アブストラクト
| Title | フルーツジュースとの薬物相互作用 |
|---|---|
| Subtitle | 特集 モニタリングから介入まで 自信をもって対応できる薬物相互作用 |
| Authors | 赤嶺由美子*1, 三浦昌朋*2 |
| Authors (kana) | |
| Organization | *1秋田大学医学部附属病院薬剤部, *2教授・薬剤部長 |
| Journal | 月刊薬事 |
| Volume | 61 |
| Number | 4 |
| Page | 601-606 |
| Year/Month | 2019 / 3 |
| Article | 報告 |
| Publisher | じほう |
| Abstract | [Points]●グレープフルーツジュースは小腸のCYP3A/P糖タンパク質(P-gp)を阻害し, 基質薬物の血中濃度上昇を引き起こす. ●グレープフルーツジュースによるCYP3A/P-gpの阻害はコップ1杯の量で引き起こされ, 24時間〜3日間阻害効果が持続するため, 相互作用は服薬時間をずらすことでは回避できず, 事前にグレープフルーツジュースの飲用を避けるよう説明が必要である. ●グレープフルーツジュースならびにアップルジュース, オレンジジュースは小腸のOATP2B1を阻害し, 基質薬物の血中濃度減少を引き起こす. ●フルーツジュースコップ1杯(250〜400mL)で十分にOATP2B1は阻害されるが, 約4時間あけることで阻害の影響がなくなり, 相互作用の影響を回避できると考えられる. |
| Practice | 薬学 |
| Keywords |
- 全文ダウンロード： 従量制、基本料金制の方共に803円(税込) です。
参考文献
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残りの19件を表示する
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