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Alternatives to Animal Testing and Experimentation 27巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN（オンライン）
2185-4726
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開始頁
SL-1. Utilization of biomarkers for detection and prediction of transporter-mediated drug interaction risk
Hiroyuki Kusuhara
Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 84-84, 2022.
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SL-2. Promotion of proper conduct of animal experiments
Ichiro Miyoshi
Institute for Animal Experimentation, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 27 (suppl) 84-84, 2022.
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SL-3. Data-driven drug discovery and healthcare by AI
Yoshihiro Yamanishi
Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology
Alternatives to Animal Testing and Experimentation 27 (suppl) 85-85, 2022.
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EL. Past and future of research on alternative methods for animal experiments in Japan : Wen old wisdom new about 35 years of research on alternative methods
Hiroshi Itagaki
President of JSAAE
Alternatives to Animal Testing and Experimentation 27 (suppl) 85-85, 2022.
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S1-1. Update on skin sensitisation and safety evaluation
David Basketter
DABMEB Consultancy Ltd.
Alternatives to Animal Testing and Experimentation 27 (suppl) 86-86, 2022.
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S1-2. Introduction of validation study for new in chemico spectro-DPRA developed in Korea
Bae-Hwan Kim
Keimyung University
Alternatives to Animal Testing and Experimentation 27 (suppl) 86-86, 2022.
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S1-3. Experimentally validated in-silico approach to predict the skin sensitization potential of phytochemicals
Rahul Date, Bharath Rudresh, Priyanka Mishra, Nitin Patel, Vaibhav Barot, Kirti Shitiz, Fatima Khan, Ashita Desai, Abhishek Tater, Abhay Deshpande
Jai Research Foundation
Alternatives to Animal Testing and Experimentation 27 (suppl) 87-87, 2022.
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S1-4. Establishment and international harmonization of photosafety testing strategy
Satomi Onoue
Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 27 (suppl) 87-87, 2022.
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S1-5. JSAAE strategy for international cooperation
Hajime Kojima
International Committee, JSAAE, National Institute of Health Sciences (NIHS), Hatano Research Institute (HRI), Food and Drug Safety Center (FDSC)
Alternatives to Animal Testing and Experimentation 27 (suppl) 88-88, 2022.
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S2-1. In silico modeling & simulation for efficient inhalation toxicity testing on chemicals
Kohei Yamada1), Atsushi Kambayashi1,2), Hideyuki Sato1), Satomi Onoue1)
1)Laboratory of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka, 2)Pharmaceutical Research and Technology Labs, Astellas Pharma. Inc.
Alternatives to Animal Testing and Experimentation 27 (suppl) 88-88, 2022.
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S2-2. Prediction of internal concentrations of chemicals using data-driven pharmacokinetic modeling
Hiroshi Yamazaki
Showa Pharmaceutical University
Alternatives to Animal Testing and Experimentation 27 (suppl) 89-89, 2022.
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S2-3. Modeling & simulation approach for prediction of pharmacokinetics of antibody drugs
Kazuhisa Ozeki
Chugai Pharmaceutical Co., Ltd. Translational Research Division
Alternatives to Animal Testing and Experimentation 27 (suppl) 89-89, 2022.
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S2-4. Predicting the in vivo performance of oral dosage forms using a modeling and simulation approach
Atsushi Kambayashi
Pharmaceutical Research and Technology Labs, Astellas Pharma Inc.
Alternatives to Animal Testing and Experimentation 27 (suppl) 90-90, 2022.
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S3-1. Neurotoxicity assessment of compounds based on in vitro neural activity
Ikuro Suzuki
Graduate School of Engineering, Tohoku Institute of Technology
Alternatives to Animal Testing and Experimentation 27 (suppl) 90-90, 2022.
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S3-2. Evaluation of developmental neurotoxicity of chemical substances by a read-across method using chemical structure information
Kouichi Yoshinari
School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 27 (suppl) 91-91, 2022.
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S3-3. Current status and challenges of developmental neurotoxicity testing using zebrafish
Yuhei Nishimura
Department of Integrative Pharmacology, Mie University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 27 (suppl) 91-91, 2022.
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S3-4. Current status and future perspectives in in vitro neurotoxicity
Yasunari Kanda, Yukuto Yasuhiko
National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 91-91, 2022.
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S4-1. Update of immunotoxicology : new approach methodologies with a focus on immunosuppression
Emanuela Corsini
Laboratory of Toxicology, Department of Pharmacological and Biomolecular Sciences, School of Pharmacy, Universita degli Studi di Milano
Alternatives to Animal Testing and Experimentation 27 (suppl) 92-92, 2022.
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S4-2. AOP development of immunotoxicity in OECD AOP programme
Kiyoshi Kushima
Subcommittee for AOP Development, the Japanese Society of Immunotoxicology
Alternatives to Animal Testing and Experimentation 27 (suppl) 92-92, 2022.
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S4-3. Development of a Detailed Review Paper (DRP) on non-animal approaches for immunosuppression
Barbara Kaplan
Mississippi State University
Alternatives to Animal Testing and Experimentation 27 (suppl) 93-93, 2022.
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S4-4. Expanding possibilities for Multi-Immuno Tox assay
Setsuya Aiba
Matsuda Hospital
Alternatives to Animal Testing and Experimentation 27 (suppl) 93-93, 2022.
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S6-1. Practical use of alternative methods to animal testing in drug development - Mainly for drug candidate compound selection -
Kazunori Fujimoto
Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.
Alternatives to Animal Testing and Experimentation 27 (suppl) 94-94, 2022.
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S6-2. Current status and issues for the use of alternative methods in the field of food
Yuichi Ito
International Life Sciences Institute (ILSI) Japan
Alternatives to Animal Testing and Experimentation 27 (suppl) 95-95, 2022.
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S6-3. Conducting alternative testing method for the Pesticide Control Act
Tadashi Kosaka
Toxicology Division, Institute of Environmental Toxicology
Alternatives to Animal Testing and Experimentation 27 (suppl) 95-95, 2022.
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S6-4. Current status and issues of alternative method utilization in cosmetics OEM / ODM
Nishiura Hideki
NIHON KOLMAR CO., LTD.
Alternatives to Animal Testing and Experimentation 27 (suppl) 95-95, 2022.
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S6-5. Current status and issues of alternative method utilization in the CRO industry
Takayuki Fukuda
Tokyo Laboratory, BoZo Research Center Inc.
Alternatives to Animal Testing and Experimentation 27 (suppl) 96-96, 2022.
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S7-1. Contribution to the 3Rs through the use of e-learning in the education of laboratory animal technicians
Mariko Amano, Hironari Koyama
KAC Co., Ltd.
Alternatives to Animal Testing and Experimentation 27 (suppl) 96-96, 2022.
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S7-2. "Contents for Ethics Training on Animal Experiments" funded by the JH Research Promotion Fund
Noboru Ogiso
National Center for Geriatrics and Gerontology
Alternatives to Animal Testing and Experimentation 27 (suppl) 97-97, 2022.
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S7-3. Development and consideration of educational contents related to animal experiments
Ryuichi Miura
Office for Life Science Research Ethics and Safety, The University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 97-97, 2022.
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S8-1. Expectations and challenges for New Generation Risk Assessment (NGRA)
Morihiko Hirota
Brand Value R&D Institute, Shiseido Co., Ltd. / Japan Cosmetic Industry Association
Alternatives to Animal Testing and Experimentation 27 (suppl) 98-98, 2022.
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S8-2. Prediction of skin permeation of chemicals based on exposure scenario
Hiroaki Todo
Josai University
Alternatives to Animal Testing and Experimentation 27 (suppl) 98-98, 2022.
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S8-3. Consideration for safety assessment methods by NAM based on experience with in vivo toxicity studies
Yuhji Taquahashi
Animal Care Section, Division of Cellular and Molecular Toxicology, Center for Biological Safety & Research, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 99-99, 2022.
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S8-4. Development of Next-Generation Risk Assessment (NGRA) case study and considerations for regulatory acceptance
Takashi Yamada
Division of Risk Assessment, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 99-99, 2022.
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S9-1. Importance of image-based status monitoring for enabling iPS cell culture under QbD
Ryuji Kato
Nagoya University, Graduate School of Pharmaceutical Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 100-100, 2022.
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S9-2. Risk assessment of drug-induced arrhythmia using human iPS cell-derived cardiomyocytes
Junko Kurokawa
Department of Bio-informational Pharmacology, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 27 (suppl) 100-100, 2022.
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S9-3. Development of human iPS cell derived-brain microvascular endothelial cells in the BBB model for application in drug development
Tadahiro Hashita
Graduate School of Pharmaceutical Sciences, Nagoya City University
Alternatives to Animal Testing and Experimentation 27 (suppl) 101-101, 2022.
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S9-4. Toward in vitro reconstitution of brain function using organoids derived from monkey and human pluripotent stem cells
Fumitaka Osakada
Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University
Alternatives to Animal Testing and Experimentation 27 (suppl) 101-101, 2022.
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A-1. Development of LLNA : DA
Kunihiko Yamashita
Industry Business Unit, Safety Strategic Business Unit, Daicel Corporation / Department of Device Application for Molecular Therapeutics, Graduate School of Medicine, Osaka University
Alternatives to Animal Testing and Experimentation 27 (suppl) 102-102, 2022.
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A-2. Construction of 3D-Living Tissues for Alternatives to Animals Experiments using Layer-by-Layer Methods on Affinity Interactions between ECM Proteins
Mitsuru Akashi
Osaka University
Alternatives to Animal Testing and Experimentation 27 (suppl) 102-102, 2022.
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M-0. Mandom International Research Grants on Alternative to Animal Experiments
Hidefumi Ikeda
Mandom Corporation, Product Evaluation Institute
Alternatives to Animal Testing and Experimentation 27 (suppl) 103-103, 2022.
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M-1. Development of an alternative evaluation system for the potential of mitochondrial permeability transition using human-isolated platelets
Akinori Takemura
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 27 (suppl) 103-103, 2022.
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M-2. Vascular endothelial spheroid as an evaluation tool for inflammatory response
Sanshiro Hanada
Department of Clinical Engineering, Faculty of Medical Science and Technology, Gunma Paz University
Alternatives to Animal Testing and Experimentation 27 (suppl) 104-104, 2022.
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M-3. Development of alternatives to animal testing for predicting the health effects of chemicals on the human fetus
Takeshi Hori
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Alternatives to Animal Testing and Experimentation 27 (suppl) 104-104, 2022.
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P-01. False negative chemicals in ESR based photosafety test (ESR-PT) and their significances on photosafety evaluations
Masumi Hinoshita1), Takayuki Abe2), Yosuke Maeda3), Masahiro Takeyoshi3)
1)CERI Osaka, Chemicals Evaluation and Research Institute, 2)CERI Tokyo, Chemicals Evaluation and Research Institute, 3)Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute
Alternatives to Animal Testing and Experimentation 27 (suppl) 106-106, 2022.
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P-02. Micellar Reactive Oxygen species (ROS) assay using Acetonitrile for poorly water-soluble chemicals
Toshiyuki Ohtake
Brand Value R&D Institute, Shiseido Co., Ltd.
Alternatives to Animal Testing and Experimentation 27 (suppl) 106-106, 2022.
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P-03. Read-across based on chemical structure information and non-animal test methods for skin sensitization potency prediction
Kanako Nakayama, Taisuke Kawamoto, Masaaki Miyazawa
Kao Corporation
Alternatives to Animal Testing and Experimentation 27 (suppl) 107-107, 2022.
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P-04. Development of a method for evaluating inhalation toxicity potential of nanomaterials in a co-culture system of human bronchial epithelial cells and THP-1 cells
Asuka Nishida1), Takao Ashikaga2), Akiko Ohno2), Kazutoshi Iijima3)
1)Graduate School of Engineering Science, Yokohama National University, 2)Division of Risk Assessment, Center for Biological Safety & Research, National Institute of Health Sciences, 3)Faculty of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 27 (suppl) 107-107, 2022.
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P-05. Improvement and performance of highly accurate and simple KE-2 test method α-Sens(R)
Yosuke Maeda, Masahiro Takeyoshi
Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute
Alternatives to Animal Testing and Experimentation 27 (suppl) 108-108, 2022.
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P-06. Search for novel inhibitors of atopic dermatitis using human keratinocyte cell lines as a model of atopic dermatitis
Ayano Satoh1), Kosuke Kato1), Yoshio Tsujino2)
1)Okayama University, 2)Kobe University
Alternatives to Animal Testing and Experimentation 27 (suppl) 108-108, 2022.
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P-07. Evaluation of predictive performance of the combination approaches for Skin Sensitization using a new KE-2 test method α-Sens(R)
Masaru Suzuki1), Mayuko tomisawa1), Saori Fujishima1), Yosuke Maeda2), Masahiro Takeyoshi2)
1)CERI Hita, Chemicals Evaluation and Research Institute, 2)Chemicals Assessment and Research Center, Chemicals Evaluation and Research Institute
Alternatives to Animal Testing and Experimentation 27 (suppl) 109-109, 2022.
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P-08. Improvement of the chromophore solid phase peptide reaction assay (C-SPRA) for rapid safety assessment as alternatives to animal testing
Kenji Usui1), Masae Fukuda1), Aki Nishimura1), Fumihiro Kayamori1), Yoshio Hamada1), Hideto Ariumi2)
1)Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 2)Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University
Alternatives to Animal Testing and Experimentation 27 (suppl) 109-109, 2022.
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P-09. Development of high-sensitivity detection reagents for trace skin sensitizers to improve the accuracy of skin sensitization test methods and identify positive causes
Masataka Kitadani1), Yohei Shimizu1), Hideyuki Mizumachi2), Taku Nishijo2), Takuo Yuki2), Akihiro Moriuchi1), Ryo Koike1)
1)Kao Corporation, Analytical Science Research Laboratories, 2)Kao Corportaion, Safety Science Research Laboratories
Alternatives to Animal Testing and Experimentation 27 (suppl) 110-110, 2022.
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P-10. Development of high-sensitivity detection reagents for trace skin sensitizers to improve the precision of skin sensitization tests : Evaluation using known sensitizers
Yohei Shimizu1), Masataka Kitadani1), Hideyuki Mizumachi2), Taku Nishijo2), Takuo Yuki2), Akihiro Moriuchi1), Ryo Koike1)
1)Kao Corporation, Analytical Science Research Laboratories, 2)Kao Corportaion, Safety Science Research Laboratories
Alternatives to Animal Testing and Experimentation 27 (suppl) 110-110, 2022.
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P-11. Useful ADRA fuorescence method to evaluate the skin sensitization potential of dyes
Kota Hatano, Nodoka Takahashi, Shiho Horiguchi, Honoka Iwasa, Nobuaki Nakamura
Hoyu Co., Ltd.
Alternatives to Animal Testing and Experimentation 27 (suppl) 111-111, 2022.
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P-12. Development of machine learning model to predict human skin sensitization potential using chemical structure information
Jun Ito1), Kaori Ambe1), Takao Ashikaga2), Masahiro Tohkin1)
1)Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 2)Division of Risk Assessment, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 111-111, 2022.
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P-13. Evaluation and mechanistic analysis of adjuvant effect of nanomaterials using h-CLAT
Rion Arai1), Takao Ashikaga2), Akiko Ohno2), Kazutoshi Iijima3)
1)Department of Science and Engineering, Yokohama National University, 2)Division of Risk Assessment, Center for Biological Safety & Research, National Institute of Health Sciences, 3)Faculty of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 27 (suppl) 112-112, 2022.
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P-14. Exploring new index in the evaluation of nanomaterials to activate antigen-presenting cells using THP-1 cells
Kazutoshi Iijima1), Miho Suzuo2), Maki Yamashiro3), Akiko Ohno4), Takao Ashikaga4)
1)Faculty of Engineering, Yokohama National University, 2)College of Engineering Science, Yokohama National University, 3)Graduate School of Engineering Science, Yokohama National University, 4)Division of Risk Assessment, Center for Biological Safety & Research, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 112-112, 2022.
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P-15. Ring study of ADRA, in chemico alternative test method for skin sensitization, aimed at revised guideline
Kazuya Takeuchi1), Kohei Kamiya1), Shinichi Watanabe2), Hiroaki Yamaga2), Koji Wakabayashi3), Yu Tahara3), Nobuyuki Horie4), Keiichi Fujimoto4), Tsuyoshi Kawakami5), Kohichi Kojima6), Takashi Sozu7), Hajime Kojima6)8), Yusuke Yamamoto9), Masaharu Fujita9), Toshihiko Kasahara9), Atsushi Ono10)
1)Biological Research Laboratories, Nissan Chemical Corporation, 2)Safety Science Research Laboratories, Lion Corporation, 3)Chemical Safety Department, Mitsui Chemicals, Inc., 4)Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 5)Division of Environmental Chemistry, National Institute of Health Sciences, 6)Hatano Research Institute, Food and Drug Safety Center, 7)Faculty of Engineering, Tokyo University of Science, 8)National Institute of Health Sciences, 9)Safety Evaluation Center, Fujifilm Corporation, 10)Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Division of Pharmaceutical Sciences, Okayama University
Alternatives to Animal Testing and Experimentation 27 (suppl) 113-113, 2022.
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P-16. The applicability of ADRA in predicting skin sensitization by combining multiple alternative methods for the OECD DASS chemical set
Natsumi Nakashima1), Yusuke Yamamoto1), Sayaka Wanibuchi1), Hajime Kojima2)3), Atsushi Ono4), Kazuhiko Matsumoto5), Masaharu Fujita1), Toshihiko Kasahara1)
1)Fujifilm Corporation, Safety Evaluation Center, 2)National Institute of Health Sciences, 3)Hatano Research Institute, Food and Drug Safety Center, 4)Faculty of Pharmaceutical Sciences, 5)Nagoya City University, Graduate School of Medical Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 114-114, 2022.
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P-17. Assessment of commercial polymers with and without reactive groups using Amino acid Derivative Reactivity Assay (ADRA) based on both molar concentration approach and gravimetric approach
Sayaka Wanibuchi1), Masaharu Fujita1), Natsumi Nakashima1), Yusuke Yamamoto1), Hajime Kojima2)3), Atsushi Ono4), Toshihiko Kasahara1)
1)Safety Evaluation Center, Ecology & Quality Management Division, ES G Division, 2)National Institute of Health Sciences, Kanagawa, 3)Hatano Research Institute, Food and Drug Safety Center, 4)Faculty of Pharmaceutical Sciences, Okayama
Alternatives to Animal Testing and Experimentation 27 (suppl) 114-114, 2022.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-18. Skin-whitening ingredient Rhododendrol induces up-regulating of costimulatory molecule CD86 on dendritic cells through ROS generation and extrracellular ATP production in melanocytes
Yasuhiro Katahira, Eri Sakamoto, Yuma Furusaka, Aruma Watanabe, Ami Sekine, Miu Yamagishi, Jukito Sonoda, Hideaki Hasegawa, Izuru Mizoguchi, Takayuki Yoshimoto
Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University
Alternatives to Animal Testing and Experimentation 27 (suppl) 115-115, 2022.
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P-19. Evaluation of craniofacial anomalies by detection of neural crest cells disruption
Shujie Liu1), Toru Kawanishi2), Atsuko Shimada2), Keita Yoshihara1), Takashi Ieki1), Naohiro Ikeda1), Hiroyuki Takeda2), Junichi Tasaki1)
1)Kao Corporation, 2)Department of Biological Sciences Graduate School of Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 115-115, 2022.
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P-20. Challenges to Compromise in Safety Evaluation on Cosmetics with Threshold of Toxicological Concern and Read-Across
Taisuke Kawamoto1), Anne Fuchs2), Rolf Fautz2), Osamu Morita1), Anne Zifle2), James Rathman3), Aleksandra Mostrag4), Chihae Yang4), Masaaki Miyazawa1)
1)Safety Science Research, Kao Corporation, 2)Safety & Toxicology, Kao Germany GmbH, 3)The Ohio State University, 4)MN-AM
Alternatives to Animal Testing and Experimentation 27 (suppl) 116-116, 2022.
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P-21. Associations between repeated dose toxicity and in silico proflers or metabolic simulators used for chemical grouping
Michiko Watanabe, Yuki Sakuratani, Shino Kuwa, Ruriko Nakamura, Takeshi Morita, Yuko Obara
Chemical Management Center, National Institute of Technology and Evaluation
Alternatives to Animal Testing and Experimentation 27 (suppl) 116-116, 2022.
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P-22. Construction of a bile canaliculus-like structure using sandwich-cultured cryopreserved human hepatocytes for predicting biliary excretion of food-derived compounds in vitro
Takashi Kitaguchi1), Shinichiro Horiuchi2), Yukie Kuroda2), Katsutoshi Ohno1), Kazuhiro Kobayash1), Mitsuru Tanaka1), Seiichi Ishida2)3)
1)Global Food Safety Institute, Nissin Foods Holdings Co., Ltd., 2)Division of Pharmacology, National Institute of Health Sciences, 3)Division of Applied Life Science, Graduate School of Engineering, Sojo University
Alternatives to Animal Testing and Experimentation 27 (suppl) 117-117, 2022.
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P-23. Comparison of bile canaliculi formation between donors and improvement of biliary effux ability toward the development of in vitro biliary excretion assay
Shinichiro Horiuchi1), Yukie Kuroda1), Daiju Yamazaki1), Seiichi Ishida1)2)
1)Division of Pharmacology, National Institute of Health Sciences, 2)Division of Applied Life Science, Graduate School of Engineering, Sojo University
Alternatives to Animal Testing and Experimentation 27 (suppl) 117-117, 2022.
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P-24. Accuracy improvement of in silico transdermal absorption rate prediction model
Shinya Iwanaga1), Masaaki Mori1), Tomoka Hisaki1), Takumi Nukaga1), Hirokazu Kozuki2), Akiko Tamura1)
1)Brand Value R & D Institute, Shiseido Co., Ltd., 2)MIRAI Technology Institute, Shiseido Co., Ltd.
Alternatives to Animal Testing and Experimentation 27 (suppl) 118-118, 2022.
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P-25. Development of a mathematical model for predicting percutaneous absorption of chemicals applied as fnite dose and the limitation of applicability of the mathematical model in the case of incorporating alternative skin membranes
Ryoki Kunita1), Takafumi Nishijima1), Masaaki Miyazawa2), Hiroaki Todo3), Kenji Sugibayashi4), Hitoshi Sakaguchi1)
1)Kao corporation, Kanagawa, 2)Kao corporation, Tochigi, 3)Faculty of Pharmaceutical Sciences, Josai University, 4)Josai International University
Alternatives to Animal Testing and Experimentation 27 (suppl) 118-118, 2022.
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P-26. Liver-small intestine drug metabolism-related crosstalk in vitro using on-chip perfused and direct oxygenated microphysiological system (MPS)
Kurniawan Dhimas1), Inamura Kousuke1), Danoy Mathieu1), Leo Sylvia2), Inamatsu Mutsumi3), Funaoka Sohei4), Aihara Daichi4), Sakura Takeshi4), Arakawa Hirosh5), Kato Yukio5), Matsugi Tomoaki1), Esashika Katsuhiro6), Nishikawa Masaki1), Shiraki Nobuaki2), Kume Shoen2), Kimura Hiroshi7)
1)Graduate School of Engineering, The University of Tokyo, 2)School of Life Science and Technology, Tokyo Institute of Technology, 3)PhoenixBio Co. Ltd., 4)Sumitomo Bakelite Co. Ltd., 5)Faculty of Pharmacy Institute of Medical, Pharmaceutical and Health Science, Kanazawa University, 6)Mitsui Chemicals Inc., 7)Department of Mechanical Engineering, Tokai University
Alternatives to Animal Testing and Experimentation 27 (suppl) 119-119, 2022.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-27. Molecular pathological analysis of cancer cell clusters formed due to the loss of scaffold attachment
Kouhei Sakurai1), Akira Nagai2), Masaharu Akita3), Tatsuya Ando1), Yasuhiro Sakai1), Taku Kato1), Hiroyasu Ito1)
1)Department of Joint Research Laboratory of Clinical Medicine, School of Medicine, Fujita Health University, 2)Student Researcher Program, School of Medicine, Fujita Health University, 3)Department of Nutrition and Dietetics, School of Family and Consumer Sciences, Kamakura Women's University
Alternatives to Animal Testing and Experimentation 27 (suppl) 119-119, 2022.
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P-28. Evaluation for inhibitory effects of hybrid liposomes on the growth of breast cancer stem cells
Riko Jinno1), Yuji Komizu1), Hideaki Ichihara1), Yoko Matsumoto1), Taku Matsushita1), Seiichi Ishida1)2)
1)Division of Applied Life Science, Graduate School of Engineering, Sojo University, 2)Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 120-120, 2022.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-29. Statistical methods for binary-scale precision experiments and their international standardization
Jun-ichi Takeshita1), Tomomichi Suzuki2)
1)Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST), 2)Faculty of Science and Technology, University of Science
Alternatives to Animal Testing and Experimentation 27 (suppl) 120-120, 2022.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-30. Construction and application of human cultured tissue with autonomic nervous system
Yuka Akagi1)2), Yuzo Takayama1), Yutaro Kumagai1), Yasuyuki S. Kida1)3)
1)Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2)Tsukuba Life Science Innovation Program (T-LSI) School of Comprehensive Human Sciences, University of Tsukuba, 3)School of Integrative and Global Majors, University of Tsukuba
Alternatives to Animal Testing and Experimentation 27 (suppl) 121-121, 2022.
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P-31. Seesaw-driven in vitro intestinal model involving co-culture with E. coli
Naoya Ito, Junji Fukuda, Toshihiro Usui, Mioto Nishino
Graduate school of Engineering Science, Yokohama National University
Alternatives to Animal Testing and Experimentation 27 (suppl) 121-121, 2022.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-32. Development of iPS cardiomyocyte 3D micro tissues for cardiotoxicity by using the pin-type bioprinter
Shohei Chikae1)2), Yoshinari Tsukamoto1)2), Atsushi Oda1)2), Takuji Kobayashi2)
1)NTN Corporation, 2)NTN Next Generation Research Alliance Laboratories, Graduate School of Engineering, Osaka University
Alternatives to Animal Testing and Experimentation 27 (suppl) 122-122, 2022.
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P-33. Development of 3D skin model that enables functional evaluation of cosmetic ingredients and skin care products
Katsunari Tezuka, Hiroaki Shichiri
Skinscience Laboratory, Ands Corporation
Alternatives to Animal Testing and Experimentation 27 (suppl) 122-122, 2022.
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P-34. 3D culture of human induced pluripotent stem cell-derived cardiomyocytes for cardiotoxicity assessment
Takeshi Sekiwa, Keiichiro Oiso, Junji Fukuda
Graduate School of Engineering Science, Yokohama National University
Alternatives to Animal Testing and Experimentation 27 (suppl) 123-123, 2022.
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P-35. Coculture of A549 cells and HepaRG cells on highly oxygen-permeable plates
Shinnosuke Chuman, Shinkichi Ishikawa
JAPAN TOBACCO INC. Scientific Product Assessment Center
Alternatives to Animal Testing and Experimentation 27 (suppl) 123-123, 2022.
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P-36. Functional maintenance of cultured hepatocytes by using E-cadherin coated plate
Rieko Tanaka, Kazuko Aizawa, Kazuaki Nakamura
Department of Pharmacology, National Center for Child Health and Development
Alternatives to Animal Testing and Experimentation 27 (suppl) 124-124, 2022.
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P-37. Compartmentalized three-dimensional human neuromuscular tissue models for in vitro analysis of neuromuscular diseases
Yuhei Kamei, Ayumu Matsushima, Kazuki Yamamoto, Hirokazu Akiyama, Hiroyuki Honda, Kazunori Shimizu
School of Engineering, Nagoya University
Alternatives to Animal Testing and Experimentation 27 (suppl) 124-124, 2022.
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P-38. In silico model for predicting skin permeation of substances after its fnite dose application
Ibuki Narita1), Chihiro Fujiwara1), Shouko Itakura1), Kenji Sugibayashi2), Hiroaki Todo1)
1)School of Pharmaceutical Sciences, University of Josai, 2)Josai International University
Alternatives to Animal Testing and Experimentation 27 (suppl) 125-125, 2022.
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P-39. Assessing the impact of dataset partitioning on the performance of machine learning to predict chemical toxicity
Tadahaya Mizuno, Katsuhisa Morita, Hiroyuki Kusuhara
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 125-125, 2022.
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P-40. In silico approach that supports neurotoxicity assessment of chemical substances by IATA : Refning categories by using substructures and physicochemical and biochemical parameters related to neurotoxicity
Takashi Yamada, Shinji Tsujii, Minoru Miura, Akiko Saito, Tomoko Kawamura, Taeko Maruyama, Naruo Katsutani, Akihiko Hirose
Division of Risk Assessment, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 126-126, 2022.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-41. Development of a machine learning model to improve effciency of in vitro assays for skin sensitization assessment
Kei Kinoshita1), Kaori Ambe1), Takao Ashikaga2), Masahiro Tohkin1)
1)Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 2)Division of Risk Assessment, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 126-126, 2022.
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P-42. Development of a read-across method for evaluating repeated-dose toxicity using molecular descriptors : Examination of methods of selecting molecular descriptors for better prediction
Yu Harakawa1), Nao Omura1), Jun-ichi Takeshita1)2), Ryota Shizu1), Takuomi Hosaka1), Yuichiro Kanno1), Kouichi Yoshinari1)
1)School of Pharmaceutical Sciences, University of Shizuoka, 2)Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 27 (suppl) 127-127, 2022.
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P-43. Development of an in silico model for the liver homeostasis breakdown and fbrosis
Masaki Nishikawa1), Misa Yoshizawa2), Masahiro Sugimoto3), Minoru Tanaka4), Yasuyuki Sakai1)
1)Department of Chemical System Engineering, University of Tokyo, 2)Frontier Research Center, POLA chemical industries, 3)Research and Development Center for Minimally Invasive Therapies, Medical Research Institute, Tokyo Medical University, 4)Department of Regenerative Medicine, Research Institute, National Center for Global Health and Medicine
Alternatives to Animal Testing and Experimentation 27 (suppl) 127-127, 2022.
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P-44. Investigation of read-across methods for predicting developmental neurotoxicity
Nao Omura, Ryota Shizu, Takuomi Hosaka, Yuichiro Kanno, Kouichi Yoshinari
School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 27 (suppl) 128-128, 2022.
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P-45. Construction of a layered 3D co-culture model as an alternative method for animal experiments in drug evaluation
Yuma Yokokawa1)2), Yuki Takahashi1)2), Shiro Kitano1), Eiji Shinozaki3), Ryohei Katayama2)4), Naoya Fujita2)
1)Technical Research Institute Toppan Inc., 2)Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3)The Cancer Institute Hospital Of JFCR, 4)Graduate School of Frontier Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 128-128, 2022.
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P-46. Anti-cancer drug screening with a unique layered 3D co-culture model
Yuki Takahashi1)2), Yuma Yokokawa1)2), Shiro Kitano1), Eiji Shinozaki3), Ryohei Katayama2)4), Naoya Fujita2)
1)Technical Research Institute, Toppan Inc., 2)Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3)The Cancer Institute Hospital of JFCR, 4)Graduate School of Frontier Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 129-129, 2022.
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P-47. Electrochemical analysis of intestinal models
Chisato Ito1), Kosuke Ino2), Kazuyuki Iwase3), Itaru Honma3), Hitoshi Shiku1)2)
1)Graduate School of Environmental Studies, Tohoku University, 2)Graduate School of Engineering, Tohoku University, 3)Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
Alternatives to Animal Testing and Experimentation 27 (suppl) 129-129, 2022.
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P-48. Construction of a screening system for assessing contractile force of in vitro human skeletal muscle atrophy models
Kazunori Shimizu, Hirokazu Akiyama, Hiroyuki Honda
Graduate School of Engineering, Nagoya University
Alternatives to Animal Testing and Experimentation 27 (suppl) 130-130, 2022.
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P-49. A novel system for air-liquid interface exposure of PM2.5 to human 3dimensional cultured epidermal model
Maori Kono1)2), Masayuki Takaishi1)2), Kazuhiko Kinoshita1), Hidefumi Ikeda1)2), Tomoaki Okuda3), Yasuhiro Ishihra4)
1)Mandom Corp., 2)Laboratory of Advanced Cosmetic Science, Graduate School of Pharmaceutical Sciences, Osaka University, 3)Faculty of Science and Technology, Keio University, 4)Program of Biomedical Science, Graduate School of Integrated
Alternatives to Animal Testing and Experimentation 27 (suppl) 130-130, 2022.
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P-50. A rapid OCT-based approach for vessel quantifcation of 3D blood-brain barrier model
Huiting Zhang1)2), Noriyuki Nakatani3), Daisuke Tominaga4), Marie Piantino2), Dong Hee Kang2), Tomomi Furihata5), Michiya Matsuzaki1)2), Satoshi Fujita1)2)
1)Photo BIO-OIL, AIST, 2)raduate School of Engineering, Osaka University, 3)Screen holdings Co., Ltd., 4)IST, CMB, 5)School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 131-131, 2022.
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P-51. Development of a new test method using Japanese quail embryos to detect chemical-induced abnormalities in sexual differentiation
Takaharu Kawashima1), Win Shwe Tin Tin1), Asato Kuroiwa2), Shusei Mizushima2), Shinji Tsukahara3)
1)Health and Environmental Risk Division, National Institute for Environmental Studies, 2)Department of Biological Sciences, Faculty of Science, Hokkaido University, Division of Life Science, 3)Division of Life Science, Graduate School of Science and Engineering, Saitama University
Alternatives to Animal Testing and Experimentation 27 (suppl) 131-131, 2022.
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P-52. Importance of glial cells in assessing neurotoxicity : a basic study using mouse-derived strain cells
Masahiro Ohgidani, Eriko Furube, Shigetaka Yoshida
Asahikawa Medical University
Alternatives to Animal Testing and Experimentation 27 (suppl) 132-132, 2022.
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P-53. Real-time luminescence monitoring of signal disruption to evaluate the developmental toxicity for pharmaceuticals
Yusuke Okubo1), Kashu Mizota1)2), Satoshi Kitajima1), Yoko Hirabayashi3), Yoshihiro Nakajima4), Junji Fukuda4)
1)Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Sciences, 2)Faculty of Engineering, Yokohama National University, 3)Biological Safety Research Center, National Institute of Health Sciences, 4)Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 27 (suppl) 132-132, 2022.
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P-54. Evaluation of the immunotoxicity of nanoparticles of cerium dioxide and zinc oxide using THP-1 cells
Maki Yamashiro1), Takao Ashikaga2), Akiko Ohno2), Kazutoshi Iijima3)
1)Graduate School of Engineering Science, Yokohama National University, 2)Division of Risk Assessment, Center for Biological Safety & Research, National Institute of Health Sciences, 3)Faculty of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 27 (suppl) 133-133, 2022.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-55. Development of a supercooling preservation method of adherent cultured cells
Maaya Hikichi
Graduate School of Science and Engineering, University of Gunma
Alternatives to Animal Testing and Experimentation 27 (suppl) 133-133, 2022.
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P-56. Co-culture of renal tubular cells and endothelial cells and the effect of fbroblasts for the development of a three-dimensional tubular model
Miyuu Yamazaki
Graduate School of Science and Engineering, University of Gunma
Alternatives to Animal Testing and Experimentation 27 (suppl) 134-134, 2022.
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P-57. In vitro evaluation of drug-induced kidney injury by three-dimensional culture of proximal tubular epithelial cells
Hiroshi Arakawa1), Daichi Higuchi1), Etsushi Takahashi2), Shiho Nedachi1), Masayuki Kondo2), Yoichi Jimbo2), Ikumi Tama1)
1)Faculty of Pharmaceutical Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, 2)R&D Department, Industrial Division, Nikkiso Co., Ltd.
Alternatives to Animal Testing and Experimentation 27 (suppl) 134-134, 2022.
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P-58. Development of 3D-culture model using human renal proximal tubule epithelial cells and characterization of its transporter function
Etsushi Takahashi1), Fumihiko Kitagawa1), Masayuki Kondo1), Asami Saito2), Gaku Morinaga2), Masahito Takatani2), Naoki Ishiguro2), Hiroshi Arakawa3), Daichi Higuchi3), Shiho Nedachi3), Ikumi Tamai3), Yoichi Jimb1)
1)R&D Department, Industrial Division, Nikkiso Co. Ltd, 2)Pharmacokinetics and Non-clinical Safety Department, Nippon Boehringer Ingelheim Co. Ltd, 3)Faculty of Pharmaceutical Sciences, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University
Alternatives to Animal Testing and Experimentation 27 (suppl) 135-135, 2022.
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P-59. Development of evaluation system for effects on the central nervous system of food ingredients using human iPS cell-derived neural progenitor cells
Yuki Hanafusa1), Fumiyuki Hattori2)
1)Group Quality Assurance Division, Suntory Holdings Limited, 2)The Graduate School of Medicine, Kansai Medical University
Alternatives to Animal Testing and Experimentation 27 (suppl) 135-135, 2022.
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P-60. Development of a novel MAT test using immortalized myeloid cells (aMylc) derived from human PBMCs
Toshie Kusunoki, Ami Murakami, Yuka Yoshimura, Yua Yoshimura, Sachiko Maeno, Jun Shimizu, Kazuo Miyazaki
MiCAN Technologies Inc.
Alternatives to Animal Testing and Experimentation 27 (suppl) 136-136, 2022.
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P-61. Electrophysiological drug assessment of human iPSC-derived sensory neurons using Multi-Electrode Array (MEA) and their potential as an alternative model for dorsal root ganglia
Minami Hiranuma, Yuichi Okuda, Tomohisa Watanabe
ReproCELL. Inc
Alternatives to Animal Testing and Experimentation 27 (suppl) 136-136, 2022.
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P-62. Investigation of non-invasive evaluation by toxicity assay using spheroids
Asako Motomura1), Yoko Igarashi1), Hiroshi Suganuma1), Yoshihiko Watanabe2), Kazuya Matsushima2), Nobuhiko Kojima2)
1)Sumitomo Electric Industries, Ltd., 2)Yokohama City University
Alternatives to Animal Testing and Experimentation 27 (suppl) 137-137, 2022.
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P-63. An on-chip pump integrated multi-organ microphysiological system for drug development
Kenta Shinha1), Hiroko Nakamura1), Naoki Ishida2), Hiroshi Arakawa2), Masaki Nishikawa3), Yukio Kato2), Yasuyuki Sakai3), Hiroshi Kimura1)
1)Tokai University, 2)Kanazawa University, 3)The University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 137-137, 2022.
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P-64. Research contributing to the development of a bile excretion evaluation system using 3D culture scaffold, Cellbed by mimicking the in vivo bile excretion function from hepatocytes
Ryota Oyafuso1), Yuji Komizu1), Takuya Iwasa2), Kouhei Sasaki2), Rie Kojima2), Masaaki Kawabe2), Taku Matsushita1), Seiichi Ishida1)3)
1)Division of Applied Life Science, Graduate School of Engineering, Sojo University, 2)Central Research Laboratory, Japan Vilene Company, Ltd., 3)Division of Pharmacology, National Institute of Health Sciences.
Alternatives to Animal Testing and Experimentation 27 (suppl) 138-138, 2022.
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P-65. In-vitro electrophysiological evaluation of pancreatic β cells based on thin flm transistor microelectrode arrays
Dongchen Zhu1), Anne Claire Eiler4), Satoshi Ihida2), Yasuyuki Sakai1), Hiroshi Toshiyoshi2), Agnes Tixier Mita2), Kikuo Komori3)
1)Department of Chemical System Engineering, Graduate School of Engineering, University of Tokyo, 2)Institute of Industrial Science, The University of Tokyo, 3)Department of Biotechnology and Chemistry, Graduate School of System Engineering, Kindai University, 4)Department of Electrical Engineering and Information System, Graduate School of Engineering, University of Tokyo
Alternatives to Animal Testing and Experimentation 27 (suppl) 138-138, 2022.
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P-66. Improvement of similarity to blood vessels and infammatory response of HUVECs by spheroid culture
Daiki Tanaka, Sanshiro Hanada, Nobuhiko Kojima
School of Science, Yokohama City University
Alternatives to Animal Testing and Experimentation 27 (suppl) 139-139, 2022.
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P-67. Use of silkworm strains as alternative experimental animals for the evaluation of functions to improve metabolic syndrome
Ryuichiro Tanaka1), Ryouhei Mori1), Eisuke Miyazaki1), Sayaka Tanibuchi1), Kai Motoki1), Yutaka Banno2)
1)Faculty of Pharmaceutical Sciences, Setsunan University, 2)Faculty of Agriculture, Kyusyu University
Alternatives to Animal Testing and Experimentation 27 (suppl) 139-139, 2022.
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P-68. 3D tumor device with perfusable blood vessels
Nobuhito Mori1), Ryo Tsumura2), Yoshikatsu Koga3), Yasuyuki S. Kida1)3)
1)Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2)Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, 3)School of Integrative & Global Majors, University of Tsukuba
Alternatives to Animal Testing and Experimentation 27 (suppl) 140-140, 2022.
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P-69. Reproduction of drug resistance in human pancreatic cancer cells using three-dimensional culture carrier
Yuji Komizu1), Seiichiro Chitose1), Kouhei Hiyoshi1), Mayuko Kitajima1), Takuya Iwasa2), Kouhei Sasaki2), Rie Kojima2), Masaaki Kawabe2), Taku Matsushita1), Seiichi Ishida1)3)
1)Division of Applied Life Science, Graduate School of Engineering, Sojo University, 2)Central Research Laboratory, Japan Vilene Company, Ltd., 3)Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 140-140, 2022.
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P-70. Deactivation of hepatic stellate cells in three-dimensional culture for the culture technique for therapeutic drug development for non-alcoholic steatohepatitis (NASH)
Satoha Aihoshi1), Yukie Kuroda2), Shinichiro Horiuchi2), Hiroyoshi Sadohara1), Riko Jinno1), Yuji Komizu1), Taku Matsushita1), Seiichi Ishida1)2)
1)Division of Applied Life Science, Graduate School of Engineering, Sojo University, 2)Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 27 (suppl) 141-141, 2022.
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P-71. Toward the Development of Qualitative and Quantitative Analytical Devices for On-site Rapid Evaluation of Biomacromolecules in Cell-based Bioassays
Kikuo Komori1), Dongchen Zhu2), Ayano Takenouchi1), Yuma Hori1), Satoshi Ihida2), Yasuyuki Sakai2), Hiroshi Tioshiyoshi2), Hiroshi Kimura3), Agnes Tixier Mita2)
1)Kindai University, 2)The University of Tokyo, 3)Tokai University
Alternatives to Animal Testing and Experimentation 27 (suppl) 141-141, 2022.
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P-72. Development of an Integrated Aerobic Cell Culture System with a Glucose Sensor
Yuma Hori1), Hiroshi Kimura2), Kikuo Komori1)2)
1)Kindai University, 2)Tokai University
Alternatives to Animal Testing and Experimentation 27 (suppl) 142-142, 2022.
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P-73. Development of 2D and 3D Functional Platforms for Integrated Neuromuscular Junction Studies
Margaret Anne Craig, Ashley Barnes
Axol Bioscience
Alternatives to Animal Testing and Experimentation 27 (suppl) 142-142, 2022.
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P-74. Introduction of 3rd Asian Congress for Alternatives to Animal Experiments (ACAAE) organized by Korean Society for Alternatives to Animal Experiments (KSAAE)
Ki-Suk Kim1)2)
1)R&D Center for Advanced Pharmaceutical Evaluation, Korea Institute of Toxicology, 2)Editor-in-Chief, Korean Society for Alternatives to Animal Experiments (KSAAE)
Alternatives to Animal Testing and Experimentation 27 (suppl) 143-143, 2022.
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