation 20 (suppl) 155-155, 2015.
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P-48 Adhesion of pancreatic cancer cells in a liver microvasculature model using an in-vitro coculture model
Mathieu Danoy1),2),3), Marie Shinohara2), Astia Safitri Rizki2), Dominique Callard1), Vincent Senez3), Yasuyuki Sakai2)
1)LIMMS/CNRS-IIS UMI2820, 2)Institute of Industrial Science The University of Tokyo, 3)IEMN
Alternatives to Animal Testing and Experimentation 20 (suppl) 155-155, 2015.
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P-49 Formation of in Vitro Co-culture Model of Pulmonary Alveolus Using human epithelial cell line A549, human monocytic cell line THP1, and human umbilical vein cells HUVEC for Prediction Study of Nanoparticle Permeation
Xinying Xu, Ayaka Uemura, Kikuo Komori, Yasuyuki Sakai
University of Tokyo
Alternatives to Animal Testing and Experimentation 20 (suppl) 156-156, 2015.
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P-50 Establishment of in vitro culture system mimicking organisms by co-culture of hepatic progenitor cell line HepaRG and stellate cell
Seiichi Ishida1), Shinichiro Horiuchi1), Mitsuko Hara2), Yukie Kuroda1), Shoko Uchida1), Riho Ishida1), Suryang Kim1), Tomokazu Mastuura3), Fabrice Morel4), Anne Corlu4), Soichi Kojima2), Yuko Sekino1)
1)Division of Pharmacology, National Institute of Health Sciences, 2)RIKEN Center for Life Science. Technologies, 3)Department of Laboratory Medicine, The Jikei University, 4)INSERM U911
Alternatives to Animal Testing and Experimentation 20 (suppl) 156-156, 2015.
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P-51 A novel culture system for extrapolating the exeretion of drug metabolites in human liver : Co-culture of HepG2 cells (a hepatocellular carcinoma cell line) with activated hepatic function and bile canaliculus-like structures in a collagen vitrigel membra
Ayumi Oshikata, Toshiaki Takezawa
Division of Animal Sciences, National Institute of Agrobiological Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 157-157, 2015.
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P-52 Comparative metabolome analysis and toxicity test of cultured fetal and adult hepatocytes in humans (2nd Report)
Yudai Ichikawa1), Taku Matsushita1), Takaaki Ishii1), Yuji Komizu1), Su Ryang Kim2), Seiichi Ishida2), Atsuko Miyajima3), Yuko Sekino2)
1)Department of Applied Life Science, Sojo University, 2)Division of Pharmacology, National Institute of Health Sciences, 3)Division of Medical Devices, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 20 (suppl) 157-157, 2015.
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P-53 Maintenance culture of cryopreserved human hepatocytes using Cellbed as 3D scaffold
Takaaki Ishii1), Yuji Komizu1), Takuya Iwasa2), Kouhei Sasaki2), Rie Watanabe2), Masaaki Kawabe2), Taku Matsushita1)
1)Department of Applied Life Science, Sojo University, 2)Central Research Laboratory, Japan Vilene Company, Ltd.
Alternatives to Animal Testing and Experimentation 20 (suppl) 158-158, 2015.
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P-54 Vitrigel-Corneal Permeability Test (CPT) method : Evaluation of drug permeability utilizing corneal models fabricated in a collagen vitrigel membrane chamber
Hiroyuki Yamaguchi1),2), Toshiaki Takezawa1)
1)National Institute of Agrobiological Sciences, 2)Kanto Chemical Co., Inc.
Alternatives to Animal Testing and Experimentation 20 (suppl) 158-158, 2015.
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P-55 Similarities among chemicals based on gene expression data
Junichi Takeshita1), Ryosuke Abe2), Akinobu Toyoda2), Yasunori Endo2), Sadaaki Miyamoto2), Hidenori Tani3), Hiroshi Aoki3), Masaaki Torimura3), Hiroaki Sato3), Masashi Gamo1)
1)Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology, 2)Faculty of Systems and Information Engieering, University of Tsukuba, 3)Environmental Management Research Institute, National Institute of Advanced Industrial Science and Technology
Alternatives to Animal Testing and Experimentation 20 (suppl) 159-159, 2015.
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P-56 Use of a combination of three in silico models for better prediction of hepatotoxicity and understanding prediction property on hepatic lesion
Junko Ohuchi, Hidefumi Yamane, Toshio Kasamatsu, Yuichi Ito, Naohiro Nishiyama
R & D-Core technology-Safety Science Research, Kao Corporation
Alternatives to Animal Testing and Experimentation 20 (suppl) 159-159, 2015.
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P-57 The investigation of animal experiments in application documents for approval of drugs from the point of animal welfare
Akishige Fujisawa
incorporated non-profit organization ALIVE (All Life In a Viable Environment)
Alternatives to Animal Testing and Experimentation 20 (suppl) 160-160, 2015.
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