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Alternatives to Animal Testing and Experimentation 22巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN(オンライン)
2185-4726

書籍情報から探す
開始頁
Regulatory Science for realizing 3Rs in animal tests
Toru Kawanishi
National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 19-19, 2017.
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Validation and international acceptance of alternative methods : New ways forward
Chantra Eskes
SeCAM
Alternatives to Animal Testing and Experimentation 22 (suppl) 20-20, 2017.
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Trends of 3Rs in OECD and ICH
Akiyoshi Nishikawa
Biological Safety Research Center, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 20-20, 2017.
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The dilemma of animal welfare and the law concerning the welfare and control of animals
Masashi Norihisa
Animal Welfare and Management Office, Nature Conservation Bureau, Ministry of the Environment
Alternatives to Animal Testing and Experimentation 22 (suppl) 21-21, 2017.
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S1-1 Expectations and infrastructure improvement for Organs-on-a-chip as drug discovery tool
Seiichi Ishida
National Institute of Health Sciences Division of Pharmacology
Alternatives to Animal Testing and Experimentation 22 (suppl) 22-22, 2017.
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S1-2 Ogans-on-a-chip : anticipation of use for alternatives to animal experiments in chemical companies
Koichi Saito
Sumitomo Chemical Co., Ltd. Advanced Materials Development Laboratory
Alternatives to Animal Testing and Experimentation 22 (suppl) 22-22, 2017.
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S1-3 Technical challenges to industrialization of organs-on-a-chip
Shinji Sugiura, Toshiyuki Kanamori
National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 22 (suppl) 23-23, 2017.
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S1-4 Organs-on-a-chip biological problems to be solved
Naohiko Anzai1),2), Motoshi Ouchi2), Tomomi Furihata1)
1)Chiba University Graduate School of Medicine, 2)Dokkyo Medical University School of Medicine
Alternatives to Animal Testing and Experimentation 22 (suppl) 23-23, 2017.
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S2-1 Read-across within Regulatory Context
Yumi Akahori
Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 24-24, 2017.
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S2-2 In silico computer study and toxicology testing
Yoshihisa Inoue
IncromCRO
Alternatives to Animal Testing and Experimentation 22 (suppl) 24-24, 2017.
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S2-3 In silico prediction of the major clearance pathways of drugs and substrates of drug transporters based on the chemical structure of drugs
Kazuya Maeda
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 22 (suppl) 25-25, 2017.
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S2-4 R&D on toxicity prediction method using toxicity related big data and artificial intelligence Technology
Kazukuni Fukuhara
Ministry of Economy, Trade and Industry
Alternatives to Animal Testing and Experimentation 22 (suppl) 25-25, 2017.
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S3-1 AAALAC International Update : Present and Future
James R. Swearengen
AAALAC International
Alternatives to Animal Testing and Experimentation 22 (suppl) 26-26, 2017.
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S3-2 AAALAC International Accreditation Program in Korea : Present and Future
Byung-Choe1), Gwi Hyang Lee1),2), Yechan Jung3)
1)Nicholas Cardinal Cheong Graduate School for Life, The Catholic University of Korea, 2)Bioethics Information Center, 3)Research Ethics Center, Korea University
Alternatives to Animal Testing and Experimentation 22 (suppl) 26-26, 2017.
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S3-3 What I've learned through the experience of AAALAC's accreditation
Nobuya Sasaki, DVM, PhD, DJCLAM Professor
Laboratory of Laboratory Animal Science. Kitasato University
Alternatives to Animal Testing and Experimentation 22 (suppl) 27-27, 2017.
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S3-4 AAALAC International from the standpoint of a Japanese pharmaceutical company
Hidenori Watanabe
JAPAN TOBACCO INC, Central Pharmaceutical Research Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 27-27, 2017.
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S4-1 International situation of skin sensitization evaluation
Takao Ashikaga
National Institute of Health Sciences, Division of Risk Assessment
Alternatives to Animal Testing and Experimentation 22 (suppl) 28-28, 2017.
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S4-2 Three alternative test methods in the guidance of a system for evaluating skin sensitization for quasi-drug applications in Japan
Noriyasu Imai1),2)
1)Japan Cosmetic Industry Association, 2)KOSE Corporation
Alternatives to Animal Testing and Experimentation 22 (suppl) 28-28, 2017.
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S4-3 Guidance for skin sensitization evaluation-3 out of 3 for bottom-up-
Masaaki Miyazawa1),2)
1)Japan Cosmetic Industry Association, 2)Kao Corporation
Alternatives to Animal Testing and Experimentation 22 (suppl) 29-29, 2017.
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S4-4 The Association of Skin Safety Case Information Network (SSCI-Net) ; new system with website registration
Akiko Yagami1),2), Kayoko Suzuki1),2), Kayoko Matsunaga1),3)
1)The Association of SSCI-Net, 2)Department of Allergology, Fujita Health University Second Educational Hospital, 3)Department of Integrative Medical Science for Allergic Disease, Fujita Health University School of Medicine
Alternatives to Animal Testing and Experimentation 22 (suppl) 29-29, 2017.
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S5-1 Human micro-living system focusing on the tissue structures
Yoh ichi Tagawa
Tokyo Institute of Technology School of Life Science and Technology
Alternatives to Animal Testing and Experimentation 22 (suppl) 30-30, 2017.
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S5-2 Isolation and culture of the hepatic cells from residual resected liver tissue
Kumiko Tatsumi1),2), Jumpei Kondo2), Masahiro Inoue2), Yoshiharu Sakai1)
1)Department of Gastrointestinal Surgery, Graduate School of Medicine, Kyoto University, 2)Department of Biochemistry, Osaka International Cancer Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 30-30, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
S5-3 Application of normal cells based on islet transplant research
Hirofumi Noguchi
Graduate School of Medicine, University of the Ryukyu
Alternatives to Animal Testing and Experimentation 22 (suppl) 31-31, 2017.
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S5-4 Dissecting the diversity of carcinogenesis pathways of pancreatic cancer using human tumor cell resources including CTOS
Yusuke Mizukami
Department of Medicine, Asahikawa Medical University
Alternatives to Animal Testing and Experimentation 22 (suppl) 31-31, 2017.
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S5-5 Application of cancer tissue-originated spheroid (CTOS) method
Masahiro Inoue
Osaka International Cancer Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 32-32, 2017.
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S5-6 Construction of the medical BioBank for carrying out large scale analysis utilizing AI
Akihio Sekine1), Taiki Yamashita1), Ryo Takemura1), Yoichi Mashimo1), Masahiro Inoue2)
1)Center for Preventive Medical Science, Chiba University, 2)Department of Biochemistry, Osaka International Cancer Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 32-32, 2017.
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S5-7 Procurement of bio-resource for innovation of primary culture
Masahiro Inoue
Osaka International Cancer Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 33-33, 2017.
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S6-1 Global Development in emerging zebrafish-based "alternative" methods
Toshio Tanaka1),2)
1)Systems Pharmacology Mie University Graduate School of Medicine, 2)Mie University Medical Zebrafish Research Center
Alternatives to Animal Testing and Experimentation 22 (suppl) 33-33, 2017.
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S6-2 Efforts to optimize alternative methods for reproductive and developmental toxicity testing of drugs in Japan and improve the predictability of zebrafish embryo toxicity test through harmonization of international regulation
Michio Fujiwara
Drug Safety Research Labs, Astellas Pharma Inc.,
Alternatives to Animal Testing and Experimentation 22 (suppl) 34-34, 2017.
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S6-3 Application of genetically modified zebrafish for toxicity evaluation.
Akihito Yamashita
Sumitomo Dainippon Pharma Co., Ltd., Preclinical Research Laboratories
Alternatives to Animal Testing and Experimentation 22 (suppl) 34-34, 2017.
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S6-4 Development of a genome-design medaka for an industrial application
Tomonori Deguchi
National Institute of Advanced Industrial Science and Technology (AIST), Biomedical Research Institute, Advanced Genome Design Research Group
Alternatives to Animal Testing and Experimentation 22 (suppl) 35-35, 2017.
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S6-5 Establishment of brain ischemia-reperfusion model using zebrafish and evaluation of drug efficacy
Toshiaki Kume
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
Alternatives to Animal Testing and Experimentation 22 (suppl) 35-35, 2017.
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S7-1 Progress and challenges of genome editing technology
Masahito Ikawa
Research Institute for Microbial Diseases, Osaka University
Alternatives to Animal Testing and Experimentation 22 (suppl) 36-36, 2017.
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S7-2 ES/iPS cell-derived mammalian living models by using micro-fluidic devices
Yoh ichi Tagawa
Tokyo Institute of Technology School of Life Science and Technology
Alternatives to Animal Testing and Experimentation 22 (suppl) 36-36, 2017.
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S7-3 Utilization of human iPSC-derived cardiomyocytes and human iPSC-derived neurons for drug discovery - Trial for microelectrode array data analysis using deep learning
Norimasa Miyamoto
Eisai Co., Ltd., Tsukuba Research Laboratories
Alternatives to Animal Testing and Experimentation 22 (suppl) 37-37, 2017.
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S7-4 A humanized mouse model that is useful for basic medical research and new drug development
Hiroshi Suemizu
Central Institute for Experimental Animals
Alternatives to Animal Testing and Experimentation 22 (suppl) 37-37, 2017.
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S7-5 Use of animal models for human disease in nonclinical safety assessment of new drugs
Masayuki Tomohiro1),2)
1)Non-clinical Evaluation Expert Committee, Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association, 2)Novartis Pharma K. K.
Alternatives to Animal Testing and Experimentation 22 (suppl) 38-38, 2017.
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S8-1 Current status of GCCP in testing method
Yasunari Kanda
Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 38-38, 2017.
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S8-2 Quality variability and good cell culture practice for human stem cells
Kusuda Miho Furue1),2)
1)Laboratory of Stem Cell Cultures, National Institutes of Biomedical Innovation, Health and Nutrition, 2)Stem Cell Business Development Section, Healthcare Business Unit, NIKON Corporation
Alternatives to Animal Testing and Experimentation 22 (suppl) 39-39, 2017.
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S8-3 Good Cell Culture Practice in terms of Regenerative Medicine
Sachiko Ezoe
Osaka University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 22 (suppl) 39-39, 2017.
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S8-4 Body on a Chip : Micro / Nanoengineered in vitro human model and its applications for Good Cell Culture Practice
Kenichiro Kamei
Institute for Integrated Cell-Material (WPI-iCeMS), Kyoto University
Alternatives to Animal Testing and Experimentation 22 (suppl) 40-40, 2017.
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W1-1 In vitro repeated exposure study using a three-dimensional cell culture model of human bronchial tissue for assessment of aerosol chemicals
Shinkichi Ishikawa, Kazushi Matsumura, Nobumasa Kitamura, Yuichiro Takanami, Shigeaki Ito
Scientific Product Assessment Center, Japan Tobacco Inc.
Alternatives to Animal Testing and Experimentation 22 (suppl) 40-40, 2017.
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W1-2 Construction of 3D skin model using layer-by-layer cell manipulation and the future prospects as alternatives to animal testing
Mitsuru Akashi
Graduate School of Frontier Biosciences, Osaka University
Alternatives to Animal Testing and Experimentation 22 (suppl) 41-41, 2017.
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W1-3 Approach for detecting weak skin irritation due to cosmetic ingredients without using animal testing
Mariko Sugiyama
Shiseido Global Innovation Center
Alternatives to Animal Testing and Experimentation 22 (suppl) 41-41, 2017.
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W1-4 Applying the Depth of Injury Concept to Bovine Corneal Histopathology to Support Corneal Recovery Predictions
Hans Raabe
Institute for In Vitro Sciences, Inc.
Alternatives to Animal Testing and Experimentation 22 (suppl) 42-42, 2017.
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W1-5 Approach for assessing the mild irritants in the Bovine Corneal Opacity and Permeability Test (BCOP Test)
Masatoshi Furukawa
Safety Research Institute for Chemical Compounds Co., Ltd.,
Alternatives to Animal Testing and Experimentation 22 (suppl) 42-42, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
W1-6 Evaluation of corneal damage recovery using three-dimensional corneal re-construction model
Naoki Yamamoto
Division of Molecular Biology, Joint Research Support Promotion Facility, Center for Research Promotion and Support, Fujita Health University
Alternatives to Animal Testing and Experimentation 22 (suppl) 43-43, 2017.
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W2-1 Importance and role of an alternative method for safety assessment in cosmetic development
Hidefumi Ikeda
Product Assurance Division, Mandom corp.,
Alternatives to Animal Testing and Experimentation 22 (suppl) 43-43, 2017.
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W2-2 Importance and role of alternative to animal experiments in safety evaluation of chemical development
Toshihiko Kasahara
Fujifilm Corporation, Safety Evaluation Center, Ecology&Quality Management Div. Csr. Div
Alternatives to Animal Testing and Experimentation 22 (suppl) 44-44, 2017.
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W2-3 Expectation of the alternative methods for safety and security of food
Asuka Takumi
Institute for Innovation, Ajinomoto Co., Inc.
Alternatives to Animal Testing and Experimentation 22 (suppl) 44-44, 2017.
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W2-4 Current usage and future perspective of the alternative test methods in NISSIN FOODS Group.
Taisei Mizota
NISSIN FOODS HOLDINGS CO., LTD. Global Food Safety Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 45-45, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
W2-5 The expected role of alternative methods in non-clinical drug safety assessment
Jumpei Kiyokawa, Tomoaki Inoue
Safety Assessment Department, Research Division, Chugai Pharmaceutical Co., Ltd.
Alternatives to Animal Testing and Experimentation 22 (suppl) 45-45, 2017.
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W2-6 The current state and issues of utilizing alternatives to animal experiments for safety evaluation of drugs in our company
Motoki Umeda
Drug Development Research Laboratories, Maruho Co., Ltd.
Alternatives to Animal Testing and Experimentation 22 (suppl) 46-46, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
PD-1 Feeling ahead of "poor" to experimental animals
Kyoko Ota
Japan Children's Literary Association
Alternatives to Animal Testing and Experimentation 22 (suppl) 46-46, 2017.
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PD-2 Significant advance of alternatives, legal reform expected for more progress
Eiko Mori
JIJI PRESS
Alternatives to Animal Testing and Experimentation 22 (suppl) 47-47, 2017.
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PD-3 Outline of regulations on cosmetics and quasi-drugs in Japan
Taku Oohara
Ministry of Health, Labour and Welfare
Alternatives to Animal Testing and Experimentation 22 (suppl) 47-47, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
PD-4 R&D on toxicity prediction method in METI using toxicity related big data and artificial intelligence Technology
Kazukuni Fukuhara
Ministry of Economy, Trade and Industry
Alternatives to Animal Testing and Experimentation 22 (suppl) 48-48, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
PD-5 Alternatives to Animal Testing and Japan's Role in Animal Welfare
Sachiko Azuma
PEACE
Alternatives to Animal Testing and Experimentation 22 (suppl) 48-48, 2017.
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PD-6 Sciences toward Animal-Free Understanding of Human Body Responses
Yasuyuki Sakai1),2)
1)Department of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, 2)International Research Center on Integrative Biomedical Systems, Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 22 (suppl) 49-49, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
M-1 Development of an in vitro evaluation system for drugs with liver injury potentially associated with mitochondrial toxicity
Kousei Ito
Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 22 (suppl) 49-49, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
M-2 Protective effects and safety of molecular hydrogen on H9c2 cardiomyocytes model
Yuji Yoshiyama
Research and education center for clinical pharmacy, School of pharmacy, Kitasato University
Alternatives to Animal Testing and Experimentation 22 (suppl) 50-50, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
LS1-1 Introduction of alternative animal testing method for prediction of eye irritation
Masakazu Katoh
Japan Tissue Engineering Co. , Ltd.
Alternatives to Animal Testing and Experimentation 22 (suppl) 50-50, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
LS1-2 In vitro screening of compounds with severe drug-induced liver injury risk focusing on differentiation and maturation process of hepatocytes
Kousei Ito
Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 22 (suppl) 51-51, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
LS2-1 Recent Developments of Toxicological Alternative Methods in China
Shuangqing Peng1), XingFen Yang2),3), JiaBin Guo1), Ying Yang3), Jin Li4), Qing Li3)
1)The institute of Disease control and prevention, Academy of Military Medical, Sciences, 2)School of Public Health, Southern Medical University, 3)Guangdong Province Centre for Disease Control and Prevention, 4)Unilever
Alternatives to Animal Testing and Experimentation 22 (suppl) 51-51, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
LS2-2 Current Activities for the Development and Validation of Alternative Test Methods in Korea
Tae Cheon Jeong1), Mi-Jeong Kang1), Mahesh R. Nepal1), Kyungyuk Ko2), Tae Sung Kim2), Jong Kwon Lee2)
1)College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea, 2)National Institute of Food and Drug Safety Evaluation, KFDA, Republic of Korea
Alternatives to Animal Testing and Experimentation 22 (suppl) 52-52, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
LS3-1 An in vitro co-culture system to assess lipophilic chemicals and petroleum chemicals for skin sensitization
Shunjun Chwng1), Yu Chen2), Hua Shen3), Yihui Ke2)
1)Guangdong Inspection&Quarantine Technology Center, Guangzhou, 2)Guangzhou Chn-alt Biotechnology Co. Ltd., Guangzhou, 3)Shell International Petroleum Co. Ltd.,
Alternatives to Animal Testing and Experimentation 22 (suppl) 52-52, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
LS3-2 An integrated testing strategy for in vitro skin irritation and corrosive assessment using EpiSkin TM skin model
Junming Huang1), Ying Yang1), Xingfen Yang1), Zhenzi Cai2), E Xhao2), Nan Li2), Qing Li1), Yanfeng Liu1), Meifen Chen1), Xikun Xiong1), Yangshen Liang1), Caichun Ke1), Xin Chen1)
1)Guangdong Province Center for Disease Control and Prevention, Guangzhou, China, 2)L'Oreal China Research and Imovation Center, Shanghai
Alternatives to Animal Testing and Experimentation 22 (suppl) 53-53, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
JSAAE AWARD The development of the IL-8 Luc assay (OECD TG 442E)
Setsuya Ariba
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 22 (suppl) 53-53, 2017.
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SS-1 The biggest prize in the world "Lush Prize" and newest world trend of the animal testing alternatives.
Rebecca Ram
Scientific Research Consultant, Lush Prize UK
Alternatives to Animal Testing and Experimentation 22 (suppl) 54-54, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
SS-2 The challenge to establish individual liver assay models and social system for human specimen utilization
Kumiko Tatsumi1),2)
1)Department of Gastrointestinal Surgery, Graduate School of Medicine, Kyoto University, 2)Department of Biochemistry, Osaka International Cancer Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 54-54, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-1 Comparison of magnetic nanoparticles genotoxicities in in vivo and in vitro models : evaluating the utility of substrata made from tissue / organ sections for histopathology - based systems
Shungo Saito1),2), Tadashi Nittami1), Hiroshi Itagaki1), Yukari Totsuka2), Yohei Miyagi3), Masatoshi Watanabe1),4)
1)Graduate School of Engineering, Yokohama National University, 2)Division of Carcinogenesis and Prevention, National Cancer Center Japan, 3)Molecular Pathology&Genetics Division, Kanagawa Cancer Center Research Institute, 4)Faculty of medicine, Mie University
Alternatives to Animal Testing and Experimentation 22 (suppl) 55-55, 2017.
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P-2 Usefulness of three-dimensional cultured skin (LSE-high) in in vitro skin permeation study of quasi-drugs
Takashi Maeda1), Kazutaka Nojimoto1), Katsuhiro Nakayama1), Takanori Kuramochi1), Hiroyuki Takeuchi1), Motoki Hiramori1), Arata Watanabe2), Hiroaki Todo2), Kenji Sugibayashi2)
1)R&D Department, Yokohama Laboratory Roman Industries Co. , Ltd., 2)Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 22 (suppl) 55-55, 2017.
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P-3 The methods to control spheroids formation speed on novel polymer and application for 3D cell culture scaffold material.
Naoto Ogiwara, Keisuke Kurauchi, Yuta Furumi
TOYO INK SC HOLDINGS CO., LTD.
Alternatives to Animal Testing and Experimentation 22 (suppl) 56-56, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-4 Pain responses of cultured human iPSC-derived sensory neurons using MEA system
Aoi Odawara1),2),3), Naoki Matsuda2), Ikuro Suzuki2)
1)Tohoku University, 2)Tohoku Institute of Technology, 3)JSPS
Alternatives to Animal Testing and Experimentation 22 (suppl) 56-56, 2017.
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P-5 Study for environmental stress response of 3D reconstructed corneal models SkinEthic TM HCE (Human Corneal Epithelium)
Yuki Yamashita1), Hitoshi Masaki2)
1)NIKKOL GROUP Nikoderm Research Inc., 2)Tokyo University of Technology, School of Bionics
Alternatives to Animal Testing and Experimentation 22 (suppl) 57-57, 2017.
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P-6 The protocol on "a test method for hepatic metabolism and excretion of chemicals" useful for the technical transfer
Ayumi Oshikata, Toshiaki Takezawa
Division of Biotechnology, Institute of Agrobiological Sciences, National Agriculture and Food Research organization
Alternatives to Animal Testing and Experimentation 22 (suppl) 57-57, 2017.
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P-7 Development of novel in vivo estrogen-like effects screening assay using estrogen reporter "E-Rep" mice.
Motoshi Furukawa, Kazuaki Horibe, Shinya Shimizu, Tsuyoshi Nakanishi, Hisamitsu Nagase
Gifu Pharmaceutical University
Alternatives to Animal Testing and Experimentation 22 (suppl) 58-58, 2017.
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P-8 Utility of 4CYPs-introduced HepG2 cells in mitochondrial toxicity evaluation in consideration of metabolites
Shibin Kyu1), Moemi Kawaguchi1), Shuichi Sekine1), Akinori Takemura1), Daisuke Satoh2), Yasuhiro Kazuki2), Mistuo Oshimura2), Toru Horie3), Kousei Ito1)
1)Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 2)Chromosome Engineering Research Center Tottori University, 3)Drug Discovery and Development Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 58-58, 2017.
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P-9 Development of a Novel Placental Drug Transport Assay Using Placental Cells Derived from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells.
Kouji Asano1), Noriyuki Suzuki1), Yasuhiko Takahashi1), Yoshitaka Tomigahara1), Koichi Saito2)
1)Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 2)Advanced Materials Development Laboratory, Sumitomo Chemical Co., Ltd.
Alternatives to Animal Testing and Experimentation 22 (suppl) 59-59, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-10 Establishment of stable effector cell line and application to antibody-dependent cellular cytotoxicity assay for anti-TNFα antibody
Haruka Hirosaki1), Yosuke Maeda1),2), Hidenori Yamanaka1), Masahiro Takeyoshi1), Hiroyuki Iwata2)
1)Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, 2)The United Graduate School of Veterinary Science, Yamaguchi University
Alternatives to Animal Testing and Experimentation 22 (suppl) 59-59, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-11 Multi-Immuno Tox Assay (MITA) : the creation of its data set and the results of validation studies
Yutaka Kimura1), Rie Yasuno2), Mika Watanabe3), Miwako Kobayashi3), Tomoko Iwaki4), Chizu Fujimura1), Yoshihiro Ohmiya2), Kohji Yamakage3), Yoshihiro Nakajima4), Mayumi Kobayashi5), Takashi Omori5), Hajime Kojima6), Setsuya Aiba1)
1)Department of Dermatology, Tohoku University Graduate School of Medicine, 2)Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 3)Hatano Research Institute, Food and Drug Safety Center, 4)Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 5)Division of Biostatistics, Department of Social / Community Medicine and Health Science, Kobe University School of Medicine, 6)Japanese Center for the Validation of Alternative Methods, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 60-60, 2017.
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P-12 Transient ischemia with activating mitochondrial function induces cell death by opening mitochondrial transition pore
Yugo Ikeyama, Tomoyuki Sato, Shuichi Sekine, Koichi Arakawa, Kousei Ito
Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba Univercity
Alternatives to Animal Testing and Experimentation 22 (suppl) 60-60, 2017.
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P-13 Verification of the correlation between animal testing and in vitro evaluation system using 3D culture scaffold Cellbed on drug resistance overcoming phenomenon
Taku Matsushita1), Kousuke Inamura1), Kazumi Emoto1), Takahiro Mizutami1), Yuji Komizu1), Hideaki Ichihara1), Takuya Iwasa2), Kouhei Sasaki2), Rie Watanabe2), Masaaki Kawabe2), Yoko Matsumoto1)
1)Dept. of Applied Life Science, Sojo University, 2)Central Research Laboratory, Japan Vilene Company, Ltd
Alternatives to Animal Testing and Experimentation 22 (suppl) 61-61, 2017.
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P-14 Development of next generation 3D skin model ; "Advanced Skin TM", for the evaluation of both functional materials and cosmetic products.
Katsunari Tezuka1),2), Miho Ogawa1),2), Ayako Tsuchiya2), Shun Kimura2), Kohei Toyoshima1),2), Naokazu Okamoto1),2), Takashi Tsuji1),2)
1)Organ Technologies Inc., 2)RIKEN Center for Developmental Biology
Alternatives to Animal Testing and Experimentation 22 (suppl) 61-61, 2017.
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P-15 Multi-laboratory validation study of ADRA as novel in chemico alternative test method for skin sensitization : 2nd report
Ono Atsushi1), Shinichi Watanabe2), Tsunetsugu Sugawara2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Kusakari Kei5), Yoshihiko Kurokawa5), Takashi Sozu6), Takuto Nakayama6), Takeru Kusao6), Tsuyoshi Kawakami7), Kohichi Kojima8), Hajime Kojima9), Jon Richmond10), Nicole Kleinstreuer11), Kim BaeHwa12), Yusuke Yamamoto13), Masaharu Fujita13), Kasahara Toshihiko13)
1)Okayama University, Graduate school of Medicine, Dentistry and Pharmaceutical sciences, 2)LION CORPORATION, HUMAN & ENVIRONMENTAL SAFETY EVALUATION CENTER, 3)MITSUI CHEMICALS, Ins. , Chemicals Safety Department, 4)SUMITOMO Chemical Co. , Ltd. , Environmental Health Science Laboratory, 5)NISSAN CHEMICAL INDUSTRIES, LTD. Biological Research Laboratories, 6)Tokyo University of Science, Department of Information and Computer Technology, Faculty of Engineering, 7)National Institute of Health Sciences, Division of Environmental Chemistry, 8)Food and Drug Safety Center, Hatano Research Institute, 9)National Institute of Health Sciences, Biological safety Research Center, Division of Risk Assessment, 10)Dr. JonRichmond : Advice and Consultancy, 11)NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), 12)College of Natural Sciences Keimyung University, 13)FUJIFILM Corporation, Safety Evaluation Center
Alternatives to Animal Testing and Experimentation 22 (suppl) 62-62, 2017.
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P-16 Novel skil sensitization test systems using Peptide - immobilized polystyrene - microbeads
Kenji Usui1), Hiroshi Miyazaki2), Yuuki Minamino3), Hideaki Mekata3), Masayuki Takaishi3), Hidefumi Ikeda3), Kunihiko Yamashita2), Yoshio Hamada1)
1)Konan University, 2)Daicel Corp., 3)Mandom Corp.
Alternatives to Animal Testing and Experimentation 22 (suppl) 63-63, 2017.
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P-17 Evaluation of indirect activation of CAR in 3D-cultured HepG2 cells
Kaoru Kobayashi, Ikuko Azuma, Kosuke Yokobori, Kan Chiba, Hidetaka Akita
Chiba University, Graduate School of Pharmaceutical Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 63-63, 2017.
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P-18 Inkjet bioprinting applied to the development of in vitro cell-based assays
Waka Lin1), Natsuko Hemmi1), Shusaku Shiomoto1), Tomoaki Nakayama1), Yosuke Tabei2), Masanori Horie2), Takanori Tano1), Daisuke Takagi1)
1)RICOH COMPANY, LTD. , Biomedical Research Department, 2)National Institute of Advanced Industrial Science and Technology, Health Research Institute
Alternatives to Animal Testing and Experimentation 22 (suppl) 64-64, 2017.
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P-19 Establishment of a HepG2-NIAS cell line and its characteristics
Toshiaki Takezawa, Ayumi Oshikata
Institute of Agrobiological Sciences, National Agriculture and Food Research Organization
Alternatives to Animal Testing and Experimentation 22 (suppl) 64-64, 2017.
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P-20 Basic study on the development of in vitro developmental toxicity tests using human iPS cell-derived cranial neural crest-like cells
Mika Suga1),2), Sumiyo Mimura3), Yujung Liu2), Takako Nakano2), Hiroki Nikawa3), Miho K Furue2)
1)Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 2)Laboratory of Stem Cell Cultures, National Institutes of Biomedical Innovation, Health and Nutriton, 3)Department of Oral Biology and Engineering, Graduate School of Biomedical and Health Sciences, Hiroshima University
Alternatives to Animal Testing and Experimentation 22 (suppl) 65-65, 2017.
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P-21 Traumatic brain injury and aging in Drosophila melanogaster
Rikako Sanuki1),2)
1)Kyoto Institute of Technology, Institute for the Promotion of University Strategy Global Excellence, 2)Kyoto Institute of Technology, Drosophila Genomics and Genetic Resources
Alternatives to Animal Testing and Experimentation 22 (suppl) 65-65, 2017.
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P-22 Lead inhibits microglial cell migration via suppression of store-operated calcium entry
Fei Zou, Jiawen Peng, Wei Tang, Yuhao Wang, Fan Zhou, Xiaojing Meng
Department of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University
Alternatives to Animal Testing and Experimentation 22 (suppl) 66-66, 2017.
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P-23 Enhanced Hepatocyte function by coculture with Fibroblast using 3D Silica Nonwoven Fabrics
Shohei Ishikawa1), Yuki Takahashi2), Kohei Sasaki3), Masaaki Kawabe3), Hidenori Otsuka1),2)
1)Graduate School of Science, Tokyo University of Science, 2)Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 3)Central Research Laboratory, Japan Vilene Company Ltd.
Alternatives to Animal Testing and Experimentation 22 (suppl) 66-66, 2017.
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P-24 Characteristics of co-cultured hepatocytes in monolayer and spheroid cultures
Yusuke Ota, Hideo Yokoyama, Daisuke Miyamoto, Kohji Nakazawa
Department of Life and Environment Engineering, The University of Kitakyushu
Alternatives to Animal Testing and Experimentation 22 (suppl) 67-67, 2017.
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P-25 Monocyte culture using microwell chip
Tatsuya Kitajima, Daisuke Miyamoto, Kohji Nakazawa
Department of Life and Environment Engineering, The University of Kitakyushtt, Fukuoka, Japan
Alternatives to Animal Testing and Experimentation 22 (suppl) 67-67, 2017.
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P-26 Drug responsiveness of HepG2 spheroids using microwell chip culture
Daisuke Go, Yui Ishizaki, Daisuke Miyamoto, Khoji Nakazawa
The University of Kitakyushu
Alternatives to Animal Testing and Experimentation 22 (suppl) 68-68, 2017.
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P-27 Development of drug screening device using seesaw type bioreactor
Keito Iseki, Junji Fukuda
Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 68-68, 2017.
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P-28 Aerobic culture of multicellular spheroids by static oxygen supply method
Hirotaka Mihara1), Yasuyuki Sakai2), Nobuhiko Kojima1)
1)Graduate School of Engineering, Yokohama City University, 2)Graduate School of Engineering, University of Tokyo
Alternatives to Animal Testing and Experimentation 22 (suppl) 69-69, 2017.
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P-29 Catch-and-release of target cells using electrochemical cell detachment
Junko Enomoto, Junji Fukuda
Faculty of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 69-69, 2017.
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P-30 Spheroids of various cell types on oxygen-permeable Plate
Kisaki Onishi, Junji Fukuda
Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 70-70, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-31 Fabrication of In vitro blood vessel model with smooth muscle cell layer
Yuka Shimazu, Dina Myasnikova, Junji Fukuda
Faculty of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 70-70, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-32 Fabrication of tailor-made cell sheets using micro stereolithography and electrochemical cell transfer
Yuka Kobayashi1), Christopher Cordonier2), Yohei Noda1), Hideo Honma2), Shoji Maruo1), Junji Fukuda1)
1)Yokohama National University, 2)Kanto Gakuin University
Alternatives to Animal Testing and Experimentation 22 (suppl) 71-71, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-33 Evaluation of the effect of oxygen on human hepatocytes culture by using oxygen permeable membrane
Keiichi Kimura1), Marie Shinohara2), Wenjin Xiao2), Yasuyuki Sakai1),2)
1)Graduate School of Engineering, University of Tokyo, 2)Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 22 (suppl) 71-71, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-34 Studies of cytotoxicity assays by using Plant cultured cells
Riko Ito1), Hiroshi Itagaki2), Kazuyuki Hiratsuka1), Shinichi Ogata1)
1)Graduate School of Environment and Information Sciences, Yokohama National University, 2)Graduate School of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 72-72, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-35 Analysis of the combined effect of magnetic nanoparticles and docetaxel on prostate cancer cells
Kanako Kojima1), Tadashi Nittami1), Hiroshi Itagaki1), Masatoshi Watanabe2)
1)Graduate School of Engineering, Yokohama National University, 2)Graduate School of Medicine, Mie University
Alternatives to Animal Testing and Experimentation 22 (suppl) 72-72, 2017.
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P-36 Preparation method of cardiomyocytes tissue models by Microscopic Coating Applicator of needle method
Haruka Nakamura1),2)
1)NTN corporation New product development R&D center, 2)Graduate School of Frontier Biosciences, Osaka University
Alternatives to Animal Testing and Experimentation 22 (suppl) 73-73, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-37 Analysis of AtRad51 in response to DNA damage
Shinya Nanaumi, Norihito Kowada, KazuyUki Hiratsuka, Shinichi Ogata
Graduate School of Environment and Information Sciences, Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 73-73, 2017.
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P-38 Toward the Development of an in Vitro Allergy Test Device Integrated with an Electrochemical Histamine Biosensor
Kikuo Komori, Masaharu Nakane, Yasuyuki Sakai
University of Tokyo
Alternatives to Animal Testing and Experimentation 22 (suppl) 74-74, 2017.
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P-39 Hybrid liposomes inhibit the growth of liver cancer stem cells
Yuji Komizu1), Kousuke Inamura1), Seiichi Ishida2), Matsumoto Yoko1), Matsushita Taku1)
1)Sojo University, Dept. of Applied Life Science, 2)National Institute of Health Sciences, Division of Pharmacology
Alternatives to Animal Testing and Experimentation 22 (suppl) 74-74, 2017.
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P-40 Alternative to Animal Experiment for polypharmacy using chick embryos
Yuji Yoshiyama, Hideto Ariumi, Hiroyuki Miyazaki
Kitasato University School of Pharmacy
Alternatives to Animal Testing and Experimentation 22 (suppl) 75-75, 2017.
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P-41 Multi-throughput multiorgan-on-a-chip platform using a pneumatic pressure-driven medium circulation system
Shinji Sugiura1), Taku Satoh1), Kazumi Shin1), Reiko Nagasaki1), Seiichi Ishida2), Kiyomi Kikuchi3), Motoharu Kakiki3), Toshiyuki Kanamori1)
1)National Institute of Advanced Industrial Science and Technology (AIST), 2)National Institute of Health Sciences, 3)Eisai Co. Ltd.
Alternatives to Animal Testing and Experimentation 22 (suppl) 75-75, 2017.
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P-42 Mass-production System of Spheroids by Combining Cluster Culture Device "TASCL" and Label-free Image Analysis
Masashi Ikeuchi1),3), Chihiro Aoyama1), Shuji Hayashi2),3)
1)Graduate School of Information Science and Technology, The University of Tokyo, 2)The Foundation for Global Health Care, 3)CYMSS Inc.
Alternatives to Animal Testing and Experimentation 22 (suppl) 76-76, 2017.
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P-43 Analysis of Osteogenic Differentiation Behaviors of Bone Marrow-Derived Mesenchymal Stem Cells Cultured in Silica Nonwoven Fabrics
Kazutoshi Iiiima1), Shohei Ishikawa2), Mineo Hashizume1), Hidenori Otsuka2)
1)Faculty of Engineering, Tokyo University of Science, 2)Graduate School of Science, Tokyo University of Science
Alternatives to Animal Testing and Experimentation 22 (suppl) 76-76, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-44 1,2-Dichloroethane induces reproductive toxicity mediated by the CREM / CREB signaling pathway in male NIH Swiss mice
Zhelie Huang1), Yating Zhang2), Xingfen Yang3)
1)Department of Toxicology, Guangdong Provincial Hospital for Occupational Disease Prevention and Treatment, 2)School of Public Health, Guangdong Pharmaceutical University, 3)School of Public Health, Southern Medical University
Alternatives to Animal Testing and Experimentation 22 (suppl) 77-77, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-45 Development of in silico model for predicting idiosyncratic drug-induced hepatotoxicity risk
Kosuke Imai, Atsushi Ono
Faculty of Pharmaceutical, Okayama University
Alternatives to Animal Testing and Experimentation 22 (suppl) 77-77, 2017.
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P-46 Evaluation of the performance measures used in the validation for the h-CLAT and DPRA methods
Takuto Nakayama1), Takashi Sozu2)
1)Department of Management Science, Tokyo University of Science Graduate School of Engineering, 2)Department of Information and Computer Technology, Facuhy of Engineering, Tokyo University of Science
Alternatives to Animal Testing and Experimentation 22 (suppl) 78-78, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-47 Development of in vitro hepatotoxicity assessment system to predict the toxicological potential of cosmetic raw materials
Takumi Nukaga1),2), Moemi Kawaguchi2), Shuichi Sekine2), Akinori Takemura2), Takeshi Susukida2), Morihiko Hirota1), Shiho Oeda1), Tomohiko Miyagawa1), Akiko Tamura1), Atsushi Kodama1), Kousei Ito2), Hirokazu Kouzuki1)
1)Global Innovation Center, Shiseido, 2)Graduate school of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 22 (suppl) 78-78, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-48 Comparison of basal and induced activities of various types of Cytochrome P450 enzymes in PXB-able TM and 3D cultured primary human hepatocyte on Cell-able plate
Tomoko Jomura1), Yuki Akahira1), Chihiro Yamasaki2), Yuji Ishida2),3), Chise Tateno2),3)
1)TOYO GOSEI CO., LTD. Photosensitive Materials Research Center Biotech Applications Group, 2)PhoenixBio Co., Ltd., 3)Liver Research Project Center in Hiroshima
Alternatives to Animal Testing and Experimentation 22 (suppl) 79-79, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-49 Evaluation of uptake / efflux transporter expression and function in ECM loaded spheroid
Fumiya Tao, Yuki Asakura, Nobuhiko Kojima
Yokohama City University
Alternatives to Animal Testing and Experimentation 22 (suppl) 79-79, 2017.
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P-50 Comparative metabolome analysis and toxicity test of cultured fetal and adult hepatocytes in humans (4th Report)
Asuka Shiraki1), Kousuke Inamura1), Takahiro Mizutami1), Yuji Komizu1), Su Ryang Kim2), Seiichi Ishida2), Taku Matsushita1)
1)Department of Applied Life Science, Sojo University, 2)Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 80-80, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-51 In vitro reproduction of drug resistance phenomena and biliary excretion of HepG2 cells using 3D culture scaffold, Cellbed
Maya Nakamura1), Takahiro Mizutami1), Yuji Komizu1), Takuya Iwasa2), Kouhei Sasaki2), Rie Watanabe2), Masaaki Kawabe2), Seiichi Ishida3), Taku Matsushita1)
1)Dept. of Applied Life Science, Sojo University, 2)Central Research Laboratory, Japan Vilene Company, Ltd., 3)Division of Pharmacology, National Institute of Health Sciences.
Alternatives to Animal Testing and Experimentation 22 (suppl) 80-80, 2017.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-52 Evaluation in functional expression and maintenance culture of cryopreserved human hepatocyte using Cellbed as 3D scaffold
Hanaka Nagasaki1), Takahiro Mizutami1), Yuji Komizu1), Takuya Iwasa2), Kouhei Sasaki2), Rie Watanabe2), Masaaki Kawabe2), Seiichi Ishida3), Taku Matsushita1)
1)Dept. of Applied Life Science, Sojo University, 2)Central Research Laboratory, Japan Vilene Company, Ltd, 3)Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 81-81, 2017.
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P-53 The three-dimensional reconstructed corneal model using an immortalized human corneal epithelial cell line (iHCE-NY) on alternative eye irritation test method.
Noriko Hiramatsu1), Naoki Yamamoto2), Yoshinao Kato3), Atsushi Sato3), Sumito Isogai4), Kazuyoshi Imaizumi4), Atsuhiro Tanikawa5), Koji Hirano5), Masayuki Horiguchi5), Hajime Kojima6)
1)The Graduate School of Medicine, Fujita Health University, 2)Division of Molecularbiology, Joint Research Support Promotion Facility, Fujita Health University, 3)Nippon Menard Cosmetic Co., Ltd., 4)Department of Respiratory Medicine, School of Medicine, Fujita Health University, 5)Department of Ophthalmology, School of Medicine, Fujita Health University, 6)National Institute of Health Sciences (NIHS)
Alternatives to Animal Testing and Experimentation 22 (suppl) 81-81, 2017.
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P-54 Addressing the exceptions of the applicability domain for highly volatile substances in the Short Time Exposure (STE) test method for assessing eye irritation potential
Takayuki Abo1),2), Takuo Yuki1), Daisuke Araki1), Yutaka Takahashi1), Hitoshi Sakaguchi1), Hiroshi Itagaki2)
1)Kao Corporation, R&D - Safety Science Research, 2)Yokohama National University, Graduate School of Engineering
Alternatives to Animal Testing and Experimentation 22 (suppl) 82-82, 2017.
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P-55 Photosafety assessment of dermally applied chemicals by combined use of photochemical and pharmacokinetic data
Yoshiki Seto, Hiroto Ohtake, Hideyuki Sato, Satomi Onoue
Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 22 (suppl) 82-82, 2017.
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P-56 Study of in vitro phototoxic test using a 3D human epidermal skin model (LabCyte)
Mami Kawai1), Satoko Aoki2), Hiroko Okutomi2), Mika Watanabe2), Kohji Yamakage2), Amane Inoue1)
1)Rohto Pharmaceutical Co., Ltd., 2)Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 22 (suppl) 83-83, 2017.
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P-57 Construction of 3D skin model using layer-by-layer cell coating technology and their utilization as skin Irritation tests
Takami Akagi, Mitsuru Akashi
Graduate School of Frontier Biosciences, Osaka University
Alternatives to Animal Testing and Experimentation 22 (suppl) 83-83, 2017.
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P-58 Study of in vitro irritation testing in feminine hygene products using a reconstructed human vaginal mucosa epithelium model (part 2)
Shoko Koizumi, Hidefumi Ikeda, Masayuki Takaishi
Product Assurance Division, Mandom Corp.
Alternatives to Animal Testing and Experimentation 22 (suppl) 84-84, 2017.
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P-59 Evaluation of Mild Irritant Based on the Pathological Findings on the Cornea in the Bovine Corneal Opacity and Permeability Test (BCOP Test, an Alternative Method of Eye Irritation Test)
Masatoshi Furukawa1), Takashi Sakakibara1), Kouta Itoh1), Masao Matsuura1), Hajime Kojima2)
1)Safety Research Institute for Chemical Compounds Co., Ltd., 2)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 84-84, 2017.
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P-60 Use of in silico methods in skin corrosion and irritation IATA
Atsutoshi Abe, Takuhito Sezaki, Katsutoshi Kinoshita
Mitsui Chemicals, Inc., Responsible Care&Quality Assurance Division, Chemicals Safety Department
Alternatives to Animal Testing and Experimentation 22 (suppl) 85-85, 2017.
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P-61 Contributions of CYP1A1, 1A2 or 2B6 to the focus formation in Bhas42 cell transformation assay with 3-methylcholanthrene
Takashi Hirooka1), Keiko Abe1),2), Kiyomi Ohmori3)
1)KISTEC, 2)Graduate School of Agricultural and life Science, Tokyo University, 3)Kanagawa Prefectural Institute of Public Health
Alternatives to Animal Testing and Experimentation 22 (suppl) 85-85, 2017.
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P-62 Non-genotoxic carcinogen-induced changes in gene expression on Bhas 42 cell transformation assay
Kiyomi OHmori1), Asuka Kamei2), Yuki Watanabe2), Keiko Abe2),3)
1)Kanagawa Prefectural Institute of Public Health, 2)Kanagawa Institute of Industrial Science and Technology, 3)The University of Tokyo
Alternatives to Animal Testing and Experimentation 22 (suppl) 86-86, 2017.
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P-63 Statistical formulation for between-laboratory reproducibility in validation of alternative test methods
Takashi Sozu1), Takuto Nakayama2), Hitomi Sato3)
1)Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, 2)Department of Management Science, Tokyo University of Science Graduate School of Engineering, 3)Department of Management Science, Faculty of Engineering, Tokyo University of Science
Alternatives to Animal Testing and Experimentation 22 (suppl) 86-86, 2017.
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P-64 Comparison of animal experimentation protocols between US and Japan : How Japanese protocols can be improved
Akishige Fujisawa
Specified Nonprofit Corporation All Life In a Viable Environment
Alternatives to Animal Testing and Experimentation 22 (suppl) 87-87, 2017.
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P-65 Me-too Validation Study of Reconstructed Human Epidermal Model, LabCyte EPI-MODEL24 Skin Corrosivity Test Method
Hajime Kojima1), Azusa Mori2), Mayumi Kobayashi2), Nana Mashita3), Nobuyuki Shinoda4), Saori Hagiwara4), Yusuke Yamamoto5), Toshihiko Kasahara5), Noriko Yamaguchi6), Ryosuke Sato6), Takayuki Fukuda6), Alessandro Wataru Amici7), Masakazu Kato7), Takashi Omori2)
1)National Institute of Health Sciences, 2)Kobe University School of Medicine, 3)Doshisha University, 4)Drug Safety Testing Center Co., Ltd., 5)Fujifilm Corporation, 6)BOZO Research Center Inc,, 7)Japan Tissue Engineering Co., Ltd.
Alternatives to Animal Testing and Experimentation 22 (suppl) 87-87, 2017.
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P-66 Establishment and application of immortalized human epidermal keratinocytes as an in vitro alternative for skin irritation test
Cho-Won Kim1), Eui-Bae Jeung2), Kyung-Chul Choi1)
1)Laboratory of Biochemistry and Immunology, 2)Laboratory of Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 88-88, 2017.
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P-67 Development of a novel in chemico alternative test method for skin sensitization (ADRA) without using molecular weight for test chemical solution
Yusuke Yamamoto, Toshihiko Kasahara, Yasuhiro Katsuoka, Masaharu Fujita
Safety Evaluation Center, Ecology&Quality Management Division, Csr Division
Alternatives to Animal Testing and Experimentation 22 (suppl) 88-88, 2017.
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P-68 Study of factorial analysis and countermeasure of oxidation of Cys-derivative reagent (NAC) using in the ADRA (Amino acid Derivative Reactivity Assay) as the alternative test method for skin sensitization.
Masaharu Fujita1), Yusuke Yamamoto1), Shinichi Watanabe2), Tsunetsugu Sugawara2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Kei Kusakari5), Yoshihiko Kurokawa5), Tuyoshi Kawakami6), Kohichi Kojima7), Hajime Kojima8), Atsushi Ono9), Toshihiko Kasahara1)
1)Safety Evaluation Center, Ecology and Quality Management Division, CSR Division, FUJIFILM Corporation, 2)LION Corporation, HUMAN and ENVIRONMENTAL SAFETY EVALUATION CENTER, 3)MITSUI CHEMICALS, INC, Chemical Safety Department Responsible Care and Quality Assurance Division, 4)SUMITOMO CHEMICAL Co., Ltd. , Environmental Health Science Laboratory, 5)NISSAN CHEMICAL INDUSTRIES, LTD., Toxicology and Environmental Science Department Biological Research Laboratories, 6)National Institute of Health Sciences, Division of Environmental Chemistry, 7)Food and Drug Safety Center, Hadano Research Institute, 8)National Institute of Health Sciences, Biological Safety Research Center, 9)Okayama University, Graduate school of medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 89-89, 2017.
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P-69 The effect of the changes in the prediction model of in vitro skin sensitization test ; SH test
Nana Kuwata, Morihiko Hirota, Hayato Nishida, Hirokazu Kouzuki
SHISEIDO CO., LTD
Alternatives to Animal Testing and Experimentation 22 (suppl) 90-90, 2017.
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P-70 The feasibility of technology transfer of in vitro sensitization test, SH test (Part 3)
Akemi Toyoda1), Kaoru Kasahara1), Maki Sugiyama1), Masaharu Kurosawa2), Midori Takeyoshi2), Sakiko Aizawa2), Noriyasu Imai2), Morihiko Hirota3)
1)POLA Chemical Industries, inc., 2)KOSE Corporation, 3)Shiseido Global Innovation Center
Alternatives to Animal Testing and Experimentation 22 (suppl) 90-90, 2017.
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P-71 Predictive performance of in vitro skin sensitization assay using reconstructed human epidermis ; EpiSensA (Part1 ; Lipophilic chemicals)
Hideyuki Mizumachi1), Megumi Sakuma2), Noriyasu Imai2), Masaaki Miyazawa1)
1)Kao Corporation, Safety Science Research Laboratory, 2)KOSE Corporation, Fundamental Research Laboratories
Alternatives to Animal Testing and Experimentation 22 (suppl) 91-91, 2017.
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P-72 Predictive performance of in vitro skin sensitization assay using reconstructed human epidermis ; EpiSensA (Part2 ; Pre / pro-haptens)
Megumi Sakuma1), Hideyuki Mizumachi2), Masaaki Miyazawa2), Noriyasu Imai1)
1)KOSE Corporation, Fundamental Research Laboratories,, 2)Kao Corporation, Safety Science Research Laboratory
Alternatives to Animal Testing and Experimentation 22 (suppl) 91-91, 2017.
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P-73 Development of in vitro skin sensitization test method based on Nrf2-keap1-ARE pathway with transient expression system
Yosuke Maeda1),2), Haruka Hirosaki1), Hidenori Yamanaka1), Makoto Nakai2), Masahiro Takeyoshi1), Hiroyuki Iwata2)
1)Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute, 2)The United Graduate School of Veterinary Science, Yamaguchi University
Alternatives to Animal Testing and Experimentation 22 (suppl) 92-92, 2017.
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P-74 Safety assessment for skin sensitization by plants extracts using modified h-CLAT I. - high-concentration short term exposure method -
Yuimi Matsuoka1), Tomohisa Yoshimura1), Tohru Nagahama1), Hiroyuki Kojima2), Makoto Tsuboi2), Hiroshi Itagaki3)
1)TAISHO PHARMACEUTICAL Co., Ltd., 2)ICHIMARU PHARCOS Co., Ltd., 3)Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 92-92, 2017.
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P-75 Safety assessment for skin sensitization by plant extracts using modified h-CLAT II. Using extract models containing chemicals from natural sources
Yuki Ishii, Kazuto Narita, Hiroshi Itagaki
Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 93-93, 2017.
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P-76 Study of linalool-containing essential oil using skin sensitization test alternative method
Maki Doi1),2), Hideto Ariumi1), Yuji Yoshiyama1)
1)Kitasato University School of Pharmacy, 2)Pharmaholding Corporation
Alternatives to Animal Testing and Experimentation 22 (suppl) 93-93, 2017.
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P-77 Influence of culture medium and cell-cell interactions between THP-1 cells and NHEK cells on the expression of protein markers of immunotoxicity
Yuka Sawada, Hanae Tsukumo, Junji Fukuda, Hiroshi Itagaki
Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 94-94, 2017.
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P-78 Development of an In Vitro Test for the Allergenic Potency of Proteins I. Investigation of false positive reactions
Dan Xie1), Hanae Tsukumo1),2), Kunihiko Yamashita3), Hajime Kojima2), Hiroshi Itagaki1)
1)Yokohama National University, 2)National Institute of Health Sciences, 3)DAICEL Corporation
Alternatives to Animal Testing and Experimentation 22 (suppl) 94-94, 2017.
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P-79 Development of an In Vitro Test for the Allergenic Potency of Proteins II. Exclusion of the effect of LPS in test proteins
Hanae Tsukumo1),2), Dan Xie1), Kunihiko Yamashita3), Hajime Kojima2), Hiroshi Itagaki1)
1)Yokohama National University, 2)National Institute of Health Sciences, 3)DAICEL Corporation
Alternatives to Animal Testing and Experimentation 22 (suppl) 95-95, 2017.
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P-80 Development of an In Vitro Test for the Allergenic Potency of Proteins III. Investigation of the usefulness of differentiated THP-1 cells
Akane Oka, Hanae Tsukumo, Shinichi Ogata, Hiroshi Itagaki
Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 95-95, 2017.
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P-81 In vitro detection for protein allergen inducing type 1 allergy via the skin route
Yasutaka Kuroda1),2), Takuo Yuki1), Yutaka Takahashi1), Hitoshi Sakaguchi1), Kayoko Matsunaga3), Hiroshi Itagaki2)
1)Kao corporation Safety Science Research Laboratories, 2)Yokohama National University Graduate School of Engineering, 3)Fujita Health University School of Medicine Department of Integrative Medical Science for Allergic Disease
Alternatives to Animal Testing and Experimentation 22 (suppl) 96-96, 2017.
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P-82 Second report on reducing false negative results of an in vitro skin sensitization test-human cell line activation test
Kazuto Narita1),2), Yuuki Ishii1), Hajime Kojima2), Hiroshi Itagaki1)
1)Yokohama National University, 2)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 96-96, 2017.
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P-83 The effects of mixtures of chemicals on in vitro skin Sensitization test II
Minori Mezaki, Takafumi Mitachi, Mai Kouzui, Ryo Maruyama, Hiroshi Itagaki
Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 97-97, 2017.
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P-84 Effect of intracellular ROS on h-CLAT
Ryo Maruyama, Takafumi Mitachi, Minori Mezaki, Mai Kouzui, Hiroshi Itagaki
Yokohama National University
Alternatives to Animal Testing and Experimentation 22 (suppl) 97-97, 2017.
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P-85 Examination of the influence of NLRP3 inflammasome in in vitro skin sensitization test
Mai Kouzui1), Takafumi Mitachi1), Minori Mezaki1), Ryo Maruyama1), Hajime Kojima2), Hiroshi Itagaki1)
1)Yokohama National University, 2)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 98-98, 2017.
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P-86 Study on key factors that influence the CD86 and CD54 expression in THP-1 cells
Takafumi Mitachi1), Minori Mezaki1), Mai Kouzui1), Ryo Maruyama1), Hajime Kojima2), Hiroshi Itagaki1)
1)Yokohama National University, 2)National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 98-98, 2017.
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P-87 Skin sensitization studies by quantitative structure-activity relationships (QSAR) approach
Kazuhiro Sato1), Jose Ciloy2), Yukinori Kusaka1)
1)Department of Environmental Health, School of Medicine, University of Fukui, 2)Fujitsu Kyushu System Services Limited
Alternatives to Animal Testing and Experimentation 22 (suppl) 99-99, 2017.
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P-88 A novel in vitro assay for sensitisers in a purely aqueous system : the modified IL-8 Luc assay using X-VIVOTM 15 as a solvent
Yutaka Kimura1), Mika Watanabe2), Noriyuki Suzuki3), Tomoko Iwaki4), Kohji Yamakage2), Koichi Saito5), Yoshihiro Nakajima4), Chizu Fujimura1), Yoshihiro Ohmiya6), Takashi Omori7), Hajime Kojima8), Setsuya Aiba1)
1)Department of Dermatology, Tohoku University Graduate School of Medicine, 2)Hatano Research Institute, Food and Drug Safety Center, 3)Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 4)Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 5)Advanced Materials Development Laboratory, Sumitomo Chemical Co., Ltd., 6)Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 7)Division of Biostatistics, Department of Social / Community Medicine and Health Science, Kobe University School of Medicine, 8)Japanese Center for the Validation of Alternative Methods, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 22 (suppl) 99-99, 2017.
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R-1 Report of International committee in JSAAE
Hajime Kojima1), Kurosawa Tsutomu2),9), Suzuki Makoto3), Takeyoshi Masahiro4), Kanda Yasunari1), Takeuchi Sanae5), Sakuma Megumi6), Nakamura Maki7), Sozu Takashi8)
1)National Institute of Health Sciences, 2)Kagoshima University, 3)Okinawa International University, 4)Chemicals Evaluation and Research Institute, 5)P&G Japan, 6)KOSE Corporation, 7)Kobayashi Pharmaceutical Co., Ltd., 8)Tokyo Univ. Sci., 9)Animal Welfare Research Japan
Alternatives to Animal Testing and Experimentation 22 (suppl) 100-100, 2017.
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