Journal of Pharmacological Sciences 103巻 suppl.1号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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PL1 My Odyssey to the Nobel Prize, and Beyond.

Arvid Carlsson
Sahlgrenska Academy, University of Goteborg
Journal of Pharmacological Sciences 103 (suppl.1) 2-2, 2007.

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SL1 New strategies for innovating the process of development of drugs and medical technologies--integrative celerity research--

Hiroo Imura
Foundation for Biomedical Research and Innovation, Center for Research and Development Strategy(CRDS), Japan Science and Technology Agency, Kyoto University
Journal of Pharmacological Sciences 103 (suppl.1) 4-4, 2007.

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SL2 Frontiers of Life Science uncovered by Molecular Motors, Kinesin Superfamily Proteins, KIFs

Nobutaka Hirokawa
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 4-4, 2007.

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SL3 G-protein-mediated signalling pathways in vascular physiology and pathology

Stefan Offermanns
Institute of Pharmacology, University of Heidelberg
Journal of Pharmacological Sciences 103 (suppl.1) 5-5, 2007.

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SL4 My Journey in Pharmacology, Prostanoid Receptors and Rho

Shuh Narumiya
Department of Pharmacology, Kyoto University Faculty of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 5-5, 2007.

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SL6 Ca2+ dynamics and intracellular signal transduction

Katsuhiko Mikoshiba1, 2
1Division of Molecular Neurobiology, Insitute of Medical Science, The University of Tokyo, 2Laboratory for Developmental Neurobiology, RIKRN Brain Science Institute
Journal of Pharmacological Sciences 103 (suppl.1) 6-6, 2007.

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SL7 Cognition and Antidepressants:beyond behavioural toxicity.

Ian Hindmarch
University of Surrey
Journal of Pharmacological Sciences 103 (suppl.1) 7-7, 2007.

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SL8 Toward the identification of novel genes possibly involved in learning and memory

Remi Quirion, Jonathan brouillette
Douglas Hospital Research Centre, Mcgill University
Journal of Pharmacological Sciences 103 (suppl.1) 7-7, 2007.

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SL9 Integrative mechanisms of synaptic transmission in the neural network

Shigetada Nakanishi
Osaka Bioscience Institute
Journal of Pharmacological Sciences 103 (suppl.1) 8-8, 2007.

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EL1 An Encouragement of Pharmacology and Toxicology-from Drug Discovery to Food Safety-

Taku Nagao
Food Safety Commission, Cabinet Office Government of Japan
Journal of Pharmacological Sciences 103 (suppl.1) 10-10, 2007.

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EL2 Misconduct and Conflict of Interest in Science

Hideaki Karaki
Science Council of Japan
Journal of Pharmacological Sciences 103 (suppl.1) 10-10, 2007.

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AL1 Study on the mechanism of neuropsychological abnormalities induced by drugs of abuse

Taku Nagai
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 12-12, 2007.

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AL2 Mechanisms of intractable neuropathic pain through ATP receptors

Makoto Tsuda
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University
Journal of Pharmacological Sciences 103 (suppl.1) 12-12, 2007.

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AL3 Roles of endogenous PACAP in the nervous system

Norihito Shintani
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
Journal of Pharmacological Sciences 103 (suppl.1) 13-13, 2007.

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S1A1-1 Signal transduction mechanism of β-blocker

Hitoshi Kurose
Dept.Pharmacol.Toxicol., Grad.Sch.Pharma.Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 16-16, 2007.

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S1A1-2 An update on the prevention and management of cardiovascular diseases

Takeshi Murakami
Sapporo Central Health Promotion Center
Journal of Pharmacological Sciences 103 (suppl.1) 16-16, 2007.

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S1A1-3 In vitro and in vivo analysis of receptors for lipid mediators

Takehiko Yokomizo1, 2
1Dep.Med.Biochem., Grad.Sch.Med.Sci., Kyushu Univ., 2CREST, JST
Journal of Pharmacological Sciences 103 (suppl.1) 16-16, 2007.

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S1A1-4 Pharmacogenetics of asthma treatment with GPCR agonists and antagonists

KOICHIRO ASANO
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 16-16, 2007.

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S1A1-5 Ligand identification and functional analysis for fatty acid receptors

Akira Hirasawa, Gozoh Tsujimoto
Dept.Genomic Drug Discovery Sci., Grad.Sch.Pharmaceu.Sci.Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 17-17, 2007.

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S1B1-1 Rho-kinase and Rho family GTPase signaling

Mutsuki Amano, Kozo Kaibuchi
Dept.Cell Pharmacol, Nagoya Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 17-17, 2007.

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S1B1-2 Structure of protein kinases:Rho-kinase and related AGC kinases

Toshio Hakoshima
Structural Biology Lab., NAIST ＆ CREST
Journal of Pharmacological Sciences 103 (suppl.1) 17-17, 2007.

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S1B1-3 Role of p38 MAP kinase in cell death induced by anti-cancer drugs

Hideyuki Saya, Shin-ichi Iida, Sampetrean Oltea
Dept.Tumor Genet.＆ Biol., Kumamoto Univ.Sch.Med.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 17-17, 2007.

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S1B1-4 Translational Research for the Development of Rho-kinase Inhibitors

Hiroaki Shimokawa
Cardiovascular Medicine, Tohoku Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 18-18, 2007.

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S1C1-1 Therapeutic strategies for Alzheimer's disease by manipulating brain protease activities

Nobuhisa Iwata, Takaomi C.Saido
Lab.for Proteolytic Neurosci., RIKEN BSI
Journal of Pharmacological Sciences 103 (suppl.1) 18-18, 2007.

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S1C1-2 Neurotoxicity of amyloid β proteins

Naoki Hattori, Kaori Kitagawa, Yasuhisa Nakayama, Li Yang, Zheng-Mei Xiong, Tiesong Li, Chiyoko Inagaki
Dept.Pharmacol., Kansai Medical Univ
Journal of Pharmacological Sciences 103 (suppl.1) 18-18, 2007.

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S1C1-3 In vivo imaging of amyloid plaques in the brain

Nobuyuki Okamura1, Yukitsuka Kudo2, Hiroyuki Arai3, Kazuhiko Yanai1
1Dept.Pharmacol., Tohoku Univ.Sch.Med., 2TUBERO, Tohoku Univ.,, 3Dept.Geriat.Gerontol., Tohoku Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 18-18, 2007.

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S1C1-4 The New Approach in Development of Anti-Alzheimers Disease Drugs via the Cholinergic Hypothesis and Amyloid Hypothesis

Hachiro Sugimoto
Department of Neuroscience for drug Discovery, Graduate School of Pharmaceutical Science Kyoto University
Journal of Pharmacological Sciences 103 (suppl.1) 19-19, 2007.

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S1C1-5 Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders

Kohji Fukunaga1, 2, Norifumi Shioda1, Motohiro Morioka3
1Dept.Pharmacol., Tohoku Univ.Grad.Sch.Pharm.Sci., 2Tohoku Univ.21st Century COE Program CRESCENDO, 3Dept.Neurosurgery Kumamoto Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 19-19, 2007.

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S1C1-6 Clinical aspects of Alzheimer's disease:Current status and issues to have to be solved.

Akira Homma
Dementia Intervention Research Group, Tokyo Metropolitan Institute of Gerontology
Journal of Pharmacological Sciences 103 (suppl.1) 19-19, 2007.

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S1C1-7 Treatment of Alzheimer Disease-Status Quo and Future Considerations

Shun Shimohama
Dept.Neural., Sapporo Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 19-19, 2007.

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S1D1-1 Fall of the Cholesterol Hypothesis and the Importance of Selecting Polyunsaturated Fatty Acids

Harumi Okuyama
Kinjo Gakuin University College of Pharmacy
Journal of Pharmacological Sciences 103 (suppl.1) 20-20, 2007.

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S1D1-2 Protective and ameliorative effects of n-3 polyunsaturated fatty acid on dementia

Michio Hashimoto1, Masanori Katakura1, Yoko Tanabe1, Shahdat Hossain1, Shuji Gamoh1, Teruo Miyazawa2, Hiroyuki Arai3, Osamu Shido1
1Dept.Environ.Physiol., Shimane Univ.Sch.Med., 2Dept.Food Biodynam.Chem.Lab., Grad.Sch.Agr, Sci., Tohoku Univ., 3Dept.Geriat.Geront., Tohoku Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 20-20, 2007.

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S1D1-3 Diabetes mellitus and fatty acid:Basic study

Mikio Ito, Ryoji Kojima
Lab.Anal.Pharmacol., Fac.Pharm., Meijo Univ
Journal of Pharmacological Sciences 103 (suppl.1) 20-20, 2007.

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S1D1-4 Randomized controlled dietary intervention in patients polypectomized for tumors of the colorectum

Shinkan Tokudome1, Kiyonori Kuriki2, Yoshifumi Yokoyama3, Makoto Sasaki4, Takashi Joh4, Takeshi Kamiya4, Kumiko Ogawa5, Tomoyuki Shirai5, Harumi Okuyama6
1Dept.Health Promot.Prev.Med., Nagoya City Univ.Grad.Sch.Med., 2Aichi Cancer Center, 3Higashi Municipal Hospital of Nagoya, 4Dept.Int.Med., Naogya City Univ.Grad.Sch.Sci., 5Dept.Pathol., Nagoya City Univ.Grad.Sch.Med.Sci., 6Kinjo-gakuin Univ
Journal of Pharmacological Sciences 103 (suppl.1) 20-20, 2007.

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S1D1-5 Transcriptional regulation of fatty acid synthesis and insulin resistance

Hitoshi Shimano
Department of Internal Medicine(Endocrinology and Metabolism), Graduate School of Comprehensive Human Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba
Journal of Pharmacological Sciences 103 (suppl.1) 21-21, 2007.

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S1D1-6 Reducing effect of EPA on coronary events(Results of the JELIS Trial)

Hiroshige Itakura
Dept.Food Sci.Ibaraki Christian Univ
Journal of Pharmacological Sciences 103 (suppl.1) 21-21, 2007.

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S1A2-1 Colorectal cancer as a metabolic syndrome~From carcinogenesis to medical treatment~

Hirokazu Takahashi, Hitoshi Nakagama
National Cancer Center, Biochemistry Division
Journal of Pharmacological Sciences 103 (suppl.1) 21-21, 2007.

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S1A2-2 Endocrine disruptors stimulate lipid accumulation in target cells and organs related to metabolic syndromes.

Koichiro Wada, Yoshinori Kamisaki
Dept.Pharmacol., Grad.Sch.Dent., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 21-21, 2007.

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S1A2-3 A new in vitro model of hepatitis C virion production(The possibility to develop vaccines and drugs for HCV)

Satoru Saito, Theo Heller, T.Jake Liang
NIH, NIDDK, Liver Disease Section
Journal of Pharmacological Sciences 103 (suppl.1) 22-22, 2007.

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S1A2-4 Cell culture system for the screening of anti-HCV reagents:combination therapy of statins with IFN

Masanori Ikeda
Dept.Mol.Biol.Okayama Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 22-22, 2007.

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S1A2-5 Insight into the mecanisms responsible for the progression of nonalcoholic steatohepatitis(NASH)by using DNA microarray and therapeutic strategies for NASH by treating with pioglitazone

Masato Yoneda1, Koji Fujita1, Atsushi Nakajima1, Koichiro Wada2
1Division of Gastroenterology, Yokohama City Univ.Graduate School of Medicine, 2Dept.Pharmacol., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 22-22, 2007.

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S1B2-1 The study of associations among the biological rhythm, sleep, mood, and autonomic functions-from the viewpoint of clinical psychiatry-

Tsuyoshi Kitajima, Nakao Iwata
Department of Psychiatry, Fujita Health University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 22-22, 2007.

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S1B2-2 Role of brain arachidonic acid cascade on the central activation of sympatho-adrenomedullary outflow in rats

Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Kunihiko Yokotani
Dept.Pharmacology, Grad.Sch.of Medicine, Kochi Univ
Journal of Pharmacological Sciences 103 (suppl.1) 23-23, 2007.

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S1B2-3 Critical Role of Nitric Oxide Synthase System in the Maintenance of Body Homeostasis:Lessons from Mice Lacking All Nitric Oxide Synthase Isoforms

Masato Tsutsui1, Hiroaki Shimokawa2, Susumu Ueno1, Yumiko Toyohira1, Nobuyuki Yanagihara1
1Dept.Pharmacol., Sch.Med., Univ.Occup.＆ Environ.Health, 2Dept.Cardiovasc.Med., Tohoku Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 23-23, 2007.

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S1B2-4 V1a Vasopressin receptors maintain normal blood pressure by regulating circulating blood volume and baroreflex sensitivity

Taka-aki Koshimizu, Gozoh Tsujimoto
Grad.Sch.Pharmaceut.Sci., Univ.Kyoto
Journal of Pharmacological Sciences 103 (suppl.1) 23-23, 2007.

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S1B2-5 Discovery of a novel hormone (HP complex)that controls hibernation in the brain

Noriaki Kondo
Mitsubishi Kagaku Inst.of Life Sci
Journal of Pharmacological Sciences 103 (suppl.1) 23-23, 2007.

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S1C2-1 Mechanisms of cognitive deficits in schizophrenic animal models and efficacy of antipsychotics

Yukihiro Noda1, 2, Toshitaka Nabeshima2
1Divi.Clin.Sci.Neuropsychopharmacol., Fac.Pharm., Meijo Univ., 2Dept.Neuropsychopharmacol.Hosp.Pharm., Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 24-24, 2007.

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S1C2-2 PACAP and schizophrenia:from experimental to clinical

Hitoshi Hashimoto1, 2, Ryota Hashimoto2, 3, Norihito Shintani1, Toshio Matsuda2, 4, Yukio Ago4, Michiya Kakuda2, Akemichi Baba1
1Lab.Mol.Neuropharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 2Center for Child Mental Dev., Grad.Sch.Med, Osaka Univ., 3Depart.Psychiatry, Grad.Sch.Med, Osaka Univ., 4Lab.Medicinal Pharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 24-24, 2007.

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S1C2-3 Translational neuroscience of schizophrenia:neurodevelopment, glutamate and dopamine

Akira Sawa
Dept.Psychiatry, Johns Hopkins Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 24-24, 2007.

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S1C2-4 Treating schizophrenia by domain:focus on cognition

Carol A.Tamminga, Mujeeb U.Shad
University of Texas Southwestern Medical Center
Journal of Pharmacological Sciences 103 (suppl.1) 24-24, 2007.

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S2A1-1 A therapeutic target for microvascular complications in diabetes:endothelium-derived hyperpolarizing factor

Katsuo Kamata, Takayuki Matsumoto, Tsuneo Kobayashi
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 103 (suppl.1) 25-25, 2007.

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S2A1-2 Endothelial dysfunction and insulin resistance

Takashi Kasowaki, Tetsuya Kubota, Naoto Kubota, Ryozo Nagai
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 25-25, 2007.

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S2A1-3 Life style-related diseases and atherosclerosis

Nobuhiro Yamada
Metabolism.Endocrinology, Univ.Tsukuba
Journal of Pharmacological Sciences 103 (suppl.1) 25-25, 2007.

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S2A1-4 The regulation of endothelial function is important during the antiplatelet therapy in ischemia/reperfusion injury.

Toshiaki Iba, Masaki Fukunaga, Hidenori Tsumura
Department of Emergency Medicine, Juntendo University
Journal of Pharmacological Sciences 103 (suppl.1) 25-25, 2007.

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S2A1-5 Significance of vascular endothelial cell dysfunctions in septic shock

Naoyuki Matsuda, Yuichi Hattori
Dept.of Mol.＆ Med.Pharmacol.Graduate Sch.of Med.＆ Pharm.Sci., Univ.of Toyama
Journal of Pharmacological Sciences 103 (suppl.1) 26-26, 2007.

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S2B1-1 Treatment and management of osteoporosis:what do we know and what do we need?

Atsushi Suzuki
Div.Endocrinol., Fujita Health Univ
Journal of Pharmacological Sciences 103 (suppl.1) 26-26, 2007.

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S2B1-2 Glutamatergic signaling system in bone

Yukio Yoneda, Eiichi Hinoi, Takeshi Takarada
Lab.Mol.Pharmacol.Kanazawa Univ.Grad.Sch.Nat.Sci.Tech
Journal of Pharmacological Sciences 103 (suppl.1) 26-26, 2007.

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S2B1-3 The physiological function of sympathetic nervous system in modulating bone metabolism

Akifumi Togari, Michitsugu Arai
Dept.Pharmarol., Aichi-Gakuin Univ.Sch.Dent
Journal of Pharmacological Sciences 103 (suppl.1) 26-26, 2007.

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S2B1-4 Reveromycin A, a novel agent for osteoporosis inhibits bone resorption by inducing apoptosis specifically in osteoclasts

Je Tae Woo
Dept.Biol.Chem., Chubu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 27-27, 2007.

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S2B1-5 A novel bisphosphonate for the treatment of periodontitis

Hisashi Shinoda1, Sadaaki Takeyama2, Keiko Suzuki3, Shinobu Murakami1, Syoji Yamada3
1Dept.Applied Dent.Pharmacol., Tohoku Univ.Grad.Sch.Dent., 2Div.Dent.Pharmacol., Dept.Oral Biol., Tohoku Univ.Grad.Sch.Dent., 3Dept.Pharmacol., Sch.Dent., Showa Univ
Journal of Pharmacological Sciences 103 (suppl.1) 27-27, 2007.

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S2C1-1 Pharmacogenomics network in the development of treatment for metabolic syndrome

Toshimasa Yamauchi, Takashi Kadowaki
Dept.of Metabolic Diseases, Graduate Sch.of Med, Univ.of Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 27-27, 2007.

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S2C1-2 A New approach of Drug Discovery for Lipid metabolism-improvement using Genomic Network-Analysis

Yoshiyuki Takahara1, Tetsuya Adachi2, Tomoko Kobayashi1, Kazuhisa Takemoto1, Kozo Kawahara3, Ken Osaki3, Gozoh Tsujimoto2
1PharmaFrontier Co., Ltd, 2GDDS, Pharm, Kyoto U., 3World Fusion Co., Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 27-27, 2007.

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S2C1-3 Pharmacogenomic Network Analysis of Cardiovascular Medicines

Toshio Tanaka1, 2, Yasuhito Shimada1, 2, Liqing Zang1, 2, Minoru Hirano1, 2, Takehiko Oka1
1Dept.Pharmacogenomics, Mie Univ.Graduate Sch.Med., 2Dept.Bioinfo.Mie Univ.Life Science Res.Cent
Journal of Pharmacological Sciences 103 (suppl.1) 28-28, 2007.

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S2C1-4 Molecular network analysis in pleiotropic effects of statin

Masayuki Shiota, Hiromi Kusakabe, Yuko Hikita, Takafumi Nakao, Yasukatsu Izumi, Hiroshi Iwao
Dept.Pharmacol., Osaka City Univ.Med.Sch
Journal of Pharmacological Sciences 103 (suppl.1) 28-28, 2007.

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S2D1-1 Pathophysiological significance of non-neuronal acetylcholine:an overview

Koichiro Kawashima
Dept.Pharmacol., Kyoritsu Col.Pharm
Journal of Pharmacological Sciences 103 (suppl.1) 28-28, 2007.

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S2D1-2 Biological and clinical significance of non-neuronal acetylcholine and novel peptide ligands of epithelial nicotinic acetylcholine receptors(nAChRs)

Sergei A Grando
Dept.Dermatol., Univ.Cal.Davis
Journal of Pharmacological Sciences 103 (suppl.1) 28-28, 2007.

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S2D1-3 Expression of non-neuronal acetylcholine(ACh)in small cell lung carcinoma(SCLC)and its involvement in growth regulation

Eliot R Spindel
Div.Neurosci., Oregon Natl.Primate Res.Ctr., Oregon Health Sci.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 29-29, 2007.

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S2D1-4 Expression of non-neuronal acetylcholine in lymphocytes and its clinical significance in immunotherapy.

Takeshi Fujii1, Yuki Takada-Takatori1, Koichiro Kawashima2
1Dept.Pharmacol., Fac Pharmaceutical Sci., Doshisha Women's Coll., 2Dept.Pharmacol., Kyoritsu Coll.Pharmacy
Journal of Pharmacological Sciences 103 (suppl.1) 29-29, 2007.

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S2D1-5 Expression of Non-neuronal Acetylcholine(ACh)in Urothelium and Its Clinical Significance

Masaki Yoshida, Akito Inadome, Koichi Masunaga, Shoichi Ueda
Department of Urology, Graduate School of Medical Sciences, Kumamoto University
Journal of Pharmacological Sciences 103 (suppl.1) 29-29, 2007.

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S2A2-1 Discovery and target identification of compounds that induce translation of pre-mRNA containing introns

Minoru Yoshida1, 2
1DRI, RIKEN, Wako, 2CREST, JST
Journal of Pharmacological Sciences 103 (suppl.1) 29-29, 2007.

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S2A2-2 Approarch toward De Novo Biosynthesis of Useful Bioactive Natural Products

Hideaki Oikawa
Dept.of Chem., Hokkaido Univ., Grad.Sch.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 30-30, 2007.

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S2A2-3 Identification of molecular targets by Cancer Cell Informatics

Takao Yamori
Div.Mol.Pharmacol., Cancer Chemother.Ctr., Jpn.Found.Cancer Res
Journal of Pharmacological Sciences 103 (suppl.1) 30-30, 2007.

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S2A2-4 Identification of bioactive small organic molecules by using cellular differentiation as a sensitive indicator

Yoshinori Kawazoe, Motonari Uesugi
Chemical Biology, Ins.for Chemical Res.Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 30-30, 2007.

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S2A2-5 Selective Inhibitors of Necrotic Cell Death Induced by Oxidative Stress

Mikiko Sodeoka
RIKEN
Journal of Pharmacological Sciences 103 (suppl.1) 30-30, 2007.

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S2A2-6 Visualization and manipulation of mRNA alternative splicing

Masatoshi Hagiwara
Lab.Gene Expression, Sch.Biomed.Sci., Tokyo Med.＆ Dent.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 31-31, 2007.

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S2B2-1 Glial P2 receptors are attractive targets for drug discovery

Schuichi Koizumi1, 3, Shinozaki Yoichi1, Kaoru Nasu-Tada1, Kazuhide Inoue2
1Div.Pharmacol.Natl.Inst.Hlth.Sci., 2Dept.Mol.Sytem Pharmacol., Grad.Sch.Pharmaceut.Sci., Kyushu Univ., 3Dept.Pharmacol., Univ.of Yamanashi
Journal of Pharmacological Sciences 103 (suppl.1) 31-31, 2007.

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S2B2-2 Novel effects of a drop-out CNS drug on astrocyte:As a clue for developing new drug for CNS

Yoshihisa Kudo
Tokyo Univ.of Pharm ＆ Life Sci., Sch.Life Sci
Journal of Pharmacological Sciences 103 (suppl.1) 31-31, 2007.

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S2B2-3 Glial GPCR:pathological role and drug development

Keiji Wada1, 2
1National Institute of Neuroscience, NCNP, 2CREST, JST
Journal of Pharmacological Sciences 103 (suppl.1) 31-31, 2007.

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S2B2-4 Role of glia on glutamate hypothesis of schizophrenia and new therapeutic approach

Kenji Hashimoto
Div.Clin.Neurosci., Chiba Univ.Ctr Forensic Ment.Health
Journal of Pharmacological Sciences 103 (suppl.1) 32-32, 2007.

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S2C2-1 Therapeutic approach to learning and memory impairment using neuropeptides

Masayuki Hiramatsu1, 2
1Dept.Chem.Pharmacol., Fac.Pharm., Meijo Univ., 2Grad.Sch.Environ.and Human Sci., Meijo Univ
Journal of Pharmacological Sciences 103 (suppl.1) 32-32, 2007.

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S2C2-2 Neuroprotection by sigma-1 receptor ligands in Alzheimer's disease

Tangui Maurice1, 2, 3, Johann Meunier1, 2, 3
1INSERM U.710, 2EPHE, 3University of Montpellier II
Journal of Pharmacological Sciences 103 (suppl.1) 32-32, 2007.

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S2C2-3 Adult neurogenesis is dynamically and functionally associated with Alzheimer's disease-like neurodegeneration in the mouse

Ya-Ping Tang1, Qian Chen1, Akira Nakajima1, Se Hoon Choi2, Xiaoli Xiong1, Sangram S.Sisodia2
1Dept.Psychiat., Univ.of Chicago, 2Dept.Neurobiol., Pharmacol., and Physiol., Univ.of Chicago
Journal of Pharmacological Sciences 103 (suppl.1) 32-32, 2007.

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S2C2-4 Concept of New Therapeutic Drugs for Neurodegenerative disease from Clinical Aspects

Hidetoshi Endo
Dept.Comprehen.Geriat.Med
Journal of Pharmacological Sciences 103 (suppl.1) 33-33, 2007.

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S2C2-5 Role of dopamine D1 receptor/ERK1/2 signal in protein synthesis-dependent long-term recognition memory

Taku Nagai1, 2, Hiyoruki Kamei1, 3, Hiroyuki Mizoguchi1, Noritaka Nakamichi1, Toshitaka Nabeshima2, Makiko Suzuki2, Kazuhiro Takuma1, Kiyofumi Yamada1
1Lab.Neuropsychopharmacol., Grad.Sch.Natl.Sci.Tech., Kanazawa Univ., 2Dept.Neuropsychopharmacl.＆ Hosp.Pharm., Nagoya Univ.Grad.Sch.Med., 3Lab.Clin.Pharm., Fac.Pharm., Meijo Univ
Journal of Pharmacological Sciences 103 (suppl.1) 33-33, 2007.

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S2C2-6 Modulation of synaptic plasticity in the hippocampus by drugs, physiological substances and activities of the amygdala, and possible targets for drug development.

Norio Matsuki
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 33-33, 2007.

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S2D2-1 Current Perspective of "Mibyou" Medicine

Yoshihiro Fukuo
Hakujikai Institute of Gerontology
Journal of Pharmacological Sciences 103 (suppl.1) 33-33, 2007.

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S2D2-2 Regulation of allergic responses by Kampo medicines

Naoki Inagaki, Xiu Kun Gao, Hiroyuki Tanaka, Hiroichi Nagai
Dept.Pharmacol., Gifu Pharm.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 34-34, 2007.

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S2D2-3 Effects of polished and pre-germinated brown rice on the brain function in mice

Takayoshi Mamiya1, Mitsuo Kise2, Keiko Morikawa2, Hiromichi Aoto2, Makoto Ukai1
1Dept.Chem Pharmacol., Fac.Pharm., Meijo Univ., 2Applied Food Processing Group, FANCL Res.Inst, FANCL Corporation
Journal of Pharmacological Sciences 103 (suppl.1) 34-34, 2007.

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S2D2-4 Novel functions of vitamins and those possible application for the prevention of metabolic syndrome.

Michio Komai, Hitoshi Shirakawa
Lab.Nutrition, Grad.Sch.Agr.Sci., Tohoku University
Journal of Pharmacological Sciences 103 (suppl.1) 34-34, 2007.

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S2D2-5 Clinical Application and Precaution of Dietary Supplement

Nobutaka Suzuki
Dept.CAM., Kanazawa Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 34-34, 2007.

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S2A3-1 Microsomal prostaglandin E synthase-1:a critical factor of ischemic injury and a possible therapeutic target for stroke

Yuri Ikeda-Matsuo
Lab.Pharmacol., Sch.Pharmac.Sci., Kitasato Univ
Journal of Pharmacological Sciences 103 (suppl.1) 35-35, 2007.

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S2A3-2 Establishment of a new reperfusion stroke model and emerging strategies for the treatment of reperfusion injury

Hiroshi Yao
Center for Behavioral and Emotional Disorders, National Hospital Organization Hizen Psychiaric Center
Journal of Pharmacological Sciences 103 (suppl.1) 35-35, 2007.

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S2A3-3 Thrombin-MAP kinase signaling pathways in hemorrhagic stroke

Hiroshi Katsuki
Dept.Pharmacol., Grad.Sch.Pharm. Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 35-35, 2007.

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S2A3-4 Application of animal PET for imaging of ischemic neuronal damage

Hideo Tsukada
Cent.Res.Lab, Hamamatsu Photonics
Journal of Pharmacological Sciences 103 (suppl.1) 35-35, 2007.

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S2A3-5 Ischemic brain injury as astrogliopathy:a new therapeutic strategy targeting astrocytes

Shinichi Takahashi
Department of Neurology, Keio University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 36-36, 2007.

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S2B3-1 Pleiotropic effects of AT1 receptor blocker and translational research for treatment of cardiovascular diseases

Shokei Kim-Mitsuyama
Department of Pharmacology and Molecular Therapeutics Kumamoto University Graduate School of Medical Sciences
Journal of Pharmacological Sciences 103 (suppl.1) 36-36, 2007.

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S2B3-2 Application of Ang II suppressants based on the diversity of Ang II roots

Mizuo MIYAZAKI
Department of Pharmacology, Osaka Medical College
Journal of Pharmacological Sciences 103 (suppl.1) 36-36, 2007.

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S2B3-3 Clinical trials of ACE inhibitors and angiotensin receptor blockers for hypertension, heart failure and diabetic nephropathy in Japan:Focus on dose-finding and adverse events

Shigeru Kageyama
Division of Clin Pharmacol and Ther, Jikei University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 36-36, 2007.

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S2B3-4 Japanese large-scale clinical trials on the renin-angiotensin inhibitors.

Jitsuo Higaki
Dept.Integrated Med.＆ Informatics, Ehime Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 37-37, 2007.

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S2B3-5 Clinical pharmacological studies on renin-angiotensin system in man:Between basic life science and clinical trial

Shinichiro Ueda
Department of Clinical Pharmacology ＆ Therapeutics, University of the Ryukyus School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 37-37, 2007.

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S2C3-1 Neuroimaging Study for methamphetamine-induced neurotoxicity

Iyo Masaomi1, Hashimoto Kenji2
1Dept.Psychiatry, Chiba Univ Graduate Sch Med, 2Center for Forensic Mental Health
Journal of Pharmacological Sciences 103 (suppl.1) 37-37, 2007.

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S2C3-2 Molecular and neural mechanisms of neuropsychotoxicity induced by drugs of abuse

Takayuki Nakagawa, Yosuke Yamauchi, Yuichi Suzuki, Megumi Higuchi, Shuji Kaneko
Dept.Mol.Pharmacol., Grad.Sch.Pharmaceu.Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 37-37, 2007.

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S2C3-3 Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9 deficient mice

Hiroyuki Mizoguchi1, 2, Kiyofumi Yamada1, 2, Minae Niwa1, Akihiro Mouri1, Tomoko Mizuno1, Yukihiro Noda1, 4, Atsumi Nitta1, Shigeyoshi Itohara5, Yoshiko Banno3, Toshitaka Nabeshima1
1Dept.Neuropsychopharmacol., Hosp.Pham., Nagoya Univ.Grad.Sch.Med., 2Lab.Neuropsychopharmacol, Grad.Sch.Natu.Sci.Technol., Kanazawa Univ., 3Dept.Cell Signal, , Gifu Univ.Grad.Sch.Of Med., 4Div.Clinical.Sci.＆ Neuropsychopharm in Clinial Pharm.Pract., Manage.Res., Facul.Pharm., Meijo Univ., 5Lab.Behav.Genet., RIKEN BSI
Journal of Pharmacological Sciences 103 (suppl.1) 38-38, 2007.

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S2C3-4 Effects of serotonin receptor ligands on methamphetamine-and cocaine-induced behavioral sensitization in mice

Yukio Ago1, Shigeo Nakamura1, Akemichi Baba2, Toshio Matsuda1, 3
1Lab.Medicinal Pharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 2Lab.Mol.Neuropharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 3Center for Child Mental Dev., Grad.Sch.Med., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 38-38, 2007.

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S2C3-5 Role of glutathione peroxidase in the neurotoxicity and dependence induced by methamphetamine

Hyoung-Chun Kim1, Duong Xuan Chu1, Eun-Joo Shin1, Jong Seok Chae1, Toshitaka Nabeshima2
1Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, 2Dept of Neuropsychopharmacol Hospital Pharm, Nagoya Univ Grad Sch Med
Journal of Pharmacological Sciences 103 (suppl.1) 38-38, 2007.

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S2C3-6 ROLE OF NITRIC OXIDE AND PEROXYNITRITE IN METHAMPHETAMINE-INDUCED DOPAMINERGIC NEUROTOXICITY

Syed F Ali1, Syed Imam1, Yossef Itzhak2
1Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, 2Department of Psychiatry and Behavioral Sciences, Univesity of Miami School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 38-38, 2007.

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S2D3-1 Structure, function and regulated expression of the neurotransmitter transporters

Shigeo Kitayama1, Chiharu Sogawa1, Toshihiro Dohi2
1Dept.Dent.Pharmacol., Okayama Univ.Grad.Sch.Med.Dent.Pharm.Sci., 2Dept.Dent.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 39-39, 2007.

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S2D3-2 Monoamine transporter as a molecular target for drug abuse

Ichiro Sora1, 2, Hideko Yamamoto2, Kazutaka Ikeda2
1Dept.Biol Psychiat., Tohoku Univ.Grad.Sch.Med., 2Mol.Psychiat.Tokyo Instit.Psychiat
Journal of Pharmacological Sciences 103 (suppl.1) 39-39, 2007.

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S2D3-3 glutamate transporter and brain development

Kohichi Tanaka
Dept.Mol.Neurosci., Tokyo Medical ＆ Dental Univ.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 39-39, 2007.

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S2D3-4 Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice

Katsuya Morita, Naoyo Motoyama, Tomoya Kitayama, Norimitsu Morioka, Toshihiro Dohi
Dept.Dent.Pharmacol., Hiroshima Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 39-39, 2007.

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S2D3-5 Pathophysiology and Treatment of Depression Through PET imaging of Serotonin Transporter

Tetsuya Suhara
Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences
Journal of Pharmacological Sciences 103 (suppl.1) 40-40, 2007.

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S3A1-1 Pathophysiology of the lower urinary tract dysfunction.

Osamu Yokoyama, Keiko Nagase, Hironobu Akino
Div.Urol., Univ.Fukui Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 40-40, 2007.

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S3A1-2 α1-Adrenoceptor in the lower urinary tract.

Shigeru Morishima1, Takashi Tanaka1, Hatsumi Yamamoto1, Fumiko Suzuki1, Hironobu Akino2, Osamu Yokoyama2, Simpson Paul C.3, 4, Ikunobu Muramatsu1
1Div.Pharmacol., Univ.Fukui Sch.Med., 2Div.Urol., Univ.Fukui Sch.Med., 3Cardiovascular Division and Research Service, Veterans Affairs Medical Center, 4Cardiovascular Institute and Department of Medicine, University of California
Journal of Pharmacological Sciences 103 (suppl.1) 40-40, 2007.

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S3A1-3 The usefulness of a selective α 1A-blocker silodosin(URIEF(R))as a therapeutic agent for dysuria

Satoshi Tatemichi, Kumi Kobayashi, Mamoru Kobayashi, Yoshinobu Yamazaki
Pharmacology Research Laboratory, R＆D, Development Research Department, R＆D, Kissei Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 40-40, 2007.

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S3A1-4 Muscarinic receptor binding characteristics of novel anticholinergic agents directed toward the therapy of overactive bladder

Shizuo Yamada, Tomomi Fujino
Dept.Pharmacokinet.and Pharmacodyn., Sch.of Pharm.Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 103 (suppl.1) 41-41, 2007.

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S3A1-5 Basic and clinical studies of solifenacin succinate(Vesicare(R)), a bladder selective muscarinic receptor antagonist

Masanori Suzuki, Akiyoshi Ohtake, Shuichi Sato, Ken Ikeda
Pharmacol.Res.Labs., Drug Dis.Res., Astellas Pharma Inc
Journal of Pharmacological Sciences 103 (suppl.1) 41-41, 2007.

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S3B1-1 Molecular basis for the inhibition of anticancer agents-induced apoptosis by thymidine phosphorylase

Ryuji Ikeda
Dept.Clin.Pharm., Kagoshima Univ.Hosp
Journal of Pharmacological Sciences 103 (suppl.1) 41-41, 2007.

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S3B1-2 Circadian biological rhythms and chronopharmacotherapy of anti-cancer drugs

Satoru Koyanagi
Pharmaceutics, Div.Clin.Pharmacy, Dept.Medico-Pharm.Sci., Fact.Pharm Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 41-41, 2007.

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S3B1-3 Anticancer drugs developed in Japan;integral to the treatment of colorectal cancer

Takashi Tsuruo
Japanese Foundation For Cancer Research, Cancer Chemotherapy Center
Journal of Pharmacological Sciences 103 (suppl.1) 42-42, 2007.

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S3B1-4 Standard chemotherapy of colorectal cancer

deGramont Aimery
Hopital Saint-Antoine
Journal of Pharmacological Sciences 103 (suppl.1) 42-42, 2007.

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S3C1-1 Biochemical approach towards evaluation of treatment of neuropathc pain

Seiji Ito1, 2, 3, Jingshang Lu1, Tayo Katano1, Toshiaki Minami2, Yoshihiro Urade3
1Dept.Med.Chem., Kansai Med.Univ., 2Dept.Anesth., Osaka Med.Coll., 3Dept.Mol.Behav.Mol., Osaka Biosci.Inst
Journal of Pharmacological Sciences 103 (suppl.1) 42-42, 2007.

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S3C1-2 Novel mechanisms of antidepressants for neuropathic pain

Kazuhide Inoue
Dept.Mol.System Pharmacol., Grad.Sch.Pharmac.Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 42-42, 2007.

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S3C1-3 Alleviation of neuropathic pain by steroid hormone receptor antagonists

Tsutomu Tanabe, Daisuke Kondo, Ichiro Takasaki, Ritsuko Yabe, Takashi Kurihara, Hironao Saegusa, Shuqin Zong
Dept.Pharmacol.and Neurobiol., Grad.Sch.Med., Tokyo Med.and Dent.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 43-43, 2007.

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S3C1-4 The challenge of neuropathic pain:targeted drug delivery with image-guided nerve blocks and programmed, slow drug release.

Shigeru Saito
Dept.Anesth., Gunma Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 43-43, 2007.

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S3C1-5 Nociceptin/Orphanin FQ Receptors:Pharmacology and Clinical Implications

Lih-Chu Chiou
Department of Pharmacology, College of Medicine, National Taiwan University
Journal of Pharmacological Sciences 103 (suppl.1) 43-43, 2007.

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S3D1-1 Changes in emotionality under a chronic pain-like state:Pain-induced stress is associated with the activation of astrocytes in the brain

Minoru Narita, Naoko Kuzumaki, Keiichi Niikura, Masami Suzuki, Tsutomu Suzuki
Dept.Toxicol., Hoshi Univ.Sch.Pharm.Pharmaceut.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 43-43, 2007.

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S3D1-2 Development and application of stress DNA chip

Kazuhito Rokutan, Tomoko Kawai, Kyoko Morita, Kiyoshi Masuda
Dept.Stress Sci., Univ.Tokushima Grad.Sch
Journal of Pharmacological Sciences 103 (suppl.1) 44-44, 2007.

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S3D1-3 The brain mechanism of a failure in adaptation to stress;neuroimaging studies by fMRI and MEG

Yasumasa Okamoto
Dept.Psychiatry ＆ Neurosciences, Hiroshima Univ
Journal of Pharmacological Sciences 103 (suppl.1) 44-44, 2007.

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S3D1-4 Future prospect of drug development for mood disorders based on the studies on stress adaptation

Minoru Tsuji1, 2, Tomoko Yamada2, Teruhiko Matsumiya2, Hiroshi Takeda1, 2
1Dev.Pharmacol., Internat.Univ.Health and Welfare, 2Dept.Pharmacol., Tokyo Med.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 44-44, 2007.

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S3D1-5 Insomnia medication and QOL:Research and development of ramelteon, an MT1/MT2 receptor agonist

Masaomi Miyamoto
Pharmaceut.Develop.Div., Takeda Pharmaceut.Comp.Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 44-44, 2007.

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S3B2-1 Autophagy is activated for cell survival after ER stress

Kazunori Imaizumi
Div.Mol.Cell.Biol., Dept.Anatomy, Faculty of Medicine, Univ.Miyazaki
Journal of Pharmacological Sciences 103 (suppl.1) 45-45, 2007.

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S3B2-2 Involvement of endoplasmic reticulum stress in neuronal cell damage

Hideaki Hara
Dept.Biofunctional Mol., Gifu Pharmaceutical Uni
Journal of Pharmacological Sciences 103 (suppl.1) 45-45, 2007.

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S3B2-3 Characterization of neurotoxicity induced by amyloid β-peptide and tunicamycin in hippocampal slice cultures

Yoshihisa Ito, Toru Imai, Yasuhiro Kosuge, Kumiko Ishige
Res.Unit of Pharmacol., Dept.of Clinical Pharm., Coll.of Pharm.Nihon Univ
Journal of Pharmacological Sciences 103 (suppl.1) 45-45, 2007.

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S3B2-4 Mitochondrial dysfunction and neuronal apoptosis in Alzheimer's disease

Kazuhiro Takuma1, Emiko Fukuzaki1, Taku Nagai1, Hiroyuki Mizoguchi1, David M.Stern2, Shirley ShiDu Yan3, Kiyofumi Yamada1
1Lab.Neuropsychopharmacol., Grad.Sch.Nat.Sci.Technol., Kanazawa Univ., 2Dean's Office, Col.Med., Univ.Cincinnati, 3Dept.Clin.Pathol.＆ Taub Inst., Col.Phys.Surg.Columbia Univ
Journal of Pharmacological Sciences 103 (suppl.1) 45-45, 2007.

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S3B2-5 Involvement of oxidative stress in Alzheimer disease

Akihiko Nunomura
Dept.Psychiatry ＆ Neurol., Asahikawa Med. Coll
Journal of Pharmacological Sciences 103 (suppl.1) 46-46, 2007.

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S3C2-1 Role of actin cytoskeleton in dendritic spines

Tomoaki Shirao
Dept of Neurobiol.＆ Behavior, Gunma Univ.Grad.Sch.of Med
Journal of Pharmacological Sciences 103 (suppl.1) 46-46, 2007.

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S3C2-2 Disturbance of cytoskeletal actinin Alzheimer's disease.

Shoji Mikio
Department of Neurological Science, Institute of Brain Science, Hirosaki University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 46-46, 2007.

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S3C2-3 Short-term turn-over of actin filament binding proteins on lamellipodial actin bundles extended from neural cell.

Hiroyuki Nakagawa
Div.Biol.., Fac.Sci., Fukuoka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 46-46, 2007.

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S3C2-4 Searching novel actin-binding proteins of brain using proteomic strategy

Asako TERASAKI
Graduate School of Science and Technology, Chiba University
Journal of Pharmacological Sciences 103 (suppl.1) 47-47, 2007.

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S3C2-5 Imaging of f-actin and actin associate proteins in neuronal growth cones

Kaoru Katoh1, Sayumi Shirakawa1, Reiko Todaka1, Hiromi Miyoshi1, Mutsumi Ozawa2, Motohiro Nozumi2, Michihiro Igarashi2
1Neurosci.Res.Inst., AIST, 2Div.Molec./Cell.Biol, , Dept.Sign.Transduc., Grad.Sch.Med.Dent.Sci., , Niigata Univ
Journal of Pharmacological Sciences 103 (suppl.1) 47-47, 2007.

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S3C2-6 Biochemical aspect of actin-binding proteins in nerve cell growth cones.

Ryoki Ishikawa, Akio Nakamura, Kazuhiro Kohama
Detp Mol.Cell.Pharmacol., Gunma Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 47-47, 2007.

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S3D2-1 Molecular pharmacology of histamine H1 receptor and its application for development of therapeutics.

Hiroyuki Fukui
Dept.Mol.Pharmacol., Grad.Sch.Health Biosci., Univ.Tokushima
Journal of Pharmacological Sciences 103 (suppl.1) 47-47, 2007.

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S3D2-2 Cognitive functions altered by H1 receptor blockage in human and animal.

Kazuhiko Yanai
Department of Pharmacology, Tohoku University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 48-48, 2007.

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S3D2-3 Social requirements for antihistamines and social impacts of seasonal pollinosis

Nobuo Kubo
Department of Otolaryngology, Kansai Medical University
Journal of Pharmacological Sciences 103 (suppl.1) 48-48, 2007.

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S3D2-4 Effects of antihistamines on psychomotor function in healthy volunteers

Hiroyuki Kamei1, 5, Yukihiro Noda2, 5, Yoshinori Hasegawa3, Ian Hindmarch4, Toshitaka Nabeshima5
1Lab.Clini.Pharm.Prac.Health Care Manage., Facul.Pharm., Meijo University, 2Divi.Clin.Pharm.Neuropsychopharmacol.in Clin Pharm.Prac.Manage.Res., Facul.Pharm, Meijo Univ., 3Dept.Med., Divi.Respi.Dis., Nagoya Univ.Grad.Sch.Med., 4HPRU Med.Res.Centre, Surrey Univ., 5Dept.Neuropsychopharmacol.Hosp.Pharm., Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 48-48, 2007.

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S3D2-5 Evaluation of cognitive and psychomotor profile of newer-generation antihistamines

Ian Hindmarch
The Human Psychopharmacology Research Unit, University of Surrey
Journal of Pharmacological Sciences 103 (suppl.1) 48-48, 2007.

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E1G1-1 Rho-kinase phosphorylates PAR-3 and regulates cell polarity.

Masanori Nakayama1, Takaaki Goto1, Masayuki Sugimoto1, 2, Takashi Nishimura1, 2, Mikio Hoshino3, Shigeo Ohno4, Mutsuki Amano1, Kozo Kaibuchi1
1Dept.Pharmacol., Nagoya Univ.Sch.Med., 2Dept.Vascular Surgery., Nagoya Univ.Sch.Med., 3Dept.Pathology and Tumor Biology, Kyoto Univ., sch.med., 4Dept.Molecular Biology., Yokohama City Univ., Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 50-50, 2007.

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E1G1-2 A new form of Ca2+ signaling (Ca2+ lightning)that conveys cell-cell contact information inside the cells

Kenji Hayashi1, Masaya Hashido1, Kenzo Hirose2, Masamitsu Iino1
1Dept.Pharmacol., Grad.Sch.Med., Univ.Tokyo, 2Dept.Cell Physiol., Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 50-50, 2007.

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E1G1-3 A2-benzazepine derivative promotes skin epithelial cell migration and wound healing.

Kenji Matsuura1, Tomohiro Kuratani2, Toshikazu Gondo3, Akio Kamimura2, Makoto Inui1
1Dept.Pharmacol., Yamaguchi Univ.Grad.Sch.Med., 2Dept.Applied Mol.Biosci.Yamaguchi Univ.Grad.Sch.Med., 3Dept.Surg.Pathol.Yamaguchi Univ.Hosp
Journal of Pharmacological Sciences 103 (suppl.1) 50-50, 2007.

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E1G1-4 Regulation of CSE expression by glucose;a self-defense system against glucose-induced β-cell apoptosis?

Yukiko Kaneko, Toshihide Kimura, Ichiro Niki
Dept.Pharmacol., Oita Univ.Faculty Med
Journal of Pharmacological Sciences 103 (suppl.1) 50-50, 2007.

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E1G1-5 Prorenin activation contributes to the development of insulin resistance in fructose-fed rats.

Yukiko Nagai1, Atsuhiro Ichihara2, Yoshihide Fujisawa1, Hiroshi Ito2, Akira Nishiyama3
1Life Science research center, Kagawa Univ.Sch.Med., 2Dept.Internal Medicine., Keio Univ.Sch.Med., 3Dept.Pharmacol., Kagawa Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 51-51, 2007.

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E1H1-1 Metabolomic analysis of the knockout mice of a novel organic anion transporter OATN1:evaluation of the function and the potential roles as a therapeutic target

Xin He1, Taku Hirata1, Babu Ellappan1, Naohiko Anzai1, Takamasa Ishikawa2, Tomoyoshi Soga2, 3, Hitoshi Entou1, Yoshikatsu Kanai1
1Dept.Pharmacol.＆ Toxicol., Kyorin Univ.Sch.Med., 2Human Metabolome Technologies Inc., 3Institute for Advanced Biosciences, Keio Univ
Journal of Pharmacological Sciences 103 (suppl.1) 51-51, 2007.

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E1H1-2 Production of familial juvenile hyperuricemic nephropathy model mice

Yuichi Takiue, Takuya Yokoo, Masaki Kimura, Makoto Hosoyamada, Toshiaki Shibasaki
Dept.Pharmacotherapeutics, Kyoritsu Univ.Pharmacy
Journal of Pharmacological Sciences 103 (suppl.1) 51-51, 2007.

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E1H1-3 Effect of N-hexacosanol on diabetic cystopathy in the rat

Emi Kazuyama1, Motoaki Saito1, Yoshie Hisadome1, Naho Narimatsu1, Itaru Satoh1, Takuya Hanada1, Hiroto Suzuki2, Masashi Yamada2, Yukako Kinoshita1, Keisuke Satoh1
1Div.Mol.Pharmacol., Tottori Univ.Faculty Med., 2Meiji Dairies Corporation Pharmaceuticals Department
Journal of Pharmacological Sciences 103 (suppl.1) 51-51, 2007.

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E1H1-4 Development of animal models of peritoneal fibrosis and prevented efficacy of a candidate drug

Hiroshi Kato1, Tomohiro Mizuno1, Hayato Nishimura2, Yasuhiko Ito2, Seiichi Matsuo2, Yukihiro Noda1
1Divi.Clin.Sci.Neuropsychopharmacol., Fac.Pharm., Meijo Univ., 2Dept.Nephrol., Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 52-52, 2007.

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E1H2-1 Role of reactive oxygen species in the development of renal interstitial fibrosis in rat remnant kidney

Daisuke Hibi, Saburo Taniuchi, Haruhiko Ohune, Takayuki Kubo, Yuka Kohda, Yoshiko Kawai, Munekazu Gemba
Div.of Pharmacol.Osaka Univ.of Pharmaceut.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 52-52, 2007.

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E1H2-2 Effect of the blockade of opioid receptors on ischemic acute renal failure in the mouse

Junpei Mutoh, Masahiro Ohsawa, Hiroaki Hisa
Second Dept.Pharmacol., Kyushu Univ.of Health and Welfare Sch.Pharm
Journal of Pharmacological Sciences 103 (suppl.1) 52-52, 2007.

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E1H2-3 Changes in Ca2+ mobilization in urinary bladder smooth muscle overexpressing Na+/Ca2+ exchanger(NCX).

Shingo Hotta1, Hidemichi Murata1, Hisao Yamamura1, Susumu Ohya1, Takahiro Iwamoto2, Yuji Imaizumi1
1Dept.Mot.＆ Cell.Pharmacol., Grad.Sch.Pharmaceut.Sci., Nagoya City Univ., 2Dept.Pharmacol., Sch.Med., Fukuoka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 52-52, 2007.

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E1H2-4 An analysis of statin induced muscle injury using isolated skeletal myofibers

Kazuho Sakamoto1, Takashi Honda2, Sachihiko Yokoya3, Satoshi Waguri4, Junko Kimura1
1Dept.Pharmacol., Fukushima Med.Univ.Sch.Med., 2Dept.Human Life Sci., Fukushima Med.Univ.Sch.Nursing, 3Dept.Cell Sci., Fukushima Med.Univ.Inst.Biomed.Sci., 4Dept.Anat.Histol., Fukushima Med.Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 53-53, 2007.

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E1H2-5 Alteration of vascular responsiveness in alpha1A-, 1B- and 1 D- adrenergic receptor triple knockout mouse

Yoko Fujiwara1, Atsushi Sanbe1, Yoshio Tanaka2, Junji Yamauchi1, Katsuo Koike2, Gozoh Tsujimoto3, Akito Tanoue1
1Dev.Exp.Pharmacol., Dept.Pharmacol., NRICHD, 2Dept.Chem.Pharmacol., Toho Univ.Sch.Pharmaceu.Sci., 3Dept.Genomic Drug Discovery Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 53-53, 2007.

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E1H3-1 Involvement of serine protease in hemorrhagic neuronal injury

Shinji Fujimoto, Hiroshi Katsuki, Masatoshi Ohnishi, Toshiaki Kume, Akinori Akaike
Dept.Pharmacol., Grad.Sch.Pharmaceut.Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 53-53, 2007.

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E1H3-2 Effect of endoplasmic reticulum stress on leptin signal transduction

Toru Hosoi, Chie Hashimoto, Tsuyoshi Miyahara, Michiko Yosihi, Koichiro Ozawa
Dept.Pharmacother., Grad.Sch.Biomd.Sci., Hiroshima Univ
Journal of Pharmacological Sciences 103 (suppl.1) 53-53, 2007.

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E1H3-3 The novel mechanism of OxyHb-induced vasoconstriction:MMP activation, HB-EGF shedding, EGFR-PTK activation and Kv channel internalization

Masayo Koide, Masanori Ishiguro, Anthony.D.Morielli, Katarina Zvarova, George.C.Wellman
Department of Pharmacology, University of Vermont College of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 54-54, 2007.

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E1H3-4 Not gelatinase B(MMP9)but stromelysin-1(MMP3)is critical for intracranial bleeding following tissue-type plasminogen activator(tPA)treatment in a mouse stroke model.

Yasuhiro Suzuki1, Nobuo Nagai2, Roger Lijnen2, Desire Collen2, Kazuo Umemura1
1Dept.Pharmacol.Hamamatsu Univ.Sch.Med., 2CMVB, Univ.Leuven, Campus Gasthuisberg, O ＆ N1
Journal of Pharmacological Sciences 103 (suppl.1) 54-54, 2007.

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E1H3-5 Novel 18F-labeled PET probes for in vivo imaging of Aβ pathology in Alzheimer's disease.

Satoshi Ito1, Nobuyuki Okamura1, Motohisa Kato1, Shozo Furumoto2, Hiroyuki Akatsu3, Takayuki Yamamoto3, Hiroyuki Arai4, Yukitsuka Kudo2, Kazuhiko Yanai3
1Dept.Pharmacol., Tohoku Univ.Sch.Med., 2Biomed.Engineer.Res.Org., Tohoku Univ, 3Choju Med Inst., Fukushimura Hosp, 4Dept.Geriat.Geront/Cen Asian Tradi.Med., Tohoku Univ
Journal of Pharmacological Sciences 103 (suppl.1) 54-54, 2007.

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E1H4-1 Analysis of inter- and intramolecular interactions of phox proteins using a new fluorescent protein at cellular levels

Tomoko Kusakabe1, Aya Shimizu1, Takehiko Ueyama1, Takumi Kawasaki1, Yasuhito Shirai1, Satosi Karasawa2, Atsusi Miyawaki2, Naoaki Saito1
1Molecular Pharmacology, Biosignal, Kobe Univ., 2Cell Function, Brain Science, Riken
Journal of Pharmacological Sciences 103 (suppl.1) 54-54, 2007.

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E1H4-2 Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection

Yasu-Taka Azuma1, Richard Flavell2, Tadayoshi Takeuchi1
1Lab.Vet.Pharmacol., Grad.Sch.Life Env.Sci., Osaka Pref.Univ., 2Sect.Immunobiol., Yale Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 55-55, 2007.

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E1H4-3 PGE2-EP1 signaling facilitate Th1 immune response

Daiji Sakata, Miyako Nagamachi, Kenji Kabashima, Tomoyuki Furuyashiki, Kitipong soontrapa, Toshiyuki Matsuoka, Eri Segi-Nishida, Shuh Narumiya
Dept.of Pharmacol, Fuculty of Med., the Univ.of Kyoto
Journal of Pharmacological Sciences 103 (suppl.1) 55-55, 2007.

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E1H4-4 Peroxisome proliferator-activated receptor γ(PPAR γ)agonist augments G protein-mediated stimulation in macrophages;identification of a novel pathway via G protein-coupled receptor.

Kazuhiko Inoue, Atsuro Miyata
Dept.Pharmacol., Kagoshima Univ.Grad.Sch.Med.Dent.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 55-55, 2007.

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E1H4-5 Attenuation of insulin signaling by Cyclosporin A and FK506

Shinya Satoh, Toshihiko Yanagita, Takayuki Nemoto, Norie Yoshikawa, Toyoaki Maruta, Hiroki Yokoo, Hideyuki Kobayashi, Akihiko Wada
Dept.Pharmacol., Miyazaki Med Coll., Univ.Miyazaki
Journal of Pharmacological Sciences 103 (suppl.1) 55-55, 2007.

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E2H1-1 Differentiated astrocytes acquire sensitivity to hydrogen sulfide that is diminished by the transformation into reactive astrocytes

Mamiko Tsugane1, 2, Yasuo Nagai1, 3, Yuka Kimura1, Jun-Ichiro Oka2, Hideo Kimura1
1Dept.Mol.Genetics, Nat'l.Inst.Neurosci., NCNP, 2Lab.Pharmacal., Fac.Pharm.Sci., Tokyo Univ.Sci., 3Dept.Phisiol., Sch.Med., Keio Univ
Journal of Pharmacological Sciences 103 (suppl.1) 56-56, 2007.

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E2H1-2 GABAergic regulation of newborn granule cell migration in the early postnatal hippocampus

Ryuta Koyama, Rieko Muramatsu, Takuya Sasaki, Junya Ichikawa, Norio Matsuki, Yuji Ikegaya
Lab Chem Pharmacol, Grad Sch Pharm Sci, Univ Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 56-56, 2007.

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E2H1-3 Sequential regulation of dendritic spine morphogenesis during development by AMPA-type and NMDA-type glutamate receptors

Hideto Takahashi1, 2, Hiroyuki Yamazaki1, Tomoaki Shirao1
1Dept Neurobiol ＆ Behav, Gunma Univ.Grad.Sch.Med., 2ERCGSM Gunma Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 56-56, 2007.

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E2H1-4 TrkB binds and tyrosine-phosphorylates Tiam1 leading to induction of neurite outgrowth

Yuki Miyamoto, Junji Yamauchi, Atsushi Sanbe, Akito Tanoue
Dept.Pharmacol., Natl.Inst.Child Health Dev
Journal of Pharmacological Sciences 103 (suppl.1) 56-56, 2007.

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E2H1-5 EEG spikes of the hippocampal CA3 neurons lacking NMDA receptors affect the neural activity in the CA1 region.

Kazuhito Nakao1, 2, Fumiaki Fukushima1, 2, Masayoshi Mishina1, 2
1Dept.Mol.Neurobiol.＆ Pharmacol., Sch.Med., Univ.Tokyo, 2SORST/JST, CREST, Japan Science and Technology Corporation
Journal of Pharmacological Sciences 103 (suppl.1) 57-57, 2007.

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E2H2-1 BBB Kit:Blood-Brain-Barrier in vitro Reconstruction Model

Shinsuke Nakagawa1, 5, Maria A Deli2, 5, Shinobu Nakao-Nishioku1, Kentaro Hayashi3, Ryota Nakaoke1, Yasufumi Kataoka4, 5, Masami Niwa1, 5
1Dept.Pharmacol.1, Nagasaki Univ.Grad.Sch.Med., 2Hungarian Academy Sci., 3Dept.Neurosurgery, Nagasaki Univ.Hospital, 4Dept.Pharm.Care Health Sci.Fac.Pharm.Sci., Fukuoka Univ., 5PharmacCo-Cell.Co
Journal of Pharmacological Sciences 103 (suppl.1) 57-57, 2007.

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E2H2-2 Adaptor protein-dependent trafficking of high-affinity choline transporter

Hirofumi Fujigaya1, Takashi Nishimura1, Fubito Nakatsu2, Hiroshi Ohno2, Yasuhiro Moriwaki1, Koichiro Kawashima1, Hidemi Misawa1
1Dept.Pharmacol., Kyoritsu Coll.Pharm, 2RIKEN Research Center for Allergy and Immunology
Journal of Pharmacological Sciences 103 (suppl.1) 57-57, 2007.

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E2H2-3 The effect of combination of the first extracellular domain and the third intracellular loop variants on intracellular signaling of PACAP receptor

Mina Ushiyama1, 2, Hideki Sugawara1, Ryuji Ikeda1, Kazuhiko Inoue2, Katsushi yamada1, Kenji Kangawa3, Atsuro Miyata2
1Dept.Clin.Pharm.and Pharmacol., Grad.Sch.Med.Dent.Sci., Kagoshima Univ., 2Dept.Pharmacol., Grad.Sch.Med.Dent.Sci., Kagoshima Univ., 3Natl.Cardiovasc.Ctr.Res.Inst
Journal of Pharmacological Sciences 103 (suppl.1) 57-57, 2007.

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E2H2-4 Retinoid signaling regulates microglial P2X4 receptor expression and development of allodynia

Hidetoshi Tozaki-Saitoh1, Makoto Tsuda1, Schuichi Koizumi2, Kazuhide Inoue1
1Dept.Mol.Sys.Pharmacol., Grad.Sch.Pharmaceut., Kyushu Univ., 2Div.Pharmacol., Natl.Inst.Hlth.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 58-58, 2007.

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E2H2-5 Effect of gabapentin on sleep parameters in rats

Yasuhiro Takeda1, Tokunaga Shin1, Asae Ohmori1, Hirase Masahiro1, Katsuo Toide2, Chiaki Kamei1
1Depart.Med.Pharmacol., Okayama Univ.Grad.Sch.Med.Dent.＆ Pharm.Sci, 2PGRD Nagoya Laboratories, Pfizer Japan Inc
Journal of Pharmacological Sciences 103 (suppl.1) 58-58, 2007.

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E2H3-1 Social isolation rearing reduces neurogenesis in the hippocampal dentate gyrus of juvenile mice and impairs cognitive and behavioral development.

Daisuke Ibi, Kazuhiro Takuma, Hiroyuki Koike, Hiroyuki Mizoguchi, Kiyofumi Yamada
Lab.Neuropsychopharmacol., Grad.Sch.Nat.Sci.Technol., Kanazawa Univ
Journal of Pharmacological Sciences 103 (suppl.1) 58-58, 2007.

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E2H3-2 The linoleic acid derivative DCP-LA ameliorates impairment of learning and memory

Takahiro Yaguchi, Hideyuki Yamamoto, Hirokazu Fujikawa, Tetsu Nagata, Satoshi Yamamoto, Tomoyuki Nishizaki
Dept.Physiol., Hyogo coll.Med
Journal of Pharmacological Sciences 103 (suppl.1) 58-58, 2007.

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E2H3-3 A novel vanadium compound enhanced neurogenesis and improved memory deficits following ischemia.

Norifumi Shioda1, Kohji Fukunaga1, 2
1Dept.Pharmacol., Tohoku Univ.Grad.Sch.Pharm.Sci., 2Tohoku University 21st Century COE Program CRESCENDO
Journal of Pharmacological Sciences 103 (suppl.1) 59-59, 2007.

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E2H3-4 Mechanisms of the nicotinic receptor up-regulation induced by chronic treatment with donepezil and sensitization to donepezil-induced neuroprotection

Yuki Takada-Takatori1, 2, Toshiaki Kume2, Hiroshi Katsuki2, Tetsuhiro Niidome3, Hachiro Sugimoto3, Takeshi Fujii1, Susumu Okabe1, Akinori Akaike2
1Dept.Pharmacol., Fac.Pharm.Sci., Doshisha Women's College, 2Dept.Pharmacol., Grad.Sch.Pharm.Sci., Kyoto Univ., 3Dept.Neurosci.for Drug Discov., Grad.Sch.Pharm.Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 59-59, 2007.

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E2H3-5 PARK7 DJ-1 has neuroprotective effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration in hemiparkinsonian rat model

Takashi Yanagida1, Masatoshi Inden1, Kazuyuki Takata1, Yoshihisa Kitamura1, Takashi Taniguchi1, Takahiro Taira2, Hiroyoshi Ariga3
1Dept.Neurobiol., 21st Century COE Program, Kyoto Pharm.Univ., 2Dept.Mol.Cell Biol, Interdisci.Grad.Sch.Med.Eng., Yamanashi Univ., 3Dept.Mol.Biol., Grad.Sch.Parm.Sci., Hokkaido Univ
Journal of Pharmacological Sciences 103 (suppl.1) 59-59, 2007.

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E2H4-1 Expression of GABAB receptor in orexin neurons is highly important for proper regulation of wakefulness

Taizo Matsuki1, Mika Nomiyama1, Hitomi Takahira2, Noriko Hirashima2, Masashi Yanagisawa1, 3, Takeshi Sakurai1, 2
1ERATO Yanagisawa Project, JST, 2Dept.Pharmacol., Univ.Tsukuba, 3HHMI, UTSW Med
Journal of Pharmacological Sciences 103 (suppl.1) 59-59, 2007.

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E2H4-2 Morphine causes internalization of the dimeric μ-δ receptors but not μ opioid receptors expressed in baby hamster kidney(BHK)cells.

Yuko Ando1, 2, Minoru Hojo2, Masato Kanaide2, Yuka Sudo1, Koji Sumikawa2, Kohtaro Taniyama1, Yasuhito Uezono1
1Dept.Pharmacol, Nagasaki Univ.Grad.Sch.Biomed.Sci., 2Dept.Anesth.Nagasaki Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 60-60, 2007.

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E2H4-3 Role of corticotropin-releasing factor in the amygdala in relapse to methamphetamine-seeking behavior

Takato Hiranita1, 2, Yoko Nawata1, Kiyoyuki Kitaichi1, Tsuneyuki Yamamoto1
1Dept.Pharmacol., Facult.Pharmaceut.Sci., Nagasaki International Univ., 2Dept.Pharmacol., Facult.Pharmaceut.Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 60-60, 2007.

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E2H4-4 Delayed treatment with cannabidiol has a cerebroprotective action through inhibition of myeloperoxidase

Kazuhide Hayakawa, Kenichi Mishima, Keiichi Irie, Mai Hazekawa, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwara
Dept.Neuropharmacol., Fukuoka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 60-60, 2007.

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E2H4-5 Inhibitory effects of tumor necrosis factor-α and its inducer on drug dependence

Minae Niwa1, Atumi Nitta1, Yuichiro Yamada1, Akira Nakajima1, Kuniaki Saito2, Mitsuru Seishima2, Yukihiro Noda1, 3, Toshitaka Nabeshima1
1Dept.Neuropsychopharmacol.＆ Hosp.Pharm., Nagoya Univ.Grad.Sch.Med., 2Dept.Informative Clin.Med., Gifu Univ.Grad.Sch.Med., Department of Informative Clinical Medicine, Gifu University Graduate School of Medicine, 3Div.Clin.Sci.in Clin.Pharm.Practice, Management ＆ Res., Fac.Pharm., Meijo Univ., Division of Clinical Science in Clinical Pharmacy Practice, Management and Research, Faculty of Pharmacy, Meijo University
Journal of Pharmacological Sciences 103 (suppl.1) 60-60, 2007.

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E2H5-1 DNA demethylation-dependent up-regulation of TLR2 gene in human cystic fibrosis epithelial cells

Tsuyoshi Shuto, Shogo Shimasaki, Takashi Furuta, Yuko Ohira, Mary Ann Suico, Hirofumi Kai
Dept.Mol.Med., Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 61-61, 2007.

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E2H5-2 Ghrelin receptor agonist enhances colorectal motility and defecation in rats.

Yasutake Shimizu1, 2, Anthony.D Shafton3, Gareth.J Sanger4, Jason Witherington4, Takahiko Shiina1, Tadashi Takewaki1, 2, John.B Furness3
1Dept.Vet, Physiol., Gifu Univ., 2Unit.Grad.Sch.Vet.Sci., Gifu Univ., 3Anat.Cell Biol., Univ.Melbourne, 4GlaxoSmith Kline
Journal of Pharmacological Sciences 103 (suppl.1) 61-61, 2007.

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E2H5-3 Different responsiveness of liver myofibroblasts to endothelin-1 and PDGF during the process of cell differentiation

Natsumi Kojima, Takahisa Murata, Yoshihito Morizane, Masatoshi Hori, Hiroshi Ozaki
Dept of Vet Pharmacol, Grad Sch of Agri ＆ Life Sci, The Univ of Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 61-61, 2007.

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E2H5-4 Roles of calcitonin gene-related peptide in facilitation of tumor-associated angiogenesis and tumor growth.

Masaya Toda1, Tatunori Suzuki1, Kanako Hosono1, Sumio Hoka2, Masataka Majima1
1Dept Pharmacol., Kitasato Univ.sch.Med., 2Dept.Anesthesiology., Kitasato Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 61-61, 2007.

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E2H5-5 Anti-metastatic effect of cordycepin, an ingredient of Cordyceps sinensis, is associated with inhibition of platelet aggregation induced by mouse melanoma cells

Noriko Yoshikawa1, Kazuki Nakamura1, Yu Yamaguchi1, Namie Nejime2, Satomi Kagota2, Kazumasa Shinozuka2, Masaru Kunitomo1
1Dept.Pharmacology I, Mukogawa Women's Univ.Sch.Pharmacy and Pharmaceutical Sciences, 2Dept.Pharmacology II, Mukogawa Women's Univ.Sch.Pharmacy and Pharmaceutical Sciences
Journal of Pharmacological Sciences 103 (suppl.1) 62-62, 2007.

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E2H6-1 Proteome analysis of the rat chronic heart failure.

Yoshiki Sanzen1, Yoshimi Ohta1, Tomie Kawada2, Hiroshi Sato3, Yutaka Yoshida4, Yoshimi Nagasaka4, Tadashi Yamamoto4, Mikio Nakazawa1
1Dept.Med.Tech., Sch Health Sci, Fac.Med., Niigata Univ., 2Dept.Clin.Pharmac., Fac.Pharm., Musashino Unive, 3Div Pharmac., Niigata Univ.Hosp., 4Dept.Struc Pathol., Inst.Nephrol., Niigata Grad.Sch.Med.Dent.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 62-62, 2007.

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E2H6-2 TRPC3 and TRPC6 are essential for angiotensin II-induced cardiomyocyte hypertrophy

Motohiro Nishida1, Naoya Onohara1, Ryuji Inoue2, Hideki Sumimoto3, Yoji Sato4, Yasuo Mori5, Taku Nagao4, Hitoshi Kurose1
1Dept.Pharmacol.＆ Toxicol., Grad.Sch.Pharm.Sci., Kyushu Univ., 2Dept.Physiol., Sch.Med., Fukuoka Univ., 3Med.Inst.Bioreg., Kyushu Univ., 4Natl.Inst.of Health Sci., 5Lab.Mol.Biol., Grad.Sch.Eng., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 62-62, 2007.

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E2H6-3 Nuclear translocation of SIRT1 upregulates Mn-SOD and promotes cardiomyocyte survival in failing hearts.

Masaya Tanno1, Jun Sakamoto2, Tetsuji Miura2, Kazuaki Shimamoto2, Yoshiyuki Horio1
1Dept.Pharmacol., Sapporo Medical Univ.Sch.Med, 2Second Dept.Intern Med., Sapporo Medical Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 62-62, 2007.

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E2H6-4 Alteration of OAT3 expression and function induced by angiogenic stimulants

Ryo Sasaki, Masako Yasuda, Yasuna Kobayashi, Masayuki Ohbayashi, Hanako Mizutani, Noriko Kohyama, Toshinori Yamamoto
Dept.Clin.Pharm., Sch.Pharm.Sci., Showa Univ
Journal of Pharmacological Sciences 103 (suppl.1) 63-63, 2007.

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E2H6-5 Lack of apelin results in retardation of retinal vascular development

Atsushi Kasai1, Norihito Shintani1, Hideaki Kato1, Satoshi Matsuda2, Fumi Gomi2, Hitoshi Hashimoto1, 3, Michiya Kakuda3, Yasuo Tano2, Akemichi Baba2
1Lab.Mol.Neuropharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 2Dept.Ophthalmol.Vis.Sci., Grad.Sch.Med, Osaka Univ., 3Center for Child Mental Dev., Grad.Sch.Med, Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 63-63, 2007.

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O1E1-1 Contraction of ileal circular muscle by morphine and its possible involvement in inhibition of intestinal transit in mice

Hiroki Iwata, Shizuko Tsuchiya, Tomonori Nakamura, Shingo Yano
Lab.Mol.Pharmacol.Pharmacother., Grad.Sch.Pharm.Sci., Chiba Univ
Journal of Pharmacological Sciences 103 (suppl.1) 66-66, 2007.

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O1E1-2 Involvement of angiotensin AT1 receptor and NADPH oxidase in the oxidative damage in rat stomach

Akari Nakagiri1, 2, Masaaki Sunamoto1, Motonobu Murakami1
1Department of Pharmacotherapeutics, Doshisha Women's College, 2Dept of Pharmacol.Exp.Therapeutics, Kyoto Pharmaceutical Univ
Journal of Pharmacological Sciences 103 (suppl.1) 66-66, 2007.

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O1E1-3 Correlation of enzymes responsible for generation and detoxification of hydrogen sulfide with inflammatory bowel disease(IBD)in rodents

Eiichi Taniguchi, Daiki Yonezawa, Tsuyoshi Isiki, Maho Matsunami, Fumiko Sekiguchi, Atsufumi Kawabata
Div.Physiol.Pathophysiol., Sch.Pharm., Kinki Univ
Journal of Pharmacological Sciences 103 (suppl.1) 66-66, 2007.

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O1E1-4 Involvement of the gas messenger hydrogen sulfide in pancreatic pain

Osamu Fukushima1, Sachiyo Nishimura1, 3, Hiroyasu Ishikura2, 3, Tomoko Takahashi1, Maho Matsunami1, Fumiko Sekiguchi1, Mitsuhide Naruse3, Yoshihisa Kamanaka4, Atsufumi Kawabata1
1Div.Physiol.Pathophysiol., Sch.Pharm., Kinki Univ., 2Div.Emerg.Crit.Care Med., Natl.Hosp.Org., Kyoto Med.Cent., 3Div.of Endocrin., Clin.Res.Inst.Endocrin.Met.Dis., Natl.Hosp.Inst.Endocrin.Met.Dis., Natl.Hosp.Org., Kyoto Med.Cent., 4Ono Phamaceut.Co., Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 66-66, 2007.

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O1E1-5 Different functional roles of M2 and M3 receptors in gastric contraction induced by carbachol and nerve stimulation

Takio Kitazawa1, Kano Hashiba1, Jinshan Cao1, Toshihiro Unno2, Sei-ichi komori2, Masahisa Yamada3, Jurgen Wess4, Tetsuro Taneike1
1Dept.Pharmacol.Sch.Vet.Med.Rakuno Gakuen Univ., 2Lab.Pharmacol., Faculty ofApplied Biol.Sci., Gifu Univ., 3Lab.Neurogenetics, Molecular Neuropathology Group, Brain Sci.Institute, RIKEN., 4Lab.Bioorganic Chem.National Institute of Diabetes, Digestive and Kidney Diseases
Journal of Pharmacological Sciences 103 (suppl.1) 67-67, 2007.

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O1F1-1 PPAR γ controls cell growth through the expression of GCLC in various carcinoma cell lines.

Hiroyuki Ishida1, Koichiro Wada1, Tomotake Masuda2, Atsushi Nakajima3, Masaya Okura2, Mikihiko Kogo2, Yoshinori Kamisaki1
1Dept.Pharmacol., Osaka Univ.Sch.Dent., 2Dept.Oral and Maxillofacial Surg 1, Osaka Univ.Sch.Dent., 3Gastroenterol.Div., Yokohama City Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 67-67, 2007.

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O1F1-2 Molecular mechanism of β subunit-selective BK channel activation by DiBAC4(3)

Takashi Morimoto, Susumu Ohya, Yuji Imaizumi
Dept.Mol.＆ Cell.Pharmacol., Grad.Sch.Pharmaceut.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 103 (suppl.1) 67-67, 2007.

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O1F1-3 Roles of Ca-calmodulin in superoxide production and chemotaxis of FMLP-stimulated rat neutrophils

Yukio Azuma, Msanori Kashimata
Dept.Dental Pharmacol., Asahi univ.Sch.Dent
Journal of Pharmacological Sciences 103 (suppl.1) 67-67, 2007.

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O1F1-4 GPCR agonists suppress EGF-induced ERK5 phosphorylation in PC12 cells.

Yumiko Okano1, Sachiko Ono1, Yutaro Obara1, 2, Norimichi Nakahata1, 2
1Dept.Cellular Signal., Grad.Sch.of Pharmaceut.Sci., Tohoku Univ., 2 21st Century COE Program "CRESCENDO"
Journal of Pharmacological Sciences 103 (suppl.1) 68-68, 2007.

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O1G1-1 Junctophilin-mediated functional coupling of channels essential for cerebellar synaptic plasticity

Sho Kakizawa1, Yasushi Kishimoto2, Sin-ya Saito3, Kouichi Hashimoto2, Taisuke Miyazaki4, Kazuharu Furutani1, Miyuki Nishi3, 5, Hiroyuki Sakagami6, Hisatake Kondo6, Masanobu Kano2, Masahiko Watanabe4, Masamitsu Iino1, Hiroshi Takeshima3, 5
1Dept.Pharmarol., Grad.Sch.Med., The Univ.of Tokyo, 2Dept.Cell.Neurosci., Grad.Sch.Med., Osaka Univ., 3Dept.Med.Chem., Tohoku Univ.Grad.Sch.Med., 4Dept.Anat., Grad.Sch.Med., Hokkaido Univ., 5Dept.Biol.Chem., Grad.Sch.Pharmaceut.Sci., Kyoto Univ., 6Dept.Cell.Biol., Tohoku Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 68-68, 2007.

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O1G1-2 Septo-hippocampal cholinergic neurodegeneration contributes to the memory deficit in OBX mice

feng han1, Shigeki Moriguchia1, Norifumi Shioda1, Kohji Fukunaga1, 2
1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 2Tohoku University 21st Century COE Program
Journal of Pharmacological Sciences 103 (suppl.1) 68-68, 2007.

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O1G1-3 Changes in central dopaminergic neuron development with expression of sonic hedgehog(Shh)or glial cell line-derived neurotrophic factor(GDNF)in mice prenatally and neonatally exposed to bisphenol-A

Kazuya Miyagawa, Minoru Narita, Michiko Narita, Keiichi Niikura, Hisahiko Akama, Yuri Tsurukawa, Tsutomu Suzuki
Dept.Toxicol., Hoshi Univ.Sch.Pharm.Pharmaceut.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 68-68, 2007.

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O1G1-4 Studies on pain control system (Rept.63):Chronic pain-induced astrocyte growth in the cingulate cortex with no change in neural and glial differentiation from neural stem cells in the subventricular zone of mice

Naoko Kuzumaki1, Minoru Narita1, Michiko Narita1, Nana Hareyama1, Keiichi Niikura1, Taku Amano2, Tsutomu Suzuki1
1Dept.Toxicol., Hoshi Univ.Sch.Pharm., 2Dept.Mol.Pharmacol.Neurosci., Grad.Sch.Biomed.Sci., Hiroshima Univ
Journal of Pharmacological Sciences 103 (suppl.1) 69-69, 2007.

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O1G1-5 Effect of acute treatment with neuron/astrocyte conditioned medium activated by the stimulation of 5-HT1A receptor on the anxiolytic behavior

Kazuya Miyagawa1, Minoru Narita1, Minoru Tsuji2, Hiroshi Takeda2, Tsutomu Suzuki1
1Dept.Taxicol., Hoshi Univ.Sch.Pharm.Pharmaceut.Sci., 2Dev.Pharmacol., Internat.Univ.Health and Welfare
Journal of Pharmacological Sciences 103 (suppl.1) 69-69, 2007.

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O1I1-1 Aspirin prevents cerebrovascular injury in salt-loaded stroke-prone rats by suppression of oxiadtive stress

Toshiaki Ishizuka, Atsuko Niwa, Masaki Tabuchi, Kana Ohshima, Yusuke Nagatani, Hideaki Higashino
Dept.Pharmacol, Kinki Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 69-69, 2007.

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O1I1-2 Long-term administration of Eucommia ulmoides Oliv.leaf extract improves age-related deficiency of endothelium-dependent inhibitory effect on methoxamine-induced excess vasoconstriction in aged rat mesenteric resistance arteries

Xin Jin1, Yukiko Otonashi1, Takashi Tsuboi2, Naomi Kawamura2, Chie Tagawa3, Fusako Takayama1, Hiromu Kawasaki1
1Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ, 2R＆D Center, Kobayashi Pharmaceutical Co., Ltd, 3Hitachi Zosen corporation, Technology Headquarters, Technical Research Institute
Journal of Pharmacological Sciences 103 (suppl.1) 69-69, 2007.

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O1I1-3 Effect of postprandial hyperglycemia with various plasma insulin concentrations on neurogenic vascular reaction

Yoshito Zamami1, Shingo Takatori2, Kousuke Yamawaki1, Satoko Miyashita1, Nana Yabumae1, Husako Takayama1, Mitsunobu Mio2, Hiromu Kawasaki1
1Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ., 2Lab Pharmacol., Dept.Clin.Pharm.Sch.Pharm., Shujitsu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 70-70, 2007.

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O1I1-4 Vascular nitric oxide(NO)-containing nerves regulate adrenergic neurotransmission in mesenteric resistance arteries of hypertensive rat.

Toshihiro Koyama, Chiyo Shouji, Yukako Hatanaka, Mitsuhiro Gouda, Narumi Houbara, Fusako Takayama, Hiromu Kawasaki
Dept.Clin.Pharmc.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ
Journal of Pharmacological Sciences 103 (suppl.1) 70-70, 2007.

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O1E2-1 HGF increases the uptake of estradiol 17β-D-glucuronide through up-regulation of Oatp1 protein level in primary cultured rat hepatocytes

Tomomi Iwakiri1, Manabu Okumura1, Emi Ichihara1, Satoshi Shiotsuki1, Masashi Nagata1, Yuki Kumagai1, Hirofumi Kai2, Kazuhiko Arimori1
1Dept.Pharmacy., Facul.Med., Miyazaki Univ., 2Dept.Molecul.Med., Facul.Pharm.Scien., Kumamoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 70-70, 2007.

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O1E2-2 Functional analysis of TRP isoforms expressed in human colonic myofibroblast cell line CCD-18Co

Lin Hai, Akira Honda, Ryuji Inoue
Dept.Physiol., Fukuoka Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 70-70, 2007.

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O1E2-3 Angiotensin II produced by chymase in human cirrhotic livers

Koji Komeda1, 2, Denan Jin1, Shinji Takai1, Michihiro Hayashi2, Nobuhiko Tanigawa2, Mizuo Miyazaki1
1Dept.of Pharmacol., Osaka Medical College, 2Dept.of General and Gastroenterological Surgry, Osaka Medical College
Journal of Pharmacological Sciences 103 (suppl.1) 71-71, 2007.

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O1E2-4 COX-2/PGE2 Accelerates Healing of Gastric Ulcers Through Up-Regulation of VEGF via EP4 Receptors

Mayu Tanigami, Akiko Tanaka, Ryo Hatazawa, Yuka Takahira, Koji Takeuchi
Dept.of Pharmacol.＆ Exp.Ther., Kyoto Pharmaceutical University
Journal of Pharmacological Sciences 103 (suppl.1) 71-71, 2007.

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O1F2-1 A role of reactive oxygen species in adipogenesis using mesenchymal stem cells

Yasunari Kanda, Takashi Hinata, Yasuhiro Watanabe
Dept.Pharmacol., Natl.Def.Med.Col
Journal of Pharmacological Sciences 103 (suppl.1) 71-71, 2007.

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O1F2-2 Geldanamycin-induced down-regulation of IRS-1 and up-regulation of IRS-2:opposite reguation by Hsp90

Norie Yoshikawa, Toshihiko Yanagita, Shinya Satoh, Toyoaki Maruta, Takayuki Nemoto, Hiroki Yokoo, Hideyuki Kobayashi, Akihiko Wada
Dept.Pharmacol., Miyazaki Med.Coll., Univ.Miyazaki
Journal of Pharmacological Sciences 103 (suppl.1) 71-71, 2007.

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O1F2-3 A model for mitochondrial myopathy;AZT-triphosphate toxicity.

Takeya Sato1, 2, Jun Sukegawa1, Jeffrey Medin2, Teruyuki Yanagisawa1
1Dept.Mol.Pharmacol., Tohoku Univ.Grad.Sch.Med., 2UHN, University of Toronto
Journal of Pharmacological Sciences 103 (suppl.1) 72-72, 2007.

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O1F2-4 Critical role of exposure time to oxidative stress in hepatocyte apoptosis

Yasuhiro Ishihara, Norio Shimamoto
Facul.Pharma.Sci.Kagawa Campus, Tokushima Bunri Univ
Journal of Pharmacological Sciences 103 (suppl.1) 72-72, 2007.

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O1G2-1 Studies on pain control system(Rept.64):Effect of paroxetine on antinociceptive and anxiolytic effect under a neuropathic pain-like state

Keiichi Niikura1, Minoru Narita1, Kiyomi Yanagida2, Ayumi Ozeki1, Yasuhisa Kobayashi1, Naoko Kuzumaki1, Kana Nanjo1, Mioko Terada2, Mitsuaki Yamazaki2, Tsutomu Suzuki1
1Dept.Toxicol., Hoshi Univ.Sch.Pharm.Pharmaceut.Sci., 2Dept.Anesthesiol., Univ.of Toyama
Journal of Pharmacological Sciences 103 (suppl.1) 72-72, 2007.

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O1G2-2 Studies on drug dependence(Rept.425):Drugs of abuse induced cell differentiation

Megumi Asato, Minoru Narita, Michiko Narita, Naoko Kuzumaki, Nana Hareyama, Tsutomu Suzuki
Dept.Toxicol., Hoshi Univ.Sch.Pharm.Pharmaceut.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 72-72, 2007.

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O1G2-3 Studies on pain control system(Rept.62):Different profiles of morphine and oxycodone under a neuropathic pain-like state in mice

Atsushi Nakamura, Minoru Narita, Kan Miyoshi, Masami Suzuki, Ayumi Ozeki, Tsutomu Suzuki
Dept.Toxicol., Hoshi Univ.Sch.Pharm.Pharmaceut.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 73-73, 2007.

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O1G2-4 Involvement of Rho-kinase signaling on simvastatin-induced attenuation of the nerve injury-induced thermal hyperalgesia in the mouse.

Masahiro Ohsawa, Junpei Mutoh, Hiroaki Hisa
2nd Dept.Pharmacal., Kyushu Univ.Health Welfare
Journal of Pharmacological Sciences 103 (suppl.1) 73-73, 2007.

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O1I2-1 Determination of calcium and contractile responses of rat cerebral artery employing real-time confocal laser microscopy.

Terumasa Hashimoto, Hisayuki Ohata, Kazuo Honda
Dept.Pharmacol., Showa Univ.Sch.Pharm
Journal of Pharmacological Sciences 103 (suppl.1) 73-73, 2007.

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O1I2-2 Imbalance of calcineurin/CaMKII activities triggers disturbance of SR calcium release

Yingmei Lu1, Yasufumi Shirasaki2, Kohji Fukunaga1, 3
1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, 2Dayiichi Pharmaceutical CO., LTD, 3Tohoku University 21st Century COE Program
Journal of Pharmacological Sciences 103 (suppl.1) 73-73, 2007.

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O1I2-3 Characteristics of automatic activity in knock-in mouse model of dilated cardiomyopathy associated with △ K210 in cardiac troponin T

Nagomi Kurebayashi1, Akihito Chugun1, Hiroto Nishizawa2, Yuji Nakazato2, Hiroyuki Daida2, Takashi Sakurai1, Sachio Morimoto3
1Dept.Pharmacol.Juntendo Iniv.Sch.Med, 2Dept.Cardiol.Juntendo Univ.Sch.Med., 3Dept.Clin.Pharmacol.Med.Sch.Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 74-74, 2007.

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O1I2-4 Function of endothelial nitric oxide(NO)in rabbit posterior cerebral artery(PCA)under oxidative stress

Yoshimasa Watanabe, Nobuyoshi Kusama, Junko Kajikuri, Takeo Itoh
Dept.Cellular and Molecular Pharmacol., Graduate Sch.Med.Sciences, Nagoya City Univ
Journal of Pharmacological Sciences 103 (suppl.1) 74-74, 2007.

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O1E3-1 Effect of Peptide Histidine Isoleucine(PHI)on Duodenal HCO3 Secretion in Rats

Eitaro Aihara, Yoko Sasaki, Fumitaka Ise, Koji Takeuchi
Dept.of Pharmacol.＆ Exp.Ther., Kyoto Pharmaceutical University
Journal of Pharmacological Sciences 103 (suppl.1) 74-74, 2007.

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O1E3-2 Pathogenic Importance of Pepsin in Ischemia/Reperfusion-induced Gastric Injury

Tohru Kotani, Atsushi Kobata, Yukiko Murashima, Kikuko Amagase, Koji Takeuchi
Dept.of Pharmacol.＆ Exp.Ther., Kyoto Pharmaceutical University
Journal of Pharmacological Sciences 103 (suppl.1) 74-74, 2007.

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O1E3-3 Gastric mucosal protection through the inhibition of Leukotriene C4 production by an EP2 agonist and an EP4 agonist

Youichiro Hattori1, 2, Takasi Ohno3, Takeo Saeki2, Sumito Mizuguchi3, Katsuharu Arai4, Katsunori Saigenji2, Masataka Majima1
1Dept.Pharmacolo., Kitasato Univ.Sch.Med, 2Dept.Gastroenterology., Kitasato Univ.Sch.Med, 3Dept.Gastoroenterology., Isehara Kyodo Hosp., 4Dept.Gastroenterology., Yokosuka Kyosai Hosp
Journal of Pharmacological Sciences 103 (suppl.1) 75-75, 2007.

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O1E3-4 Effects of N-hexacosanol on diabetic induced dysfunction of rat ileum

Naho Narimatsu1, Motoaki Saito1, Emi Kazuyama1, Yoshie Hisadome1, Itaru Satoh1, Takuya Hanada1, Hiroto Suzuki2, Masashi Yamada2, Yukako Kinoshita1, Keisuke Satoh1
1Div.Mol.Pharmacol., Tottori Univ.Faculty Med., 2Meiji Dairies Corporation Pharmaceuticals Department
Journal of Pharmacological Sciences 103 (suppl.1) 75-75, 2007.

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O1F3-1 Anti-diabetic effects of exendin-4 may involve suppression of endoplasmic reticulum stress in the beta cell.

Ichiro Niki1, Shin Tsunekawa2, Yukiko Kaneko1, Toshihide Kimura1, Yutaka Oiso2
1Dept.Pharmacol., Oita Univ.Faculty Med., 2Dept.Endocrinol.and Diabetol., Nagoya Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 75-75, 2007.

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O1F3-2 Phathophysiological Genomics of Novel Metabolic Syndrome Model in Zebrafish

Yasuhito Shimada, Takehiko Oka, Liqing Zang, Toshio Tanaka
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 75-75, 2007.

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O1F3-3 Generation and pathophysiological genomics analysis for juvenile metabolic syndrome model

Minoru Hirano, Toshio Tanaka
Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics Mie University Graduate School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 76-76, 2007.

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O1F3-4 The characterization of rat GPR34 as a lyso-phosphatidylserine receptor.

Maya Yamato, Kazuhiko Inoue, Shin-ichi Iwata, Takao Shimizu, Atsuro Miyata
Dept.Pharmacol., Kagoshima Univ.Grad.Sch.Med.Dent.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 76-76, 2007.

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O1G3-1 Ischemia-related neuronal death in female SHRSP

Yasuko Sakurai-Yamashita, Hidekazu Kinugawa, Masami Niwa
Dept.Pharmacol., Nagasaki Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 76-76, 2007.

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O1G3-2 Inhibiting effect of PDGF-BB on AMPA receptor mediated excitatory synaptic transmission in second-order neurons of the nucleus tractus solitarius in mouse brainstem slices.

Yoshiaki Ohi1, Yoko Ishii2, Akira Haji3, Masakiyo Sasahara2, Yuichi Hattori1
1Dept.Mol.＆ Med.Pharmacol., Grad.Sch.Med.＆ Pharm.Sci., Univ.of Toyama, 2Dept.2nd Pathol., Grad.Sch.Med.＆ Pharm.Sci., Univ.of Toyama, 3Lab.Neuropharmacol., Sch.Pharm., Aichi Gakuin Univ
Journal of Pharmacological Sciences 103 (suppl.1) 76-76, 2007.

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O1G3-3 Involvement of brain phosphatidylinositol-specific phospholipase C/diacylglycerol lipase in the histamine-induced activation of central adrenomedullary outflow in rats

Takahiro Shimizu1, Shoshiro Okada1, Naoko Yamaguchi1, Tsuyoshi Sasaki1, 2, Kumiko Nakamura1, Lianyi Lu1, Kunihiko Yokotani1
1Dept.Pharmacol., Grad.Sch.of Med., Kochi Univ., 2Dept.Pediatrics, Grad.Sch.of Med., Kochi Univ
Journal of Pharmacological Sciences 103 (suppl.1) 77-77, 2007.

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O1G3-4 The histaminergic system is a promising target for the treatment of leptin resistant obesity

Tomoko Ishizuka1, Kouta Hatano2, Atsushi Yamatodani1, 2
1Molecular Research Center for Child Mental Development, Fac Med, Osaka Univ, 2Dept Medical Science and Technology, Grad Sch Allied Hlth Sci, Fac Med, Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 77-77, 2007.

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O1G3-5 Threshold regulation of LTD at PF-PC synapses is crucial for the efficiency of OKR gain-increase adaptation

Tomonori Takeuchi1, Gen Ohtsuki2, Takashi Yoshida2, Masahiro Fukaya3, Masahiko Watanabe3, Tomoo Hirano2, Masayoshi Mishina1
1Dept Mol Neurobiol ＆ Pharmacol, Sch Med, Univ Tokyo ＆ SORST/JST, 2Dept Biophys, Grad Sch Sci, Kyoto Univ ＆ CREST/JST, 3Dept Anat, Hokkaido Univ Sch Med
Journal of Pharmacological Sciences 103 (suppl.1) 77-77, 2007.

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O1I3-1 Telmisartan improves abnormal vasorelaxation in mesenteric arteries of SHR/NDmcr-cp rats, an animal model of metabolic syndrome

Satomi Kagota, Yukari Tada, Namie Nejime, Kazuki Nakamura, Masaru Kunitomo, Kazumasa Shinozuka
Dept.Pharmacol., Sch.of Pharmaceu.Sci., Mukogawa Women's Univ
Journal of Pharmacological Sciences 103 (suppl.1) 77-77, 2007.

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O1I3-2 Cardiac α1 D-adrenoceptor deficiency may exert counteracting effect on ischemia-induced exacerbation of contractile dysfunction in α1 B-AR-deficient mice

Yoshihisa Nasa1, Takashi Tomabechi2, Ryo Oikawa2, Yuji Kawahara2, Rie Ishii2, Naoko Suzuki2, Satoshi Takeo2, Akito Tanoue3, Gozoh Tsujimoto4
1Dept.Funct.Morphol.Sci.Nihon Pharm.Univ., 2ept.Mol.Cell.Pharmacol., Tokyo Univ.Pharm.Life Sci., 3Dept.Mol.Cell.Pharmacol.Natl.Center Child Health Devel.Res.Inst., 4Dept.Genom.Drug Discov.Sci., Pharm.Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 78-78, 2007.

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O1I3-3 Functional role of nitrergic nerve derived from sphenopalatine ganglion in the regulation of nasal mucosa blood flow in anesthetized rats

Masakazu Hanamitsu1, Kazuhide Ayajiki2, Takumi Tamayama2, Kazuya Shinozaki2, Takeshi Shimizu1, Tomio Okamura2
1Dept.Otolaryngol., Shiga Univ.Med.Sci., 2Dept.Pharmacol., Shiga Univ.Med.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 78-78, 2007.

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O1I3-4 RNH-6270, angiotensin II receptor blocker inhibits TNF-α-induced cytotoxicity in endothelial cells

Hironori Taira1, Keisuke Ishizawa2, Narantungalag Dorjsuren2, Yuki Izawa2, Erika Miki2, Arisa Hironaga1, Yuki Motobayashi2, Kazuyoshi Kawazoe1, Kazuo Minakuchi1, Toshiaki Tamaki2
1Dept.Pharmacy, Tokushima Univ.Hosp., 2Dept.Pharmacol., Inst.HBS, Univ.Tokushima Grad.Sch
Journal of Pharmacological Sciences 103 (suppl.1) 78-78, 2007.

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O1E4-1 Methoxyflavones protect cells against endoplasmic reticulum(ER)stress and neurotoxin

Katsura Takano1, Yoshiyuki Tabata2, Yasuko Kitao2, Rika Murakami3, Hiroto Suzuki3, Masashi Yamada3, Munekazu Iinuma4, Yukio Yoneda1, Satoshi Ogawa2, Osamu Hori2
1Lab.Mol.Pharmacol., Kanazawa Univ.Grad.Sch.Nat.Sci.Tech., 2Dept.Neuroanacomy, Kanazawa Univ.Grad.Sch.Med.Sci., 3Meiji Dairies Corporation, 4Gifu Pharm.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 78-78, 2007.

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O1E4-2 Effect of theanine on lipid hydroperoxide-induced rabbit corneal neovascuralization

Takako Nakanishi-Ueda1, 2, Toshihiko Ueda2, Tsutomu Shimada3, Masaki Aburada3, Satoshi Yano1, Ryohei Koide2, Hajime Yasuhara1
1Dept.Pharmacol., Sch.Med.Showa Univ., 2Dept.Ophthalmol., Sch.Med.Showa Univ., 3Facul.Pharm., Res.Inst.Pharm.Sci., Musashino Univ
Journal of Pharmacological Sciences 103 (suppl.1) 79-79, 2007.

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O1E4-3 Single Cell Manipulation System by Using Microfluidic Technology:Application for Pharmacological Analysis

Hisayoshi Hamada1, 2, Takahiro Arakawa2, Tatsuya Saito2, Kiyotaka Sakai2, Shuichi Shoji2, Yoshinori Yamaguchi1, Naoya Takeda1, Yoshikuni Edagawa1
1Inst.Biomed.Eng., Waseda Univ., 2Grad.Sch.Sci.and Eng., Waseda Univ
Journal of Pharmacological Sciences 103 (suppl.1) 79-79, 2007.

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O1F4-1 Dual effect of nitric oxide(NO)on KATP channels in rat pancreatic β-cells

Takaaki Sunouchi, Koichi Nakayama, Tomohisa Ishikawa
Dept.Cell.Mol.Pharmacol., Grad.Sch.Pharmaceut.Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 103 (suppl.1) 79-79, 2007.

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O1F4-2 Enhancement of glucose-induced insulin release in the pancreatic islets of ghrelin knockout mice

Katsuya Dezaki, Toshihiko Yada
Dept.Physiol., Jichi Med.Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 79-79, 2007.

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O1F4-3 Conophylline and Betacellulin δ 4 Promote Differentiation of Pancreatic β cells both in vitro and in vivo

Tsutomu Kodera1, 2, Takeki Ogata2, 3, Yoritsuna Yamamoto2, 3, Kazuo Umezawa4, Masaharu Seno5, Yuji Tanaka3, Itaru Kojima2, Yasuhiro Watanabe1
1Dept.Pharmacol., Ntnl.Def.Med.Col.Japan, 2IMCR, Gunma Univ., 3Endocrinology Dept., Ntnl.Def.Med.Col.Japan, 4Fclty.of Sci.and Tech., Keio Univ., 5Grad.Sch.of Nat.Sci.and Tech., Okayama Univ
Journal of Pharmacological Sciences 103 (suppl.1) 80-80, 2007.

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O1I4-1 The role of apoptosis signal-regulating kinase1(ASK1)in high-fat diet(HFD)-induced obesity and diabetes

Yi.Fei Dong, Eiichiro Yamamoto, Takuro Yamashita, Taishi Nakamura, houichi Yorinaka, Kiichiro Kataoka, Yoshiko Tokutomi, Shokei Mitsuyama.Kim
Dept.Pharmacology and Molecular Therapeutics Kumamoto Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 80-80, 2007.

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O1I4-2 Ca2+-dependent facilitation and inactivation of the L-type Ca2+ channel:the roles and relations of Ca2+, calmodulin and calmdulin dependent kinase II

Li-Ying Hao1, 2, Dong-Yun Han2, Etsuko Minobe2, Hong-Guang Nie2, Wu-Yang Wang2, Jian-Jun Xu2, Zahangir A.Saud2, Masaki Kameyama2
1Dept.Pharm.Toxicol., China Med.Univ.Sch.Pharm., 2Dept.Physiol., Kagoshima Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 80-80, 2007.

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O1I4-3 Apocynin normalizes hyperreactivity to phenylephrine in mesenteric arteries from cholesterol-fed mice by improving endothelium-derived hyperpolarizing factor response

Takayuki Matsumoto, Tsuneo Kobayashi, Katsuo Kamata
Dept.Physiol.and Morphol., Inst.Med.Chem., Hoshi Univ
Journal of Pharmacological Sciences 103 (suppl.1) 80-80, 2007.

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O1I4-4 Angiotensin II type 2 receptor contributes to the development of hypertension in spontaneously hypertensive rats(SHR).

Fumiaki Kimura, Katsutoshi Yayama, Hiroshi Okamoto
Cardiovascular Pharmacol, Kobe Gakuin Univ.Sch.Pharmaceutical Sciences
Journal of Pharmacological Sciences 103 (suppl.1) 81-81, 2007.

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O2E1-1 Effect of pioglitazone on the signal transduction system in the fatty liver of sucrose and high fat diet treated spontaneously hypertensive hyperlipidemic rats(SHHR)

Toshio Kumai1, Yuko Takeba1, Naoki Matsumoto1, Sachiko Nakaya1, Shigeko Oonuma2, Mamoru Tadokoro2, Shinichi Kobayashi1
1Dept.Pharmacol., St.Marianna Univ.Sch.Med., 2Dept.Pathol., St.Marianna Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 81-81, 2007.

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O2E1-2 Functions of human receptor activity-modifying protein 2(RAMP2)during adrenomedullin(AM)receptor internalization

Kenji Kuwasako, Kazuo Kitamura
Circulatory and Body Fluid Regulation, Faculty of Med., Univ.Miyazaki
Journal of Pharmacological Sciences 103 (suppl.1) 81-81, 2007.

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O2E1-3 The hypoglycemic effect of the extract from the root of Molinda citrifolia

Wakako Hamabe1, Rie Murakami1, Hiromi Kawakami1, Eri Shibahara1, Sachiko Harada2, Kohei Kamiya2, Toshiko Satake2, Shogo Tokuyama1
1Dept.Clinic.Pharm., Fac.Pharmaceu.Sci., Kobe Gakuin Univ., 2Dept.Pharmacogn.and Nat.Prod.Chem., Fac.Pharmaceu.Sci., Kobe Gakuin Univ
Journal of Pharmacological Sciences 103 (suppl.1) 81-81, 2007.

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O2E1-4 Redox balance disorder caused by hindlimb ischemia in mice

Kei Sato1, Yoshihiko Otsuka1, Takaaki Fujii2, Mayumi Yamato1, Toshiaki Watanabe1
1Dept.REDOX Medical Science., Pharmaceutical., Kyushu Univ, 2Dept.Pathology., l., Kyushu Univ, .Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 82-82, 2007.

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O2F1-1 Suppression of tumor growth by nerve growth factor in mice in vivo

Mitsuhiro Goda, Saori Atagi, Keisuke Amitani, Narumi Hobara, Yoshihisa Kitamura, Fusako Takayama, Hiromu Kawasaki
Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ
Journal of Pharmacological Sciences 103 (suppl.1) 82-82, 2007.

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O2F1-2 Hydrogen sulfide is a novel nociceptive messenger in processing of colonic pain

Maho Matsunami1, Kazumasa Okubo1, Osamu Fukushima1, Motohide Takemura2, Atsufumi Kawabata1
1Div.Physiol.Pathophysiol., Sch.Pharm., Kinki Univ., 2Dept.Oral Anat.Neurobiol., Osaka Univ.Grad.Sch.Dent
Journal of Pharmacological Sciences 103 (suppl.1) 82-82, 2007.

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O2F1-3 Characterization of muscarinic receptor(mR)binding after oral administration of anticholinergic agents in muscarinic M2 knockout mice

Oyunzul Luvsandorj1, Tomomi Fujino1, Masanao Seki1, Yukiko Noguchi2, Hironori Yuyama2, Akiyoshi Ohtake2, Masanori Suzuki2, Masao Sasamata2, Minoru Matsui3, Shizuo Yamada1
1Dept.of Pharmacokinet.＆ Pharmacodyn., Sch.of Pharm Sci., Univ.of Shizuoka, 2Pharmacol.Res.Labs., Drug Dis.Res., Astellas Pharma Inc., 3Div.of Neuronal Network, Dept.of Basic Medical Sci., Inst.of Medical Sci., Univ.of Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 82-82, 2007.

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O2G1-1 The role of prostanoid in mouse restraint-stress model

Yukio Kiriu, Eriko Iguchi, Yasuhiro Tanaka, Toshiyuki Matsuoka, Shuh Narumiya
Dept.Pharmacol., Kyoto Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 83-83, 2007.

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O2G1-2 ERK activation in spinal microglia contributes to diabetes-induced allodynia

Hikaru Ueno, Makoto Tsuda, Kazuhide Inoue
Dept.Mol.Syst.Pharmacol., Grad.Sch.Pharm.Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 83-83, 2007.

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O2G1-3 Involvement of amyloid-β in retinal cell death

Masamitsu Shimazawa1, Yuta Inokuchi1, Gaku Sakaguchi2, Akira Kato2, Takashi Kudo3, Masatoshi Takeda3, Hideaki Hara1
1Dept.Biofunct.Mol., Gifu Pharmaceut.Univ., 2Disc.Res.Labs, Shionogi and Co., Ltd., 3Dept.Psychiatry, Osaka Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 83-83, 2007.

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O2G1-4 Effects of Transient Ischemia on Flavoprotein Fluorescence and Somatosensory Evoked Potential

Takahiro Igarashi, Noriaki Yokose, Tatsuya Hoshino, Norio Fujiwara, Yoshihiro Murata, Tsuneo Kano, Jun Kojima, Kaoru Sakatani, Yoichi Katayama
Department of Neurological Surgery, Nihon University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 83-83, 2007.

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O2G1-5 Morphine(MOR)up-regulates L-type high voltage-gated calcium channels(HVCCs)through ryanodine receptor activation in mouse brains.

Masashi Katsura, Masahiro Shibasaki, Seitaro Ohkuma
Dept.Pharmacol., Kawasaki Med.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 84-84, 2007.

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O2I1-1 Proteomic identification of peroxiredoxin2 as a novel signaling molecule activated by angiotensin II.

Yoshiko Tokutomi1, Keiichiro Kataoka1, Norie Araki2, Syokei Kim-Mitsuyama1
1Dept.Pharmacol.＆ Mol.Ther., Kumamoto Univ.Grad.Sch.Med.Sci., 2Dept.Tumor Genet.＆ Bio., Kumamoto Univ.Grad.Sch.Med.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 84-84, 2007.

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O2I1-2 Evaluation of sex differences in electrophysiological properties using cynomolgus monkey cardiac muscles

Masaaki Ban, Kiyokazu Yunomae, Akiko Suzuki, Junko Matsuo, Mihori Haruyama, Takahiro Nakamura, Takayuki Sukamoto, Koichiro Fukuzaki, Ryoichi Nagata, Go Kito
Shin Nippon Biomedical Laboratories, Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 84-84, 2007.

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O2I1-3 Mechanisms underlying enhanced cGMP-mediated vasodilator responses to various vasodilator agents following endothelium removal in rat mesenteric resistance arteries.

Yukiko Iwatani1, Saori Atagi1, Hiromi Numa1, Husako Takayama1, Mitsunobu Mio2, Hiromu Kawasaki1
1Dept.Clin.Pharmac.Sci., Grad.Sch.Med.Den.Pharmac.Sci., Okayama Univ., 2Dept.Clin.Pharm.Sch.Pharm., Shujitsu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 84-84, 2007.

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O2I1-4 5-Hydroxytriptamine 2A and 1B receptor-mediated contraction of isolated human internal thoracic artery

Naoko Tanaka1, Masamichi Ohkura1, Eisaku Nakamura2, Masachika Kuwabara2, Yujiro Asada3, Hiroaki Hisa4, Ryuichi Yamamoto1
1First Dept.Pharmacol., Sch.Pharmaceut.Sci., Kyushu Univ.Hlth.Welfare, 2Dept.Cardiovasc.Surg.Miyazaki Pref.Nobeoka Hosp., 3First Dept.Pathol., Miyazaki Med.Coll., Univ., 4Second Dept.Pharmacol., Sch.Pharmaceut.Sci., Kyusyu Univ.Hlth.Welfare
Journal of Pharmacological Sciences 103 (suppl.1) 85-85, 2007.

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O2I1-5 Functional roles of Na+/Ca2+ exchanger on the regulation of Ca2+ activated K+ channels in vascular smooth muscle

Hidemichi Murata1, Hisao Yamamura1, Susumu Ohya1, Takahiro Iwamoto2, Yuji Imaizumi1
1Dept.of Mol.＆ Cell.Pharmacol., Grad.Sch.Pharmaceut.Sci., 2Dept.Pharmacol., Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 85-85, 2007.

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O2E2-1 Lysophosphatidic acid-induced up-regulation of cell surface Nav1.7 Na+ channels in cultured bovine adrenal chromaffin cells

Toyoaki Maruta1, Toshihiko Yanagita1, Kiyotaka Matuo2, Yasuhito Uezono2, Shinya Satoh1, Takayuki Nemoto1, Yoshie Yoshiokawa1, Hiroki Yokoo1, Hideyuki Kobayashi1, Koutarou Taniyama2, Akihiko Wada1
1Dept.Pharmacol., Miyazaki Univ., 2Dept.Pharmacol., Nagasaki Uni.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 85-85, 2007.

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O2E2-2 A transcriptional factor tonicity-response element-binding protein(TonEBP)mediates hypertonicity-induced cytochrome P450 2E1(CYP2E1)upregulation in human hepatocytes

Koko Asakura, Takashi Ito, Katsuhiko Tougou, Tsuyoshi Fukuda, Ryuji Kubota, Yasushi Fujio, Junichi Azuma
Dept.Clin.Pharmacol.and PGx, Grad.Sch.of Pharmceut.Sci., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 85-85, 2007.

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O2E2-3 Novel regulation by Rab-family GTPases of glucose-induced insulin secretion

Toshihide Kimura1, Yukiko Kaneko1, Shogo Yamada1, Akihiro Iwamatsu2, Ichiro Niki1
1Dept.Pharmacol., Oita Univ.Faculty Med., 2Protein Research Network
Journal of Pharmacological Sciences 103 (suppl.1) 86-86, 2007.

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O2E2-4 Role of Na+/Ca2+ exchanger in Ca2+ signaling activated by endothelin-1 in CHO cells stably expressing endothelin type A receptor.

Takahiro Horinouchi, Lingyun Lu, Tadashi Nishiya, Arata Nishimoto, Emi Kajita, Soichi Miwa
Dept.Cellular Pharmacol., Hokkaido Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 86-86, 2007.

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O2F2-1 Calcium cooperativity possibly changes at the motor nerve terminals under chronically exposed to tolerable level of botulinum neurotoxin type A in mice

Ryu Fujikawa, Kimihiro Kato, Toshiaki Ishii, Masakazu Nishimura
Dept.Pathobiological., Obihiro Univ.Sch.Vet
Journal of Pharmacological Sciences 103 (suppl.1) 86-86, 2007.

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O2F2-2 NOX1/NADPH oxidase and the pain signaling

Masakazu Ibi, Kuniharu Matsuno, Chihiro Yabe
Dept.Pharmacol., Kyoto Pref.Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 86-86, 2007.

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O2F2-3 Involvement of peripheral glutamate receptors in nociception.

Fumiko Yamaki1, You-Hong Jin2, Motohide Takemura3, Yoshinobu Takata1, Norifumi Yonehara1
1Dept.Pharmacol.Ohu Univ.Sch.Pharmceu.Sci., 2Dept.Pharmacol.Osaka Univ.Grad.Sch.Dent., 3Dept.Oral Anat.and Neurobiology.Osaka Univ.Grad.Sch.Dent
Journal of Pharmacological Sciences 103 (suppl.1) 87-87, 2007.

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O2G2-1 ATP Attenuation Does Not Account for Apoptosis Induced by Mitochondrial Respiration Chain Inhibitors in Human SH-SY5Y Cells

Masahiko Watabe, Toshio Nakaki
Dept.Pharmacol., Teikyo Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 87-87, 2007.

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O2G2-2 Neuroprotection by antidiarrheic ingredients in cultured hippocampal neurons

Nobuyuki Matsushima1, Nobuaki Moriguchi1, 2, Hitoshi Shibata2, Yuki Kambe2, Noritaka Nakamichi2, Yukio Yoneda2
1Taiko Pharmaceutical Co, Ltd, 2Lab Mol Pharmacol, Kanazawa Univ Grad Sch Nat Sci Tech
Journal of Pharmacological Sciences 103 (suppl.1) 87-87, 2007.

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O2G2-3 Dysfunction of EAAC1 in MPTP-induced mouse model of Parkinson's disease.

Koji Aoyama, Nobuko Matsumura, Masahiko Watabe, Toshio Nakaki
Dept.Pharmacol., Teikyo Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 87-87, 2007.

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O2G2-4 α-1 adrenergic receptor stimulation induces the cell migration of neural progenitor cells in vitro.

Takeshi Hiramoto, Yoshiaki Ihara, Yasuhiro Watanabe
Dept.Pharmacol., Natl.Def.Med.Coll
Journal of Pharmacological Sciences 103 (suppl.1) 88-88, 2007.

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O2G2-5 Functional roles of TRPC receptor-activated Ca2+ channels in astroglia

Aiko Sugishita, Kenji Nakao, Ikkei Matsutani, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Dept.Mol.Pharmacol., Grad.Sch.Phramaceu.Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 88-88, 2007.

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O2I2-1 Jab1, a novel endothelin type A receptor interacting protein, regulates ETAR level and signaling

Arata Nishimoto, Lingyun Lu, Tadashi Nishiya, Takahiro Horinouchi, Emi Kajita, Soichi Miwa
Dept.Cellular Pharmacol., Hokkaido Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 88-88, 2007.

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O2I2-2 Role of nitric oxide(NO)/cGMP/protein kinase G(PKG)pathway in negative regulation of vascular transient receptor potential(TRP)channel TRPC6

Ryuji Inoue, Shinichi Takahashi, Yasuhiro Kawarabayashi, Lin Hai, Akira Honda
Dept.Physiol., Sch.Med.Fukuoka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 88-88, 2007.

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O2I2-3 Imaging cellular Ca2+ signals in the heart in vivo

Junichi Nakai1, Masamichi Ohkura2, Keiji Imoto3, Yvonne.N.Tallini4, Bum-Rak Choi5, Guangju Ji4, Robert Doran4, Jane Lee4, Patricia Plan5, Jason Wilson4, Hong-Bo Xin4, Atsush Sanbe6, James Gulick6, John Mathai5, Jeffrey Robbins6, Guy Salama5, Michael.I.Kotlikoff4
1RIKEN, BSI, Lab for memory and learning, 2Kyushu Univ.of Health and Welfare, 3Dept.of Information Physiol., NIPS, 4Cornell Univ., 5Univ.of Pittsburgh, 6Cincinnati Children s Hospital
Journal of Pharmacological Sciences 103 (suppl.1) 89-89, 2007.

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O2I2-4 Atorvastatin Suppresses the ASK1-Apoptosis Pathway.

Keiichiro Kataoka, Yoshiko Tokutomi, Eiichiro Yamamoto, Tatsuro Yamashita, Shinji Matsuba, Taishi Nakamura, Yifei Dong, Zhong-Fang Lai, Shokei Kim-Mitsuyama
Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University
Journal of Pharmacological Sciences 103 (suppl.1) 89-89, 2007.

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O2I2-5 A mechanism underlying the induction of an early afterdepolarization by L-type Ca2+ channels

Mitsuhiko Yamada, Natsuko Tsujino
Dept.Mol.Pharmacol., Shinshu Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 89-89, 2007.

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O2E3-1 Possible intracellular source of ATP released by bradykinin from cultured smooth muscle cells.

Takeshi Katsuragi1, Yumei Zhao1, Chiemi Sato1, Sadaharu Usune2, Masaru Segawa3, Takahiro Iwamoto1, Keisuke Migita1
1Dept.Pharmacol., Sch.Med., Fukuoka Univ., 2Res.Lab.Biodynam., Sch.Med., Fukuoka Univ., 3Cent.Lab.Pathol.Morphol., Sch.Med., Fukuoka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 89-89, 2007.

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O2E3-2 Identification of the binding protein for a neutral amino acid transporter B0AT1 related to Hartnup disorder that controls its apical sorting.

Naohiko Anzai1, Taku Hirata1, Akio Koizumi2, Yoshikatsu Kanai1
1Dept.Pharmacol.Toxicol., Kyorin Univ.Sch.Med., 2Dept Health Environ Sci, Kyoto Univ Grad Sch Med
Journal of Pharmacological Sciences 103 (suppl.1) 90-90, 2007.

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O2E3-3 Glycogen synthase kinase-3β:regulation of insulin signaling molecules in adrenal chromaffin cells

Takayuki Nemoto, Hiroki Yokoo, Shinya Satoh, Toshihiko Yanagita, Norie Yoshikawa, Toyoaki Maruta, Hideyuki Kobayashi, Akihiko Wada
Dept.Pharmacol., Miyazaki Med.Coll., Univ
Journal of Pharmacological Sciences 103 (suppl.1) 90-90, 2007.

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O2E3-4 The roles of Ca2+ and IP3 in clustering of GFP-tagged IP3 receptors in cultured cells

Yosuke Tojyo, Akihiko Tanimura, Takao Morita
Dept.Dent.Pharmacol., Sch.Dent., Health Sci.Univ.Hokkaido
Journal of Pharmacological Sciences 103 (suppl.1) 90-90, 2007.

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O2F3-1 Effect of nicotine on IL-18-initiated immune response in human monocytes

Hideo Takahashi, Toru kanke, Keyue Liu, Masahiro Nishibori
Dept.Pharmacol., Okayama Univ.Grad.Sch.Med., Dent ＆ Pharm Shikata-cho, 2-5-1
Journal of Pharmacological Sciences 103 (suppl.1) 90-90, 2007.

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O2F3-2 Regulation of late asthmatic response(LAR)by endogenously produced interleukin(IL)-10 in a murine model of asthma

Takeshi Nabe, Nobuaki Mizutani, Masanori Fujii, Shigekatsu Kohno
Dept.Pharmacol., Kyoto Pharm.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 91-91, 2007.

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O2F3-3 Early treatment of antihistamines suppresses toluene 2, 4-diisocyanate-induced histamine H1, receptor and interleukin-4 mRNA elevation in allergy model rats.

Masaya Hatano1, Chiyo Matsushita1, Masum Shahriar1, Wakana Kuroda2, Yoshiaki Kitamura2, Asish K.Das1, Shrabanti Dev1, Hiroyuki Mizuguchi1, Noriaki Takeda2, Hiroyuki Fukui1
1Dept.Molecular Pharmacol., Tokushima Univ.Institute of Health Bioscience, 2Dept.Molecular Otolaryngol, Tokushima Univ.Institute of Health Bioscience
Journal of Pharmacological Sciences 103 (suppl.1) 91-91, 2007.

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O2F3-4 Stimulation of α7 nicotinic acetylcholine receptor inhibits CD14 and the toll like receptor-4 expression on human monocytes

Ryosuke Hamano1, Hideo Takahashi2, Hiromi Iwagaki1, Noriaki Tanaka1, Masahiro Nishibori2
1Dept.Gastroenterological Surge., Grad.Sch.Med., Okayama Univ, 2Dept.Pharmacol., Grad.Sch.Med., Okayama Univ
Journal of Pharmacological Sciences 103 (suppl.1) 91-91, 2007.

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O2F3-5 Establishment of mycophenolate mofetil(MMF)monitoring by pharmacodynamic analysis

Yoko Kurata1, 2, Takafumi Kuzuya2, Takaaki Kobayashi3, Yuko Miwa3, Yukari Waki1, Kazuharu Uchida4, Akimasa Nakao3, Yukihiro Noda1, 2, Toshitaka Nabeshima2
1Divi.Clin.Sci.Neuropsychopharmacol., Fac.Pharm., Meijo Univ., 2Dept.Neuropsychopharmacol.Hosp.Pharm., Nagoya Univ.Grad.Sch.Med., 3Dept.Surg.II Nagoya Univ.Grad.Sch.Med., 4Dept.Transplant Endocri.Surg., Nagoya Daini Red Cross Hosp
Journal of Pharmacological Sciences 103 (suppl.1) 91-91, 2007.

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O2G3-1 Impairment of memory function in neural junctophilin deficient mice

Shigeki Moriguchi1, Miyuki Nishi2, Hiromu Yawo3, Hiroshi Takeshima2, Kohji Fukunaga1
1Dept.Pharmacol., Grad.Sch.Pharmaceut. Sci., Tohoku Univ., 2Dept.Biol.Chem., Grad.Sch.Pharmaceut.Sci., Kyoto Univ., 3Dept.Dev.Biol.Neurosci., Grad.Sch.Life Sci., Tohoku Univ
Journal of Pharmacological Sciences 103 (suppl.1) 92-92, 2007.

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O2G3-2 TRPV1 channels mediate vanilloids and low pH-induced neuronal death in rat cortical cultures

Hisashi Shirakawa, Tomoko Yamaoka, Takayuki Nakagawa, Shuji Kaneko
Dept.Mol.Pharmacol, Grad.Sch.Pharmaceu.Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 92-92, 2007.

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O2G3-3 Serotonin(5-HT)-induced glial cell line-derived neurotrophic facto (GDNF)expression is mediated by Src family-dependent fibroblast growth factor receptor(FGFR)transactivation in C6 glioma cells.

Mami Tsuchioka1, 2, Minoru Takebayashi1, 3, Kazue Hisaoka1, Toshinori Uike1, Yoshihiro Nakata2
1Inst.Clin.Res., NHO, Kure Medical Center and Chugoku Cancer Center, 2Dept.Pharmacol., Hiroshima Univ., 3Dept.Psychiat., NHO, Kure Medical Center and Chugoku Cancer Center
Journal of Pharmacological Sciences 103 (suppl.1) 92-92, 2007.

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O2G3-4 ER stress-responsible pathway distinct in SK-N-SH and SH-SY5Y cells.

Yasuhiro Kosuge, Tetsuro Oda, Kumiko Ishige, Yoshihisa Ito
Res.Unit of Pharmacol., Dept of Clin.Pharm., Coll.of Pharm., Nihon Univ
Journal of Pharmacological Sciences 103 (suppl.1) 92-92, 2007.

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O2G3-5 Activation of P2X7 receptor suppresses the transport of glutamate in cultured spinal microglia

Norimitsu Morioka, Joynal Abdin, Tomoya Kitayama, Katsuya Morita, Toshihiro Dohi
Dept.Dent.Pharmacol.Hiroshima Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 93-93, 2007.

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O2I3-1 Fluorescence imaging analysis of mitochondrial Ca2+ dynamics in permeabilized H9c2 cells

Iyuki Namekata1, Toru Kawanishi2, Naoko Iida-Tanaka3, Hikaru Tanaka1, Koki Shigenobu1
1Dept.Pharmacol., Toho Univ.Sch.Pharmaceutical.Sci., 2Div.Drugs, Natl.Inst.Health Sci., 3Dept.Food Sci., Otsuma Woman's Univ
Journal of Pharmacological Sciences 103 (suppl.1) 93-93, 2007.

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O2I3-2 Differential effects of resveratrol tetramers from Vitis coignetiae on cardiomyocyte apoptosis in adult rat

Kazuhiko Seya1, Ken-Ichi Furukawa1, Kouta Kanemaru1, Chiharu Sugimoto2, Megumi Suzuki3, Teruko Takeo3, Shigeru Motomura1, Haruo Kitahara2, Masatake Niwa4, Yoshiteru Oshima5
1Dept.Pharmacol., Hirosaki Univ.Sch.Med., 2Fac.Edu., Hirosaki Univ., 3Hirosaki Univ.Sch.Health Sci., 4Fac.Pharm., Meijo Univ., 5Grad.Sch.Pharmaceut.Sci., Tohoku Univ
Journal of Pharmacological Sciences 103 (suppl.1) 93-93, 2007.

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O2I3-3 Ionic mechanisms underlying the positive chronotropic action of PGF2αa and TXA PGF2 in isolated guinea-pig sinoatrial node cells.

Kyoichi Ono1, Susumu Fujisawa1, Koh-ichi Yuhki2, Fumitaka Ushikubi2, Toshihiko Iijima1
1Dept.Pharmacol., Akita Univ.Sch.Med., 2Dept.Pharmacol., Asahikawa Med.Coll
Journal of Pharmacological Sciences 103 (suppl.1) 93-93, 2007.

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O2I3-4 DAHP decreases cytokine-induced increase in VCAM-1 levels on the cell surface of HUVEC by BH4-independent mechanism

Kazuhisa Ikemoto1, Takashi Matsumoto2, Asaka Akita1, Chiho Ichinose1, Takahide Nomura1
1Dept.Pharmacol., Fujita Health Univ.Sch.Med., 2Dept.Int.Med., Fujita Health Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 94-94, 2007.

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O2I3-5 Ephrin-B1 and Its Cognate Receptor EphB2 Are Expressed on Normal Adult Arterial Endothelium and Both Inhibit Monocyte Chemotaxis:New Molecular Insight into Atherogenesis

Aiji Sakamoto1, Hatsue Ueda2, Tsuyoshi Yoshimuta1, Yuka Sugamoto1, Masakazu Yamagishi3
1Div.Biotech., Natl.Cardiovasc.Ctr., 2Div.Pathol., Natl.Cardiovasc.Ctr., 3Div.Cardiovasc., Kanazawa Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 94-94, 2007.

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O2E4-1 Decision of stabilization or degradation of Chronic myelogenous leukemia(CML)oncoprotein, BCR-ABL, via kinase domain

Fujiko Tsukahara, Yoshiro Maru
Dept.Pharmacol., Tokyo Women's Med.Univ., Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 94-94, 2007.

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O2E4-2 Snapin augments α 1A-adrenoceptor-operated calcium influx through TRPC6

Fumiko Suzuki, Shigeru Morishima, Takashi Tanaka, Ikunobu Muramatsu
Div.Pharmacology, Univ.Fukui Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 94-94, 2007.

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O2E4-3 Distinct subcellular expressions of post-translationally modified Ca2+-activated CI- channel-related molecules

Jun Yamazaki1, Kazuhiko Okamura2, Kenji Kitamura1
1Dept.Physiol.Sci ＆ Mol.Biol., Fukuoka Dent.Coll., 2Dept.Morphol.Biol., Fukuoka Dent.Coll
Journal of Pharmacological Sciences 103 (suppl.1) 95-95, 2007.

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O2F4-1 Increase in extracellular ATP hydrolysis by prostaglandin E2 in murine J774 macrophages

Isao Matsuoka, Masa-aki Ito
Laboratory of Pharmacology, Takasaki University of Health and Welfare
Journal of Pharmacological Sciences 103 (suppl.1) 95-95, 2007.

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O2F4-2 Inhibition of macrophage activation and induction of apoptosis by EGCG or autophagy inhibitors.

Ken Hashimoto, Hiroshi Sakagami
Div.Pharmacol., Meikai Univ.Sch.Dent
Journal of Pharmacological Sciences 103 (suppl.1) 95-95, 2007.

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O2F4-3 A regulated adaptor function of p40phox:a head-to-tail(PX-PB1 domain)intramolecular interaction of p40phox in its resting state

Takehiko Ueyama1, Toshihiko Tatsuno1, Takumi Kawasaki1, Satosi Tsujibe1, Yasuhito Shirai1, Hideki Sumimoto2, Thomas.L.Leto3, Naoaki Saito1
1Molecular Pharmacology, Biosignal Research Center, Kobe Univ., 2Medical Institute of Bioregulation Kyusyu Univ., 3Molecular Defenses Section, LHD/NIAID/NIH
Journal of Pharmacological Sciences 103 (suppl.1) 95-95, 2007.

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O2F4-4 Effects of Na+/H+ Exchanger Inhibitor on the Lipopolysaccharide-induced Prostaglandin E2 Production and Inflammation

Fumitaka Kamachi1, Hyun Seung Ban1, Noriyasu Hirasawa1, Kazuo Ohuchi1, 2
1Lab.of Pathophysiol.Biochem, , Grad.Sch.of Pharm.Sci., Tohoku Univ., 2Yasuda Women's Univ
Journal of Pharmacological Sciences 103 (suppl.1) 96-96, 2007.

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O2G4-1 Development of a high-throughput method to generate a high performance optical glutamate indicator

Sho Iinuma, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose
Dept.Cell Physiol., Nagoya Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 96-96, 2007.

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O2G4-2 The excess membrane hyperpolarization induced by Kir2.1 activation causes brain capillary endothelial cell death

Daiju Yamazaki1, Hisao Yamamura1, Susumu Ohya1, Katsuhiko Muraki2, Kiyofumi Asai3, Yuji Imaizumi1
1Dept.Mol.＆ Cell.Pharmacol., Grad.Sch.of Pharmaceut.Sci., Nagoya City Univ., 2Cell.Pharmacol., Sch.of Pharm., Aichi gakuin Univ., 3Dept.of Mol.Neurobiol., Grad.Sch.of Med.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 103 (suppl.1) 96-96, 2007.

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O2G4-3 Endothelial regulation on neuronal damage via astrocytes

Takako Takemiya1, 2, Kiyoshi Matsumura3, Michiyo Maehara4, Hiroko Sugiura2, Shin Yasuda2, Satoshi Uematsu5, Shizuo Akira5, Kanato Yamagata2
1Medical Research Institute, Tokyo Women's Medical Univ.Sch.Med, 2Dept.Neuropharmaco., Tokyo Metro.Insti.Neurosci., 3Information Sci.and Technol., Osaka Inst.Technol., 4Cent.Clin.Lab., Tokyo Women's Medical Univ., 5Dept.of Host Defense, Res.Insti.for Microbial Dis., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 96-96, 2007.

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O2G4-4 Neurotensin receptor type-1 impair the LTP gated by dopamine D2 receptor in the basolateral amygdala

Taiju Amano1, 2, Etsuko Wada1, 3, Mami Noda2, Keiji Wada1, 3, Masayuki Sekiguchi1, 3
1Dept.Degenerat.Neurol.Dis., NCNP, 2Lab.Pathophysiol., Grad.Sch.Pharm.Sci., Kyushu Univ., 3CREST
Journal of Pharmacological Sciences 103 (suppl.1) 97-97, 2007.

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O2G4-5 Desensitization of GABAB receptor signaling by formation of protein complexes of GABAB2 subunit with GRK4 or GRK5.

Yasuhito Uezono1, Masato Kanaide1, 2, Minoru Hojo1, 2, Yuko Ando1, 2, Yuka Sudo1, Koji Sumikawa2, Kohtaro Taniyama1
1Dept.Pharmacol., Nagasaki Univ.Grad.Sch.Biomed.Sci., 2Dept.Anesth., Nagasaki Univ.Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 97-97, 2007.

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O2I4-1 Radical scavenging effect of the photodegradation product of nifedipine

Yuya Horinouchi1, Koichiro Tsuchiya1, Hideki Ohnishi2, Soichiro Tajima2, 3, Chiaki Taoka1, Yasuhisa Kanematsu2, Yoshiharu Takiguchi1, Toshiaki Tamaki2
1Dept.Clin.Pharmacol., Inst.HBS, Univ.Tokushima Grad.Sch., 2Dept.Pharmacol., Inst.HBS, Univ.Tokushima Grad.Sch., 3Dept.Pharmacy, Tokushima Univ.Hosp
Journal of Pharmacological Sciences 103 (suppl.1) 97-97, 2007.

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O2I4-2 Cell-protective effects of nifedipine metabolite in HGEC

Yayoi Fukuhara1, Koichiro Tsuchiya2, Yuya Horinouchi2, Chiaki Taoka2, Sakiko Orino1, Ken-ichi Chikutei1, Yuki Motobayashi1, Yasuhisa Kanematsu1, Keisuke Ishizawa1, Toshiaki Tamaki1
1Dept.Pharmacol., Inst.HBS, Univ.Tokushima Grad.Sch., 2Dept.Clin.Pharmacol., Inst.HBS, Univ.Tokushima Grad.Sch
Journal of Pharmacological Sciences 103 (suppl.1) 97-97, 2007.

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O2I4-3 Analysis of the membrane currents in single atrial myocytes from septic guinea pigs.

Noboru Hatakeyama, Naoyuki Matsuda, Mitsuaki Yamazaki, Yuichi Hattori
Depts.of Mol.＆ Med.Pharmacol.and Anesthesiol., Graduate Sch.of Med.＆ Pharm.Sci., Univ.of Toyama
Journal of Pharmacological Sciences 103 (suppl.1) 98-98, 2007.

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O2I4-4 Rac 1 activity is required for cardiac myocyte alignment in response to mechanical stress

Masako Yamane, Takahisa Matsuda, Takashi Ito, Yasushi Fujio, Kyoko Takahashi, Junichi Azuma
Dept.Clin.Pharmacol.and PGx, Grad.Sch.of Pharmaceut.Sci., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 98-98, 2007.

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O2I4-5 Spontaneous Ca2+ transients from sarcoplasmic reticulum and mitochondria in P19CL6 cells

Yuko Hori, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept.Mol.＆ Cell.Pharmacol., Grad.Sch.Pharmaceut.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 103 (suppl.1) 98-98, 2007.

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O2F5-1 Can Muscarinic Receptor Antagonists Increase Urine Storing Function Without Reducing Voiding Function?

Masato Nanri, Tomoko Yamato, Hukumitu Sakakibara, Yumi Kuwata, Tsukasa Kirimoto, Mamoru Kiniwa, Toshinori Oka
Taiho Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 98-98, 2007.

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O2F5-2 Preventive mechanisms of agmatine against ischemic acute renal failure in rats

Takahiro Sugiura1, Masanori Takaoka1, Shuhei Kobuchi1, Hidenobu Tsutsui2, Toshihide Fujii1, Kentaro Hayashi1, Yasuo Matsumura1
1Dept.Pharmacol., Osaka Univ.Pharmaceut.Sci., 2Lab.Clin.Pharmacol., Fac.Pharm., Osaka Ohtani Univ
Journal of Pharmacological Sciences 103 (suppl.1) 99-99, 2007.

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O2F5-3 Sex difference in ischemic acute renal failure:approach by proteomic analysis

Junji Takayama, Masanori Takaoka, Youko Sugino, Yuji Yamamoto, Aiko Satake, Yasuo Matsumura
Dept.Pharmacol., Osaka Univ.Pharmaceut.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 99-99, 2007.

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O2F5-4 Telmisartan Prevents the Progression of Podocyte Abnormality in Type 2 Diabetic Rats with Microalbuminuria

Akira Nishiyama1, Yukiko Nagai1, Yoshio Konishi2, Masahito Imanishi2
1Dept.Pharmacol., Kagawa Univ.Med.Sch., 2Dept.Internal Med., Osaka City General Hosp., Department of Internal Medicine, Osaka City General Hospital
Journal of Pharmacological Sciences 103 (suppl.1) 99-99, 2007.

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O2F5-5 Subtle renal dysfunction and augmentation of renal ischemia/reperfusion injury in heterozygous NCX2-deficient mice

Ayako Furuta1, 2, Satomi Kita1, Takeshi Katsuragi1, Yukio Takano2, Yuji Arai3, Takahiro Iwamoto1
1Dept.Pharmacol., Sch.Med., Fukuoka Univ., 2Dept.Physiol.Pharmacol., Facul.Pharmaceu.Sci., Fukuoka Univ., 3Bioscience, Natl.Cardiovasc.Ctr.Res.Insti
Journal of Pharmacological Sciences 103 (suppl.1) 99-99, 2007.

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O2F5-6 Effect of preconditioning on ischemia-reperfusion injury in the rat bladder

Yoshie Hisadome, Motoaki Saito, Tomoharu Kono, Emi Kazuyama, Takuya Hanada, Yukako Kinoshita, Itaru Satoh, Keisuke Satoh
Div.Mol.Pharmacol., Tottori Univ.Faculty Med
Journal of Pharmacological Sciences 103 (suppl.1) 100-100, 2007.

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O2G5-1 The hyperexcitability-induced upregulation of cAMP level disturbs normal hippocampal mossy fiber projections.

Rieko Muramatsu, Yuji Ikegaya, Norio Matsuki, Ryuta Koyama
Lab.Chem.Pharmacol., Grad.Sch.Pharm.Sci., The Univ.Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 100-100, 2007.

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O2G5-2 Molecular mechanism underlying P2X4 receptor upregulation in microglia by fibronectin

Emika Toyomitsu, Makoto Tsuda, Kazuhide Inoue
Dept.Mol.Syst.Pharmacol., Grad.Sch.Pharm.Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 100-100, 2007.

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O2G5-3 Increase of AMPA-mediated mEPSC amplitude induced by chronic treatment with AP5 in cultured hippocampal neurons

Kenichi Kato1, Tomoaki Shirao2, Hideto Takahashi2, Yuko Sekino1, 2, 3
1CREST, JST, 2Dept Neurobiol ＆ Behav, Gunma Univ.Grad.Sch.Med., 3Div of Neuronal Network, Ins of Med Sci, Univ of Tokyo
Journal of Pharmacological Sciences 103 (suppl.1) 100-100, 2007.

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O2G5-4 Lithium-induced inhibition of Na+ channel activity and up-regulation of cell surface Na+ channel expression

Toshihiko Yanagita1, Toyoaki Maruta1, Yasuhito Uezono2, Kiyotaka Matsuo2, Shinya Satoh1, Hiroki Yokoo1, TakaYuki Nemoto1, Norie Yoshikawa1, Hideyuki Kobayashi1, Akihiko Wada1
1Dept.Pharmacol., Miyazaki Med.Coll., Univ.Miyazaki, 2Dept.Pharmacol., Nagasaki Univ., Grad.Sch.Biomed.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 101-101, 2007.

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O2G5-5 Development of intracellular muscarinic receptor in rat cerebral cortex and hippocampus

Abu Syed MD Anisuzzaman, Shigeru Morishima, Fumiko Suzuki, Takashi Tanaka, Ikunobu Muramatsu
Div.Pharmacology, Univ.Fukui Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 101-101, 2007.

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O2I5-1 Laminar shear stress-induced aryl hydrocarbon receptor is involved in CYP1A1 activation and cell cycle inhibition in vascular endothelial cells

Yoshikazu Miwa, Zhiyi Han, Toshiyuki Sasaguri
Dept.Clin.Pharmacol., Kyushu Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 101-101, 2007.

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O2I5-2 Inhibition of cytochrome c release by 10-N-nonyl acridine orange during myocardial ischemia/reperfusion in rats

Guo-xing Zhang1, Yukiko Nagai2, Akira Nishiyama1, Yoshihide Fujisawa2, Shoji Kimura1
1Dep.Pharmacol., Kagawa Univ.Med.Sch., 2Life Sci.Center, Kagawa Univ
Journal of Pharmacological Sciences 103 (suppl.1) 101-101, 2007.

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O2I5-3 Oxytocin potentiates the opening of mitochondrial ATP-sensitive K+ channels and reduces infarct size in rabbit hearts

Hirofumi Nishida1, 2, Toshiaki Sato1, Mika Fukasawa1, Masaru Miyazaki2, Haruaki Nakaya1
1Dept.Pharmacol., Chiba Univ.Grad.Sch.Med., 2Dept.General Surg., Chiba Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 102-102, 2007.

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O2I5-4 Activation of HtrA2, a mitochondrial serine protease mediates myocardial ischemia/reperfusion injury in rat heart

Bhuiyan Md.Shenuarin1, Kohji Fukunaga1, 2
1Dept.Pharmacol.Tohoku Univ.Grad.Sch.Pharm.Sci., 2Tohoku Univ.21st Century COE Program CRESCENDO
Journal of Pharmacological Sciences 103 (suppl.1) 102-102, 2007.

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O2I5-5 Search for cardiomyogenesis marker genes in multipotent cells.

Yoji Sato1, Tetsuya Hasegawa1, 2, Tetsuji Hosono1, Mitsutoshi Satoh2, Teruhide Yamaguchi3
1Div.Cell.Gene Thpy.Prod., NIHS, 2Dept.Drug Safety, Faculty Pharmaceutical Sci., Toho Univ., 3Div.Biol.Chem.Biologicals, NIHS
Journal of Pharmacological Sciences 103 (suppl.1) 102-102, 2007.

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O2G6-1 Colocalization of Pur α with 36 kDa heterogeneous nuclear ribonuclear protein(hnRNP)A2/B1, Pur α-binding protein, in RNA-transport granules.

Che-Hui Kuo
Dept.Pharmacol, Osaka Univ.Med.Sch
Journal of Pharmacological Sciences 103 (suppl.1) 102-102, 2007.

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O2G6-2 Functional analysis of brain synaptic transmission after in vivo gene silencing of presynaptic protein in the rat primary afferent ganglion

Chiaki Yamada1, 2, Eiji Shigetomi1, 3, Takeshi Suzuki2, Fusao Kato1
1Lab.Neurophysiol., Dept.Neurosci., Jikei Univ.Sch.Med., 2Dept.Basic.Biol.Sci, 3JSPS
Journal of Pharmacological Sciences 103 (suppl.1) 103-103, 2007.

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O2G6-3 Molecular functions of histone deacetylase SIRT1 in neural differentiation

Shin Hisahara1, 4, Susumu Chiba2, 4, Hiroyuki Matsumoto3, 4, Shun Shimohama4, Yoshiyuki Horio1
1Dept.Pahrmacol., Sapporo Med.Univ., Sch.Med., 2Dept.Neurol., Sapporo Yamano-ue Hosp., 3Faculty of Human Sci., Hokkaido Bunkyo Univ., 4Dept.Neural., Sapporo Med.Univ., Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 103-103, 2007.

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O2G6-4 Identification of novel lead compounds for UCH-L3 inhibitor by virtual screening

Kazunori Hirayama1, 2, Syunsuke Aoki1, Takashi Matsumoto2, Keiji Wada3
1Third laboratory, Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Japan, 2Dept.of Electr.Eng.＆ Bioscience, Waseda Univ., Tokyo, Japan, 3Department of Degenerative Neurological Diseases, National Institute of Neuroscience, NCNP, Japan
Journal of Pharmacological Sciences 103 (suppl.1) 103-103, 2007.

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O2G6-5 The anxiogenic effect of corticotropin releasing factor in the median raphe nucleus

Yu Ohmura, Taku Yamaguchi, Takeshi Izumi, Machiko Matsumoto, Mitsuhiro Yoshioka
Dept.Neuropharmacology., Hokkaido Univ.Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 103-103, 2007.

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O3E1-1 Involvements of Rho-kinase and protein kinase C in stretch-induced triphosphorylation of myosin light chain in canine basilar artery

Kazuo Obara, Yoshihiko Ito, Hiroki Shimada, Koichi Nakayama, Tomohisa Ishikawa
Dept.Cell Mol.Pharmacol., Grad.Sch.Pharmaceut.Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 103 (suppl.1) 104-104, 2007.

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O3E1-2 Synergistic activation of receptor-operated cationic channels by M2 and M3 muscarinic receptors in mouse ileal smooth muscle cells.

Takashi Sakamoto1, Toshihiro Unno2, Hayato Matsuyama2, Takio Kitazawa3, Tetsuro Taneike3, Masahisa Yamada4, Wess Jurgen5, Seiichi Komori2
1Dept.Patho Vet Sci., Gifu Univ.Unite Grad Sch Vet Sci, 2Lab.Pharmacol., Dept.Vet.Med., Gifu Univ., 3Dept.Pharmacol., Fac.Vet.Med., Rakuno Gakuen Univ., 4Lab.Neurogenetics, Brain Sci Inst., RIKEN, 5Lab Bioorganic Chem., NIH-NIDDK
Journal of Pharmacological Sciences 103 (suppl.1) 104-104, 2007.

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O3E1-3 Alteration of glucose-dependent contractility in spontaneously hypertensive and hyperlipidemic rat(SHHR)bladder

Koji Nobe1, Taigi Yamazaki1, Toshio Kumai2, Masako Okazaki3, Shinichi Iwai3, Shinichi Kobayashi2, Katsuji Oguchi3, Kazuo Honda1
1Dept.Pharmacol., Showa Univ.Sch.Pharm., 2Dept.Pharmacol., St.Marianna Univ.Sch.Med., 3Dept.Pharmacol., Showa Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 104-104, 2007.

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O3E1-4 Biophysiological and molecular properties of voltage-gated Na+ channels in murine vas deferens

Noriyoshi Teramoto, Hai-Lei Zhu, Manami Aishima, Yushi Ito
Dept.Pharmacol., Kyushu Univ., Gradutate Sch.Med.Sciences
Journal of Pharmacological Sciences 103 (suppl.1) 104-104, 2007.

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O3E1-5 Disruption of taurine transporter gene results in the decrease of exercise capacity and skeletal muscle atrophy in mice.

Yasushi Kimura, Takashi Ito, Yoriko Uozumi, Mika Takai, Takahito Ito, Yasushi Fujio, Junichi Azuma
Dept.Clin.Pharmacol.and PGx, Grad.Sch.of Pharmceut.Sci., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 105-105, 2007.

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O3F1-1 Possible role of a TRPV6 haplotype in selective adanvantage in non-African populations by its plausible increased calcium permeability

Yuka Sudo1, Yasuhito Uezono1, Kiyotaka Matsuo1, Mikiko Soejima2, Yoshiro Koda2
1Dept.Pharmacol., Nagasaki Univ.Grad.Sch.Biomed.Sci., 2Dept.Foren.Med.＆ Hum.Genet. Kurume Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 105-105, 2007.

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O3F1-2 Transcriptional activation of histone deacetylase SIRT1 by Notch1 signal

Yoshiyuki Horio1, Umefumi Iguchi1, Takafumi Ninomiya2, Haruyuki Tatsumi2, Shin Hisahara1, Masaya Tanno1, Haruo Takemura1
1Dept.Pharmacol., Sapporo Med.Univ., 2Dept.Anatomy I, Sapporo med.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 105-105, 2007.

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O3F1-3 Existence and Characterization of beta-Defensins in Rat Salivary Glands

Takashi Shinomiya1, Mitsuru Kawaguchi1, Masanobu Yoshikawa1, 2, Takayuki Sakai1, Yasuhiro Kosuge3
1Dept.Pharmacol., Tokyo Dent.Col., 2Dept.Clin.Pharmacol., Tokai Univ.Sch.Med., 3Dept.Pharmacol., Col.Pharm., Nihon Univ
Journal of Pharmacological Sciences 103 (suppl.1) 105-105, 2007.

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O3G1-1 Basal nucleus of amygdala plays essential role in expression of conditioned fear stress

Takeshi Izumi1, 2, Shinmin Weng1, Takeshi Inoue1, Akiko Kato1, Shin Nakagawa1, Taku Yamaguchi2, Machiko Matsumoto2, Misuhiro Yoshioka2, Tsukasa Koyama2
1Dept.Psychiatry, Hokkaido Univ.Sch.Med., 2Dept.Neuropharmacology, Hokkaido Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 106-106, 2007.

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O3G1-2 Effects of cholinergic drugs on hippocampal theta activity during radial maze performance in rats

Takayoshi Masuoka, Masa Yasuda, Chiaki Kamei
Depart.Med.Pharmacol., Okayama Univ.Grad.Sch.Med., Dent.＆ Pharm.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 106-106, 2007.

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O3G1-3 Kampo formula Kihi-to improves memory disorder in Alzheimer's disease model mice by calpain inhibition

Rie Naito, Chihiro Tohda, Takako Yokozawa
Div.of Biofunctional Evalution, Res.Center for Ethnomed., Inst.of Natural Med., Univ.of Toyama
Journal of Pharmacological Sciences 103 (suppl.1) 106-106, 2007.

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O3G1-4 4 dimensional analysis of exocytotic events and vesicle movements in chromaffin cells by LSM-5Live system.

Mitsunori Hayashi, Mizuki Sekiguchi, Fuyuka Matsuda, Nobuyuki Sasakawa, Konosuke Kumakura
Life Science Institute, Sophia Univ
Journal of Pharmacological Sciences 103 (suppl.1) 106-106, 2007.

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O3G1-5 Antidepressants inhibit P2X4R function:a possible mechanism of neuropathic pain relief

Kenichiro Nagata, MAKOTO TSUDA, KAZUHIDE INOUE
Dept.Mol.Syst.Pharmacol., Grad.Sch.Pharm.Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 107-107, 2007.

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O3H1-1 Signal cascade for NO-induced apoptosis and its prevention by the specific inhibitor of Na+-Ca2+ exchanger SEA0400

Tatsuya Kitao1, Katsuhiro Nakagawa1, Aki Ikehara1, Hiroko Fujisaki1, Yukio Ago1, Akemichi Baba2, Toshio Matsuda1, 3
1Lab.Medicinal Pharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 2Lab.Mol.Neuropharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 3Center for Child Mental Dev., Grad.Sch.Med., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 107-107, 2007.

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O3H1-2 PRIP facilitates trafficking of γ 2 subunit-containing GABAA receptor to cell-surface

Masato Hirata, Takashi Kanematsu, Akiko Mizokami
Lab.Biochem.Fac.Dent.Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 107-107, 2007.

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O3H1-3 Effects of glucose on the cognitive behaviors in mice:Involvement of aFGF in the prefrontal cortex.

Takayoshi Mamiya, Makoto Ukai
Dept.Chem Pharmacol., Fac.Pharm., Meijo Univ
Journal of Pharmacological Sciences 103 (suppl.1) 107-107, 2007.

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O3H1-4 The role of p38 in epilepsy

Kana Namiki1, 6, Akira Nakamura2, Mitsuko Furuya3, Yuji Matsuo1, Naoki Tokuhara1, Tatsuhiko Sudo4, Hiroshi Hama4, Tomoyuki Kuwaki2, Akiyoshi Fukamizu5, Shingo Yano6, Sadao Kimura1, Yoshitoshi Kasuya1
1Dept.Biochem.Mol.Pharmacol., Chiba Univ.Sch.Med, 2Dept.Auto.Physiol., 3Chiba, 4RIKEN, 5TARA cent, Tsukuba Univ., 6Dept.Mol.Pharmacol.Pharmather
Journal of Pharmacological Sciences 103 (suppl.1) 108-108, 2007.

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O3I1-1 Involvement of the ATF-1-MEF2B cascade in the expression of NOX1/NADPH oxidase in vascular smooth muscle cells

Masato Katsuyama, Noriaki Arakawa, Chihiro Yabe-Nishimura
Dept.Pharmacol., Kyoto Pref.Univ.Med
Journal of Pharmacological Sciences 103 (suppl.1) 108-108, 2007.

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O3I1-2 P2Y12 receptor contributes to the development of allo-transplant arteriosclerosis in the carotid artery and to the prolongation of heart allo-graft survival.

Kenichi Yashiro, Yuji Matsumoto, Yasuhiro Suzuki, Kazunao Kondo, Kazuo Umemura
Dept.Pharmacol., Hamamatsu Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 108-108, 2007.

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O3I1-3 Role of Chymase and Matrix Metalloproteases in Angiotensin II-Induced Aortic Aneurysms in mice

Nao Inoue1, 2, Michiko Muramatsu1, Denan Jin1, Shinji Takai1, Tetsuya Hayashi3, Hiroshi Katayama2, Yasushi Kitaura3, Hiroshi Tamai2, Mizuo Miyazaki1
1Dept.of Pharmacol., Osaka Medical College, 2Dept.of Pediatrics, Osaka Medical College, 3Dept.of Internal Medicine(III)
Journal of Pharmacological Sciences 103 (suppl.1) 108-108, 2007.

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O3I1-4 New predictive marker for proarrhythmic potential of drugs assessed in the canine chronic atrioventricular block model.

Akira Takahara, Yuji Nakamura, Atsushi Sugiyama
Dept.Pharmacol., Univ.of Yamanashi
Journal of Pharmacological Sciences 103 (suppl.1) 109-109, 2007.

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O3I1-5 Taurine depletion leads to the impaired mitochondrial function and cardiomyopathy in mice

Takashi Ito, Yasushi Fujio, Yoriko Uozumi, Yasushi Kimura, Mika Takai, Junichi Azuma
Dept.Clin.Pharmacol.and PGx, Grad.Sch.of Pharmceut.Sci., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 109-109, 2007.

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O3E2-1 BMP2 functions as a negative regulator in the differentiation of mouse tongue myoblasts

Akira Yamane1, Tadayoshi Fukui2, Takeo Suga3, Akiko Shinohara4
1Dept.Pharmacol., Tsurumi Univ.Sch.Dent.Med., 2Dept.Orthod., Tsurumi Univ.Sch.Dent.Med., 3Dept.Geriatr.Dent., Tsurumi Univ.Sch.Dent.Med., 4Grad.Sch.Human Sci., Waseda Univ
Journal of Pharmacological Sciences 103 (suppl.1) 109-109, 2007.

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O3E2-2 Visualization of Ca2+-induced Ca2+ release in smooth muscle cells using total internal reflection fluorescence microscope

Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept.Mol.＆ Cell.Pharmacol., Grad.Sch.Pharmaceut.Sci., Nagoya City Univ
Journal of Pharmacological Sciences 103 (suppl.1) 109-109, 2007.

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O3E2-3 Role of a cytoplasmic loop between M7b and M8 transmembrane helices of RyR1 in Ca2+ channel activity

Takashi Murayama1, Hideto Oyamada2, Toshiharu Oba3, Katsuji Oguchi2, Nagomi Kurebayashi1
1Dept.Pharmacol., Juntendo Univ.Sch.Med., 2Dept.Pharmacol.Showa Univ.Sch.Med., 3Nagoya City Univ Med.Sch
Journal of Pharmacological Sciences 103 (suppl.1) 110-110, 2007.

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O3E2-4 Activation of protein kinase B(Akt)and glucose uptake by passive stretch in mouse skeletal muscle.

Yoshihiko Ito, Kazuo Obara, Takaharu Fujii, Yusuke Wada, Koichi Nakayama, Tomohisa Ishikawa
Dept.Cell Mol.Pharmacol., Grad.Sch.Pharmaceut.Sci., Univ.Shizuoka
Journal of Pharmacological Sciences 103 (suppl.1) 110-110, 2007.

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O3E2-5 Alteration of male sexual function in alpha1A-, 1B- and 1D-adrenergic receptor triple knockout mouse

Atsushi Sanbe1, Yoshio Tanaka2, Youko Fujiwara1, Junji Yamauchi1, Katsuo Koike2, Gozoh Tsujimoto3, Akito Tanoue1
1Div.Exp.Pharmacol., Dept.Pharmacol., NRICHD, 2Dept.Chem.Pharmacol.Toho Univ.Sch of Pharmaceu.Sci., 3Dept.Genomic Drug Discovery Sci., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 110-110, 2007.

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O3F2-1 Molecular cloning and characterization of Monad binding protein 1 containing tetratricopeptide repeat domain

Yuki Itsuki1, 2, Makio Saeki1, Yasuyuki Irie3, Ko Okamura1, Hirohumi Yatani2, Yoshinori Kamisaki1
1Department of Pharmacology, Graduate School of Dentistry, Osaka University, 2Department of Fixed Prosthodontics, Graduate School of Dentistry, Osaka University, 3Department of Pharmacology, Osaka University Medical School
Journal of Pharmacological Sciences 103 (suppl.1) 110-110, 2007.

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O3F2-2 Knockdown of Monad expression by RNAi induces epithelial-mesenchymal transition

Miki Yoshida1, 2, Makio Saeki1, Hirokazu Nakahara3, Ko Okamura1, Yuudai Matsuoka4, Hitoshi Niwa2, Yoshinori Kamisaki1
1Dept.Pharmacol, Osaka Univ.Sch.Dent., 2Dept.Dental Anesthesiology.Osaka univ.Sch.Dent, 3Clinical Lab.Osaka univ.Dental hosp., 4Dept.Oral and Maxillofacial surg.1.Osaka univ.Sch.Dent
Journal of Pharmacological Sciences 103 (suppl.1) 111-111, 2007.

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O3F2-3 The inhibitory effect of connexin32 gene on metastasis in renal cell carcinoma

Hiromi Sato1, 2, Hironobu Senba1, Hiromi Hagiwara1, Etsuko Negishi2, Yoji Nagashima3, Tomohiro Yano1, Koichi Ueno2
1Nat.Inst.of Health and Nutrition, 2Faculty of Pharmaceutical Sciences, Chiba Univ., 3Dept.of Molecular Tumor Pathology, Yokohama City Univ.of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 111-111, 2007.

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O3G2-1 Depressive behavior induced by olfactory bulbectomy is improved by nefiracetam treatment in mice

Tetsuo Nakano1, Feng Han1, Shigeki Moriguchi1, Kohji Fukunaga1, 2
1Dept.Pharmacol., Tohoku Univ.Grad.Sch.Pharm.Sci., 2 21st Century COE Program CESCENDO
Journal of Pharmacological Sciences 103 (suppl.1) 111-111, 2007.

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O3G2-2 Intrathecal administration of interferon-γ activates spinal microglia and causes long-lasting tactile allodynia

Takahiro Masuda, Makoto Tsuda, Kazuhide Inoue
Dept.Mol.Syst.Pharmacol., Grad.Sch.Pharm.Sci., Kyushu Univ
Journal of Pharmacological Sciences 103 (suppl.1) 111-111, 2007.

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O3G2-3 Identification of an alternatively spliced soluble WSX-1 as a functional subunit of a heterotrimeric receptor for an anti-Alzheimer disease rescue factor Humanin

Yuichi Hashimoto1, 2, 3, Tmohiro Chiba1, Ikuo Nishimoto3, Sadakazu Aiso2, Masaaki Matsuoka1, 3
1Dept.Cell Biol.and Neurosci., KEIO Univ, Sch.Med., 2Dept.Anatomy, KEIO University School of Medicine, 3Dept.Pharmacology, KEIO University School of Medicine
Journal of Pharmacological Sciences 103 (suppl.1) 112-112, 2007.

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O3G2-4 Nasal Colivelin treatment ameliorates Alzheimer's cognitive deficits via the JAK2/STAT3 axis.

Marina Yamada1, Tomohiro Chiba1, 2, Jumpei Sasabe1, Maiko Sato1, Ikuo Nishimoto3, Sadakazu Aiso1, Masaaki Matsuoka3
1Dept.Anat., Keio Univ.Sch.Med., 2Dept.Cell.Biol.Neurosci., Keio Univ.Sch.Med., 3Dept.Pharmacol., Keio Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 112-112, 2007.

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O3I2-1 Pioglitazone shows beneficial effects against stroke events in Hypertensive Rats

Taishi Nakamura1, Eiichiro Yamamoto1, Takuro Yamashita1, Keiichiro Kataoka1, Hisao Ogawa2, Shokei Mitsuyama.Kim1
1Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 2Department of Cardiovascular medicine, Kumamoto University Graduate School of Medical Sciences
Journal of Pharmacological Sciences 103 (suppl.1) 112-112, 2007.

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O3I2-2 Electropharmacological effects of calcium channel blocker azelnidipine assessed in the halothane anesthetized canine model

Tomomichi Ishizaka1, Akira Takahara1, 2, Hiroshi Iwasaki1, Yuji Nakamura1, Atsushi Sugiyama1, 2
1Dept.Pharmacol., Univ of Yamanashi, 2Yamanashi Res.Center Clin.Pharmacol
Journal of Pharmacological Sciences 103 (suppl.1) 112-112, 2007.

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O3I2-3 Cardiotoxicity of clomipramine in chick embryos

Yuji Yoshiyama, Nami Kobayashi, Akie Nishihar, Ayano Shimizu, Kazumi Knai, Ayumi Sato, Motoko Kanke
Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
Journal of Pharmacological Sciences 103 (suppl.1) 113-113, 2007.

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O3I2-4 Prostaglandin E2 protects the heart from ischemia-reperfusion injury via its receptor subtype EP3

Koh-ichi Yuhki1, Chun Yang Xiao1, Akiyoshi Hara1, Jun-ichi Kawabe1, Shuh Narumiya2, Fumitaka Ushikubi1
1Dept.Pharmacol., Asahikawa Med.Coll., 2Dept.Pharmacol., Kyoto Univ., Fac.Med
Journal of Pharmacological Sciences 103 (suppl.1) 113-113, 2007.

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O3I2-5 Apoptosis Signal-Regulating Kinase 1(ASK1)plays a key role in vascular eNOS uncoupling in hypertension

Eiichiro Yamamoto, Yi.Fei Dong, Takuro Yamashita, Taishi Nakamura, Houichi Yorinaka, Keiichiro Kataoka, Yoshiko Tokutomi, Shokei Mitsuyama.Kim
Dept.Pharmacology and Molecular Therapeutics, Kumamoto Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 113-113, 2007.

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O3E3-1 Protease-activated receptor 4-mediated phenotypic changes in alveolar epithelial cells

Seijitsu Ando1, 2, Hitomi Otani1, Yasuhiro Yagi2, Kenzo Kawai3, Hiromasa Araki3, Chiyoko Inagaki1
1Dept.Pharmacol., Kansai Medical Univ., 21st Dept.of Internal.Med, Kansai Med Univ., 3Res.Dev.Center, Fuso Pharmaceu.Ind.Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 113-113, 2007.

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O3E3-2 Nitric oxide stimulates aquaporin-5 endocytosis through cGMP-independent pathway in lung epithelial cells

Megumi Watanabe1, Kazufumi Nagai1, Akari Arimatsu1, Akinori Hisatsune1, Takeshi Miyata1, 2, Yoichiro Isohama1
1Dept.Chemico-Pharmacol.Grad.Sch.Pharmac.Sci., 2Lab.Presymptomatic Med.Phram., Fac.Pharmac.Sci., Sojo Univ
Journal of Pharmacological Sciences 103 (suppl.1) 114-114, 2007.

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O3E3-3 Glycyrrhizin inhibits NF-KB-dependent gene transcription and lung inflammation not through glucocorticoid receptor

Hironori Takei1, Hiroki Nishimoto1, Akinori Hisatsune1, Takeshi Miyata1, 2, Yoichiro Isohama1
1Dept.Chemico-Pharmacol.Grad.Sch.Pharmac.Sci., 2Lab.Presymptomatic Med.Phram., Fac.Pharmac.Sci., Sojo Univ
Journal of Pharmacological Sciences 103 (suppl.1) 114-114, 2007.

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O3E3-4 Role of Th2 cytokines in the onset of asthmatic phenotypes induced by house dust mite in mice

Hiroyuki Tanaka1, Hiroyuki Tanaka1, Mikiko Hashimoto1, Kosuke Miyoshi1, Keiko Wakahara1, 2, Izumi Hirose1, 3, Naoki Inagaki1, Hiroichi Nagai4
1Dept.Pharmacol., Gifu Pharm.Univ., 2Dept.Respir.Med., Nagoya Univ.Graduate School Med, 3Dept.Pediatr., Nagoya Univ.Graduate School Med., 4Dept.Clin.Pharmacol., Gifu Pharm.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 114-114, 2007.

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O3F3-1 Effect of local application of PDGF on cell proliferation in healing periodontal ligament after tooth replantation

Koichiro Komatsu, Akemi Shimada, Tatsuya Shibata, Akira Nifuji
Dept.Pharmacol., Sch.Dent.Med., Tsurumi Univ
Journal of Pharmacological Sciences 103 (suppl.1) 114-114, 2007.

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O3F3-2 Calcium or magnesium dependent ATPase activity of a clonal osteoblastic cell

Makoto Obata1, Yoshiaki Deyama1, Waleed.R.El.Beialy1, Makoto Nishikata2, Yoshitaka Yoshimura1, Kazuaki Fukushima1, Kuniaki Suzuki1
1Dept.Oral Pathobiol.Sci., Grad.Sch.Dent.Med., Hokkaido Univ., 2Support Section Res.and Edu., Grad.Sch.Dent.Med, Hokkaido Univ
Journal of Pharmacological Sciences 103 (suppl.1) 115-115, 2007.

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O3F3-3 γ-glutamyltranspeptidase(GGT), a marker of inflammation, induces osteoclastogenesis by stimulating cytoskeletal rearrangement of preosteoclasts

Keiko Suzuki1, Sawako Moriwaki2, Shumpei Niida2, Shoji Yamada1
1Dept.Pharmacol., Sch.Dent., Showa Univ., 2Dept.Bone ＆ Joint Dis., Nail Center Geriatrics ＆ Gerontol
Journal of Pharmacological Sciences 103 (suppl.1) 115-115, 2007.

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O3F3-4 Osteoclast-inducing property alteration attributable to optical isomers of isoproterenol

Yukiko Fukawa1, Akiko Karakawa2, Masako Okazaki2, Matsuo Yamamoto1, Shoji Yamada2, Ken-ichi Miyamoto3, Hitoshi Amano2
1Dept.Periodontol.Showa Univ.Sch.Dent., 2Dept.Pharmacol.Showa Univ.Sch.Dent., 3Dept.Hospital Pharma.Kanazawa Univ.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 115-115, 2007.

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O3F3-5 Identification of genes regulated by Runx2/Cbfa1 in the ectopic bone formation in spinal ligament

Masaki Kishiya1, Ken-Ichi Furukawa1, Kouta Kanemaru1, Takuya Numasawa2, Toru Yokoyama2, Satoshi Toh2, Shigeru Motomura1
1Dept.of Pharmachology, School of Medicine, Hirosaki University, 2Dept.of Orthopaedic, School of Medicine, Hirosaki University
Journal of Pharmacological Sciences 103 (suppl.1) 115-115, 2007.

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O3G3-1 Ameliorating effects of an atypical antipsychotic, olanzapine, on AD/HD-like behavioral abnormalities in male juvenile SHRSP/Ezo

Taku Yamaguchi1, Hiroko Togashi1, 2, Machiko Mastumoto1, Takeshi Izumi1, Mitsuhiro Yoshioka1
1Dept.Neuropharmacol., Hokkaido Univ.Grad.Sch.Med., 2Dept.Pharmacol., Fac.Pharm.Sci., Hlth.Sci.Univ. Hokkaido
Journal of Pharmacological Sciences 103 (suppl.1) 116-116, 2007.

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O3G3-2 YM-244769, a novel NCX3-selective inhibitor, efficiently protects against neuronal hypoxia/reoxygenation injury

Satomi Kita, Takahiro Iwamoto
Dept.Pharmacol., Sch.Med., Fukuoka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 116-116, 2007.

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O3G3-3 Proteomic analysis in the prefrontal cortex of mice after repeated treatment of phencyclidine

Makiko Suzuki, Taku Nagai, Toshitaka Nabeshima
Dept.Neuropsychopharmacol.＆ Hosp.Pharm., Nagoya Univ., Grad.Sch.Med
Journal of Pharmacological Sciences 103 (suppl.1) 116-116, 2007.

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O3G3-4 The effect of oxycodone on bone cancer pain in FBC model

Kazuhisa Mihami1, Hisanori Ito1, Takako Tomii1, Mitsunobu Matsumoto2, Satoshi Orita2, Syuichi Matsushima3, Takako Miyoshi3, Mikinori Torii2, Katsumi Koike1, Shinji Shimada1, Toshiyuki Kanemasa1, Minoru Narita3, Tsutomu Suzuki3, Akira Kato1
1Discovery Research Laboratories, Shionogi ＆ CO., LTD., 2Development Research Laboratories, Shionogi ＆ CO., LTD, 3Dept.Toxicol., Hoshi Univ.Sch.Pharm.Pharmaceut.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 116-116, 2007.

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O3G3-5 Nicotine augments mRNA level of pituitary adenylate cyclase-activating polypeptide in PC12 cell

Aiko Tominaga1, Hideki Sugawara1, 2, Kazuhiko Inoue1, Shin-ichi Iwata1, Takao Shimizu1, Atsuro Miyata1
1Dept.Pharmacol., Grad.Sch.Med.Dent.Sci., Kagoshima Univ., 2Dept.Clinical Pharmacy and Pharmacology., Med.Dent.Hospital.Kagoshima Univ
Journal of Pharmacological Sciences 103 (suppl.1) 117-117, 2007.

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O3I3-1 Kinetic analysis of NO2- in vivo

Takaharu Ishibashi, Naoki Nishizawa, Ikumi Shinkawa, Junko Yoshida, Matomo Nishio
Dept.Pharmacol., Kanazawa Med.Univ
Journal of Pharmacological Sciences 103 (suppl.1) 117-117, 2007.

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O3I3-2 Redox-based S-nitrosylation of the slow delayed rectifier K+ channel, KCNQ1

Ken Asada, Junko Kurokawa, Tetsushi Furukawa
Depti.Bio-informational.Pharmacol., MRI, Tokyo Med＆Dent
Journal of Pharmacological Sciences 103 (suppl.1) 117-117, 2007.

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O3I3-3 Interleukin(IL)-11 prevents ischemia/reperfusion(I/R)injury in hearts as a novel cardioprotective cytokine.

Makiko Maeda1, Ryusuke Kimura3, Atsushi Arita1, Masanori Obana1, Yasuhiro Yamamoto1, Tomomi Mohri1, Tomohiko Iwakura1, Koichi Mastuda1, Takashi Ito1, Yasushi Kimura1, Yuichi Oshima1, 3, Yasushi Fujio1, Junichi Azuma1
1Dept.Clinical Evaluation of Medicines and Therapeutics, Osaka Univ.Sch.Pharm.Sci., 2The Japan Association for the Advancement of Medical Equipment, 3Dept.Molecular Med.Grad.Sch.Med.Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 117-117, 2007.

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O3I3-4 N-hexacosanol has therapeutic effects on diabetes-induced angiopathy in the rat aorta

Motoaki Saito1, Chiko Shinhori1, Emi Kazuyama1, Yoshie Hisadome1, Takuya Hanada1, Yukako Kinoshita1, Itaru Satoh1, Hiroto Suzuki2, Masashi Yamada2, Keisuke Satoh1
1Div.Mol.Pharmacol., Tottori Univ.Faculty Med., 2Meiji Dairies Corporation Pharmaceuticals Department
Journal of Pharmacological Sciences 103 (suppl.1) 118-118, 2007.

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O3I3-5 Slow voltage-dependent inactivation of the L-type Ca2+ channel Cav1.3.

Hiroko Izumi-Nakaseko, Hiromichi Tsuru, Satomi Adachi-Akahane
Dept.Pharmacol., Fac.Med., Toho Univ
Journal of Pharmacological Sciences 103 (suppl.1) 118-118, 2007.

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O3E4-1 Role of CpG methylation and Sp1 on cell type-specific expression of aquaporin-5 gene

Johji Nomura1, Akinori Hisatsune1, Takeshi Miyata1, 2, Yoichiro Isohama1
1Dept.Chemico-Pharmacol., Kumamoto Univ.Grad Sch.Pharmac.Sci., 2Lab.Presymptomatic Med.Pharm., Sojo Univ.Fac.Pharmac.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 118-118, 2007.

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O3E4-2 Role OF p38 α MITOGEN-ACTIVATED PROTEIN KINASE IN LUNG METASTASIS OF TUMOR CELLS

Yoshitoshi Kasuya1, Yuji Matsuo1, 2, Shinya Amano1, 2, Mitsuko Furuya3, Kana Namiki1, Kanako Sakurai1, Mariko Nishiyama1, Tatsuhiko Sudo4, Koichiro Tatsumi2, Takayuki Kuriyama2, Sadao Kimura1
1Dept.Biochem.Mol.Pharmacol., Grad.Sch.Med., Chiba Univ., 2Dept.Respirol, 3Mol.Pathol., 4Antibiotics Lab., RIKEN
Journal of Pharmacological Sciences 103 (suppl.1) 118-118, 2007.

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O3E4-3 Intranasal dosings of substance P(SP)and neurokinin A(NKA)induce nasal hyperresponsiveness(NHR)in a guinea pig model of allergic rhinitis

Yasuyoshi Otani1, Nobuaki Mizutani1, Masanori Fujii1, Takeshi Nabe1, Naoki Tsuzuike2, Shigekatsu Kohno1
1Department of Pharmacology, Kyoto Pharmaceutical University, 2ZERIA Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 103 (suppl.1) 119-119, 2007.

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O3E4-4 High-dose glucocorticoid treatment downregulates glucocorticoid receptor expression in septic guinea-pig lungs

Koki Kamiyama1, Naoyuki Matsuda1, Takuya Nagata2, Kazuhiro Tsukada2, Yuichi Hattori1
1Dpt.Mol.＆Med., Grad.Sch.Med.＆Pharm.Sci., Univ.of Toyama, 2Dpt.Surg, Grad.Sch.Med.＆Pharm.Sci., Univ.of Toyama
Journal of Pharmacological Sciences 103 (suppl.1) 119-119, 2007.

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O3F4-1 Roles of endogenous ADP in collagen-induced platelet aggregation-A study using bovine platelets with storage pool deficiency

Katsuyuki Ohnishi, Naofumi Honda, Masahiro Ikeda, Katsuaki Ito
Dept.Vet.Pharmacol., Fac.Agri., Univ.Miyazaki
Journal of Pharmacological Sciences 103 (suppl.1) 119-119, 2007.

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O3F4-2 Leukotriene B4 is involved in allergic ocular itch in mice

Tsugunobu Andoh1, Kazunari Sakai1, Masahisa Urashima1, Yasushi Kuraishi1, 2
1Dept Applied Pharmacol., Grad.School.Med.Pharm.Sci., Univ.Toyama, 2 21st Century COE Program
Journal of Pharmacological Sciences 103 (suppl.1) 119-119, 2007.

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O3F4-3 Cutaneous damage accelerates energy expenditure in NC/Nga mice with atopic-like dermatitis

Yusuke Honma, Iwao Arai, Nobuko Futaki, Yuki Hashimoto, Masanori Sugimoto, Shiro Nakaike
Medicinal Research laboratories, Taisho Pharmaceutical CO., LTD
Journal of Pharmacological Sciences 103 (suppl.1) 120-120, 2007.

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O3F4-4 Anti-inflammatory effect of ProstaglandinE2-EP3 signaling on mouse contact hypersensitivity model

Tetsuya Honda1, 2, Toshiyuki Matsuoka1, Yoshiki Miyachi2, Shuh Narumiya1
1Dept.Phamacol., Med., Kyoto Univ., 2Dept.of Med.Dermatol., Kyoto Univ
Journal of Pharmacological Sciences 103 (suppl.1) 120-120, 2007.

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O3G4-1 D1-like receptors selectively block P/Q-type calcium channels to inhibit glutamatergic transmission onto cholinergic neurons in the rat basal forebrain

Toshihiko Momiyama
Div.Cereb.Struc., Natl.Inst.Physiol.Sci
Journal of Pharmacological Sciences 103 (suppl.1) 120-120, 2007.

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O3G4-2 ADHD-like behaviors and hypoplasia of myelinated axons in Pl3 kinase knockout mice

Ruiko Nakanishi1, Chihiro Thoda1, Takako Yokozawa1, Takeshi Yamamoto2, Makoto Kadowaki2
1Div.of Biofunctional Evaluation, Res.Center for Ethnomed., Inst.of Natural Med., Univ.of Toyama, 2Div.of Gastrointestinal Pathophysiol., Inst.of Natural Med., Univ.of Toyama
Journal of Pharmacological Sciences 103 (suppl.1) 120-120, 2007.

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O3G4-3 Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain

Yutaka Koyama1, 2, 3, 4, Akemichi Baba2, Toshio Matsuda3, 4
1Lab.of Pharmacol., Faculty of Pharmacy, Osaka Ohtani Univ., 2Lab.of Mol.Neuropharmacol., Grad.Sch.of Pharmaceutical Sci., Osaka Univ., 3Lab.of Medicinal Pharmacol., Grad.Sch.of Pharmaceutical Sci., Osaka Univ., 4The Osaka-Hamamatsu Joint Research, Center for Mental Development, Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 121-121, 2007.

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O3G4-4 Effect of edaravone on MPTP-induced neurotoxicity and behavioral impairment in mice.

Toshiyuki Kawasaki1, Kotarou Ishihara1, Tetsuaki Nashida1, Yukio Ago1, Akemichi Baba2, Toshio Matsuda1, 3
1Lab.Medicinal Pharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 2Lab.Mol.Neuropharmacol., Grad.Sch.Pharmaceut.Sci., Osaka Univ., 3Center for Child Mental Dev., Grad.Sch.Med., Osaka Univ
Journal of Pharmacological Sciences 103 (suppl.1) 121-121, 2007.

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