Journal of Pharmacological Sciences 118巻 suppl号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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SL1 Pancreatic β-cell signaling and anti-diabetic drugs

Susumu Seino
Division of Diabetes and Endocrinology /Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine
Journal of Pharmacological Sciences 118 (suppl) 2-2, 2012.

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SL2 Phenotype pharmacology as a new dimension of receptor pharmacology

Ikunobu Muramatsu
Department of Biochemistry and Bioinformative Sciences, School of Medicine, University of Fukui Eiheiji
Journal of Pharmacological Sciences 118 (suppl) 2-2, 2012.

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SL3 Pain relief by opioid analgesics without psychological dependence

Tsutomu Suzuki
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences
Journal of Pharmacological Sciences 118 (suppl) 2-2, 2012.

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SL4 Nitric oxide： the whispering transmitter

John Garthwaite
University College London
Journal of Pharmacological Sciences 118 (suppl) 2-2, 2012.

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SL5 Regnase-1/Zc3h12a, an endoribonuclease essential for regulation of the immune response

Shizuo Akira
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 2Fl. IFReC Building, Osaka University
Journal of Pharmacological Sciences 118 (suppl) 3-3, 2012.

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SL6 Glutamate Receptors to Brain Development and Function

Masayoshi Mishina
Department of Molecular Neurobiology and Pharmacology, Graduate School, of Medicine, The University of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 3-3, 2012.

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SL7 Function and Regulation of Adult Neurogenesis

Fred H. Gage
The Salk Institute for Biological Studies
Journal of Pharmacological Sciences 118 (suppl) 3-3, 2012.

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SL8 The gene as a drug： exploring the possibilities with salivary glands

Bruce J. Baum
Hebrew University, Jerusalem, Israel and Former Chief, Gene Transfer Section, NIDCR, NIH
Journal of Pharmacological Sciences 118 (suppl) 3-3, 2012.

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SL9 Presenilin Function in Health and Disease

Sangram S. Sisodia
Center for Molecular Neurobiology, Department of Neurobiology, The University of Chicago
Journal of Pharmacological Sciences 118 (suppl) 4-4, 2012.

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EAL Pharmacological adventures in prostanoid receptors and the small GTPase Rho

Shuh Narumiya
Department of Pharmacology, Kyoto University Faculty of Medicine
Journal of Pharmacological Sciences 118 (suppl) 6-6, 2012.

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AL1 The mechanism of calcitonin gene-related peptide containing nerve innervation

Narumi Hashikawa-Hobara
Dept. of Life Sci., Okayama Univ. of Sci.
Journal of Pharmacological Sciences 118 (suppl) 8-8, 2012.

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AL2 Elucidation of signal response mechanisms in bone-related cell lineages

Eiichi Hinoi
Laboratory of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
Journal of Pharmacological Sciences 118 (suppl) 8-8, 2012.

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AL3 Roles of prostaglandin E2-mediated dopaminergic regulation for emotional behavior under stress

Tomoyuki Furuyashiki
Department of Pharmacology, Kyoto University Graduate School of Medicine
Journal of Pharmacological Sciences 118 (suppl) 8-8, 2012.

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S1M-1-1 Roles of TRPM2 in the inflammatory and neuropathic pain

Shuji Kaneko, Kayo Haraguchi, Hisashi Shirakawa, Takayuki Nakagawa
Dept. Mol. Pharmacol., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 10-10, 2012.

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S1M-1-2 TRPV3 and TRPV4 channels as targets for skin treatments

Makoto Tominaga1, 2
1Div. Cell Signaling, Okazaki Inst. Integrative Biosci., 2Dept. Physiol. Sci., SOKENDAI
Journal of Pharmacological Sciences 118 (suppl) 10-10, 2012.

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S1M-1-3 TRPA1 senses oxygen availability.

Nobuaki Takahashi1, 3, Shigeki Kiyonaka2, 3, Tomohiro Numata2, 3, Daisuke Kozai3, Yasuo Mori2, 3
1Adv. Biomed. Engn. Res. Unit, Kyoto Univ., Kyoto University Katsura Campus A4-219, 2Dept. Technol. & Ecol., Kyoto Univ., Kyoto University Katsura Campus A4-219, 3Dept. Synthet. Chem. & Biol. Chem., Kyoto Univ., Grad. Sch. Engn., Kyoto University Katsura Campus A4-219
Journal of Pharmacological Sciences 118 (suppl) 10-10, 2012.

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S1M-1-4 Role of diacylglycerol-activated TRPC channels in cardiac fibrosis

Motohiro Nishida, Naoyuki Kitajima, Michio Nakaya, Hitoshi Kurose
Dept. of Pharmacol. & Toxicol., Grad. Sch. of Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 10-10, 2012.

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S1A-2-1 In vitro and in vivo pharmacological profiles of a novel angiotensin type 1 receptor blocker, azilsartan

Keiji Kusumoto
Metabolic Disease Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd.
Journal of Pharmacological Sciences 118 (suppl) 11-11, 2012.

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S1A-2-2 Usefulness of mineralocorticoid receptor antagonist for the treatment of resistant hypertension

Kohei Kikkawa
Pharmacol. Res. Lab. II, Mitsubishi Tanabe Pharma Corp.
Journal of Pharmacological Sciences 118 (suppl) 11-11, 2012.

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S1A-2-3 Combination therapy for antihypertensive patients： End-organ protective effect of combination with ARB and CCB

Makoto Mizuno
Biological Research Laboratories, Daiichi Sankyo Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 11-11, 2012.

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S1A-2-4 Possibility of development of Rho kinase inhibitors for cardiovascular diseases

Minoru Seto
Lab. Pharmacol., Asahi KASEI Pharma
Journal of Pharmacological Sciences 118 (suppl) 11-11, 2012.

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S1D-3-1 ATP hydrolysis-driven gating of an ABC transporter CFTR channel： From stills to movies.

Yoshiro Sohma
Dept. Pharmacol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 12-12, 2012.

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S1D-3-2 Structure basis of a regulatory module of TRP channel homolog

Atsuko Yamashita, Makoto Ihara
RIKEN SPring-8 Center
Journal of Pharmacological Sciences 118 (suppl) 12-12, 2012.

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S1D-3-3 Single-molecule analyses of the reactions and movements of ErbB receptors

Yasushi Sako
Cellular Informatics Lab., RIKEN ASI
Journal of Pharmacological Sciences 118 (suppl) 12-12, 2012.

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S1D-3-4 Immuno-EM of cells in solution using the Atmospheric Scanning Electron Microscope (ASEM)

Chikara Sato1, Tatsuhiko Ebihara1, Hidetoshi Nishiyama2, Mitsuo Suga2, Yuusuke Maruyama1
1Biomed-ri, AIST, AIST Tsukuba Central6, 2JEOL
Journal of Pharmacological Sciences 118 (suppl) 12-12, 2012.

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S1E-4-1 LYMPHANGIOGENESIS： THE PLASTICITY OF LYMPHATICS IN DISEASE

Donald M. McDonald
Comprehensive Cancer Center, Cardiovascular Research Institute, and Department of Anatomy, University of California-San Francisco
Journal of Pharmacological Sciences 118 (suppl) 13-13, 2012.

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S1E-4-2 Roles of Prostaglandins in enhancement of lymphangiogenesis in pathological states

Masataka Majima, Kanako Hosono, Tatsunori Suzuki, Shinya Kashiwagi
Dept. Pharmacol., Kitasato Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 13-13, 2012.

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S1E-4-3 Roles of BMP-9 signals in the formation of blood and lymphatic vessels

Tetsuro Watabe
Dept. Mol. Pathol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 13-13, 2012.

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S1E-4-4 VEGF-C and VEGF R3 contribute to reconnection of collecting lymph vessels.

Yoshiko Kawai, Toshio Ohhashi
Dept. Phsyiol., Shinshu Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 13-13, 2012.

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S1A-5-1 Ryanodine receptor abnormality as a cause of heart failure and lethal arrhythmia

Masafumi Yano
Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
Journal of Pharmacological Sciences 118 (suppl) 14-14, 2012.

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S1A-5-2 SERCA2 as a cause and therapeutic target of heart failure

Masashi Arai
Dept. Med & Biol Sci. Gunma Univ. Grad Sch Med
Journal of Pharmacological Sciences 118 (suppl) 14-14, 2012.

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S1A-5-3 Calcium channels as novel therapeutic targets in heart failure

Koichiro Kuwahara, Hideyuki Kinoshita, Kazuwa Nakao
Dept. Medicine and Clinical Science, Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 14-14, 2012.

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S1A-5-4 Oxidative stress and calcium overload in heart failure

Kazufumi Nakamura, Daiji Miura, Hiroshi Ito
Department of Cardiovascular Medicine, Okayama University Hospital
Journal of Pharmacological Sciences 118 (suppl) 14-14, 2012.

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S1A-5-5 Calcium-mediated pathogenesis in heart

Hiroyuki Nakayama, Yasushi Fujio
Dep. Pharmaceutical Sci., Osaka Univ
Journal of Pharmacological Sciences 118 (suppl) 15-15, 2012.

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S1D-6-1 Fast three-dimensional EPR imaging of in vivo redox mapping

Hiroshi Hirata
Grad. School of Info. Sci. & Tech., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 16-16, 2012.

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S1D-6-2 Spatial-temporal Assessment of Blood-Brain Barrier Dysfunction using Gadolinium enhanced-Magnetic Resonance Imaging

Kouichi Itoh
Lab. Brain Sci., Tokushima Bunri Univ. Kagawa Sch. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 16-16, 2012.

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S1D-6-3 Magnetic Resonance-Based Molecular Imaging Studies of Mice by Using Paramagnetic Contrast Probes

Hirotada Fujii, Miho Emoto
Center for Medical Education, Sapporo Medical University
Journal of Pharmacological Sciences 118 (suppl) 16-16, 2012.

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S1D-6-4 Applications of Magnetic Resonance Imaging in Drug Discovery and Development

Makoto Ishikawa
Otsuka Pharma. Tokushima Res. Inst.
Journal of Pharmacological Sciences 118 (suppl) 16-16, 2012.

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S1E-7-1 The utility of Microminipigs for pharmacokinetic studies in vitro and in vivo

Hiroshi Yamazaki
Showa Pharma Univ
Journal of Pharmacological Sciences 118 (suppl) 17-17, 2012.

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S1E-7-2 Potential utility of Microminipigs as a tool of cardiovascular safety pharmacology

Yasuki Akie1, 2, Hiroyuki Saito1, 2, Yukitoshi Nagayama1, Kiyotaka Hoshiai1, Yuji Nakamura2, Atsushi Sugiyama2
1CMIC BIORESEARCH CENTER, 2Department of Pharmacology, Faculty of Medicine, Toho University
Journal of Pharmacological Sciences 118 (suppl) 17-17, 2012.

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S1E-7-3 Total assessment of drug-induced ECG changes by Microminipigs

Atsushi Sugiyama, Yuji Nakamura, Ken Kitahara, Hiroyuki Saito, Yasuki Akie
Department of Pharmacology, Faculty of Medicine, Toho University
Journal of Pharmacological Sciences 118 (suppl) 17-17, 2012.

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S1E-7-4 Atherosclerosis and cholesterol metabolism in Microminipig

Akihide Tanimito1, Hiroaki Kawaguchi2, Noriaki Miyoshi2
1Dept. Mol. and Cell. Pathol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 2Dept. Vet. Pathol., Agri., Kagoshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 17-17, 2012.

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S1A-8-1 Role of MicroRNA-210 and Potential Drug Target in Esophageal Squamous Cell Carcinoma

Soken Tsuchiya
Dep. Nanobio Drug Discovery, Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 18-18, 2012.

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S1A-8-2 Omics-based Drug Discovery against Tumor Angiogenesis

Yasuhito Shimada1, 2, 3, 4, Junya Kuroyanagi1, Yuhei Nishimura1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Pharmacogenom., Mie Univ. Sch. Med., 2Mie Univ. Med. Zebrafish Res. Cent., 3Dept. Bioinfo. Mie Univ. Life Sci. Res. Cent., 4Depart. Omics Med. Mie Univ. Indust. Tech. Innov. Inst.
Journal of Pharmacological Sciences 118 (suppl) 18-18, 2012.

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S1A-8-3 Hsp70 interactomics in cancer science

Masayuki Shiota, Masako Tanaka, Hiroshi Iwao
Dept. Pharmacol., Osaka City Univ., Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 18-18, 2012.

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S1A-8-4 Discovery research of a new selective ALK inhibitor

Hiroshi Sakamoto
Kamakura Research Laboratories, Chugai Pharmaceutical Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 18-18, 2012.

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S1D-9-1 Application of novel in vivo imaging and omics technology in drug discovery

Yuhei Nishimura1, 2, 3, 4, Yasuhito Shimada1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Mol. and Cell. Pharmacol., Pharmacogeno. and Pharmacoinfor., Mie Univ. Grad. Sch. Med, 2Mie Univ. Med. Zebra. Res. Cent., 3Dept. Bioinfo. Mie Univ. Life Sci. Res. Cent., 4Dept. Omics Med., Mie Univ. Indu. Tech. Innov. Inst.
Journal of Pharmacological Sciences 118 (suppl) 19-19, 2012.

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S1D-9-2 Drug Discovery and Development using Omics and Molecular Imaging Technologies

Ryuji Hiramatsu
Genomic Science Lab., Dainippon Sumitomo Pharma. Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 19-19, 2012.

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S1D-9-3 Innovative Drug Development by Efficient and Multi-phase Application of Molecular Imaging

Yasuyoshi Watanabe1, 2
1RIKEN Center for Mol. Imag. Sci., 2Osaka City Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 19-19, 2012.

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S1D-9-4 Splicing imaging and its application for the development of clinical drugs of RNA diseases

Masatoshi Hagiwara
Dept. of Anat. & Dev. Biol., Grad. Sch. of Med. Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 19-19, 2012.

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S1E-10-1 Basics and practice of alternatives to animal experiments

Yuji Yoshiyama
Div. Community Pharm., Kitasato Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 20-20, 2012.

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S1E-10-2 Situation at the Ministry of the Environment for the Amendment of the Animal Protection Law

Yoshihiro Hayashi
Faculty of Agriculture, Tokyo University of Agriculture
Journal of Pharmacological Sciences 118 (suppl) 20-20, 2012.

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S1E-10-3 International situation of alternative to animal testing

Hajime Kojima
Japanese Center for the Validation of Alternative Methods, National Institute of Health Sciences
Journal of Pharmacological Sciences 118 (suppl) 20-20, 2012.

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S1E-10-4 Role of statisticians in data management, study design, and data analysis in validation studies for alternatives to animal testing

Takashi Omori
Facult. Culture and Information Sci., Doshisha Univ.
Journal of Pharmacological Sciences 118 (suppl) 20-20, 2012.

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S1E-10-5 Response to revised Act on Welfare and Management of Animals

Takuya Ikeda
Charles River Laboratories Japan
Journal of Pharmacological Sciences 118 (suppl) 21-21, 2012.

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S1A-11-1 Approach for identifying novel drug targets of schizophrenia

Takahiko Yano
CNS DDU, pharmaceutical research division, Takeda Pharmaceutical Company
Journal of Pharmacological Sciences 118 (suppl) 22-22, 2012.

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S1A-11-2 Discovery of novel antipsychotics targeting group II metabotropic glutamate receptor

Tetsuaki Hiyoshi1, Shigeyuki Chaki1, Shigeru Okuyama2
1Mol. Func. Pharmacol. Labs., Taisho Pharmaceutical Co.,Ltd., 2Research Headquarters of Pharmaceutical Operation, Taisho Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 22-22, 2012.

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S1A-11-3 Innovation of animal models for cognitive impairment in schizophrenia (CIS)

Kazuhito Ikeda
Pharmacol. Research Lab., Dainippon Sumitomo Parma Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 22-22, 2012.

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S1A-11-4 The role of neuroimaging biomarker in drug discovery for schizophrenia

Satoshi Ozaki
Bioimaging Research Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 118 (suppl) 22-22, 2012.

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S1D-12-1 Migratory control of bone-resorbing osteoclasts visualized by intravital multiphoton microcopy

Masaru Ishii1, 2, Junichi Kikuta1, 2
1Lab. Cellular Dynamics, IFReC, Osaka Univ., 2JST, CREST
Journal of Pharmacological Sciences 118 (suppl) 23-23, 2012.

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S1D-12-2 In vivo optical bioimaging of hypoxia inducible factor activity

Shinae Kondoh, Takahiro Kuchimaru, Tetsuya Kadonosono
Dept. Biomolecular Engineering, TIT, Sch. Biosci. Biotech.
Journal of Pharmacological Sciences 118 (suppl) 23-23, 2012.

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S1D-12-3 In vivo molecular imaging reveals parenchymal and interstitial cell cross-talks in chronic inflammatory diseases

Satoshi Nishimura1, 2, Mika Nagasaki1, 2, 3, Ichiro Manabe1, 2, Koji Eto4, Ryozo Nagai1, 2
1Dept. of Cardiovasc. Med., The Univ. of Tokyo, 2TSBMI, The Univ. of Tokyo, 3Comp. Diag Radio and Prev Med, The Univ. of Tokyo, 4Kyoto Univ. Clinical Application Section, Center for iPS Cell Research and Application
Journal of Pharmacological Sciences 118 (suppl) 23-23, 2012.

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S1E-13-1 Kampo medicines as a complementary and alternative medicine (CAM)

Hiroyasu Satoh
Dept. Pharmacol. Nara Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 24-24, 2012.

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S1E-13-2 Vascular pharmacology of Kampo medicines for Mibyo

Seiichiro Nishida1, 2, Hiroyasu Satoh2
1Dongo Hospital, 2Dept. Pharmacol., Nara Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 24-24, 2012.

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S1E-13-3 Pathogenesis of influenza and preventive effects of herbal medicines, glucan and lactic acid bacteria

Tadaaki Miyazaki
Probio., Inst. Genet. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 24-24, 2012.

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S1E-13-4 Pharmacological studies of Yokukansan on the ameliorative effects on memory deficits and abnormal behavior in animal model of dementia

Katsunori Iwasaki1, 2, Kotaro Takasaki1, Ai Nogami1, 2, Shutaro Katsurabayashi1, Kaori Kubota1, Kenichi Mishima1, 2, Michihiro Fujiwara1
1Dept. Neuropharmacol., Fac. Pharmac. Sci., Fukuoka Univ., 2A.I.G. Institute for Aging and Brain Sciences
Journal of Pharmacological Sciences 118 (suppl) 24-24, 2012.

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S1E-13-5 Approach to evidence-based aromatherapy： Pharmacological effects of inhaled aromatic natural medicines

Ken Ito1, Michiho Ito2, Kyoko Takahashi3
1Museum of Osaka Univ., 2Grad. Sch. Pharmaceut. Sci., Kyoto Univ., 3Grad. Sch. Pharmaceut. Sci., Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 25-25, 2012.

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S2M-14-1 Regulation of adrenal aldosterone biosynthesis in salt-sensitive rats on a high-salt intake

Motoaki Sano1, Shintaro Morizane1, 2, Kae Ozawa1, 2, Takeshi Suzuki2, Keiichi Fukuda1
1Department of Cardiology, Keio University School of Medicine, 2Division of Basic Biological Sciences Faculty of Parmacy Keio University
Journal of Pharmacological Sciences 118 (suppl) 26-26, 2012.

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S2M-14-2 Cell communication in development of cardiorenal metabolic syndrome

Ichiro Manabe
Dept. Cardiovasc. med, Univ. Tokyo. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 26-26, 2012.

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S2M-14-3 Development of novel therapeutic agents for the treatment of renal cardiovascular diseases： Inhibitors of Plasminogen Inhibitor 1 and Oxygen sensor prolylhydroxylase

Toshio Miyata
Tohoku Univ. Graduate Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 26-26, 2012.

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S2A-15-1 Translational Research-Towards Personalized Medicine

Taro Tokui
Daiichi Sankyo Co.,Ltd., Translational Medicine and Clinical Pharmacology Dept., Research Group 2
Journal of Pharmacological Sciences 118 (suppl) 27-27, 2012.

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S2A-15-2 Utility of microdose study for drug discovery and development

Yoshiyuki Yamaura
DMPK research group, Discovery Technology Lab., ONO Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 27-27, 2012.

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S2A-15-3 The role of Pharmacogenomics in Translation Research

Shyh-Yuh Liou
Clinical Data Science Dept, Japan Develop. Center, Pharm. Develop. Div. Takeda Pharm. Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 27-27, 2012.

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S2A-15-4 Positron Emission Tomography as a Research Tool for Translational Science

Shintaro Nishimura
Bioimaging Res. Labs., Astellas Pharma Inc.
Journal of Pharmacological Sciences 118 (suppl) 27-27, 2012.

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S2D-16-1 Regulation of dopamine D2 receptor function through fatty acid-binding protein

Kohji Fukunaga, Norifumi Shioda
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Scis
Journal of Pharmacological Sciences 118 (suppl) 28-28, 2012.

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S2D-16-2 Effect of caveolin-1 on EGFR transactivation by angiotensinII in vascular smooth muscle cells.

Akira Takaguri
Dept. Pharmacol., Hokkaido Pharmaceu Uni
Journal of Pharmacological Sciences 118 (suppl) 28-28, 2012.

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S2D-16-3 Identification and functions of α1-adrenoceptor-interacting proteins

Ikunobu Muramatsu, Hatsumi Yoshiki, Abu Syed MD Anisuzzaman, Junsuke Uwada, Atsushi Nishimune
Dept. Pharmacol., Fukui Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 28-28, 2012.

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S2D-16-4 New functions of G protein-coupled receptor kinase and β-arrestin

Michio Nakaya, Satsuki Chikura, Kenji Watari, Motohiro Nishida, Hitoshi Kurose
Dept. Pharmacol. Toxicol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 28-28, 2012.

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S2E-17-1 Attenuation of the mesocortical dopaminergic pathway and concomitant microglial activation in repeated social defeat stress in mice：Possible link via prostaglandin signaling

Tomoyuki Furuyashiki1, Kohei Tanaka1, Shiho Kitaoka1, Yuki Imoto2, Eri Segi-Nishida2, Yuta Senzai1, Yuichi Deguchi1, Shuh Narumiya1
1Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med., 2Dept. Systems Bioscience for Drug Discovery, Kyoto Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 29-29, 2012.

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S2E-17-2 Oligodendrocyte dysfuction hypothesis in schizophrenia and beyond.

Kenji Tanaka1, Yoshihiko Yamazaki2, Kazuhiro Ikenaka1
1Div. Neurobiol and Bioinfo, NIPS, 2Dept Physiol., Yamagata Univ., Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 29-29, 2012.

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S2E-17-3 Impairment of neuropsychological development and its mechanism induced by perinatal immune activation

Taku Nagai, Daisuke Ibi, Shinnosuke Yamada, Kiyofumi Yamada
Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 29-29, 2012.

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S2A-18-1 Potentiality of generating gametes from pluripotent stem cells in culture.

Toshiaki Noce
Advanced Research Center, Keio Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 30-30, 2012.

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S2A-18-2 Chemical biology for cardiovascular cell differentiation and regeneration with ES & iPS cells

Jun Yamashita
Lab. of Stem Cell Differentiation, Inst. for Frotier Med. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 30-30, 2012.

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S2A-18-3 Liver stem/progenitor cells in development and regeneration

Atsushi Miyajima
Inst. Mol. Cell. Bio. Univ, Tokyo
Journal of Pharmacological Sciences 118 (suppl) 30-30, 2012.

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S2A-18-4 Activity of fat cell differentiation in diabetic conditions

Takeshi Imamura1, Masashi Tawa1, Ayman Geddawy1, Takashi Shimosato1, Akihiko Kusanagi2, Toshiaki Nose3, Ryuzou Torii2, Tomio Okamura1
1Dept. Med., Shiga Univ. Med. Sci., 2RCALS., Shiga Univ. Med. Sci., 3Dept. Physiol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 30-30, 2012.

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S2D-19-1 Diacylglycerol kinase as a possible drug target

Yasuhito Shirai1, Naoaki Saito2
1Agrobioscience, Grad. Sch. Agricul. Sci., Kobe Univ., 2Mol. Pharm., Biosignal Res. Ctr., Kobe Univ.
Journal of Pharmacological Sciences 118 (suppl) 31-31, 2012.

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S2D-19-2 Poly (ADP-ribose) polymerase-1 as a target for drug development

Mitsuko Masutani
Div. of Genome Stability Res., Natl. Cancer Ctr. Res. Inst.
Journal of Pharmacological Sciences 118 (suppl) 31-31, 2012.

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S2D-19-3 CNS injury and Rho family GTPases

Takehiko Ueyama, Naoaki Saito
Lab. Molec. Pharmacol., Biosignal Res. Ctr., Kobe Uni.
Journal of Pharmacological Sciences 118 (suppl) 31-31, 2012.

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S2D-19-4 Exploring the drug targets using natural resources-derived anti-allergic compounds that suppress up-regulation of allergic diseases sensitive gene expression.

Hiroyuki Mizuguchi, Hiroyuki Fukui
Dep. of Mol. Pharmacol., Inst. of Health Biosciences, The Univ. of Tokushima Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 31-31, 2012.

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S2E-20-1 The roles of glial cells in non-cell autonomous neurodegeneration in ALS

Koji Yamanaka
RIKEN BSI
Journal of Pharmacological Sciences 118 (suppl) 32-32, 2012.

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S2E-20-2 Glial TRP channels as therpeutic targets for stroke

Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 32-32, 2012.

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S2E-20-3 Understanding of the mechanism underlying neuropathic pain by glial cells

Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 32-32, 2012.

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S2E-20-4 Astrocyte as a target for anti-depressants

Schuichi Koizumi
Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi
Journal of Pharmacological Sciences 118 (suppl) 32-32, 2012.

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S2A-21-1 Alleviation of adverse drug reactions by EcoPharma

Ryozo Oishi
Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 118 (suppl) 33-33, 2012.

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S2A-21-2 Pharmacogenomic approaches for anticipating and avoiding adverse drug reactions

Hirotoshi Echizen
Dept Pharmacotherapy, Meiji Pharm Univ
Journal of Pharmacological Sciences 118 (suppl) 33-33, 2012.

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S2A-21-3 Circadian clock-regulareted drug disposition and alleviation of adverse drug reactions

Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo
Dept. Pharmaceuti., Grad. Sch., Kyshu Univ.
Journal of Pharmacological Sciences 118 (suppl) 33-33, 2012.

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S2A-21-4 Application of chronotherapy to decrease side effects

Hideto To
Dept. Medical Pharmaceutics, Toyama Univ.
Journal of Pharmacological Sciences 118 (suppl) 33-33, 2012.

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S2D-22-1 Impaired insulin signaling in the endothelial cells reduces insulin-induced glucose uptake by the skeletal muscle

Naoto Kubota, Tetsuya Kubota, Takashi Kadowaki
Dept. Diabetes and Metabolic Diseases, Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 34-34, 2012.

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S2D-22-2 Particulates control immune responses via signaling by lipid mediator.

Etsushi Kuroda
Dept. Immunol. and Parasitol., Univ. Occup. Envuron. Health, Japan., Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 34-34, 2012.

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S2D-22-3 POST-TRANSCRIPTIONAL SIGNALING MECHANISMS CONTROLLING TYROSINE HYDROXYLASE mRNA AND THEIR RELATIONSHIP TO STRESS AND PARKINSON'S DISEASE

A. William Tank, Nicole Boschi, Carol R. Sterling
Department of Pharmacology & Physiology, University of Rochester Medical Center
Journal of Pharmacological Sciences 118 (suppl) 34-34, 2012.

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S2D-22-4 Pharmacological effects of flavonoids derived from plants on catecholamine signaling and its drug developments

Nobuyuki Yanagihara1, Yumiko Toyohira1, Susumu Ueno2, Masato Tsutsui3, Han Zhang4
1Dept. Pharmacol., Univ. Occup. & Env. Health, Sch. Med., 2Dept. of Occup. Toxicol., Instit. Industr. Ecolog. Sci., Univ. Occup. & Envir. Health., 3Dept. Pharmacol., Grad. Sch. Med., Univ. The Ryukyus, 4Inst. Tradit. Chinese Med. Res., Tianjin Univ. Tradit. Chinese Med.
Journal of Pharmacological Sciences 118 (suppl) 34-34, 2012.

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S2E-23-1 The establishment of analysis methods for cardiovascular genetic diseases using human iPS cells

Shinsuke Yuasa1, 2
1Department of Cardiology, Keio University School of Medicine, 2Center for Integrated Medical Research, Keio University School of Medicine
Journal of Pharmacological Sciences 118 (suppl) 35-35, 2012.

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S2E-23-2 Quasi-in vivo assay： Functional reconstruction of cardiomyocyte network for cardiovascular toxicity predictive screening

Fumimasa Nomura, Tomoyuki Kaneko, Kenji Yasuda
Inst. of Biomaterials & Bioengineering, Tokyo Medical & Dental Univ.
Journal of Pharmacological Sciences 118 (suppl) 35-35, 2012.

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S2E-23-3 In vivo functional analysis of cardiovascular system using zebrafish

Seiji Takashima
Dept. Mol. Cardiology. Osaka Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 35-35, 2012.

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S2E-23-4 In silico arrhythmology： Significance of computer simulation to the drug-induced arrhythmogenicity.

Takashi Ashihara
Dept. Cardiovasc. Med., Shiga Univ. Med. Sci.
Journal of Pharmacological Sciences 118 (suppl) 35-35, 2012.

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S2A-24-1 Biomarker research of a novel angiogenesis inhibitor E7820 regulating integrin α2 expression

Taro Semba1, Yasuhiro Funahashi2
1Oncology PCU, Eisai, 2Biomarkers & Personalized Medicine, Eisai
Journal of Pharmacological Sciences 118 (suppl) 36-36, 2012.

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S2A-24-2 Drug discovery and research of Hsp90 inhibitor

Shiro Soga1, Takayuki Nakashima1, Toshihiro Seike1, Toshihiko Ishii2, Yukimasa Shiotsu3, Shiro Akinaga4
1Drug Discovery Research Lab, Kyowa Hakko Kirin Co.,Ltd., 2Pharmacological Research Lab, Kyowa Hakko Kirin Co.,Ltd., 3Biologics Research Lab, Kyowa Hakko Kirin Co.,Ltd., 4Development Division, Kyowa Hakko Kirin Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 36-36, 2012.

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S2A-24-3 Progress of research and development of MAPK pathway inhibitors

Nobuya Ishii, Yasushi Yoshimura, Naoki Harada, Yasushi Tomii, Yuko Aoki, Yuji Ishikawa
CHUGAI PHARMACEUTICAL CO.,LTD
Journal of Pharmacological Sciences 118 (suppl) 36-36, 2012.

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S2A-24-4 RANKL inhibition in bone metastases

Teiji Wada
Oncology Res. Lab., Daiichi Sankyo Co.,LTD.
Journal of Pharmacological Sciences 118 (suppl) 36-36, 2012.

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S2E-25-1 Strategy for the structure determination of G protein-coupled receptor

Takuya Kobayashi1, 2, 3, Mitsunori Shiroishi3, 4, Hidetsugu Asada1, 3, Takami Yurugi1, 3, Tatsuro Shimamura1, 3, So Iwata1, 3
1Dept. of Med. Chem. and Cell Biol., Kyoto Univ., 2JST CREST, 3JST ERATO, 4Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 37-37, 2012.

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S2E-25-2 Structure of the muscarinic acetylcholine receptor M2 subtype bound with an antagonist QNB (3-quinuclidinyl benzilate)

Tatsuya Haga1, Kazuko Haga1, Andrew C. Kruse2, Brian K. Kobilka2, Hidetsugu Asada3, Takuya Kobayashi3
1Dept. Life Sci., Fac. Sci., Gakushuin Univ., 2Dept. Mol. Cell. Physiol., Stanford Univ. School. Med., 3Dept. Med. Chem., Fac. Med., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 37-37, 2012.

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S2E-25-3 In silico structure-based drug design for GPCRs

Takatsugu Hirokawa
Comp. Biol. Res. Ctr., Natl. Inst. Adv. Indust. Sci. & Tech.
Journal of Pharmacological Sciences 118 (suppl) 37-37, 2012.

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S2E-25-4 In silico drug discovery using multiple compound-protein interactions

Yasushi Okuno
Grad. Sch. of Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 37-37, 2012.

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S3M-26-1 Cathepsin E-induced growth arrest and apoptosis of cancer cells and the related signaling

Kenji Yamamoto1, Tomoyo Kawakubo1, Atsushi Yasukochi1, Takayuki Tsukuba2
1Proteolysis Res Lab, Gad Sch Pharmaceu Sci, Kyushu Univ, 2Dept Dent Pharmacol, Grad Sch Biomed Sci, Nagasaki Univ
Journal of Pharmacological Sciences 118 (suppl) 38-38, 2012.

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S3M-26-2 The involvement of matrix metalloproteinase and its target molecule, neural cell adhesion molecules, in the development of brain infarction

Wakako Fujita-Hamabe1, Shinichi Harada1, Hiroyuki Mizoguchi2, Kiyofumi Yamada3, Toshitaka Nabeshima4, Shogo Tokuyama1
1Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ., 2FESC, RIEM, Nagoya Univ. Grad. Sch. Med., 3Dept. Neuropsychopharmacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 4Comparative Cognitive Sci., Institutes & Dept. Chem. Pharmacol., Meijo Univ., Grad. Sch. Pharmaceu. Sci.
Journal of Pharmacological Sciences 118 (suppl) 38-38, 2012.

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S3M-26-3 Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus

Hiroyuki Mizoguchi1, Jun Sato1, Kiyofumi Yamada2
1Fut. Environ. Sim. Center, Res. Inst. Environ. Med., Nagoya Univ., 2Dep. Neuropsychopharmacol. and Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 38-38, 2012.

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S3M-26-4 Role of neuropsin in learning and memory

Yasuyuki Ishikawa, Hideki Tamura, Sadao Shiosaka
Laboratory of Functional Neuroscience, Nara Institute of Science and Technology
Journal of Pharmacological Sciences 118 (suppl) 38-38, 2012.

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S3A-27-1 EP4 and CX3CR1 regulate both immune and pain responses in mice

Kenzo Muramoto
Tsukuba research laboraroties, Eisai Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 39-39, 2012.

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S3A-27-2 New methodologies in drug discovery research for analgesic agents： Automated measurement of spontaneous pain-associated animal behaviors for alignment of preclinical/clinical endpoints

Yukinori Nagakura, Go Ishikawa, Sachiko Kawasaki-Yatsugi, Hiroyuki Ito
Pharmacology Research Labs, Drug Discovery Research, Astellas Pharma Inc.
Journal of Pharmacological Sciences 118 (suppl) 39-39, 2012.

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S3A-27-3 Discovery of voltage-gated sodium channel blockers for the treatment of neuropathic pain

Shuzo Watanabe
RaQualia Pharma Inc.
Journal of Pharmacological Sciences 118 (suppl) 39-39, 2012.

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S3A-27-4 Novel therapeutic approach to neuropathic pain ： "Hot" and "Cool" TRP channel family

Tatsuya Kamei, Masanori Miyauchi, Yoshihiro Oyamada, Isao Shimizu
Pharmacol. Research lab., Dainippon Sumitomo Pharma Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 39-39, 2012.

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S3D-28-1 An analysis on the expression and function of dopamine receptor subtypes in midbrain nucleus substantia nigra

Katsuya Yamada
Dept. Physiol., Hirosaki Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 40-40, 2012.

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S3D-28-2 Simultaneous recordings of neuronal activities and dopamine release from single dopaminergic neurons in rat the midbrain

Toshihiko Momiyama
Dept. Pharmacol., Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 40-40, 2012.

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S3D-28-3 Postnatal development of intrinsic tyrosine hydroxylase mRNA-expressing neurons in the striatum

Toshihiko Aosaki, Masao Masuda, Masami Miura, Ritsuko Inoue
Neuropathophysiol. TMIG
Journal of Pharmacological Sciences 118 (suppl) 40-40, 2012.

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S3D-28-4 Control of instrumental learning through striatal projection pathways

Kazuto Kobayashi
Dept. Mol. Genet., Fukushima Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 40-40, 2012.

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S3D-28-5 Effect of antidepressants on the function of dentate gyrus： possible roles for dopamine D1 receptors

Akinori Nishi
Dept. Pharmacol., Kurume Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 41-41, 2012.

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S3E-29-1 Development of novel therapeutic strategies for inner ear diseases

Takayuki Nakagawa
Dept. Otolaryngol., Kyoto Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 42-42, 2012.

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S3E-29-2 Drug and gene delivery into inner ear

Sho Kanzaki
Dept. Otolaryngol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 42-42, 2012.

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S3E-29-3 Cell therapy for hereditary hearing loss with stem cell homing factors

Kazusaku Kamiya, Katsuhisa Ikeda
Dept. of Otorhinolarygol., Juntendo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 42-42, 2012.

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S3E-29-4 In vitro induction system to generate mechanosensitive hair cell-like cells from ES and iPS cells

Kazuo Oshima
Stanford Univ., Dept. of Otolaryngology
Journal of Pharmacological Sciences 118 (suppl) 42-42, 2012.

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S3A-30-1 Genetic polymorphisms associated with oxaliplatin-induced chronic peripheral neurotoxicity

Yuichi Ando
Dept. Clin. Oncol. Chemother., Nagoya Univ. Hosp.
Journal of Pharmacological Sciences 118 (suppl) 43-43, 2012.

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S3A-30-2 Evidence from basic studies on mechanisms and treatment drugs for oxaliplatin-induced peripheral neuropathy

Nobuaki Egashira, Takehiro Kawashiri, Ryozo Oishi
Dept. Pharmacy, Kyushu Univ. Hosp.
Journal of Pharmacological Sciences 118 (suppl) 43-43, 2012.

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S3A-30-3 Role of satellite cell-derived L-serine in the dorsal root ganglion in paclitaxel-induced painful peripheral neuropathy

Tomoyuki Kawamata
Dept. Anesthesiol., Shinshu Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 43-43, 2012.

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S3A-30-4 Sensitization of TRPA1 contributes to oxaliplatin-induced acute cold hypersensitivity

Takayuki Nakagawa, Meng Zhao, Hisashi Shirakawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharmaceu. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 43-43, 2012.

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S3A-30-5 Therapeutic strategy targeting Cav3.2 T-type calcium channels for cancer chemotherapy-induced neuropathic pain

Atsufumi Kawabata
Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 44-44, 2012.

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S3D-31-1 Control of neuronal death through nicotinic ACh receptor in neurodegenerative disorders

Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Scis
Journal of Pharmacological Sciences 118 (suppl) 45-45, 2012.

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S3D-31-2 Role of nicotinic receptor signaling in neuroprotection

Yuki Takada-Takatori1, Toshiaki Kume2, Akinori Akaike2
1Dept. Pharmacol., Fac. Pharm. Sci., Doshisha Momen's College, 2Dept. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 45-45, 2012.

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S3D-31-3 Involvement of nicotinic acetylcholine receptors in the regulation of microglial glutamate transporters

Norimitsu Morioka, Yoshihiro Nakata
Dept. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 45-45, 2012.

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S3D-31-4 Analysis of central nicotinic receptor-mediated neuronal function with in vivo molecular imaging technique

Hideo Saji1, Masashi Ueda2
1Graduate Sch. Pharm. l Sci, Kyoto Univ., 2Radioisotopes Res. Lab., Kyoto Univ. Hospital, Fac. Med., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 45-45, 2012.

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S3E-32-1 Allergens and their Th2 adjuvant activity

Toshiro Takai
Atopy (Allergy) Research Center, Juntendo Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 46-46, 2012.

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S3E-32-2 Genome-wide association studies of allergic diseases

Mayumi Tamari, Tomomitsu Hirota
Lab. for Respiratory Dis., CGM, RIKEN
Journal of Pharmacological Sciences 118 (suppl) 46-46, 2012.

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S3E-32-3 Airway inflammation and responsiveness in mice sensitized via the skin

Koichiro Asano
Pulmonary Div., Keio Unive Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 46-46, 2012.

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S3E-32-4 House dust mite-induced airway eosinophilic inflammation -Involvement of toll-like receptors-

Hiroyuki Tanaka1, 2, Naoki Inagaki1, 2
1Lab. Pharmacol., Dept. Biofunctional Mol., Gifu Pharm. Univ., 2United Grad. Sch. Drug Disc. Med. Inform. Sci., Gifu Univ.
Journal of Pharmacological Sciences 118 (suppl) 46-46, 2012.

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S3E-32-5 Neutrophilic airway inflammation in experimental asthma -Regulation by IL-10-producing Tr1 cells-

Takeshi Nabe
Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 47-47, 2012.

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S3A-33-1 Exosome-delivered microRNAs in cancer development

Takahiro Ochiya
Div. Mol. Cell. Med.
Journal of Pharmacological Sciences 118 (suppl) 48-48, 2012.

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S3A-33-2 Epigenetic and post-transcriptional mechanisms of chronic pain and stress

Minoru Narita
Dept. Pharamcol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 48-48, 2012.

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S3A-33-3 Disease-specific iPSC research for the exploration of pathomechanisms of intractable neurodegenerative diseases

Haruhisa Inoue1, 2
1CiRA, Kyoto University, 2Japan Science and Technology Agency, CREST
Journal of Pharmacological Sciences 118 (suppl) 48-48, 2012.

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S3A-33-4 Regeneration of the damaged CNS using human iPSCs-derived neural progenitor cells

Hideyuki Okano
Dept. Physiology, Keio Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 48-48, 2012.

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S3D-34-1 ALS from the view of the genes

Hideshi Kawakami
Dept. Epidemiol, Hiroshima Univ. RIRBM
Journal of Pharmacological Sciences 118 (suppl) 49-49, 2012.

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S3D-34-2 Pathogenesis and treatment strategy for amyotrophic lateral sclerosis targeting 4-hydroxynonenal, an aldehydic product of membrane lipid peroxidation

Yoshihisa Ito1, Yasuhiro Kosuge1, Hiroko Miyagishi1, Shin-ichi Ono2, Takashi Suzuki2, Kumiko Ishige1
1Lab., of Pharmacol., Sch., of Pharm., Nihon Univ., 2Lab., of Clin. Med, Sch., of Pharm., Nihon Univ.
Journal of Pharmacological Sciences 118 (suppl) 49-49, 2012.

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S3D-34-3 The discovery of biomarkers for ALS diagnosis

Hirotaka Tanaka, Hideaki Hara
Mol. Pharmacol. Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 118 (suppl) 49-49, 2012.

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S3D-34-4 Development of therapy in amyotrophic lateral sclerosis using hepatocyte growth factor

Masashi Aoki
Dept. Neurology, Tohoku Univ. Scl. Med
Journal of Pharmacological Sciences 118 (suppl) 49-49, 2012.

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S3E-35-1 5-HT-related therapeutic agents for gastrointestinal diseases： antiemetics, prokinetics and anti-IBS drugs.

Toshihide Yokoyama, Takuya Hirata, Yoshihiro Keto, Mayumi Yamano
Applied Pharmacol. Res. Labs., Astellas Pharma
Journal of Pharmacological Sciences 118 (suppl) 50-50, 2012.

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S3E-35-2 Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice

Kenjiro Matsumoto, Kimihito Tashima, Syunji Horie
Dept. Pharmacol, Josai Int. Univ.
Journal of Pharmacological Sciences 118 (suppl) 50-50, 2012.

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S3E-35-3 Pro-inflammatory action of serotonin via activation of 5-HT3 receptors in the gut

Shinichi Kato, Masashi Yasuda, Michiko Yamashita, Masahiro Kojo, Kikuko Amagase, Koji Takeuchi
Div. Pathol. Sci., Dept. Pharmacol. Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 50-50, 2012.

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S3E-35-4 5-HT4 receptor-mediated anti-inflammatory potency via nAChR in digestive irritation.

Masatoshi Hori1, Yasuaki Tsuchida1, 2, Masahiko Fujisawa3, Fumihiko Hatao2, Takahisa Murata1, Yasuyuki Seto2, Hiroshi Ozaki1
1Dept. of Vet. Pharmacol., Grad. Sch. of Agri. & Life Sci., The Univ. of Tokyo, 2Dept. of Gastro. Surg., Grad. Sch. of Med., The Univ. of Tokyo, 3Dept. of Ani. Sci., Nippon Vet. Life Sci. Univ.
Journal of Pharmacological Sciences 118 (suppl) 50-50, 2012.

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S3E-35-5 In vitro neural differentiation and in vivo neural regeneration and neurogenesis promoted by 5-HT4 receptor (SR4) activation

Miyako Takaki1, Hiromi Misawa1, Hiroko Matsuyoshi1, Isao Kawahara1, Kei Goto1, Koji Obata1, Hiroki Kuniyasu2
1Dept. Physiol. II, Nara Med. Univ., 2Dept. Mol. Pathophysiol., Nara Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 51-51, 2012.

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S3A-36-1 Principle of Regulatory Science

Mitsuru Uchiyama
Council on Pharmacists Credentials
Journal of Pharmacological Sciences 118 (suppl) 52-52, 2012.

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S3A-36-2 Regulatory science for the safety evaluation to risk assessment/management in non-clinical drug research and development

Ikuo Horii1, 2
1Pfizer Japan Inc., Shinjuku Bunka Quint Bldg., 2Showa Univ.
Journal of Pharmacological Sciences 118 (suppl) 52-52, 2012.

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S3A-36-3 Consideration of Regulatory Science for Supporting the Development of Innovative Drugs

Toru Kawanishi
Natl. Inst. Health Sci.
Journal of Pharmacological Sciences 118 (suppl) 52-52, 2012.

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S3A-36-4 Apply of regulatory science on food safety evaluation

Yasushi Yamazoe
Div. Drug Metab. & Mol. Toxicol.
Journal of Pharmacological Sciences 118 (suppl) 52-52, 2012.

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S3D-37-1 The Forefront of Endoplasmic Reticulum Stress Research

Kazutoshi Mori
Dept. Biophys., Grad. Sch. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 53-53, 2012.

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S3D-37-2 The roles of unfolded protein response in osteogenesis and chondrogenesis

Kazunori Imaizumi
Dept. Biochem., Hiroshima University
Journal of Pharmacological Sciences 118 (suppl) 53-53, 2012.

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S3D-37-3 ER quality control of disease-associated ABC Transporters

Tsuyoshi Shuto1, 2, Shingo Suzuki1, 2, Takashi Sato1, 2, 3, Takashi Sugiyama1, 2, Masayuki Kaneko4, Tappei Takada5, Hiroshi Suzuki5, Hiroyuki Kusuhara6, Yuichi Sugiyama6, Mary Ann Suico1, 2, Hirofumi Kai1, 2
1Dept. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ., 2G-COE “Cell Fate Reg. Res. Edu. Unit”, Kumamoto Univ., 3Cell Sci., Fukushima Med. Univ. Sch. Med, 4Dept. Pharmacol., Fac. Pharm. Sci., Chiba Inst. Sci., 5Dept. Pharm., Univ. Tokyo Hosp., Fac. Med., The Univ., 6Lab. Mol. Pharmacokinet., Grad. Sch. Pharm. Sci., The Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 53-53, 2012.

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S3D-37-4 Possible involvement of endoplasmic reticulum protein degradation in Alzheimer's disease

Masayuki Kaneko1, Yasunobu Okuma1, Yasuyuki Nomura2
1Dept. Pharmacol., Fac. Pharmaceut. Sci., Chiba Inst. of Sci., 2Lab. Pharmacother., Yokohama Col. of Pharm.
Journal of Pharmacological Sciences 118 (suppl) 53-53, 2012.

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S3E-38-1 Research on Stress Measurement Biochip for a Single Drop of Saliva

Shin-ichi Wakida
Health Res. Inst., AIST
Journal of Pharmacological Sciences 118 (suppl) 54-54, 2012.

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S3E-38-2 Assessment of salivary membrane transporters including aquaporin as markers of stress-induced xerostomia

Yasuko Ishikawa
Dept. Pharmacol., Tokushima Univ. Grad. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 54-54, 2012.

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S3E-38-3 Withdrawal stress and benzodiazepines potentiate GABA(A)-like receptor function by upregulating steroidogenesis to induce xerostomia

Mitsuru Kawaguchi1, Takashi Shinomiya1, 2, Migiwa Okubo1, 2, Eri Tsukagoshi1, Kohei Sawaki1
1Dept. Pharmacol., Tokyo Dent. Coll., 2OHSChrc8, Tokyo Dent. Coll.
Journal of Pharmacological Sciences 118 (suppl) 54-54, 2012.

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S3E-38-4 Mental stress and descending neural control to the superior salivatory nucleus

Ryuji Matsuo
Dept. OralPhysiol., Okayama Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 54-54, 2012.

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S3E-38-5 Oral mucositis resulting fron irradiatioin

Masanobu Yoshikawa
Dept. Clinical Pharmacol., Tokai Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 55-55, 2012.

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SP1 Practical application of iPS cell technology, roles of industry and university

Hirokazu Yamamoto1, 2
1Office of Society-Academia Collaboration for Innovation, Kyoto University, 2Public Health, Graduate School of Medicine, Kyoto University
Journal of Pharmacological Sciences 118 (suppl) 58-58, 2012.

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SP2 High Purity Human Induced Pluripotent Stem Cell-derived Cardiomyocytes

Craig T. January
University of Misconsin-Madison
Journal of Pharmacological Sciences 118 (suppl) 58-58, 2012.

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O1B1-1-1 Chaperone-mediated autophagy contributes to the survival of neuronal cells under hypoxic conditions

Eisuke Dohi1, 2, Shigeru Tanaka1, 2, Takahiro Seki1, Tatsuhiro Miyagi2, Tetsuya Takahashi2, Izumi Hide1, Masayasu Matsumoto2, Norio Sakai1
1Dept of Mol and Pharm Neurosci, Hiroshima Univ Sch of Biomed Sci, 2Dept of Clin Neurosci and Ther, Hiroshima Univ Sch of Biomed Sci
Journal of Pharmacological Sciences 118 (suppl) 60-60, 2012.

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O1B1-1-2 TRPM2 channel contributes to the progression of ischemic brain injury in mice

Shinya Sakimoto, Hisashi Shirakawa, Masaya Munakata, Takayuki Nakagawa, Syuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 60-60, 2012.

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O1B1-1-3 High Mobility Group Box-1 is Translocated from Nuclei into Peroxisomes/Mitochondria in Neurons after Ischemic Insult

Yusuke Fukuyasu, Keyue Liu, Hidenori Wake, Yoshito Nishimura, Kiyoshi Teshigawara, Masahiro Nishibori
Dept. Pharmacol., Okayama Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 60-60, 2012.

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O1B1-1-4 Involvement of hypothalamic orexin-A and/or BDNF in the development of post-ischemic glucose intolerance and neuronal damage

Shinichi Harada, Wakako Fujita-Hamabe, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 60-60, 2012.

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O1B1-1-5 Mesenchymal stem cells transmigrate across the blood-brain barrier through transiently formed interendothelial gaps

Takahiro Katayama1, Tatsuya Kibayashi1, Takashi Matsushita1, 2, Osamu Honmou3, Shun Shimohama2, Masabumi Minami1
1Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ., 2Dept. Neurol., Sch. Med., Sapporo Med. Univ., 3Dept. Neural Rep. and Ther., Sch. Med., Sapporo Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 61-61, 2012.

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O1B1-2-1 V-1 regulates tyrosine hydroxylase gene expression via SRF-mediated transcription coupled with actin polymerization

Ichiro Kawahata1, Junichi Morita1, Akiko Tabuchi2, Masaaki Tsuda2, Hiroshi Ichinose3, Yasuhiko Izumi4, Toshiaki Kume4, Akinori Akaike4, Tohru Yamakuni1
1Division of Pharmacotherapy, Grad. Sch. of Pharm., Tohoku Univ., 2Division of Mol. Neurobiol., Grad. Sch. of Pharm., Toyama Univ., 3Grad. Sch. of Biosci. and Biotech., Tokyo Tech, 4Dept. Pharmacol., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 61-61, 2012.

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O1B1-2-2 Amyloid-like fibril of GAPDH enhances aggregation and neurotoxicity of α-synuclein

Takeya Kubo1, Yuko Semi1, Hidemitsu Nakajima1, Hisao Tajima2, Yasu-Taka Azuma1, Tadayoshi Takeuchi1
1Lab. of Veterinary Pharmacology, Osaka Pref. Univ., 2Ono Pharmaceutical Co.,Ltd
Journal of Pharmacological Sciences 118 (suppl) 61-61, 2012.

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O1B1-2-3 [18F]THK-523 for In vivo imaging of Tau pathology in Alzheimer's disease

Ryuichi Harada1, Nobuyuki Okamura1, Shozo Furumoto1, Takeo Yoshikawa1, Hiroyuki Arai2, Kazuhiko Yanai1, Yukitsuka Kudo3
1Dept. Pharmacol., Tohoku Univ. Sch. Med., 2Dept. Geriatrics and Gerontology., Tohoku Univ. Sch. Med., 3Innovation of New Biomedical Engineering Center, Tohoku Univ.
Journal of Pharmacological Sciences 118 (suppl) 61-61, 2012.

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O1B1-2-4 Aβ generation is reduced by decreased expression of ubiquitin ligase RNF19B

Masashi Yamamori1, Masayuki Kaneko1, Masayuki Onoguchi1, Yasuyuki Nomura2, Yasunobu Okuma1
1Dept. Pharmacol., Chiba Inst Sci., 2Lab. Pharmacotherapeutics, Yokohama Col. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 62-62, 2012.

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O1B1-2-5 A novel Alzheimer disease therapeutics, ST101 improves cognition via increased ACh release in the hippocampus.

Yui Yamamoto1, Norifumi Shioda1, Feng Han2, Shigeki Moriguchi1, Kohji Fukunaga1
1Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci., 2Zhejiang University
Journal of Pharmacological Sciences 118 (suppl) 62-62, 2012.

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O1B1-2-6 Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid β

Naotaka Izuo1, Toshiaki Kume1, Mizuho Sato2, Kazuma Murakami2, Kazuhiro Irie2, Yasuhiko Izumi1, Akinori Akaike1
1Dept. Pharmacol, Kyoto Univ., 2Dept. Food Sci. and Biotech., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 62-62, 2012.

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O1B1-3-1 Macrophage inflammatory proteins produce peripheral neuroinflammation leading to neuropathic pain

Norikazu Kiguchi, Yuka Kobayashi, Shiroh Kishioka
Dept. Pharmacol., Wakayama Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 62-62, 2012.

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O1B1-3-2 LPA-induced amplification of LPA biosynthesis through activation of LPA3 receptor and microglia-advanced findings with LPA measurement using MALDI-TOF-MS analysis

Lin Ma, Hiroshi Ueda
Div. Mol. Pharmacol. & Neurosci. Nagasaki Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 63-63, 2012.

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O1B1-3-3 Potassium buffering in an astrocyte model

Shingo Murakami, Yoshihisa Kurachi
Dept. Pharmacol., Osaka Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 63-63, 2012.

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O1B1-3-4 Ocular albinism-1 (OA-1) is a G-protein coupled receptor that mediates L-DOPA-induced depressor and bradycardic responses in rat nucleus tractus solitarii

Yoshio Goshima1, Fumio Nakamura1, Yukihiko Hiroshima2, Hirosi Miyamoto2, Naoya Yamashita1, Itaru Endou2
1Dept. Mol Pharmacol & Neurobiol., Grad. Sch. of Med., Yokohama City Univ., 2Dept. Gastroenterol. Surgery, Grad. Sch. of Med., Yokohama City Univ.
Journal of Pharmacological Sciences 118 (suppl) 63-63, 2012.

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O1B1-4-1 TRPA1 channel-mediated microdomains contribute to resting calcium levels in astrocytes.

Eiji Shigetomi1, Kelvin Y Kwan3, David P. Corey3, Baljit S. Khakh1, 2
1Dept. Physiol., David Geffen Sch. Med., UCLA, 2Dept. Neurobiol., David Geffen Sch. Med., UCLA, 3HHMI, Dept. Neurobiol., Harvard Med. Sch.
Journal of Pharmacological Sciences 118 (suppl) 63-63, 2012.

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O1B1-4-2 Predominant role of PMAT in histamine uptake by normal human astrocytes

Takeo Yoshikawa, Fumito Naganuma, Tadaho Nakamura, Tomomitsu iida, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 64-64, 2012.

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O1B1-4-3 A general anesthetic Propofol enhances inhibitory effect of zinc on AQP4

Jungo Kato1, Yoshinori Yukutake2, Mariko Hayashi3, Masato Yasui3
1Dept. Anesthesiol. Keio Univ. Grad. Sch. Med., 2Dept. Biochem. Keio Univ. Sch. Med., 3Dept. Pharmacol. Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 64-64, 2012.

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O1B1-4-4 Effect of antidepressants on the functional impairment of L-glu transporters under the inflammatory condition

Koki Fujimori1, Junpei Takaki1, 2, Kaoru Sato2, Takeshi Suzuki1
1Div. Basic Biol. Sci., Fac. Pharm., Keio Univ., 2Div. Pharmacol., NIHS
Journal of Pharmacological Sciences 118 (suppl) 64-64, 2012.

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O1B1-4-5 Contribution of astrocyte endfeet to diffusion barrier functions at the blood-brain interface

Mutsuo Nuriya, Masato Yasui
Dept. Pharmacol., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 64-64, 2012.

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O1B1-5-1 Analgesic effects of a novel amphiphilic ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate, as an ointment in rats with neuropathy induced by L5 spinal nerve cutting

Kazumasa Okubo1, Hiroki Nakanishi1, Maho Matsunami1, Hiroharu Shibayama2, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm., 2HBC Science Laboratory Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 65-65, 2012.

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O1B1-5-2 The crosstalk between macrophages and T-lymphocytes plays a crucial role in neuropathic pain.

Yuka Kobayashi1, Norikazu Kiguchi1, Takehiko Maeda2, Siroh Kishioka1
1Dept. Pharmacol., Wakayama Med. Univ., 2Dept. Pharmacol., Niigata Univ. of Pharm. Applied Life Sci.
Journal of Pharmacological Sciences 118 (suppl) 65-65, 2012.

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O1B1-5-3 Paclitaxel-induced lysophosphatidic acid-1 receptor signaling causes demyelination and neuropathic pain

Ryo Yano, Hiroshi Ueda
Div. Mol. Pharmacol. & Neurosci. Nagasaki Univ. Grad. Sch. of Biomed. Sci
Journal of Pharmacological Sciences 118 (suppl) 65-65, 2012.

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O1B1-5-4 Mechanism for preemptive anti-neuropathic pain treatment-prevention of injury-induced LPA production by opioid-induced medullo-spinal descending suppression of intense pain

Jun Nagai, Hiroshi Ueda
Div. Mol. Pharmacol. & Neurosci. Nagasaki Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 65-65, 2012.

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O1B1-5-5 The role of basolateral and basomedial nucleus of amygdala in the fear expression and extinction learning.

Taiju Amano, Sevil Duvarci, Daniela Popa, Denis Pare
CMBN, Rutgers Univ.
Journal of Pharmacological Sciences 118 (suppl) 66-66, 2012.

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O1B2-1-1 GluRδ2 induces tetramerization of Neurexins to Trigger Synapse Formation

Sung-Jin Lee, Takeshi Uemura, Tomoyuki Yoshida, Masayoshi Mishina
Dept. of Mol. Neurobiol. & Pharmacol., Grad. Sch. of Med., Univ. of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 66-66, 2012.

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O1B2-1-2 Development of a glutamate imaging technique with a single synapse resolution in brain slices

Tetsuro Ariyoshi, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 66-66, 2012.

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O1B2-1-3 Mechanism of type 1 IO3 receptors (IP3Rs-1) up-regulation via dopamine receptor

Koji Mizuno, Kazuhiro Kurokawa, Seitaro Ohkuma
Dept. Pharmacol., Kawasaki Med Sch.
Journal of Pharmacological Sciences 118 (suppl) 66-66, 2012.

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O1B2-1-4 Equilibrative nucleoside transporter 1-mediated uptake of adenosine regulates the proliferation and differentiation of mouse hippocampal neural stem cells

Aya Hariu1, Yuko Suzuki1, Takahiro Moriya1, Sun Choi2, Doo-Sup Choi2, Norimichi Nakahata1
1Dept. Cell Signal, Grad Sch Pharm Sci, Tohoku Univ, 2Molecular Pharmacology, Mayo Clinic College of Medicine
Journal of Pharmacological Sciences 118 (suppl) 67-67, 2012.

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O1B2-1-5 Involvement of pyrophosphatase1 in neuronal differentiation

Yu Tezuka, Yuka Tada, Hideo Nishigori, Atsushi Sanbe
Dept. Pharmacotherapeutics, Iwate Med. Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 67-67, 2012.

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O1B2-2-1 Prenatal treatment with phencyclidine impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex.

Kazuya Toriumi1, 2, Akihiro Mouri1, 3, Shiho Narusawa1, Yuki Aoyama1, Natsumi Ikawa1, Lingling Lu1, 2, Taku Nagai3, Takayoshi Mamiya1, 2, Toshitaka Nabeshima1, 2
1Dept. Chem. Pharmacol., Meijo Univ. Grad. Sch. Pharmaceutical Sci., 2Comp. Cognit. Sci. Inst. Meijo Univ., 3Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 67-67, 2012.

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O1B2-2-2 Sex differences in behavioral abnormalities and cortical pathology in mice prenatally exposed to valproic acid

Yuta Hara1, Shunsuke Kataoka1, Yuko Maeda1, Yukio Ago1, Kazuhiro Takuma1, Toshio Matsuda1, 2
1Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2United Grad. Sch. of Child Dev., Grad. Sch. of Med., Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 67-67, 2012.

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O1B2-2-3 Riluzole produces distinct anxiolytic-like effects in rats through blockade of voltage-activated sodium channels

Azusa Sugiyama1, 2, Akiyoshi Saitoh1, 2, Misa Yamada1, Takashi Iwai1, 2, Tomio Hashimoto1, Yuya Makino1, 2, Masanori Ohashi1, 2, Sachie Hamada1, 2, Jun-Ichiro Oka1, 2, Masatoshi Inagaki1, Mitsuhiko Yamada1, 2
1Department of Neuropsychopharmacology, National Institute of Mental Health, National Center of Neurology and Psychiatry, 2Laboratory of Pharmacology, Faculty of Pharmaceutical Science, Tokyo University of Science
Journal of Pharmacological Sciences 118 (suppl) 68-68, 2012.

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O1B2-2-4 Biological mechanism in antidepressant-like effect of sodium butyrate (HDAC inhibitor)

Yosuke Yamawaki1, 2, Manabu Fuchikami2, Shigeru Morinobu2, Masahiro Segawa2, Tomoya Matsumoto2, Koichiro Ozawa1, Shigeto Yamawaki2
1Dept. Pharmacother., Sch. Biomed. Sci., Hiroshima Univ., 2Dept. Psychiat. & Neurosci., Sch. Biomed. Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 68-68, 2012.

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O1B2-2-5 Interference of two distinct associative memories

Koichi Hashikawa, Norio Matsuki, Hiroshi Nomura
Lab. of Chem. Pharmacol., Grad. Sch. Pharm., Univ. of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 68-68, 2012.

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O1B2-3-1 Functional impact of Munc18-1 on gating properties of voltage-dependent Ca2+ channels.

Yoshinori Takada1, Yoshitsugu Uriu1, Hiroshi Nakajima1, Shigeki Kiyonaka1, 2, Yasuo Mori1, 2
1Dept. Synthet. Chem. & Biol. Chem., Kyoto Univ. Grad. Sch. Engn., Kyoto University, Katsura Campus, 2Dept. Technol. & Ecol., Kyoto Univ., Kyoto University, Katsura Campus
Journal of Pharmacological Sciences 118 (suppl) 68-68, 2012.

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O1B2-3-2 Activation of TRPA1 channels by transnitrosylating reagents

Daisuke Kozai1, Maximilian Ebert1, Fumika Karaki2, Yuko Otani2, Yoji Kabasawa2, Nobuaki Takahashi1, Tomohiro Numata1, 3, Shigeki Kiyonaka1, 3, Tomohiko Ohwada2, Yasuo Mori1, 3
1Kyoto Univ, Dept Synthet Chem & Biol Chem, Grad Sch Engn, Kyoto University, Katsura Campus, 2Tokyo Univ, Dept Med Chem, Grad Sch Pharm Sci, 3Kyoto Univ, Dept Technol & Ecol
Journal of Pharmacological Sciences 118 (suppl) 69-69, 2012.

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O1B2-3-3 Stimulation of TRPV4 channel suppresses abnormal activation of microglia induced by lipopolisaccharide

Masakazu Konno1, Hisashi Shirakawa1, Takahito Miyake1, Shota Iida1, Takayuki Nakagawa1, Koji Shibasaki2, Shuji Kaneko1
1Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ., 2Dept. Mol. Cell. Neurol., Grad. Sch. Med., Gumma Univ.
Journal of Pharmacological Sciences 118 (suppl) 69-69, 2012.

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O1B2-3-4 Inverse agonist-like action of cadmium on G-protein-gated inward rectifier K+ channels

Atsushi Inanobe1, Atsushi Nakagawa2, Yoshihisa Kurachi1
1Dept. Pharmacol., Osaka Univ., Grad. Sch. Med., 2Inst. for Protein Res., Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 69-69, 2012.

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O1B2-3-5 Hyperpolarization-activated Cyclic Nucleotide-gated Channels in rat pineal gland

Keiko Kiyota, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept Mol & Cell Pharmacol, Grad Sch Pharmaceut Sci, Nagoya City Univ.
Journal of Pharmacological Sciences 118 (suppl) 69-69, 2012.

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O1B2-4-1 ERK5 regulates osteoblast differentiation but not osteoclast differentiation

Yoshifumi Takahata, Eiichi Hinoi, Yukio Yoneda
Lab, Mol, Pharmacol., Kanazawa Univ. Grad. Sch. Nat, Sci, Tech
Journal of Pharmacological Sciences 118 (suppl) 70-70, 2012.

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O1B2-4-2 Enhancement of expression of Ca2+ -release-activated Ca2+ channel on human T cells in rheumatoid arthritis

Shuang Liu1, Shouhei Watanabe2, Kazutaka Maeyama1
1Dept. Pharmacol. Infomational Biomed. Ehime Univ. Sch. Med., 2Dept. Bone and Joint Surgery, Ehime Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 70-70, 2012.

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O1B2-4-3 Dynamic in vivo imaging of bone-resorptive functions of mature osteoclasts in live bones by using intravital multiphoton microscopy

Junichi Kikuta1, 2, Yoh Wada3, Masaru Ishii1, 2
1Lab. Cellular Dynamics, IFReC, Osaka Univ., 2JST, CREST, 3ISIR, Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 70-70, 2012.

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O1B2-4-5 High fat diet-induced inflammation in adipose tissues is reduced in adipocyte-specific hypoxia-inducible factor-1α Knockout mice.

Manami Hirata1, Yoshitaka Kihira1, Mariko Miyake2, Yuki Izawa-Ishizawa1, Keisuke Ishizawa2, Yasumasa Ikeda1, Koichiro Tsuchiya2, Toshiaki Tamaki1, Shuhei Tomita1
1Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima. Grad. Sch., 2Dept. medical Pharmacol., Inst. Health Biosciences, Univ. Tokushima. Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 71-71, 2012.

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O1B2-5-1 Mitochondrial reactive oxygen species contribute to vancomycin-induced renal tubular cell apoptosis

Takahisa Yano1, Megumi Hirano2, Yuya Sakamoto2, Yohei Arimura1, Yuki Ushijima2, Nobuaki Egashira1, 2, Ryozo Oishi1, 2
1Dept. Pharmacy, Kyushu Univ. Hosp., 2Fac. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 71-71, 2012.

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O1B2-5-2 Pirfenidone prevents the progression of renal injury in Dahl salt-sensitive rat

Xu Ji, Yukiko Naito, Xiao Ma, Huachun Weng, Kosuke Endo, Naoharu Iwai
Dept. Genom Med., NCVC.
Journal of Pharmacological Sciences 118 (suppl) 71-71, 2012.

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O1B2-5-3 p21 is central regulator for the development of cell senescence in diabetic proximal tubules

Kento Kitada1, Daisuke Nakano1, Junichi Yatabe2, Hirofumi Hitomi1, Hiroyuki Kobori1, Akira Nishiyama1
1Dept. Pharmacol., Kagawa Univ., 2Dept. Pharmacol., Fukushima Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 71-71, 2012.

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O1B2-5-4 Establishment of a human-disease model mouse for Japanese-type cystinuria

Yasuharu Kawamoto1, 2, Shushi Nagamori2, Pattama Wiriyasermkul2, Kenichiro Iio2, Yoshikatsu Kanai2
1Osaka Univ. Facul. Med., 2Bio-system Pharmacol., Osaka Univ. Grad Sch Med.
Journal of Pharmacological Sciences 118 (suppl) 72-72, 2012.

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O1B2-5-5 The effect of Olmesartan for overactive bladder in spontanously hypertensive rats

Harunori Oiwa, Motoaki Saito, Fumiya Ohmasa, Seiya Inoue, Panagiota Tsounapi, Keisuke Satoh
Div. of Mol. Pharmacol., Tottori Univ. Faculty of Med.
Journal of Pharmacological Sciences 118 (suppl) 72-72, 2012.

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O1C1-1-1 Involvement of impaired endoplasmic reticulum stress response in the development of hepatic insulin resistance in orexin knockout mice

Emi Tokai, Hiroshi Tsuneki, Yuya Nakamura, Keisuke Takahashi, Mikio Fujita, Tsutomu Wada, Toshiyasu Sasaoka
Dept. Clin. Pharmacol., Univ. of Toyama
Journal of Pharmacological Sciences 118 (suppl) 72-72, 2012.

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O1C1-1-2 SIRT1 activation by resveratrol ameliorates dystrophic muscle pathology in mdx mice

Yusuke Hori1, Atsushi Kuno1, 2, Ryusuke Hosoda1, Masaya Tanno2, Tetsuji Miura2, Kazuaki Shimamoto2, Yoshiyuki Horio1
1Dept. Pharmacol., Sapporo Med. Univ. Sch. Med., 2Dept. 2nd. Int. Med., Sapporo Med., Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 72-72, 2012.

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O1C1-1-3 Protective effects of luteolin on oxidative stress model induced by microinjection of sodium nitroprusside in mice

Qand Agha Nazari, Yasuhiko Izumi, Toshiaki Kume, Akinori Akaike
Dept. Pharmacol., Gra. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 73-73, 2012.

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O1C1-1-4 Alteration of metabolic response during treadmill exercise in taurine transporter-knockout mice

Takashi Ito, Junichi Azuma
Dept. Pharm., Hyogo Univ. Health Science
Journal of Pharmacological Sciences 118 (suppl) 73-73, 2012.

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O1C1-1-5 Bidirectional roles of brain 2-arachidonoylglycerol in bombesin-induced activation of central sympatho-adrenomedullary outflow in rats

Takahiro Shimizu, Kenjiro Tanaka, Kumiko Nakamura, Kunihiko Yokotani
Dept. Pharmacol., Sch. of Medicine, Kochi Univ.
Journal of Pharmacological Sciences 118 (suppl) 73-73, 2012.

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O1C1-2-1 Axonal ATP signaling mediates Schwann cell myelination

Daisuke Ino1, Kazunori Kanemaru1, Yohei Okubo1, Kuniaki Ishii2, Masamichi Ohkura3, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med. Univ. Tokyo, 2Dept. Cardiovasc. Pharmacol., Yamagata Univ. Sch. Med., 3Brain Sci. Instit., Saitama Univ.
Journal of Pharmacological Sciences 118 (suppl) 73-73, 2012.

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O1C1-2-2 Insulin-induced neurite-like process outgrowth： acceleration of tau protein synthesis via a PI3K～mTOR pathway

Takayuki Nemoto1, Toshihiko Yanagita1, Akihiko Wada2, Manabu Murakami1
1Dept. Pharmacol., Miyazaki Med. Coll., Univ., 2Dept. Sports Health and Welfare, Social Welfare, Kyushu Univ. Hlth. Welfare
Journal of Pharmacological Sciences 118 (suppl) 74-74, 2012.

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O1C1-2-3 Histamine H3 Receptor Regulates the Functions of Pancreatic β-cell

Tadaho Nakamura1, Takeo Yoshikawa1, Naoya Noguchi2, Fumito Naganuma1, Ryuichi Harada1, Attayeb Mohsen1, Tomomitsu Iida1, Atsuko Kasajima3, Hironobu Sasano3, Kazuhiko Yanai1
1Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med., 2Dept. Otorhino., Tohoku Univ. Grad. Sch. Med., 3Dept. Phathol., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 74-74, 2012.

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O1C1-2-4 Role of steroidogenic acute regulatory protein-related lipid transfer domain containing 10 (STARD10) in lipid droplet formation

Masanori Ito, Hiroko Izumi-Nakaseko, Hiroko Maruyama, Atsushi Sugiyama, Satomi Adachi-Akahane
Department of Pharmacology, Faculty of Medicine, Toho University
Journal of Pharmacological Sciences 118 (suppl) 74-74, 2012.

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O1C1-2-5 HPGB, an inhibitor for mitochondrial fusion, promotes mitophagy

Shintaro Higashi1, Norihito Shintani1, Kazuhiko Katagi1, Kazuya Ikeda1, Mai Koumoto1, Natsumi Hiraki1, Atsuko Hayata1, 2, Hitoshi Hashimoto1, 2, 3, Akemichi Baba4
1Grad. Sch. of Phramaceut. Sci., Osaka Univ., 2United Grad. Sch. of Child Development, Osaka Univ., Kanazawa Univ., and Hamamatsu Univ. Sch. of Med., 3Grad. Sch. of Medicine., Osaka Univ., 4Sch. of Pharmacy, Hyogo Univ. of Health Sci.
Journal of Pharmacological Sciences 118 (suppl) 74-74, 2012.

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O1C1-3-1 Inhibition of thromboxane A2 synthase prevents reduction in the antiplatelet effect of a prostaglandin I2 receptor agonist after repeated administration

Hitoshi Kashiwagi1, Koh-ichi Yuhki1, Fumiaki Kojima1, Yoshiki Sakai2, Shuh Narumiya3, Fumitaka Ushikubi1
1Dept. Pharmacol., Asahikawa Med. Univ., 2Research Headquarters, Ono Pharmaceutical Co.,Ltd., 3Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 75-75, 2012.

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O1C1-3-2 FOS induction by emetine via p38 MAPK and RNA-binding protein HuR in human granulocytes

Xiaomin Feng, Yayoi Shikama, Junko Kimura
Dept. of Pharmacol., Inst. of Med., Univ of Fukushima Med.
Journal of Pharmacological Sciences 118 (suppl) 75-75, 2012.

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O1C1-3-3 Is the phenotype manifested by complete PAI-1 deficiency in human compatible to that in mouse?

Takayuki Iwaki, Kazuo Umemura
Dept. Pharmacol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 75-75, 2012.

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O1C1-3-4 Rap1-mediated cAMP signaling is involved in decidualization of human endometrial stromal cells.

Kazuya Kusama, Mikihiro Yoshie, Kazuhiro Tamura, Ayako Hirata, Masahiko Kutsukake, Eiichi Tachikawa
Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.
Journal of Pharmacological Sciences 118 (suppl) 75-75, 2012.

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O1C1-3-5 The role of KATP2 channels on ischemia reperfusion injury in the rat testis

Panagiota Tsounapi1, 2, Motoaki Saito2, Fotios Dimitriadis2, Kazuyuki Kitatani3, Yukako Kinoshita2, Kohei Shomori4, Atsushi Takenaka1, Keisuke Satoh2
1Div. of Urology Dept. of Surgery, Tottori Univ., 2Div. of Mol. Pharmacol. Dept. of Pathophysiological and Therapeutic Sci., Tottori Univ., 3Div. of Clinical Lab., Tottori Univ., 4Div of Organ Pathol., Department of Microbiol and Pathol., Tottori Univ.
Journal of Pharmacological Sciences 118 (suppl) 76-76, 2012.

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O1C1-4-1 Inhibition of ATP Release Suppressed Arrhythmogenicity in Pressure Overloaded Mouse Atrium

Sakiko Oishi1, Tetsuo Sasano2, Tetsushi Furukawa1
1Dept. Bio-informational Pharmacol., MRI, Tokyo Med. & Dent. Univ., 2Dept. Cardiovascular Med., Tokyo Med. & Dent. Univ.
Journal of Pharmacological Sciences 118 (suppl) 76-76, 2012.

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O1C1-4-2 Comparison of disease phenotypes in mouse models of inherited cardiomyopathy on C57Bl/6 and BALB/c backgrounds

Lei Li1, Sachio Morimoto1, Dong-Yun Zhan2, Cheng-Kun Du2, Yuan-Yuan Wang1, Xue-Li Fan1, Tatsuya Yoshihara1, Fumi Takahashi1, Toshiyuki Sasaguri1
1Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ., 2Natl. Cerebral & Cardiovasc. Res. Ctr. Inst.
Journal of Pharmacological Sciences 118 (suppl) 76-76, 2012.

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O1C1-4-3 The ablation of RORγt gene results in advanced cardiac fibrosis after Myocardial Infarction

Tomomi Yamashita, Masanori Obana, Akiko Hayama, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clin. Sci. and Biomed, Grd. Sch.
Journal of Pharmacological Sciences 118 (suppl) 76-76, 2012.

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O1C1-4-4 HDAC4 is a novel candidate factor responsible for development of hypertension in spontaneous hypertensive rats

Tatsuya Usui, Muneyoshi Okada, Wataru Mizuno, Mayuko Oda, Natsuki Ide, Tomoka Morita, Yukio Hara, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med. Sci.
Journal of Pharmacological Sciences 118 (suppl) 77-77, 2012.

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O1C1-4-5 TRIC-A channels regulate blood pressure in vascular smooth muscle

Daiju Yamazaki1, Satomi Kita2, Miyuki Nishi1, Yuji Imaizumi3, Takahiro Iwamoto2, Hiroshi Takeshima1
1Dept. of Biol. Chem., Grad. Sch. of Pharmaceut. Sci., Kyoto Univ., 2Dept. Pharmacol., Faculty of Med., Fukuoka Univ., 3Dept. of Mol. Cell. Phamacol., Grad. Sch. of Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 118 (suppl) 77-77, 2012.

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O1C1-5-1 The inhibitory effects of smooth muscle cell-specific hypoxia-inducible factor-1α deficiency on angiotensin II-induced vascular remodeling in mice

Masaki Imanishi1, Keisuke Ishizawa2, Yoshitaka Kihira1, Yasumasa Ikeda1, Noriko Yamano1, Yuki Ishizawa1, Koichiro Tsuchiya2, Toshiaki Tamaki1, Shuhei Tomita1
1Dept. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch., 2Dept. Med. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 77-77, 2012.

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O1C1-5-2 Identification of Del-1 as an endogenous oxidized LDL inhibitor

Akemi Kakino, Yoshiko Fujita, Tomohide Takaya, Shin Iwamoto, Tatsuya Sawamura
Dept. Vasc. Physiol., Natl. Cereb. Cardiovasc. Ctr. Res. Inst.
Journal of Pharmacological Sciences 118 (suppl) 77-77, 2012.

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O1C1-5-3 Intermittent hypoxia promotes rat vascular muscle cells proliferation with up-regulation of erbB2 receptor and epidermal growth factor family

Yoji Kyotani1, Shin Takasawa2, Hiroyo Ota3, Asako Hironaka2, Akiyo Yamauchi2, Sumiyo Tsuchida2, Jing Zhao1, Hiroshi Kimura3, Satoyasu Ito1, Masanori Yoshizumi1
1Dept. of Pharmacol., Nara Medical University, 2Dept. of Biochem. Nara Medical University, 32nd Dept. of Internal Medicine. Nara Medical University
Journal of Pharmacological Sciences 118 (suppl) 78-78, 2012.

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O1C1-5-4 Oxidative Stress Impairs Desensitization of G-protein Coupled Receptors and Increases Vascular Reactivity in Basilar Artery after Subarachnoid Hemorrhage (SAH)

Katsuharu Kameda1, 2, Yuichiro Kikkawa2, Mayumi Hirano1, Satoshi Matsuo2, Tomio Sasaki2, Katsuya Hirano2
1Div. Mol. Cardiol., Grad. Sch. Med. Sci., Kyushu Univ., 2Dept. Neurosurg., Grad. Sch. Med Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 78-78, 2012.

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O1C1-5-5 M1/M3 acetylcholine receptors mediate acetylcholine-induced endothelium-independent and cgrpergic nerve-mediated vasodilation in rat mesenteric arteries

Panot Tangsucharit1, Poungrat Pakdeechote2, Shingo Takatori1, Fusako Takayama1, Hiromu Kawasaki1
1Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2Department of Physiology, Faculty of Medicine, Khon Kaen University
Journal of Pharmacological Sciences 118 (suppl) 78-78, 2012.

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O1C2-1-1 Hepatic Glut4 expression induced by high sugar and/or high fat diet in rats

Xiao-Jun Li, Jun-xian Wang, Yu-sang Li, Mei-Mei Jia, Min Liu, Yan-Ling Yang, He-Bin Tang
Dept. Pharmacol., S Cent Univ Nationalities, Coll Pharm.
Journal of Pharmacological Sciences 118 (suppl) 78-78, 2012.

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O1C2-1-2 A novel role for hepatocyte NOX1/NADPH oxidase in palmitate-induced apoptosis and insulin resistance.

Jia Zhang, Wenhao Cui, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Pref Univ. Med.
Journal of Pharmacological Sciences 118 (suppl) 79-79, 2012.

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O1C2-1-3 Role of prostaglandin I2 in nonalcoholic steatohepatitis

Shima Kumei2, Koh-ichi Yuhki2, Fumiaki Kojima2, Hitoshi Kashiwagi2, Toshikatsu Okumura1, Shu Narumiya3, Fumitaka Ushikubi2
1Dept. General Med., Asahikawa Med. Univ., 2Dept. Pharmacol., Asahikawa Med. Univ., 3Dept. Pharmacol., Kyoto Univ. Fac. Med.
Journal of Pharmacological Sciences 118 (suppl) 79-79, 2012.

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O1C2-1-4 Novel Redox Polymer Drug-Oral Nanotherapy for Inflammatory Bowel Diseases-

Yukio Nagasaki1, 2, 3, Long Binh Vong1, Toru Yoshitomi1, Hirofumi Matsui2, 4
1Depr. Mat. Sci., Univ. Tsukuba, 2Master's School Med. Sci., U.Tsukuba, 3Satellite Labo. MANA, NIMS, Univ. Tsukuba, 4Dept. GI, Univ. Tsukuba
Journal of Pharmacological Sciences 118 (suppl) 79-79, 2012.

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O1C2-1-5 Pathogenic role of serotonin in 5-fluorouracil-induced intestinal mucositis through activation of 5-HT3 receptors in mice

Masashi Yasuda, Naoki Yamanaka, Maho Iimori, Kikuko Amagase, Shinichi Kato, Koji Takeuchi
Div. of Path. Sci., Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 79-79, 2012.

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O1C2-2-1 Identification of the target molecule of the new anti-allergic compound, maackiain from Kujin

Yuki Nariai1, Hiroyuki Mizuguchi1, Hiroaki Nagai1, Tomoyo Kanayama1, Shuhei Kato1, Yoshiyuki Yoshimura2, Yoshiki Kashiwada3, Hisao Nemoto4, Yoshihisa Takaishi3, Noriaki Takeda5, Hiroyuki Fukui1
1Dept. Mol. Pharmacol., Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch., 2Dept. Med. Pharmacol., Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch., 3Dept. Nat. Med., Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch., 4Dept. Mol. Design and Synthesis., Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch., 5Dept. Otorhinolaryngol. Communicative Neurosci., Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 80-80, 2012.

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O1C2-2-2 PGD2 has opposing roles in the development of dermatitis

Hana Sarashina1, Takahisa Murata1, Yoshiki Tsubosaka1, Kosuke Aritake2, Masatoshi Hori1, Yoshihiro Urade2, Hiroshi Ozaki1
1Department of Veterinary Pharmacology, The University of Tokyo, 2Osaka Bioscience Institute
Journal of Pharmacological Sciences 118 (suppl) 80-80, 2012.

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O1C2-2-3 Shikonin suppresses the activation of mucosal mast cells

Xiaoyu Wang, Shusaku Hayashi, Makoto Kadowaki
Div. of Gastrointestinal Pathophysiology, Inst. of Natural Med., Univ. of Toyama
Journal of Pharmacological Sciences 118 (suppl) 80-80, 2012.

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O1C2-2-4 Resveratrol up-regulates SIRT-1 and abrogates septic lung inflammation and apoptosis in mice

Michinori Takashina, Kengo Tomita, Hiroki Yokoo, Yuichi Hattori
Dept. Mol. Med. Pharmacol., Gradu. Sch. Med. Pharmaceu. Sci., Univ. Toyama
Journal of Pharmacological Sciences 118 (suppl) 80-80, 2012.

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O1C2-2-5 Development of a new mice model of asthma using the epochal reagent IMMUCRAFT

Maho Noguchi1, Kazuhiko Shinagawa1, Miyuki Takashima1, Hiroyuki Takamatsu1, Kazuo Umemura2
1Hamamatsu Pharma Research, Inc., 2Dept. Pharmacol., Hamamatsu, Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 81-81, 2012.

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O1C2-3-1 EGFR tyrosine kinase inhibition leads to suppression of cancer cell migration independent of anti-proliferative effect

Eun-Ji Lee1, Toru Kimura1, Yasunao Kogashiwa1, 2, Hiroyuki Sakurai1
1Dept. Pharmacol., Kyorin Univ. Sch. Med., 2Dept. Otolaryngo., Kyorin Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 81-81, 2012.

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O1C2-3-2 Pharmacogenomics of Tumor Angiogenesis in Novel Human Cancer XenoTransplantation Model

Junya Kuroyanagi1, Noriko Umemoto1, Beibei Zhang1, Yasuhito Shimada1, 2, 3, 4, Yuhei Nishimura1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Mol. and Cell. Pharmacol., Pharmacogenomics and Pharmacoinformatics, Mie Univ. Grad. Sch. of Med, 2Dept. Bioinfo., Mie Univ Life Sci. Res. Cent., 3Mie Univ. Med. Zf. Res. cent., 4Dept. of Omics Med., Mie Univ. Industrial Technology Innovation Institute
Journal of Pharmacological Sciences 118 (suppl) 81-81, 2012.

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O1C2-3-3 Defective NF-кB signaling in metastatic head and neck cancer cells leads to enhanced apoptosis by dsRNA

Naoki Umemura1, Saumendra Sakar2, Hiroshi Sakagami1
1Divi of Pharma. Dept. of Diagnostic. Therap., Meikai Univ. Sch. Dent., 2Cancer Virology. Cancer Institute. Univ of Pittsburgh
Journal of Pharmacological Sciences 118 (suppl) 81-81, 2012.

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O1C2-3-4 Metformin-induced lactic acidosis in Mate1 knockout mice

Atushi Yonezawa, Kana Toyama, Toshiya Katsura
Dept. Pharmacy Kyoto Univ. Hosp.
Journal of Pharmacological Sciences 118 (suppl) 82-82, 2012.

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O1C2-3-5 Population pharmacokinetic modeling of repaglinide in healthy Malaysian volunteers with application of the NPAG algorithm

A. B. Ruzilawati1, A. W. Mohd Suhaimi1, A. Imran2, S. H. Gan3
1Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 2Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, 3Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia
Journal of Pharmacological Sciences 118 (suppl) 82-82, 2012.

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O1C2-4-1 Angiotensin II causes impaired IRS-1/eNOS pathway via PTP1B activation in aorta from type 2 diabetic rats

Shingo Nemoto, Kumiko Taguchi, Takayuki Matsumoto, Katsuo Kamata, Tsuneo Kobayashi
Dept. Physiol, and Morphol., Inst Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 118 (suppl) 82-82, 2012.

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O1C2-4-2 Enhanced prostaglandine E2-induced contraction in superior mesenteric arteries from type 2 diabetic rats is due to altered EP3 receptor-PKCδ pathway

Keiko Ishida, Takayuki Matsumoto, Kumiko Taguchi, Katsuo Kamata, Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 118 (suppl) 82-82, 2012.

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O1C2-4-3 Internalization of the plasma membrane 5-hydroxytryptamine2A (5-HT2A) receptor Induced by insulin in the isolated human endothelium-denuded saphenous vein

Tasuku Kanai1, Masachika Kuwabara2, Naoko Totoribe1, Yasuko Matsuo1, Eisaku Nakamura3, Shuji Gamoh1, Akito Suzuki4, Yujiro Asada5, Hiroaki Hisa6, Ryuichi Yamamoto1
1First Dept. Pharmacol., Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare, 2Kuwabara Clinic, 3Dept. Cardiovasc. Surg. Miyazaki Pref., 4Dept. Clinical Pharmaceutical, Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare, 5Dept. Pathol., Faculty of Med., Miyazaki Univ., 6Second Dept. Pharmacol., Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfale
Journal of Pharmacological Sciences 118 (suppl) 83-83, 2012.

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O1C2-4-4 Enhancement of Endothelin-1-induced myofilament sensitization to Ca2+ and its mechanisms after subarachnoid hemorrhage (SAH)

Yuichiro Kikkawa1, 2, Satoshi Matsuo1, Mayumi Hirano2, Akira Nakamizo1, Tomio Sasaki1, Katsuya Hirano2
1Dept. Neurosurg., Grad Sch Med Sci., Kyushu Univ., 2Div. Mol. Cardiol., Res. Inst. Angiocardiol., Grad Sch Med Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 83-83, 2012.

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O1C2-5-1 Roles of Ca2+ release-activated Ca2+ (CRAC) channels on cell proliferation in bovine brain capillary endothelial cells

Hiroaki Kito1, Daiju Yamazaki1, 2, 3, Susumu Ohya1, Hisao Yamamura1, Kiyofumi Asai3, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci, Nagoya City Univ., 2Dept. Biol. Chem., Grad. Sch. Pharmceut. Sci, Kyoto Univ., 3Dept. Mol. Neurobiol., Grad. Sch. Med. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 118 (suppl) 83-83, 2012.

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O1C2-5-2 Mechanism underlying statin-induced up-regulation of CD39 in endothelial cells

Isao Matsuoka, Masa-aki Ito
Lab. Pharmacol. Facul. Pharm. Takasaki Univ. Health and Welfare
Journal of Pharmacological Sciences 118 (suppl) 83-83, 2012.

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O1C2-5-3 SDF-1α inhibits vascular endothelial permeability

Kanako Sato, Koji Kobayashi, Takahisa Murata, Masatoshi Hori, Hiroshi Ozaki
Department of Veterinary Pharmacology, The University of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 84-84, 2012.

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O1C2-5-4 Possible role of gap junction agonist-induced endothelium-dependent hypotension in anesthetized rats

Shuhei Kobuchi, Kazuhide Ayajiki
Dept. Pharm., School of Pharm., Hyogo Univ. Health Sci.
Journal of Pharmacological Sciences 118 (suppl) 84-84, 2012.

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O2B1-1-1 Changes in contribution of inward rectifying K+ channel (Kir2.1) to vascular smooth muscle tone in small artery of renovascular hypertensive model mice

Fumito Maruyama1, William C. Cole2, Hideaki Ishii1, Hisao Yamamura1, Susumu Ohya1, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Smooth Muscle Research Group, Fac. Med., Univ. Calgary
Journal of Pharmacological Sciences 118 (suppl) 84-84, 2012.

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O2B1-1-2 Hypertension related alterations in α1-adrenergic responsiveness of the rat seminal vesicle and vas deferens

Makoto Yono1, 2, Takanori Tanaka1, Shigeki Tsuji1, Shin Irie1, Yukikuni Sakata1, Masayuki Otani2, Jamshid Latifpour3
1Dept. Clin. Pharmacol., Nishi-Kumamoto Hosp., Med. Co.LTA, 2Dept. Urol., Nishi-Kumamoto Hosp., Med. Co.LTA, 3Sect. Urol., Yale Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 84-84, 2012.

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O2B1-1-3 The likelihood that non-RAAS cause hypertension.

Kana Ooshima, Masaki Tabuchi, Atsuko Niwa, Kyoko Nakamura, Hideo Takahashi
Dept. Pharmacol. Kinki Univ. Facul. Med.
Journal of Pharmacological Sciences 118 (suppl) 85-85, 2012.

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O2B1-1-4 Effects of adiponectin on spontaneous stroke in rats.

Masaki Tabuchi1, Kana Ooshima1, Hiroshi Sakaue2, Kyoko Nakamura1, Atsuko Niwa1, Hideo Takahashi1
1Dept. Pharmacol. Kinki Univ. Facul. Med., 2Dept. Nutr. Metab. Inst. Health Biosci, Grad. Sch. Univ. Tokushima
Journal of Pharmacological Sciences 118 (suppl) 85-85, 2012.

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O2B1-1-5 Long-term voluntary exercise improves the efficacy of cerebral angiogenesis and neurogenesis in stroke-prone genetically hypertensive rats

Atsuko Niwa1, Yasumitsu Akahoshi2, Shinji Kurashimo2, Hideo Takahashi1
1Dept. Pharmacol., Kinki Univ. Facul. Med., 2Kinki Univ. Life Sci. Res. Inst.
Journal of Pharmacological Sciences 118 (suppl) 85-85, 2012.

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O2B1-2-1 Possible involvement of heat shock factor-1 in the impairment of the HSP72 induction of the failing heart following myocardial infarction in rats

Tetsuro Marunouchi, Mao Murata, Masato Araki, Norio Takagi, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.
Journal of Pharmacological Sciences 118 (suppl) 85-85, 2012.

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O2B1-2-2 Interleukin-11 Exhibits the Post-conditioning Effects against Ischemia Reperfusion injury via Cardiac Signal Transducer and Activator of Transcription 3

Kaori Miyamoto1, Masanori Obana1, Makiko Maeda2, Hiroyuki Nakayama1, Yasushi Fujio1
1Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ., 2Dept. Clin. Phrmacogenom. Hyogo Univ of Health Sci. Pharma.
Journal of Pharmacological Sciences 118 (suppl) 86-86, 2012.

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O2B1-2-3 Preoperative stabilization of HIF-1 by systemic introduction of dimethyloxalylglycine (DMOG), improves skin flap survival

Shuhei Tomita1, Mitsuru Takaku2, Noriko Yamano1, Yuki Ishizawa1, Yoshitaka Kihira1, Keisuke Ishizawa3, Yasumasa Ikeda1, Koichiro Tsuchiya3, Toshiaki Tamaki1
1Dept. Pharmacol., Inst. Healthbiosci. Tokushima Univ., 2Dept. Plast. Surg., Inst. Healthbiosci. Tokushima Univ., 3Dept. Med. Pharmacol., Inst. Healthbiosci. Tokushima Univ.
Journal of Pharmacological Sciences 118 (suppl) 86-86, 2012.

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O2B1-2-4 Role of NO and Kv Channels in the Acidic pH-Induced Vasorelaxation in Rat Aorta

Tomoya Sasahara, Katsutoshi Yayama, Hiroshi Okamoto
Dept. Cardiovascular Pharmacol., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 86-86, 2012.

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O2B1-3-1 Apoptosis is likely induced by an increase in cytosolic Ca2+ in rat cardiomyocytes through mitochondrial cGMP-protein kinase pathway

Ken-Ichi Furukawa1, Kazuhiko Seya1, Kyoichi Ono2, Susumu Fujisawa2, Ken Okumura3, Shigeru Motomura1
1Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med., 2Dept. Cell Physiol., Akita Univ. Grad. Sch. Med., 3Dept. Cardiol. Respir. Med. Nephrol., Hirosaki Univ. Grad, Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 86-86, 2012.

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O2B1-3-2 The role of sigma-1 receptor for SR-mitochondrial calcium signaling in cardiomyocytes.

Hideaki Tagashira, Norifumi Shioda, Kohji Fukunaga
Dept. Pharmacol. Tohoku Univ. Grad. Sch. Pharm. Scis.
Journal of Pharmacological Sciences 118 (suppl) 87-87, 2012.

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O2B1-3-3 Evaluation of autophagic activity in the heart of Tsumura Suzuki Obese Diabetes mice and db/db mice

Shigeo Miyata1, Miyuki Yagi1, Mikio Nakazawa2, Tomie Kawada1
1Res. Inst. Pharmaceutical Sci., Musashino Univ., 2Dept. Med. Tech., Sch. Health Sci., Fac. Med., Niigata Univ.
Journal of Pharmacological Sciences 118 (suppl) 87-87, 2012.

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O2B1-3-4 L-Citrulline ameliorates dysfunction of retinal circulation in diabetic rats

Toshiaki Takei1, Asami Mori1, Masahiko Morita2, Satoshi Nakagawa2, Kenji Sakamoto1, Tutomu Nakahara1, Kunio Ishii1
1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Healthcare products development center, KYOWA HAKKO BIO CO.,LTD.
Journal of Pharmacological Sciences 118 (suppl) 87-87, 2012.

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O2B1-3-5 Automated high content image analysis for anticancer drug-induced cardiotoxicity in zebrafish

Noriko Umemoto1, Saki Ito1, Kana Okamori1, Yuhei Nishimura1, 2, 3, 4, Miko Kawabata1, 5, Junya Kuroyanagi1, Yasuhito Shimada1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Mol. and Cell. Pharmacol., Pharmacogeno. and Pharmacoinfor., Mie Univ. Grad. Sch. Med, 2Mie Univ. Med. Zebra. Res. Cent., 3Dept. Bioinfo. Mie Univ. Life Sci. Res. Cent., 4Dept. Omics Med., Mie Univ. Indu. Tech. Innov. Inst., 5Dept. Clin. Anesthe. Mie Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 87-87, 2012.

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O2B1-4-1 Increased susceptibility to ventricular arrhythmias in heart/muscle-specific manganese-superoxide dismutase-deficient mice： beneficial effects of apple polyphenols

Akio Matsumoto1, Tadahiro Sunagawa2, Takahiko Shimizu3, Yusuke Ozawa3, Hiroo Maruyama1, Motoyuki Tagashira2, Tomomasa Kanda2, Takuji Shirasawa4, Haruaki Nakaya1
1Dept. Pharmacol. Chiba Univ. Grad. Sch. Med., 2Asahi Breweries, 3Mol. Gerontol. Tokyo Metro. Inst. Gerontol., 4Dept. Aging Cont. Med. Juntendo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 88-88, 2012.

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O2B1-4-2 In vivo electropharmacological effects of oseltamivir

Ken Kitahara1, 2, Yuuji Nakamura1, Yayoi Tuneoka3, Sanae Suzuki4, Satomi Adachi-Akahane1, Hikaru Tanaka3, Akira Takahara4, Junichi Yamazaki2, Atsusi Sugiyama1
1Dept. of Pharmacol., Faculty of Med., Toho Univ., 2Dept. Cardiovasc. Med., Toho Univ. Omori Medical Center, 3Dept. of Pharmacol., Faculty of Pharm. Sci., Toho Univ., 4Dept. of Pharmacol. Ther., Faculty of Pharm. Sci., Toho Univ.
Journal of Pharmacological Sciences 118 (suppl) 88-88, 2012.

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O2B1-4-3 Oseltamivir lacks torsadogenic potential

Yuji Nakamura1, Ken Kitahara1, Rieko Sasaki2, Satomi Adachi-Akahane1, Hikaru Tanaka2, Akira Takahara2, 3, Atsushi Sugiyama1
1Dept. Pharmacol., Faculty of Med., Toho Univ., 2Dept. Pharmacol., Faculty of Pharm. Sci., Toho Univ., 3Dept. of Pharmacol. Ther., Faculty of Pharm. Sci., Toho Univ.
Journal of Pharmacological Sciences 118 (suppl) 88-88, 2012.

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O2B1-4-4 Multistep electrical remodeling in inherited DCM heart

Takeshi Suzuki1, 2, Takao Shioya3, Takashi Murayama1, Masami Sugihara1, 2, Fuminori Odagiri1, 2, Yuji Nakazato2, Hiroyuki Daida2, Takashi Sakurai1, Sachio Morimoto4, Nagomi Kurebayashi1
1Dept Pharmacol., Juntendo Univ. Sch. Med., 2Dept Cardiol. Juntendo Univ. Sch. Med, 3Dept. Physiol., Fac. Med. Saga Univ., 4Dept Clin Pharmacol., Fac. Med. Kyushu Univ
Journal of Pharmacological Sciences 118 (suppl) 88-88, 2012.

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O2B1-4-5 Chronic activation of β2-adrenergic and M2-muscarinic receptors decreases the t-tubular L-type Ca2+ channel activity in failing ventricular myocytes

Toshihide Kashihara1, Tsutomu Nakada1, Toshihide Shibazaki1, Xiaona Sheng2, Shimmon Gomi1, Mitsuhiko Yamada1
1Dept. Mol. Pharmacol., Shinshu Univ. Sch. Med., 2Dept. Met. Reg., Inst. on Aging and Adapt., Shinshu Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 89-89, 2012.

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O2B1-5-1 KCNE1 is essential for inhibition of KCNQ1/KCNE1 currents by insulin

Minghua Wu, Ikuo Norota, Kazuya Kurakami, Kuniaki Ishii
Dept. Phamacol., Yamagata Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 89-89, 2012.

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O2B1-5-2 Mechanism and physiological role of short term desensitization of muscarinic K+ current in the heart

Shingo Murakami, Yoshihisa Kurachi
Dept. Pharmacol., Osaka Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 89-89, 2012.

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O2B1-5-3 Mutation of TNNI3K C-terminal regulatory region increased incidence of arrhythmias in cultured cardiomyocytes and in vivo mouse hearts

Zhong-Fang Lai1, Yu-Zhen Chen2, Hirohisa Tsuda1, Shokei Kim-Mitsuyama1
1Dept. Pharmacol. Mol. Therap., Grad. Sch. Med. Sci., Kumamoto Univ., 2Dept. Immunogene., Grad. Sch. Med. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 89-89, 2012.

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O2B1-5-4 Effect of α-adrenoceptor-stimulation on the excitation-contraction mechanisms in neonatal and adult mouse ventricular myocardium

Shogo Hamaguchi, Yoriko Honda, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 90-90, 2012.

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O2B2-1-1 Role of Kca3.1 K+ channel in T-lymphocyte function of delayed-type hypersensitivity model mice

Susumu Ohya, Sayuri Horiba, Erina Nakamura, Miki Matsui, Hisao Yamamura, Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 118 (suppl) 90-90, 2012.

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O2B2-1-2 The disturbance of glycolysis induced by hydrogen peroxide and high glucose in human monocytic U937 cells

Yasunori Takeda1, Yuya Nakamura1, 2, Masahiro Inagaki1, Mayumi Tsuji1, Hitomi Hasegawa1, Masanobu Watanabe1, Hiromichi Gotoh2, Yoshikazu Goto2, Katsuji Oguchi1
1Dept. Pharmacol., Showa Univ. Sch. Med., 2Saiyu Soka Hosp.
Journal of Pharmacological Sciences 118 (suppl) 90-90, 2012.

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O2B2-1-3 Histamine-mediated granule maturation of murine mast cells

Satoshi Tanaka
Grad. Sch. Med. Dent. & Pharmaceutic. Sci., Okayama Univ.
Journal of Pharmacological Sciences 118 (suppl) 90-90, 2012.

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O2B2-1-4 Adrenoceptor-mediated enhancement of IL-33 production by dendritic cells

Yoshiki Yanagawa, Machiko Matsumoto, Hiroko Togashi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
Journal of Pharmacological Sciences 118 (suppl) 91-91, 2012.

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O2B2-1-5 COX-2 - dependent prevention of secondary lymphedema through the enhancement of lymphangiogenesis

Shinya Kashiwagi1, 2
1Dept. Pharmacol., Kitasato Univ. Sch. Med, 2Dept. Plast Surg., Kitasato Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 91-91, 2012.

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O2B2-2-1 Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arteriat smooth muscle cells

Hisao Yamamura1, Aya Yamamura1, Eun A. Ko1, Nicole M. Pohl1, Amy Zeifman1, Patricia A. Thistlethwaite2, Jason X.-J. Yuan1
1Dept. Med., Univ. Illinois at Chicago, 2Dept. Med., Univ. California
Journal of Pharmacological Sciences 118 (suppl) 91-91, 2012.

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O2B2-2-2 Expression of TMEM16 family and Ca2+ activated Cl- channel activity in smooth muscle cells

Junya Ohshiro, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci, Nagoya City Univ
Journal of Pharmacological Sciences 118 (suppl) 91-91, 2012.

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O2B2-2-3 Caveola regulates vascular smooth muscle cell function via BK-Cav1.2 complex.

Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept. Mol. & Cell. Pharmcol., Grad. Sch. Pharmceu. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 118 (suppl) 92-92, 2012.

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O2B2-2-4 Biphasic change of thioredoxin interacting protein (TxnIP) gene expression after an S-nitrosoglutathione (GSNO) treatment in mouse vascular smooth muscle cells.

Hidemi Endo, Akio Matsumoto, Tomoko Tachibana, Haruaki Nakaya
Dept. Pharmacol., Grad. Sch. Med., Chiba Univ.
Journal of Pharmacological Sciences 118 (suppl) 92-92, 2012.

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O2B2-3-1 Nitrosonifedipine prevents the progression of diabetic nephropathy in type II diabetic mice

Shoko Fujii1, Keisuke Ishizawa1, Takumi Sakurada2, Yuki Izawa-Ishizawa2, Masaki Imanishi2, Asami Nuno1, Yuta Suzuki1, Yoshitaka Kihira2, Yasumasa Ikeda2, Shuhei Tomita2, Koichiro Tsuchiya1, Toshiaki Tamaki2
1Dept. Med. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch., 2Dept. Pharmacol., Inst. HBS, Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 92-92, 2012.

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O2B2-3-2 Mechanisms for development of diabetic nephropathy -Degradation of advanced glycation end-product -aggregated protein in mesangial cells of glomeruli-

Tadashi Nagamatsu1, 2, Takahiro Toda1, Shinya Yamamura1, Takuya Morishita1, Yasushi Hirasawa1, 2
1Dept. Pharmacobiol. Therap., Meijo Univ. Sch. Pharm., 2Nihon Bioresearch Inc.
Journal of Pharmacological Sciences 118 (suppl) 92-92, 2012.

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O2B2-3-3 Aldosterone induces apoptosis of proximal tubular cells through p21/TNF-α-dependent pathway

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O2B2-3-4 Glomerular mineralocorticoid receptor activation limits the benefits of salt reduction in Dahl salt-sensitive rats

Daisuke Nakano, Kento Kitada, Ya Liu, Yoshihide Fujisawa, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama
Dept. Pharmacol., Kagawa Univ.
Journal of Pharmacological Sciences 118 (suppl) 93-93, 2012.

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O2B2-3-5 Down-regulation of the large-conductance Ca2+-activated K+ channel, KCa1.1 in the prostatic stromal cells of benign prostate hyperplasia

Satomi Niwa1, Susumu Ohya1, Yoshiyuki Kojima2, Shoichi Sasaki2, Hisao Yamamura1, Motomu Sakuragi3, Kenjiro Kohri2, Yuji imaizumi1
1Dept. Mol. & Cell Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Dept. Nephro-uro., Grad. Sch. Med. Sci., Grad. Nagoya City Univ., 3Hanno Research Center, Taiho Pharmaceutical Co.
Journal of Pharmacological Sciences 118 (suppl) 93-93, 2012.

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O2B2-4-1 Chronic measurement of renal sympathetic nerve activity (RSNA) in rats by using a telemetry system

Naoki Kondo1, Yoshihide Fujisawa2, Masako Fujita1, Hiroko Nogami1, Kazuyo Kawakami1, Masahiro Moritoki1, Satoru Nishioka1, Yoko Nishijima1, Tadashi Sofue1, Kumiko Kaifu1, Taiga Hara1, Kento Kitada1, Daisuke Nakano3, Masakazu Kono1, Akira Nishiyama3
1Dept. Cardiorenal & Cerebrovasc., Kagawa Univ., 2Medicine Life Sci. Res. Center, Kagawa Univ., 3Dept. Pharmacol., Kagawa Univ.
Journal of Pharmacological Sciences 118 (suppl) 93-93, 2012.

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O2B2-4-2 Visualization of spatiotemporal activity of the spinal motor neurons in zebrafish with a genetically-encoded calcium indicator

Masamichi Ohkura1, Akira Muto2, Tomoya Kotani2, Shin-ichi Higashijima3, Koichi Kawakami2, Junichi Nakai1
1Saitama Univ. Brain Sci. Inst., 2Dept. Genet., Natl. Inst. Genet., 3Okazaki Inst. Integrative Biosci.
Journal of Pharmacological Sciences 118 (suppl) 94-94, 2012.

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O2B2-4-3 Investegated freezing methods from water dyanamics by Aquaporin

Yasuhiro Kato1, 2, Manami Tanaka1, Youichiro Abe1, Masato Yasui1
1Dept. Pharmacol., Keio Univ. Sch. Med., 2OSC, TDC
Journal of Pharmacological Sciences 118 (suppl) 94-94, 2012.

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O2B2-4-4 Development of fluorometric analysis for characterization of organic anion transporters

Makiko Nakamura1, Shinsuke Arakawa1, Koudai Matsuo1, Naohiko Anzai2, Makoto Hosoyamada3, Kimiyoshi Ichida1
1Dept. Pathophysiol., Tokyo Univ. Pharm. Life Sci., 2Dept. Pharmacol., Dokkyo Med. Univ., 3Dept. Physiol. Chem., Teikyo Univ.
Journal of Pharmacological Sciences 118 (suppl) 94-94, 2012.

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O2B2-4-5 Cell surface expression and functional assay of signal peptide-attached HaloTag-GPCR

Yuka Sudo1, 3, Minoru Hojo2, Kanako Miyano3, Masami Suzuki3, Kiyoshi Terawaki3, Seiji Shiraishi3, Noriyuki Nishida1, Yasuhito Uezono3
1Dept. Mol. Cell. Biol., Nagasaki Univ. Grad Sch. Med. Sci, 2Dept. Anesthesiology, Nagasaki Univ. Grad Sch. Med. Sci, 3Dept. Cancer Pathophysiol., NCCRI
Journal of Pharmacological Sciences 118 (suppl) 94-94, 2012.

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O2B2-4-6 Development of recombinant cell line dying upon single action potential occurrence for the assay of compounds acting on voltage-dependent K+ (Kv) channels

Masato Fujii, Susumu Ohya, Hisao Yamamura, Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ
Journal of Pharmacological Sciences 118 (suppl) 95-95, 2012.

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O2B2-5-1 Mechanism of pruritus induced by successive application of glucocorticoid to mouse skin.

Ryosuke Doi, Katsunori Yamaura, Eriko Suwa, Koichi Ueno
Dept. Geriatr. Pharmacol. Therapeut., Grad. Sch. Pharmaceut. Sci., Chiba Univ.
Journal of Pharmacological Sciences 118 (suppl) 95-95, 2012.

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O2B2-5-2 The effects of celecoxib on chemotherapy-related fatigue in mice

Naoki Matsukawa, Kouichi Yamamoto, Asuka Goto, Atsushi Yamatodani
Department of Medical Science and Technology, Division of Health Sciences, Graduate School of Medicine, Osaka University
Journal of Pharmacological Sciences 118 (suppl) 95-95, 2012.

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O2B2-5-3 2, 4, 6-Trinitrobenzene sulfonic acid (TNBS)-induced colitis Disturbs the Sleep-Wake Pattern ： Analysis Using Radiotelemetry System in Conscious Rats

Naruomi Yamada1, 2, Masayuki Uchida1, Masayuki Suzuki2, Kimiko Shimizu1, Orie Mogami1
1Food Science Research Labs., R&D Div., Meiji Co.Ltd., 2Research & Development Labs., R&D Div., Meiji Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 95-95, 2012.

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O2B2-5-4 siRNA targeting apelin prevents the increase in capillary density and abnormal vessels in retina induced by hypoxia

Yuki Ishimaru1, Atsushi Kasai1, 2, Kosuke Higashino1, Yasuhiro Yoshioka1, Akiko Yamamuro1, Sadaaki Maeda1
1Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., 2Dept. Psychiatry, Semel Institute for Neuroscience and Human Behavior, UCLA
Journal of Pharmacological Sciences 118 (suppl) 96-96, 2012.

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O2B2-5-5 Involvement of calpain in dysfunction of gap junction in the cochlear spiral ligament following oxidative stress

Reiko Nagashima, Taro Yamaguchi, Kiyokazu Ogita
Dept. Pharmacol. Univ. of Setsunan
Journal of Pharmacological Sciences 118 (suppl) 96-96, 2012.

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O2C1-1-1 IRF family transcription factor axis governs gene expression program in microglia that drives neuropathic pain

Takahiro Masuda1, Makoto Tsuda1, Ryohei Yoshinaga1, Nao Nishimoto1, Shosuke Iwamoto1, Tomohiko Tamura2, Kazuhide Inoue1
1Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2Dept. Immunol., Grad. Sch. Med., Yokohama City Univ.
Journal of Pharmacological Sciences 118 (suppl) 96-96, 2012.

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O2C1-1-2 Interferon regulatory factor-5 in spinal microglia is a crucial transcription factor for the development of neuropathic pain

Ryohei Yoshinaga1, Makoto Tsuda1, Takahiro Masuda1, Nao Nishimoto1, Hidetoshi Tozaki-Saitoh1, Tomohiko Tamura2, Kazuhide Inoue1
1Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ., 2Dept. Immunol., Grad. Sch. Med., Yokohama City Univ.
Journal of Pharmacological Sciences 118 (suppl) 96-96, 2012.

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O2C1-1-3 The role of spinal CB2 receptors in the treatment of neuropathic pain

Hiroshi Shimoyama, Takahiro Masuda, Ryohei Yoshinaga, Nao Nishimoto, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 97-97, 2012.

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O2C1-1-4 Epigenetic therapy targeting histone deacetylase in chronic pain

Kohei Araki, Hiroshi Ueda
Div. Mol. Pharmacol. & Neurosci. Nagasaki Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 97-97, 2012.

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O2C1-1-5 Donepezil causes permanent pain relief in mouse experimental fibromyalgia model

Takehiro Mukae, Hiroshi Ueda
Div. Mol. Pharmacol. & Neurosci. Nagasaki Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 97-97, 2012.

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O2C1-2-1 Molecular cloning and functional characterization of amphibian TRPV1 reveals its functional evolution for polymodal stimuli.

Masashi Ohkita1, Shigeru Saito2, Kenji Takahashi1, Makoto Tominaga2, Toshio Ohta1
1Dept. Vet. Phamacol., Fac. Agri., Tottori Univ., 2Div. Cell Signaling. NIPS
Journal of Pharmacological Sciences 118 (suppl) 97-97, 2012.

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O2C1-2-2 Decrease of oral morphine analgesia via increase of intestinal P-glycoprotein levels by repeated oral etoposide

Takuro Kobori1, Ayaka Nawa1, Mana Kobayashi1, Kazuma Matsumoto1, Shinichi Harada1, Kazuo Nakamoto1, Wakako Fujita-Hamabe1, Shiroh Kishioka2, Shogo Tokuyama1
1Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ., 2Dept. Pharmacol., Wakayama Med Univ.
Journal of Pharmacological Sciences 118 (suppl) 98-98, 2012.

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O2C1-2-3 PRIP1 and PRIP double knock out mice exhibit a different phenotype in the pain signaling

Tomoya Kitayama, Katsuya Morita, Takashi Kanematsu
Dept. Dent. Pharmacol., Hiroshima Univ., Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 98-98, 2012.

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O2C1-2-4 Stress affects the colorectal distension-induced noradrenaline release in the bed nucleus of the stria terminalis

Soichiro Ide1, Ryuta Yamamoto1, Hiroshi Takeda2, Masabumi Minami1
1Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ., 2Lab. Pathophysiol. Therapeut., Grad. Sch. Pharm. Sci., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 98-98, 2012.

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O2C1-2-5 Regulation of insulin-like growth factor-1 receptor expression by Hsp90 and co-chaperones

Toshihiko yanagita, Takayuki Nemoto, Norie Yoshikawa, Shinya Satoh, Toyoaki Maruta, Manabu Murakami
Dept. Pharmacol., Miyazaki Univ.
Journal of Pharmacological Sciences 118 (suppl) 98-98, 2012.

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O2C1-3-1 MAGE-D1 knockout mice express depressive endophenotypes associated with downrgulation of serotonin transporter ubiquitylation

Akihiro Mouri1, 2, 3, Aya Sasaki4, 5, Ken Watanabe5, Chiharu Sogawa6, Shigeo Kitayama6, Takayoshi Mamiya1, Yoshiaki Miyamoto7
1Dept. Chem Pharm., Meijo. Univ. Grad. Sch. Pharm., 2Dept. Neuropsychopharm. and Hosp. Pharm., Nagoya Univ., Grad. Sch., Med., 3Div. Clin. Sci. and Neuropsychopharm, Meijo. Univ. Grad. Sch., Pharm Sci., 4Dept. Pathol., Sch. Med., Keio Univ, 5Dept. Bone Joint Dis., Nat. Cent. Geria. Geron., 6Dept. Dent. Pharm., Okayama Univ. Grad. Sch., Med. Dent. and Pharm. Sci., 7Dept. Pharma. Ther. and Neuropharm., Pharm. Sciences, Grad. Sch. of Med. and Pharm. Sci., Univ of Toyama.
Journal of Pharmacological Sciences 118 (suppl) 99-99, 2012.

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O2C1-3-2 Characterization of trace elements levels and histamine receptors in mice brains

Eiko Sakurai1, Keizo Ishii2, Takahiro Sato3, Tomihiro Kamiya3, Kazuhiko Yanai4
1Faculty of Pharmacy, Iwaki Meisei Univ., 2Science and Energy Enginee., Tohoku Univ., 3JAEA-Takasaki, 4Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 99-99, 2012.

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O2C1-3-3 Noradrenergic transmission within the bed nucleus of the stria terminalis regulates food intake and anxiety-like behaviors.

Kana Koseki1, 2, Tomonori Naka1, Tomokazu Nakako1, Mikie Hirata1, Soichiro Ide1, Mitsuhiro Yoshioka2, Masabumi Minami1
1Dept. Pharmacol. Grad Sch Pharm Sci. Hokkaido Univ., 2Dept Neuropharmacol. Grad Sch Med. Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 99-99, 2012.

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O2C1-3-4 Milnacipran Enhances Inhibitory Control of Impulsive Action through Stimulating D1-like receptors in the Infralimbic Cortex

Iku Kimura1, Yu Ohmura1, Takeshi Izumi1, Haruko Kumamoto1, Taku Yamaguchi2, Takayuki Yoshida1, Mitsuhiro Yoshioka1
1Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med., 2Dept. Pharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.
Journal of Pharmacological Sciences 118 (suppl) 99-99, 2012.

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O2C1-3-5 Analysis of molecular mechanism underlying the upregulated SERT function in RN46A cells by the long-term treatment with cAMP analogue.

Hikaru Yamamoto, Shigeru Tanaka, Takahiro Seki, Izumi Hide, Norio Sakai
Dept. Pharmacol. Neurosci., Grad. Sch. Biomed. Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 100-100, 2012.

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O2C1-4-1 Upregulation of Runx2 expression by ATP in microglial cells

Ryota Nakazato, Takeshi Takarada, Yukio Yoneda
Laboratory of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology
Journal of Pharmacological Sciences 118 (suppl) 100-100, 2012.

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O2C1-4-2 Functional analysis of clock genes expressed in microglia

Shogo Hotta1, Takeshi Takarada1, Shigeki Shimba2, Yukio Yoneda1
1Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci., 2Research unit of Health Sci., Sch. of Pharm. Nihon Univ.
Journal of Pharmacological Sciences 118 (suppl) 100-100, 2012.

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O2C1-4-3 Microglial Ca2+-activated K+ channels are possible molecular targets for the Analgesic Effects of S-ketamine

Yoshinori Hayashi, Kodai Kawaji, Hiroshi Nakanishi
Dept. Aging Sci. and Pharmacol., Fac. Dent. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 100-100, 2012.

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O2C1-4-4 Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain

Zhou Wu, Li Sun, Yoshinori Hayashi, Hirosi Nakanishi
Dept. Aging Sci. and Pharmacol., Fac. Dent. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 101-101, 2012.

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O2C1-4-5 Zinc-induced microglial activation depends on transporter-mediated zinc uptake and sequential activation of P2X7 receptors

Takaaki Matsuo, Shohei Segawa, Kentaro Nishida, Youichirou Higashi, Kazuki Nagasawa
Dept. Environ. Biochem., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 101-101, 2012.

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O2C1-5-1 Role of P2X7 receptors in regulation of P2X4 receptors expression on the plasma membrane of microglia

Tomohiro Yamashita, Makoto Tsuda, Hidetoshi Saitoh, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 101-101, 2012.

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O2C1-5-2 Signaling mechanisms regulating alternative activation of BV-2 microglia

Yukiko Komichi, Akinori Hisatsune, Yoichiro Isohama, Hiroshi Katsuki
Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci. Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 101-101, 2012.

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O2C1-5-3 Role of extracellular RNA in neural injury-evoked astrocytic chemokine production

Hikaru Igarashi, Yuuki Yamashita, Hiroki Tanaka, Tatsuya Kibayashi, Takahiro Katayama, Masabumi Minami
Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 102-102, 2012.

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O2C1-5-4 Prostaglandin I2 promotes migration of oligodendrocyte precursor cells and is involved in recovery of motor function in a lysolecithin-induced demyelination mouse model.

Chisato Takahashi1, 2, Rieko Muramatsu1, 2, Toshihide Yamashita1, 2
1Dep. Mol. Neurosci., Osaka Univ. Grad. Sch. Med., 2JST-CREST
Journal of Pharmacological Sciences 118 (suppl) 102-102, 2012.

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O2C1-5-5 Inositol 1, 4, 5-trisphosphate signaling maintains the activity of glutamate uptake in Bergmann glia

Yohei Okubo1, Masato Mashimo1, 3, Toshiko Yamazawa1, Miwako Yamasaki2, Masahiko Watanabe2, Toshihiko Murayama3, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., Univ., 2Dept. Anatomy, Hokkaido Univ. Sch. Med., 3Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Chiba Univ.
Journal of Pharmacological Sciences 118 (suppl) 102-102, 2012.

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O2C2-1-1 Dysfunction of the neuronal differentiation on tunicamycin-induced endoplasmic reticulum stress

Shunsaku Touno1, Koichi Kawada1, Naoki Fujinaga1, Masayuki Kaneko1, Yasuyuki Nomura2, Yasunobu Okuma1
1Dept. Pharmacol., Chiba Inst. Sci., 2Lab. Pharmacotherapeutics, Yokohama Col. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 102-102, 2012.

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O2C2-1-2 Suppression of differentiation by solute carrier OCTN1/SLC22A4 in murine neuroblastoma Neuro2a cells

Noritaka Nakamichi, Hiroshi Hosotani, Takayuki Taguchi, Tomoko Sugiura, Yukio Kato
Fac. Pharm., Kanazawa Univ.
Journal of Pharmacological Sciences 118 (suppl) 103-103, 2012.

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O2C2-1-3 Involvement of hypothalamic orexin system in the nicotine-induced modulation of hepatic glucose production in mice

Hiroshi Tsuneki, Mikio Fujita, Emi Tokai, Kaoru Yamaguchi, Tsutomu Wada, Toshiyasu Sasaoka
Dept. Clin. Pharmacol., Univ. of Toyama
Journal of Pharmacological Sciences 118 (suppl) 103-103, 2012.

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O2C2-1-4 Excitatory effects of CCK on GLP-1 releasing neurons are mediated via adrenergic neurons

Kazunari hisadome, Noriyoshi Teramoto
Dept. Pharmacol., Saga Univ. Sch Med.
Journal of Pharmacological Sciences 118 (suppl) 103-103, 2012.

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O2C2-1-5 A study of glutathione synthesis in GTRAP3-18-deficient mice

Koji Aoyama1, Fan Wang1, Nobuko Matsumura1, Hiroshi Kiyonari2, Go Shioi2, Karo Tanaka1, Chisato Kinoshita1, Kazue Utsumi1, Masahiko Watabe1, Toshio Nakaki1
1Dept. Pharmacol., Teikyo Univ. Sch. Med., 2RIKEN, CDB, LARGE
Journal of Pharmacological Sciences 118 (suppl) 103-103, 2012.

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O2C2-2-1 Nitric oxide-induced Ca2+ release (NICR) mediated by ryanodine receptor 1 is essential for synaptic plasticity in the cerebellum

Sho Kakizawa1, 2, 3, Toshiko Yamazawa2, Takashi Murayama4, Hideto Oyamada5, Nagomi Kurebayashi4, Masahiko Watanabe6, Nozomu Mori3, Katsuji Oguchi5, Takashi Sakurai4, Hiroshi Takeshima1, Masamitsu Iino2
1Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ., 2Dept. Pharmacol., Grad. Sch. Med., Uiv. Tokyo, 3Dept. Neuroanat., Grad. Sch. Biomed. Sci., Nagasaki Univ., 4Dept. Pharmacol., Juntendo Univ. Sch. Med., 5Dept. Pharmacol., Sch. Med., Showa Univ., 6Dept. Anat., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 104-104, 2012.

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O2C2-2-2 Another pathway to produce hydrogen sulfide in the brain

Norihiro Shibuya1, Mari Ishigami2, Makiko Tanaka1, Yuka Kimura1, Yuki Ogasawara3, Kiyoshi Fukui4, Hideo Kimura1
1Dept. Mol. Pharm., Natl. Inst. Neurosci., NCNP, 2Grad. Sch. Biomed. Sci., Tokyo Medical and Dental Univ., 3Dept. Hygienic Chemistry, Meiji Pharm. Univ., 4Inst. Enzyme Res., Tokushima Univ.
Journal of Pharmacological Sciences 118 (suppl) 104-104, 2012.

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O2C2-2-3 Hydrogen sulfide prevents neuronal cell death by increasing glutathione production and suppressing oxidative stress in mitochondria.

Yuka Kimura1, Yu-ichi Goto2, Hideo Kimura1
1Dept. Mol. Pharm., Natl. Inst. Neurosci., NCNP, 2Dept. Metal Retard. & Birth Defect, Natl. Inst. Neurosci., NCNP
Journal of Pharmacological Sciences 118 (suppl) 104-104, 2012.

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O2C2-2-4 Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide

Hideo Kimura1, Yoshinori Mikami1, Norihiro Shibuya1, Yuka Kimura1, Noriyuki Nagahara2, Yuki Ogasawara3
1Dept. Mol. Pharmacol. Natl. Inst. Neurosci. NCNP, 2Nippon Med. Sch., 3Meiji Pharmaceu. Univ.
Journal of Pharmacological Sciences 118 (suppl) 104-104, 2012.

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O2C2-3-1 Inter-pyramidal spike transmission stabilizes the sparseness of recurrent network activity

Naoko Honma, Takuya Sasaki, Daisuke Ishikawa, Kentaro Tao, Naoya Takahashi, Genki Minamisawa, Sakiko Ujita, Norio Matsuki, Yuji Ikegaya
Lab Chem Pharmacol, Grad Sch Pharma Sci, Univ of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 105-105, 2012.

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O2C2-3-2 Myosin-II-dependent translocation of drebrin at the early phase of synaptic plasticity

Tomoaki Shirao, Toshiyuki Mizui, Yuta Ishizuka, Hiroyuki Yamazaki, Nobuhiko Kojima, Yuko Sekino
Dept. Neurobiology and Behavior, Gunma Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 105-105, 2012.

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O2C2-3-3 Low density lipoprotein receptor-related protein-1 mediates the neuroprotection of apolipoprotein E-containing lipoproteins against glutamate neurotoxicity

Hideki Hayashi
Priority Org. Innov. Excel., Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 105-105, 2012.

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O2C2-3-4 Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex.

Abu Syed MD Anisuzzaman, Atsusi Nishimune, Hatsumi Yoshiki, Junsuke Uwada, Ikunobu Muramatsu
Dept. Pharmacol., Fukui Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 105-105, 2012.

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O2C2-4-1 Inhibition of Na, K-ATPase activity by fluorine and beryllium

Yuuichirou Okino, Yoshiaki Deyama, Yoshitaka Yoshimura, Kuniaki Suzuki
Mol. Cell Pharmacol., Dept. Oral Pathobiol., Grad. Sch. Dent. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 106-106, 2012.

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O2C2-4-2 Membrane-anchored FGF-2 is essential for survival of endothelial cells.

Maki Yamaguchi1, Masayuki Shiota1, Masako Tanaka1, Mayuko Oka1, Yasukatsu Izumi1, Katsuyuki Miura1, Yasuyuki Ohkawa2, Hiroshi Iwao1
1Dept. Pharmacol., Osaka City Univ., Grad. Sch. Med., 2Div. Epigenetics, Kyushu Univ., Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 106-106, 2012.

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O2C2-4-3 Na+/H+ exchanger NHE1 activates calcineurin/NFAT pathway via direct interaction of calcineurin A subunit with NHE1

Takashi Hisamitsu, Shigeo Wakabayashi
Dep. of Mol. Physiol., Natl. Cer. Cadiovas. Ctr.
Journal of Pharmacological Sciences 118 (suppl) 106-106, 2012.

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O2C2-4-4 Mechanisms underlying ATP release in urothelium upon stimulation with stretch

Hiroshi Nakagomi1, Tsutomu Mochizuki1, Tatsuya Miyamoto1, Yoshinori Moriyama2, Masayuki Takeda1, Schuichi Koizumi3
1Dept. Urology., Interdisciplinary Grad. Sch., Medicine and Engineering, Univ. Yamanashi, 2Dept. Membrane Biochemistry., Grad. Sch., Medicine, Dentistry, and Pharmaceutical Sciences, Okayama Univ., 3Dept. Neuropharmacol., Interdisciplinary Grad. Sch., Medicine and Engineering, Univ. Yamanashi
Journal of Pharmacological Sciences 118 (suppl) 106-106, 2012.

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O2C2-5-1 Cathepsin E elicits itch-related response through the endothelin-1-mediated pathway in mice

Tetsuro Yoshida, Tsugunobu Andoh, Yasushi Kuraishi
Dept. Applied Pharmacol., Sch. Med. Pharm. Sci., Univ. Toyama
Journal of Pharmacological Sciences 118 (suppl) 107-107, 2012.

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O2C2-5-2 Involvement of mast cells in gastrin-releasing peptide-induced itch-related response in mice

Tsugunobu Andoh, Takashi Kuwazono, Yasushi Kuraishi
Dept. Applied Pharmacol., Sch. Med. Pharm. Sci., Univ. Toyama
Journal of Pharmacological Sciences 118 (suppl) 107-107, 2012.

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O2C2-5-3 Effects of GABAA receptor antagonists and an L-type voltage-gated calcium channel agonist on ethanol-and barbiturate-induced aggravation of scratching response in hairless mice with atopic dermatitis

Masanori Fujii, Kaori Takeuchi, Asuka Iwai, Takanori Nakayama, Keisuke Doi, Takeshi Nabe
Dept. Pharmacol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 107-107, 2012.

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O2C2-5-4 Compensatory function of Rac isoforms in keratinocytes

Mio Nakatsuji1, Aya Shimizu1, Megumi Sakuma1, Takashi Nakamura1, Mizuho Sakahara2, Atsu Aiba2, Naoaki Saito1
1Lab. of Mol. Pharmacol., Biosignal. Res. Ctr., Kobe Univ., 2Center for Disease Biology and Integrative Medicine, Faculty of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 107-107, 2012.

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O2C2-5-5 RU486 (Mifepristone) improved Diet-induced insulin resistance by increasing blood level of adiponectin.

Takeshi Hashimoto1, Junsuke Igarashi1, Arif Hasan2, Yukiko Nagai3, Tetsuo Yamashita1, Hiroaki Kosaka1
1Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa Univ., 2Dept. Cardiorenal Cerebrovascular Med., Kagawa Univ., 3Life Science Research Center, Kagawa Univ.
Journal of Pharmacological Sciences 118 (suppl) 108-108, 2012.

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O2C2-5-6 Increased expression of the histamine H4 receptor subtype in hypertrophic differentiation of chondrogenic ATDC5 cells

Katsunori Yamaura, Seri Akiyama, Koichi Ueno
Dept. Geriat. Pharmacol. Therapeut., Grad. Schl. Pharmaceut. Sci. Chiba Univ.
Journal of Pharmacological Sciences 118 (suppl) 108-108, 2012.

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O3B1-1-1 The relationship between the amount of [11C] donepezil binding to brain acetylcholine esterase and the treatment efficacy of donepezil hydrochloride in the patients with Alzheimer's disease

Nobuyuki Okamura1, Masashi Kasuya2, Hiroyasu Ishikawa2, Naofumi Tanaka2, Yoshihito Funaki3, Ren Iwata3, Kenichi Meguro2, Kazuhiko Yanai1
1Dept. Pharmacol., Tohoku Univ. Sch. Med., 2Dept. Geriatr. Behav. Neurol., Tohoku Univ. Sch. Med., 3CYRIC, Tohoku Univ.
Journal of Pharmacological Sciences 118 (suppl) 108-108, 2012.

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O3B1-1-2 A novel Alzheimer disease therapeutics, ST101 enhances cortical long-term potentiation through T-type voltage-gated calcium channel.

Shigeki Moriguchi, Norifumi Shioda, Yui Yamamoto, Hideaki Tagashira, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 108-108, 2012.

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O3B1-1-3 Tandospirone suppresses impulsive action in rats

Yu Ohmura, Haruko Kumamoto, Iku Tsutsui-Kimura, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
Dept. Neuropharmacol., Hokkaido Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 109-109, 2012.

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O3B1-1-4 Toll-like receptor 7-mediated signaling enhances contextual fear memory in mice

Yasunori Kubo, Yoshiki Yanagawa, Machiko Matsumoto, Sachiko Hiraide, Hiroko Togashi
Dept. Phamacol., Fac. of Pharm. Sci., Health Sci. Univ. of Hokkaido
Journal of Pharmacological Sciences 118 (suppl) 109-109, 2012.

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O3B1-1-5 Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice

Yoko Furukawa-Hibi1, Tursun Alkam1, Atsumi Nitta2, Akihiro Matsuyama1, Kazuhiko Suzuki3, Nigel Greig4, Taku Nagai1, Kiyofumi Yamada1
1Dept. of Neuropsychopharm. and Hosp. Pharm., Nagoya Univ. Grad. Sch. of Med., 2Dept of Pharm. Therapy & Neuropharm., Faculty of Pharm., Sci., Univ. of Toyama., 3Translational Sci., Novartis Pharma KK., 4Drug Design and Dev. Section, Lab. of Neurosci., NIA, NIH, USA
Journal of Pharmacological Sciences 118 (suppl) 109-109, 2012.

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O3B1-2-1 Effect of mirtazapine on neuropathic pain using functional magnetic resonance imaging

Makoto Yanase1, Tatsuya Enomoto1, 2, Tomohiko Takada1, 2, Hiroshi Horiuchi1, Akira Yamashita1, Masako Iseki2, Minoru Narita1, 2
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Dept. Anesthesiol and pain., Juntendo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 109-109, 2012.

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O3B1-2-2 Studies on drug dependence (Rept. 457)： Effects of benzodiazepines on morphine induced hyperlocomotion accompanied by the changes of potassium chloride cotransporter 2 (KCC2) in mesolimbic system.

Daiki Masukawa, masahiro shibasaki, Tomohisa Mori, Kazunori Ishii, Yusuke Saito, Yui Yamagishi, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 110-110, 2012.

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O3B1-2-3 Synaptic potentiation in the nociceptive amygdala of diabetic mice with neuropathic pain

Toshitaka Ochiai1, 2, Yukari Takahashi2, Megumi Asato1, Ayako M Watabe2, 4, Masahiro Ohsawa3, Junzo Kamei1, Fusao Kato2
1Dept. Pathophysiol Therap., Sch. Pharm Pharmaceut Sci. Hoshi Univ., 2Lab Neurophysiol. Dept. Neurosci., Jikei Univ. Sch. Med., 3Lab CNS Pharmacol., Grad Sch. Pharmaceut Sci. Nagoya City Univ., 4PRESTO, JST.
Journal of Pharmacological Sciences 118 (suppl) 110-110, 2012.

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O3B1-2-4 Olanzapine-induced hyperglycemia is mediated by hepatic glyconeogenesis through the activation of hypothalamic AMPK

Takahiro Ohashi1, Megumi Asato1, Hisae Kobayashi1, Hiroko Ikeda1, Atsuko Kamei2, Junzo Kamei1
1Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Mine Pharmacy
Journal of Pharmacological Sciences 118 (suppl) 110-110, 2012.

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O3B1-2-5 Reduced mastication induces memory impairment and functional changes in activities of the hippocampus

Hiroko Ikuda1, Hironori Saisu2, Michiko Narita2, Satoshi Imai3, Noriaki Koshikawa4, Tsutomu Suzuki5, Junzo Kamei1, Minoru Narita2
1Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 3Dept. Neural Pain Sci., Univ. Maryland Sch. Dent., 4Dept. Pharmacol., Nihon Univ. Sch. Dent., 5Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 110-110, 2012.

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O3B1-3-1 Endothelin-1 increases astroglial production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 via phosphorylation of Sp1

Shotaro Michinaga, Tadateru Sawamura, Yutaka Koyama
Laboratory of Pharmacology Faculty of Pharmacy
Journal of Pharmacological Sciences 118 (suppl) 111-111, 2012.

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O3B1-3-2 Neuroprotective effects of serotonin-1a agonist 8-OH-DPAT in parkinsonian mice

Ikuko Miyazaki, Shinki Murakami, Mika Takeshima, Masato Asanuma
Dept. of Brain Sci., Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 111-111, 2012.

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O3B1-3-3 Brain pericytes-specific TNF-α-induced MMP-9 release is mediated by ROS and delayed activation of ERK1/2 and Akt

Takashi Machida1, Shinya Dohgu1, Fuyuko Takata1, 2, Junichi Matsumoto1, Hiroyuki Takahashi1, Haruki Miyaji1, Yui Sonogi1, Atsushi Yamauchi1, Yasufumi Kataoka1, 2
1Dept. Pharm. Care Health Sci., Fac. Pharm. Sci., Fukuoka Univ., 2PharmaCo-Cell Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 111-111, 2012.

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O3B1-3-4 Brain pericytes prevent migration of the inflammatory cells across the blood-brain barrier

Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Hiroyuki Takahashi, Takashi Machida, Natsuko Ichiki, Natsuko Seki, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharm. Care Health Sci., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 111-111, 2012.

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O3B1-3-5 Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

Fuyuko Takata1, 2, Shinya Dohgu1, junichi Matsumoto1, Takashi Machida1, Hiroyuki Takahashi1, Atsushi Yamauchi1, Yasufumi Kataoka1, 2
1Dept. Pharm. Care. Health Sci., Fac. Pharm. Sci., Fukuoka Univ., 2PharmaCo-Cell Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 112-112, 2012.

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O3B1-4-1 Behavioral Pharmacology of plant-derived substances (24)： Search on possible target molecules for menthol

Toyoshi Umezu
Center Environm. Measure. Analys., Natl. Inst. Environm. Studies
Journal of Pharmacological Sciences 118 (suppl) 112-112, 2012.

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O3B1-4-2 Cell-based chemical screen identifies a novel type of kinase inhibitor that targets autophosphorylation of the kinase DYRK1A

Isao Kii1, Yukiko Okuno1, Yuto Sumida2, Takamitsu Hosoya2, Masatoshi Hagiwara1
1Dept. Anat. Dev. Biol., Grad. Sch. Med., Kyoto Univ., Faculty of medicine Bldg., 2Lab. Chem. Biol., Inst. Biomat. Bioeng., Tokyo Med. Dent. Univ.
Journal of Pharmacological Sciences 118 (suppl) 112-112, 2012.

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O3B1-4-3 Psychological and learning disorders in hippocampal neuron-specific HB-EGF deficient mice

Keita Sasaki, Hiroshi Ueda
Div. Mol. Pharmacol. & Neurosci. Nagasaki Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 112-112, 2012.

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O3B1-4-4 Tetrahydrobiopterin deficiency disturbs postnatal development of the monoaminergic nervous system

Chiho Sumi-Ichinose, Yui Suganuma, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo
Dept. Pharmacol., Sch. Med., Fujita Health Univ.
Journal of Pharmacological Sciences 118 (suppl) 113-113, 2012.

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O3B1-4-5 Attention-deficit like behavior and the responsiveness to psychostimulant of diacylglycerol kinase β knockout mice

Mitsue Ishisaka, Atsushi Oyagi, Kenichi Kakefuda, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 118 (suppl) 113-113, 2012.

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O3B1-5-1 Vagal dysfunction promotes the sensitivity of lumbar Aδ primary afferent neurons in rats

Sadayoshi Furuta1, 2, 3, Lisa Watanabe1, Seira Doi1, Hiroshi Horiuchi2, Kenjiro Matsumoto1, 2, 4, Tsutomu Suzuki1, Minoru Narita2
1Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 3Dept. DDR. Kaken Pharmaceutical Co.,Ltd., 4Dept. Pharmacol., Fac. Pharm. Sci., Josai Int. Univ.
Journal of Pharmacological Sciences 118 (suppl) 113-113, 2012.

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O3B1-5-2 Multiple analyses of histone modification in the spinal cord under a neuropathic pain-like state

Daigo Ikegami1, Akitoshi Date1, Michiko Narita1, Satoshi Imai1, Hideyuki Takeshima2, Katsuhide Igarashi3, Jun Kanno3, Toshikazu Ushijima2, Minoru Narita1
1Dept. of Pharmacol., Hoshi Univ. Sch. of Pharm. and Pharmaceut. Sci., 2Div. Epigenomics, Natl. Cancer Ctr, Res. Inst., 3Div. Cell. Mol. Tox., BSRC, Natl. Inst. Health Sci.
Journal of Pharmacological Sciences 118 (suppl) 113-113, 2012.

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O3B1-5-3 The utility of combination of an atypical antipsychotic olanzapine with morphine for pain management

Kazuhiro Torigoe1, Kae Nakahara1, Rahamadi Mahardian1, Shigeto Hirayama3, Akira Yamashita2, Hiroshi Horiuchi2, Masahiro Shibasaki1, Tomohisa Mori1, Hiroshi Nagase3, Motohiro Matoba4, Tsutomu Suzuki1, Minoru Narita2
1Dept. Toxicol., Hoshi Univ. Sch. Pharm. Phgarmaceut. Sci., 2Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 3Dept. Medicinal Chem., Kitasato Univ. Sch. Pharmaceut. Sci., 4Palliative Med. Psycho-Oncol. Div., NCCH.
Journal of Pharmacological Sciences 118 (suppl) 114-114, 2012.

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O3B1-5-4 Possibility of miRNAs derived from blood exosomes as diagnostic biomarkers for neuropathic pain

Hiroshi Horiuchi1, Michiko Narita1, Hiroyasu Sakai1, Daigo Ikegami1, Takahiro Ochiya2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Div. Mol. Cell. Med., Natl. Cancer Ctr. Res. Inst.
Journal of Pharmacological Sciences 118 (suppl) 114-114, 2012.

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O3B1-5-5 Changes of miRNA in the amygdala under the neuropathic pain.

Hironori Saisu1, 2, Hiroshi Horiuchi1, Akira Yamashita1, Kouichi Wajima2, Taneaki Nakagawa2, Hiroyasu Sakai1, Daigo Ikegami1, Minoru Narita1
1Dept Pharmacol, Hoshi Univ Sch Pharm Pharmaceaut Sci, 2Dept Dent and Oral Surg, Keio Univ Sch Med
Journal of Pharmacological Sciences 118 (suppl) 114-114, 2012.

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O3B2-1-1 Neuroprotective effect of Pioglitazone on 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model for Parkinson's disease

Jiro Kasahara, Tatsuya Tsukada, Hayato Kuroiwa, Shinji Okabe, Tatsuya Fukano, Hiroto Uchida, Hironori Yokoyama
Dept. Neurobiol. Therapeu., Grad. Sch. Pharmaceu. Sci., Univ. Tokushima
Journal of Pharmacological Sciences 118 (suppl) 114-114, 2012.

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O3B2-1-2 Therapeutic effect of zonisamide on the nigrostriatal dopaminergic neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced mice model of Parkinson's disease.

Hironori Yokoyama, Misato Matsueda, Ryouhei Yano, Jiro Kasahara
Dept Neurobiol Therapeu, Grad Sch Pharmaceu, Univ Tokushima
Journal of Pharmacological Sciences 118 (suppl) 115-115, 2012.

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O3B2-1-3 Ameliorative effects of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, against the development of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats

Yuki Ota1, Kazuhiro Takuma1, Tsuyoshi Takahashi1, Yukio Ago1, Toshio Matsuda1, 2
1Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2United Grad. Sch. of Child Dev., Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 115-115, 2012.

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O3B2-1-4 ALS-linked mutant VAPB enhances TDP-43-induced motor neuronal toxicity

Hiroaki Suzuki, Masaaki Matsuoka
Dept. Pharmacol., Tokyo Med, Univ.
Journal of Pharmacological Sciences 118 (suppl) 115-115, 2012.

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O3B2-1-5 Reduced expression of BTBD10 in spinal motor neurons is one of the causes of motoneuronal death and drives progression of ALS

Mikiro Nawa1, Eriko Kage-Nakadai2, 3, Sadakazu Aiso4, Koichi Okamoto5, Shohei Mitani2, 3, Masaaki Matsuoka1
1Dept. Pharmacol., Tokyo Med. Univ., 2Dept. Physiol., Tokyo Women's Med. Univ Sch. Med., 3CREST, 4Dept. Anat., KEIO Univ. Sch. Med., 5Dept. Neurol., Gunma Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 115-115, 2012.

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O3B2-2-1 Regulation of mitochondrial functions through a novel sigma-1 receptor and neuronal apoptosis.

Norifumi Shioda, Kiyoshi Ishikawa, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 116-116, 2012.

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O3B2-2-2 Therapeutic Effects of Retinoids on Intracerebral Hemorrhage in Mice

Hideaki Matsushita1, Masanori Hijioka1, Tetsuhiro Uematsu1, Akinori Hisatsune1, Yoichiro Isohama1, Shigeto Iwamoto2, Hiroaki Terasawa2, Koichi Shudo3, Hiroshi Katsuki1
1Dept. Chemico-Pharmacol. Sci., Grad. Pharm. Sci. Kumamoto Univ., 2Dept., Struct. -Func. Phys. Chem., Grad. Sch. Pharm. Sci. Kumamoto Univ., 3Res. Fdn. ITSUU Lab.
Journal of Pharmacological Sciences 118 (suppl) 116-116, 2012.

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O3B2-2-3 Capsaicin reduces neuronal cell death induced by NMDA via stimulation of opioid receptor in the rat retina

Kenji Sakamoto, Taiyo Kuroki, Haruna Sekiya, Akihiro Watanabe, Asami Mori, Tsutomu Nakahara, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 116-116, 2012.

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O3B2-2-4 Excitotoxicity-induced biphasic prostaglandin production has remote effect on long-lasting progressive neuronal death

Keisuke Yoshikawa1, Yoshihiro Kita3, Ayako Furukawa2, Kei Maruyama1, Takao Shimizu3, Atsuyoshi Shimada2
1Dept. Pharmacol., Saitama Med Univ. Sch. Med., 2Dept of Pathol. Inst. for Developmental Res. Aichi Prefectural Colony, 3Dept of Biochem. Tokyo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 116-116, 2012.

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O3B2-2-5 Cytoprotective effect of hydrogen sulfide on light-induced retinal degeneration

Yoshinori Mikami1, Norihiro Shibuya1, Yuka Kimura1, Noriyuki Nagahara2, Masahiro Yamada3, Hideo Kimura1
1Dept. Mol. Pharmacol., Natl. Inst. Neurosci., NCNP., 2Dept. Environ. Med., Nippon Med. Sch., 3Neuroinformatics, RIKEN BSI.
Journal of Pharmacological Sciences 118 (suppl) 117-117, 2012.

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O3B2-3-1 Delayed neuronal death of the granular cells in the rat hippocampal dentate gyrus associated with aggravation of anhedonia after the transient focal cerebral ischemia.

Hiroto Uchida, Yuki Fujita, Jiro Kasahara
Dept. Neurobiol. Therapeu., Grad. Sch. Pharmaceu. Sci., Univ. Tokushima
Journal of Pharmacological Sciences 118 (suppl) 117-117, 2012.

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O3B2-3-2 Modulation of olfactory neuroblast migration by heparan sulfate

Shin-ichi Murase, Hiroshi Higuchi
Dept. Pharmacol., Niigata Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 117-117, 2012.

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O3B2-3-3 Protein kinase CK2 regulates the formation and clearance of aggresomes

Masahiko Watabe, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 117-117, 2012.

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O3B2-3-4 Dysfunction in endoplasmic reticulum (ER) protein by S-nitrosylation/oxidation.

Mari Shibata, Tadashi Nishiya, Takashi Uehara
Dept. Med. Pharmacol., Grad. Sch. Med., Dent. & Pharm. Sci., Okayama Univ.
Journal of Pharmacological Sciences 118 (suppl) 118-118, 2012.

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O3B2-4-1 Nicotine induces dendritic spine remodeling in cultured hippocampal neurons

Akira Oda1, 2, Kanato Yamagata3, Ryuichi Ohgaki2, Shushi Nagamori2, Yoshikatsu Kanai2, Hidekazu Tanaka2, 3
1CNS DDU, Takeda Pharmaceutical Company, 2Dept. Pharmacol., Osaka Univ. Sch. Med., 3Tokyo Metropolitan Institute Medical Sciences
Journal of Pharmacological Sciences 118 (suppl) 118-118, 2012.

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O3B2-4-2 Mental retardation/Autism spectrum disorder related gene product IL1RAPL1 regulates membrane trafficking of the AMPA receptor in glutamatergic synapses

Takashi Hayashi, Tomoyuki Yoshida, Masayoshi Mishina
Dept. Mol. Neurobiol. and Pharmacol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 118-118, 2012.

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O3B2-4-3 Signal Crosstalk and complex formation of adenosine A1 receptor and mGluR1

Yuji Kamikubo, Takashi Sakurai
Dept. of Pharmacol., Sch. of Med., Juntendo Univ.
Journal of Pharmacological Sciences 118 (suppl) 118-118, 2012.

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O3B2-4-4 NMDA neurotoxicity mediated by mitochondrial uncoupling protein-2

Ryo Fukumori, Takeshi Takarada, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech.
Journal of Pharmacological Sciences 118 (suppl) 119-119, 2012.

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O3B2-4-5 Functional analysis of the glutamine transporter slc38a1 in brain

Aya Sako, Takeshi Takarada, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech
Journal of Pharmacological Sciences 118 (suppl) 119-119, 2012.

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O3B2-5-1 Effect of injection of neural progenitor cells on depressive like behavior after cerebral ischemia

Yoshiyuki Moriyama, Norio Takagi, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci.
Journal of Pharmacological Sciences 118 (suppl) 119-119, 2012.

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O3B2-5-2 Combined activation of 5-HT1A and σ1 receptors enhances prefrontal dopamine release under circulating neuroactive steroid-deficient conditions

Naoki Hiramatsu1, Yukio Ago1, Koji Yano1, Kazuhiro Takuma1, Toshio Matsuda1, 2
1Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ., 2United Grad. Sch. of Child Dev., Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 119-119, 2012.

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O3B2-5-3 Chronic treatment with cocaine induces presynaptic plasticity in rat brainstem cholinergic neurons

Ryo Kurasawa, masabumi Minami, Katsuyuki Kaneda
Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 120-120, 2012.

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O3B2-5-4 Intracellular localization and brain distribution of TMEM168, isolated from the nucleus accumbence in methamphetamine-treated mice

Kanako Takayama, Yoshiaki Miyamoto, Kyosuke Uno, Seunghee Seo, Shohei Matsumura, Junko Wada, Atsumi Nitta
Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Journal of Pharmacological Sciences 118 (suppl) 120-120, 2012.

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O3C1-1-1 Combination effects of gamma tocotrienol and stain against malignant mesothelioma

Hiromi Sato1, Saki Ichinomiya1, Tuerdi Guligena1, Tomohiro Yano2, Koichi Ueno1
1Dept. of Geriatric Pharamacology and Therapeutics, Grad. Sch. of Pharaceceut. Sci., Chiba Univ., 2Lab of Molecular Patho-physiology, Faculty of Life Sci., Toyo Univ.
Journal of Pharmacological Sciences 118 (suppl) 120-120, 2012.

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O3C1-1-2 Role of c-Myc for regulation of LAT1 in cancer cells

Keitaro Hayashi1, Promsuk Jutabha1, Hitoshi Endou2, Naohiko Anzai1
1Dept. Pharmacol. and toxicol., Dokkyo Med. Univ., Sch. Med., 2J-Pharma Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 120-120, 2012.

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O3C1-1-3 AMPK activator, metformn, enhances anti-tumor effect of a system L amino acid transporter (LAT1) inhibitor

Seiji Ueno, Toru Kimura, Takashi Yamaga, Hiroyuki Sakurai
KYORIN Univ.
Journal of Pharmacological Sciences 118 (suppl) 121-121, 2012.

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O3C1-1-4 Inhibitor induced conformational modulation of target kinases

Naoki Watanabe, Yunfeng Yuan, Masahiro Maruoka
Lab. Single-Molecule Cell Biol., Tohoku Univ. Grad. Sch. Life Sci.
Journal of Pharmacological Sciences 118 (suppl) 121-121, 2012.

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O3C1-1-5 Inhibition of immature protein sensor Bag1-mediated BCR-ABL degradation by Hsp90-cdc37 chaperone

Fujiko Tsukahara, Yoshiro Maru
Dept. Pharmacol., Tokyo Women's Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 121-121, 2012.

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O3C1-2-1 Deficient of GSNO reductase compromises expression of the ER stress-related proteins in LPS-treated liver.

Kentaro Ozawa1, Hiroki Tsumoto1, Akira Komatsubara2, Hiroto Kawahune2, Gozo Tsujimoto1, 2
1Dept. Pharm., Kyoto Univ., 2Dept. Genomic Drag, kyoto Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 121-121, 2012.

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O3C1-2-2 Activation of TRPM8 channels augments invasive potential of oral carcinoma cell lines

Yoshihiko Okamoto1, Tsuyako Ohkubo2, Kazuhiko Okamura3, Tetsuro Ikebe1, Jun Yamazaki2
1Dept. Oral & Maxillofa. Surg., Fukuoka Dent. Coll., 2Dept. Physiol. Sci. Mol. Biol., Fukuoka Dent. Coll., 3Dept. Morphol. Biol., Fukuoka Dent. Coll.
Journal of Pharmacological Sciences 118 (suppl) 122-122, 2012.

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O3C1-2-3 Evaluation of the patterns of brain metastases using BBB Kit.

Kunihiko Tanaka1, Yutaka Tagawa2, 3, Masami Niwa1, 3
1Dept. Pharmacol., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2Dept. Nur. Nagasaki Univ. Grad. Sch. Biomed. Sci., 3PharmaCo-Cell Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 122-122, 2012.

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O3C1-2-4 The anti-tumor effect of cordycepin on human HT1080 fibrosarcoma cells via the reduction of matrix metalloproteinase-2 and cyclin D1 expression

Mami Kakuda1, Noriko Yoshikawa1, Yuta Takahashi1, Youko Kimoto1, Masaru Kunitomo1, Satomi Kagota2, Kazumasa Sinozuka2, Kazuki Nakamura1
1Dept. Pharmacol. I, Mukogawa Women's Univ. Sch. Pharm., 2Dept. Pharmacol. II, Mukogawa Women's Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 122-122, 2012.

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O3C1-2-5 Endogenous hydrogen sulfide contributes to cell proliferation in gastric cancer cells

Fumiko Sekiguchi, Teruki Sekimoto, Atsufumi Kawabata
Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 122-122, 2012.

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O3C1-3-1 Roles of VEGFR1 signaling in compensatory lung growth after unilateral pneumonectomy.

Yoshio Matsui1, Hideki Amano1, Fumihiro Ogawa1, 2, Yukitoshi Satoh2, Masataka Majima1
1Dept. Pharmacol., Kitasato Univ. Sch. Med., 2Dept. Thorac. Surg., Kitasato Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 123-123, 2012.

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O3C1-3-2 Involvement of β-adrenoceptor on differentiation of mouse induced pluripotent stem cells into neural progenitor cells

Toshiaki Ishizuka, Ayako Ozawa, Haduki Goshima, Yasuhiro Watanabe
Dept. Pharmacol. Natl. Def. Med. Col.
Journal of Pharmacological Sciences 118 (suppl) 123-123, 2012.

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O3C1-3-3 Control mechanism of gefitinib-resistant human non-small-cell lung cancer (NSCLC) cells growth and transformation by stimulation of δ-opioid receptors

Atsumi Nagasawa1, Naoko Kuzumaki1, 2, Michiko Narita1, Hideyuki Okano2, Minoru Narita1
1Dept. Pharamcol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., Tokyo, 2Dept. Physiol., Keio Univ. Sch. Med. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 123-123, 2012.

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O3C1-3-4 The kappa opioid system regulates endothelial cell differentiation and pathfinding in vascular development

Yusuke Hamada1, Kohei Yamamizu2, Naoko Kuzumaki1, 3, Michiko Narita1, Jun Yamashita2, Minoru Narita1
1Dept. Pharamcol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Laboratory of Stem Cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University, 3Dept. Physiol., Keio Univ. Sch. Med. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 123-123, 2012.

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O3C1-3-5 Usefulness of human disease-specific iPS cells research for understanding of age-related higher brain dysfunction

Naoko Kuzumaki1, 2, Michiko Narita2, Yukari Suda2, Atsumi Nagasawa2, Yusuke Hamada2, Wado Akamatsu1, Yohei Okada1, Hirotaka Okano James1, 3, Hideyuki Okano1, Minoru Narita2
1Dept. Physiol., Keio Unv. Sch. Med., 2Dept. Pharamcol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 3Div. Regenerative Med. Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 124-124, 2012.

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O3C1-4-1 A novel GDP-bound-Rab27a-interacting protein which determines the intracellular localization of Rab27a and coronin3

Toshihide Kimura, Mami Yamaoka, Shigeki Taniguchi, Ichiro Niki
Dept. of Pahrmacology, Oita Univ. Fac. of Med.
Journal of Pharmacological Sciences 118 (suppl) 124-124, 2012.

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O3C1-4-2 Regulation of IL-17 expression by p38 in the pathogenesis of experimental autoimmune encephalomyelitis.

Kana Namiki1, Hirofumi Matsunaga2, Kento Yoshioka1, Kensuke Tanaka1, 3, Jyunji Ishida4, Tatsuhiko Sudo5, Akiyoshi Fukamizu4, Sadao Kimura1, Yoshitoshi Kasuya1
1Dept. Biochem. Mol. Pharmacol., Chiba Univ. Sch. Med, 23Ube Industries, Ltd, 3Dept. of Respirol, Grad. School of Med., Chiba Univ, 45Life Science Center of TARA, Tsukuba Univ, 5Dept. of Antibiotics, RIKEN
Journal of Pharmacological Sciences 118 (suppl) 124-124, 2012.

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O3C1-4-3 Assembly and function of the TCR- and dynein-super complex critical for TCR microcluster movement and immune synapse formation

Akiko Hashimoto-Tane, Machie Sakuma, Tadashi Yokosuka, Takashi Saito
RIKEN RCAI Cell signaling
Journal of Pharmacological Sciences 118 (suppl) 124-124, 2012.

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O3C1-5-1 Roles of junctophilin 1 and 2 in junctional membrane-targeting of L-type calcium channels and ryanodine receptors.

Tsutomu Nakada1, Bernhard Flucher2, Toshihide Kashihara1, Xiaona Sheng1, Toshihide Shibazaki1, Simmon Gomi1, Mitsuhiko Yamada1
1Dept. of Mol. Pharmacol., Shinshu Univ. Sch. of Med., 2Dept. Pysiol. Med. Phys., Innsbruck Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 125-125, 2012.

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O3C1-5-2 The S4-S5 linker of the type 1 ryanodine receptor regulates channel gating

Takashi Murayama1, Nagomi Kurebayashi1, Toshiharu Oba2, Hideto Oyamada3, Katsuji Oguchi3, Yasuo Ogawa1, Takashi Sakurai1
1Dept. Pharmacol., Juntendo Univ. Sch. Med., Tokyo, 2Dept. Cell Physiol., Nagoya City Univ. Grad. Sch. Med. Sci., 3Dept. Pharmacol., Showa Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 125-125, 2012.

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O3C1-5-3 Distribution of TAS2R108 in various tissues and its physiological function

Hiroyasu sakai1, Kenji Todoroki1, Nanoka Sasaki1, Yusuke Ueda1, Mai Honda1, Atsunobu Sagara1, Maiko Nishizaki1, Satoshi Hasegawa1, Ken Sato1, Tetsuro Syoji1, Kenjiro Matsumoto1, 3, Syunji Horie3, Yoshihiko Chiba2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ., 2Dept. Biol., Hoshi Univ., 3Lab. Pharmacol., Fac. Pharmaceut. Sci., Josai International Univ.
Journal of Pharmacological Sciences 118 (suppl) 125-125, 2012.

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O3C1-5-4 Novel inhibitory effect of G protein-coupled receptor kinases (GRKs) on adrenomedullin (AM) signaling

Kenji Kuwasako1, Kazuo Kitamura2, Sayaka Nagata2, Naomi Nozaki1, Johji Kato1
1Frontier Sci. Res. Center, Univ. of Miyazaki, 2Circl. and Body Fluid Reg., Faculty of Med., Univ. of Miyazaki
Journal of Pharmacological Sciences 118 (suppl) 125-125, 2012.

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O3C2-1-1 Involvement of the down-regulation of α1)-adrenergic receptor in age-related impairment of liver clock entrainment

Takahiro Moriya1, Shingo Nakashima1, Hiroshi Onozuka1, Yohei Saito2, Tomonori Kobayashi2, Fumihiko Yamamoto2, Hidenobu Ohta3, Hajime Tei4, Yasuhito Ohkubo2, Norimichi Nakahata1
1Dept. Cell. Signal., Grad. Sch. Pharm. Sci., Tohoku Univ, 2Dept. Radiopharm., Tohoku Pharm. Univ., 3Dept. Dev. Disorders, Nat. Ins. Mental Health, NCNP, 4Grd. Sch. Nat. Sci. Tech., Kanazawa Univ.
Journal of Pharmacological Sciences 118 (suppl) 126-126, 2012.

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O3C2-1-2 Activation of prostaglandin D receptor DP suppresses concanavalin A-induced hepatitis

Tomoko Fujita1, 2, Kitipong Soontrapa2, Shuh Narumiya1, 2
1AK Project, Kyoto Univ. Sch. Med, 2Dept. Pharmacol., Kyoto Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 126-126, 2012.

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O3C2-1-3 Role of thromboxane A2 receptor signaling in liver repair after hepatotoxicity

Tsutomu Minamino1, 2, 3, 4, Yoshiya Ito1, 3, Hirotoki Ohkubo1, 3, Kanako Hosono1, Shuh Narumiya4, Wasaburo Koizumi2, Masataka Majima1
1Dept. Pharmacol., kitasato Univ. Sch. Med, 2Dept. Gastroenterology., Kitasato Univ. Sch. Med, 3Dept. Surgery., Kitasato Univ. Sch. Med, 4Dept. Pharmacol., Kyoto Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 126-126, 2012.

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O3C2-1-4 Macrophages are regulated by urokinase-type plasminogen activator during liver repair

Naoyuki Kawao1, Nobuo Nagai2, Yukinori Tamura1, Katsumi Okumoto3, Yasuhiro Suzuki4, Kazuo Umemura4, Kiyotaka Okada1, Masato Yano1, Hiroshi Kaji1, Osamu Matsuo1
1Dept. Physiol. & Regen. Med., Kinki Univ. Fac. Med., 2Dept. Animal Biosci., Fac. Biosci., Nagahama Inst. Bio-Sci. & Tech., 3Life Sci. Res. Inst., Kinki Univ., 4Dept. Pharmacol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 126-126, 2012.

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O3C2-1-5 Periodontal pathogen, Porphyromonas gingivalis is a potential risk factor for nonalcoholic fatty liver disease.

Koichiro Wada1, Masato Yoneda2, Yoshinori Kamisaki1, Atsushi Nakajima2
1Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ., 2Gastroenterol. Div., Yokohama City Univ. Hospital.
Journal of Pharmacological Sciences 118 (suppl) 127-127, 2012.

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O3C2-2-1 Effect of H pylori infection on the gastric parietal cells in Mongolian gerbils

Mika Yamamoto1, Mayu Fukuzawa1, Kanako Hamaya1, Yoko Kuroda1, Saeko Masuyama1, Rei Takahashi1, Kikuko Amagase2, Koji Takeuchi2, Motonobu Murakami1
1Dept. Pharmacotherapy, DWCLA, Kodo, 2Dep. Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 127-127, 2012.

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O3C2-2-2 Effect of Helicobacter pylori infection on the gastric mucus cells in Mongolian gerbils

Kanako Hamaya1, Mayu Fukuzawa1, Mika Yamamoto1, Yoko Kuroda1, Saeko Masuyama1, Rei Takahashi1, Kikuko Amagase2, Koji Takeuchi2, Motonobu Murakami1
1Dept. Pharmacotherapy, DWCLA, 2Dep. Pharmacology and Experimental Therapeutics, kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 127-127, 2012.

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O3C2-2-3 Loss of the gastric adherens junction after Helicobacter pylori infection in Mongolian gerbils

Mayu Fukuzawa1, Kanako Hamaya1, Mika Yamamoto1, Yoko Kuroda1, Saeko Masuyama1, Rei Takahashi1, Kikuko Amagase2, Koji Takeuchi2, Motonobu Murakami1
1Dept. Pharmacotherapy, DWCLA, 2Dep. Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 127-127, 2012.

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O3C2-2-4 Comparative studies of TJ-14 (Hange-shashin-to) and TJ-60 (Keishika-shakuyaku-to), Japanese kampo medicines, on contractile activities of circular smooth muscles in the rat distal colon

Yoshihiko Kito1, 2, Noriyoshi Teramoto1
1Dept. Pharmacol., Saga Univ. Facul. Med., 2Dept. Physiol., Nagoya City Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 128-128, 2012.

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O3C2-2-5 Mechanisms of postprandial hyperglycemia in liver diabetic mellitus.

Kyoko Nakamura, Masaki Tabuchi, Kana Ooshima, Atsuko Niwa, Hideo Takahashi
Dept. Pharmacol. Kinki Univ. Facul. Med.
Journal of Pharmacological Sciences 118 (suppl) 128-128, 2012.

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O3C2-2-6 Ubiquitination-mediated decrease in intestinal P-glycoprotein expression under diabetic condition

Ayaka Nawa, Wakako Fujita-Hamabe, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 128-128, 2012.

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O3C2-3-1 Prevention by polyamines of bone loss in ovariectomized mice

Tomomi Yamamoto, Eiichi Hinoi, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech.
Journal of Pharmacological Sciences 118 (suppl) 128-128, 2012.

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O3C2-3-2 Maf mediates the age-related switch in mesenchymal cell differentiation

Keizo Nishikawa1, Hiroshi Takayanagi2
1iFReC, Univ. Osaka, 2Dept. Cell Signal., TMDU
Journal of Pharmacological Sciences 118 (suppl) 129-129, 2012.

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O3C2-3-3 Noradrenaline regulated potassium currents and proliferation via Gi/o-protein-coupled α1B-adrenergic receptor in human osteoblast

Daisuke Kodama, Akifumi Togari
Dept. Pharmacol., Aichi-Gakuin Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 129-129, 2012.

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O3C2-3-4 An antagonist of tumor necrosis factor-α stimulates bone formation under the lipopolysaccharide-induced inflammation in a murine tooth extraction model.

Kazuhiro Aoki1, Hiroyuki Nakachi2, Neil Alles1, Kenichi Nagano1, Masud Khan1, 3, Nobuyoshi Tomomatsu2, Ramachandran Murali4, Hongtao Zhang5, Masashi Yamashiro2, Mark I Greene5, Yukihiko Tamura1, Keiichi Ohya1
1Dept. Hard Tissue Engineering (Pharmacology), Grad. Sch. Tokyo Med & Dent Univ., 2Dept. Maxillofacial Surg., Grad. Sch. Tokyo Med & Dent Univ., 3GCOE, Tokyo Med & Dent Univ., 4Dept Biomed Sci, Cedars-Sinai Med Cent, 5Dept Pathol., Abramson Canc Res Center, Univ Pennsylvania
Journal of Pharmacological Sciences 118 (suppl) 129-129, 2012.

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O3C2-4-1 The relationship between intracellular protein phosphorylation and cytokine production in type II alveolar epithelial cells under the development of pulmonary fibrosis

Takeshi Kobayashi1, 2, Kensuke Tanaka1, 2, Hiroyuki Amano1, 2, Sadao Kimura1, Koichiro Tatsumi2, Yoshitoshi Kasuya1
1Dept. Biochemistry and Molecular Pharmacol., Chiba Univ. Sch. Med., 2Dept. Respirol., Chiba Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 129-129, 2012.

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O3C2-4-2 Cysteinyl leukotriene type 1 receptor antagonist attenuates the progression of silica-induced pulmonary fibrosis in mice

Chiko Shimbori, Naotaka Shiota, Hideki Okunishi
Dept. Pharmacol., Shimane Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 130-130, 2012.

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O3C2-4-3 Relation between membrane potential and intracellular Ca2+ concentration in mouse airway ciliated cell

Teruya Ohba, Eiji Sawada, Yoshiaki Suzuki, Hisao Yamamura, Susumu Ohya, Yuji Imaizumi
Dept. Mol & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ
Journal of Pharmacological Sciences 118 (suppl) 130-130, 2012.

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O3C2-4-4 Organ bath study of Cynomolgus monkey trachea to estimate the drug efficacy

Kazuhiko Shinagawa1, Takanobu Mochida1, Tomomi Shirai1, Hiroyuki Takamatsu1, Kazuo Umemura2
1Hamamatsu Pharma Research, Inc., 2Dept. Pharmcol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 130-130, 2012.

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O3C2-4-5 Improved method of pulmonary stem/progenitor cells isolation

Kensuke Tanaka1, 2, Hiroyuki Amano1, 2, Takeshi Kobayashi1, 2, Masahiko Hagiwara3, Sadao Kimura1, Kouichirou Tatsumi2, Yoshitoshi Kasuya1
1Dept. Biochemistry and Molecular Pharmacol., Grad. School of Med., Chiba Univ., 2Dept. of Respirol., Grad. School of Med., Chiba Univ. Med., 3Ube Industries Ltd.
Journal of Pharmacological Sciences 118 (suppl) 130-130, 2012.

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O3C2-5-1 Double-stranded RNA stimulation augments cigarette smoke-induced emphysema in mice and the role of CD8+ cells

Hikaru Katoh, Hiroyuki Tanaka, Junichi Higuchi, Yuh Kajiwara, Yoji Nagira, Naoki Inagaki
Lab., Pharmacol., Dept., Bioactive Mol., Gifu Pharm. Univ
Journal of Pharmacological Sciences 118 (suppl) 131-131, 2012.

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O3C2-5-2 Endotoxin-induced acute lung inflammation is attenuated by intranasal NF-кB decoy oligonucleotides in mice

Kengo Tomita, Ken-ichi Takano, Michinori Takashina, Hiroki Yokoo, Yuichi Hattori
Dept. Mol. Med. Pharmacol., Graduate Sch. of Med. and Pharm. Sci., Univ. of Toyama
Journal of Pharmacological Sciences 118 (suppl) 131-131, 2012.

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O3C2-5-3 Apigenin suppresses histamine H1 receptor gene expression by interaction with HSP90.

Hiroaki Nagai1, Hiroyuki Mizuguchi1, Yuki Nariai1, Yoshiyuki Yoshimura2, Noriaki Takeda3, Hiroyuki Fukui1
1Dept. Mol. Pharmacol, Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch., 2Dept. Med. Pharmacol., Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch., 3Dept. Otorhinolaryngol. Communicative Neurosci., Inst. of Health-Bioscience, The Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 131-131, 2012.

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O3C2-5-4 Development of monoclonal antibodies that block binding of NMO-IgG to AQP4

Kaori Miyazaki1, 2, Yoichiro Abe1, Takao Hamakubo3, Kazuo Fujihara4, Masato Yasui1
1Dept. Pharmacol., Keio Univ. Sch. Med., 2Dept. Orthop., Keio Univ. Sch. Med., 3Dept. Mol. Biol. Med., Research center for advanced science and technology, 4Dept. multiple sclerosis therapeutics, Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 131-131, 2012.

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O3C2-5-5 Expression of caspase-14 in stratified and cornified epithelium in a rat oral mucosal reconstruction model

Hiroshi Murakami1, Kazuhiko Okamura2, Ryuji Sakagami1, Jun Yamazaki3
1Dept. Odontol., Fukuoka Dent. Coll., 2Dept. Morphol. Biol., 3Dept. Physiol. Sci. Mol. Biol.
Journal of Pharmacological Sciences 118 (suppl) 132-132, 2012.

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P1-1-1 Immunohistochemical examination of OA1, a receptor candidate for L-3, 4-dihydroxyphenylalanine, in the CNS

Marina Kamiya, Naoya Yamashita, Yukio Sasaki, Fumio Nakamura, Yoshio Goshima
Dept of Mol Pharmacol, Yokohama City Univ
Journal of Pharmacological Sciences 118 (suppl) 134-134, 2012.

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P1-1-2 Codeine inhibits spontaneous excitatory synaptic transmission through modulation of metabotoropic glutamate receptor 1 in the guinea pig nucleus tractus solitarius slices

Yoshiaki Ohi, Satoko Kimura, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 134-134, 2012.

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P1-1-3 Effect of Dopamine on synaptic plasticity in SHRSP/Ezo medial prefrontal cortex

Shinichi Kimura1, Sachiko Hiraide2, Machiko Matsumoto2, Hiroko Togashi2, Atsuko Ohashi1, Keiichi Shimamura1
1Clini. Pharmacol., Dept. Pharmac. Sci., Health Sci. Univ. Hokkaido., 2Pathophysiol., Dept. Pharmac. Sci., Health Sci. Univ. Hokkaido
Journal of Pharmacological Sciences 118 (suppl) 134-134, 2012.

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P1-1-4 Functional imaging of molecular architecture at a presynaptic active zone

Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose
Dept. Neurobiol., Tokyo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 134-134, 2012.

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P1-1-5 Approaching the molecular basis for presynaptic function by glutamate imaging

Naoya Kimpara, Hirokazu Sakamoto, Shigeyuki Namiki, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 135-135, 2012.

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P1-1-6 A human astrocytoma-derived cell line transports dopamine through PMAT

Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomitsu Iida, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ Grad Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 135-135, 2012.

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P1-1-7 Effect of resveratrol, a red wine polyphenol, on noradrenaline transporter function

Yumiko Toyohira1, Goh Obara2, Hirohide Inagaki1, Ruka Sakamaki4, Kojiro Takahashi3, Nobuyuki Yanagihara1
1Dept. Pharmacol., Univ. Occup. & Environ. Hlth., Sch. Med., 2Dept. Anesth., Univ. Occup. & Environ. Hlth., Sch. Med., 3Dept. Hospital Pharmacy, Univ. Occup. & Environ. Hlth., 4Dept. Nutr. Sci., Univ. SJG.
Journal of Pharmacological Sciences 118 (suppl) 135-135, 2012.

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P1-1-8 Upregulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells

Noriaki Satoh1, Yumiko Toyohira2, Susumu Ueno3, Masato Tsutsui4, Nobuyuki Yanagihara2
1Bio-information Research Center, Univ. Occup. Environ. Health, 2Dept. Pharmacol., Sch. Med., Univ. Occup. Environ. Health, 3Dept. Occup. Toxicol., Inst. indust. Ecol. Sci., 4Dept. Pharmacol., Ryukyu Univ. Facul. Med.
Journal of Pharmacological Sciences 118 (suppl) 135-135, 2012.

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P1-2-1 Pathophysiological role of TRPM2 channel in microglial activation

Takahito Miyake, Hisashi Shirakawa, Ayaka Kusano, Shinya Sakimoto, Masakazu Konno, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 136-136, 2012.

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P1-2-2 Promotion of microglial Aβ phagocytosis through the subtype-specific stimulation of nicotinic acetylcholine receptor

Kazuyuki Takata1, Shun Shimohama2, Yoshihisa Kitamura1
1Dept. Neurobiol., Kyoto Pharm. Univ., 2Dept. Neurol., Sapporo. Med. Univ., Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 136-136, 2012.

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P1-2-3 Dopamine attenuates LPS-induced expression of cytokine by inhibiting the nuclear translocation of NF-кB p65 in microglial cells.

Yuta Sugino, Yasuhiro Yoshioka, Kazuya Nishimoto, Takuma Nishizawa, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Dept. Pharmacotherap, Faculty Pharmaceut. Sci., Setsunan Univ
Journal of Pharmacological Sciences 118 (suppl) 136-136, 2012.

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P1-2-4 Sesamin suppresses thrombin-induced activation of microglia in rats

Yasuhiro Matsuoka, Masatoshi Ohnishi, Madoka Takahashi, Misato Motomura, Atsuko Inoue
Dept. Pharmacother., Fac. Phar., Pharmaceut. Sci. Fukuyama Univ.
Journal of Pharmacological Sciences 118 (suppl) 136-136, 2012.

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P1-2-5 Expression of transglutaminase 2 and factor XIII-A in microglial activation

Kenji Kawabe, Katsura Takano, Mitsuaki Moriyama, Yoichi Nakamura
Lab. Integrative Physiology, Vet. Sci., Osaka Pref. Univ
Journal of Pharmacological Sciences 118 (suppl) 137-137, 2012.

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P1-2-6 Gh/transglutaminase 2 enhances adenylylcyclase activity in glioma cells.

Yoshimi Yanagihata, Tomohiro Abe, Yutaro Obara, Norimichi Nakahata
Dept. Cell. Signal., Grad. Sch. Pharmaceut. Sci., Tohoku Univ.
Journal of Pharmacological Sciences 118 (suppl) 137-137, 2012.

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P1-2-7 Discovery of a Tamoxifen-related Compound that Suppresses Glial L-Glutamate Transport Activity without Interaction with Estrogen Receptors

Kaoru Sato1, Jun-ichi Kuriwaki1, Kanako Takahashi1, Yoshiro Saito2, Jun-Ichiro Oka2, Yuko Otani3, Yu Sha3, Ken Nakazawa1, Yuko Sekino1, Tomohiko Ohwada3
1Div. Pharmacol., NIHS, 2Lab. Pharmacol., Fucul. Pharmaceut. Sci., Tokyo Univ. Sci., 3Lab. Organic Medic. Chem., Grad. Sch. Pharmaceut. Sci., Univ.
Journal of Pharmacological Sciences 118 (suppl) 137-137, 2012.

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P1-2-8 TRP channels are involved in hypercapnic Ca responses in rat glia-rich medullary cultures independent of extracellular pH

Yutaka Hirata, Yoshitaka Oku
Div. of Physiome, Hyogo College of Med.
Journal of Pharmacological Sciences 118 (suppl) 137-137, 2012.

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P1-3-1 Comprehensive analysis of cerebral blood flow in awake mice

Yuji Takahara, Saori Okada, Norio Matsuki, Yuji Ikegaya
Lab. Chem, Pharmacol, Grad. Sch. Pharma Sci, Univ of Tokyo.
Journal of Pharmacological Sciences 118 (suppl) 138-138, 2012.

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P1-3-2 Spike frequency decoding of Cdc42 in cortical neurons revealed by novel fluorescent indicators based on forster resonance energy transfer

Yusaku Ohta, Syunsuke Kishi, Shigeyuki Namiki, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 138-138, 2012.

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P1-3-3 Nitric Oxide-Induced Calcium Release via Ryanodine Receptors

Toshiko Yamazawa1, Sho Kakizawa1, 2, Yili Chen3, Akihiro Ito3, Takashi Murayama4, Hideto Oyamada5, Nagomi Kurebayashi4, Osamu Sato4, Takashi Sakurai4, Katsuji Oguchi5, Hiroshi Takeshima2, Nobuhito Saito3, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., The Univ. Tokyo, 2Dept. Biol. Chem., Grad. Sch. Pharm. Sci., Kyoto Univ., 3Dept. Neurosurg., Grad. Met., The Univ. Tokyo, 4Dept. Pharmacol., Juntendo Univ. Sch. Med., 5Dept. Pharmacol., Showa Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 138-138, 2012.

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P1-3-4 Nitric oxide-mediated regulation of Ca2+/calmodulin-dependent protein kinases

Tsuyoshi Takata, Yukihiro Tsuchiya, Yasuo Watanabe
Dept. Pharmacol., Showa Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 138-138, 2012.

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P1-3-5 Ca2+/calmodulin-dependent protein kinase IV is regulated via redox reaction

Yukihiro Tsuchiya, Jun Kimura, Yasuo Watanabe
Dept. Pharmacol., Showa Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 139-139, 2012.

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P1-3-6 Sequential phosphorylation of Ca2+/calmodulin-dependent protein kinase Iβ2 in cortical neurons

Yasuhito Naito, Yoriko Kondo, Mitsuo Tanabe
Dept. Pharmacol., Sch. Pharmac. Sci., Kitasato Univ.
Journal of Pharmacological Sciences 118 (suppl) 139-139, 2012.

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P1-3-7 Cell surface expression of GHRHR is regulated by the interaction of GHRHR with PICK1

Takeya Sato, Moe Ito, Yuki Suzuki, Jun Sukegawa, Teruyuki Yanagisawa
Dept. Molpharm., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 139-139, 2012.

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P1-3-8 Analysis of consensus receptor binding sites of histamine H3 receptor interacting proteins

Masahiro Miyata, Sakura Hiraide, Shou Shiba, Erina Sasaki, Takeya Sato, Teruyuki Yanagisawa, Jun Sukegawa
Dept. Molec. Pharmacol., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 139-139, 2012.

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P1-4-1 Behavioral analysis of Girdin mutant mice

Tsuyoshi Nakai1, Taku Nagai1, Naoya Asai2, Atsushi Enomoto2, Masahide Takahashi2, Kiyofumi Yamada1
1Dept. Neuropsychophamacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 2Dept. Pathol., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 140-140, 2012.

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P1-4-2 NMDA receptors and protein synthesis are necessary for reinstatement of conditioned fear

Huilian Shen, Norio Matsuki, Hiroshi Nomura
Lab. of Chem. Pharmacol., Grad. Sch. Pharm., Univ. of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 140-140, 2012.

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P1-4-3 Effects of memantine, a NMDA receptor antagonist, on learning behavior and synaptic plasticity in juvenile diabetes mellitus rats.

Banri Segawa, Hiroaki Sacai, Sachie Hamada, Jun-Ichiro Oka
Lab. Pharmacol., Fac. Pharm. Sci., Tokyo Univ. Sci.
Journal of Pharmacological Sciences 118 (suppl) 140-140, 2012.

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P1-4-4 The rat infralimbic cortex controls impulsive behavior

Iku Kimura1, Yu Ohmura1, Takeshi Izumi1, Taku Yamaguchi2, Takayuki Yoshida1, Mitsuhiro Yoshioka1
1Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med., 2Dept. Pharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.
Journal of Pharmacological Sciences 118 (suppl) 140-140, 2012.

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P1-4-5 Characterizing therapeutic psychoactive drugs in terms of the effects on impulsivity

Yu Ohmura, Iku Tsutsui-Kimura, Haruko Kumamoto, Takeshi Izumi, Takayuki Yoshida, Mitsuhiro Yoshioka
Dept. Neuropharmacol., Hokkaido Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 141-141, 2012.

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P1-4-6 Involvement of serotonergic and glutamatergic mechanisms in the hippocampus underlying fear conditioning in early postnatal stressed rats

Sachiko Hiraide1, Machiko Matsumoto1, Yoshiki Yanagawa1, Yasuhiro Saito1, Sumitaka Inoue1, Mitsuhiro Yoshioka2, Hiroko Togashi1
1Dept. Phamacol., Fac. of Pham. Sci., Health Sci. Univ. of Hokkaido, 2Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 141-141, 2012.

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P1-4-7 Change of neuronal activity in lateral amygdala by fear conditioning correlates with freezing

Ayako Nonaka, Norio Matsuki, Hiroshi Nomura
Lab. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 141-141, 2012.

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P1-4-8 Glycine betaine ameliorates homocysteine-mediated memory impairment, but not its metabolite dimethylglycine

Natsuki Nakashima1, Saori Kinoshita1, Toshitaka Nabeshima1, Masayuki Hiramatsu1, 2
1Dept. Chem. Pharmacol., Fac. Pharmacy, Meijo Univ., 2Lab. Neuropsychopharmacol., Grad. Sch. Environ. Human Sci., Meijo Univ.
Journal of Pharmacological Sciences 118 (suppl) 141-141, 2012.

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P1-5-1 Dietary supplementation of nitrite improves swallowing dysfunction induced by permanent bilateral common carotid artery occlusion in rats

Hirokazu Matsuzaki1, Erika Toya1, Fumika Maruoka1, Yuko Hinami1, Naohiro Iwata2, Yasuhide Hibino2, Mari Okazaki1
1Pharmacol., Fac. Pharm. Sci., Josai Univ., 2Immunobiochem., Fac. Pharm. Sci., Josai Univ.
Journal of Pharmacological Sciences 118 (suppl) 142-142, 2012.

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P1-5-2 Gs-linked receptor GPR3 modulates neuronal survival under the hypoxic conditions

Shigeru Tanaka1, 2, 3, Tatsuhiro Miyagi1, Eisuke Dohi1, 2, Izumi Hide1, Takahiro Seki1, Yoshinaga Saeki3, E. Antonio Chiocca3, Masayasu Matsumoto2, Norio Sakai1
1Dept. Mol. & Phaemacal. Neurosci., Hiroshima Univ. Sch. Biomed. Sci., 2Dept. Clin. Neurosci. & Therap., Hiroshima Univ. Sch. Biomed. Sci., 3Dept. Neurol. Surg., Ohio State Univ.
Journal of Pharmacological Sciences 118 (suppl) 142-142, 2012.

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P1-5-3 Application of T-type calcium channel blockers to treatment of ischemic brain injury

Hiroyuki Nishikawa1, Sachi Matsuda1, Anna Fukatsu1, Yuko Kurokawa1, Maho Matsunami1, Shogo Tokuyama2, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm., 2Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobegakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 142-142, 2012.

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P1-5-4 Cilostazol rescues the BBB from AGE-related Ischemic insult

Tomonori Takeshita1, Rie Tatsumi2, Shinsuke Nakagawa2, 3, Nobutaka Horie1, Kentaro Hayashi1, Kazuhiko Suyama1, Kunihiko Tanaka2, Izumi Nagata1, Masami Niwa2, 3
1Depart. Neurosurgery, Nagasaki Univ. Sch. Med, 2Depart. Pharmacol., Nagasaki Univ. Sch. Med, 3BBB Laboratory, PharmaCo-Cell Company Ltd.
Journal of Pharmacological Sciences 118 (suppl) 142-142, 2012.

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P1-5-5 Effects of sodium nitrite on ischemia/reperfusion-induced cerebral injury in non-diabetic and diabetic rats

Naohiro Iwata1, Mari Okazaki2, Emiko Takamura1, Shinya Kamiuchi1, Hirokazu Matsuzaki2, Yasuhide Hibino1
1Immunobiochem., Fac. Pharm. Sci., Josai Univ., 2Pharmacol., Fac. Pharm. Sci., Josai Univ.
Journal of Pharmacological Sciences 118 (suppl) 143-143, 2012.

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P1-5-6 Protective action of mithramycin against neurodegeneration and impairment of long-term potentiation in the hippocampal CA1 area after transient global ischemia

Nobuhiro Osada, Yasuhiro Kosuge, Hiroko Miyagishi, Kumiko Ishige, Yoshihisa Ito
Lab., of Pharmacol., Sch., of Pharm., Nihon Univ.
Journal of Pharmacological Sciences 118 (suppl) 143-143, 2012.

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P1-5-7 Biguanide derivatives with pyrazine and benzene groups： new synthesized dual channel blockers with both potent NMDAR and ASIC1a inhibitory activities.

Takashi Masuko1, Muneharu Miyake2, Toyofumi Suzuki3, Kazuo Tomono3, Kuniko Kusama-Eguchi4, Yasuo Kizawa1, Tadashi Kusama1
1Lab. Physiol. and Anat., Nihon Univ. Sch. Pharm., 2Lab. Organ., Nihon Univ. Sch. Pharm., 3Lab. Pharmaceutics., Nihon Univ. Sch. Pharm., 4Lab. Biochem., Nihon Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 143-143, 2012.

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P1-6-1 Proteasome inhibitor induces apoptosis through the induction of NOX5 expression via transcriptional factor GATA2.

Akiko Yamamuro, Maya Nakagawa, Kensaku Hatanaka, Yasuhiro Yoshioka, Yuki Ishimaru, Sadaaki Maeda
Dept. Pharmacotherap., Fac. Pharmaceut. Sci., Setsunan Univ.
Journal of Pharmacological Sciences 118 (suppl) 143-143, 2012.

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P1-6-2 Sepsis induces histopathological changes in mouse brain： association with increased NADPH oxidase activity

Hiroki Yokoo, Seiji Yamamoto, Yuichi Hattori
Dept. Mol. Med. Pharmacol., Gradu. Sch. Med. Pharmaceu. Sci., Univ. Toyama
Journal of Pharmacological Sciences 118 (suppl) 144-144, 2012.

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P1-6-3 Methamphetamine-induced hyperthermia and dopaminergic neurotoxicity in rats： involvement of α1D-adrenergic receptor

Kazue Kikuchi-Utsumi1, Mami Ishizaka1, Nobuko Matsumura1, Masahiko Watabe1, Koji Aoyama1, Nobuyuki Sasakawa2, Toshio Nakaki1
1Dept. Pharmacol., Teikyo Univ. Sch. Med., 2Dept. Information and Communication Sci., Faculty of Sci. and Technolo., Sophia Univ.
Journal of Pharmacological Sciences 118 (suppl) 144-144, 2012.

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P1-6-4 Enhanced neurotoxicity in the Cl- pump 55 kDa subunit (CIP55)-null mice

Kaori Kitagawa, Chiyoko Inagaki, Tomoyuki Nakamura
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 144-144, 2012.

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P1-6-5 Nitric oxide-induced loss of orexin neurons in vivo accompanied by aggregate formation

Kanae Obukuro, Moeko Takigawa, Akinori Hisatsune, Youitiro Isohama, Hiroshi Katsuki
Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci. Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 144-144, 2012.

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P1-6-6 Antioxidative mechanism by S-nitrosylation of Keap1 in CNS

Yoshiki Koriyama1, 2, Kenzo Chiba2, Matsumi Yamazaki2, Satoru Kato1
1Dept. Mol. Neurobiol., Grad. Sch. Med., Kanazawa University, 2Dept. Biochem., Fuc. pharm. Sci., Hokuriku University
Journal of Pharmacological Sciences 118 (suppl) 145-145, 2012.

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P1-6-7 3, 3', 4', 5'-Tetrahydroxyflavone reduces soluble amyloid Aβ protein dimers

Hiroko Ushikubo1, Yui Tanimoto1, Tatsuhiro Akaishi1, Tomohiro Asakawa2, Toshiyuki Kan2, Kazuho Abe1
1Lab. Pharmacol., Fac. Pharm., Musashino Univ., 2Syn. Org. & Med. Chem., Sch. Pharmaceut. Sci., Univ. Shizuoka.
Journal of Pharmacological Sciences 118 (suppl) 145-145, 2012.

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P1-6-8 The role of heparin-binding epidermal growth factor like growth factor (HB-EGF) on light-induced retinal damage

Yuki Inoue, Tomohiro Nakanishi, Atsushi Oyagi, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 118 (suppl) 145-145, 2012.

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P1-6-9 Effects of edaravone-loaded liposome eyedrops on light-induced retinal degeneration in mice

Masamitsu Shimazawa1, Hiroki Shimazaki1, Kohei Hironaka2, Yuichi Tozuka2, Kazuhiro Tsuruma1, Hirofumi Takeuchi2, Hideaki Hara1
1Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ., 2Pharmaceut. Eng., Dept. Drug. Deliv. Tech. and Sci., Gifu Pharmaceut Univ.
Journal of Pharmacological Sciences 118 (suppl) 145-145, 2012.

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P1-7-1 Novel P2X4 antagonist NCP-308 reduces allodynia induced by scinatic nerve injury

Eriko Nakata1, 2, Toshiyasu Imai1, Toru Kawasaki1, Toru Ogawa1, Shogo Sakuma1, Tomio Yamakawa1, Kazuhide Inoue2
1Discovery Research Lab., Nippon Chemiphar Co.,Ltd., 2Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 146-146, 2012.

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P1-7-2 P2X4 receptor spinal microglia is involved in mechanical allodynia in experimental autoimmune neuritis rats.

Toru Ogawa1, Toshiyasu Imai1, Eriko Nakata1, Toru Kawasaki1, Toshitake Hirai1, Yuka Araki1, Tomio Yamakawa1, Kazuhide Inoue2
1Discovery Research Lab., Nippon Chemiphar Co.,Ltd., 2Dept. Mol. Sys. Phamacol., Grad. Sch. Pharmceut. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 146-146, 2012.

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P1-7-3 Effect of cilnidipine, an N- and L-type Ca2+ channel blocker, on mechanical hypersensitivity after peripheral nerve injury in mice

Yuma Suzuki, Shohei Yamamoto, Masahiro Ohsawa, Hideki Ono
Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 118 (suppl) 146-146, 2012.

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P1-7-4 Gabapentin prevents oxaliplatin-induced mechanical hyperalgesia in mice

Saki Otake1, Shohei Yamamoto1, Masahiro Ohsawa1, Masahide Noji2, Hideki Ono1
1Lab. CNS Pharmacol., Grad. Shc. Pharm. Sci., Nagoya City Univ, 2Kidani Memorial Trust Fund (KMT)
Journal of Pharmacological Sciences 118 (suppl) 146-146, 2012.

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P1-7-5 Inhibitory mechanism of pentazocine on norepinephrine transporter activity

Go Obara1, Hirohide Inagaki2, Yumiko Tohohira2, Susumu Ueno3, Takeyoshi Sata1, Nobuyuki Yanagihara2
1Dept. Anesthe., Univ. Occup. & Environ. Hlth., Japan, Sch. Med, 2Dept. Pharmacol., Univ. Occup. & Environ. Hlth., Japan, Sch Med, 3Dept. Occup. Toxicol., Inst. Indust. Ecol. Sci
Journal of Pharmacological Sciences 118 (suppl) 147-147, 2012.

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P1-7-6 Decreased expressions of microRNAs in the injured DRG neurons of neuropathic pain rats

Atsushi Sakai, Hidenori Suzuki
Dept. Pharmacol., Nippon Med. Sch.
Journal of Pharmacological Sciences 118 (suppl) 147-147, 2012.

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P1-7-7 Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system

Kazuo Nakamoto1, Takashi Nishinaka1, Kengo Matsumoto1, Mitsumasa Mankura2, Yutaka Koyama3, Shogo Tokuyama1
1Dept. Clinic. Pharm., Sch., Pharmaceu. Sci., Kobe Gakuin Univ., 2Ikeda Tohka Ind. Co., 3Lab. Pharmacol. Facul. Pharma. Osaka Ohtani Univ.
Journal of Pharmacological Sciences 118 (suppl) 147-147, 2012.

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P1-7-8 Weight bearing test is useful for evaluation of on-going pain induced by bone cancer in mice

Tomomi Shirai1, Hiroshi Yamashita1, Rikiya Ichise1, Miyuki Takashima1, Hiroyuki Takamatsu1, Kazuo Umemura2
1Hamamatsu Pharma Reseach, Inc., 2Dept. Pharmcol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 147-147, 2012.

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P1-8-1 Clock gene Per1 in spinal astrocytes regulates the expression of inflammtory factors

Tatsuhiko Sugimoto, Norimitsu Morioka, Koichi Sato, Kazue Hisaoka, Yoshihiro Nakata
Dept. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 148-148, 2012.

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P1-8-2 Ca2+-dependent translational control of N-cadherin in astrocytes underlies neuroprotection upon brain injury

Kazunori Kanemaru1, Jun Kubota1, Kenzo Hirose2, Yohei Okubo1, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo, 2Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 148-148, 2012.

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P1-8-3 The collagen-binding protein of Streptococcus mutans is involved in hemorrhage.

Kazuya Hokamura1, Koichiro Wada2, Kazuhiko Nakano3, Min Thura4, Takashi Ooshima3, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2Dept. Pharmacol., Grad. Sch. Dent. Osaka Univ., Osaka University, 3Dept. Pediatric Dent., Grad. Sch. Dent. Osaka Univ., Osaka University, 4Med. Photonics Res. Cent., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 148-148, 2012.

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P1-8-4 Role of endogenous tissue-type plasminogen activator in behavioural disorder after stroke.

Yasuhiro Suzuki1, Malgorzata Zajda1, 2, Nobuo Nagai3, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med., 2Dept. Neurol. Warsaw Univ. Sch. Med., 3Dept. Animal Biosci. Nagahama Inst. Bio-Sci. Tech.
Journal of Pharmacological Sciences 118 (suppl) 148-148, 2012.

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P1-8-5 Tracking the Leakage of Albumin in BBB-disrupted ischemia

Keyue Iiu1, Jiyong Zhang1, Hidenori Wake1, Kiyoshi Teshigawara1, Hideo Takahashi2, Shuji Mori3, Masahiro Nishibori1
1Dept. Pharmacol., Okayama Univ. Sch. Med, 2Dep. of pharmacology kinki Univ. Sch. Med, 3Shuijitsu Univ.
Journal of Pharmacological Sciences 118 (suppl) 149-149, 2012.

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P1-8-6 Role of neutrophilic mPGES-1 in stroke injury

Yuri Ikeda-Matsuo1, Yuri Hirayama2, Satoshi Uematsu3, Shizuo Akira3, Mitsuo Tanabe1, Yasuharu Sasaki1
1Lab. Pharmacol., Sch. Pharmac. Sci., Kitasato Univ., 2Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi, 3Lab. Host Defense, Immunol Front Res Center, Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 149-149, 2012.

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P1-8-7 Activation of astrocytes is involved in ischemic tolerance in MCAO-model mice

Yuri Hirayama1, Yuri Ikeda-Matsuo2, Schuichi Koizumi1
1Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi, 2Dept. Pharmacol., Sch. Pharm. Sci, Univ. Kitasato
Journal of Pharmacological Sciences 118 (suppl) 149-149, 2012.

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P1-9-1 Anticonvulsant effects of AEDs against PTZ-induced generalized seizures are controlled by NO levels in mice brain.

Masatomo Watanabe1, Asuka Miyai1, 2, Kouichi Itoh1
1Lab of Mol & Cell Neurosci, Kagawa Sch of Pharmaceutical Sci, Tokushima Bunri Univ, 2Dept of Pharmacy, National Hospital Organization Kochi National Hospital.
Journal of Pharmacological Sciences 118 (suppl) 149-149, 2012.

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P1-9-2 cAMP induces morphological plasticity of neurons in the epileptic brain.

Soichiro Nakahara1, Kenji Tanaka2, Junichi Nabekura2, Mineo Iseki3, Masakatsu Watanabe4, Norio Matsuki1, Ryuta Koyama1
1Laboratory of Chemical Pharmacology, Graduate School Pharmaceutical Sciences, 2Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 3Faculty of Pharmaceutical Sciences, Toho University, 4The Graduate School for the Creation of New Photonics Industries
Journal of Pharmacological Sciences 118 (suppl) 150-150, 2012.

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P1-9-3 Pathophysiological alterations of synaptic vesicle protein 2A (SV2A) in Groggy rat, a rat model of absence seizure.

Takahiro Okumura1, Shizuka Ishihara1, Ryo Terada1, Chisato Tomita1, Ryosuke Kitaya1, Kentarou Tokudome1, Tomoya Tanaka1, Saki Shimizu1, Yoshiko Kawai1, Tadao Serikawa2, Masashi Sasa3, Yukihiro Ohno1
1Lab. Pharmacol., Osaka Univ Pharm. Sci., 2Inst. Lab. Animals, Grad. Sch. Med., Kyoto Univ., 3Nagisa Hospital
Journal of Pharmacological Sciences 118 (suppl) 150-150, 2012.

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P1-9-4 Electroconvulsive Seizure Reverses Neuronal Maturation in the Dentate Gyrus of Hippocampus

Yuki Imoto1, Katsunori Kobayashi2, 3, Eri Segi-Nishida4
1Dept. Physiol Chem., Kyoto Univ. Pharm. Sci., 2Dept. Pharmacol., Nippon Med. Sch., 3JST, CREST, 4Dept. Syst. Biosci. for Drug Discov., Kyoto Univ. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 150-150, 2012.

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P1-9-5 Further study on the mechanism of a novel antidepressant-like action of tipepidine in rats - involvement of dopamine D1 and adrenaline α2 receptors

Kei Hayasaki, Keiko Hamao, Kazuaki Kawaura, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Environ. Mol. Health Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 150-150, 2012.

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P1-9-6 Influence of Hochuekkito on the MRI responce in the brain of human and of depression model rat： The difference by the drug sensitivity

Michihisa Tohda1, Masami Kanzaki1, Yukihisa Murakami2, Akihiro Kobayashi3, Takashi Yokawa4
1Inst. of Natl. Med., Univ. of Toyama, 2Cent. for Int. Med. Res., School of Med., Keio Univ., 3Kobe BMA.Lab., BioView Inc., 4BioView Inc.
Journal of Pharmacological Sciences 118 (suppl) 151-151, 2012.

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P1-9-7 Effect of Yokukansan on decrease in voluntary activity with dexamethasone administering mice

Daichi Nagashima1, Rin Okabe1, Kazuki Terada1, Nobuaki Kasai1, Syota Mochiduki1, Toru Iizuka2, Nobuo Izumo1
1Dept. Clin. Pharmacol., Yokohama Coll. Pharm., 2Dept. Kampo Pharm., Yokohama Coll. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 151-151, 2012.

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P1-9-8 H3 receptor blockade increases locomotor activity in sleep-deprived wild type and H1 receptor knockout mice

Attayeb Mohsen, Fumito Naganuma, Katsuhiko Shibuya, Tadaho Nakamura, Takeo Yoshikawa, Nobuyuki Okamura, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ. Grad, Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 151-151, 2012.

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P1-10-1 Motor control by the cerebellar dopamine D3 receptors in rats.

Ayaka Tatara, Maho Sato, Tomone Sugiuchi, Satoshi Miyoshi, Saki Andatsu, Tomoya Kizu, Saki Shimizu, Yoshiko Kawai, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 151-151, 2012.

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P1-10-2 S100A4 is a causative factor for disruption of the blood-brain barrier in collagen-induced arthritic mice

Tsuyoshi Nishioku, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharm. Care. Health Sci., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 152-152, 2012.

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P1-10-3 RGMa enhances T cell activation in autoimmune encephalomyelitis

Rieko Muramatsu1, 2, Takekazu Kubo1, 2, Yuka Nakamura1, 2, Yuki Fujita1, 2, Toshihide Yamashita1, 2
1Dept. Mol. Neurosci., Grad. Sch. of Med., Osaka Univ., 2JST-CREST
Journal of Pharmacological Sciences 118 (suppl) 152-152, 2012.

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P1-10-4 S-nitrosylation of cyclooxygenase in the hypothalamic paraventricular nucleus spinally projecting neurons is involved in bombesin-induced activation of central adrenomedullary outflow in rats

Kenjiro Tanaka, Takahiro Shimizu, Kumiko Nakamura, Kunihiko Yokotani
Dept. Pharmacol., Sch. of Medicine, Kochi Univ.
Journal of Pharmacological Sciences 118 (suppl) 152-152, 2012.

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P1-10-5 Interaction between glioblastoma cells and primary rat brain endothelial cells in in vitro blood-brain barrier model.

Keisuke Toyoda1, Kunihiko Tanaka2, Tomonori Takeshita1, Kenta Ujifuku1, Kensaku Kamada1, Kentaro Hayashi1, Takayuki Matsuo1, Izumi Nagata1, Masami Niwa2
1Dept. Neurosurgery., Nagasaki Univ. Sch. Med, 2Dept. Pharmacol., Nagasaki Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 152-152, 2012.

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P1-10-6 Hypothermic effects of oseltamivir phosphate (Tamiflu) in mice： relation to peripheral sympathetic nervous system function

Yui Iwajima1, Yuko Nagano1, Shohei Yamamoto1, Yasuhiro Maeda2, Masahiro Ohsawa1, Hideki Ono1
1Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Lab. Hosp. Pharmacy. Grad. Sch. Pharm. Sci., Nagoya City Univ.
Journal of Pharmacological Sciences 118 (suppl) 153-153, 2012.

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P1-10-7 Preventive effects of solmack on alcohol hangover-like model in mice

Yoshiyuki Hayashida1, Seiichi Katayama1, Hiroshi Atai1, Katsuhide Nishi1, Yasuhiko Nishioka2, Tsukasa Kirimoto2
1Pharmacology Efficacy Research Group, Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Corporation, 2Healthcare research and development part, Laboratory, TAIHO PHARMACEUTICAL CO.,LTD.
Journal of Pharmacological Sciences 118 (suppl) 153-153, 2012.

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P1-10-8 Isobolographic analysis of indazole and phenytoin.

Nobuko Matsumura, Kazue Kikuchi-Utsumi, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 153-153, 2012.

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P1-11-1 Dissecting the roles of CNOT3 in cardiac development and functions

Takashi Suzuki1, Mizuho Nakayama1, Teruki Sato1, Masayuki Morita1, Akihiko Ichikawa1, Tadashi Yamamoto2, Yumiko Imai1, Keiji Kuba1
1Biol. Inf. and Ex. Ther., Akita Univ. Sch. Med., 2Divi. Oncol. Tokyo Univ. Insti. Med. Sci.
Journal of Pharmacological Sciences 118 (suppl) 153-153, 2012.

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P1-11-2 Expression of sarcomeric-related proteins in the period of heart-beat initiation in early rat embryo

Sachiko Maeda, Takeshi Kobayashi, Noritsugu Tohse
Dept. Cellular Physiol. and Signal Transduction, Sapporo Med. Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 154-154, 2012.

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P1-11-3 Species differences between Microminipigs and dogs on drug-induced long QT syndrome.

Kiyotaka Hoshiai, Yukitoshi Nagayama, Hiroyuki Saitou, Yasuki Akie, Akemi Saitou
Dept. Pharmacol., Cmic Bio. Res.
Journal of Pharmacological Sciences 118 (suppl) 154-154, 2012.

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P1-11-4 In vivo cardiac imaging system of zebrafish using a fluorescent dye for the assessment of anticancer drug-induced cardiotoxicity

Saki Ito1, Noriko Umemoto1, Kana Okamori1, Yuhei Nishimura1, 2, 3, 4, Miko Kawabata1, 5, Zi Zhang1, Beibei Zhang1, Junya Kuroyanagi1, Yasuhito Shimada1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Mol. and Cell. Pharmacol., Pharmacol., Pharmacogeno. and Pharmacoinfor., Mie Univ. Grad. Sch. Med, 2Mie Univ. Med. Zebra. Res. Cent., 3Dept. Bioinfo. Mie Univ. Life Sci. Res. Cent., 4Dept. Omics Med., Mie Univ. Indu. Tech. Innov. Inst., 5Dept. Clin. Anesthe. Mie Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 154-154, 2012.

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P1-11-5 Analysis of anticancer drug induced cardiotoxicity using a transgenic zebrafish line

Kana Okamori1, Noriko Umemoto1, Saki Ito1, Yuhei Nishimura1, 2, 3, 4, Miko Kawabata1, 5, Zi Zhang1, Beibei Zhang1, Junya Kuroyanagi1, Yasuhito Shimada1, 2, 3, 4, Toshio Tanaka1, 2, 3, 4
1Dept. Mol. and Cell. Pharmacol., Pharmacogeno. and Pharmacoinfor., Mie Univ. Grad. Sch. Med, 2Mie Univ. Med. Zebra. Res.Cent., 3Dept. Bioinfo. Mie Univ. Life Sci. Res. Cent., 4Dept. Omics Med., Mie Univ., Indu. Tech. Innov.Inst., 5Dept. Clin. Anesthe. Mie Univ. Sch.
Journal of Pharmacological Sciences 118 (suppl) 154-154, 2012.

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P1-11-6 PAR1-mediated myofibroblast transformation and Smad phosphorylation in rat cadiac fibroblasts

Hitomi Otani, Chihiro Ueda, Tomoyuki Nakamura
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 155-155, 2012.

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P1-11-7 The effect of nicorandil on Na+/Ca2+ exchange (NCX) current in heart

Jiazhang Wei1, Kazuhiko Takeuchi1, Kanna Yamashita2, Tomomi Yamakawa1, 2, Satomi Kita3, Takahiro Iwamoto3, Hiroshi Watanabe1, Junko Kimura4, Yasuhide Watanabe2
1Dept Clin Pharmacol & Ther. Hamamatsu Univ. Sch. Med., 2Dept. Health Sci, Hamamatsu Univ. Sch. Med., 3Dept. Pharmacol., Faculty Med., Fukuoka Univ., 4Dept. Pharmacol., Fukushima Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 155-155, 2012.

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P1-11-8 Nicorandil, Mitochondrial ATP-Sensitive Potassium Channel Opener, Protects Cardiomyocytes against alpha-B-Crystallin R120G-Induced Apoptosis

Atsushi Sanbe, Erika Koizumi, Yu Tezuka, Hideo Nishigori
Dept. Pharmacotherapeutics, Iwate Med. Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 155-155, 2012.

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P1-11-9 Effect of Nicorandil on the production of interstitial adenosine via NO and/or ATP sensitive potassium ion channels in rat hearts

Toshio Obata
Department of Analytical Chemistry, Ohu University, School of Pharmaceutical Sciences
Journal of Pharmacological Sciences 118 (suppl) 155-155, 2012.

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P1-12-1 L-type Ca2+ channel (LTCC) activity and the response to β-AR stimulation are negatively regulated by Ca2+ induced Ca2+-release (CICR) in cardiac myocytes.

Hiroko Izumi-Nakaseko, Atsushi Sugiyama, Satomi Adachi-Akahane
Dept. Pharmacol., Fac. Med., Toho Univ.
Journal of Pharmacological Sciences 118 (suppl) 156-156, 2012.

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P1-12-2 An involvement of sympathetic nervous system stimulation in a gender disparity of nongenomic actions of dihydrotestosterone on cardiac L-type Ca2+ currents

Fernando Lopez-Redondo, Junko Kurokawa, Tetsushi Furukawa
Dept. Bioinformational Pharmacol., MRI, Tokyo Med. Dent. Univ.
Journal of Pharmacological Sciences 118 (suppl) 156-156, 2012.

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P1-12-3 Effect of terfenadine and pentamidine on the hERG channel current and its intracellular trafficking： Automated voltage clamp and confocal microscopic analyzes

Takayuki Oka, Atsushi Ohtsuki, Yukiko Takahashi, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Pharmaceutical Sciences
Journal of Pharmacological Sciences 118 (suppl) 156-156, 2012.

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P1-12-4 in silico analysis of hERG channel facilitators

Yuko Yamakawa1, Kazuharu Furutani2, Atsushi Inanobe2, Yoshihisa Kurachi2
1Dept. Mathmatical Human Health., Osaka Univ. Sch. Med., 2Dept. Pharmacol., Osaka Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 156-156, 2012.

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P1-12-5 Sphingolipids Modulate Kir Channel Functions

Kazuharu Furutani1, 2, Yoshihisa Kurachi1, 2
1Dept. Pharmacol., Grad. Sch. Med., Osaka Univ., 2MEI center, Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 157-157, 2012.

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P1-12-6 A novel in vivo rabbit model simultaneously assessing electrophysiological properties of atrium and ventricle

Fumiya Yoneyama, Mihoko Hagiwara, Toshiki Chiba, Akira Takahara
Dept. Pharmacol. Ther., Faculty of Pharm. Sci., Toho Univ.
Journal of Pharmacological Sciences 118 (suppl) 157-157, 2012.

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P1-12-7 Potassium current density and electrical activity of guinea-pig pulmonary vein myocardium

Yayoi Tsuneoka, Yuka Kobayashi, Takahiko Sugimoto, Akira Takahara, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 157-157, 2012.

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P1-12-8 Involvement of fatty acid in the regulation of cardiac pacemaker activity

Hiroko Maruyama, Hiroko Izumi-Nakaseko, Masanori Ito, Atsushi Sugiyama, Satomi Adachi-Akahane
Dept. Pharmacol., Fac. Med., Toho Univ.
Journal of Pharmacological Sciences 118 (suppl) 157-157, 2012.

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P1-12-9 Development and evaluation of cell protocol for automated patch clamp technique

Atsushi Ohtsuki1, 2, Takayuki Oka1, Iyuki Namekata1, Hikaru Tanaka1
1Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci., 2Nanion Technologies GmbH
Journal of Pharmacological Sciences 118 (suppl) 158-158, 2012.

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P1-13-1 Pharmacological profile of YM-244769, a specific NCX inhibitor, in cardiac myocytes

Satomi Kita1, Yasuhide Watanabe2, Kanna Yamashita2, Toshiki Yamada1, Tomomi Yamakawa2, Shintaro Yamamoto1, Junko Kimura3, Takahiro Iwamoto1
1Dept. Pharmacol., Facul. Med., Fukuoka Univ., 2Dept. Health Sci., Hamamatsu Univ. Sch. Med., 3Dept. Pharmacol., Fukushima Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 158-158, 2012.

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P1-13-2 Eplerenone suppresses ventricular arrhythmias, in associated with connexin43, KCNE1/KCNQ1 and SERCA2a mediation.

Kazuki Noda, Miyuki Kobara, Tomohisa Imayama, Moeko Saito, Michiru Tsuji, Koki Yamada, Jiahong Wang, Hiroe Toba, Tetsuo Nakata
Dept. Pharmacol., Kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 158-158, 2012.

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P1-13-3 Evaluation of the antifibrillatory drug interactions between amiodarone and lidocaine in perfused rabbit hearts

Abdulrahman A. Almotrefi, Mohammad S. Alhumayyd
Department of Pharmacology, King Saud University
Journal of Pharmacological Sciences 118 (suppl) 158-158, 2012.

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P1-13-4 Effect ofβ-estradiol-dependent relaxation in type 2 diabetic mice aortas

Akitaka Morishige, Kumiko Taguchi, Takayuki Matsumoto, Katsuo Kamata, Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 118 (suppl) 159-159, 2012.

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P1-13-5 Mechanisms underlying the impairment of EDHF-type relaxation in superior mesenteric artery from hyperinsulinemic diabetic rats

Kaori Kuroda, Takayuki Matsumoto, Kumiko Taguchi, Katsuo Kamata, Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ.
Journal of Pharmacological Sciences 118 (suppl) 159-159, 2012.

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P1-13-6 Protective effects of tempol on abnormal coronary vasodilation of SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP. ZF) with metabolic syndrome

Satomi Kagota1, Yukari Tada1, Kazuhito Fukushima2, Keiji Umetani3, Kana Maruyama1, Hirokazu Wakuda1, Masaru Kunitomo4, Kazuki Nakamura4, Kazumasa Shinozuka1
1Dept. Pharmacol. II Sch. Pharmaceu. Sci., Mukogawa Women's Univ., 2Dept. Radio. Nuc. Med., NCCC, 3JASRI (SPring8), 4Dept. Pharmacol. I, Sch. Pharmaceu. Sci., Mukogawa Women's Univ.
Journal of Pharmacological Sciences 118 (suppl) 159-159, 2012.

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P1-13-7 Protease-activated receptor-2 (PAR2) mediated vasodilation in SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF) with metabolic syndrome

Kana Maruyama1, Satomi Kagota1, Hirokazu Wakuda1, John J. McGuire2, Kazuki Nakamura3, Masaru Kunitomo3, Kazumasa Shinozuka1
1Dept. Pharmacol. II, Mukogawa Women's Univ. Sch. Pharm. Pharmaceuti. Sci., 2Cardiovasc. Res., Div. Biomed. Sci., Memorial Univ., 3Dept. Pharmacol. I, Mukogawa Women's Univ. Sch. Pharm. Pharmaceuti. Sci.
Journal of Pharmacological Sciences 118 (suppl) 159-159, 2012.

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P1-13-8 Effect of apelin siRNA on the maturation of blood vessels

Yuki Ishimaru1, Nao Matsumoto1, Kosuke Higashino1, Akihide Sumino1, Atsushi Kasai1, 2, Yasuhiro Yoshioka1, Akiko Yamamuro1, Sadaaki Maeda1
1Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ., 2Dept. Psychiatry, Semel Institute for Neuroscience and Human Behavior, UCLA
Journal of Pharmacological Sciences 118 (suppl) 160-160, 2012.

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P1-13-9 Dysfunction of endothelial nitric oxide synthase produced by increasing vascular dihydrobiopterin in rats

Katsuhiko Noguchi1, Toshihiro Matsuzaki1, Mayuko Sakanashi1, Naobumi Hamadate1, Junko Nakasone1, Kumiko Arakaki2, Matao Sakanashi1, Masato Tsutsui1
1Dept. Pharmacol., Grad. Sch. Med., Univ. Ryukyus, 2Dept. Cardiovasc. Med., Nephrol., Neurol., Grad. Sch. Med., Univ. Ryukyus
Journal of Pharmacological Sciences 118 (suppl) 160-160, 2012.

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P1-14-1 DIURETICS-INDUCED HYPERURICEMIA： THE INTERACTION ON RENAL PROXIMAL TUBULE ORGANIC ANION EFFLUX TRANSPORTER NPT4/SLC17A3

Promsuk Jutabha1, Hiroyuki Kusuhara2, Yuichi Sugiyama2, Hitoshi Endou3, Naohiko Anzai1
1Dept. Pharmacol. Toxicol., Dokkyo Medical Univ. Sch. Med., 2University of Tokyo, Graduate School of Pharmaceutical Sciences, 3J-pharma Co.Ltd
Journal of Pharmacological Sciences 118 (suppl) 160-160, 2012.

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P1-14-2 AN ANGIOTENSIN RECEPTOR BLOCKER, LOSARTAN IS TRANSPORTED BY HUMAN VOLTAGE-DRIVEN ORGANIC ANION TRANSPORTER NPT4

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P1-14-3 Amelioration of cisplatin-induced mouse renal lesions by a cyclooxygenase (COX)-2 selective inhibitor

Naho Takahashi, Shigeyoshi Honma, Makoto Yoshida
Dept. Pathophysiol., Fac. Pharmacy, Takasaki University of Health and welfare
Journal of Pharmacological Sciences 118 (suppl) 161-161, 2012.

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P1-14-4 Induction of renal metallothionein and reduction of cisplatin-induced renal toxicity by a herbal preparation, cepharanthin

Norio Sogawa1, Chiharu Sogawa1, Kanji Hirai1, 2, Kazumi Ohyama3, Ge rile1, Xue-fang Wen1, Ayako Jinzenji1, 2, Takuya Miyawaki2, Shigeo Kitayama1
1Dept. Dent. Pharmacol. Okayama Univ. Grad. Sch. Med. Dent. & Pharmaceut. Sci., 2Dept. Dent. Anesthesiol. & Special Care Dent. Okayama Univ. Grad. Sch. Med. Dent. & Pharmaceut. Sci., 3RI Res. Cent. Okayama Univ. Dent. Sch.
Journal of Pharmacological Sciences 118 (suppl) 161-161, 2012.

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P1-14-5 Preventive effect of GGsTop(TM), a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemic acute kidney injury in rats

Ryosuke Tanaka1, Shinya Yamamoto1, Bunta Watanabe2, Jun Hiratake2, Mamoru Ohkita1, Yasuo Matsumura1
1Lab. Pathol. and Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci., 2Institute for Chemical Research, Kyoto University
Journal of Pharmacological Sciences 118 (suppl) 161-161, 2012.

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P1-14-6 Pitavastatin attenuates hyperglycemia-induced podocyte injury by bone morphogenetic protein-7 preservation

Aika Kan1, Miyuki Kobara1, Ryou Yoshikawa1, Akihiro Sebe1, Kyoko Matsuo1, Kazuki Noda1, Jiahong Wang1, Hiroe Toba1, Takehiko Wada2, Tetsuo Nakata1
1Dept. Clinical Pharmacol., Kyoto Pharmaceutical Univ., 2Dept. Nephrology, Tokyo Univ. Med
Journal of Pharmacological Sciences 118 (suppl) 161-161, 2012.

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P1-14-7 Aggregated protein causes glomerular disorders in diabetic mice

Yasushi Hirasawa1, 2, Yukari Matsui2, Yukiko Kawasaki2, Takahiro Sugiura2, Tadashi Nagamatsu1
1Department of Pharmacology, Faculty of Pharmacy, Meijo University., 2Nihon Bioresearch Inc.
Journal of Pharmacological Sciences 118 (suppl) 162-162, 2012.

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P1-15-1 A New Model of Gastric Bleeding in Rats by Co-Administration of Aspirin Plus Clopidogrel

Shinichi Takayama, Chitose Izuhara, Misaki Itayama, Naoto Houshin, Yusuke Okamoto, Koji Takeuchi
Div. of Path. Sci., Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 162-162, 2012.

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P1-15-2 Roles of COX/PGE2, NOS/NO, and Enterobacteria in Pathogenesis of Ischemic Enteritis in Rats

Toshiko Murakami, Tohru Kotani, Yoshino Komatsu, Manami Takahashi, Manabu Ifuku, Koji Takeuchi
Div. of Path. Sci., Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 162-162, 2012.

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P1-15-3 Serotype k Streptococcus mutans strains with collagen-binding properties aggravates inflammatory bowel diseases

Ayuchi Kojima1, 2, Koichiro Wada1, Kazuhiko Nakano2, Takashi Ooshima2, Kazuo Umemura3, Atsushi Nakajima4, Yoshinori Kamisaki1
1Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ., 2Dept. Pediatric Dent., Grad. Sch. Dent., Osaka Univ., 3Dept. Pharmacol. Hamamatsu Univ., 4Gastroenterol. Div., Yokohama City Univ. Hospital.
Journal of Pharmacological Sciences 118 (suppl) 162-162, 2012.

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P1-15-4 Depression and sensitization of tension responses in TNBS-inflammatory rat colon

Hiromi Nobe, Yukisato Ishida, Yashusi Sakai
Dept. Health Sci. Tech., Bunkyo gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 163-163, 2012.

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P1-15-5 Gap junction-dependent regulation of intestinal motility by secretory phospholipase A2

Ryoya Nomura1, Hiromichi Fujino1, Shunji Horie2, Toshihiko Murayama1
1Lab. Chemical Pharmacol., Grad Sch. Pharm. Sci. Chiba Univ., 2Lab. Pharmacol., Fac. Pharm. Sci., Josai International Univ.
Journal of Pharmacological Sciences 118 (suppl) 163-163, 2012.

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P1-15-6 Neural M1 muscarinic receptor mediates inhibition of mouse colonic motility through activation of nitrergic nerves

Takaji Kondo1, Hiroki Teraoka1, Toshihiro Unno2, Sei-ichi Komori2, Masahisa Yamada3, Takio Kitazawa1
1Dept. Pharmacol., Sch. of Vet. Med., Rakuno Gakuen University, 2Lab. Pharmacol. Fac. Applied Biol. Sci. Gifu University, 3Okinawa Institute of Science and Technology
Journal of Pharmacological Sciences 118 (suppl) 163-163, 2012.

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P1-15-7 Effects of CJ-33466, a 5-HT4 Receptor Partial Agonist, on Visceral Hypersensitivity and Gastric Motility in Rats

Katsuyo Ohashi-Doi1, 2, Katsuomi Ichikawa1, 3, Yoichi Kurebayashi1, 2
1Integrated Drug Dis. Sci., Grad. Sch. Med., Kobe Univ., 2Dis. Res., Pfizer Nagoya Laboratories, Pfizer Inc, 3Clin Pharm., Clin Res, Development Japan, Pfizer Inc
Journal of Pharmacological Sciences 118 (suppl) 163-163, 2012.

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P1-15-8 The Effects of a 5-HT3 Receptor Antagonist, Alosetron, on Inflammation- and Stress-induced Visceral Hypersensitivity in the Rat

Katsuyo Ohashi-Doi1, Nobuyuki Takahashi2, Yutaka Makizaki3, Tohru Komada3
1Intergrated Drug Dis. Sci., Kobe Univ. Sch. Med., 2Dis. Res. RaQualia Pharma Inc., Discovery Research, RaQualia Pharma Inc., 3Dis. Service, Charles River Lab., Discovery Service, Charles River Laboratories Japan
Journal of Pharmacological Sciences 118 (suppl) 164-164, 2012.

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P1-16-1 Fisetinl prevents osteoclastogenesis via impairment of NFATc1 expression and blocking of Erk phosphorylation

Megumi Sugawara1, Eiko Sakai2, Kazuhisa Nishishita2, Yutaka Fukuma2, Kuniaki Okamoto2, Noriaki Yoshida1, Takayuki Tsukuba2
1Div. Orthodont. and Biomed. Engineer., Dept. Develop. Reconst. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2Div. Oral Pathopharmacol. Dept. Develop. Reconst. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 164-164, 2012.

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P1-16-2 Effects of quercetin on osteoclastogenesis and involvement in membrane estrogen receptor GPR30

Masaaki Masuhara, Tomoaki Sato
Dept. Appl. Pharmacol., Grad. Sch. Med. Dent. Sci. Kagoshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 164-164, 2012.

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P1-16-3 Effect of bisphosphonates on osteoclasts and their precursor cells

Keigo Abe1, Yoshitaka Yoshimura2, Yoshiaki Deyama2, Yoshimasa Kitagawa1, Kuniaki Suzuki2
1Dept. Oral Diag. and Oral Med., Grad. Sch. of Dent. Med., Hokkaido Univ., 2Dept. Mol. Cell Pharmacol., Grad. Sch. of Dent. Med. Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 164-164, 2012.

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P1-16-4 Effect of estrogen on OVX rats by femoral neck strength test

Sho Hirano1, Yukiko Ishibashi2, Kazuki Terada1, Sachiko Kikuchi1, Yuki Mizutani1, Takahiro Tsuchiya1, Shinya Yamada1, Nobuo Izumo1
1Dept. Clin. Pharmacol., Yokohama Coll. Pharm., 2Dept. Synth. Org. Chem., Yokohama Coll. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 165-165, 2012.

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P1-16-5 Effects of risedronate and menatetrenone (vitamin K2) on bone strength properties in rat treated with cyclosporine A

Junkichi Kanda1, Taketoshi Shimakura2, Atsushi Takahashi3, Noriaki Yamamoto2, Kenji Onodera4, Hiroyuki Wakabayashi1
1Dept. Clin. Pharmacother., Niigata Univ. Pharm. Appli. Life. Sci., 2Niigata Bone Sci. Inst., 3Clin. Dent. for Disabled, Tohoku Univ. Hosp., 4Lab. Pharmacother. Yokohama Col. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 165-165, 2012.

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P1-16-6 Post-injured changes of the properties of mesenchymal stem cells derived from the human anterior cruciate ligament

Shuya Nohmi1, 2, Yuji Yamamoto2, Yasusuki Ishibashi2, Eiichi Tsuda2, Hiroki Mizukami3, Soroku Yagihashi3, Satoshi Toh2, Shigeru Motomura1, Ken-Ichi Furukawa1
1Dept. Pharmacol., Hirosaki Univ. Sch. Med., 2Dept. Orthop., Hirosaki Univ. Sch. Med., 3Dep. Pathol. Mol., Hirosaki Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 165-165, 2012.

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P1-16-7 Identification and localization of mesenchymal stem cells derived from human spinal ligaments

Shunfu Chin1, 2, Toru Asari1, Ken-Ichi Furukawa2, Yoshifumi Harada1, Atsushi Ono1, Kanichiro Wada1, Toshihiro Tanaka1, Wataru Inaba3, Hiroki Mizukami3, Shigeru Motomura2, Soroku Yagihashi3, Satoshi Toh1
1Dept. Orthop., Hirosaki Univ. Gradu. Sch, Med., 2Dept. Pharmaco., Hirosaki Univ. Gradu. Sch. Med., 3Dept. Patho. Mole. Med, Hirosaki Univ. Gradu. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 165-165, 2012.

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P1-16-8 The Effects of Combination of Chondroitinase and Hyperbaric Oxygen Preconditioning on Spinal Cord Injuried Rats

Yong-Xin Sun1, Yu-Yan Fan2, Hong-Peng Li3
1the Department of Rehabilitation in the First Hospital of China Medical University, 2BeiKing TongRen Hospital, 3the First Hospital of China Medical University
Journal of Pharmacological Sciences 118 (suppl) 166-166, 2012.

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P1-17-1 Physiological function of nuclear DGKα under serum depleted conditions

Yuko Kiso1, Yasuhito Shirai2, Megumi Sakuma1, Momo Ikeda1, Naoaki Saito1
1Lab. of. Mol. Pharmacol., Biosignal. Res. Ctr., Kobe Univ, 2Grad. Sch. of Agricultural Sci., Kobe Univ.
Journal of Pharmacological Sciences 118 (suppl) 166-166, 2012.

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P1-17-2 The molecular mechanism involving in lysophosphatidic acid-induced colony dispersal in A431 cells

Shoichi Ochiai1, Daisuke Furuta2, Kazuya Sugita1, Norihisa Fujita1, 2
1Grad. Sch. Sci. and Eng., Ritsumeikan Univ., 2Dept Pharmacol. Sch Pharmacy, Ritsumeikan Unv.
Journal of Pharmacological Sciences 118 (suppl) 166-166, 2012.

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P1-17-3 A novel regulatory mechanism of tyrosine hydroxylase gene expression via a new actin cytoskeleton formation enhancer (V-1)/DLK1/notch 1-mediated signaling in murine adrenal chromaffin cells

Yanxin Lai1, Jingmei Jin1, Ichiro Kawahata1, Junichi Morita1, Kohji Fukunaga1, 2, Hiroshi Ichinose3, Tohru Yamakuni1
1Dept of Pharmacother, Grad Sch of Pharmaceutical Sci, Tohoku Univ., 2Dept of pharmacol, Grad Sch of Pharmaceutical Sci, Tohoku Univ, 3Dept of Life Sci, Grad Sch of Biosci and Biotech, Tokyo Instit of Tech
Journal of Pharmacological Sciences 118 (suppl) 166-166, 2012.

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P1-17-4 Functional analysis of Nse3/Nse4 complex related to a neurodevelopmental disease

Naoya Tanabe, Hideo Taniura
Lab. Neurochem., Dept. Pharmacy, Ritsumeikan Univ.
Journal of Pharmacological Sciences 118 (suppl) 167-167, 2012.

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P1-17-5 Effect of nicotinic acetylcholine receptor desensitization on nicotine- induced phosphorylation of ERK in PC12h cells.

Hitoshi Nakayama, Jing Zhao, Masanori Yoshizumi
Dept. Pharmacol., Nara Med. Univ. School. Med
Journal of Pharmacological Sciences 118 (suppl) 167-167, 2012.

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P1-17-6 Effect of Src on estrogen-induced proliferation of breast cancer stem cells

Naoya Hirata, Yuko Sekino, Yasunari Kanda
Div. Pharmacol., Natl. Inst. Hlth. Sci.
Journal of Pharmacological Sciences 118 (suppl) 167-167, 2012.

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P1-17-7 Stimulatory effect of ATP on insulin secretion by mouse pancreatic islets via P2X receptors

Masahiro Ohtani, Kiyoshi Ohura
Department of Pharmacology, Osaka Dental University
Journal of Pharmacological Sciences 118 (suppl) 167-167, 2012.

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P1-17-8 Immediate activation of P-glycoprotein by SB203580： Does the p38-MAPK pathway directly affect P-glycoprotein?

Hirokazu Wakuda1, 3, Shino Miyauchi1, Kana Maruyama1, Satomi Kagota1, Kazuki Nakamura1, Keizo Umegaki2, Shizuo Yamada3, Kazumasa Shinozuka1
1Dept. Pharmacol., Sch. Pharmaceu. Sci., Mukogawa Women's Univ., 2Natl. Inst. Health Nutrition, 3Dept. of Pharmacokinet. and Pharmacodyn., Sch. Pharm. Sci., Univ. Shizuoka
Journal of Pharmacological Sciences 118 (suppl) 168-168, 2012.

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P1-18-1 Enhancement of Ca2+ responses and salivary secretion in vivo expression of Stim1 in rat submandibular acinar cells

Takao Morita1, Akihiro Nezu1, Yosuke Tojyo2, Akihiko Tanimura1
1Dept. Pharmacol., Sch. Dentistry, Health Sciences Univ. of Hokkaido, 2Dept. Integrated Human Sciences, Sch. Dentistry, Health Sciences Univ. of Hokkaido
Journal of Pharmacological Sciences 118 (suppl) 168-168, 2012.

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P1-18-2 Delivery of the cytosolic IP3-biosensor and monitoring of intracellular IP3 responses in rat salivary acinar cells

Akihiro Nezu1, Takao Morita1, Yosuke Tojyo2, Akihiko Tanimura1
1Dept. Pharmacol., Sch. Dent., Health Sci. Univ. Hokkaido, 2Dept. Integrated Human Sci., Sch. Dent., Health Sci. Univ. Hokkaido
Journal of Pharmacological Sciences 118 (suppl) 168-168, 2012.

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P1-18-3 TARGETING DEGRADATION PATHWAYS OF RGS2 USING HIGH-THROUGHPUT RNAI SCREENING

Benita Sjogren1, Steven Swaney2, Richard R. Neubig1, 2
1Dept. of Pharmacology, University of Michigan, 2Center for Chemical Genomics, University of Michigan
Journal of Pharmacological Sciences 118 (suppl) 168-168, 2012.

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P1-18-4 Potent inhibitory effects of RGS2, RGS3 and EGS8 on intracellular calcium responses induced by vasoactive peptides

Dan Song, Mariko Nishiyama, Sadao Kimura
Dept. Biochem. & Mol. Pharmacol., Grad. Sch. Med., Chiba Univ.
Journal of Pharmacological Sciences 118 (suppl) 169-169, 2012.

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P1-18-5 Possible dephosphorylation of GABAB receptor by dual-specificity phosphatases.

Machiko Ito, Hiroki Niihara, Natsuki Tanaka, Ken-ichi Yamada, Miho Washida, Yukari Saito, Kiyokazu Ogita, Nobuyuki Kuramoto
Dept. of Pharmacol., Setsunan Univ.
Journal of Pharmacological Sciences 118 (suppl) 169-169, 2012.

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P1-18-6 β1-adrenergic receptor is recycling via recycling endosomes, upon the ligand stimulation

Takatoshi Nakagawa, Michio Asahi
Dept. Pharmacol., Fac. Med., Osaka Medical College
Journal of Pharmacological Sciences 118 (suppl) 169-169, 2012.

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P1-18-7 Anticholinergic agents excreted in the urine bind to muscarinic receptor in the rat bladder urothelium

Yusuke Fuchihata, Masaki Ogoda, Shizuo Yamada
Dept. of Pharmacokinet. and Pharmacodyn., Sch. Pharm. Sci., Univ. Shizuoka
Journal of Pharmacological Sciences 118 (suppl) 169-169, 2012.

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P1-18-8 Characterization of specific ［3H］ imidafenacin binding sites in rat tissues

Shiori Kuraoka, Xuan Huo, Yoshihiko Ito, Shizuo Yamada
Dept. of Pharmacokinet. and Pharmacodyn., Sch. Pharm. Sci., Univ. Shizuoka
Journal of Pharmacological Sciences 118 (suppl) 170-170, 2012.

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P1-19-1 Accelerating effect of acyclic retinoid NIK-333 on the restoration of liver mass and recovery of liver function in 70% partially hepatectomized rats

Mitsutoshi Kimura1, Hajime Moteki1, Makiko Watanabe2, Naoto Ishibashi2, Shingo Yanagida2, Masahiko Ogihara1
1Dept. Clinical Pharmacol., Fac. Pharmaceut. Sci., Josai Univ., 2Tokyo New Drug Res. Lab., Pharmaceut. Div., Kowa Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 170-170, 2012.

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P1-19-2 CLCA isoforms and structural proteins differentially expressed in a reconstruction model derived from rat skin

Jun Yamazaki1, Kazuhiko Okamura2, Hiroshi Murakami3, Shozaburo Hata4, Ryo Hiromatsu3, Ayako Miyazaki4, Tsuyako Ohkubo1, Mitsutoki Hatta1
1Dept. Physiol. Sci. Mol. Biol., Fukuoka Dent. Coll., 2Dept. Morphol. Biol., Fukuoka Dent. Coll., 3Dept. Odontol., Fukuoka Dent. Coll., 4Dept. Oral Growth Develop., Fukuoka Dent. Coll.
Journal of Pharmacological Sciences 118 (suppl) 170-170, 2012.

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P1-19-3 Transformation from fibroblast to myofibroblast is regulated by TGFβ and mechanical tension in a rat skin reconstruction model

Shozaburo Hata1, Kazuhiko Okamura2, Hiroyuki Ishikawa1, Jun Yamazaki3
1Dept. Oral Growth Develop., Fukuoka Dent. Coll., 2Dept. Morphol. Biol., Fukuoka Dent. Coll., 3Dept. Physiol. Sci. Mol. Biol., Fukuoka Dent.Coll.
Journal of Pharmacological Sciences 118 (suppl) 170-170, 2012.

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P1-19-4 Induced pluripotent stem cells generated from a mouse model of Sandhoff disease

Makoto Tanaka1, Yasuhiro Ogawa1, Toshihiro Suzuki2, Tadayasu Togawa2, Hitoshi Sakuraba2, Kazuhiko Oishi1
1Dept. Pharmacol., Meiji Pharmaceutical Univ., 2Dept. Anal. Biochem., Meiji Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 171-171, 2012.

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P1-19-5 Effects of Angiotensin II on differentiation of mouse induced pluripotent stem cells into cardiovascular progenitor cells

Haduki Goshima, Toshiaki Ishizuka, Ayako Ozawa, Yasuhiro Watanabe
Dept. Pharmacol. Natl. Def Med. Col.
Journal of Pharmacological Sciences 118 (suppl) 171-171, 2012.

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P1-19-6 Involvement of PI3K/Akt and MEK/MAPK pathways on proliferation enhanced by angiotensin II type 1 receptor stimulation in human induced pluripotent stem cells

Ayako Ozawa, Toshiaki Ishizuka, Haduki Goshima, Yasuhiro Watanabe
Dept. Pharmacol. Natl. Def. Med. Col.
Journal of Pharmacological Sciences 118 (suppl) 171-171, 2012.

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P1-19-7 Modes of action of genes facilitating ischemia-induced VEGF secretion in human mesenchymal stem cells

Tomomi Kuramochi1, 2, Mitsutoshi Satoh1, Haruka Atsuki1, 2, Satoshi Yasuda2, Takao Hayakawa3, Kazuhiro Suzuki2, Yoji Satoh2
1Dept. of Toxicol. & Pharmacol., Phar. Sci., Toho Univ., 2Div. of Cell. & Gene Thpy. Prod., NIHS., 3Phar. Res. & Tech. Inst., Kinki Univ.
Journal of Pharmacological Sciences 118 (suppl) 171-171, 2012.

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P1-19-8 Role of adrenergic receptors in the neural differentiation from pluripotent stem cells

Yukari Suda1, Naoko Kuzumaki1, 2, Michiko Narita1, Atsumi Nagasawa1, Yusuke Hamada1, Yohei Okada2, JamesHirotaka Okano2, 3, Hideyuki Okano2, Minoru Narita1
1Dept. Pharamcol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Dept. Physiol., Keio Univ. Sch. Med., 3Division of Regenerative Medicine, Jikei University School of Medicine
Journal of Pharmacological Sciences 118 (suppl) 172-172, 2012.

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P1-20-1 Functional analysis of cedar pollen allergy using cultured mast cells

Hiroki Koike, Mizuki Imagawa, Marin Hato, Kazutaka Maeyama
Dept. Pharmacol. Informational Biomedicine, Ehime Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 172-172, 2012.

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P1-20-2 Effects of statins on histamine synthesis and histamine release in rat basophilic leukemia (RBL-2H3) cells

Muhammad N. A. Sahid, Shuang Liu, Kazutaka Maeyama
Dept. Pharmacol. Informational Biomedicine, Ehime Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 172-172, 2012.

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P1-20-3 Analysis of enlarged granules in beige rats (as a model for Chediak-Higashi syndrome)： morphological and functional studies of mast cells.

Takeshi Kiyoi1, 2, Kazutaka Maeyama1
1Dept. Pharmacol, Informational Biomedicine, Ehime Univ. Grad. Sch. Med., 2Integrated Center for Science, Ehime Univ
Journal of Pharmacological Sciences 118 (suppl) 172-172, 2012.

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P1-20-4 Effect of cholesterol depletion on sphingolipids metabolism and degranulation in RBL2H3 mast cells

Tomohiko Makiyama, Hiroyuki Nakamura, Toshihiko Murayama
Laboratory of chemical pharmacology, Graduate School of Pharmaceutical Sciences Chiba University
Journal of Pharmacological Sciences 118 (suppl) 173-173, 2012.

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P1-20-5 Purinergic receptors modulate degranulation in LAD2 cells

Haruhisa Nishi
Dept. Pharmacol., Jikei Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 173-173, 2012.

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P1-20-6 Involvement of Rac in histamine H4 receptor-mediated chemotaxis of mast cells

Atsuo Kuramasu1, Mie Wakabayashi2, Makoto Inui1, Kazuhiko Yanai2
1Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med., 2Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 173-173, 2012.

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P1-20-7 M1 and M5 muscarinic acetylcholine receptor-mediated leukocyte migration

Kosuke Harada, Yuji Matsumoto, Kazuo Umemura
Dept. Pharmacol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 173-173, 2012.

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P1-20-8 Identification of cyclooxygenase-2 expressing cells in draining lymph nodes of a pleurisy model.

Michiko Kawamura1, Yoshihito Tada2, Ko Hatanaka1, Yoshiteru Harada2
1Dept. Pharmacol., Kitasato Univ. Sch. Med., 2Dept. of Mediator and Signal Transduction Pharmacol.
Journal of Pharmacological Sciences 118 (suppl) 174-174, 2012.

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P1-20-9 Identification of prostaglandin E2 synthesis pathway in exosomes derived from mouse macrophages.

Akinobu Yoshino, Hiroki Naraba, Tomoko Sakyo, Takayuki Kitagawa
Dept. Cell Biol. and Mol. Pathol. Sch. Pharm., Iwate Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 174-174, 2012.

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P1-21-1 JNK signaling promotes intestinal tumorigenesis through mTOR complex 1 activation in Apc△716 mice

Teruaki Fujishita1, Masahiro Aoki2, Makoto Taketo1
1Dpt. Pharmcol. Kyoto Univ. Grad. Sch. Med., 2Div. Mol. Pathol. Aichi Cencer Center Res. Inst.
Journal of Pharmacological Sciences 118 (suppl) 174-174, 2012.

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P1-21-2 Differentiation-inducing factor-1 suppressed the expression of c-Myc in human colon cancer cell line, HCT-116

Kentaro Jingushi, Fumi Takahashi, Toshihisa Nakamura, Toshiyuki Sasaguri
Dept. Clinical. Pharmacol., Fac. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 174-174, 2012.

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P1-21-3 The analysis of telomeric status in “Extraordinary Cancer Resistant Mammal” Naked mole rat.

Yoshihiro Tsuchiya1, Shingo Miyawaki2, Natsuki Arai2, Minoru Narita1, Hideyuki Okano2, Kyoko Miura2
1Dept. Pharmacol., Sch. Pharm. Pharmaceut. Sci. Hoshi Univ., 2Dept. of Physiology, School of Med. Keio Univ.
Journal of Pharmacological Sciences 118 (suppl) 175-175, 2012.

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P1-21-4 Development of novel SRPK inhibitors based on the Structural Analysis

Yukiko Okuno1, Mitsuteru Hoshina2, Hiroshi Onogi3, Yosuke Nonaka3, Keiko Tsuchihashi3, Takamitsu Hosoya4, Teikichi Ikura2, Nobutoshi Ito2, Masatoshi Hagiwara1
1Dept. of Anatomy and Develop Biol., Grad. School of Medicine, Kyoto Univ., 2Labratory of Structural Biology, Graduate School of Biomedical Science, Tokyo Medical and Dental University, 3Kino Pharma , Inc., 4Laboratory of Chemical Biology, Graduate School of Biomedical Science, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University
Journal of Pharmacological Sciences 118 (suppl) 175-175, 2012.

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P1-21-5 Estimation of the relationship between the structure and tumor-specificity of 1, 2, 3, 4-tetrahydroisoquinoline derivatives by molecular-orbital methods

Yoshihiro Uesawa1, Kiminori Mohri1, Masami Kawase2, Mariko Ishihara3, Hiroshi Sakagami4
1Clinical Pharmaceutics Laboratory, Meiji Pharm. Univ., 2Fac. Pharm. Sci., Matsuyama Univ., 3Div. Basic Chem., Meikai Univ. Sch. Dent., 4Div. Pharmacol., Meikai Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 175-175, 2012.

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P1-21-6 CNT1 and RRM1 are involved in resistance mechanism of the gemcitabine resistant pancreatic cancer cells

Tatsuhiko Furukawa1, Kentaro Minami1, 2, Yukihiko Nishizawa1, 2, Ryuji Ikeda2, Masatatsu Yamamoto1, Yasuo Takeda2
1Dept. Mol. Onc, Grad Sch. Medical and Dental Sciences, Kagoshima Univ, 2Dept. Clinical Pharmacy and Pharmacology, Grad Sch. Medical and Dental Sciences, Kagoshima Univ
Journal of Pharmacological Sciences 118 (suppl) 175-175, 2012.

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P1-21-7 Potential involvement of NADE in rat hepatic cancer

Yoko Amagase1, Kanako Morita1, Maho Ikenaga1, Arisu Yamamoto1, Atsushi Ono2, Hiroshi Yamada3, Yasuo Ohno4
1Dept. Pathophys., Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, 2Div. Risk Assessment, NIHS, 3Toxicogenomics Informatics Project, Natl. Inst. Biomed. Innov., 4NIHS
Journal of Pharmacological Sciences 118 (suppl) 176-176, 2012.

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P1-21-8 Inhibition of CaMKII reduces oxaliplatin-induced mechanical allodynia in rats

Soichiro Uchio1, Nobuaki Egashira1, 2, Masafumi Shirahama3, Shota Yamamoto3, Ken Masuguchi3, Hikaru Sada1, Takehiro Kawashiri2, Ryozo Oishi1, 2
1Grad. Sch. Pharm. Sci., Kyushu Univ., 2Dept. Pharmacy, Kyushu Univ. Hosp., 3Fac. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 176-176, 2012.

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P1-21-9 Effects of minocycline on paclitaxel-induced painful peripheral neuropathy in mice

Kenji Honda, Yuichi Ushijima, Shouko Himeno, Mao Yamanouchi, Yuko Mori, Yuri Matsuda, Ryo Saito, Yukio Takano
Dept. Physiol and Pharmacol., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 176-176, 2012.

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P1-21-10 The aim at the reduction of the adverse effect of the antihormone therapies for the prostate cancer and breast cancer

Yutaka Matsuoka, Natsumi Kogure, Yui Kawasaki
Lab. Medicinal Sci., Fac. Pharm. Sci., Tokyo Univ. Sci.
Journal of Pharmacological Sciences 118 (suppl) 176-176, 2012.

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P1-22-1 Effects of Diisopropylamine dichloroacetate and calcium gluconate on anti-fatigue potential.

Daijiro Sugiyama, Yasutaka Iizuka, Norio Kokatsu, Yoshikazu Yamamoto, Masaaki Hanawa, Eiichi Mafune
Daiichi Sankyo Healthcare Co.,LTD.
Journal of Pharmacological Sciences 118 (suppl) 177-177, 2012.

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P1-22-2 Effect of psychological stress on platelet aggregation in mice

Fumikaze Matsuhisa1, 2, Eiki Satoh1
1Res. Cent. Animal Hyg. Food Saf., Obihiro Univ. Agric. Vet. Med., 2Dept. Basic Vet. Sci., Unit. Grad. Scho. Vet. Sci., Gifu Univ.
Journal of Pharmacological Sciences 118 (suppl) 177-177, 2012.

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P1-22-3 Proteomic analysis of psychological stress responses in the lung and spleen using histamine transporter deficient mice

Masahito Ogasawara1, Mieko Otani2, Emiko Kasahara3, Kohei Yamauchi4, Kazutaka Maeyama1
1Dept. Pharmacol, Ehime Univ. Sch. Med., 2Dept. Mol. Bio. Kobegakuinn Univ. Sch. Parmacy, 3Dept of Biochem. Osaka city Univ. Sch. Med, 4Dept of Med. Iwate Med Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 177-177, 2012.

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P1-22-4 Inhibitory effect of Jak2 inhibitor AG490 on H2O2-induced Ca2+ entry via TRPM2 channels

Hitomi Takashima1, 2, Masakazu Ishii1, Kazunori Akimoto1, Yasuo Mori2, Shunichi Shimizu1
1Dept. Pathophysiol., Showa Univ. Sch. Pharm., 2Dept. Synth. and Biol. Chem., Grad. Sch. Engineer., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 177-177, 2012.

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P1-22-5 Circadian regulation of neuroprotective role for glutathione in dopaminergic neuron

Chisato Kinoshita, Nobuko Matsumura, Kazue Kikuchi-Utsumi, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 178-178, 2012.

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P1-22-6 Possible involvement of astrocytes in spinal circadian rhythm

Tatsuhiko Sugimoto, Norimitsu Morioka, Masato Tokuhara, Kazue Hisaoka, Yoshihiro Nakata
Dept. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 178-178, 2012.

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P1-22-7 Regulatory mechanism of body temperature in the central nervous system during the arousal from hibernation in Syrian hamsters： Involvement of orexin

Yutaka Tamura1, 2, Mayuko Monden1, Masaya Odani1, Hirohito Shiomi1
1Dept. of Pharmacology. Fac. of Pharmacy & Pharmaceutical Sci., Fukuyama Univ., 2Green Sci. Res. Center, Fukuyama Univ.
Journal of Pharmacological Sciences 118 (suppl) 178-178, 2012.

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P2-1-1 Seamless pipeline for developing fluorescence imaging probes

Kenji Takikawa, Shigeyuki Namiki, Hirokazu Sakamoto, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med. Univ. Tokyo
Journal of Pharmacological Sciences 118 (suppl) 178-178, 2012.

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P2-1-2 Postsynaptic inositol 1, 4, 5-trisphosphate signaling maintains presynaptic function in the somatosensory cortex.

Jun Kubota, Yohei Okubo, Masamitsu Iino
Dept. Pharmacol., Sch. Med., Univ. Tokyo.
Journal of Pharmacological Sciences 118 (suppl) 179-179, 2012.

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P2-1-3 Functional activation of Gαq coupled with serotonin receptors in cerebral cortical membranes determined by antibody-capture scintillation proximity assay/［35S] GTPγS binding

Yuji Odagaki1, 2, Ryoichi Toyoshima1
1Dept. Psychiatry, Saitama Med. Univ., 2Moro Hosp.
Journal of Pharmacological Sciences 118 (suppl) 179-179, 2012.

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P2-1-4 The interaction of the cannabinoidergic and serotonergic system modulating synaptic transmission in the basal amygdala

Takayuki Yoshida1, Takeshi Izumi1, Yu Ohmura1, Masahiko Watanabe2, Mitsuhiro Yoshioka1
1Dept Neuropharmacol., Hokkaido Univ. Grad. Sch. Med., 2Dept Anat., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 179-179, 2012.

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P2-1-5 Differential source of calcium in potentiated spontaneous transmitter release in basolateral amygdala neurons

Yuki Miura
Lab. Chem Pharmacol., Grad Sch. Pharm Sci., Univ. Tokyo.
Journal of Pharmacological Sciences 118 (suppl) 179-179, 2012.

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P2-1-6 Target-cell dependent synaptic modulation of inhibitory synapses by nitric oxide in rat insular cortex

Kiyofumi Yamamoto, Noriaki Koshikawa, Masayuki Kobayashi
Dept. Pharmacol., Nihon Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 180-180, 2012.

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P2-1-7 Effects of D/C mosaic botulinum neurotoxin on the regulation of exocytosis in single adrenal chromaffin cells.

Mitsunori Hayashi1, Yuto Shibata1, Keiji Nakamura2, Shunji Kozaki2, Nobuyuki Sasakawa1
1Info. and Commu. Sci., Sci. and Tech., Sophia Univ., 2Div. Veter. Sci., Life and Env. Sci., Osaka Pref Univ.
Journal of Pharmacological Sciences 118 (suppl) 180-180, 2012.

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P2-1-8 Blockade of fasting-induced feeding augmentation by injection of Y1 and Y5 siRNAs into hypothalamic dorsomedial nuclei (DMN)

Tomohiro Shiiya, Hiroshi Higuchi
Div. Pharmacol., Mol. Cell. Med., Niigata Univ., Grad. Sch. Med. Den. Sci.
Journal of Pharmacological Sciences 118 (suppl) 180-180, 2012.

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P2-2-1 Difference of the electrophysiological characteristics between glutamatergic and GABAergic neurons in the amygdala

Takeshi Izumi, Takayuki Yoshida, Hiroki Shikanai, Yu Ohmura, Mitsuhiro Yoshioka
Dept. Neuropharmacol., Hokkaido Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 180-180, 2012.

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P2-2-2 Rabies virus tools for probing circuit structure and function

Fumitaka Osakada, Edward M. Callaway
Systems Neurobiology Lab, Salk Inst
Journal of Pharmacological Sciences 118 (suppl) 181-181, 2012.

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P2-2-3 EP4 receptor stimulation accelerated the neurite outgrowth

Hiroyoshi Tsuchiya1, Yukihiko Sugimoto3, Yoko Fujiwara1, Akio Fujimura2, Taka-aki Koshimizu1
1Dept. Mol. Pharamacol., Jichi. Med. Univ., 2Dept. Clin. Pharamacol., Jichi. Med. Univ., 3Dep. Pharm. Biochem., Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 181-181, 2012.

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P2-2-4 The distribution and subcellular localization of Gs-linked receptor GPR3 in rodent brain

Tatsuhiro Miyagi, Shigeru Tanaka, Izumi Hide, Takahiro Seki, Norio Sakai
Dept. Pharmacol. Neurosci., Grad. Sch. Biomed. Sci., Hiroshima Univ
Journal of Pharmacological Sciences 118 (suppl) 181-181, 2012.

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P2-2-5 Effect of endogenous sialidase on neurite outgrowth in human neuroblstoma cells

Shuhei Takahashi, Akinori Hisatsune, Youitirou Isohama, Hiroshi Katsuki
Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci. Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 181-181, 2012.

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P2-2-6 Signaling pathway of SUN13837, a novel compound mimicking the pharmacological actions of bFGF

Yoshiari Shimmyo, Taisuke Kadoshima, Mariko Kuroda, Ryoko Ogino, Toyofumi Masuda, Norihito Murayama, Shinya Ueno, Teruyoshi Inoue
Asubio Pharma
Journal of Pharmacological Sciences 118 (suppl) 182-182, 2012.

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P2-2-7 The interaction of CRMP1 and the actin binding domain of Filamin-A mediates Sema3A signaling.

Fumio Nakamura, Tomonobu Hida, Yoshio Goshima
Dept. Mol. Pharmacol. Yokohama City Univ. Grad Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 182-182, 2012.

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P2-2-8 Molecular mechanisms for the neurite outgrowth through the prostaglandin E2/cyclic AMP pathway in mouse dorsal root ganglion cells

Takashi Maeda, Kenji Mitani, Ryosuke Yamagata, Fumiko Sekiguchi, Atsufumi Kawabata
Div. Pharmacol. pathophysiol., Kinki Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 182-182, 2012.

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P2-3-1 P2Y6 purinoceptor mediates the constitutive pinocytosis in astrocytes

Yosuke Morizawa1, Kaoru Nasu-Tada2, Hidetoshi Saitoh3, Kazuhide Inoue3, Schuichi Koizumi1
1Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi, 2Div Pharmacol, Natl Inst Hlth Sci, 3Dept. Mol. Sys. Pharmacol., 2Grad. Sch. Pharmceut. Sci. Kyusyu Univ
Journal of Pharmacological Sciences 118 (suppl) 182-182, 2012.

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P2-3-2 Participation of TrkA signaling on anti-proliferative activity of brefelamide in 1321N1 human astrocytoma cells

Takahiro Shibuya1, Haruhisa Kikuchi2, Yoshiteru Oshima2, Shigeyoshi Honma1, Makoto Yoshida1
1Dept. Pathophysiol., Fac. Pharmacy, Takasaki University of Health and welfare, 2Dept. Natural Products Chemistry, Grad. Sch. Pharm. Sci. Tohoku University
Journal of Pharmacological Sciences 118 (suppl) 183-183, 2012.

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P2-3-3 Increases in astrocytic Kir4.1 channel expression by antiepileptic treatments.

Yuki Nagao, Takahiro Mukai, Aoi Okuda, Megumi Fujimoto, Asuka Ono, Yoshihisa Sakagami, Yuya Harada, Saki Shimizu, Yoshiko Kawai, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 183-183, 2012.

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P2-3-4 Regulation of glutamate transport by runt related transcription factor-2 in astrocytes

Takeshi Takarada, Koichi Fujikawa, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ.
Journal of Pharmacological Sciences 118 (suppl) 183-183, 2012.

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P2-3-5 Involvement of TRPC channels in sphingosine-1-phosphate-induced astrocytic responses

Shota Iida, Hisashi Shirakawa, Masakazu Konno, Keiko Kageyama, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci. Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 183-183, 2012.

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P2-3-6 Role of astrocyte in the hypothalamus on the high-fat diets preference in mice

Mai Katsuki1, Sei Higuchi1, Ryuji Yamaguchi1, Maiko Araki1, Makiko Ohji1, Riyo Furuta1, Kohei Kimoto1, Yuya Sakamoto1, Keiichi Irie1, Kiyoshi Matsuyama2, Kenji Mishima2, Shyutaro Katsurabayashi1, Kotaro Takasaki1, Kaori Kubota1, Kenichi Mishima1, Katsunori Iwasaki1, Michihiro Fujiwara1
1Dept. Neuropharmacology., Fukuoka Univ. Sch. Pharm. Sci, 2Dept. Chemical Engineering, Fukuoka Univ. Sch. Engineering
Journal of Pharmacological Sciences 118 (suppl) 184-184, 2012.

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P2-3-7 Influence of switching from high-fat to standard diet for high-fat diet preference in mice

Ryuji Yamaguchi1, sei Higuchi1, Mai Katuki1, Makiko Ohji1, Maiko Araki1, Kohe Kimoto1, Keiichi Irie1, Yuya Sakamoto1, Kiyosi Matuyama2, Kenji Misima2, Shutaro Katurabayashi1, Kotaro Takasaki1, Kaori Kubota1, Kenichi Mishima1, Katunori Iwasaki1, Michihiro Fujiwara1
1Dept. Neuropharmacol., Fac. Pharmac. Sci., Fukuoka Univ., 2Dept. Chemical Engineering. Fukuoka Univ. Sch. Engineering.
Journal of Pharmacological Sciences 118 (suppl) 184-184, 2012.

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P2-3-8 Methylmercury-evoked release of ATP from microglia increases IL-6 production from astrocytes via P2Y1 receptor activation

Youichi Shinozaki, Yusuke Noguchi, Yoshio Imura, Yosuke Morisawa, Yuri Hirayama, Ryohei Komatsu, Keisuke Shibata, Kayoko Fujishita, Schuichi Koizumi
Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ.
Journal of Pharmacological Sciences 118 (suppl) 184-184, 2012.

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P2-4-1 Effects of resveratrol on cocaine-induced dopamine D1 receptor signaling in the Striatum

Takahide Shuto, Mahomi Kuroiwa, Yuki Koga, Akinori Nishi
Dept. Pharmacol., Kurume Univ. Sch, Med.
Journal of Pharmacological Sciences 118 (suppl) 184-184, 2012.

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P2-4-2 In vivo glutamate imaging during spontaneous activities in the cerebral cortex

Hiroshi Sekiya1, Shigeyuki Namiki2, Hirokazu Sakamoto2, Kenzo Hirose2, Masamitsu Iino1
1Dept. Pharmacol., Univ. Tokyo Grad. Sch. Med., 2Dept. Neurobiol., Univ. Tokyo Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 185-185, 2012.

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P2-4-3 Comprehensive behavioral analysis of TRPM2-deficient mice

Emina Hashimoto1, Hisashi Shirakawa1, Minoru Sakakiyama1, Keizo Takao2, 3, Tsuyoshi Miyakawa2, 3, Takayuki Nakagawa1, Shuji Kaneko1
1Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ., 2Div. Sys. Med. Sci., ICMS, Fujita Health Univ., 3Sec. Beh. Patterns, NIPS
Journal of Pharmacological Sciences 118 (suppl) 185-185, 2012.

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P2-4-4 Hippocampal spatial learning and memory and synaptic plasticity at the Schaffer collateral-CA1 synapse in post-weaning mice fed exclusively milk

Toshiaki Ishii, Hideaki Nishie, Yoshikage Muroi
Dept. Basic Vet. Med., Obihiro Univ. Agri. and Vet. Med.
Journal of Pharmacological Sciences 118 (suppl) 185-185, 2012.

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P2-4-5 Cognitive impairments in intraventricularly streptozotocin-injected rats.

Shozo Kito1, Akiko Shingo2, Toshio Murase2
1Doai-kai Ozawa Hosp., Int. Med., 2Okinaka Memorial Inst for Med Res.
Journal of Pharmacological Sciences 118 (suppl) 185-185, 2012.

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P2-4-6 The hippocampus in intraventricularly streptozotocin-injected rats - immunohistochemical studies.

Akiko Shingo1, Toshio Murase1, Shozo Kito2
1Okinaka Memorial Inst for Med Res, 2Doai-kai Ozawa Hosp., Int. Med.
Journal of Pharmacological Sciences 118 (suppl) 186-186, 2012.

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P2-4-7 Involvement of microRNA-134 in the working memory-enhancing effect of nicotinic acetylcholine receptor agonist

Takashi Kubota, Toshiaki Masaki, Yutaka Kirino
Lab. Neurobiophysics, Kagawa Sch. Pharm. Sci. Tokushima Bunri Univ.
Journal of Pharmacological Sciences 118 (suppl) 186-186, 2012.

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P2-4-8 Chotosan ameliorates type 2 diabetes-induces cognitive deficits via improvement of central cholinergic and VEGF/PDGF systems in mice

Kinzo Matsumoto1, Qi Zhao1, Koichi Tsuneyama2, Ken Tanaka1, Feng Li1, Takeshi Miyata1, 3
1Inst. of Natural Med, Univ. Toyama, 2Grad. Sch. Med, Pharm. Sci., Univ. Toyama, 3Facult. Pharm. Sci., Sojo Univ.
Journal of Pharmacological Sciences 118 (suppl) 186-186, 2012.

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P2-4-9 Effects of perinatal exposure to bisphenol A on the function of central nervous system in male rat offsprings

Rika Kuwahara1, Shinichiro Kawaguchi1, Yumi Kohara2, Takashi Motokui1, Haiming Cui2, Kimihiro Yamashita1, 2
1Grad. Sch. Sci. Technol., Nagasaki Univ., 2Grad. Sch. Fish. Sci. Env. Stu., Nagasaki Univ.
Journal of Pharmacological Sciences 118 (suppl) 186-186, 2012.

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P2-5-1 Protective effects of the β3-adrenoceptor agonist CL316243 against N-methyl-D-aspartate-induced retinal neurotoxicity

Tsutomu Nakahara, Kaori Akanuma, Fuka Oikawa, Asami Mori, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 187-187, 2012.

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P2-5-2 Endogenous acetylcholine rescues N-methyl-D-aspartate-induced cell damage via muscarinic receptors in organotypic hippocampal slice cultures

Chikako Inada1, Xoan Li1, Kinzo Matsumoto1, Koichi Tsuneyama2, Takeshi Miyata1, 3
1Inst. Natural Med., Univ. Toyama, 2Grad. Sch. Med, Pharm. Sci., Univ. Toyama, 3Facult. Pharm. Sci., Sojo Univ.
Journal of Pharmacological Sciences 118 (suppl) 187-187, 2012.

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P2-5-3 Activity-dependent nitric oxide signaling protects dopaminergic neurons via protein S-guanylation

Yuki Kurauchi1, 3, Akinori Hisatsune1, Yoichiro Isohama1, Tomohiro Sawa2, Takaaki Akaike2, Hiroshi Katsuki1
1Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ., 2Dept. Microbiol., Grad. Sch. of Med. Sci., Kumamoto Univ., 3JSPS
Journal of Pharmacological Sciences 118 (suppl) 187-187, 2012.

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P2-5-4 Systemic treatment of SUN13837, a novel small molecular compound mimicking the pharmacological actions of bFGF, enhances functional recovery after spinal cord injury in rats

Mariko Kuroda1, Ryoko Ogino1, Yukiko Iwaki1, Shiro Imagama2, Ryoji Tauchi2, Norihito Murayama1, Shinya Ueno1, Yasuhiro Morita3, Naoki Ishiguro2, Teruyoshi Inoue1
1Asubio Pharma, 2Dept. of Orthopaedic Surg., Nagoya Univ. Grad. Sch. of Med., 3Lab. of Physiol. Morphol., Fucl. of Pharmacy, Yasuda Women's Univ.
Journal of Pharmacological Sciences 118 (suppl) 187-187, 2012.

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P2-5-5 Anti-apoptotic effect of temisartan, a partial PPARγ agonist, on cell death induced by stresses relevant to Alzheimer's disease in PC12 cells

Chika Nakayama, Kaori Kubota, Yuki Tsukimori, Akiko Shiraishi, Konoha Takenaka, Shutaro Katsurabayashi, Kotaro Takasaki, Kenichi Mishima, Michihiro Fujiwara, Katsunori Iwasaki
Dept. Neuropharmacol., Fac. Pharmac. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 188-188, 2012.

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P2-5-6 Anti-dementia action of the extracts from Citrus tachibana peels and N chinpi, new beneficial natural resources

Wen Sun1, Ichiro Kawahata1, Masaaki Yoshida2, Daisuke Saigusa3, Akihito Yokosuka4, Yutaka Sashida4, Yoshihiro Mimaki4, Katsuya Saito1, Yoshihisa Tomioka3, Tohru Yamakuni1
1Dept. Pharmacother., Grad Sch of Pharmaceutical Sci, Tohoku Univ., 2Research Laboratory, Kotaro Pharmaceutical Co.,Ltd., 3Dept. Oncol, Pharmacy Practice and Sci, Grad Sch of Pharmaceutical Sci, Tohoku Univ, 4Lab of Med Plant Sci, Sch of Pharmacy, Tokyo Univ of Pharmacy and Life Sci
Journal of Pharmacological Sciences 118 (suppl) 188-188, 2012.

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P2-5-7 Delayed treatment of SUN13837, a novel small molecular compound mimicking pharmacological actions of bFGF, enhances functional recovery without attenuation of infarction after stroke in rats

Ryoko Ogino, Norihito Murayama, Shinya Ueno, Teruyoshi Inoue
Asubio Pharma
Journal of Pharmacological Sciences 118 (suppl) 188-188, 2012.

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P2-5-8 Chronic rotenone exposure affects enteric glial cells

Shinki Murakami, Ikuko Miyazaki, Masato Asanuma
Dept. of Brain Science, Okayama Univ. Grad. Sch. of Med., Dent. & Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 188-188, 2012.

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P2-6-1 The temperature and light period-modified environment in maternal period implicates in the vulnerability to drug and gene-induced schizophrenia phenotypes

Takahiro Nunome1, Akihiro Mouri1, 3, Yuki Aoyama1, 3, Yurie Matsumoto1, 2, Kazuya Toriumi1, 2, Takenao Koseki1, 2, Takayoshi Mamiya1, 2, Akira Sawa4, Kiyofumi Yamada3, Toshitaka Nabeshima1, 2
1Dept. Chemi Pharm., Meijo Univ. Grad. Sch. Pharm., 2Academ. Front. Projt. Priv. Univ., Comp Cognt Sci Inst, Meijo Univ, 3Dept. Neuropsychopharm. and Hospital Pharm., Nagoya Univ. Grad. Sch. of Med., 4Dept. Psychiatry, John Hopkins Univ. Sch. of Med.
Journal of Pharmacological Sciences 118 (suppl) 189-189, 2012.

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P2-6-2 Exposure to enriched environments during adolescence prevents abnormal behaviors associated with histone deacetylation in phencyclidine-treated mice

Takenao Koseki1, 2, Akihiro Mouri1, 3, Takayoshi Mamiya1, 2, Yuki Aoyama1, Kazuya Toriumi1, 2, Shizuka Suzuki1, Azusa Nakajima1, Takuma Yamada1, Taku Nagai3, Toshitaka Nabeshima1, 2
1Dept. Chem. Pharmacol., Grad. Sch. Pharm. Sci., Meijo Univ., 2The Academ. Fron. Proj. Pri. Univ., Compar. Cog. Sci. Insti., Meijo Univ., 3Dept. Neuropsychopharmacol. & Hosp. pharm., Grad. Sch. Med., Nagoya Univ.
Journal of Pharmacological Sciences 118 (suppl) 189-189, 2012.

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P2-6-3 Influence of social defeat stress during the juvenile period on the social behaviors and monoaminergic or endocrine systems in mice.

Mayu Ukai1, Yu Ando1, Akihiro Mouri1, 2, 3, Hirotake Hida1, Masayuki Taniguchi1, Akira Yoshimi1, 3, Kiyofumi Yamada3, Toshitaka Nabeshima2, Norio Ozaki4, Yukihiro Noda1
1Div. Clin Sci Neuropharmacol., Meijo Univ. Fac. Pharm., 2Dept. Chem. Pharmacol., Meijo Univ. Fac. Pharm, 3Dept. Clin. Pharm., Nagoya Univ. Sch. Med, 4Dept. Psychi., Nagoya Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 189-189, 2012.

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P2-6-4 Pubertal Interaction of Mutant DISC1 and Psychological Stress disrupts the serine system and contributes to the aetiopathology of psychiatric disorders

Yurie Matsumoto1, 2, Minae Niwa1, 2, Akihiro Mouri1, 3, Song Ziyu4, Norio Ozaki2, Akira Sawa5, Takeshi Fukushima4, Toshitaka Nabeshima1, 6
1Dept, Chem. Pharmacol., Meijo Univ. Grad. Sch. Pharm. Sci., 2Dept. Psychi, Nagoya Univ. Grad. Sch. Med., 3Dept. Neuropsychopharmacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., 4Dept. Analytical Chem., Toho Univ. Grad. Sch. Pharm. Sci., 5Dept. Psychi. & Behav. Sci., Johns Hopkins Univ. Sch. Med., 6Academic Frontier Project for Private Univ., Camparative Cognitive Sci. Institution, Meijo Univ.
Journal of Pharmacological Sciences 118 (suppl) 189-189, 2012.

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P2-6-5 Psychological stress induces emotional deficits： Involvement of cholecystokinin system

Yuki Tsuruoka1, Takayoshi Mamiya1, 2, Genki Ohashi1, Takenao Koseki1, 2, Kazuya Toriumi1, 2, Akihiro Mouri1, Toshitaka Nabeshima1, 2
1Dept. Chemical. Pharmacol., Meijo Univ. Pharm., 2The Academic Frontier Project for Private Universities, Comparative Cognitive Science Institutes
Journal of Pharmacological Sciences 118 (suppl) 190-190, 2012.

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P2-6-6 Blonanserin improves phencyclidine-induced impairment of recognition memory through dopamine D1 receptor

Hirotake Hida1, Yurie Ogino1, Yurie Matsumoto1, 4, Akihiro Mouri1, 2, 3, Takeshi Seki2, Kiyofumi Yamada3, Norio Ozaki4, Toshitaka Nabeshima2, Yukihiro Noda1
1Div. Clin. Sci. and Neuropsychopharmacology, Meijo Univ. Pharm., 2Dept. Chemical Pharmacol. Meijo Univ. Pharm., 3Dept. Neuropsychopharmacology and Hospital Pharm. Nagoya Univ. Sch. Med., 4Dept. Psychiatry, Nagoya Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 190-190, 2012.

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P2-6-7 Changes in Npas4 expression in the brain after administration of drugs acting on the CNS

Yuki Aoyama1, 2, Taku Nagai1, Toshitaka Nabeshima2, 3, Kiyofumi Yamada1
1Dept. Neuropsychopharm. and Hosp. Pharm., Nagoya Univ., Grad. Sch., Med., 2Dept. Chem Pharm., Meijo. Univ. Grad. Sch. Pharm., 3The Academ. Fron. Proj. for Private Univ., Compar. Cogni. Sci. Insti., Meijo Univ.
Journal of Pharmacological Sciences 118 (suppl) 190-190, 2012.

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P2-6-8 Cholinesterase inhibitors and 5-HT receptor agonists relieve morphine-induced respiratory depression in awake rats.

Satoko Kimura, Yuki Mizuno, Miho Takagi, Yoshiaki Ohi, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 190-190, 2012.

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P2-6-9 Tobacco Smoking Produces Greater Striatal Dopamine Release and Lower Venous Plasma Cortisol Increases in Mu Opioid A118G Alleles

Edward F. Domino, Catherine L Evans, Lisong Ni, Sally K Guthrie, Robert A Koeppe, Jon-Kar Zubieta
Department of Pharmacology, the University of Michigan, USA, University of Michigan
Journal of Pharmacological Sciences 118 (suppl) 191-191, 2012.

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P2-7-1 Distinct receptor tyrosine kinases (RTKs) mediate amitriptyline-induced fibroblast growth factor-2 (FGF-2) expression in rat cortical astrocytes.

Mayu Hosoi1, Mami Okada-Tsuchioka1, Naoto Kajitani1, 3, Ryoya Yano1, 3, Chiyo Shibasaki1, 2, Kazue Hisaoka3, Norimitsu Morioka3, Yoshihiro Nakata3, Minoru Takebayashi1, 2
1Inst. Clin. Res., Natl Hosp Org Kure Med. Ctr., 2Dept. Psychiatry, Natl Hosp Org Kure Med. Ctr., 3Dept. Pharmacol., Hiroshima Univ. Grad. Sch. of Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 191-191, 2012.

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P2-7-2 Astrocytes mediate BDNF exon mRNA expression caused by antidepressants

Masahiro Kaneko1, Kazue Hisaoka1, Naoto Kajitani1, 2, Miho Kasai4, Mami Okada-Tsuchioka2, Norimitsu Morioka1, Minoru Takebayashi2, 3, Yoshihiro Nakata1
1Dept. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Sci., 2Inst. Clin. Res., Natl. Hosp. Org. Kure Med. Ctr., 3Dept. Psychiatry, Natl. Hosp. Org. Kure Med. Ctr., 4Dept. Pharmacol, Hiroshima Univ, Sch of Pharmacy.
Journal of Pharmacological Sciences 118 (suppl) 191-191, 2012.

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P2-7-3 Stimulation of brain-serotonin production by peripherally administered sepiapterin, a precursor of the salvage pathway of tetrahydrobiopterin

Hiroyuki Hasegawa, Akiko Ohashi, Tomonori Harada, Shin Aizawa
Dept. Funct. Morph., Nihon Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 191-191, 2012.

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P2-7-4 Effect of chronic stress induced by repeated oral administration on performances of several behavior tests in ovariectomized mice

Takao Tsukahara1, 2, Tomohiro Nagayama1, Masaaki Masuhara1, Tomoaki Sato1
1Dept. Pharmacol., Kagoshima Univ. Sch. Dent., 2Kagoshima univ. Med. & dent. Hosp.
Journal of Pharmacological Sciences 118 (suppl) 192-192, 2012.

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P2-7-5 Involvement of endoplasmic reticulum stress in the pathophysiology of depression

Youko Ono, Mitsue Ishisaka, Atsushi Oyagi, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 118 (suppl) 192-192, 2012.

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P2-7-6 Chronic stress induces depression-like behavior and attenuates NGF levels in the mouse hippocampus

Yusuke Sakamoto, Haruka Nagai, Maya Noda, Naoya Hasikawa, Narumi Hasikawa-Hobara
Dept. Life Sci., Okayama Univ. Sci.
Journal of Pharmacological Sciences 118 (suppl) 192-192, 2012.

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P2-7-7 Overexpression of a novel molecule "Shati" affects emotional behaviors in mice

Noriyuki Iegaki1, Yoshiaki Miyamoto1, Kyosuke Uno1, Yoko Hibi2, Toshitaka Nabeshima3, Atsumi Nitta1
1Department of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2Dept. of Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. of Med., 3Dept. of Chem. Pharmacol., Grad. Sch. of Pharmaceutical Sci., Meijo Univ.
Journal of Pharmacological Sciences 118 (suppl) 192-192, 2012.

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P2-7-8 Influence of chronic pain on the development of stress adaptation in mice

Kazuya Miyagawa, Minoru Tsuji, Taku Amano, Hiroshi Takeda
Div. Pharmacol., Sch. Pharm., Internat. Univ. Health and Welfare
Journal of Pharmacological Sciences 118 (suppl) 193-193, 2012.

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P2-8-1 Study on molecular mechanisms for interstitial cystitis using a substance P-induced delayed bladder pain model in mice： roles of endogenous hydrogen sulfide and Cav3.2 T-type Ca2+ channels

Maho Matsunami, Yasumasa Okawa, Kazumasa Okubo, Fumiko Sekiguchi, Atsufumi Kawabata
Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 193-193, 2012.

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P2-8-2 Intraplantar injection of gangliosides produces nociceptive behavior via a glutamate signaling mechanism.

Shun Watanabe1, Hideyoshi Higashi2, Kenji Takamori1, Kazuhisa Iwabuchi1
1Inst. for environmental and gender specific medicine, Juntendo Univ., 2Div. Glyco-Signal, Inst. Mol. Biomembrane Glycobio., Tohoku Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 193-193, 2012.

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P2-8-3 Modulation of glycinergic synaptic transmission by blockade of glycine uptake in spinal superficial dorsal horn neurons of adult mice

Seiya Kuraoka1, Hideki Ono1, Mitsuo Tanabe1, 2
1Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Lab. Pharmacol., Sch. Pharm., Kitasato Univ.
Journal of Pharmacological Sciences 118 (suppl) 193-193, 2012.

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P2-8-4 Effects of oxytocin receptor agonists on C-fiber-evoked field potentials and their long-term potentiation in the spinal dorsal horn of rats

Yu Masegi1, Hideki Ono1, Mitsuo Tanabe1, 2
1Lab. CNS Pharmacol., Grad. Sch. Pharm. Sci., Nagoya City Univ., 2Lab. Pharmacol., Sch. Pharm., Kitasato Univ.
Journal of Pharmacological Sciences 118 (suppl) 194-194, 2012.

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P2-8-5 On the role of casein kinase 1 in mouse models of inflammatory and neuropathic pain

Takashi Kurihara1, 2, Eri Sakurai2, Toshihide Asada1, Megumu Yoshimura3, Atsuro Miyata1, Tsutomu Tanabe2
1Dept. Pharmacol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ., 2Dept. Pharmacol. and Neurobiol., Grad. Sch Med., Tokyo Med. and Dent. Univ., 3Grad. Sch. Health Sci., Kumamoto Health Sci. Univ.
Journal of Pharmacological Sciences 118 (suppl) 194-194, 2012.

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P2-8-6 Involvement of altered mu-opioid receptors in spinal cord on the reduced morphine analgesia in inflammatory pain state

Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
Dept. Physiol. Anat. Tohoku Pharmaceut. Univ.
Journal of Pharmacological Sciences 118 (suppl) 194-194, 2012.

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P2-8-7 Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance

Masakazu Ibi, Kuniharu Matsuno, Misaki Matsumoto, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Prefectual Univ. Med.
Journal of Pharmacological Sciences 118 (suppl) 194-194, 2012.

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P2-8-8 Analgesic effects of pregabalin and morphine in a cynomolgus monkey model of neuropathic pain

Masahiko Iino, Mitsuru Hoshino, Atsushi Fujiwara, Yoshio Wakasa
Research Administration Dept. Ina Research Inc.
Journal of Pharmacological Sciences 118 (suppl) 195-195, 2012.

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P2-9-1 Night-time earplug application to prevent delirium in ICU patients

Youhei Takayama1, 2, Makie Higuchi1
1Div. of Pharmacol., Kyushu Univ. of Nurs. & S.W., 2ICU, Saiseikai Kumamoto Hosp.
Journal of Pharmacological Sciences 118 (suppl) 195-195, 2012.

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P2-9-2 Detection of juxtacrine activation of ErbB receptors by BACE1-dependent proteolysis of neuregulin 1 using a cleavage site-specific antibody

Taku Kashiyama, Takashi Sakurai
Dept. Pharmacol., Juntendo Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 195-195, 2012.

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P2-9-3 Role of T-type Ca2+ channels in myenteric AH neurons of the guinea-pig ileum

Hayato Matsuyama1, Trung V. Nguyen2, Toshihiro Unno1, Seiichi Komori1, Michelle Thacker2, Louise Pontell2, Billie Hunne2, Kulmira Nurgali3, John B. Furness2
1Lab. Pharmacol., Dept. Vet. Med., Faculty Appl. Biol. Sci., Gifu Univ., 2Melbourne Uni., Department of Anatomy and Cell Biology, The University of Melbourne, 3Melbourne Uni., Department of Physiology, The University of Melbourne
Journal of Pharmacological Sciences 118 (suppl) 195-195, 2012.

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P2-9-4 Microarray analysis for genes associated with diabetic xerostomia

Di Wang1, Masayuki Shono2, Mayuko Furukita3, Yasuko Ishikawa1
1Dept. Pharmacol, Tokushima Univ. Grad. Sch. Dent., 2Support Center, Inst. Health Biosciences, Tokushima Univ. Grad. Sch., 3Dept. Dental Anesthesiology, Tokushima Univ. Grad. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 196-196, 2012.

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P2-9-5 TRPA1 is a key mediator of oxaliplatin-induced acute cold hypersensitivity

Meng Zhao, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sci. Pharmaceu. Sci., Kyoto Univ
Journal of Pharmacological Sciences 118 (suppl) 196-196, 2012.

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P2-9-6 Carboplatin enhances the activity of human transient receptor potential ankyrin 1 through cyclic AMP-protein kinase A pathways

Kanako Miyano1, Seiji Shiraishi1, Katsuya Ohbuchi2, Yuka Sudo1, 3, Masami Suzuki1, Kiyoshi Terawaki1, Masahiro Yamamoto2, Motohiro Matoba4, Yasuhito Uezono1
1Cancer Pathophysiol. Div., NCCRI., 2Tsumura Research Labs, Tsumura & Co., 3Dept. Mol. Cell. Biol., Nagasaki Univ. Grad Sch. Med. Sci, 4Dept. Palliative Med., NCCH
Journal of Pharmacological Sciences 118 (suppl) 196-196, 2012.

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P2-9-7 Involvement of distinct cAMP-mediating signaling pathways in the preprotachykinin mRNA transcription induced by PACAP in sensory neurons.

Chiharu Fukutomi, Mizuki Fukunaga, Masatoshi Ohnishi, Atsuko Inoue
Dept. Pharmacother. Fac. Pharm. Pharmaceut. Sci., Fukuyama Univ.
Journal of Pharmacological Sciences 118 (suppl) 196-196, 2012.

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P2-10-1 Vasodilating and Vasoconstricting Effects of Orthovanadate

Katsutoshi Yayama, Tomoya Sasahara, Yasumasa Isomoto, Hisaaki Ohba, Hiroshi Okamoto
Lab. Cardiovascular Pharmacol. Dept. Biopharmaceutical Sciences, Kobe Gakuin University
Journal of Pharmacological Sciences 118 (suppl) 197-197, 2012.

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P2-10-2 Change in distribution of NPY Y1 receptor and the response in vascular smooth muscles of SHR

Mitsuhiro Goda, Shin-ichi Murase, Hiroshi Higuchi
Div. Pharmacol, Mol. Cell. Med., Niigata Univ., Grad. Sch. Med. Den. Sci.
Journal of Pharmacological Sciences 118 (suppl) 197-197, 2012.

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P2-10-3 Role of ubiquitination in endothelin receptor trafficking

Koji Terada, Takahiro Horinouchi, Soichi Miwa
Dept. Cell. Pharmacol., Hokkaido Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 197-197, 2012.

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P2-10-4 Phenotype pharmacology of α1-Adrenoceptors in Rat liver

Hatsumi Yoshiki, Abu Syed Md Anisuzzaman, Junsuke Uwada, Atsushi Nishimune, Ikunobu Muramatsu
Div. Pharmacol., Fukui Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 197-197, 2012.

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P2-10-5 Pharmacological intervention of Gbetagamma signal mediated by Activator of G-protein signaling 8 in the cardiomyocytes under hypoxia.

Motohiko Sato, Masahiro Hiraoka, Yukiko Yamane, Xianfeng Feng, Yoshihiro Ishikawa
Cardiovascular Research Institute, Yokohama City University
Journal of Pharmacological Sciences 118 (suppl) 198-198, 2012.

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P2-10-6 Histidine-rich glycoprotein inhibited high mobility group box 1 in complex with heparin -induced angiogenesis in matrigel plug assay

Hidenori Wake1, Shuji Mori2, Hideo K. Takahashi3, Keyue Liu1, Kiyoshi Teshigawara1, Masahiro Nishibori1
1Dept. Pharmacol., Okayama Univ. Grad. Sch. Med., Dent. & Pharm. Sci., 2Shujitsu Univ. Sch. Pharm., 3Dept. Pharmacol., Kinki Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 198-198, 2012.

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P2-10-7 Long-term treatment with losartan augments vasodilator CGRPergic nerve activity in Spontaneously Hypertensive Rats

Yoshito Zamami1, 2, Shingo Takatori1, Narumi Hashikawa3, Hiroko Ishikawa1, Kenji Sasaki2, Hiromu Kawasaki1
1Dept. Clin. Pharmac. Sci., Grad. Sch. Med. Dent. Pharmac. Sci., Okayama Univ., 2Dept. Molc. Desg. Med., Grad. Sch. Med. Dent. Pharmac. Sci., Okayama Univ., 3Dept. Life. Sci., Okayama Univ. Sci.
Journal of Pharmacological Sciences 118 (suppl) 198-198, 2012.

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P2-10-8 Vascular NCX1 contributes to hypertension in pseudohypoaldosteronism type II and cushing's syndrome models.

Satomi Kita1, Yusuke Gotoh1, Shinichi Uchida2, Issei Komuro3, Takahiro Iwamoto1
1Dept Pharmacol, Facul Med Fukuoka Univ., 2Tokyo Medical and Dental and Dental Univ, 3Univ Graduate Sch Med
Journal of Pharmacological Sciences 118 (suppl) 198-198, 2012.

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P2-10-9 Improvement of cardiac remodeling in dilated cardiomyopathy model mice by celecoxib and its derivative 2, 5-dimethyl-celecoxib

Fumi Takahashi, Xueli Fan, Sachio Morimoto, Toshiyuki Sasaguri
Dept. Clin. Pharmacol., Fac. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 199-199, 2012.

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P2-11-1 Analyses for pharmacological and genetic interaction of Apelin and angiotensin signaling in hearts

Teruki Sato, Keiji Kuba, Mizuho Nakayama, Takashi Suzuki, Masayuki Morita, Akihiko Ichikawa, Yumiko Imai
Dept. Biol. Inf., Akita Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 199-199, 2012.

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P2-11-2 Cardioprotective effect of apelin-13 on cardiac performance and remodeling in end-stage heart failure

Naohiko Kobayashi, Hiroshi Takeshima, Wataru Koguchi, Mayuko Ishikawa, Fumihiro Sugiyama, Toshihiko Ishimitsu
Dept, of Hypertens. and Cardiorenal Med. Dokkyo Med. Univ. Sch. of Med.
Journal of Pharmacological Sciences 118 (suppl) 199-199, 2012.

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P2-11-3 SIRT1 suppresses cardiac hypertrophy by downregulating p300 via the ubiquitin-proteasome pathway

Atsushi Kuno1, Tetsuji Miura2, Kazuaki Shimamoto3, Yoshiyuki Horio1
1Dept. Pharmacol., Sapporo Med. Univ., 2Dept. Internal Med. 2, Sapporo Med. Univ., 3Sapporo Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 199-199, 2012.

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P2-11-4 Inhibitory effect of Ascorbic Acid to Ischemia/reperfusion injury at isolated rat heart.

Shintaro Ono1, Fumiaki Nasu1, Yutaka Matsumoto3, Yumi Katano2, Akira Ishihata2
1Grad. Sch. Med., Yamagata Univ. Sch. Med., 2Div. Theoretical Nursing and Pathophysiology, Yamagata Univ. Sch. Med, 3Sch. med., Niigata Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 200-200, 2012.

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P2-11-5 Protective effect of piceatannol on a myocardial ischemia-reperfusion injury

Fumiaki Nasu1, Shintaro Ono1, Yutaka Matsumoto3, Ikuko Kurita4, Shoko Sano4, Yumi Katano2, Akira Ishihata2
1Grad. Yamagata Univ. Sch. Med., 2Div. Theoretic. Nurse. & Pathophysiol., Yamagata Univ. Sch. Med., 3Div. Theoretic. Health. & Maturity., Niigata Univ. Sch. Med., 4Div. Health Care. Morinaga. & Company. limited.
Journal of Pharmacological Sciences 118 (suppl) 200-200, 2012.

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P2-11-6 Chronic inhibition of L/N-type Ca2+ channels prevents heart failure in mice

Naoyuki Kitajima1, Shota Saiki1, Shizuka Aritomi3, Tatsuya Ishikawa3, Michio Nakaya1, Yasuo Mori2, Hitoshi Kurose1, Motohiro Nishida1
1Dept. of Pharmacol. & Toxicol., Grad. Sch. of Pharm. Sci., Kyushu Univ., 2Grad. Sch. of Engin., Kyoto Univ., 3Pharmaceutical Research Laboratories, Ajinomoto Co.
Journal of Pharmacological Sciences 118 (suppl) 200-200, 2012.

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P2-11-7 Properties of cardiomyocytes of DCM mice before and after development of heart failure

Fuminori Odagiri1, 2, 3, Masami Sugihara1, 2, Takeshi Suzuki1, 2, Takashi Murayama1, Yuji Nakazato2, Hiroyuki Daida2, Takashi Sakurai1, Sachio Morimoto3, Nagomi Kurebayashi1
1Dept. Pharmacol., Juntendo Univ. Sch. Med., 2Dept. Cardiol., Juntendo Univ. Sch. Med, 3Dept. Clin Pharmacol., Fac. Med. Kyushu Univ
Journal of Pharmacological Sciences 118 (suppl) 200-200, 2012.

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P2-11-8 Cardiac-specific overexpression of Runx2 mediates cardiac hypertrophy in mice.

Tatsuto Hamatani, Hiroyuki Nakayama, Sachi Matsunami, Reo Matsuo, Yasushi Fujio
Dept. Clin Pharmacol. and Pharmacogenom., Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 201-201, 2012.

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P2-12-1 A relationship between alterations in myosin heavy chain isoform expression and changes in 5-hydroxytryptamine-induced contraction in rabbit jugular vein graft.

Junko Kajikuri1, Takashi Maekawa2, Kimihiro Komori2, Takeo Itoh1
1Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ., 2Dept. Vasc. Surg., Grad. Sch. Med., Nagoya Univ.
Journal of Pharmacological Sciences 118 (suppl) 201-201, 2012.

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P2-12-2 Reduction of inducible NO synthase expression by pulsatile pressure stress in rat vascular smooth muscle cells.

Takuji Machida, Kenji Iizuka, Masahiko Hirafuji
Dpet. Pharmacol. Sci., Sch. Pharm. Sci., Health Sci. Univ. Hokkaido
Journal of Pharmacological Sciences 118 (suppl) 201-201, 2012.

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P2-12-3 Phenotypic change of vascular smooth muscle cells by cyclic stretch and vasoactive substanses effect

Yukiko Kondo, Yasuyuki Irie, Eiichi Taira
Dept. Pharmacol., Iwate Medical Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 201-201, 2012.

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P2-12-4 Pyk2 mediates membrane depolarization-induced RhoA/Rho-associated kinase activation of rat caudal arterial smooth muscle

Jun-ichi Nakagawa1, 2, Mitsuo Mita1, Michael P. Walsh3, Masaru Shoji1
1Dept. Pharmacodyn., Meiji Pharmaceutical Univ., 2Dept. Pharmacy, Hirosaki Univ. Hospital, 3Smooth Muscle Research Group, Univ. Calgary, 3330 Hospital Drive N. W.
Journal of Pharmacological Sciences 118 (suppl) 202-202, 2012.

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P2-12-5 The decrease in the protein level of myosin light chain phosphatase in isolated saphenous vein harvested from patients with diabetes mellitus

Yasuko Matsuo1, Masachika Kuwabara2, Naoko Totoribe1, Tasuku Kanai1, Eisaku Nakamura3, Shuji Gamoh1, Akito Suzuki4, Yujiro Asada5, Hiroaki Hisa6, Ryuichi Yamamoto1
1First Dept. Pharmacol., Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare, 2Kuwabara Clinic, 3Dept. Cardiovasc. Surg. Miyazaki Pref., 4Dept. Clinical Pharmaceutical, Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare, 5Dept. Pathol., Faculty of Med., Miyazaki Univ., 6Second Dept. Pharmacol., Sch. Pharmaceut. Sci., Kyusyu Univ. Hlth. Welfare
Journal of Pharmacological Sciences 118 (suppl) 202-202, 2012.

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P2-12-6 Vaspin inhibits platelet-derived growth factor-induced migration in vascular smooth muscle cells

Sukanya Phalitakul, Muneyoshi Okada, Yukio Hara, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med. Sci
Journal of Pharmacological Sciences 118 (suppl) 202-202, 2012.

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P2-12-7 Maintenance of the contractility of vascular smooth muscle by endothelium-derived proteins

Masahiro Oike, Maki Hasegawa, Chiwaka Kimura
Dept. Pharmacol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 202-202, 2012.

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P2-12-8 Distinct α1-adorenaline receptor subtypes contribute to intra- and extrarenal artery contraction in mice

Koji Nobe
Dept. Pharmacol., Showa Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 203-203, 2012.

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P2-12-9 Taurine-induced modulation of vascular tone in rat mesenteric artery

Seiichiro Nishida1, 2, Hiroyasu Satoh2
1Dongo Hospital, 2Dept. Pharmacol., Nara Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 203-203, 2012.

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P2-13-1 Effects of aspirin on sensitized guinea pigs

Motomu Tanaka, Takaaki Senbonmatsu, Kei Maruyama
Dept. Pharmacol., Saitama Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 203-203, 2012.

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P2-13-2 Whey peptide-based enteral diet suppresses elastase induced-emphysema in mice

Kaoru Kubo1, Koichi Tomoda2, Yasue Nishii3, Atsuhiro Nakamura2, Kaoru Hamada2, Masanori Yoshikawa2, Hiroshi Kimura2
1Lab. Animal Res. Ctr., Nara Med. Univ. Sch. Med., 2Second Dep. Int. Med., Nara Med. Univ. Sch. Med., 3Faculty Health Sci., Kio Univ.
Journal of Pharmacological Sciences 118 (suppl) 203-203, 2012.

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P2-13-3 Co-administration of Picrotoxin with Flumazenil Seems to Show Synergic Antagonistic Effects on Diazepam-induced Hypoglossal Nerve Inhibition

Shinichi Nakamura1, Masahiko Suzuki2, Kazuo Sugita5, Shigeki Sasaki5, Akira Kitamura4, Kei Maruyama3
1Div. Anesth., JA Kumagaya Gen. Hosp., 2Lab. Phamacol., Sch. Med. Tech. and Health, Fac. Health. and Med. Care, Saitama Med. Univ., 3Dept. Pharmacol., Faculty of Med., Saitama Med. Univ., 4Dept. Anesth., Saitama Inter. Med. Cent., 5Div. Pharma., JA Kumagaya Gen. Hosp.
Journal of Pharmacological Sciences 118 (suppl) 204-204, 2012.

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P2-13-4 GABAA mechanism in the NTS involoved in the potentiation of chemoreceptor reflex in chronic intermittent hypoxia exposure rats.

Masahiko Suzuki1, Shinichi Nakamura2, Masami Nishina3, Kazunori Yoshimura4, Yuuki Kawamura5
1Lab. Phamacol., Sch. Med. Tech. and Health, Fac. Health. and Med. Care, Saitama Med. Univ., 2Div. Anesth., JA Kumagaya Gen. Hosp., 3Med. Res. Center, Fac. Med., Saitama Med. Univ., 4Dept. Rehabil., Nihon Inst. Med. Sci., 5Div. Biol., Dept. Basic Sci., Fac. Med., Saitama Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 204-204, 2012.

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P2-13-5 Combination effects of PI3Kγ and δ inhibitors on the corticosteroid-insensitive airway inflammation induced by polyinosinic-polycytidylic acid in mice

Genki Kimura1, Keitaro Ueda1, Shouichi Eto1, Kazuhiro Ito2, Yasuo Kizawa1, Tadashi Kusama1
1Dept. Physiol. & Anat, Nihon Univ. Sch. Pharm., 2NHLI, Imperial Coll.
Journal of Pharmacological Sciences 118 (suppl) 204-204, 2012.

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P2-13-6 Increase in exhaled NO by oral arginine in subjects with a history of allergy

Hiroshi Ogata1, Midori Yatabe1, Shingen Misaka1, Yayoi Shikama1, Suguru Sato2, Mitsuru Munakata2
1Dept. Pharmacol., Fukushima Med. Univ., 2Dept. Pulmo. Med., Fukushima Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 204-204, 2012.

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P2-13-7 Long term exposure to cigarette smoke solution induced the airway remodeling and pulmonary emphysema in guinea pigs

Yuki Nishimoto1, Jun-ichi Fuchikami1, Maki Takahashi1, Yoshitomo Morozumi1, Yasuki Akie1, Akemi Saito1, Hisatoshi Sugiura2, Masakazu Ichinose2, Yoshiki Sakai3
1CMIC BIORESEARCH CENTER Co.,Ltd., 2Department of Internal Medicine, Wakayama Medical University, 3Research Headquarters, Ono Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 205-205, 2012.

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P2-13-8 Novel peptide with broad spectrum antimicrobial activity

Nao Tamura1, Akiko Tennma1, Yoshimi Saito1, Hideki Tomioka1, Takahiro Nakazawa1, Ryuitchi Morishita2
1Dept. Pharmaceu. Res. Dept., AnGes MG, Inc., 2Dept. Clin. Gene Therapy, Osaka Univ. Grad. Sch. Med., Department of Clinical Gene Therapy, Osaka University Graduate school of medicine
Journal of Pharmacological Sciences 118 (suppl) 205-205, 2012.

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P2-14-1 The Influence of Bilateral Adrenalectomy on Indomethacin Induced Small Intestinal Lesions in Rats

Melinda Gyenge, Naoko Abe, Shino Kunimi, Yuuki Sakurai, Kikuko Amagase, Koji Takeuchi
Div. of Path. Sci., Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 205-205, 2012.

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P2-14-2 Cinacalcet, a Calcium-Sensing Receptor Agonist, Prevents NSAID-Induced Small Intestinal Lesions

Kikuko Amagase, Shusaku Hayashi, Naoto Kurata, Yushi Nishimura, Shinichi Kato, Koji Takeuchi
Div. of Path. Sci., Dept. of Pharmacol. & Exp. Ther., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 205-205, 2012.

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P2-14-3 Daikenchuto improves DSS-induced colitis in mice

Shusaku Hayashi, Takeshi Yamamoto, Makoto Kadowaki
Div. of Gastrointestinal Pathophysiology, Inst. Natural Med., Univ. of Toyama
Journal of Pharmacological Sciences 118 (suppl) 206-206, 2012.

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P2-14-4 Tropisetron suppresses DSS-induced colitis via stimulation of α7 nicotinic acetylcholine receptors

Yuichi Tasaka, Katsuya Suemaru, Hiroaki Araki
Div. Pharmacy, Ehime Univ. Hosp.
Journal of Pharmacological Sciences 118 (suppl) 206-206, 2012.

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P2-14-5 Effects of ouabain on high K+-induced contraction in guinea pig ileum and aorta

Takeharu Kaneda, Yuki Suzuki, Yuta Nagai, Tsuyoshi Tajima, Norimoto Urakawa, Kazumasa Shimizu
Labo. Pharmacol., Nippon Vet Univ. Sch. Vet Med.
Journal of Pharmacological Sciences 118 (suppl) 206-206, 2012.

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P2-14-6 IL-17A induces gut smooth muscle cell (SMC) hyper-contractility

Yohei Tokita1, Kazuko Satoh1, Mitsue Nishiyama1, Hirotada Akiho2, 3, Kazuhiko Nakamura2, Ryoichi Takayanagi2, Masahiro Yamamoto1
1Tsumura research laboratories, Tsumura & Co., 2Dept, Medicine and Bioregulatory Sci., Grad. Sch., Kyushu Univ., 3Kitakyushu Municipal Medical Center
Journal of Pharmacological Sciences 118 (suppl) 206-206, 2012.

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P2-14-7 Lauric acid attenuate bovine abomasum contraction

Tsuyoshi Tajima, Naoki Teramoto, Shoko Kusakabe, Rei Aikawa, Kazumasa Shimizu, Norimoto Urakawa, Takeharu Kaneda
Div. Vet. Pharmacol., Nippon Vet. Life Sci. Univ.
Journal of Pharmacological Sciences 118 (suppl) 207-207, 2012.

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P2-14-8 Effects of drugs on non-alcoholic steatohepatitis model in mice

Takahiro Sugiura, Yasushi Hirasawa, Koji Iwata, Takahito Imaizumi, Yukari Matsui, Yukiko Kawasaki, Tohru Toyoshi, Kohei Kyuki
Nihon Bioresearch Inc.
Journal of Pharmacological Sciences 118 (suppl) 207-207, 2012.

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P2-14-9 Prostaglandin E2 suppress HSC activation in the presence of caffeine

Momoka Yamaguchi, Ryota Nishiyama, Shinya Saito, Tomohisa Ishikawa
Grad. Sch. Pharm, Univ. Shizuoka.
Journal of Pharmacological Sciences 118 (suppl) 207-207, 2012.

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P2-15-1 A research to elucidate the major action points and putative target molecules in acidosis-promoted large osteoclast formation

Kohtaro Kato, Ikuo Morita
Dept. Cell. Physiol. Chem., Tokyo Med. and Dent. Univ.
Journal of Pharmacological Sciences 118 (suppl) 207-207, 2012.

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P2-15-2 Suppression of RANKL-dependent heme oxygenase-1 is required for high mobility group box 1 release and osteoclastogenesis

Eiko Sakai1, Megumi Sugawara2, Kazuhisa Nishishita1, Yutaka Fukuma1, Kuniaki Okamoto1, Takayuki Tsukuba1
1Div. Oral Pathopharmacol., Dept. Development. Reconstruct. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci., 2Div. Orthodont. and Biomed. Engineer., Dept. Development. Reconstruct. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci.
Journal of Pharmacological Sciences 118 (suppl) 208-208, 2012.

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P2-15-3 Platinum nanoparticles suppress osteoclast formation and activity through scavenging RANKL induced intracellular ROS productions.

Mayumi Nomura1, 2, Yoshitaka Yoshimura1, Yoshiaki Deyama1, Kuniaki Suzuki1, Nobuo Inoue2
1Dept. Mol. Cell. Pharmacol., Grad. Sch. Dent. Med., Hokkaido Univ., 2Dept. Gerodonto., Grad. Sch. Dent. Med., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 208-208, 2012.

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P2-15-4 Functional analysis of Pax5 in osteoblastic differentiation and maturation

Hiroyuki Fujita, Eiichi Hinoi, Syota Hashizume, Yukio Yoneda
Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech.
Journal of Pharmacological Sciences 118 (suppl) 208-208, 2012.

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P2-15-5 Functional analysis of choline transporters in rheumatoid arthritis synovial fibroblasts

Masato Inazu, Shota Fujii, Tomoya Yamazaki, Satoko Aratani, Toshihiro Nakajima, Kusuki Nishioka
Institute of Medical Science, Tokyo Medical Univ.
Journal of Pharmacological Sciences 118 (suppl) 208-208, 2012.

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P2-15-6 Pathophysiological role of mast cells in collagen-induced arthritis in mice.

Naotaka Shiota, Chiko Shimbori, Hideki Okunishi
Dept. Pharmacol., Shimane Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 209-209, 2012.

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P2-15-7 Spinal ligament cells cultured by explant method have a profile similar to that of mesenchymal stem cells

Toru Asari1, 2, Sunao Tanaka1, 2, Hiroki Mizukami3, Atsushi Ono1, Shunfu Chin1, 2, Yoshifumi Harada1, 2, Soroku Yagihashi3, Shigeru Motomura2, Ken-Ichi Furukawa2, Satoshi Toh1
1Dept. Orthop., Hirosaki Univ. Gradu. Sch. Med., 2Dept. Pharmaco., Hirosaki Univ. Gradu. Sch. Med., 3Dept. Patho. Mole. Med, Hirosaki Univ. Gradu. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 209-209, 2012.

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P2-15-8 Characterization of mesenchymal stem cells from spinal ligaments in patients with Ossification of Posterior Longitudinal Ligament

Yoshifumi Harada1, 2, Toru Asari1, 2, Shunfu Chen1, 2, Atsushi Ono1, Satoshi Toh1, Shigeru Motomura2, Ken-Ichi Furukawa2
1Dept. Orthop. Surg.., Hirosaki Univ. Sch. Med., 2Dept. Pharmacol., Hirosaki Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 209-209, 2012.

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P2-16-1 Imaging of Ca2+ dynamics within the endoplasmic reticulum using a new fluorescent Ca2+ indicator

Junji Suzuki1, Kazunori Kanemaru1, Kuniaki Ishii2, Masamichi Ohkura3, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., Univ., 2Dept. Cardiovasc. Pharmacol., Grad. Sch. Med., Yamagata Univ., 3Brain Sci. Inst., Saitama Univ.
Journal of Pharmacological Sciences 118 (suppl) 209-209, 2012.

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P2-16-2 Knockdown of stromal interaction molecule 1 suppresses store-operated calcium entry and cell proliferation of human epidermoid carcinoma A431 cells

Junko Yohida1, Kuniyoshi Iwabuchi2, Takaharu Ishibashi1, 3, Takayoshi Masuoka1, Matomo Nishio1
1Dept. Pharmacol., Kanazawa Med. Univ., 2Dept. Biochem. I, Kanazawa Med. Univ., 3Pharmacol. Sch. Nurs., Kanazawa Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 210-210, 2012.

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P2-16-3 Increase in intracellular Ca2+ concentration induced by hydrogen sulfide in RIN14B cells

Ayako Ujike, Ken-ichi Otsuguro, Shigeo Ito
Lab. Pharmacol., Grad. Sch. Vet. Med. Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 210-210, 2012.

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P2-16-4 The calcium-dependent regulation of the expression of cystathionine γ-lyase, a hydrogen sulfide-producing enzyme, in mouse pancreatic β-cells

Shigeki Taniguchi1, Toshihide Kimura1, Mitsuhiro Okamoto1, Hideyuki Yamamoto2, Ichiro Niki1
1Dept. Pharmacol., Fac. Med., Oita Univ., 2Dept. Biochem., Grad. Sch. Med., Univ. Ryukyus
Journal of Pharmacological Sciences 118 (suppl) 210-210, 2012.

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P2-16-5 Regulation by intracellular calcium channels of proliferative activity in neural stem/progenitor cells derived from the subventricular zone of adult mice

Tatuo Shiba, Masanori Yoneyama, Kiyokazu Ogita
Dept. Pharmacol., Setsunan Univ.
Journal of Pharmacological Sciences 118 (suppl) 210-210, 2012.

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P2-16-6 Mechanism of apoptosis mediated by T-type channel Cav3.1 on MCF-7 human breast tumor cells.

Tsuyako Ohkubo1, Yoshihiko Okamoto2, Jun Yamazaki1
1Dept. Physiol. Sci. Mol. Biol., Fukuoka Dent. Coll., 2Dept. Oral Maxillofac. Surg., Fukuoka Dent. Coll.
Journal of Pharmacological Sciences 118 (suppl) 211-211, 2012.

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P2-16-7 Regulatory mechanism of endothelin type A receptor-operated Ca2+ entry via TRPC3 and TRPC6 channels.

Tsunaki Higa, Takahiro Horinouchi, Hiroyuki Aoyagi, Koji Terada, Tadashi Nishiya, Soichi Miwa
Dept. Cell. Pharmacol., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 211-211, 2012.

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P2-16-8 Negative regulation of endothelin type A receptor-operated TRPC6 by PKA phosphorylation.

Takahiro Horinouchi, Tsunaki Higa, Hiroyuki Aoyagi, Koji Terada, Tadashi Nishiya, Soichi Miwa
Dept. Cell. Pharmacol., Hokkaido Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 211-211, 2012.

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P2-16-9 Comparison of cell signaling pathways between cell surface and intracellular M1 muscarinic acetylcholine receptors

Junsuke Uwada, Abu Syed MD Anisuzzaman, Atsushi Nishimune, Hatsumi Yoshiki, Ikunobu Muramatsu
Div. Pharmacol., Fukui Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 211-211, 2012.

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P2-17-1 Global analysis of genes involved in down-stream signaling of NOX4/NADPH oxidase regulated by clioquinol

Masato Katsuyama1, Chihiro Yabe-Nishimura2
1RI Ctr., Kyoto Pref. Univ. Med., 2Dept. Pharmacol., Kyoto Pref. Univ. Med.
Journal of Pharmacological Sciences 118 (suppl) 212-212, 2012.

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P2-17-2 FAS pathway is involved in the histone deacetylase inhibitor-induced cell death in PC12 cells.

Daisuke Furuta1, Yuki Hirakawa2, Norihisa Fujita1, 2
1Dept. Infopharmacol. Ritsumeikan Univ. Sch/Pharm., 2Dept. Bioinformatics, Ritsumeikan Univ.
Journal of Pharmacological Sciences 118 (suppl) 212-212, 2012.

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P2-17-3 A crucial role of CNOT3 in stem cell proliferation revealed by conditional gene targeting

Mizuho Nakayama, Takashi Suzuki, Teruki Sato, Masayuki Morita, Yumiko Imai, Keiji Kuba
Dept. Biol. Inf., Akita Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 212-212, 2012.

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P2-17-4 Apoptosis of macropahges by N-arachidonoyl glycine is mediated by GPR18

Rina Takenouchi, Kazuhiko Inoue, Yuki Kambe, Takashi Kurihara, Atsuro Miyata
Dept. Pharmacol., Kagoshima Univ. Grad. Sch. Med. and Dent. Sci.
Journal of Pharmacological Sciences 118 (suppl) 212-212, 2012.

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P2-17-5 Monad regulates stability of Amphiregulin mRNA

Kyoko Kurioka1, Makio Saeki1, Yasuyuki Irie2, Yoshinori Kamisaki1
1Department of Pharmacology, Graduate School of Dentistry, Osaka University, 2Department of Pharmacology, Iwate Medical School
Journal of Pharmacological Sciences 118 (suppl) 213-213, 2012.

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P2-17-6 Role of hydrogen peroxide in the cytotoxicity induction by sodium 5, 6-benzylidene-L-ascorbate and benzaldehyde

Mariko Ishihara1, Hiroshi Sakagami2, Jun Saitoh3, Atsuko Kochi3
1Div. Basic Chem., Meikai Univ. Sch. Dent., 2Div. Pharmacol., Meikai Univ. Sch. Dent., 3Ichijokai Hospital
Journal of Pharmacological Sciences 118 (suppl) 213-213, 2012.

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P2-17-7 The synergistic toxicity of the combination of 15-deoxy-△12, 14-prostaglandin J2 and several anti-tumor agents against renal cell carcinoma

Yasuhiro Yamamoto1, Hiromi Koma2, Megumi Fujita3, Motohiro Yamamori3, Noboru Okamura3, Tsutomu Nakamura2, Tatsurou Yagami1
1Div. Physiol., Fac. Pharmaceut. Sci., Himeji Dokkyo Univ., 2Div. Pharmaceutics, Fac. Pharmaceut. Sci., Himeji Dokkyo Univ., 3Div. Clin. Pharm., Fac. Pharmaceut. Sci., Mukogawa Women's Univ.
Journal of Pharmacological Sciences 118 (suppl) 213-213, 2012.

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P2-17-8 The inhibition of DUSP-1 expression enhances anti-tumor effects of differentiation-inducing factor-1 in HeLa cells

Tatsuya Yoshihara, Fumi Takahashi, Toshiyuki Sasaguri
Dept. Cli. Pharmacol., Fac. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 213-213, 2012.

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P2-18-1 Improvement of method for making cell lines as the disease model for malignant hyperthermia

Masahide Nakano1, Hideto Oyamada1, Kentaro Yatomi1, Toshiko Yamazawa2, Takashi Murayama3, Takashi Sakurai3, Masamitsu Iino2, David H. MacLennan4, Katsuji Oguchi1
1Dept. Pharmacol., Showa Univ. Sch. Med., 2Dept. Mol. Cell. Pharmacol., Univ of Tokyo, 3Dept. Pharmacol., Juntendo Univ. Sch. Med., 4Banting and Best Dept. of Medical Research, Univ of Tronto, Best Institute.
Journal of Pharmacological Sciences 118 (suppl) 214-214, 2012.

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P2-18-2 Effects of postprandial hypertriglyceridemia on platelet aggregability and nitric oxide in rabbits

Saori Hishinuma1, Youhei Abe1, Tsunekata Ito3, Yumi Katano2, Akira Ishihata2
1Grad. Sch. Med., Yamagata Univ. Sch. Med., 2Div. Theoretical Nursing and Pathophysiology, Yamagata Univ. Sch. Med, 3Lab. Animal Ctr., Sch. Med., Yamagata Univ
Journal of Pharmacological Sciences 118 (suppl) 214-214, 2012.

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P2-18-3 Estrogen deficiency impairs sensitivity of the baroreceptor reflex (baroreflex) and vasomotor functions in the aorta

Yasutoshi Hirabara1, 2, Sayo Tumura1, Sayaka Morimoto1, Yuuya Hirata1, Tomohiro Ogasawara1, Kenji Honda1, Ryo Saito1, Hideki Shuto3, Yasufumi Kataoka3, Yukio Takano1
1Dept. Pharmacol. Fac. Pharmaceutical Sci. Fukuoka Univ., 2Dept. Pharmacy, Univesity Miyazaki Hospital, 3armaceutical Care and Health Sci. Fac. Pharmaceutical Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 214-214, 2012.

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P2-18-4 Indoxam, a phospholipase A2 inhibitor, prolongs survival period without Iowering pulmonary arterial pressure in rats with monocrotaline-induced pulmonary hypertension

Maki Saito1, Yoshiyuki Tanabe1, Akihisa Kamataki2, Takashi Sawai2, Miku Kanno1, Masamichi Hirose1, Koichi Nakayama1
1Dept. Mol. Cell. Pharmacol., Iwate Med. Univ. Sch. Pharm. Sci., 2Dept. Pathol., Iwate Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 214-214, 2012.

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P2-18-5 Development of a new model for abdominal aortic aneurysm (AAA) in mice.

Emi Morita, Ryoji Mizumachi, Takayuki Tokutomi, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Pharmacology Department, Nonclinical Research Center Drug Development Service Segment, MITSUBISHI CHEMICAL MEDIENCE CORPORATION
Journal of Pharmacological Sciences 118 (suppl) 215-215, 2012.

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P2-18-6 Effects of a human glucagon-like peptide-1 analog in the WBN/Kob-Leprfa rat, a novel type 2 diabetes model

Dai Nagakubo, Yuki Nakamura, Chika Arisato, Ayami Takasugi, Sena Watanabe, Noriyuki Kaji, Mitsuyuki Shirai, Fumitoshi Asai
Dept. Vet. Pharmacol., Azabu Univ. Sch. Vet. Med.
Journal of Pharmacological Sciences 118 (suppl) 215-215, 2012.

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P2-18-7 DNA microarray analysis in cultured aortic endothelial cells from a spontaneous type 2 diabetes rat model

Reiko Ishii-Nozawa, Yoshihiro Uesawa, Kiminori Mohri
Dept. Clin. Pharm., Meiji Pharmaceut. Univ.
Journal of Pharmacological Sciences 118 (suppl) 215-215, 2012.

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P2-18-8 Accumulated iron storage in high fat diet-induced obese and diabetic mice

Noriko Yamano1, Yasumasa Ikeda1, Minoru Sakama2, Yuki Ishizawa1, Yoshitaka Kihira1, Keisuke Ishizawa3, Shuhei Tomita1, Koichiro Tsuchiya3, Toshiaki Tamaki1
1Dept. of Pharmacol., Inst. Health Biosciences, Univ. of Tokushima Grad. Sch., 2Dept. of Radiol. Sci., Inst. Health. Biosciences, Univ. of Tokushima Grad. Sch., 3Dept. of Med. Pharmacol., Inst. Health Biosciences, Univ. of Tokushima Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 215-215, 2012.

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P2-18-9 Hepatic gene expression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) model rats using DNA microarray analysis.

Keiichiro Ohba1, 3, Shinichi Iwai1, Minoru Watanabe4, Naoki Matsumoto2, Go Koizumi1, 3, Go Oda3, Toshio Kumai3, Shinichi Kobayashi1, Katsuji Oguchi1
1Dept. Pharmacol. Showa Univ. Sch. Med., 2Dept. Pharmacol. St. Marianna Univ. Sch. Med., 3Dept. Pharmacogenom., St. Marianna Univ. Grad. Sch. Med., 4Inst. Animal Exp., St. Marianna Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 216-216, 2012.

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P2-19-1 Nonclinical studies of monoclonal antibodies for human use approved in 2011

Tamiko Suzuki-Nishimura, Kazuki Ono, Atsuki Tsuchiya, Keiichi Nakayama, Ayaka Kawakami
Dept Pharmacol, School of Pharmacy, Shujitsu Univ
Journal of Pharmacological Sciences 118 (suppl) 216-216, 2012.

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P2-19-2 Effects of some antioxidant compounds on three types of inflammation models

Mitsunobu Mio, Yoshikazu Ishii, Shun-ichi Ohata, Keisuke Yoshii
Dept. Pharmacol., Shujitsu Univ., Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 216-216, 2012.

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P2-19-3 Selective and potent activation of human TRPA1 by a disease modifying anti-rheumatic drug, auranofin

Noriyuki Hatano, Erika Kusugami, Erina Kamiya, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki
Lab. Cellular Pharmacol., Sch. Pharm., Aichi-gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 216-216, 2012.

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P2-19-4 Active constituents of the extract from Nandina domestica Thunberg responsible for inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in A549 cells

Takuro Ueki1, Tatsuhiro Akaishi1, Hedenobu Okumura2, Kazuho Abe1
1Lab. Pharmacol., Fac. Pharm., Musashino Univ., 2TOKIWA Pharmaceut, Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 217-217, 2012.

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P2-19-5 Larix sibirica defend experomental fulminant hepatitis induced by ConA

Sumika Toyama1, 2, Jiajie Chen1, 3, Xiao-Kang Li1
1National Research Institute for Child Health & Development, 2Tokyo Denki university, 3Huashan Medical Center
Journal of Pharmacological Sciences 118 (suppl) 217-217, 2012.

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P2-19-6 Improvement of an Atopic Dermatitis Model Prepared by Repeated Application of Dermatophagoides farinae in Mice

Yukiko Kawasaki, Yasushi Hirasawa, Shoko Otsu, Takahiro Sugiura, Tohru Toyoshi, Kohei Kyuki
Nihon Bioresearch Inc.
Journal of Pharmacological Sciences 118 (suppl) 217-217, 2012.

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P2-19-7 In vivo imaging of damage associated molecular patterns (DAMPs) DNA in mouse lungs with ARDS

Akihiko Ichikawa, Masayuki Morita, Keiji Kuba, Yumiko Imai
Dept. Biol. Inf, Akita Univ. Sch Med
Journal of Pharmacological Sciences 118 (suppl) 217-217, 2012.

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P2-19-8 Lipidomics analysis of polyunsatulated fatty acids metabolites in the influenza virus-infected lungs

Masayuki Morita, Akihiko Ichikawa, Keiji Kuba, Yumiko Imai
Dept. Biological Informatics and Experimental Therapeutics. Akita Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 218-218, 2012.

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P2-19-9 IL-1β decreases aquaporin-3 expression via trans-repression by C/EBP in lung epithelial cells

Ichiro Horie1, 2, Akinori Hisatsune1, Hiroshi Katsuki1, Yoichiro Isohama1
1Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ., 2Dept. Pharmacol., Facul. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 218-218, 2012.

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P2-20-1 Yokukansan, a traditional Japanese herbal medicine, improve the emotional abnormality induced by maladaptive to stress in mice

Minoru Tsuji, Tomoko Takeuchi, Kazuya Miyagawa, Hiroshi Takeda
Div. Pharmacol., Sch. Pharm., Internat. Univ. Health and Welfare
Journal of Pharmacological Sciences 118 (suppl) 218-218, 2012.

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P2-20-2 Study on Antipsychotic Activity of Alkaloids from Uncaria rhynchophylla

Nakazawa Takahiro, Tatsuya Hakamada, Tomoaki Sanekata, Nana Tamura, Miho Chiba, Yukie Mitsuzuka, Nana Yoshida, Michio Namikoshi
Dept. Nat. Prod. Chem., Tohoku Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 218-218, 2012.

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P2-20-3 Anti-liver cancer and analgesic effects of traditional Chinese medicine Liu-Shen-Wan

Mei-Mei Jia1, Yu-Sang Li1, Jie Yang2, Yan-Ling Yang1, Min Liu1, Xiao-Jun Li1, He-Bin Tang1
1Dept. Pharmacol., S Cent Univ Nationalities, Coll Pharm., 2Huazhong Univ Sci & Technol, Coll Chem & Chem Engn
Journal of Pharmacological Sciences 118 (suppl) 219-219, 2012.

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P2-20-4 San-o-shashinto reduces cardiac ischemia-reperfusion injury in ovariectomized female rats though selective activation of manganese superoxide dismutase

Mayuko Sakanashi1, Katsuhiko Noguchi1, Toshihiro Matsuzaki1, Junko Nakasone1, Kumiko Arakaki2, Taro Uchida1, Makiko Sakanashi3, Haruaki Kubota3, Mika Tanada1, Yusuke Ohya2, Kazuhiro Sugahara3, Matao Sakanashi4, Masato Tsutsui1
1Dept. Pharmacol., Grad. Sch. Med., Univ. of the Ryukyus, 2Dept. Cardiovasc. Med. Nephrol. Neurol., Grad. Sch. Med., Univ. of the Ryukyus, 3Dept. Anesth., Grad. Sch. Med., Univ. of the Ryukyus, 4Univ. of the Ryukyus
Journal of Pharmacological Sciences 118 (suppl) 219-219, 2012.

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P2-20-5 Chinese Herbal Compound Sanhuangshenfu Oil enhanced skin regeneration and scarless repair of third-degree scald burned rabbits

Yu-Sang Li1, Mei-Mei Jia1, Lan-Jie Pei1, Yan-Ling Yang1, Min Liu1, Xiao-Kuan Li2, He-Bin Tang1
1Dept. Pharmacol., S Cent Univ Nationalities, Coll Pharm., 2Analytical and Testing Center, S Cent Univ Nationalities
Journal of Pharmacological Sciences 118 (suppl) 219-219, 2012.

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P2-20-6 Analgesic action of chitin oligosaccharides and chitosan oligosaccharides

Rie Terasawa, Norihumi Yonehara
Dept. Dental Pharmacol., Ohu Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 219-219, 2012.

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P2-20-7 Evodiamine activates TRPV1 in primary sensory neurons.

Emiko Iwaoka1, Nobuyuki Matsuyoshi1, Yoko Kogure1, 2, Shunji Aoki1, Satoshi Yamamoto1, Koichi Noguchi2, Yi Dai1, 2
1Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Anatomy and Neuroscience., Hyogo Col. Med.
Journal of Pharmacological Sciences 118 (suppl) 220-220, 2012.

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P2-20-8 Constituents of Phalaenopsis Hybrids (Orchidaceae) Showing an Inhibitory Effect on Activated Matrix Metalloproteinases

Kenroh Sasaki, Daiki Sato, Toshihiro Murata, Fumihiko Yoshizaki
Dept. Pharmacognosy, Tohoku Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 220-220, 2012.

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P2-20-9 Evaluation of the teratogenicity and reproductive toxicity of the aqueous extract of Labisia pumila var. alata in female rats

Wan Ezumi Mohd Fuad1, Siti Amrah Sulaiman2, Hasnan Jaafar3, Syed Mohsin Sahil Jamalullail1
1Programme of Biomedicine, School of Health Sciences, Universiti Sains Malaysia Health Campus, 2Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 3Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus
Journal of Pharmacological Sciences 118 (suppl) 220-220, 2012.

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P2-21-1 TiO2 particles induce apoptosis associated with chromosomal giant DNA fragmentation and caspase-3 activation in L1210 leukemia cells.

Yoshihiko Higuchi1, Keiko Takaki2, Ayako Furukawa1, Minako Hashii3, Nobuaki Shimizu2
1Dept. Pharmacol., Suzuka Univ. Med. Sci., 2Inst. Nat. Envir. Tech., Kanazawa Univ., 3Dept. Biophys. Genet., Kanazawa Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 220-220, 2012.

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P2-21-2 Role of the caspase cascade in synthetic cannabinoid-induced cytotoxicity in NG 108-15 cells

Masahiko Funada, Ken-ichi Tomiyama, Kiyoshi Wada
Dept. Drug Dependence Res., NIMH, NCNP
Journal of Pharmacological Sciences 118 (suppl) 221-221, 2012.

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P2-21-3 The peroxidase activity of bleomycin-Fe3+ is associated with the generation of hydroxyl radicals and degradation of DNA

Toshiaki Miura
Dept. Biology, Hokkaido Pharm. Univ. Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 221-221, 2012.

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P2-21-4 Effects of ARB on cultured rat embryos

Atsushi Yokoyama1, Masaharu Akita2
1Kanagawa Life-sciense Research, 2Kamakura woman's college
Journal of Pharmacological Sciences 118 (suppl) 221-221, 2012.

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P2-21-5 Involvement of hypothalamic cyclooxygenase-2 in the development of docetaxel-induced anorexia in rats

Kouichi Yamamoto, Naoki Matsukawa, Yui Ito, Masanori Kunisawa, Keiko Asano, Atsushi Yamatodani
Lab. Pharmacol., Dept. Med. Sci. Tech. Div. Health Sci., Grad. Sch. Med., Osaka Univ.
Journal of Pharmacological Sciences 118 (suppl) 221-221, 2012.

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P2-21-6 Discrimination of PPARα agonists in the rat liver transcriptome database and its verification.

Yumiko Mizukawa1, Yuji Morikawa2, Noriyuki Nakatsu2, Atsushi Ono3, Hiroshi Yamada2, Yasuo Ohno4, Tetsuro Urushidani1, 2
1Dept. Pathophys., Faculty of Pharmaceutical Sci., Doshisha Women's College, 2Toxicogenomics Informatics Project, Natl. Inst. Biomed. Innov., 3Div. Risk Assessment, Natl. Inst. Health Sci., 4Natl. Inst. Health Sci.
Journal of Pharmacological Sciences 118 (suppl) 222-222, 2012.

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P2-21-7 Effects of antilipemic agent on SHRSP fed diet containing canola oil

Yukiko Naito1, Shigehiro Tachibana2, Eriko Ando2, Mami Furuya2, Tomoko Nagata2, Xu Ji1, Xiao Ma1, Kosuke Endo1, Naoharu Iwai1
1Dept. Genomic Med., NCVC, 2FDSC
Journal of Pharmacological Sciences 118 (suppl) 222-222, 2012.

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P2-21-8 Nano-sized silica particles localize in the cell membrane and inhibit exclusion of Adriamycin in multidrug-resistant L1210/ADM cells.

Daisaku Miura1, Manabu Kobayashi1, Yuuta Inoue1, Teppei Koreeda1, Tatsuya Ootoshi1, Naohiko Anzai2, Ken-ichi Kiyomiya1
1Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Pharmacol. Toxicol., Dokkyo Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 222-222, 2012.

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P2-21-9 A screening method for safety evaluation of nanomaterials.

Daisaku Miura1, Atsuyoshi Namura1, Tomohiro Miura1, Tatsuya Ootoshi1, Risa Tanaka1, Miwa Ayajiki1, Naohiko Anzai2, Ken-ichi Kiyomiya1
1Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Pharmacol. Toxicol., Dokkyo Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 222-222, 2012.

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P3-1-1 Peripherally administered ghrelin modulates the mesolimbic dopamine system via distinct opioid pathways associated with reward value of food

Yukie Kawahara1, Fumi Kaneko1, Makiko Yamada1, Yuki Furushima1, Hiroshi Kawahara2, Akinori Nishi1
1Dept. Pharmacol., Kurume Univ. Sch. Med., 2Dept. Dent. Anesthesiol. Tsurumi Univ Sch. Dent. Med.
Journal of Pharmacological Sciences 118 (suppl) 223-223, 2012.

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P3-1-2 Distribution and pharmacological characterization of primate NK-1, NK-2 and NK-3 tachykinin receptors in the central nervous system of the rhesus monkey.

Masatoshi Nagano1, Takao Oishi2, Motoharu Hayashi2, Hidenori Suzuki1
1Dept. Pharmacol., Nippon Med. Sch., 2Dept. Cell. Mol. Biol., Primate Res Inst., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 223-223, 2012.

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P3-1-3 Properties of GABAA receptors containing the γ2 N40S mutation associated with seizures

Keisuke Migita1, Junko Yamada1, Xiu Yu Shi3, 4, Sunao Kaneko2, Shinichi Hirose3, 5, Shinya Ueno1
1Dept. Neurophysiol., Hirosaki Univ. Sch. Med., 2Dept. Neuropsychiatry, Hirosaki Univ Sch. Med., 3Dept. Pediatrics, Fukuoka Univ. Sch. Med., 4Dept. Pediatrics, Chinese PLA General Hospital, 5Central Research Institute for the Pathomechanisms of Epilepsy, Fukuoka Univ
Journal of Pharmacological Sciences 118 (suppl) 223-223, 2012.

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P3-1-4 Comparison of the dorsal raphe serotonergic circuitry in WKY and Wistar rat strains

Makiko Yamada1, Yukie Kawahara1, Fumi Kaneko1, Yuki Furushima1, Dremencov Eliyahu2, Hirosi Kawahara3, Akinori Nishi1
1Dept. Pharmacol., Kurume Univ. Sch. Med., 2Brains On-Line B. V., University of Groningen, 3Dept. Dental Anesthesiology, Tsurumi Dental College
Journal of Pharmacological Sciences 118 (suppl) 223-223, 2012.

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P3-1-5 Effects of three peptidase inhibitors on anti-nociceptive action of Dynorphin A by intrathecal administration in rats

Junko Ajimi1, Masaaki Miura1, Shigeru Takahashi2, Mariko Watanabe1, Masanobu Yoshikawa2, Toshiyasu Suzuki1
1Dept. Anesth., Tokai Univ. Sch Med, 2Dept Clin. Pharmacol.
Journal of Pharmacological Sciences 118 (suppl) 224-224, 2012.

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P3-1-6 Responses of insular cortical neurons to orofacial noxious stimulation

Kazunori Adachi1, Yuji Beppu2, Noriaki Koshikawa3, Hiroshi Sakagami1, Jun Shimada2, Masayuki Kobayashi3
1Div. Pharmacol. Meiaki Univ. Sch. Dent., 2Div. Oral Maxillo. Surg 1., Meiaki Univ. Sch. Dent., 3Dept. Pharmacol., Nihon Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 224-224, 2012.

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P3-1-7 The α1 adrenoceptor in the nucleus accumbens plays an inhibitory role on accumbal noradrenaline and dopamine efflux in freely moving rats

Tadashi Saigusa1, Yuri Aono1, A. R. Cools2, Noriaki Koshikawa1
1Dept. Pharmacol., Nihon Univ. Sch, Dent., 2Psychoneuropharmacol., Dept. Cognitive Neurosci. Radboud Univ.
Journal of Pharmacological Sciences 118 (suppl) 224-224, 2012.

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P3-1-8 Effects of the selective β1-and β2-adrenoceptor agonists on the accumbal noradrenaline and dopamine efflux in freely moving rats

Yuri Aono1, Tadashi Saigusa1, A. R. Cools2, Noriaki Koshikawa1
1Dept. Pharmacol., Nihon Univ. Sch. Dent., 2Psychoneuropharmacol., Dept. Cognitive Neurosci. Radboud Univ.
Journal of Pharmacological Sciences 118 (suppl) 224-224, 2012.

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P3-2-1 Effects of intracellular glutathione control on α-synuclein-transfected cells

Ken-ichi Tanaka1, 2, Kanako Sonoda2, 3, Kanako Narahara2, Masato Asanuma3
1Physiol. & Pharmacol., Saitama Pre. Univ., 2Shujitsu Univ. Sch. Pharma., 3Okayama Univ. Grad. Sch. Med. Dent. Pharma. Sci.
Journal of Pharmacological Sciences 118 (suppl) 225-225, 2012.

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P3-2-2 The involvement of GPNMB in nuronal cell death by endoplasmic reticulum stress

Masafumi Takata, Hirotaka Tanaka, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol. Dept. Biofunct. Eval., Gifu Pharmaceut. Univ.
Journal of Pharmacological Sciences 118 (suppl) 225-225, 2012.

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P3-2-3 Centrally acting antitussives inhibit the dopamine D2 receptor-mediated GIRK current in VTA neurons.

Ryota Hamasaki, Tetsuya Shirasaki, Fumio Soeda, Kazuo Takahama
Dept. Environ. Mol. Health Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 225-225, 2012.

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P3-2-4 Enhanced expression of naofen induction by bupivacaine in Neuro2a cells

Lei Huang, Guo-Gang Feng, Jun-Hua Fan, Koji Tsunekawa, Fumio Kondo, Naohisa Ishikawa, Shoshiro Okada
Dept. Pharmacol., Aichi Med. Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 225-225, 2012.

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P3-2-5 AVP4-9, a major vasopressin metabolite, attenuates amyloid β1-42-induced apoptosis in rat hippocampal neurons.

Yasuhisa Nakayama, Tomoyuki Nakamura
Dept. Pharmacol., Kansai Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 226-226, 2012.

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P3-2-6 Decreased activity of GABA neurons in the central reward system of high-fat diet-induced obese mice

Susumu Koyama
Dept. Psychosom. Med., Fac. Pharm. Sci., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 226-226, 2012.

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P3-2-7 Exploration of a new class of anti-obesity agents which targets ER stress

Rie Yamaguchi, Toru Hosoi, Sachiko Baba, Keisuke Toyoda, Kikuko Noji, Koichiro Ozawa
Dept. Pharmacother., Grad. Sch, Biomed. Sci. Hiroshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 226-226, 2012.

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P3-2-8 A novel compound ameliorating leptin resistance induced by endoplasmic reticulum stress in obesity

Keisuke Toyoda1, Toru Hosoi2, Koichiro Ozawa2
1Facul. Pharmaceut. Sci., Hiroshima Univ., 2Dept. Pharmacother., Grad. Sch, Biomed. Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 226-226, 2012.

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P3-3-1 Secretome analysis in polyl：C-treated astrocyte-conditioned medium

Shinnosuke Yamada, Taku Nagai, Daisuke Ibi, Kiyofumi Yamada
Dept. Neuropsychopharmacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 227-227, 2012.

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P3-3-2 Noradrenaline protects neurons from H2O2-induced cell death by increasing the supply of glutathione from astrocytes.

Yasuhiro Yoshioka, Toshiki Motegi, Chiharu Shirasu, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ.
Journal of Pharmacological Sciences 118 (suppl) 227-227, 2012.

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P3-3-3 Mechanism of thymidine incorporation into acid insoluble fraction on oxidative stress DNA injury

Koh-ichi Tanaka1 2, 3, Nobue Kitanaka2, Junichi Kitanaka2, Shyohn Yokoyama1, Yuriko Kishi1, Tomoaki Sato3, Takashige Nishikawa3, Motohiko Takemura2, Akemichi Baba1, Nobuyoshi Nishiyama1
1Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci., 2Dept. Pharmacol., Hyogo Col. Med., 3Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. & Dent. Sci.
Journal of Pharmacological Sciences 118 (suppl) 227-227, 2012.

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P3-3-4 Aquaporin 4 has a functional role for activation of glial cells in injured mouse brain

Hiroko Ikeshima-Kataoka, Yoichiro Abe, Sayaka Inui, Masato Yasui
Dept. Pharmacol. & Neurosci., Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 227-227, 2012.

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P3-3-5 Role of transcription factor MafB in microglial activation

Sosuke Yoneda, Hidetoshi Saitoh, Junya Masuda, Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 228-228, 2012.

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P3-3-6 Expression analysis of astrocytic Kir4.1 channels in a rat model of temporal lobe epilepsy.

Takahiro Mukai, Yuki Nagao, Yuya Harada, Aoi Okuda, Megumi Fujimoto, Asuka Ono, Yoshihisa Sakagami, Saki Shimizu, Yoshiko Kawai, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm Sci.
Journal of Pharmacological Sciences 118 (suppl) 228-228, 2012.

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P3-3-7 Distinct cellular responses to Toll-like receptor 4 activation in microglia： modulation via purinergic receptors

Izumi Hide1, Kana Harada1, Takahiro Seki1, Shigeru Tanaka1, Yuhki Yanase2, Norio Sakai1
1Dept. Mol. and Pharmacol. Neurosci., Grad. Sch. Biomed. Sci., Hiroshima Univ., 2Dept. Dermatol., Grad. Sch. Biomed. Sci., Hiroshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 228-228, 2012.

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P3-3-8 Transcriptional regulation of the mouse aquaporin-4 M23 promoter in astrocytes

Yoichiro Abe, Hiroko Ikeshima-Kataoka, Wakami Goda, Masato Yasui
Dept. Pharmacol. Keio Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 228-228, 2012.

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P3-4-1 Effect of fluoxetine on motor function in a hemiparkinsonian rat model

Masatoshi Inden1, 2, Kazuyuki Takata2, Yoshihisa Kitamura2
1Clin. Pharmacol. Lab., College of Pharm. Sci., Ritsumeikan Univ., 2Dept. Neurobiol., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 229-229, 2012.

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P3-4-2 Involvement of IL-1 in Lipopolysaccharide-induces Parkinson disease animal model

Sachiko Tanaka1, Atsuko Ishii1, Hirokazu Ohtaki2, Seiji Shioda2, Takemi Yoshida1, Satoshi Numazawa1
1Dept. Biochem. Toxicol., Showa Univ. Sch. Pharm., 2Dept. Anatomy, Showa Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 229-229, 2012.

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P3-4-3 Effect of G-CYPMPO, a novel radical trapper, against dopaminergic neurodegeneration in a hemiparkinsonian rat model

Yoshihisa Kitamura1, Masatoshi Inden1, 2, Masato Kamibayashi3, Kazuyuki Takata1
1Dept. Neurobiol., Kyoto Pharm. Univ., 2Clin. Pharmacol. Lab., College of Pharm. Sci., Ritsumeikan Univ., 3Dept. Pharm. Manuf. Chem., Kyoto Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 229-229, 2012.

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P3-4-4 Structural requirements for the flavonoid fisetin in inhibiting fibril formation of non-Aβ component of Alzheimer's disease amyloid

Tatsuhiro Akaishi1, Maya Kashima1, Kiyomi Ogawa1, Tomohiro Asakawa2, Toshiyuki Kan2, Kazuho Abe1
1Lab. Pharmacol., Fac. Pharm., Musashino Univ., 2Syn. Org. & Med. Chem., Sch. Pharmaceut. Sci., Univ. Shizuoka
Journal of Pharmacological Sciences 118 (suppl) 229-229, 2012.

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P3-4-5 Osteopontin expression in the mouse model of amyotrophic lateral sclerosis

Shogo Tanabe1, Yasuhiro Moriwaki1, Koji Yamanaka2, Hidemi Misawa1
1Dept. Pharmacol., Fac. Pharm. Keio Univ., 2Lab. for Motor Neuron Disease, RIKEN Brain Science Institute
Journal of Pharmacological Sciences 118 (suppl) 230-230, 2012.

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P3-4-6 Expression and cellular localization of microsomal prostaglandin E synthase-1 in the spinal cord in a transgenic mouse model of amyotrophic lateral sclerosis

Hiroko Miyagishi, Yasuhiro Kosuge, Nobuhiro Osada, Kumiko Ishige, Yoshihisa Ito
Lab., of Pharmacol., Sch. of Pharm., Nihon Univ.
Journal of Pharmacological Sciences 118 (suppl) 230-230, 2012.

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P3-4-7 Comparative mutant mouse studies on the D1 receptor-mediated regulation of orofacial movement： forebrain vs striatum

Katsunori Tomiyama1, 2, Hyun Ah Kim4, Anthony Kinsella5, Michelle E. Ehrlich6, Gunter Schutz7, Noriaki Koshikawa2, 3, Andrew J. Lawrence4, John L. Waddington5, John Drago4
1ARISH, Nihon Univ., 2Nihon Univ. Sch. Dent. Dept. Pharmacol., 3Dent. Res. Cente, UNSD, 4Howerd Florey Neurosci. Int. & Centre for Neurosc. Univ., 5Mol. & Cel. Therapeutics, RCSI, 6Dept. Nerology, Pediat., Gen. & Gen. Sci., Mt. Sinai Sch. Med., 7Deut. Krebsforshungszentrum
Journal of Pharmacological Sciences 118 (suppl) 230-230, 2012.

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P3-4-8 Domoic acid increases Naofen expression in the rat hippocampus

Koji Tsunekawa, Fumio Kondo, Lei Huang, Guo-Gang Feng, Jun-Hua Fan, Naohisa Ishikawa, Shoshiro Okada
Dept. Pharmacol., Aichi Med Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 230-230, 2012.

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P3-5-1 Role for IFITM3 in astroglial endocytosis

Daisuke Ibi1, 2, Taku Nagai1, Toshitaka Nabeshima2, Kiyofumi Yamada1
1Dept. Neuropsychopharmacol. & Hosp. pharm., Nagoya Univ. Grad. Sch. Med., 2Dept. Chem. Pharmacol., Meijo Univ. Grad. Sch. of Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 231-231, 2012.

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P3-5-2 Ligands for toll-like receptors induce interferon-inducible transmembrane protein 3 through different intracellular signaling pathways in cultured astrocytes

Akira Nakajima1, Daisuke Ibi1, 2, Taku Nagai1, Toshitaka Nabeshima2, Kiyofumi Yamada1
1Dept. Neuropsychopharmacology and Hospital Pharmacy, Nagoya Univ. Grad. Sch. Med., 2Dept. Chemical Pharmacology, Meijo Univ. Grad. Sch. Pharmaceutocal. Sci.
Journal of Pharmacological Sciences 118 (suppl) 231-231, 2012.

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P3-5-3 Effect of dopaminergic drugs on learned helplessness and priming stimulation of intracranial self-stimulation behavior

Akihiko Nakamoto1, Satoru Esumi1, Hidenori Sagara2, Youichi Kawasaki1, Hisashi Matsunaga1, Toshiaki Sendo1
1Dept. Clin. Pharm., Dent. Pharmaceut. Sci., Okayama Univ. Sch. Med., 2Dept. Pharm. Info. Sci., Matsuyama Univ.
Journal of Pharmacological Sciences 118 (suppl) 231-231, 2012.

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P3-5-4 Hypofunction of dopamine D2 receptors in the nucleus accumbens of SHR, a rat model of attention deficit/hyperactive disorder (AD/HD)

Atsushi Masui1, Motoki Okano1, Mika Egawa1, Chikako Yoshihara1, Yuto Mizuguchi1, Shoko Minamimoto1, Ayaka Tatara1, Saki Shimizu1, Masashi Sasa2, Yukihiro Ohno1
1Lab. Pharmacol., Osaka Univ. Pharm. Sci., 2Ngisa Hospital
Journal of Pharmacological Sciences 118 (suppl) 231-231, 2012.

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P3-5-5 Tipepidine, centrally acting non-narcotic antitussive, has antipsychotic-like effect in mice

Risa Miki, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Environ. Mol. Health Sci., Grad Sch. Pharm. Sci., Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 232-232, 2012.

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P3-5-6 Measurement of kicking and biting responses toward touch stimuli for evaluation of irritability in isolated-reared mice.

Toshiko Kuchiiwa1, Osamu Murakami2, Satoshi Kuchiiwa3
1Dept. Clinical Psychol., Grad. Sch. Humansci., Kagoshima Imaculate Univ., 2Dept. Development, Muromachi Kikai Co.Ltd., 3Dept. Neuroanat., Grad. Sch. Med. Dent. Sci., Kagoshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 232-232, 2012.

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P3-5-7 Evaluation of N-methyl-D-asparate (NMDA) receptor antagonist-induced schizophrenia-like model in rats

Takashi Tashiro, Yoshiyuki Hayashida, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Pharmacology Efficacy Research Group, Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Corporation
Journal of Pharmacological Sciences 118 (suppl) 232-232, 2012.

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P3-5-8 IL1RAPU1 associated with mental retardation and autism induces excitatory synapse formation through trans-synaptic interaction with PTPδ

Tomoyuki Yoshida1, 2, Misato Yasumura1, Takeshi Uemura1, Sung-Jin Lee1, Moonjin Ra3, Ryo Taguchi3, Yoichiro Iwakura4, Masayoshi Mishina1
1Dept. Mol. Neurobiol. & Pharmacol., Grad. Sch. Med., Univ. of Tokyo, 2PRESTO, JST, 3Dept. Metabolome, Grad. Sch. Med., Univ. of Tokyo, 4Center for Exp. Med. & Syst. Biol., Inst. Med. Sci., Univ. of Tokyo
Journal of Pharmacological Sciences 118 (suppl) 232-232, 2012.

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P3-6-1 The mechanisms underlying the antidepressant effects of mGlu2/3 receptor antagonists

Hiroyuki Koike, Michihiko Iijima, Shigeyuki Chaki
Discov. Pharmacol. I, Mol. Func. Pharmacol. Labs., Taisho Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 233-233, 2012.

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P3-6-2 The acute and sustained effects of an mGlu5 receptor antagonist in the novelty-suppressed feeding test

Kenichi Fukumoto, Shigeyuki Chaki, Michihiko Iijima
Discov. Pharmacol. I, Mol. Func. Pharmacol. Labs., Taisho Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 233-233, 2012.

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P3-6-3 Neurochemical studies on the mechanism of a novel antidepressant like action of tipepidine in ACTH-treated rats.

Kazuaki Kawaura, Kei Hayasaki, Ryo Kawahara, Fumio Soeda, Tetsuya Shirasaki, Kazuo Takahama
Dept. Environ. Mol. Health. Sci. Grad. Sch., Kumamoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 233-233, 2012.

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P3-6-4 Antidepressant-like effects of glucagon-like peptide-2 in stress-vulnerable BALB/c mice

Sachie Hamada, Norihide Hayakawa, Jun-Ichiro Oka
Dept Pharmacol, Tokyo Univ. of Science
Journal of Pharmacological Sciences 118 (suppl) 233-233, 2012.

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P3-6-5 Antidepressant-like effects of the central antitussive dextromethorphan in mice

Yumi Sugimoto1, Katsumi Nishimura2, Takao Tanahashi2, Kumiko Saitoh3, Yoshihiro Hotta3, Jun Yamada1
1Lab. Pharmacol., Dept. Clin, Pharmacy, Yokohama Coll. Pharmacy, 2Dept. Orgnic Chem., Kobe Pharm. Univ, 3Coll. Pharma., Kinjo Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 234-234, 2012.

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P3-6-6 Sex differences in antidepresssant-like effects of fluvoxamine and paroxetine in mice

Yumi Sugimoto1, Noriko Tagawa2, Yoshiharu Kobayashi2, Kumiko Saitoh3, Yoshihiro Hotta3, Jun Yamada1
1Lab. Pharmacol., Dept. Clin. Pharmacy, Yokohama College of Pharmacy, 2Dept. Med, Biochem., Kobe Pharm. Univ., 3Coll. Pharm., Kinjo Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 234-234, 2012.

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P3-6-7 Effect of Fluvoxamine on Dexamethasone-continuous infusion mice

Kazuki Terada1, Biora Suzuki1, Norifumi Shimizu2, Michio Kimura3, Minehiro Moriyama4, Shigenori Watanabe2, Chiaki Hara2, Nobuo Izumo1
1Dept. Clin. Pharmacol., Yokohama Coll. Pharm., 2Dept. Pharmcol., Daiichi Univ. Col. of Pharmac. Sci., 3Dept. Microbiol. and Mol. Cell Biol., Nihon Pharmaceut. Univ., 4Dept. prescrip. analys., Daiichi Univ. Col. of Pharmac. Sci.
Journal of Pharmacological Sciences 118 (suppl) 234-234, 2012.

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P3-6-8 Sustained SSRI exposure induces augmentation of 5-HT release dependent on AMPA receptors in cultured serotonergic neurons

Kazuki Nagayasu, Hiroshi Fuketa, Maiko Kitaichi, Naoya Nishitani, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Dept. Molecular Pharmacology, Grad. Sch. Pharmac. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 234-234, 2012.

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P3-7-1 Effects of cannabinoid receptor agonists on the morphine-induced rewarding and dopamine release in NAcc

Tomoya Saeki1, Masahiro Shibasaki1, Tomohisa Mori1, Minako Abe1, Yuuya Udagawa1, Yasuhito Uezono2, Motohiro Matoba3, Tutomu Suzuki1
1Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Div. Cancer Pathophysiol., NCCRI, 3Dept. Palliative Med., NCCH
Journal of Pharmacological Sciences 118 (suppl) 235-235, 2012.

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P3-7-2 Studies on drug dependence (Rept. 459) Effects of chronic treatment of alcohol on the morphine-induced rewarding and antinociceptive effects

Tomohisa Tsuyuki, Masahiro Shibasaki, Kotaro Takeda, Tomohisa Mori, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 235-235, 2012.

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P3-7-3 Development of tolerance to antinociceptive effects induced by combination with morphine and cannabinoid receptor agonist

Masato Harumiya1, Tomohisa Mori1, Hiroshi Yoneyama1, Masahiro Shibasaki1, Tsutomu Suzuki1, Yasuhito Uezono2, Motohiro Matoba3
1Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 2Div. Cancer Pathophysiol., NCCRI, 3Dept. Palliative Med., NCCH
Journal of Pharmacological Sciences 118 (suppl) 235-235, 2012.

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P3-7-4 ProTxll, a selective Nav1.7 sodium channel inhibitor reverses hyperalgesia on mice model of diabetic neuropathy

Kenichiro Tanaka1, 2, Yuki Nakanishi1, Kimiko Maeda1, Megumi Asato1, Hiroko Ikeda1, Junzo Kamei1
1Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut., 2Dept. Endoclinol. Metab., Yokohama City Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 235-235, 2012.

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P3-7-5 Role of NF-кB on paclitaxel-induced neuropathic pain

Akane Sakai, Yuki Nakanishi, Megumi Asato, Hiroko Ikeda, Misa Kai, Junzo Kamei
Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut.
Journal of Pharmacological Sciences 118 (suppl) 236-236, 2012.

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P3-7-6 Changes in the expression of μ-opioid receptors and substance P in the dorsal root ganglia induced by peritoneal carcinomatosis in mice

Maho Ashikawa1, 2, Masami Suzuki1, Minoru Narita3, Minami Hasegawa2, Tsutomu Suzuki2, Motohiro Matoba4, Hiroki Sasaki5, Yasuhito Uezono1
1Div. Cancer Pathophysiol., NCCRI, 2Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 3Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci., 4Dept. Palliative Med., NCCH, 5Div. Genetics, NCCRI
Journal of Pharmacological Sciences 118 (suppl) 236-236, 2012.

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P3-7-7 Study on novel mechanism for TRPV1-mediated control of neuropathic pain

Takehiko Maeda1, Yuka Okada2, Shizuya Saika2, Siroh Kishioka3, Masanobu Ozaki4
1Dept. Pharmacol., Niigata Univ. Pharm. Appli Life Sci., 2Dept. Ophthalmol., Wakayama Med. Univ., 3Dept. Pharmacol., Wakayama Med. Univ., 4Dept. Toxicol., Niigata Univ. Pharm. Appli. Life Sci.
Journal of Pharmacological Sciences 118 (suppl) 236-236, 2012.

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P3-7-8 Antinociceptive effects of repetitive transcranial magnetic stimulation in mouse neuropathic pain model

Tomoaki Yuhi1, Yukiko Fueta2, Susumu Ueno3, Sadatoshi Tsuji1
1Dept Neurol, Univ of Occupation Environ Hlth, School of Med, 2Dept Hlth Manage, Univ of Occupation Environ Hlth, School of Hlth Sci, 3Dept. of Occupation. Toxiol., Institute of Indust. Ecolog. Sci., Univ. of Occupation. Environ. Hlth.
Journal of Pharmacological Sciences 118 (suppl) 236-236, 2012.

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P3-8-1 “salvia”：flower language is flare thought. (2)

Taizo Hayano1, Shiroh Kishioka2, Hiroyuki Yamamoto2
1Div. Psychiat. Wakaura Hosp., Asahikai-Wakaura Hops., 2Dept. Pharmacol. Wakayama Med. Sch., Med. Sch., Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 237-237, 2012.

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P3-8-2 Methamphetamine induces endoplasmic reticulum stress related gene CHOP/Gadd153/ddit3 in dopaminergic cells.

Yasuyuki Irie1, Makio Saeki2, Yukiko Kondo1, Yoshinori Kamisaki2, Eiichi Taira1
1Dept. Pharmacol., Iwate Medical Univ. Sch. Med., 2Dept. Pharmacol. Osaka Univ. Grad. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 237-237, 2012.

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P3-8-3 Extinction of Methamphetamine reward is facilitated by experience of running wheel in mice

Nobue Kitanaka1, Junichi Kitanaka1, Kaname Watabe2, Hitoshi Kubo2, Hitoshi Takahashi2, Koh-ichi Tanaka3, Nobuyoshi Nishiyama3, Motohiko Takemura1
1Dept. Pharmacol., Hyogo Col. Med., 2Muromachi Kikai, Co.,Ltd., 3Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci.
Journal of Pharmacological Sciences 118 (suppl) 237-237, 2012.

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P3-8-4 Isoliquiritigenin, a licorice flavonoid, blocks methamphetamine-induced locomotor hyperactivity in mice

Junichi Kitanaka1, Nobue Kitanaka1, Hiroki Minami1, Masayuki Okamoto1, Koh-ichi Tanaka2, Tomohiro Tatsuta3, Yoshio Morita4, Nobuyoshi Nishiyama2, Motohiko Takemura1
1Dept. Pharmacol., Hyogo Col. Med., 2Div. Pharmacol., Dept. Pharm.., Sch. Pharm., Hyogo Univ. Health Sci., Kobe, Hyogo, 3Ibogawa Hospital, 4Fac. Nursing, Baika Women's Univ.
Journal of Pharmacological Sciences 118 (suppl) 237-237, 2012.

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P3-8-5 The influence of chronic exposure to stress stimuli on the emotional state and the serum corticosterone level during ethanol withdrawal in mice

Hideaki Kato, Minoru Tsuji, Kazuya Miyagawa, Hiroshi Takeda
Div. Pharmacol., Sch. Pharm., Internat. Univ. Health and Welfare
Journal of Pharmacological Sciences 118 (suppl) 238-238, 2012.

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P3-8-6 Effect of tramadol on pain-related behaviors and bladder overactivity in rodent cystitis models

Takashi Homan, Junko Kyotani, Tatsuya Oyama
Discovery Research Laboratories, Nippon Shinyaku Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 238-238, 2012.

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P3-8-7 Tramadol activates urethral incontinence function through μ opioid receptors in rats

Tatsuya Oyama, Yuko Kawai, Michiko Oka
Discovery Research Laboratories, Nippon Shinyaku Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 238-238, 2012.

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P3-9-1 Aberrant TRPV1 expression in heat hyperalgesia associated with trigeminal neuropathic pain

Hiroko Urano1, Toshiaki Ara2, Yoshiaki Fujinami2
1Dept. Hard Tissue Research., Insti Oral Sci. Matsumoto Dent Univ., 2Dept. Pharmacol., Matsumoto Dent Univ.
Journal of Pharmacological Sciences 118 (suppl) 238-238, 2012.

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P3-9-2 Effect of Selective estrogen receptor modulators on catecholamine secretion in adrenal medullary cells

Hirohide Inagaki1, Yumiko Toyohira1, Takeshi Obara2, Toru Hachisuga3, Nobuyuki Yanagihara1
1Dept. Pharmacol., UOEH. Med., 2Dept. Anesth. UOEH. Med., 3Dept. Obst. & Gynecol., UOEH. Med.
Journal of Pharmacological Sciences 118 (suppl) 239-239, 2012.

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P3-9-3 Role of Kv3 potassium channels in endothelin-1-induced inhibition of noradrenaline release from the rat stomach

Kumiko Nakamura, Takahiro Shimizu, Kenjiro Tanaka, Kunihiko Yokotani
Dept. of Pnarmacol., Kochi Univ., Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 239-239, 2012.

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P3-9-4 Identification of oxygen sensitivity of TRPA1 channels using redox-sensitive chemical library

Shigeki Kiyonaka, Nobuaki Takahashi, Daisuke Kozai, Tomohiro Numata, Yusuke Mizuno, Jun-ichi Yoshida, Yasuo Mori
Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Eng., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 239-239, 2012.

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P3-9-5 Effects of anesthetic agents on renal sympathetic nerve activity in a freely moving conscious rat.

Yoshihide Fujisawa1, Naoki Kondo2, Yukiko Nagai1, Daisuke Nakano3, Akira Nishiyama3
1Life Sci. Res. Center, Kagawa Univ., 2Dept. Cardiorenal & Cerebrovasc. Medicine, Kagawa Univ. Sch. Med., 3Dept. Pharmacol., Kagawa Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 239-239, 2012.

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P3-9-6 Age-related changes in purinergic contraction and ATP release in rat urinary bladder

Tomoka Hosoda1, Yohei Abe1, Masato Nanri3, Yumi Katano2, Akira Ishihata2
1Grad. Sch. Med., Yamagata Univ. Sch. Med., 2Div. Theoretic. Nurse. & Pathophysiol., Yamagata Univ. Sch. Med., 3Div. Pharmacol., Taiho Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 240-240, 2012.

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P3-9-7 A ganglion stimulant, 1, 1dimethyl- 4phenylpiperazinium iodide (DMPP) stimulates both cholinergic and adrenergic neurons in isolated atrium of the mouse

Kenta Ochi1, Hiroki Teraoka1, Toshihiro Unno2, Sei-ichi Komori2, Masahisa Yamada3, Takio Kitazawa1
1Dept. Pharmacol., Sch. of Vet. Med., Rakuno Gakuen University, 2Lab. Pharmacol. Fac. Applied Biol. Sci. Gifu University, 3Okinawa Institute of Science and Technology
Journal of Pharmacological Sciences 118 (suppl) 240-240, 2012.

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P3-9-8 Effects of red wine flavonols on catecholamine secretion in cultured bovine adrenal medullary cells

Ruka Sakamaki1, Yumiko Toyohira2, Kenji Toyama1, Nobuyuki Yanagihara2
1Dept. Nutr. Sci., Univ. SJG., kokura, 2Dept. Pharmacol., Univ. Occup. & Environ. Hlth., Japn, Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 240-240, 2012.

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P3-9-9 Possible involvement of Nav1.7 sodium channels in cough reflex

Yuki Nakanishi, Tomoko Fujihira, Megumi Asato, Hiroko Ikeda, Junzo Kamei
Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 240-240, 2012.

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P3-10-1 Therapeutic effect of carvedilol on severe heart failure in a mouse model of dilated cardiomyopathy

Yutaka Kitamura, Sachio Morimoto, Lei Li, Miki Nonaka, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ
Journal of Pharmacological Sciences 118 (suppl) 241-241, 2012.

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P3-10-2 Therapeutic effect of pimobendan on end-stage heart failure in a mouse model of dilated cardiomyopathy

Miki Nonaka, Sachio Morimoto, Lei Li, Yutaka Kitamura, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 241-241, 2012.

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P3-10-3 Superoxide scavengers protect cardiac ischemia/reperfusion injury by inhibiting excessive norepinephrine overflow

Takeshi Koyama1, Masashi Tawa2, Akari Tsubota1, Noriko Yamagishi1, Tatsuya Sawano1
1Lab. Pathol. and Mol. Pharmacol., Osaka Univ. Pharmaceut, 2Dept. Pharmacol., Shiga Univl. Med. Sci.
Journal of Pharmacological Sciences 118 (suppl) 241-241, 2012.

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P3-10-4 The myocardial expression of tumor necrosis factor-stimulated gene-6 (TSG-6) increases at the end of inflammation in experimental autoimmune myocarditis (EAM).

Haruyo Kawaguchi, Tomomi Yamashita, Rie Torii, Hiroyuki Nakayama, Yasushi Fujio
Dept. Clin. Pharmacol. and Pharmacogenom., Osaka Univ. Pharma
Journal of Pharmacological Sciences 118 (suppl) 241-241, 2012.

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P3-10-5 Pathophysiological role of enhanced P2X receptor in animal models of dilated cardiomyopathy

Yuko Iwata, Shigeo Wakabayashi
Dept. Mol. Physiol. N.C.V.C.
Journal of Pharmacological Sciences 118 (suppl) 242-242, 2012.

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P3-10-6 Inotropic actions caused by muscarinic receptor subtypes in cardiac Purkinje fibers

Katsuharu Tsuchida1, Yumiko Mizukawa2, Tetsuro Urushidani2, Shigehiro Tachibana3, Yukiko Naito3
1Dept. Rational Med. Sci., Faculty Pharm. Sci., Doshisha Women's Coll., 2Dept. Pathophysiol., Faculty Pharm. Sci., Doshisha Women's Coll., 3Lab. Toxicol. Pharmacol., Hatano Res. Center, Food and Drug Safty Center
Journal of Pharmacological Sciences 118 (suppl) 242-242, 2012.

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P3-10-7 RNA aptamers against phospholamban with improved stability and efficacy

Yoshie Tanaka, Takeshi Honda, Hiroki Sakai, Makoto Inui
Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 242-242, 2012.

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P3-10-8 Carbamoyl-PROXYL-enhanced MRI detects very small disruptions in brain vascular permeability induced by dietary cholesterol in mice

Atuyuki Tomizawa1, Itsuko Ishii1, Rumiana Bakalova2, Zhivko Zhelev2, Ichio Aoki2, Mitsukazu Kitada3
1Dept. Clin. Pharmacol., Chiba Univ., 2Mol. Imaging Center, NIRS, 3Div. Pharmacy, Chiba Univ. Hospital
Journal of Pharmacological Sciences 118 (suppl) 242-242, 2012.

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P3-11-1 Prevention of endothelial dysfunction by nicorandil through reduction of oxidative stress in diabetic rats

Ken-ichi Serizawa, Kenji Yogo, Ken Aizawa, Yoshihito Tashiro, Nobuhiko Ishizuka
Pruduct Res. Dept., Chugai Pharmaceutical Co.,Ltd.
Journal of Pharmacological Sciences 118 (suppl) 243-243, 2012.

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P3-11-2 Erythropoietin inhibited NADPH oxidase-derived superoxide production, endothelial dysfunction and vascular inflammation in L-NAME-treated rat aorta

Maki Okabe, Hiroe Toba, Yushi Kojima, Tomohito Amano, Haduki Kasahara, Ryohei Nomura, Natsumi Yamaoka, Kazuki Noda, Jiahong Wang, Miyuki Kobara, Tetsuo Nakata
Dept. Clinical Pharmacology, Kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 243-243, 2012.

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P3-11-3 Telmisartan improved vascular dysfunction and inflammation via stimulation of peroxisome proliferator-activated receptor-γ in subtotal nephrectomized rat

Tadasuke Isohashi, Hiroe Toba, Chisato Tojo, Tatsuya Horikawa, Chika Hatanaka, Chika Katada, Jiahong Wang, Kazuki Noda, Miyuki Kobara, Tetsuo Nakata
Dept. Clinical Pharmacology, Kyoto Pharmaceutical Univ.
Journal of Pharmacological Sciences 118 (suppl) 243-243, 2012.

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P3-11-4 Effects of SP-8203, a Novel Neuroprotective Compound, Combined with Thrombolytic Therapy in a Rat Embolic Stroke Model

Yong Hyun Lee1, Chul Kyu Lee1, 3, Il Hwan Cho1, Ryu Jei Man1, Eun Bang Lee2
1Central Research Institute, Shin Poong Pharmaceutical Company. Ltd, 2College of Pharmacy, Seoul National University, 3School of Pharmacy, Sungkyunkwan University
Journal of Pharmacological Sciences 118 (suppl) 243-243, 2012.

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P3-11-5 Interleukin-11 Attenuates Infarct Size And Improves Ventricular Function In a Canine Heart Model Of Ischemia/Reperfusion Injury

Makiko Maeda1, Koji Takeda2, Goro Matsumiya3, Junichi Azuma1, Yasushi Fujio2, 4
1Hyogo Univ. of Health Sciences, 2Osaka Univ. Sch. Med., 3Chiba Univ. Sch. Med., 4Osaka Univ. Sch. Pharmaceutical Sciences
Journal of Pharmacological Sciences 118 (suppl) 244-244, 2012.

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P3-11-6 HCM-linked troponin I mutation D127Y increases the cardiac myofilament Ca2+ sensitivity in a manner dependent on Ser23/24 phosphorylation

Qun-Wei Lu1, Sachio Morimoto2, Lei Li2, Jie Li1, Toshiyuki Sasaguri2
1Key Lab. Mol. Biophys. Huazhong Univ. Sci. Tech., 2Dept. Clin. Pharmacol., Kyushu Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 244-244, 2012.

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P3-11-7 Involvement of lysophosphatidic acid in neointimal thickening in rat injured artery

Ken Ishido1, Junko Nakamoto1, Chika Asagi2, Akira Tokumura2, Naoshi Yamazaki3, Yoshiharu Takiguchi3
1Dept. Clin. Pharmacol, Facl. Pharmaceu. Sci., Tokushima Univ., 2Dept. Pharm. Health Chem., Inst. Health Biosci.. Tokushima Univ. Grd. Sch., 3Dept. Clin. Pharmacol., Inst. Health Biosci., Tokushima Univ. Grd. Sch.
Journal of Pharmacological Sciences 118 (suppl) 244-244, 2012.

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P3-11-8 Mechanisms of AZT-induced mitochondrial dysfunstion

Ryosuke Nomura1, Shigeki Kushimoto1, Teruyuki Yanagisawa2, Takeya Sato2
1Emergency Center, Tohoku Univ. Hosp., 2dept. molpharm., Tohoku Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 244-244, 2012.

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P3-11-9 The effect of Br-DIF-1 on 1% dimethyl sulfoxide-induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells

Kazuhiko Seya1, Kouta Kanemaru1, Mizuho Matsuki2, Kyoko Hongo1, Haruo Kitahara2, Haruhisa Kikuchi3, Yoshiteru Oshima3, Yuzuru Kubohara4, Ken Okumura5, Shigeru Motomura1, Ken-Ichi Furukawa1
1Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med., 2Fac. Edu., Hirosaki Univ., 3Grad. Sch. Pharmaceut. Sci., Tohoku Univ., 4Dept. Mol. Cell. Biol., Inst. Mol. Cell. Regul., Gunma Univ., 5Dept. Cardiol. Respir. Med. Nephrol., Hirosaki Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 245-245, 2012.

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P3-12-1 Rho kinase-mediated di-phosphorylation of myosin light chain in the subjunctional regions Plays a critical role in thrombin-induced endothelial barrier dysfunction

Mayumi Hirano, Akiko Hanada, Katsuya Hirano
Div. Mol. Cardiol., Grad. Sch. Med. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 245-245, 2012.

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P3-12-2 L-Citrulline dilates retinal blood vessels in rats

Asami Mori1, Toshiaki Takei1, Masahiko Morita2, Satoshi Nakagawa2, Kenji Sakamoto1, Tsutomu Nakahara1, Kunio Ishii1
1Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci., 2Healthcare products development center, KYOWA HAKKO BIO CO.,LTD.
Journal of Pharmacological Sciences 118 (suppl) 245-245, 2012.

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P3-12-3 Role of cyclooxygenase-2 in enhancement of during wound healing and lymphangiogenesis

Kanako Hosono1, 2, Tatsunori Suzuki1, 2, Shuh Narumiya3, Masataka Majima1, 2
1Dept. Pharmacol., Kitasato Univ. Sch. Med., 2Dept. Mol. Pharmacol., Grad. Sch. Med., 3Dept. Pharmacol., Kyoto Univ. Fac. Med.
Journal of Pharmacological Sciences 118 (suppl) 245-245, 2012.

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P3-12-4 Role of metallothionein-1 and - 2 in the ocular neovascularization

Shinsuke Nakamura1, Shinsuke Takata1, Yasushi Ito1, Hiromi Ogishima1, Kazuhiro Tsuruma1, Masamitsu Shimazawa1, Tsunehiko Ikeda2, Akiko Honda3, Masahiko Satoh3, Hideaki Hara1
1Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ., 2Depart. of Ophthal., Osaka Med. Col., 3Lab. of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin Univ.
Journal of Pharmacological Sciences 118 (suppl) 246-246, 2012.

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P3-12-5 Reactive α-dicarbonyl compounds enhance bisphosphonate-induced endothelial injury.

Masamichi Tajima, Hiroshi Sakagami
Div. Pharmacol., Dept. Diagnostic and Therapeutic Sciences, Meikai Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 246-246, 2012.

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P3-12-6 ADP receptor-mediated differentiation of bone-marrow-derived cells into smooth muscle-like cells

Yuji Matsumoto, Kosuke Harada, Kazuo Umemura
Dept. Pharmacol., Hamamatsu Univ. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 246-246, 2012.

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P3-12-7 Effects of nicotine on vascular smooth muscle cells migration and gene expression.

Shinji Yoshiyama, Kazuhiro Kohama, Akio Nakamura
Dept. Mol. Cell. Pharmacol., Gunma Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 246-246, 2012.

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P3-12-8 Role of TRPC6 channel in peripheral circulatory disturbance

Shota Saiki1, Masaaki Sumita1, Yoji Sato2, Michio Nakaya1, Takahiro Iwamoto3, Hitoshi Kurose1, Motohiro Nishida1
1Dept. of Pharmacol. & Toxicol., Grad. Sch. of Pharm. Sci, Kyushu Univ., 2Div. of Cell. & Gene Therap. Prod., Natl. Inst. of Health Sci., 3Dept. of Pharmacol., Facul. Med., Fukuoka Univ.
Journal of Pharmacological Sciences 118 (suppl) 247-247, 2012.

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P3-12-9 Chronic constriction of sciatic nerve enhances sensitivity to contractile stimuli in rat planter artery

Takuma Hurukawa, Shin-ya Saito, Tomohisa Ishikawa
Dept. Pharmacol., Univ. Shizuoka Sch. Pharm.
Journal of Pharmacological Sciences 118 (suppl) 247-247, 2012.

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P3-13-1 The increased protein level of renal urate transporter Urat1 was observed in obesity/metabolic syndrome model mice.

Makoto Hosoyamada, Masaru Doshi
Physiol. Chem., Teikyo Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 247-247, 2012.

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P3-13-2 Protective effect of dietary iron restriction on diabetic nephropathy

Hideaki Enomoto1, 2, Yasumasa Ikeda1, Soichiro Tajima1, Yuki Ishizawa1, Yoshitaka Kihira1, Keisuke Ishizawa3, Shuhei Tomita1, Koichiro Tsuchiya3, Toshiaki Tamaki1
1Dept. Pharmacology, The Univ. Tokushima Grad. Sch., 2Student Laboratory, Univ. Tokushima Faculty Med., 3Dept. Med Pharma, The Univ. Tokushima Grad. Sch.
Journal of Pharmacological Sciences 118 (suppl) 247-247, 2012.

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P3-13-3 Nicorandil protects proteinuria without lowering blood pressure in Dahl salt-sensitive hypertensive rats

Yoshihito Tashiro, Ken-ichi Serizawa, Keigo Yorozu, Nobuhiko Ishizuka, Kenji Yogo
Product Research Dept., Chugai Pharmaceutical Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 248-248, 2012.

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P3-13-4 Systematic evaluation of GABA receptor subtype and subunit mRNAs in renal cortex of hypertensive model rats.

Kozue Takano1, Junichi Yatabe1, 2, Midori Yatabe1, Hironobu Sanada3, Tsuyoshi Watanabe2, Junko Kimura1
1Dept. Pharmacol., Fukushima Med. Univ. Sch. Med., 2Dept. Nephrol., Hypertens., Diabetol., Endo. and Metab., Fukushima Med. Univ. Sch. Med., 3Div. of HSR, Fukushima Welfare Federation of Agricultural Coop.
Journal of Pharmacological Sciences 118 (suppl) 248-248, 2012.

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P3-13-5 Hypertensive animal model and dietary salt loading alter urinary amino acid patterns

Junichi Yatabe1, 2, Midori Yatabe1, Kozue Takano1, Hironobu Sanada3, Tsuyoshi Watanabe2, Toshihiko Ando4, Junko Kimura1
1Dept. Pharmacol., Fukushima Med. Univ. Sch. Med., 2Dept. Nephrol., Hypertens., Diabetol., Endo. and Metab., Fukushima Med. Univ. Sch. Med., 3Div. of HSR, Fukushima Welfare Federation of Agricultural Coop., 4AminoIndex Dept., Ajinomoto Co., Inc.
Journal of Pharmacological Sciences 118 (suppl) 248-248, 2012.

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P3-13-6 Osmotic regulation of Osp94, a hypertoic stress sensitive molecular chaperone, in renal medulla and macula densa

Ryoji Kojima, Mai Taga, Mikio Ito
Lab. Anal. Pharmacol., Fac. Pharm., Meijo Univ.
Journal of Pharmacological Sciences 118 (suppl) 248-248, 2012.

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P3-13-7 Comparison of HPLC and GCMS methods for determination of morphine in human urine

A. B. Ruzilawati, A. L. Nor Suziana, G. R. Aida Hanum, W. Y. Wan Nazirah, R. Norzihana
Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia
Journal of Pharmacological Sciences 118 (suppl) 249-249, 2012.

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P3-14-1 Autophagic-lysosomal pathway contributes to the sarcopenia of masseter and tongue muscles in the klotho mouse

Akira Yamane1, Ryohei Iida2, Shuhei Kaneko2, Takeo Suga2, Mitsuhiko Morito2
1Dept. Byophysics, Tsurumi Univ. Sch. Dent. Med., 2Dept. Geriatric., Tsurumi Univ. Sch. Dent. Med.
Journal of Pharmacological Sciences 118 (suppl) 249-249, 2012.

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P3-14-2 The conflicting effects of eugenol on TRPV1 channel.

Takashi Yoshida1, Takashi Kikuchi1, Kaori Takahashi2, Minoru Wakamori1
1Div. Mol. Pharmacol. and Cell Biophys., Dept. Oral. Biol. Tohoku univ. Grad. Sch. Dent., 2Tohoku univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 249-249, 2012.

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P3-14-3 Expression and role of aquaporin 5 and aquaporin 3 in various types of oral cancers

Shunsuke Ishimoto1, 2, Koichiro Wada1, Masaya Okura2, Mikihiko Kogo2, Yoshinori Kamisaki1
1Dept. Pharmacol., Osaka Univ. Grad. Sch. Dent., 21st Dept. Oral and Maxillofacial Surg., Osaka Univ. Grad. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 249-249, 2012.

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P3-14-4 Establishment of rat submandibular gland perfusion method for drug induced xerostomia

Migiwa Okubo, Takashi Shinomiya, Eri Tsukagoshi, Kouhei Sawaki, Mitsuru Kawaguchi
Dept. Pharmacol., Tokyo Dent. col.
Journal of Pharmacological Sciences 118 (suppl) 250-250, 2012.

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P3-14-5 Virulence and antifungal drug sensitivity of Candida albicans isolated from Oral Candidasis patients (The comparison of Erythematous and Hyperplastic Oral Candidasis)

Tomohiro Nagayama1, Yoshiaki Kamikawa2, Daisuke Hirabayasi2, Juniti Fuzisaki2, Tomoaki Sato1, Kazumasa Sugihara2
1Dept. Appl. Pharmacol., Grad. Sch. Med. Dent. Sci. Kagoshima Univ., 2Dept. Maxillofac. Diag. Surg. Sci. Grad. Sch. Med. Dent. Sci. Kagoshima Univ.
Journal of Pharmacological Sciences 118 (suppl) 250-250, 2012.

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P3-14-6 Diazepam enhances expression of PAC1-R and CYP11A1 in rat salivary glands

Eri Tsukagoshi1, Takashi Shinomiya1, Masanobu Yoshikawa1, 2, Migiwa Okubo1, Kohei Sawaki1, Mitsuru Kawaguchi1
1Dent. Pharmacol., Tokyo Dent. Coll., 2Dept. of Clin. Pharmacol., Tokai Univ. Sch. of Med.
Journal of Pharmacological Sciences 118 (suppl) 250-250, 2012.

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P3-14-7 Phenytoin-induced elevation of intracellular calcium concentration in gingival fibroblasts

Toshimi Hattori, Toshiaki Ara, Yoshiaki Fujinami
Dept. Dent. Pharmacol., Matsumoto Dent. Univ.
Journal of Pharmacological Sciences 118 (suppl) 250-250, 2012.

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P3-14-8 Gene expression profile of dental pulp cells during differentiation into an adipocyte lineage

Tadashige Nozaki, Kiyoshi Ohura
Dept. Pharmacol., Osaka Dent. Univ.
Journal of Pharmacological Sciences 118 (suppl) 251-251, 2012.

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P3-14-9 Association of the cell migration and invasion with matrix metalloproatease-9 in oral squamous cell carcinomas

Tomohiro Ono, Shinichi Iwai, Shunya Egawa, Takehiko Sambe, Katsuji Oguchi
Dept. Pharmacol., Showa Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 251-251, 2012.

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P3-15-1 Bioluminescence imaging of Arc expression in response to acute exposure to pesticides

Hironori Izumi1, 2, Tetsuya Ishimoto1, Miki Shoji2, Hisashi Mori1
1Dept. Mol. Neurosci., Univ. of Toyama, 2Life Sci. Res. Ctr., Univ. of Toyama
Journal of Pharmacological Sciences 118 (suppl) 251-251, 2012.

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P3-15-2 In vitro dephosphorylation assay for endogenously expressing GABAB receptor proteins

Yukari Saito, Machiko Ito, Kiyokazu Ogita, Nobuyuki Kuramoto
Dept. of Pharmacol., Setsunan Univ.
Journal of Pharmacological Sciences 118 (suppl) 251-251, 2012.

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P3-15-3 Development of 18F-Labeled PET Probes for Imaging Neuropathology of Alzheimer's Disease

Shozo Furumoto1, 2, Nobuyuki Okamura1, Makoto Higuchi3, Ren Iwata2, Yukitsuka Kudo4, Kazuhiko Yanai1, 2
1Dept. Pharmacol., Tohoku Univ. Sch. Med., 2Tohoku Univ., CYRIC, 3National Inst. Radiol. Sci., Mol. Imaging Center, 4Tohoku Univ., Innovation New Biomed., Engin. Center
Journal of Pharmacological Sciences 118 (suppl) 252-252, 2012.

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P3-15-4 In vivo evaluation of sedative properties of levocetirizine by small animal PET/CT

Tomomitsu Iida1, Yoshihito Funaki1, Kiichi Ishiwata3, Fumito Naganuma2, Ryuichi Harada2, Ren Iwata1, Kazuhiko Yanai2
1Cyclotron and RI Center., Tohoku Univ. Sch. Pharm., 2Dept. Pharmacol., Tohoku Univ. Sch. Med., 3Tokyo Metropolitan Institute of Gerontology
Journal of Pharmacological Sciences 118 (suppl) 252-252, 2012.

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P3-15-5 The culture medium for maintaining CYP 3A4 and drug transporters activities in primary cultured human hepatocytes

Yuko Takeba1, Sachiko Takenoshita-Nakaya1, Yuki Ohta1, Minoru Watanabe2, Naoki Matsumoto1
1Dept. Pharmacol., St. Marianna Univ. Sch. Med., 2Institution of Animal Experimentation, St. Marianna Univity Graduate School of Medicine
Journal of Pharmacological Sciences 118 (suppl) 252-252, 2012.

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P3-15-6 Application of a novel electrophysiological assay technique to native lysosomal membranes

Yu Sakamoto1, Hisashi Shirakawa2, Takayuki Nakagawa2, Shuji Kaneko2
1Dept. Mol. Pharmacol., Fac. Pharm. Sci., Kyoto Univ., 2Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 252-252, 2012.

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P3-15-7 Comprehensive and comparative quantification of epithelial cell membrane transporters between wild type and diabetic model mice

Shushi Nagamori, Kazuaki Takafuji, Takashi Nishiyama, Yoshikatsu Kanai
Dept. Pharmacol., Osaka Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 253-253, 2012.

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P3-16-1 Functional role of a vesicular ATP transporter, VNUT, mediating ATP release in normal human epidermal keratinocytes

Kaori Inoue1, Kayoko Fujishita2, Keisuke Shibata2, Ryohei Komatsu2, Yoshio Imura2, Yoshinori Moriyama3, Schuichi Koizumi2
1Shiseido Research Center, 2Dept. Neuropharmacol., Interdisciplinary Grad. Sch., Med and Engineering, Univ Yamanashi, 3Dept. Membrane Biochemistry, Okayama Univ. Grad. Sch., Med. Den. Pharmaceut. Sci.
Journal of Pharmacological Sciences 118 (suppl) 253-253, 2012.

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P3-16-2 Promotion of skin epithelial single cell migration by SSSR, a tetrapeptide derived from the C domain of IGF-1

Hiroki Sakai, Kenji Matsuura, Makoto Inui
Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 253-253, 2012.

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P3-16-3 Regulation of adipocyte differentiation by PDZRN3 protein

Takeshi Honda, Aiko Ishii, Makoto Inui
Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 253-253, 2012.

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P3-16-4 Roles of GPR55 in 3T3-L1 preadipocytes

Nakaba Kobayashi, Kouichiro Mori, Yutaro Obara, Norimichi Nakahata
Dept. Cell. Signal, Grad. Sch. Pharmaceut. Sci., Tohoku Univ.
Journal of Pharmacological Sciences 118 (suppl) 254-254, 2012.

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P3-16-5 Fatty acid compositions and thermogenesis in brown adipose tissue after dietary intervention of three kinds of high-fat diets

Eri Yamada1, Kazuyo Yamada1, Hiromi Tsushima1, Daisuke Miyazawa1, Mayumi Mori2, Takeshi Ohkubo3, Hidehiko Hibino3, Harumi Okuyama1
1College of Pharm., Kinjo Gakuin Univ., 2Dept. of Pharmacol., Nagoya City Univ., 3NOF Corporation
Journal of Pharmacological Sciences 118 (suppl) 254-254, 2012.

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P3-16-6 HIS-388, a potent orally active 11beta-hydroxysteroid dehydrogenase type1 inhibitor, improves insulin resistance and glucose intolerance in obese and diabetes model mice.

Seiji Okazaki, Tomokatsu Iwamura, Takehiro Takahashi, Junko Nakaki, Yumiko Sekiya, Hiroki Kumagai, Satoshi Sakami, Aiko Nitta, Koji Kawai, Mie Kainoh
Pharmaceutical Research Laboratories, Toray Industries, Inc.
Journal of Pharmacological Sciences 118 (suppl) 254-254, 2012.

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P3-16-7 A novel PPARγ partial agonist KY-903 (1) ： Anti-diabetic effects and safety in KK-Ay mice

Masaki Fukui, Kazuyoshi Kunishiro, Mamoru Kanda, Masahiro Kubo, Hikaru Kamemoto, Daisuke Yamauchi, Hiroaki Shirahase
Research Laboratories, Kyoto Pharmaceutical Industries, Ltd.
Journal of Pharmacological Sciences 118 (suppl) 254-254, 2012.

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P3-16-8 A novel PPARγ partial agonist KY-903 (2) ： Insulin resistance improving effects and safety in Zucker fatty rats

Masahiro Kubo, Masaki Fukui, Hikaru Kamemoto, Kazuyoshi Kunishiro, Mamoru Kanda, Daisuke Yamauchi, Hiroaki Shirahase
Research Laboratories, Kyoto Pharmaceutical Industries, Ltd.
Journal of Pharmacological Sciences 118 (suppl) 255-255, 2012.

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P3-16-9 A novel PPARγ partial agonist KY-903 (3) ： Effects on ovariectomy rats fed a high fat diet

Hikaru Kamemoto, Masahiro Kubo, Masaki Fukui, Kazuyoshi Kunishiro, Mamoru Kanda, Daisuke Yamauchi, Hiroaki Shirahase
Research Laboratories, Kyoto Pharmaceutical Industries, Ltd.
Journal of Pharmacological Sciences 118 (suppl) 255-255, 2012.

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P3-17-1 The role of diacylglycerol kinase in histamine release

Megumi Sakuma1, Yasuhito Shirai2, Takehiko Ueyama1, Naoaki Saito1
1Lab. of Mol. Pharmacol., Biosignal. Res. Ctr., Kobe Univ., 2Grad. Sch. of Agricultural Sci., Kobe Univ.
Journal of Pharmacological Sciences 118 (suppl) 255-255, 2012.

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P3-17-2 The affinity of histamine for histamine H1 receptors is predominantly regulated by their GRK/clathrin-mediated internalization in human astrocytoma cells

Chizuru Akatsu, Shigeru Hishinuma, Yuko Sato, Masaru Shoji
Dept. Pharmacodyn., Meiji Pharm. Univ.
Journal of Pharmacological Sciences 118 (suppl) 255-255, 2012.

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P3-17-3 Thermodynamic binding properties of agonists and antagonists at human histamine H1-receptors in Chinese hamster ovary cells

Kenta Sugawara1, Shigeru Hishinuma1, Hiroyuki Fukui2, Masaru Shoji1
1Dept. Pharmacodyn., Meiji Pharm. Univ., 2Dept. Mol. Pharmacol., Grad. Sch. Health Biosci., Univ. Tokushima
Journal of Pharmacological Sciences 118 (suppl) 256-256, 2012.

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P3-17-4 Accumulation of NADPH oxidase (NOX2) and increased oxidative stress in cathepsin E-deficient macrophages

Takayuki Tsukuba1, Tomoko Kadowaki2, Kuniaki Okamoto1, Kenji Yamamoto3
1Dept. Oral Pathopharmacol., Nagasaki Univ. Grad. Sch. Biomed, Sci., 2Dept. Microbiol., Nagasaki Univ. Grad. Sch. Biomed, Sci., 3Proteolysis Res. Lab. Grad. Sch Pharmaceu. Sci, Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 256-256, 2012.

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P3-17-5 Reaction of shikonin with superoxide anion

Lucia Satiko Yoshida1, Shunji Kohri2, Hirotada Fujii2, Shohko Tsunawaki3, Taizo Taniguchi4, Hiromi Takano-Ohmuro1
1Res. Inst. Pharmac. Sci., Musashino Univ., 2Cent. Med. Edu., Sapporo Med. Univ., 3Dept. of Anatomy, Showa Univ. School Med., 4Fac. Pharm. Sci., Himeji Dokkyo Univ.
Journal of Pharmacological Sciences 118 (suppl) 256-256, 2012.

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P3-17-6 Cytotoxic effects of nicotine/tar-free cigarette smoke extract (CSE)： Involvement of reactive oxygen species newly generated by PKC-dependent activation of NADPH oxidase.

Yosuke Mai1, Takahiro Horinouchi1, Hiroshi Asano1, Osamu Sawada1, Tadashi Nishiya1, Masabumi Minami2, Takahiro Katayama2, Koji Terada1, Soichi Miwa1
1Dept. Cell. Pharmacol., Grad. Sch. Med., Hokkaido Univ., 2Dept. Pharmacol., Grad. Sch. Pharmaceut. Sci., Hokkaido Univ.
Journal of Pharmacological Sciences 118 (suppl) 256-256, 2012.

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P3-17-7 A novel calmodulin-dependent protein, eEF2K mediates inflammation in vascular endothelial cells

Tatsuya Usui, Muneyoshi Okada, Yukio Hara, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Kitasato Univ. Sch. Vet. Med. Sci.
Journal of Pharmacological Sciences 118 (suppl) 257-257, 2012.

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P3-17-8 Reciprocal roles of S1P on expression of αSMA in TGF-β1-stimulates HFL1 cells

Risa Yamazaki1, 2, Yasuo Matsuzawa2, Tatsuo Kawashima2, Sho Otake1, Mamoru Takabatake1, Hiroyuki Nakamura1, Hiromichi Fujino1, Toshihiko Murayama1
1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 2Department of Internal Medicine, Toho University School of Medicine, Sakura Hospital
Journal of Pharmacological Sciences 118 (suppl) 257-257, 2012.

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P3-17-9 Indomethacin reduces prostaglandin E2-stimulated cyclic AMP formation： a cyclooxygenase inhibition-independent effect.

Yuta Ikawa, Hiromichi Fujino, Toshihiko Murayama
Lab. Chemical Pharmacol., Grad. Sch. Pharm. Sci. Chiba Univ.
Journal of Pharmacological Sciences 118 (suppl) 257-257, 2012.

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P3-18-1 Establishment of allergic dermatitis model using Gottingen minipigs

Yukari Matsui, Yasushi Hirasawa, Katsuhiro Higuchi, Masato Kakishima, Kenji Horinouchi, Kazuyoshi Naito
Nihon Bioresearch Inc.
Journal of Pharmacological Sciences 118 (suppl) 257-257, 2012.

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P3-18-2 Production of AGE subspecies-specific monoclonal antibodies in rats

Yuta Morioka1, Yasuko Tomono2, Hidenori Wake1, Keyue Liu1, Kiyoshi Teshigawara1, Hideo Takahashi3, Shuuji Mori4, Masahiro Nishibori1
1Dept. Pharmacol., Okayama Univ. Sch. Med, 2Shigei Res. Med, 3Kinki Univ, 4Shujitsu Univ.
Journal of Pharmacological Sciences 118 (suppl) 258-258, 2012.

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P3-18-3 The intake of Advanced Glycation End products (AGEs) in macrophage

Jingxiu Zhou1, 2, Megumi Shibuya1, Hidenori Wake1, Keyue Liu1, Yuuta Morioka1, Mai Okamura1, Syuji Mori2, Masahiro Nicibori1
1Dept. Pharmacol., Okayama Univ. Sch. Med, 2Shujitsu Univ.
Journal of Pharmacological Sciences 118 (suppl) 258-258, 2012.

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P3-18-4 Partial purification and characterization of a glycoprotein from the coelomic fluid of the sea urchin, Toxopneustes pileolus

Hideyuki Nakagawa1, Jun Kurochi1, Kozue Edo2, Yuika Watanabe1, Hitomi Sakai1, Ayaka Miki1, Shun Morikawa1, Takanori Satoh1, Mitsuko Shinohara3, Kiyoshi Ohura3
1Dept. of Environmental Symbiosis, Inst. of Scio-Arts and Sci., Univ. of Tokushima Grad. Sch., 2Dept. of Nutritional Sci., Univ. of Yasuda Women's, 3Dept. of Pharmacol., Osaka Dental Univ.
Journal of Pharmacological Sciences 118 (suppl) 258-258, 2012.

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P3-18-5 Comprehensive analysis of molecules involved in CLP-induced sepsis model/Investigation with p38-knockout mice

Kent Yoshioka1, Kensuke Tanaka1, 2, Tatsuhiko Sudou3, Takeshi Kobayashi1, 2, Hiroyuki Amano1, 2, Sadao Kimura1, Yoshitoshi Kasuya1
1Dept. of Biochem. and Mol. Pharmacol., Grad. School of Med. Chiba Univ., 2Dept. of Respirol., Grad. School of Med., Chiba Univ., 3Dept. of Antibiotics, RIKEN
Journal of Pharmacological Sciences 118 (suppl) 258-258, 2012.

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P3-18-6 Generation of Histidine Decarboxylase (HDC) reporter mouse using bacterial artificial chromosome (BAC).

Atsushi Sato, Hiroshi Ohtsu
Applied Quantum Medical Engineering, Tohoku Univ.
Journal of Pharmacological Sciences 118 (suppl) 259-259, 2012.

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P3-18-7 Investigation of the measurement method of GLP-1 in rat

Shinichi Ozato1, Tsutomu Hashimoto2, Seiichi Katayama1, Hiroshi Atai1, Katsuhide Nishi1
1Pharmacology Efficacy Reseach Group, Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Cemical Medience Corporation, 2Advanced Medical Science Research Center, Drug Development Service Segment, Mitsubishi Cemical Medience Corporation
Journal of Pharmacological Sciences 118 (suppl) 259-259, 2012.

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P3-18-8 G protein-coupled receptor kinase 6 (GRK6) mediates the engulfment of apoptotic cells

Mitsuru Tajima, Michio Nakaya, Mina Ohba, Akiko Hashimoto, Motohiro Nishida, Hitoshi Kurose
Dept. Pharmacol, & Toxicol., Grad. Sch. of Pharm. Sci., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 259-259, 2012.

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P3-18-9 Identification of two transcrips and in vivo promoter analysis for cathepsin E

Kuniaki Okamoto1, Yoshiko Okamoto2, Eiko Sakai1, Kazuhisa Nishishita1, Kenji Yamamoto3, Takayuki Tsukuba1
1Dept. Oral Pathopharmacol., Biomed Sci., Grad. Sch., Nagasaki Univ, 2Dept. Biochemistry, Daiichi college of Pharmaceutical Sci., 3Dept. Proteolysis Res. Lab., Pharmaceu. Sci., Grad. Sch., Kyushu Univ.
Journal of Pharmacological Sciences 118 (suppl) 259-259, 2012.

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P3-19-1 Development of a mouse model for oral mucositis induced by radiation

Noriko Nakajima1, Kenshi Takechi2, Shinichi Watanabe2, Katsuya Suemaru1, 2, Hiroaki Araki1, 2
1Dept. Clinical Pharmacol. Pharmacy, Ehime Univ. Sch. Med., 2Div. Pharmacy, Ehime Univ Hp
Journal of Pharmacological Sciences 118 (suppl) 260-260, 2012.

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P3-19-2 Examination of curative effects of herbal medicines on frequent urination in the over active bladder (OAB) model in aging rats

Ryoji Mizumachi, Hiroaki Fukuda, Emi Morita, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Pharmacology Department, Nonclinical Research Center Drug Development Service Segment, MITSUBISHI CHEMICAL MEDIENCE CORPORATION
Journal of Pharmacological Sciences 118 (suppl) 260-260, 2012.

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P3-19-3 Alteration of urodynamic parameters and up-regularion of muscarinic and purinergic receptors in the fructose-fed rat

Yoshihiko Ito, Nozomi Kojima, Akira Yoshida, Shizuo Yamada
Dept. of Phamacokinet. and Pharmacodyn., Sch. Pharm. Sci., Univ. Shizuoka
Journal of Pharmacological Sciences 118 (suppl) 260-260, 2012.

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P3-19-4 Investigation of the post-exercise renal damage with reactive oxygen

Yuki Furubayashi, Chie Yamaura, Masaki Tobita, Makiko Nakamura, Kimiyoshi Ichida
Dept. Pathophysiol., Tokyo Univ. Pharm. Life Sci.
Journal of Pharmacological Sciences 118 (suppl) 260-260, 2012.

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P3-19-5 The usefulness of urinary lipocalin 2 in the detection of drug-induced renal disorder

Yoko Fujiwara, Hiroyoshi Tsuchiya, Jun-ichi Taniguchi, Akio Fujimura, Taka-aki Koshimizu
Div. of Mol. Pharmacol., Dep. of Pharmacol., Jichi Med. Univ.
Journal of Pharmacological Sciences 118 (suppl) 261-261, 2012.

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P3-19-6 Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease

Masashi Asai1, 2, 3, 4, Naoki Yahata4, 5, Kei Maruyama1, Takaomi Saido2, Nobuhisa Iwata2, 3, 4, Haruhisa Inoue4, 5
1Dept. of Pharmacol., Fac. of Med., Saitama Med. Univ., 2Lab. for Proteolytic Neurosci., RIKEN, Brain Sci. Inst., 3Div. of Biotechnol., Dept. of Mol. Med. Sci., Grad. Sch. of Biomed. Sci., Nagasaki Univ., 4CREST, JST, 5CiRA, Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 261-261, 2012.

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P3-19-7 Elevation of dopamine D1receptor-mediated neurotransmission in the nucleus accumbens core region of SHR, a rat model of attention deficit/hyperactive disorder (AD/HD)

Yuto Mizuguchi1, Motoki Okano1, Atsushi Masui1, Mika Egawa1, Chikako Yoshihara1, Shoko Minamimoto1, Ayaka Tatara1, Junta Imaki1, Saki Shimizu1, Masashi Sasa2, Yukihiro Ohno1
1Lab. Pharmacol., Osaka Univ. Pharm. Sci, 2Nagisa Hospital
Journal of Pharmacological Sciences 118 (suppl) 261-261, 2012.

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P3-19-1 Characterization of noradrenergic activity in the lateral hypothalamic area of heterozygous Mecp2+/-female mouse

Hatakazu Takiguchi, Tadashi Saigusa2, Yuri Aono2, Noriaki Koshikawa2, Tetsuo Shirakawa1
1Dept. Ped. Dent., Nihon Univ. Sch. Dent., 2Dept. Pharmacol., Nihon Univ. Sch. Dent.
Journal of Pharmacological Sciences 118 (suppl) 261-261, 2012.

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P3-19-9 Training promotes functional recovery following spinal injury in medaka fish.

Takashi Kawasaki, Tomonori Deguchi, Shunsuke Yuba
HRI, AIST
Journal of Pharmacological Sciences 118 (suppl) 262-262, 2012.

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P3-20-1 GREEN TEA CATECHINS AFFECT PHARMACOKINETICS OF NADOLOL IN RATS

Nozomu Miyazaki1, Shingen Misaka1, Keisuke Kawabe2, Shizuo Yamada2, Junko Kimura1
1Dept. Pharmacol., Fukushima Med. Univ. Sch. Med., 2Dept. Pharmacokin and Pharmacodyn., Shizuoka Univ. Sch. Pharm. Sci.
Journal of Pharmacological Sciences 118 (suppl) 262-262, 2012.

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P3-20-2 Comparative study of biological activity of three commercial products of alkaline extract of leaves of Sasa senanensis Rehder

Hiroshi Sakagami1, Tomohiko Matsuta2, Kazue Satoh3, Shigemi Terakubo4, Taisei Kanamoto4, Hideki Nakashima4, Yurika Morita5, Atsuko Ohkubo5, Tadashi Tsuda5, Katsuyoshi Sunaga5, Madoka Kitajima6, Hiroshi Oizumi6, Takaaki Oizumi6
1Div. Pharmacol., Meikai Univ. Sch. Dent., 2MPL, Meikai Univ. Sch. Dent., 3Dep. Anatomy, Sch. Medicine, Show Univ., 4Dept. Microbiol., St. Marianna Univ., 5Lab. Pharmacother., Dept. Clin. Dietet Hu. Nutri., Fac. Pharm. Sci., Josai Univ., 6Daiwa Biol. Res. Inst. Co.Ltd.
Journal of Pharmacological Sciences 118 (suppl) 262-262, 2012.

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P3-20-3 A new in vitro method for investigating drug-drug interaction with Kampo medicine

Yuki Nishimura1, Norimitsu Kurata2, Takehiko Sambe1, Mariko Iwase1, Naoki Uchida1, Yoshie Harimoto1, Makiko Tajika1, Hirokazu Toshima1, Shinichi Kobayashi1
1Dept. Clin Pharmacol., Showa Univ. Sch. Med., 2Fac. Arts and Sci. at Fujiyoshida, Showa Univ.
Journal of Pharmacological Sciences 118 (suppl) 262-262, 2012.

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P3-20-4 Effects of omeprazole, lansoprazole and rabeprazole on ticlopidine metabolism in human liver microsome

Minoru Watanabe1, 2, Yuichi Kinoshita2, Yuko Takeba2, Toshio Kumai3, Sachiko Takenoshita2, Yuki Ohta2, Naoki Matsumoto2
1Inst. Animal Exp., St. Marianna Univ. Grad. Sch. Med., 2Dept. Pharmacol., St. Marianna Univ. Sch. Med., 3Dept. Pharmacogenomics, St. Marianna Univ. Grad. Sch. Med.
Journal of Pharmacological Sciences 118 (suppl) 263-263, 2012.

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P3-20-5 Brain concentration of AM404 after oral administration of acetaminophen at a dose of 20 mg/kg to rats

Shun Muramatsu1, 2, Seiji Shiraishi2, Akiko Toda3, Masayuki Mogi3, Mayumi Hara1, Yoshihiko Kawasaki1, Mikio Taniguchi1, Yasuhito Uezono2
1R&D. Showa Yakuhin Kako Co.,Ltd., 2Cancer Pathophysiol. Div., NCCRI, 3Pharmacokinet & Bioanal Center SNBL
Journal of Pharmacological Sciences 118 (suppl) 263-263, 2012.

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P3-20-6 Expression and activity of Flavin-containing monooxygenase (FMO) in rat blood-brain barrier

Eiichi Sakurai1, Yukari Ueda1, Yukari Mori1, Yasuhumi Shinmyouzu1, Eiko Sakurai2
1Dept. Pharmaceutics, Tokushima Bunri Univ., 2Faculty of Pharmacy, Iwaki Meisei Univ.
Journal of Pharmacological Sciences 118 (suppl) 263-263, 2012.

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P3-20-7 Caffeine effects on attentional networks： a pharmacological fMRI study

Yumiko Ikeda1, Michihiko Koeda2, Woochan Kim2, Noriaki Yahata3, Hidehiko Takahashi4, Amane Tateno2, Yoshiro Okubo2, Hidenori Suzuki1
1Dept. Pharmacol., Nippon Med Sch., 2Dept. Neuropsych., Nippon Med Sch., 3Dept. Neuropsych, Grad Sch of Med., Univ of Tokyo, 4Dept. Psychiatry., Grad Sch of Med., Kyoto Univ.
Journal of Pharmacological Sciences 118 (suppl) 263-263, 2012.

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P3-20-8 Comparative effect of olmesartan and candesartan on lipid metabolism in patients with hypertension： a retrospective observational study

Yayoi Nishida1, Yasuo Takahashi1, Satoshi Asai2
1Div. Genom. epidemiol. Clin. Trials, Nihon Univ. Sch. Med, 2Div. Pharmacol., Dept. Biol. Sci., Nihon Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 264-264, 2012.

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P3-20-9 The adverse effects of trichlormethiazide, focusing on serum electrolyte and uric acid levels： a retrospective database study

Yasuo Takahashi1, Yayoi Nishida1, Satoshi Asai2
1Div. Genom. epidemiol. Clin. Trials, Nihon Univ. Sch. Med, 2Div. Pharmacol., Dept. Biol. Sci., Nihon Univ. Sch. Med
Journal of Pharmacological Sciences 118 (suppl) 264-264, 2012.

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