Journal of Pharmacological Sciences 124巻 suppl号

前の号 次の号

発行元: 日本薬理学会

ISSN: 1347-8613

ISSN（オンライン）: 1347-8648

前雑誌: Japanese Journal of Pharmacology

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PL1 Aquaporin water channels: from atomic structure to malaria

Peter Agre
Johns Hopkins Malaria Research Institute (JHMRI), Bloomberg School of Public Health
Journal of Pharmacological Sciences 124 (suppl) 2-2, 2014.

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PL2 Angiogenesis: Basic and Translational Aspects

Napoleone Ferrara
Pathology, Basic Sciences, Moores Cancer Center, the University of California, San Diego
Journal of Pharmacological Sciences 124 (suppl) 2-2, 2014.

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JPSPL The Endothelial Saga: From Function to Dysfunction

Paul M.Vanhoutte
Department of Pharmacology and Pharmacy and State Key Laboratory of Pharmaceutical Biotechnology, Li Ka Shing Faculty of Medicine, University of Hong Kong
Journal of Pharmacological Sciences 124 (suppl) 4-4, 2014.

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MDP Discovery of the unknown peptides, and their innovation for novel drugs

Hisayuki Matsuo
National Cerebral and Cardiovascular Center of Japan Research Institutes
Journal of Pharmacological Sciences 124 (suppl) 6-6, 2014.

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SL1 The finding, development and progress of potassium channel openers

Teruyuki Yanagisawa
Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 8-8, 2014.

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SL2 Multiple Roles of NADPH Oxidases in the Vasculature

Kathy Griendling
Medicine, Research and Faculty Development, Faculty Development, Emory University
Journal of Pharmacological Sciences 124 (suppl) 8-8, 2014.

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SL3 RacGAP α2-chimaerin in spine development and cognition

Shigeyoshi Itohara
RIKEN Brain Sci. Inst
Journal of Pharmacological Sciences 124 (suppl) 8-8, 2014.

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SL4 Medical response to the Great East Japan Earthquake in the Ishinomaki Medical Zone and our efforts to prepare for future disasters

Tadashi Ishii
Dept. Education and support for community medicine, Tohoku Univ. Hosp
Journal of Pharmacological Sciences 124 (suppl) 8-8, 2014.

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SL6 Cognitive training to achieve smart ageing

Ryuta Kawashima
IDAC, Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 9-9, 2014.

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SL6 Structural studies on drug-target membrane proteins

So Iwata
Depart. Cell Biol. Kyoto Univ. Grad. Sch. Med, Riken SPring8 Center
Journal of Pharmacological Sciences 124 (suppl) 9-9, 2014.

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SL7 Drug targets network for Anti-Parkinson's Disease and mechanisms of Baicalein

Guan-Hua Du
Chinese Pharmacological Society, Institutes of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College
Journal of Pharmacological Sciences 124 (suppl) 9-9, 2014.

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SL8 Fundamental principles and current topics of the regulations on biomedical research

Shigeto Yonemura
Grad. Sch. Law&Politics, Univ. of Tokyo
Journal of Pharmacological Sciences 124 (suppl) 9-9, 2014.

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JPSSL Towards a third generation antihistamines: myth or reality?

Rob Leurs
VU University Amsterdam, Departement of Medicinal Chemistry
Journal of Pharmacological Sciences 124 (suppl) 12-12, 2014.

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EAL Molecular identification of transporters and their application to molecular target drug discovery

Yoshikatsu Kanai
Bio-Sys. Pharmacol., Dept. Pharmacol., Osaka Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 14-14, 2014.

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AL1 Pharmacological studies on the roles of 5-HT1A receptors in the central nervous system function

Yukio Ago
Lab. Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci. Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 16-16, 2014.

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AL2 Visualization of metabotropic glutamate receptor signaling

Yohei Okubo
Dept. Pharmacol., Grad. Sch, of Med., Univ. of Tokyo
Journal of Pharmacological Sciences 124 (suppl) 16-16, 2014.

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AL3 Analysis of signaling cascade of transcription factors in joint tissue toward drug discovery

Takeshi Takarada
Lab. Mol. Pharmacol, Kanazawa Univ. Grad. Sch. Natural Sci. Tech
Journal of Pharmacological Sciences 124 (suppl) 16-16, 2014.

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NRL1 Molecular pathological role of GRK2 in vascular endothelial cell dysfunction

Yuichi Hattori
Dept. Mol. Med. Pharmacol., Graduate sch. of Med. and Pharm., Univ. of Toyama
Journal of Pharmacological Sciences 124 (suppl) 18-18, 2014.

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NRL2 Establishment of irritable bowel syndrome animal model by intermittent sleep deprivation

Fukie Yaoita
Dept. Pharmacol., Tohoku Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 18-18, 2014.

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NRL3 The novel neuronal functions controlling fear and anxiety

Takayuki Yoshida
Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 18-18, 2014.

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JS2-1-1 Current status and future prospect of pharmaceutical development using iPS cells

Tatsutoshi Nakahata
Dept. Clinical Application, Center for iPS Cell Research and Application(CiRA), Kyoto University
Journal of Pharmacological Sciences 124 (suppl) 20-20, 2014.

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JS2-1-2 Differentiation of human iPS cells into hepatocytes and enterocytes, and application to pharmacokinetic studies

Tamihide Matsunaga
Dept.Clin. Pharmacy, Grad. Sch. Pharm. Sci., Nagoya City Univ
Journal of Pharmacological Sciences 124 (suppl) 20-20, 2014.

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JS2-1-3 New testing methods for safety pharmacology using human-iPS derived tissue cells

Yuko Sekino
Div. Pharmacol. Inst Health Sci
Journal of Pharmacological Sciences 124 (suppl) 20-20, 2014.

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JS2-1-4 Initiatives of the application of human iPS cell-derived cells for drug safety evaluation by pharmaceutical companies

Norimasa Miyamoto
JPMA TF-5 (Eisai Co., Ltd.)
Journal of Pharmacological Sciences 124 (suppl) 20-20, 2014.

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SS1-1-1 Endothelial function as a surrogate biomarker

Shinichiro Ueda
Dept. Clin. Pharmacol. & Ther, Univ. of the Ryukyus
Journal of Pharmacological Sciences 124 (suppl) 22-22, 2014.

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SS1-1-2 Endothelin receptor signalosome as a target for a novel therapeutic strategy against cardiovascular diseases

Takahiro Horinouchi, Koji Terada, Tsunehito Higashi, Akimasa Hoshi, Soichi Miwa
Dept. Cell. Pharmacol., Hokkaido Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 22-22, 2014.

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SS1-1-3 Future direction of cardiovascular disease treatment from the view of the endothelial cell dysfunction

Koichi Node
Department of Cardiovascular Medicine, Saga University
Journal of Pharmacological Sciences 124 (suppl) 22-22, 2014.

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S1B-1-1 Domestic and international situation regarding EU Cosmetic directive

Hajime Kojima
Japanese Center for the Validation of Altermative Methods, National Institute of Health Sciences
Journal of Pharmacological Sciences 124 (suppl) 24-24, 2014.

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S1B-1-2 Trend on alternatives to animal testing in the cosmetic industry

Shigenobu Hagino
Shiseido Research Center
Journal of Pharmacological Sciences 124 (suppl) 24-24, 2014.

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S1B-1-3 Development of alternatives to animal experimentation: A recent trend for investigating food or chemical safety

Masaharu Akita1, Yuji Yoshiyama2
1Dept. Nutri. Diet., Kamakura Women's Univ, 2Divi. Commu. Pharma, kitasato Univ. Sch. Pharma
Journal of Pharmacological Sciences 124 (suppl) 24-24, 2014.

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S1B-1-4 The new Japanese Act on Welfare and Management of Animals and its future perspective

Yoshie Kakuma
Dept. Anim. Sci., Teikyo Univ. Sci
Journal of Pharmacological Sciences 124 (suppl) 24-24, 2014.

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S1C-2-1 MRI imaging of non-human primate neurodegenerative disease model

Hirotaka James Okano
Div. Regen Med., Jikei Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 25-25, 2014.

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S1C-2-2 Study of neuronal network regulating sleep/wakefulness using activity manipulation of neurons

Akihiro Yamanaka, Tomomi Tsunematu, Ayumu Inutsuka, Sawako Tabuchi
Dept. Neurosci. II, Res. Inst. Env. Med., Univ. Nagoya
Journal of Pharmacological Sciences 124 (suppl) 25-25, 2014.

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S1C-2-3 Analysis of pain mechanisms by applying the methods of optgenetics and chemical genetics

Minoru Narita
Dept. of Pharmacol., Hoshi Univ. Sch. of Pharm. and Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 25-25, 2014.

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S1C-2-4 Visualizing hippocampal neuronal circuit activity during behavior by two-photon calcium imaging

Masaaki Sato
RIKEN BSI, JST PRESTO
Journal of Pharmacological Sciences 124 (suppl) 25-25, 2014.

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S1D-3-1 Dissecting the role of autophagy in neuropathic pain discloses new trends in the pharmacologic control

Giacinto Bagetta
Dept. Pharm., Health Sci. Nutr., Univ. Calabria
Journal of Pharmacological Sciences 124 (suppl) 26-26, 2014.

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S1D-3-2 Peripheral nicotinic acetylcholine receptor is a novel target for neuropathic pain

Shiroh Kishioka, Norikazu Kiguchi, Fumihiro Saika, Yuka Kobayashi
Dept. Pharmacol., Wakayama Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 26-26, 2014.

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S1D-3-3 Microglia in neuropathic pain

Kazuhide Inoue
Dept. Mol & System Pharmacol., Fuculty Pharmaceu.Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 26-26, 2014.

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S1E-4-1 Selective regulation of tumor angiogenesis targeting transglutaminase 2

Soichi Kojima, Eun-Seo Lee
Micro-signal Unit, CLST, RIKEN
Journal of Pharmacological Sciences 124 (suppl) 27-27, 2014.

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S1E-4-2 Inhibitory mechanism of PACAP specific receptor PAC1 gene by transglutaminase 2

Atsuro Miyata2, Ayako Miura1, Yuki Kambe1, Takashi Kurihara1, Kazuhiko Inoue1, Hideki Tatsukawa2, Soichi Kojima2
1Dept. Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ, 2Micro-signal Unit, CLST, RIKEN
Journal of Pharmacological Sciences 124 (suppl) 27-27, 2014.

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S1E-4-3 Gαh/TG2 enhances adenylylcyclase 8 activity in human and rat glioma cells

Yutaro Obara1,2, Yoshimi Yanagihata2, Tomohiro Abe2, Laila Dafik3, Kuniaki Ishii1, Norimichi Nakahata2
1Div. Pharmacol., Yamagata Univ. Sch. Med, 2Dept. Cell Signal., Grad. Sch. Pharmaceut. Sci., Tohoku Univ, 3Dept. Chem and Chem. Eng., Stanford Univ
Journal of Pharmacological Sciences 124 (suppl) 27-27, 2014.

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S1E-4-4 Transglutaminase 2-mediated regulation of cell proliferation in hepatocellular carcinoma cells

Yohei Saito1, Yumi Yamamoto1, Fumihiko Yamamoto1, Yoshikazu Kuwahara2, Manabu Fukumoto2, Yasuhito Ohkubo1
1Dept. of Radiopharm., Tohoku Pharm. Univ, 2Dept. Path., IDAC, Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 27-27, 2014.

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S1B-5-1 NEURONAL HISTAMINE MEDIATES THE ANOREXIANT EFFECT OF OLEOYLETHANOLAMIDE

M.Beatrice Passani
NEUROFARBA, University of Florence
Journal of Pharmacological Sciences 124 (suppl) 28-28, 2014.

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S1B-5-2 A protein kinase C- y knockout Parkinsonian model: Involvement of Pak-Interacting Exchange Factor-β

Naoaki Saito
Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University
Journal of Pharmacological Sciences 124 (suppl) 28-28, 2014.

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S1B-5-3 Searching a drug target for allergic diseases targeting intracellular signaling molecule

Hiroyuki Fukui
Dept. Mol. Pharmacol., Inst. Health Biosci., Univ. Tokushima Grad. School, Dept. Mol. Stud. Incurable Dis., Inst. Health Biosci., Univ. Tokushima Grad. School
Journal of Pharmacological Sciences 124 (suppl) 28-28, 2014.

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S1B-5-4 NEURONAL HISTAMINE IS ESSENTIAL FOR SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI) EFFECTS

Patrizio Blandina
Dept of NEUROFARBA, University of Florence
Journal of Pharmacological Sciences 124 (suppl) 28-28, 2014.

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S1D-6-1 Physiological and pharmacological actions involved in pharyngeal and laryngeal sensation

Junichi Kitagawa
Div. Oral Physiology, Niigata Univ, Grad. Sch. Med. Dent. Sci
Journal of Pharmacological Sciences 124 (suppl) 29-29, 2014.

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S1D-6-2 A role for vagus afferent signal: from gastrointestinal sensor to brain function

Akihiko Kitamura, Hisayuki Uneyama
Inst Innovation, Ajinomoto Co., Inc
Journal of Pharmacological Sciences 124 (suppl) 29-29, 2014.

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S1D-6-3 Targeting Thermosensing TRP channel for Preventing Aspiration Pneumonia: Anti-Aspiration Drugs

Satoru Ebihara1, Yasunori Sumi3, Takae Ebihara2
1Dept. Int. Med. Rehabil. Sci., Tohoku Univ. Grad. Sch. Med, 2Dept. Geriatr. Gerontol., IDAC, Tohoku University, 3Div. Oral Dental., Dept. Adv. Med., NCGG
Journal of Pharmacological Sciences 124 (suppl) 29-29, 2014.

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S1D-6-4 Application of oral sense to remedy for dry mouth

Shizuko Satoh-Kuriwada
Dept. Oral Diagnosis, Tohoku Univ. Sch. Dent
Journal of Pharmacological Sciences 124 (suppl) 29-29, 2014.

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S1E-7-1 Regulation of neutrophils by plasma protein HRG and development of drug for the treatment of sepsis

Masahiro Nishibori1, Hidenori Wake1, Shuji Mori2
1Dept. Dent. Pharmacol., Okayama Univ, 2Shujitsu Univ, Faculty of Pharmaceutical Sci
Journal of Pharmacological Sciences 124 (suppl) 30-30, 2014.

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S1E-7-2 Development of novel non-invasive anti-cancer drug delivery system using tumor-homing peptides

Eisaku Kondo
Div. Oncological Pathol., Aichi Cancer Center Res. Inst, Dept. Epidemiol., Nagoya Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 30-30, 2014.

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S1E-7-3 Development of PET diagnosis and therapeutic drugs for malignant tumors targeting amino acid transporters

Yoshikatsu Kanai
Div. Bio-system Pharmacol., Dept. Pharmacol., Grad. Sch. Med., Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 30-30, 2014.

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S1E-7-4 Challenges to innovative drug discovery by academia in Japan: Strategies to solve difficulties

Tamiko Suzuki-Nishimura
Pharmacy School, Shujitsu. Univ
Journal of Pharmacological Sciences 124 (suppl) 30-30, 2014.

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S1B-8-1 Cardiovascular effects of a phytochemical, sinomenine, contained in Sinomenium acutum Rehder et Wilson

Hiroyasu Satoh1, Seiichiro Nishida2
1Health Life Sci. Shitennoji Univ, 2Nara Dongo Hosp
Journal of Pharmacological Sciences 124 (suppl) 31-31, 2014.

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S1B-8-2 Sesquiterpenoids: phytochemicals for fight against cancer

Tomoka Takatani-Nakase, Koichi Takahashi
Dept. Pharmaceut., Sch. Pharm. and Pharmaceut. Sci., Mukogawa Women's Univ
Journal of Pharmacological Sciences 124 (suppl) 31-31, 2014.

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S1B-8-3 Effects of evodiamine, a major alkaloid of Goshuyu, on TRPV1

Yoshinori Kobayashi
sch. pharmacy, Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 31-31, 2014.

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S1B-8-4 Vascular pharmacology of a functional flavonoid "quercetin" contained in Kampo medicine

Seiichiro Nishida1, Hiroyasu Satoh2
1Dongo Hosp, 2Health Life Sci. Shitennoji Univ
Journal of Pharmacological Sciences 124 (suppl) 31-31, 2014.

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S1C-9-1 Bacterial infection and acute lung injury

Teiji Sawa
Dept.Anesth., Kyoto Pref. Univ. Med
Journal of Pharmacological Sciences 124 (suppl) 32-32, 2014.

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S1C-9-2 Pathogenicity of influenza virus and development of the ARDS

Yumiko Imai
Dept. Biological Informatics and Experimental Therapeutics, Akita Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 32-32, 2014.

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S1C-9-3 GRK2 as a potential therapeutic target for sepsis-induced acute lung injury (ALI)

Wakana Ohashi, Yuichi Hattori
Dept. of Mol. Med. Pharmacol., Graduate sch. of Med. and Pharm., Univ. of Toyama
Journal of Pharmacological Sciences 124 (suppl) 32-32, 2014.

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S1C-9-4 Posttranscriptional regulation of inflammation by an RNase, Regnase-1

Osamu Takeuchi
Dept. Infect. Prevent., Inst. Virus Res., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 32-32, 2014.

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S1D-10-1 Role of the astrocyte in functional compensation at the intact hemisphere contralateral to a stroke

Takatsuru Yusuke1, Junichi Nabekura2, Noriyuki Koibuchi1
1Det. Integrative Physiol., Gunma Univ. Grad. Sch. Med, 2Div. Homeostatic Develop., NIPS
Journal of Pharmacological Sciences 124 (suppl) 33-33, 2014.

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S1D-10-2 Activated astrocytes regulate migration of new neurons toward the injury

Naoko Kaneko, Kazunobu Sawamoto
Dept. Developmental & Regenerative Biol., Nagoya City Univ. Sch. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 33-33, 2014.

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S1D-10-3 Translational research of neuropsychiatric disorders focusing on microglia

Takahiro Kato1,2, Shigenobu Kanba1
1Dept. Neuropsychiatry., Sch. Med., Kyushu Univ, 2Innov. Cent. Med. Redox Navi., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 33-33, 2014.

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S1D-10-4 Glia-mediated ischemic tolerance

Schuichi Koizumi1,2, Hirayama Yuri1
1Dept. Neuropharmacol., Facul. Med., Univ. Yamanashi, 2CREST, Japan Science and Technology Agency
Journal of Pharmacological Sciences 124 (suppl) 33-33, 2014.

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S1E-11-1 A critical role of ubiquitination in endothelin receptor trafficking

Soichi Miwa, Koji Terada, Tsunehito Higashi, Nepal Prabha, Takahiro Horinouchi
Dept. Cell. Pharmacol., Hokkaido Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 34-34, 2014.

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S1E-11-2 Regulation of GPCR signaling by RGS proteins

Tohru Kozasa
Laboratory of Systems Biology and Medicine, RCAST, Univ. of Tokyo
Journal of Pharmacological Sciences 124 (suppl) 34-34, 2014.

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S1E-11-3 Regulation of G protein-coupled receptor kinase and desensitization-targeted potential therapeutic approach

Taroh Iiri, Noriko Makita
Dept. Endocrinol. and Nephrol., Univ. of Tokyo
Journal of Pharmacological Sciences 124 (suppl) 34-34, 2014.

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S1E-11-4 G protein-coupled receptor kinase 6 is involved in engulfment of apoptotic cells

Michio Nakaya, Hitoshi Kurose
Dept. of Pharmacol. Toxicol., Grad. Sch. Pharm. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 34-34, 2014.

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S1B-12-1 Brain D-serine signaling and schizophrenia

Toru Nishikawa
Dept. Psychiatry & Behav. Sci., TMDU
Journal of Pharmacological Sciences 124 (suppl) 35-35, 2014.

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S1B-12-2 Roles of serine racemase and D-serine in vivo

Hisashi Mori
Dept. Mol. Neurosci., Grad. Sch. Med. & Pharmaceut. Sci., Univ. Toyama
Journal of Pharmacological Sciences 124 (suppl) 35-35, 2014.

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S1B-12-3 Chiral amino acid metabolomics in mammals -distribution and regulation of D-amino acids-

Kenji Hamase1, Yurika Miyoshi1, Masashi Mita2, Ryuichi Konno3
1Grad. Sch. Pharmaceut. Sci., Kyushu Univ, 2Shiseido Co., Ltd, 3Dept. Pharmaceut. Sci., International Univ. Health Welfare
Journal of Pharmacological Sciences 124 (suppl) 35-35, 2014.

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S1B-12-4 D-amino acids and salivary glands

Masanobu Yoshikawa1, Migiwa Okubo2, Yirika Miyoshi3, Kenji Hamase3, Chieko Murayama1, Ryuichi Konno4, Hiroyuki Kobayashi1, Mitsuru Kawaguchi2
1Dept. Clinical Pharmacol., Tokai Univ. Sch. Med, 2Dept. Pharmacol., Tokyo Dental College, 3Dept. Bioanalytical Chem., Graduate Sch. Pharmaceu. Sci., Kyushu Univ, 4Dept. Pharmaceut. Sci., Int. Univ. Health Welfare
Journal of Pharmacological Sciences 124 (suppl) 35-35, 2014.

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S1C-13-1 Several attempts to promote basic medical research in Physiological Society of Japan, and Gunma University

Noriyuki Koibuchi
Dept. Integrative Physiol., Gunma Univ. Grad. Sch. Med, Education Committee, Physiol. Soc. Japan
Journal of Pharmacological Sciences 124 (suppl) 36-36, 2014.

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S1C-13-2 Clinical Pharmacology Too young to die?

Shinichiro Ueda
Dept. Clin. Pharmacol. & Ther, Univ. of the Ryukyus
Journal of Pharmacological Sciences 124 (suppl) 36-36, 2014.

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S1C-13-3 To activate pharmacological sciences by proposals from academic societies

Teruyuki Yanagisawa
Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 36-36, 2014.

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S1C-13-4 Promotion and revitalization of pharmacological education and the Pharmacological Society: Proposal from the committee of planning and education

Nobuyuki Yanagihara
Dept. Pharmacol., Univ. Occup. & Env. Health, Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 36-36, 2014.

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S1D-14-1 Pathophysiological role of TRP channel in immune cell during the progression of cerebral ischemic injury

Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kaneko
Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 37-37, 2014.

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S1D-14-2 The Role of Prostaglandin E2 in ischemic brain injury

Yuri Ikeda-Matsuo
Lab. Pharmacol., Sch. Pharmac. Sci., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 37-37, 2014.

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S1D-14-3 Roles of astrocytes on vascular permeability in damaged brain: as a possible target of anti-edema drugs

Yutaka Koyama, Shotaro Michinaga
Lab. of Pharmacol., Faculty of Pharmacy, Osaka Ohtani Univ
Journal of Pharmacological Sciences 124 (suppl) 37-37, 2014.

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S1D-14-4 Pharmacological interventions against intracerebral hemorrhage: lessons from animal studies

Hiroshi Katsuki, Hideaki Matsushita, Masanori Hijioka
Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ
Journal of Pharmacological Sciences 124 (suppl) 37-37, 2014.

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S2B-15-1 Differences of the educational system of Pharmaceutical systems among Japan and other countries

Atsumi Nitta
Dept. Pharmaceutical Ther. and Neuropharmacol.Fac. of Pharmaceutical Sci., Grad. Sch. of Med. and Pharmaceutical Sci., Univ of Toyama
Journal of Pharmacological Sciences 124 (suppl) 38-38, 2014.

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S2B-15-2 Difference of Pharmaceutical Education between Japan and the USA -Importance of raising awareness of habitually reading clinical studies-

Naoto Nakagawa
Department of Pharmaceutical Sciences, Tohoku University Hospital
Journal of Pharmacological Sciences 124 (suppl) 38-38, 2014.

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S2B-15-3 PharmD is here to stay

Jack T.Seki
Oncology, Princess Margaret Hospital, Leslie Dan, Faculty of Pharmacy, University of Toronto
Journal of Pharmacological Sciences 124 (suppl) 38-38, 2014.

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S2B-15-4 Rising public expectations of pharmacists for better pharmacotherapy

Kenichi Tamiya
Ministry of Health, Labour and Welfare
Journal of Pharmacological Sciences 124 (suppl) 38-38, 2014.

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S2C-16-1 Regulation of leukocyte distribution by the autonomic nerves

Tooru Abo
Sch.Med.Niigata Univ
Journal of Pharmacological Sciences 124 (suppl) 39-39, 2014.

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S2C-16-2 Adrenoceptor-mediated regulation of dendritic cell functions

Yoshiki Yanagawa, Hiroko Togashi
Dept. Pharmacol, Sch. Pharmaceu. Sci., Health Sci. Univ. of Hokkaido
Journal of Pharmacological Sciences 124 (suppl) 39-39, 2014.

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S2C-16-3 Pharmacological effects of ginseng saponins on functions of nervous, endocrine and immune systems in vitro

Eiichi Tachikawa1, Saori Nakagawa2, Susumu Yamato2, Masao Takei3
1Dept. Endocrine & Neural Pharmacol., Sch. Pharm., Tokyo Univ. of Pharm.& Life Sci, 2Dep. Bio-Anal. Chem., Niigata Univ. Pharm. & Applied Life Sci, 3Jinkei Hospital
Journal of Pharmacological Sciences 124 (suppl) 39-39, 2014.

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S2C-16-4 Modulation by the immune system and plant flavonoids in the functions of the sympatho-adrenal medullary system

Nobuyuki Yanagihara1, Yumiko Toyohira1, Keita Takahashi1, Hirohide Inagaki1, Xiaojia Li1, Susumu Ueno2, Masato Tsutsui3, Kojiro Takahashi1
1Dept. Pharmacol., Univ. Occup. & Env. Health. Sch. Med, 2Dept. Occup. Toxicol. Inst. Industr. Ecolog. Sci., Univ. Occup. & Env. Health, 3Dept. Pharmacol., Grad. Sch. Med., Univ. The Ryukyus
Journal of Pharmacological Sciences 124 (suppl) 39-39, 2014.

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S2D-17-1 The role of ER stress in ischemic preconditioning

Zheng-Hong Qin
Department of Pharmacology, Soochow University School of Pharmaceutical Science
Journal of Pharmacological Sciences 124 (suppl) 40-40, 2014.

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S2D-17-2 ER stress and Parkinson's disease: relevance to neurodegeneration

Takafumi Hasegawa
Dept. Neurology. Tohoku University. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 40-40, 2014.

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S2D-17-3 Involvement of endoplasmic reticulum stress in ALS and its therapeutic strategies

Masamitsu Shimazawa, Hideaki Hara
Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ
Journal of Pharmacological Sciences 124 (suppl) 40-40, 2014.

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S2D-17-4 The molecular mechanism of neurodegeneration caused by ALS-related sigma-1 receptor mutation

Hideaki Tagashira, Yasushi Yabuki, Norifumi Shioda, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 40-40, 2014.

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S2E-18-1 Regulation of peripheral circulation by TRPC channels and its therapeutic application

Takuro Tomita1,2, Masaaki Sumita1, Tsukasa Shimauchi1, Satomi Kita4, Takahiro Iwamoto4, Motohiro Nishida3
1Grad. Sch. Pharmacol., Kyushu Univ, 2Inst. Adv.Studies, Kyushu Univ, 3Div. Cardiocirculatory Signaling, Okazaki Inst. Integ. Biosci., NIPS, NINS, 4Dept. Pharmacol., Fac. Med., Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 41-41, 2014.

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S2E-18-2 Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

Mayumi Kajimura1,2, Takayuki Morikawa1,2, Takako Hishiki1,2, Tomomi Nakamura1, Makoto Suematsu1,2
1Dept. Biochem., Sch. Med., Keio Univ, 2JST ERATO Suematsu Gas Biology Project
Journal of Pharmacological Sciences 124 (suppl) 41-41, 2014.

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S2E-18-3 Mechanisms of liver repair and sinusoidal reconstruction after acute liver injury and implications for therapy

Yoshiya Ito
Dept. Mol. Pharmacol., Grad. Sch. of Med. Sci. Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 41-41, 2014.

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S2B-19-1 Roles of Modeling and Simulation in Regulatory Science

Akihiro Hisaka
Pharmacology and Pharmacokinetics, The University of Tokyo Hospital
Journal of Pharmacological Sciences 124 (suppl) 42-42, 2014.

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S2B-19-2 What is causing the growing the placebo response in studies of neuropsychiatric disorders?

Tetsuo Nakabayashi
Pharmaceuticals and Medical Devices Agency
Journal of Pharmacological Sciences 124 (suppl) 42-42, 2014.

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S2B-19-3 Corporate Efforts related to Regulatory Science

Hiroyuki Sato
Japan Pharmaceutical Manufacturers Association, Regulatory Affairs Committee, SHIONOGI & CO., LTD
Journal of Pharmacological Sciences 124 (suppl) 42-42, 2014.

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S2B-19-4 Regulatory science and basic pharmacology

Norio Matsuki
Lab. Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ. Tokyo, Lab Pharmaceut Reg Sci, Grad Sch Pharmaceut Sci. Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 42-42, 2014.

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S2D-20-1 Involvement of microglial activation induced by ab in hippocampal neurogenesis in adult mice

Toshiaki Kume1, Yasuhiko Izumi1, Akinori Akaike1,2
1Dept. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ, 2Grad. Sch. Pharm. Sci., Nagoya Univ
Journal of Pharmacological Sciences 124 (suppl) 43-43, 2014.

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S2D-20-2 The new functions of microglia on the pathological side and on the physiological side-the possibility to treat neuronal disease based on microglial polarity

Kaoru Sato
Div. Pharmacology, NIHS
Journal of Pharmacological Sciences 124 (suppl) 43-43, 2014.

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S2D-20-3 Calcium-dependent N-cadherin upregulation mediates reactive astrogliosis and neuroprotection after brain injury

Kazunori Kanemaru1, Jun Kubota1, Hiroshi Sekiya1, Kenzo Hirose2, Yohei Okubo1, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo, 2Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 43-43, 2014.

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S2D-20-4 Analysis of glia-neuron interaction by using opto-fMRI

Kenji Tanaka1, Keitaro Yoshida1, Ming Xu1, Keigo Hikishima2, Hideyuki Okano2, Masaru Mimura1, Norio Takata1
1Dept. Neuropsychiatry, Keio Univ. Sch. Med, 2Dept. Physiol., Keio Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 43-43, 2014.

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S2C-21-1 Optogenetical manipulation of hypothalamic neurons involved in sleep/ wakefulness regulation

Tomomi Tsunematsu, Akihiro Yamanaka
Dept. NeurosciII., RIEM, Nagoya Univ
Journal of Pharmacological Sciences 124 (suppl) 44-44, 2014.

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S2C-21-2 Optogenetic control of central serotonergic systems and the mechanisms of action of serotonin reuptake inhibitors

Yu Ohmura
Dept. Neuropharmacol., Hokkaido Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 44-44, 2014.

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S2C-21-3 Optogenetic activation of the mPFC and escalated aggression

Aki Takahashi1,2, Kazuki Nagayasu3, Shuzi Kaneko4, Tsuyoshi Koide1,2
1Mouse Genomics Resource Lab., Natl. Inst. Genet, 2SOKENDAI, 3Lab. of Mol. Neuropharm., Grad. Sch. of Pharmaceut. Sci., Osaka Univ, 4Dept. of Mol. Pharmacol., Grad. Sch. of Pharmaceut. Sci., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 44-44, 2014.

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S2C-21-4 Optogenetic activation of dorsal raphe serotonin neurons enhances patience for future rewards

Katsuhiko Miyazaki1, Kayoko Miyazaki1, Kenji Tanaka2, Akihiro Yamanaka3, Aki Takahashi4, Kenji Doya1
1OIST, 2Dept. of Neuropsychi., Keio Univ. Sch. Med, 3Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, 4Mouse Genomics Resource Laboratory, National Institute of Genetics
Journal of Pharmacological Sciences 124 (suppl) 44-44, 2014.

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S2D-22-1 Inhibitor of differentiation/DNA binding protein 2 regulates the expression of the cardiac T-type calcium channels

Andres Daniel Maturana
Nagoya University Graduate School o f Bioagricultural Sciences
Journal of Pharmacological Sciences 124 (suppl) 45-45, 2014.

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S2D-22-2 Regulation of L-type Ca2+ channels via cross-talk of Ca2+ signaling in cardiac myocytes

Satomi Adachi-Akahane1, Hiroko Izumi-Nakaseko2
1Dept. Physiol., Scho. Med., Fac. Med., Toho Univ, 2Dept. Pharmacol., Scho. Med., Fac. Med., Toho Univ
Journal of Pharmacological Sciences 124 (suppl) 45-45, 2014.

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S2D-22-3 Molecular mechanism of junctional membrane-targeting of cardiac and skeletal L-type calcium channels

Tsutomu Nakada1, Bernhard Flucher2, Toshihide Kashihara1, Masatoshi Komatsu1, Mitsuhiko Yamada1
1Dept. of Mol. Pharmacol., Shinshu Univ. Sch. of Med, 2Dept. of Physiol. & Med. Phys., Innsbruck Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 45-45, 2014.

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S2D-22-4 Regulation of L-type (Cav1.2) Ca2+ channels by calmodulin and ATP

Masaki Kameyama1, Etsuko Minobe1, Jianjun Xu1, Dongyun Han1, Hadhimulya Asmara1, Asako Kameyama1, Rui Feng1,2, Shuyan Liu1,2, Liying Hao2
1Dept. Physiol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ, 2Dept. Pharmaceu. Toxicol., Sch. Pharmac. China Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 45-45, 2014.

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S2E-23-1 Roles of ATP-sensitive K+ channels in the prevention of ischemia-induced cardiac tachyarrhythmia

Naoko Matsushita1, Masamichi Hirose2, Eiichi Taira1
1Dept. of Pharmacol. Iwate Medical Univ, Sch. Med, 2Dept. of Pharmacol. Iwate Medical Univ, Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 46-46, 2014.

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S2E-23-2 K ATP channels in primary afferent neurons as a potential therapeutic target for neuropathic pain

Takashi Kawano
Department of Anesthesiology and Intensive care Medicine, Kochi medical School
Journal of Pharmacological Sciences 124 (suppl) 46-46, 2014.

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S2E-23-3 Protein folding disease and ATP-sensitive potassium channels

Atsushi Sanbe, Toshinori Aoyagi, Yu Tezuka
Dept. Pharmacotherap., Iwate Medi. Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 46-46, 2014.

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S2E-23-4 Nicorandil ameliorates hypertension-related bladder dysfunction in the rat

Motoaki Saito
Dept. Pharmacol., Kochi Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 46-46, 2014.

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S2C-24-1 Abnormal cortical architectures and neuropsychiatric disorders

Ken-ichiro Kubo1, Kimiko Deguchi1, Taku Nagai2, Wei Shan2, Ayako Kitazawa1, Michihiko Aramaki1, Kazuhiro Ishii1, Kiyofumi Yamada2, Ken Inoue3, Kazunori Nakajima1
1Dept. Anatomy, Keio Univ. Sch. Med, 2Dept. Neuropsychopharmacol. & Hospital Pharmacy, Nagoya Univ. Sch. Med, 3NIN, NCNP
Journal of Pharmacological Sciences 124 (suppl) 47-47, 2014.

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S2C-24-2 Drug use during pregnancy and neuropathology of developmental disorders

Kazuhiro Takuma1, Takuya Kawanai1, Yukio Ago1, Toshio Matsuda1,2
1Lab. Medicinal Pharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ, 2Center for Child Mental Dev., United Grad. Sch. Child Dev., Osaka Univ. Kanazawa Univ, 2Hamamatsu Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 47-47, 2014.

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S2C-24-3 Immune system and perinatal programing of brain development

Taku Nagai
Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 47-47, 2014.

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S2D-25-1 T-type calcium channels as targets for pain therapeutics

Gerald.W.Zamponi
Univ. Calgary, Department of Physiology and Pharmacology
Journal of Pharmacological Sciences 124 (suppl) 48-48, 2014.

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S2D-25-2 Inhibition of synaptic transmission and G protein modulation by synthetic Cav2.2 channel peptides

Sumiko Mochida
Dept Physiol., Tokyo Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 48-48, 2014.

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S2D-25-3 The memory improvement by T-type Ca2+ channel stimulation

Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Scis
Journal of Pharmacological Sciences 124 (suppl) 48-48, 2014.

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S2D-25-4 Roles of Cav3.2 T-type Ca2+ channels in prostate cancer cells: impact on an androgen-independent stage

Atsufumi Kawabata
Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 48-48, 2014.

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S2E-26-1 Development of fluorescent probes for labile Fe(II) ion in oxidative stress

Tasuku Hirayama1, Masato Niwa1, Satoki Kadota1, Tomoyo Imamura2, Kensuke Okuda1, Hideaki Hara2, Hideko Nagasawa1
1Lab. Pham. Mad. Chem., Gifu Pharm. Univ, 2Lab. Mol. Pharmacol
Journal of Pharmacological Sciences 124 (suppl) 49-49, 2014.

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S2E-26-2 Iron metabolic disorders in hypertension

Soichiro Tajima, Nobuaki Egashira, Satohiro Masuda
Dept. Pharmacy, Kyushu Univ. Hosp
Journal of Pharmacological Sciences 124 (suppl) 49-49, 2014.

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S2E-26-3 The ameliorating effects of iron reduction on obesity, diabetes and diabetic complications

Yasumasa Ikeda
Dept. of Pharmacol., The Univ. Tokushima Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 49-49, 2014.

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S2E-26-4 Disorder of iron metabolism in chronic kidney disease

Masayoshi Nanami, Yasuyuki Nagasawa, Yukiko Hasuike, Takahiro Kuragano, Takeshi Nakanishi
Division of Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine
Journal of Pharmacological Sciences 124 (suppl) 49-49, 2014.

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S3B-27-1 Fatty acid receptors as a therapeutic target for metabolic syndrome

Akira Hirasawa1,2, Masato Takeuchi1, Ryouhei Shirai1, Zao Chen1, Shota Ishii1, Keiko Iida1
1Dept. Genomic Drug Discovery Sci., Grad. Sch. Pharmaceu. Sci. Kyoto Univ, 2Inst. Integrated Med. Sci. Tokyo Women's Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 50-50, 2014.

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S3B-27-2 'PUFA-GPR40-CREB signaling' hypothesis for the adult primate neurogenesis

Tetsumori Yamashima
Dept. Restorative Neurosurgery, Kanazawa Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 50-50, 2014.

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S3B-27-3 The possibility of a novel pain control system through intracerebral long chain fatty acid receptor GPR40

Kazuo Nakamoto, Shogo Tokuyama
Dept. Clinic. Pharm., Fac. Pharmaceu. Sci., Kobe Gakuin Univ
Journal of Pharmacological Sciences 124 (suppl) 50-50, 2014.

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S3B-27-4 Involvement of free fatty acid receptor GPR40 in the regulation of spinal nociceptive transmission

Takashi Kurihara1, Prasanna Karki1,2, Tomoya Nakamachi3, Toshihide Asada1, Megumu Yoshimura4, Seiji Shioda3, Kazunori Arita2, Atsuro Miyata1
1Dept. Pharmacol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ, 2Dept. Neurosurgery, Grad. Sch. Med. and Dent. Sci., Kagoshima Univ, 3Dept. Anat., Showa Univ., Sch. Med, 4Grad. Sch. Health Sci., Kumamoto Health Sci. Univ
Journal of Pharmacological Sciences 124 (suppl) 50-50, 2014.

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S3C-28-1 Improvement of memory function by traditional medicine in Alzheimer's disease model mice

Chihiro Tohda
Dept. Neuromedical Science, Inst. Natural Medicine, Univ Toyama
Journal of Pharmacological Sciences 124 (suppl) 51-51, 2014.

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S3C-28-2 Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in vitro and in vivo

Ichiro Kawahata1, Masaaki Yoshida2, Wen Sun1, Wataru Sawada1, Lai Yanxin1, Tohru Yamakuni1
1Dept. Pharmacol., Tohoku Uni, 2Kotaro pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 51-51, 2014.

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S3C-28-3 Clinical effects of the NChinpi on the cognitive impairment of patients with Alzheimer's disease

Takashi Seki1, Kenichi Meguro1, Tohru Yamakuni2
1Dept. Geriatric Behavioral Neurol., Tohoku Univ. Sch. Med, 2Dept. Pharmacotherapy., Tohoku Univ. Sch. Pharmaceutical
Journal of Pharmacological Sciences 124 (suppl) 51-51, 2014.

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S3C-28-4 Chotosan and cognitive deficits attributable to aging and diabetes

Kinzo Matsumoto1, Yimin Niu1, Qi Zhao1, Hironori Fujiwara1, Sachie Hamada2, Jun-Ichiro Oka2
1Div. Med. Pharmacol., Inst. Natural Med., Univ. Toyama, 2Dept. Pharmacol., Fac. Pham. Sci., Tokyo Univ. Sci
Journal of Pharmacological Sciences 124 (suppl) 51-51, 2014.

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S3D-29-1 Pharmacological mechanisms in effects of opioid partial agonists

Soichiro Ide1, Masamichi Satoh2, Masabumi Minami1
1Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ, 2Grad. Sch. Pharm. Sci., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 52-52, 2014.

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S3D-29-2 Role of opioid systems in the differentiation potential of pluripotent stem cells

Naoko Kuzumaki1,2, Kohei Yamamizu3,4, Hideyuki Okano2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, 2Dept. Physiol., Keio Univ. Sch. Med, 3NIH, NIA, Developmental Genomics and Aging Section, Laboratory of Genetics, 4Laboratory of Stem cell Differentiation, Stem Cell Research Center, Institute for Frontier Medical Sciences, Kyoto University
Journal of Pharmacological Sciences 124 (suppl) 52-52, 2014.

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S3D-29-3 Optimizing the Clinical Efficacy of Opioids by TLR4 Blockade

Hang Hubert Yin
Dep. of Chem. and Biochem., BioFront. Inst., Univ. Colorado Boulder
Journal of Pharmacological Sciences 124 (suppl) 52-52, 2014.

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S3D-29-4 Functional Interaction between V1b Vasopressin and MOR1 Opioid Receptors Delays Development of Morphine Tolerance and Adenylate Cyclase Sensitization

Taka-aki Koshimizu1, Kenji Honda2, Yukio Takako2
1Div. Mol. Pharm., Jichi Med. Univ, 2Dep. Pharmacol. Fac. Pharmaceut. Sci. Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 52-52, 2014.

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S3E-30-1 Pharmacotherapy develepment targeted for altered decision-making in neuropsychiatric disorders

Hidehiko Takahashi
Dept. Psychiatry, Kyoto Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 53-53, 2014.

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S3E-30-2 Identification of therapeutic targets for psychiatric disorders using animal disease models

Hitoshi Hashimoto
Lab. of Mol. Neuropharmacol., Grad. Sch. of Pharmaceutical Sci., Osaka Univ, Mol. Res. Center for Children's Mental Dev., United Grad. Sch. of Child Dev., Osaka Univ, iPS Cell-based Res. Project on Brain Neuropharmacol. and Toxicol., Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 53-53, 2014.

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S3E-30-3 Dysfunction of GABAergic system in the insular cortex of an animal model for decision-making impairments

Kiyofumi Yamada1, Hiroyuki Mizoguchi2
1Dept. Neuropsychopharmacol. Host, Pharm., Nagoya Univ. Grad. Sch. Med, 2Futur. Environ. Simu. Cen., Res. Inst. Environ. Med., Nagoya Univ
Journal of Pharmacological Sciences 124 (suppl) 53-53, 2014.

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S3B-31-1 Small molecules promote neural differentiation from stem cells and protect against neuron insults

Yijia Lou, Zongfu Pan, Yihan Zhang
College of Pharmaceutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 54-54, 2014.

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S3B-31-2 DRAM1 regulates autophagy flux and Bid-mediated cell death via lysosomes

Zheng-Hong Qin
Department of Pharmacology, Soochow University School of Pharmaceutical Science
Journal of Pharmacological Sciences 124 (suppl) 54-54, 2014.

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S3B-31-3 Histamine H3 Receptor Aggravates Cerebral Ischemic Injury Independent of Histamine

Zhong Chen, Haijing Yan, Xiangnan Zhang, Weiwei Hu
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 54-54, 2014.

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S3B-31-4 Targeting nitrosative stress for neurovascular protection

Feng Han, Rong-rong Tao, Quan Jiang, Ying-mei Lu, Huan Wang
College of Pharmaceutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 54-54, 2014.

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S3D-32-1 Side effects of anticancer treatment and the needs of toxicity translational research: a clinician's perspective

Chikako Shimizu
Breast and Med. Onc. Division, Nat'l Cancer Center Hosp
Journal of Pharmacological Sciences 124 (suppl) 55-55, 2014.

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S3D-32-2 An innovative challenge to overcome stomatitis of cancer patients studied with stomatitis animal models

Kanako Miyano1, Suzuro Hitomi2, Atsushi Kaneko3, Kentaro Ono2, Toru Kono4,5, Kiyoshi Terawaki3, Seiji Shiraishi1, Yuji Omiya3, Kiyotoshi Inenaga2, Motohiro Matoba6, Yasuhito Uezono1
1Div. Cancer Pathophysiol., NCCRI, 2Div. Physiol., Kyushu Dental Univ, 3Tsumura Res. Lab., Tsumura & Co, 4Pathophysiol. Ther., Div. Pharm. Sci., Hokkaido Univ, 5Center Clin. Biomed. Res., Sapporo Higashi Tokushukai Hosp, 6Dept. Palliative Med., NCCH
Journal of Pharmacological Sciences 124 (suppl) 55-55, 2014.

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S3D-32-3 A promising treatment by a traditional Japanese medicine rikkunshito based on cancer cachexia pathophysiology

Kiyoshi Terawaki, Yuji Omiya, Yoshio Kase
Tsumura. Res. Lab., Tsumura & Co
Journal of Pharmacological Sciences 124 (suppl) 55-55, 2014.

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S3D-32-4 Improvement of bone cancer pain by antagonists of platelet-activating factor (PAF) receptor

Katsuya Morita1, Naoyo Motoyama2, Seiji Shiraishi3, Toshihiro Dohi4
1Dept. Pharmacol., Hiroshima Bunka Gakuen Univ, 2Dept. Dent. Sci. Health Promot., Hiroshima Univ. Inst. Biomed. & Health Sci, 3Div. Cancer Pathophysiol., Natl. Cancer Ctr. Res. Inst, 4Dept. Clinical Pharmacol., Nihon Pharmaceutical Univ
Journal of Pharmacological Sciences 124 (suppl) 55-55, 2014.

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S3E-33-1 Proteases and itch

Tsugunobu Andoh
Dept. Applied Pharmacol., Sch. Med. Pharm. Sci., Univ. Toyama
Journal of Pharmacological Sciences 124 (suppl) 56-56, 2014.

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S3E-33-2 Pruriceptive synaptic transmission in the spinal cord and descending modulatory system

Hidemasa Furue1,2, Daisuke Uta1
1Dept. Inf. Physiol., Nat. Inst. Physiol. Sci, 2Sch Life Sci., SOKENDAI
Journal of Pharmacological Sciences 124 (suppl) 56-56, 2014.

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S3E-33-3 Spinal mechanism for chronic itch

Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 56-56, 2014.

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S3E-33-4 Mechanism of itch in atopic dermatitis and treatment strategy

Junichi Hachisuka
Dept. Neurobiol., University of Pittsburgh
Journal of Pharmacological Sciences 124 (suppl) 56-56, 2014.

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S3A-34-1 Relaxin-3 Regulates Stress-Induced Alcohol-Seeking in Rats

Andrew J.Lawrence, Hanna Kastman, Phillip Ryan, Elena Krstew, Andrew L Gundlach
Florey Institute of Neuroscience & Mental Health, University of Melbourne
Journal of Pharmacological Sciences 124 (suppl) 57-57, 2014.

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S3A-34-2 Small molecule compounds with unique effects against immunoinflammation and their molecular targets

Qiang Xu
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences Nanjing University
Journal of Pharmacological Sciences 124 (suppl) 57-57, 2014.

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S3A-34-3 A novel antinociceptive peptide

Peter Tsun-Hon Wong
Department of Pharmacology, National University of Singapore, Block MD11, Clinical Research Centre
Journal of Pharmacological Sciences 124 (suppl) 57-57, 2014.

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S3A-34-4 Preventive and therapeutic effects of intravenously injected adipose -derived stem cells in Alzheimer's disease

Yoo-Hun Suh
KBRI (Korea Brain Research Institute)
Journal of Pharmacological Sciences 124 (suppl) 57-57, 2014.

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S3A-34-5 Melatonin promotes neural stem cell proliferation

Piyarat Govitrapong
Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Center for Neuroscience and Department of Pharmacology, Faculty of Science, Mahidol University
Journal of Pharmacological Sciences 124 (suppl) 58-58, 2014.

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S3A-34-6 The endoplasmic reticulum-oriented drug development for transthyretin familial amyloid polyneuropathy

Hirofumi Kai
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University
Journal of Pharmacological Sciences 124 (suppl) 58-58, 2014.

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S3B-35-1 Voltage-sensing phosphatases (VSPs) : from mechanisms to applications

Yasushi Okamura1, Souhei Sakata1,2, Hidekazu Tsutsui1,3
1Dept. Physiol., Osaka Univ. Sch. Med, 2Inst. Academic Initiatives, Osaka Univ, 3BSI, RIKEN
Journal of Pharmacological Sciences 124 (suppl) 59-59, 2014.

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S3B-35-2 PIP2-dependent regulation of K+ channel gating

Atsushi Inanobe
Dept. Pharmacol., Osaka Univ., Grad. Sch. of Med
Journal of Pharmacological Sciences 124 (suppl) 59-59, 2014.

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S3B-35-3 On the mechanism by which receptor activation modulates IKs channel -involvement of PIP2-

Kuniaki Ishii, Shingo Ohsima, Yoshinobu Nagasawa, Kazuya Kurakami, Ikuo Norota
Dept. Phamacol., Yamagata Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 59-59, 2014.

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S3B-35-4 Altered PIP2 sensitivity may underlie the arrhythmogenicity of mutant TRPM4 channel

Ryuji Inoue1, Yaopeng Hu1, Yasushi Okamura2, Masayuki Mori3
1Dpt. Physiol., Grad. Sch. Med. Sci., Fukuoka Univ, 2Lab. Integ. Physial., Dept. Physiol., Sch. Med., Osaka Univ, 3Dept. Synth. Biol.Chem., Sch. Engineer., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 59-59, 2014.

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S3C-36-1 The engineered thymidylate kinase/AZT axis offers efficient bystander cell killing for suicide gene therapy of Cancer

Takeya Sato
Dept. Molpharm., Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 60-60, 2014.

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S3C-36-2 Development of human iPS cell-derived mature cardiomyocytes: toward its practical application

Yasunari Kanda1, Min Li2, Tetsushi Furukawa2, Yuko Sekino1, Junko Kurokawa2
1Div. Pharmacol., NIHS, 2Dept. Bio-Informational Pharmacol., MRI, Tokyo Med. Dent. Univ
Journal of Pharmacological Sciences 124 (suppl) 60-60, 2014.

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S3C-36-3 Development of virosome-mediated cancer therapy

Yasufumi Kaneda
Grad. Sch. Medicine, Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 60-60, 2014.

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S3D-37-1 Dynamic system of maintaining homeostasis in blood pressure via interaction between brain, kidney, heart, and vascular

Takuya Kishi
Dept. Adv. Ther. Cardio. Dis., Kyushu Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 61-61, 2014.

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S3D-37-2 Mechanisms underlying dysfunction of retinal blood vessels in diabetic rats

Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 61-61, 2014.

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S3D-37-3 Vasodilation and perivascular adipose tissue in metabolic syndrome

Satomi Kagota, Kana Maruyama, Kazumasa Shinozuka
Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ
Journal of Pharmacological Sciences 124 (suppl) 61-61, 2014.

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S3D-37-4 Vascular effects of novel adipocytokines: implication for pathogenesis of obesity-related hypertension

Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 61-61, 2014.

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S3E-38-1 Wheat cell-free technology for production and functional analysis of membrane protein

Tatsuya Sawasaki
Proteo-Science Center, Ehime Univ
Journal of Pharmacological Sciences 124 (suppl) 62-62, 2014.

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S3E-38-2 Isotope labeling of proteins using cell-free synthesis and its application to structural dynamics analysis

Takanori Kigawa
RIKEN QBiC, RIKEN RINC, Interdisc. Grad. Sch. Sci. Eng., Tokyo Inst. Tech
Journal of Pharmacological Sciences 124 (suppl) 62-62, 2014.

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S3E-38-3 Positron Emitter Labeling of Proteins by Cell Free Protein Synthesis System

Shozo Furumoto
Cyclotron and R.I. Center, Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 62-62, 2014.

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S3E-38-4 Pharmacological analysis of GPCRs and ion channels synthesized using a wheat germ cell-free system with liposomes

Kazutaka Maeyama1, Shuan Liu1, eiji Arimitsu1, Tatsuya Sawasaki2
1Dept. Pharmacol., Ehime Univ. Grad. Sch. Med, 2Proteo-Science Center, Ehime Univ
Journal of Pharmacological Sciences 124 (suppl) 62-62, 2014.

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S3B-39-1 Clinical biomarkers in Alzheimer's disease

Katsutoshi Furukawa
Department of Geriatrics and Gerontology Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University
Journal of Pharmacological Sciences 124 (suppl) 63-63, 2014.

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S3B-39-2 Aβ imaging in Alzheimer's disease and other neurodegenerative conditions

Victor L.Villemagne1, Michelle T Fodero-Tavoletti1,2, Vincent Dore3, Colin L Masters2, Christopher C Rowe1
1Austin Health, Dept of Nuclear Medicine and Centre for PET, 2The Florey Institute of Neuroscience and Mental Health, University of Melbourne, 3The Australian eHealth Research Centre, CSIRO
Journal of Pharmacological Sciences 124 (suppl) 63-63, 2014.

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S3B-39-3 Relation between amyloid, brain atrophy and cognition

Gael Chetelat
INSEAM, Universite de Caen, EPHE, CHU de Caen, U1077, GIP Cyceron
Journal of Pharmacological Sciences 124 (suppl) 63-63, 2014.

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S3B-39-4 PET TAU imaging in Alzheimer's disease using 18F-THK5105 and 18F-THK5117

Nobuyuki Okamura1, Ryuichi Harada1, Shozo Furumoto2, Kazuhiko Yanai1,2, Hiroyuki Arai3, Yukitsuka Kudo4
1Department of Pharmacology, Tohoku University School of Medicine, 2Cyclotron and Radioisotope Center, Tohoku University, 3Institute of Development, Aging and Cancer, Tohoku University, 4Clinical Research, Innovation and Education Center, Tohoku University Hospital
Journal of Pharmacological Sciences 124 (suppl) 63-63, 2014.

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S3C-40-1 Molecular mechanisms of synapse pathology in ATR-X syndrome

Norifumi Shioda, Masahiro Sawai, Misaki Onozato, Kouya Yamaguchi, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 64-64, 2014.

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S3C-40-2 Molecular mechanism in Rett syndrome

Kunio Miyake
Dept. Epigenet. Med., Yamanashi Univ
Journal of Pharmacological Sciences 124 (suppl) 64-64, 2014.

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S3C-40-3 The roles of CDKL5, a causative gene for neurodevelopmental disorders with infantile spasms, in synaptic transmission, emotion and learning/memory

Kosuke Okuda1, Aya Watanabe1, Shizuka Kobayashi2, Toshiya Manabe2, Keizo Takao3, Tsuyoshi Miyakawa3, Masahiro Fukaya4, Hiroyuki Sakagami4, Masashi Mizuguchi1, Teruyuki Tanaka1
1Dept. Developmental Medical Sciences, Graduate Sch. Med., The Univ. of Tokyo, 2Div. Neuronal Network, Inst. Medical Science, The Univ. of Tokyo, 3Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Inst. Physiological Sciences, 4Dept. Anatomy, Kitasato Univ., Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 64-64, 2014.

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S3C-40-4 Phenotypic analysis of IL1RAPL1 knockout mice

Misato Yasumura1, Masayoshi Mishina2
1Liaison academy, Interdiscip Grad Sch of Med and Eng, Univ of Yamanashi, 2Brain Sci Lab, Res Org of Sci & Tech, Ritsumeikan Univ
Journal of Pharmacological Sciences 124 (suppl) 64-64, 2014.

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YS1E-1-1 NGF activates ERK5 in Ras and Rap1-independent manners and promotes neurite outgrowth and catecholamine biosynthesis

Yutaro Obara1,2,3, Philip Stork3, Beth Habecker3, Kuniaki Ishii1, Norimichi Nakahata2
1Dept. Pharmacol., Yamagata Univ. Sch. Med, 2Dept. Cell. Signal., Grad. Sch. Pharmaceut. Sci., Tohoku Univ, 3OHSU
Journal of Pharmacological Sciences 124 (suppl) 66-66, 2014.

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YS1E-1-2 Signaling pathways involved in angiogenesis

Shigetomo Fukuhara, Naoki Mochizuki
Dept. Cell Biol., NCVC
Journal of Pharmacological Sciences 124 (suppl) 66-66, 2014.

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YS1E-1-3 Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

Kazuhiro Aoki
Imaging Platform for Spatio-Temporal Information, Grad. Sch. Med., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 66-66, 2014.

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YS1E-1-4 Regulation of cardiovascular remodeling by oxidative modification of G proteins

Motohiro Nishida
Div. Cardiocirc. Signal., Okazaki Inst. Integr. Biosci. (Natl Inst. Physiol. Sci.)
Journal of Pharmacological Sciences 124 (suppl) 66-66, 2014.

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YS2E-2-1 The role of ion channel and regulation of intracellular Ca 2+ during osteoclast differentiation

Takuya Notomi, Yoichi Ezura, Masaki Noda
Dept. Molecular Pharmacol., Tokyo Med. and Dent. Univ
Journal of Pharmacological Sciences 124 (suppl) 67-67, 2014.

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YS2E-2-2 Mechanism of the development of autoimmune diseases by impaired store-operated calcium entry

Masatsugu Oh-hora1,2, Noriko Komatsu3, Anjana Rao4, Hiroshi Takayanagi3
1Div. of Molecular Immunology, Medical Institute of Bioregulation, Kyushu Univ, 2JST, PREST, 3Dept. of Cell signaling, Tokyo Medical and Dental Univ, 4Div. of Signaling and Gene Expression, LIAI
Journal of Pharmacological Sciences 124 (suppl) 67-67, 2014.

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YS2E-2-3 A therapeutic approach of the functional regulation of store-operated Ca2+ entry through CRAC in rheumatoid arthritis

Shuang Liu1, Kazutaka Maeyama1, Tatsuya Sawazaki3, Hiroyuki Takeda3, Hitoshi Hasegawa2, Miyuki Kuno4
1Dept. Phamacol., Ehime Univ. Graduate Sch. Med, 2Department of Internal Medicine I, Ehime Univ. Sch. Med, 3PROS, Ehime Univ, 4Department of Molecular and Cellular Physiology, Osaka City Univ. Graduate Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 67-67, 2014.

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YS2E-2-4 Biologic agents in the treatment of rheumatoid arthritis

Hitoshi Hasegawa
Hemat. Clin Immun. Infect Dis. Ehime Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 67-67, 2014.

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CS1C-1-1 Role of bioinformatics in research and development for psychiatric disorders

Yusuke Kuwahara, Tore Eriksson, Katsuki Tsuritani
Mol. Function & Pharmacol. Labs., Taisho Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 70-70, 2014.

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CS1C-1-2 In vitro pharmacology of antipsychotics at human dopamine D2 and D3 receptors

Yoshihiro Tadori, Hiroyuki Kobayashi
TADD. Otsuka Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 70-70, 2014.

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CS1C-1-3 The Mouse Socially-evoked Activity Task as a novel animal model of schizophrenia

Takuma Mihara1,2, Steven.J.Siegel2, Rosanna.M.Sobota2, Robert Lin2, Robert.E.Featherstone2
1Dept. Neuroscience, Pharmacological Research Lab., Drug Discovery Research, Astellas Pharma Inc, 2Translational Neuroscience Program, Dept. of Psychiatry, School of Medicine, University of Pennsylvania
Journal of Pharmacological Sciences 124 (suppl) 70-70, 2014.

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CS2C-2-1 Anti-Pruritus Effect of E6005, a Novel Topical Phosphodiesterase 4 Inhibitor, Ameliorated Atopic Dermatitis-like Symptoms in Mice Model

Naoto Ishii
Eisai Co., Ltd. KAN-PCU
Journal of Pharmacological Sciences 124 (suppl) 71-71, 2014.

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CS2C-2-2 Adaptation possibility of TLR4 inhibitor to various diseases

Naomi Kitamoto
Inflammation Drug Discovery Unit, Takada Pharmaceutical Company Ltd
Journal of Pharmacological Sciences 124 (suppl) 71-71, 2014.

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CS2C-2-3 Inhibition of STAT5-phosphorylation and Efficacy in a Rat Arthritis Model with ASP015K, a Novel Janus Kinase Inhibitor

Yasuyuki Higashi
Astellas Phama Inc., Pharmacology Research Labs
Journal of Pharmacological Sciences 124 (suppl) 71-71, 2014.

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CS2C-2-4 IL-6 in autoimmune diseases

Misato Hashizume
Chugai Pharmaceutical., Co., Ltd, Product Research Department
Journal of Pharmacological Sciences 124 (suppl) 71-71, 2014.

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CS3C-3-1 ER stress and β cell death <Therapeutic approaches targeting ER stress>

Takashi Hara1, Christine Oslowski3, Jana Mahadevan2, Fumihiko Urano2
1Cardiovascular-Metabolics Research Lab., Daiichi Sankyo Co., Ltd, 2Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, 3Program in Gene Function and Expression, University of Massachusetts Medical School
Journal of Pharmacological Sciences 124 (suppl) 72-72, 2014.

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CS3C-3-2 Discovery and development of a selective GPR40/FFAR1 agonist, Fasiglifam, for the treatment of type 2 diabetes

Yoshiyuki Tsujihata
Cardiovascular Metabolic Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited
Journal of Pharmacological Sciences 124 (suppl) 72-72, 2014.

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CS3C-3-3 New prospect of bile acid sequestrants as a novel therapy for metabolic disorders -research strategy utilizing clinical data-

Kanami Sugimoto
Pharmacology Research Laboratories II, Mitsubishi Tanabe Pharma Corporation
Journal of Pharmacological Sciences 124 (suppl) 72-72, 2014.

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CS3C-3-4 An approach for anti-fibrotic drug discovery in NAFLD/NASH

Masayuki Sudoh1, Masahiko Matsumoto2, Natsuko Hada1, Yoshiyuki Sakamaki2, Tsuneo Ito1, Akiko Uno2, Asao Katsume1
1Research Division, Chugai Pharmaceutical Co., Ltd, 2Chugai Research Institute for Medical Science Inc
Journal of Pharmacological Sciences 124 (suppl) 72-72, 2014.

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O1F-1-1 Molecular mechanism of monoamine transport by primary human astrocytes

Fumito Naganuma, Takeo Yoshikawa, Tadaho Nakamura, Tomomitsu Iida, Yamato Miura, Kazuhiko Yanai
Department of Pharmacology, Tohoku University Graduated School of Medicine
Journal of Pharmacological Sciences 124 (suppl) 74-74, 2014.

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O1F-1-2 In vivo Ca2+ imaging of vascular smooth muscle cells in cerebral cortex

Nami Kitajima1, Hiroshi Sekiya1, Kazunori Kanemaru1, Kenji Tanaka2, Masamitsu Iino1
1Dept. of Pharmacol., Grad. Sch. of Med., Univ. of Tokyo, 2Neuropsych, Keio Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 74-74, 2014.

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O1F-1-3 Astrocytic gap junctional networks suppress cellular damages in an in vitro model of ischemia

Takanori Shinotsuka, Masato Yasui, Mutsuo Nuriya
Dept. Pharmacol., Keio Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 74-74, 2014.

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O1F-1-4 Regulation of astroglial activation by N-myc downstream-regulated gene 2 (Ndrg2) after cortical stab injury

Mika Takarada-Iemata1, Dai Kezuka1, Toshiaki Takeichi2, Yasuko Kitao1, Osamu Hori1
1Dept. Neuroanat., Kanazawa Univ. Grad. Sch. Med. Sci, 2Dept. Legal Med., Kanazawa Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 74-74, 2014.

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O1F-1-5 The roles of histamine in mouse primary microglia

Tomomitsu Iida1,2, Takeo Yoshikawa1, Yuuta Asami1, Tadaho Nakamura1, Fumito Naganuma1, Yamato Miura1, Mohsen Attyeb1, Ren Iwata2, Kazuhiko Yanai1,2
1Dept. Pharmacol., Tohoku Univ. Sch. Med, 2CYRIC, Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 75-75, 2014.

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O1F-2-1 Repeated milnacipran ameliorates rats with elevated impulsivity

Iku Kimura1,2, Yu Ohmura1, Takayuki Yoshida1, Takeshi Izumi1, Mitsuhiro Yoshioka1
1Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med, 2Research Fellow of Japan Society for the Promortion of Science
Journal of Pharmacological Sciences 124 (suppl) 75-75, 2014.

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O1F-2-2 Disinhibition of infralimbic cortex - amygdala circuit in fear reappearance

Natsuko Imamura, Yuki Miura, Chie Teshirogi, Huilian Shen, Norio Matsuki, Hiroshi Nomura
Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 75-75, 2014.

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O1F-2-3 The possibility of prostaglandin E2 (PGE2) as a common molecule associated with vulnerability to neurodevelopmental disruptions

Hirotake Hida1, Akihiro Mouri1, Kentaro Mori1, Tomoyuki Furuyashiki2, Kiyofumi Yamada3, Norio Ozaki4, Shuh Narumiya2, Toshitaka Nabeshima5, Yukihiro Noda1
1Div Clin Sci. & Neuropsychopharm, Meijo Univ Sch Pharm, 2Medical Innovation Center, Kyoto Univ Sch Med, 3Dept Neuropsychopham & Hosp Pharm, Nagoya Univ Sch Med, 4Dept Psychiatry, Nagoya Univ Sch Med, 5Dept Rerio Pharmaceut care & Sci, Meijo Univ Sch Pharm
Journal of Pharmacological Sciences 124 (suppl) 75-75, 2014.

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O1F-2-4 Oral glutathione administration improves memory deficits following transient brain ischemia

Yasushi Yabuki, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 76-76, 2014.

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O1F-2-5 FABP3 regulates GABA signaling in cingulate cortical neurons

Yui Yamamoto1, Kohji Fukunaga2, Yuji Owada1
1Dept. Organ Anatomy, Yamaguchi Univ. Grad. Sch. Med, 2Dept. Pharmacology, Tohoku Univ. Grad. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 76-76, 2014.

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O1F-3-1 Development of novel serine racemase inhibitors

Ryogo Wada1,2, Jie Li1, Hiroaki Gouda3, Shuichi Hirono3, Mineyuki Mizuguchi2, Naoki Toyooka1, Hisashi Mori2
1Grad. Sch. Sci. & Eng., Univ. Toyama, 2Med. & Pharmaceuti. Sci., Univ. Toyama, 3Sch. Pharmacy., Univ. Kitasato
Journal of Pharmacological Sciences 124 (suppl) 76-76, 2014.

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O1F-3-2 Synthesis and secretion of insulin in rat hippocampal neuron

Takayuki Nemoto1, Fumiyo Toyoshima2, Toshihiko Yanagita1, Hiroshi Fujita1, Tomohiro Koshida3, Toyoaki Maruta3, Akira Sawaguchi2
1Dept. Pharmacol., Miyazaki Univ. Sch. Med, 2Dept. Anatomy, Ultrastructural Cell Biology, Miyazaki Univ. Sch. Med, 3Dept. Anesthesiology, Miyazaki Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 76-76, 2014.

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O1F-3-3 Possible involvement of histaminergic, dopaminergic and adrenergic functions in the central nervous system on olanzapine-induced hyperglycemia

Megumi Ikegami1, Hiroko Ikeda1, Mamiko Osada1, Atsuko Kamei2, Junzo Kamei1
1Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, 2Mine Pharmacy
Journal of Pharmacological Sciences 124 (suppl) 77-77, 2014.

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O1F-3-4 S-Mercuration of protein disulfide isomerase results in cell death via endoplasmic reticulum stress

Kousaku Okuda1, Kento Makino1, Tadashi Nishiya1, Yoshito Kumagai2, Takashi Uehara1
1Dept. Medicinal Pharmacol.., Grad. Sch. Med. Den. Pharmaceutical Sci., Okayama Univ, 2Biomed Sci., Grad. Sch. Comprehensive Human Sci., Univ. Tsukuba
Journal of Pharmacological Sciences 124 (suppl) 77-77, 2014.

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O1F-3-5 Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor

Norihito Oi1,2,3, Michiyuki Suzuki1,3, Taro Terauchi1, Masaki Tokunaga2, Yosuke Nakatani1,2,3, Noboru Ymamoto1, Toshimitsu Fukumura2, Ming-Rong Zhang2, tetsuya Suhara2,3, Makoto Higuchi2,3
1Tsukuba Research Laboratories, Eisai Co., Ltd, 2Molecular Imaging Center, NIBS, 3Graduate School of Medicine, Tohoku University
Journal of Pharmacological Sciences 124 (suppl) 77-77, 2014.

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O1F-4-1 Treatment of the cuprizone-induced demyelination with cPA or 2ccPA

Shinji Yamamoto1, yuuki kawamura3, Mari Gotoh2, Keisuke Yoshikawa1, Kimiko Murofushi2, Kei Maruyama1
1Dept. Pharmacol., Saitama Med Univ. Sch. Med, 2Graduate School of Humanities and Sciences, Department of Life Science, Ochanomizu Univ, 3Liberal Arts education., Saitama Med Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 77-77, 2014.

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O1F-4-2 Repulsive guidance molecule-a is expressed in Th17 cells and contributes to neuronal damage in experimental autoimmune encephalomyelitis

Shogo Tanabe, Toshihide Yamashita
Dept. Mol. Neurosci., Grad. Sch. of Med., Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 78-78, 2014.

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O1F-4-3 Protective effect of DDC on glutamate neurotoxicity in rat cortical cultures

Kazuya Taguchi1, Shodai Takemasa1, Yasuhiko Izumi1, Akinori Akaike1, 2, Toshiaki Kume1
1Dept. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ, 2Grad. Sch. Pharm. Sci., Nagoya Univ
Journal of Pharmacological Sciences 124 (suppl) 78-78, 2014.

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O1F-4-4 Induction of Oxidative stress by the "toxic conformer" is crucial for Aβ42

Naotaka Izuo1,2, Toshiaki Kume2, Kazuma Murakami3, Mizuho Sato3, Kazuhiro Irie3, Yasuhiko Izumi2, Akinori Akaike2,4, Koutaro Yokote1, Takahiko Shimizu1
1Dept. Adv. Aging Med., Grad. Sch. Med., Chiba Univ, 2Dept. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ, 3Div. Food Sci. Biotech., Grad. Sch. Agri., Kyoto Univ, 4Grad. Sch. Pharm. Sci., Nagoya Univ
Journal of Pharmacological Sciences 124 (suppl) 78-78, 2014.

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O1F-4-5 GAPDH aggregation induces mitochondrial dysfunction

Akihiro Kaneshige1, Takeya Kubo1, Masanori Itakura1, Mitsuaki Moriyama2, Yasu-Taka Azuma1, Hidemitsu Nakajima1, Tadayoshi Takeuchi1
1Lab. Vet. Pharmacol., Division of Vet. Sci., Grad. Sch. Life Env. Sci., Osaka Prefecture Univ, 2Lab. Integrative Physiology, Division of Vet. Sci., Grad. Sch. Life Env. Sci., Osaka Prefecture Univ
Journal of Pharmacological Sciences 124 (suppl) 78-78, 2014.

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O1F-5-1 A novel target for PD therapeutics: A c-Abl inhibitor improved striatal motor dysfunction in MPTP mice

Akie Tanabe1, Yukio Yamamura1, Jiro Kasahara1, Ryoma Morigaki2, Ryuji Kaji3, Satoshi Goto2
1Dept. Neurobiol. & Ther., Inst. Health Biosci., Grad. Sch. Pharm. Sci., Univ.Tokushima, 2Dept. Motor Neurosci. & Neurother, , Inst. Health Biosci., Grad. Sch. Med., Univ. Tokushima, 3Dept. Clin. Neurosci., Inst. Health Biosci., Grad. Sch. Med., Univ. Tokushima
Journal of Pharmacological Sciences 124 (suppl) 79-79, 2014.

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O1F-5-2 S-nitrosylation regulates mitochondrial quality control via activation of parkin

Akira Komatsubara1,2, Kentaro Ozawa2, Hiroto Kawafune1,2, Yuichi Tsuji2, Sho Cho2, Masanori Yoshizumi2
1Dept. Genom Drug Disc Sci., Kyoto Univ, 2Dept. Pharmacol., Nara Med Univ
Journal of Pharmacological Sciences 124 (suppl) 79-79, 2014.

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O1F-5-3 Novel actin-based regulatory mechanism of nigrostriatal dopaminergic function by V-1 in vitro and in vivo

Ichiro Kawahata1, Lai Yanxin1, Shiori Ohtaku1, Junichi Morita1, Shigeki Kato2, Akiko Tabuchi3, Mamoru Fukuchi3, Masaaki Tsuda3, Kazumasa Ohashi4, Kensaku Mizuno4, Yasuhiko Izumi5, Toshiaki Kume5, Akinori Akaike5, Yoshihisa Tomioka1, Chiho Sumi-Ichinose6, Kazunao Kondo6, Hiroshi Ichinose7, Kazuto Kobayashi2, Tohru Yamakuni1
1Dept. Pharmacol., Tohoku Uni, 2Dept. Med., Fukushima Med. Uni, 3Dept. Pharmacol., Toyama Uni, 4Dept. Sci., Tohoku Uni, 5Dept. Pharmacol., Kyoto Uni, 6Dept. Med., Fujita Health Uni, 7Dept. Life Sci., Titech
Journal of Pharmacological Sciences 124 (suppl) 79-79, 2014.

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O1F-5-4 Establishment of a new mouse model with accelerated phosphorylation of endogenous tau

Seiya Suzuki1, 2, Sosuke Yagishita2, Ayaka Sorimachi1, Maya Moriizumi1, Takeo Awaji2, Masahiko Suzuki1, 2, Kei Maruyama2
1Faculty of Health and Medical Care, Saitama Med. Univ, 2Dept. of Pharmacol., Faculty of Med., Saitama Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 79-79, 2014.

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O1F-5-5 Drinking 'hydrogen water' induces ghrelin secretion and protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice

Megumi Yamafuji1, Akio Matsumoto2,3,5, Tomoko Tachibana2, Yusaku Nakabeppu4,5, Mami Noda1,5, Haruaki Nakaya2
1Lab of Pathophysiol., Kyushu Univ. Grad. Sch. Pharmaceu. Sci, 2Dept. Pharmacol., Chiba Univ. Grad. Sch. Med, 3Div. Mol. Design., Kyushu Univ. Med. Inst. of Bioreg, 4Div. Neurofunc. Genomics., Kyushu Univ. Med. Inst. of Bioreg, 5Research Center for Nucleotide Pool., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 80-80, 2014.

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O1G-1-1 Electrophysiological analyses of neuropeptidergic transmissions within the dorsolateral bed nucleus of the stria terminalis

Tomoyuki Kaneko, Soichiro Ide, Taiki Hara, Katsuyuki Kaneda, Masabumi Minami
Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ
Journal of Pharmacological Sciences 124 (suppl) 80-80, 2014.

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O1G-1-2 Interplay of metabotropic adenosine and glutamate receptors regulates cerebellar synaptic plasticity

Yuji Kamikubo, Taku Kashiyama, Takashi Sakurai
Dept. Pharmacol., Juntendo Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 80-80, 2014.

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O1G-1-3 Rapid induction of NMDA-dependent plasticity on V1 direction selectivity in awake mice

Kenta Funayama1, Genki Minamisawa1,2, Nobuyoshi Matsumoto1, Norio Matsuki1, Yuji Ikegaya1
1Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, 2Dept. Neurosci., Johns Hopkins Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 80-80, 2014.

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O1G-1-4 Chronic cocaine exposure induces inhibitory synaptic plasticity in cholinergic neurons of the laterodorsal tegmental nucleus

Naofumi Taoka, Ryo Kurosawa, Masabumi Minami, Katsuyuki Kaneda
Dept. Pharmacol., Grad. Sch. Pharm. Sci., Hokkaido Univ
Journal of Pharmacological Sciences 124 (suppl) 81-81, 2014.

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O1G-1-5 URB937, a peripherally-restricted inhibitor of fatty acid amide hydrolase (FAAH), reduces prostaglandin E2 (PGE2)-induced hyperactivity of bladder mechanoafferent nerve fibers in rats

Naoki Aizawa1, Petter Hedlund2,3, Yukio Homma4, Yasuhiko Igawa1
1Dept. Continence Medicine, Tokyo Univ, 2Urol. Res. Insti., San Raffaele Univ, 3Dept. Clinical Pharmacol., Linkoping Univ, 4Dept. Urol., Tokyo Univ
Journal of Pharmacological Sciences 124 (suppl) 81-81, 2014.

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O1G-2-1 Direct evidences for a key role of macrophage specific molecule in nerve injury induced neuropathic pain

Yuka Kobayashi1, Norikazu Kiguchi1, Fumihiro Saika1, Yohji Fukazawa1,2, Shiroh Kishioka1
1Dept. Pharmacol., Wakayama Med. Univ, 2Dept. Anat., Kansai Univ. Health Sci
Journal of Pharmacological Sciences 124 (suppl) 81-81, 2014.

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O1G-2-2 Chronic itch requires STAT3-dependent reactive astrocytes in the spinal dorsal horn

Miho Shiratori1, Keisuke Koga1, Ayumi Hasegawa1, Honami Toyonaga1, Hideyuki Okano2, Jun Hachisuka3, Kazuhide Inoue1, Makoto Tsuda1
1Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ, 2Dept. Physiol., Sch. Med., Keio Univ, 3Dept. Dermatol., Grad. Sch. Med., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 81-81, 2014.

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O1G-2-3 Peripheral interleukin-4 suppresses inflammatory macrophages and neuropathic pain

Norikazu Kiguchi1, Yuka Kobayashi1, Fumihiro Saika1, Takehiko Maeda2, Shiroh Kishioka1
1Dept. Pharmacol., Wakayama Med. Univ, 2Dept. Pharmacol., Niigata Univ. Pharm. Applied Life Sci
Journal of Pharmacological Sciences 124 (suppl) 82-82, 2014.

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O1G-2-4 Involvement of Th1 cells in the transition of nerve injury-induced acute pain to a chronic state

Xinwen Zhang1,2, Zhou Wu1, Yoshinori Hayashi1, Hiroshi Nakanishi1,2
1Dept. Aging Sci. and Pharmacol. Sci., Kyushu Univ, 1Facl. of Dent. Sci., Department of Aging Science and Pharmacology, Faculty of Dental Sciences, Kyushu University, 2CREST, Japan Science and Technology Agency
Journal of Pharmacological Sciences 124 (suppl) 82-82, 2014.

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O1G-3-1 Gangliosides induce hyperalgesia via regulation of extracellular glutamate levels

Shun Watanabe1, Hideyoshi Higashi2, Mitsuo Tanabe1
1Lab. Pharmacol., Sch. Pharm., Kitasato Univ, 2Div. Glyco-Signal Res., Inst. Mol. Biomemb. and Glycobiol., Tohoku Pharmaceutical Univ
Journal of Pharmacological Sciences 124 (suppl) 82-82, 2014.

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O1G-3-2 Involvement of redox-sensitive TRPA1 in dysesthesia induced by transient hindlimb ischemia-reperfusion in mice

Kanako So1, Meng Zhao1, Saki Nakamura1, Hisashi Shirakawa1, Takayuki Nakagawa2, Shuji Kaneko1
1Dept. Mol. Pharmacol., Grad. Sch. Pharm. Sci., Kyoto Univ, 2Dept Pharm, Kyoto Univ Hosp, Fac. Med., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 82-82, 2014.

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O1G-3-3 Involvement of spinal glutamate in oxaliplatin-induced mechanical allodynia

Soichiro Ushio1, Shohei Mitsuyasu1, Nana Ozawa1, Yuko Ono1, Takehiro Kawashiri2, Satohiro Masuda1,2, Ryozo Oishi1,2, Nobuaki Egashira1,2
1Fac. Sch. Pharm. Sci., Kyushu Univ, 2Dept. Pharmacy, Kyushu Univ. Hosp
Journal of Pharmacological Sciences 124 (suppl) 83-83, 2014.

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O1G-3-4 Influence of the rearing environmental stress in early life on neuropathic pain

Takashi Nishinaka, Kazuo Nakamoto, Syogo Tokuyama
Dept. Clinic. Pharm., Fac. Pharmaceu. Sci., Kobe Gakuin Univ
Journal of Pharmacological Sciences 124 (suppl) 83-83, 2014.

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O1G-4-1 Analysis on mechanisms underlying the antidepressant effect of food-derived antioxidant ergothioneine

Takahiro Ishimoto, Noritaka Nakamichi, Keigo Nakayama, Yusuke Masuo, Yukio Kato
Fac. Pharm., Kanazawa Univ
Journal of Pharmacological Sciences 124 (suppl) 83-83, 2014.

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O1G-4-2 Optogenetic stimulation of dorsal raphe serotonergic neurons produces antidepressant-like effect in mice

Naoya Nishitani1, Kazuki Nagayasu1,2,3, Nozomi Asaoka1, Mayumi Yamashiro1, Hisashi Shirakawa1, Takayuki Nakagawa1, Shoji Kaneko1
1Dept. Mol. Pharmcol., Grad. Sch. Pharm. Sci., Kyoto Univ, 2Drug. Innov. Ctr, Grad. Sch. Pharm. Sci., Osaka Univ., Drug Innovation Center, Graduate School of Pharmaceutical Sciences, Osaka University, 3Lab. Mol. Neuropharm., Grad. Sch. Pharm. Sci., Osaka Univ., Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
Journal of Pharmacological Sciences 124 (suppl) 83-83, 2014.

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O1G-4-3 The possible involvement of hypothalamic peptides in feeding regulation by opioid systems

Chrismawan Ardianto1, Hiroko Ikeda1, Lizhe Yang1, Megumi Ikegami1, Hiroshi Nagase2, Junzo Kamei1
1Dept. Pathophysiol. Ther., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, 2International Institute for Integrative Sleep Medicine (WPI-IIIS), Univ. Tsukuba
Journal of Pharmacological Sciences 124 (suppl) 84-84, 2014.

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O1G-4-4 Effect of cannabinoids on locomotor activity in KO mice of lipocalin-type prostaglandin D synthase and adenosine A2A receptors as animal models of sleep/wake disorders

Nahoko Uchiyama1, Kosuke Aritake2, Yoshihiro Urade2
1NIHS, 2IIIS
Journal of Pharmacological Sciences 124 (suppl) 84-84, 2014.

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O1G-5-1 Selectivity of dilator actions of Ca2+ channel blockers for the isolated blood vessel and lower esophageal sphincter from rats

Shuhei Nozaki, Akane Ishiguro, Kaori Okamura, Akira Takahara
Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci., Toho Univ
Journal of Pharmacological Sciences 124 (suppl) 84-84, 2014.

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O1G-5-2 Roles of the prostaglandin I2-IP system in nonalcoholic steatohepatitis

Shima Kumei1,2,3, Yuhki Koh-ichi1,3, Fumiaki Kojima1,3, Hitoshi Kashiwagi1,3, Toshikatsu Okumura2, Shuh Narumiya3,4, Fumitaka Ushikubi1,3
1Dept. Pharmacol., Asahikawa Med. Univ, 2Dept. General med., Asahikawa Med. Univ, 3CREST, 4Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 84-84, 2014.

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O1G-5-3 Involvement of radixin in the alteration of small intestinal P-glycoprotein via RhoA signaling by etoposide treatment

Kobori Takuro, Shinichi Harada, Kazuo Nakamoto, Tokuyama Shogo
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ
Journal of Pharmacological Sciences 124 (suppl) 85-85, 2014.

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O1G-5-4 Transcriptome analysis using next generation sequencing on Novel cancer immunological tolerance model

Tomokazu Hirota1, Yasuhito Shimada1,2,3,4,5, Michiko Ariyoshi1, Junya Kuroyanagi1, Noriko Umemoto1,2, Yuhei Nishimura1,2,3,4,5, Toshio Tanaka1,2,3,4,5
1Dept. Pharmacogenomics., Mie Univ. Grad. Sch. Med, 2Dept. System Pharmacol., Mie Univ. Grad. Sch. Med, 3Mie Univ. Med. Zebra, 4Dept. Bioinfo., Mie Univ. Life Sci, 5Dept. Omics., Mie Univ. Indust. Tech.Innov
Journal of Pharmacological Sciences 124 (suppl) 85-85, 2014.

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O1G-5-5 Analysis of the host epigenetic responses to influenza virus infection -role of histone methylations in the pathogenesis of influenza -

Akihiko Nakaya, Seiki Fujiwara, Misako Higashiya, Ayumi Kadowaki, Keiji Kuba, Yumiko Imai
Dept. Biological Informatics and Experimental Therapeutics, Akita Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 85-85, 2014.

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O1H-1-1 Regulation of the basal activity of Cav1.2 cardiac L-type Ca2+ channels by casein kinase 2 α'β

Toshihide Kashihara, Tsutomu Nakada, Mitsuhiko Yamada
Dept. Mol. Pharmacol., Shinshu Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 85-85, 2014.

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O1H-1-2 A novel in vitro model for evaluating drug-induced QT prolongation using genetically modified human iPS-derived cardiomyocytes

Min Li1, Yasunari Kanda2, Takashi Ashihara3, Tetsuo Sasano1, Yuko Sekino2, Tetsushi Furukawa1, Junko Kurokawa1
1Dept. Bio-Bioinfo. Phamacol., MRI, TMDU, 2Div. Pharmacol., NIHS, 3Dept. Cardiovasuc. Resp. Med., Shiga Univ. of Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 86-86, 2014.

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O1H-1-3 Sigma-1 receptor stimulation improves NO-mediated aortic relaxation in pressure overload-induced vascular injury

Hideaki Tagashira1, Takayuki Matsumoto2, Kumiko Taguchi2, Tsuneo Kobayashi2, Kohji Fukunaga1
1Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci, 2Dept. Physiol. and Morphol., Hoshi Univ. Inst. Med. Chem
Journal of Pharmacological Sciences 124 (suppl) 86-86, 2014.

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O1H-1-4 Anti-inflammatory effects of statins and anti-malarial agents via endothelial ERK5 activation

Yuki Izawa-Ishizawa1,2, Nhat-Tu Le2, Yuichiro Takei3, Kyung-Sun Heo2, Hakjoo Lee2, Alan Smrcka4, Benjamin Miller4, Kyung-Ae Ko2, Sara Ture2, Craig Morrell2, Keigi Fujiwara2, Masashi Akaike5, Toshiaki Tamaki1, Jun-ichi Abe2
1Dept. Pharmacol., Inst. HBS., Univ. Tokushima, Grad. Sch. Med, 2Aab Cardiovasc. Res. Inst.and Dept. Med., Univ. Rochester, Sch. Med. and Dent, 3Dept. Calcified Tissue Biol., Hiroshima Univ. Inst. Biomed. Health Sci, 4HTS core, Univ. Rochester, Med. Cent., Sch. Med. and Dent, 5Dept. Cardiovasc. Med., Inst. HBS., Univ. Tokushima, Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 86-86, 2014.

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O1H-1-5 Inhibitory effect of drinking citrus fruits on vascular remodeling using cuff-placement model

Arika Ohnishi, Rie Asayama, Masaki Mogi, Hirotomo Nakaoka, Harumi Kan-no, Li-Juan Min, Jun Iwanami, Masatsugu Horiuchi
Dept. Mol. Cardiovasc. Biol. Pharmacol., Ehime Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 86-86, 2014.

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O1H-2-1 Excessive BIN1 expression results in adverse remodeling through cardiomyocyte death

Kota Tonegawa, Sachi Matsunami, Daisuke Tsuchiyama, Hiroyuki Nakayama, Yasushi Fujio
Lab. Clinical Science and Biomedicine, Osaka Univ., Grad Sch. Phermaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 87-87, 2014.

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O1H-2-2 The macrophage-specific overexpression of CD93 enhances phagocytosis and ameliorates cardiac fibrosis after myocardial infarction

Kana Takewaki, Tomomi Yamashita, Kaori Miyamoto, Tomomi Mohri, Hiroyuki Nakayama, Yasushi Fujio
Lab. Clinical Science and Biomedicine, Osaka Univ., Grad. Sch. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 87-87, 2014.

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O1H-2-3 Transcriptome Toxicology of Cardiac Dysfunction induced by Multi-Kinase Inhibitor Sorafenib

Miko Kawabata1,6, Noriko Umemoto1,2, Yuhei Nishimura1,2,3,4,5, Yasuhito Shimada1,2,3,4,5, Junya Kuroyanagi1, Beibei Chang1, Masayuki Miyabe6, Toshio Tanaka1,2,3,4,5
1Dept. Mol. and Cell. Pharmacol., Pharmacogeno. and Pharmacoinfor., Mie Univ. Grad. Sch. Med, 2Dept. System Pharmacol., Mie Univ. Grad. Sch. Med, 3Mie Univ. Med. Zebra. Res. Cent, 4Dept. Bioinfo. Mie Univ. Life Sci. Res. Cent, 5Dept. Omics Med., Mie Univ. Indu. Tech. Innov. Inst, 6Dept. Clin. Anesthe. Mie Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 87-87, 2014.

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O1H-2-4 The role of leukotriene B4 receptor 1 in myocardial infarction

Hiroaki Nishihara, Michio Nakaya, Kenji Watari, Hitoshi Kurose
Dept. Pharmacol. Toxicol., Grad. Sch. Pharm. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 87-87, 2014.

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O1H-2-5 Development of an Experimentally Useful Model of Spontaneous Myocardial Infarction: 2/3 Nephrectomized Triple Nitric Oxide Syntheses-Deficient Mouse

Uchida Taro1, Yumi Furuno2, Kumiko Arakaki3, Mika Kina1, haruaki Kubota1, Mayuko Sakanashi1, Toshihiro Matsuzaki1, Katsuhiko Noguchi1, Junko Nakasone1, Yusuke Ohya3, Nobuyuki Yanagihara4, Hiroaki Shimokawa5, Masahito Tamura2, Yutaka Otsuji2, Masato Tsutsui1
1Dept. Pharmacol., Grad. Sch. Med., Univ. of the Ryukyus, 22nd Dept. Int. Med., Sch. Med., Univ. Occup. Environ. Health, 33nd Dept. Int. Med., Grad. Sch. Med., Univ. of the Ryukyus, 4Dept. Pharmacol., Sch Med, Univ. Occup. Environ. Healthccup, 5Dept. Cardiol, Tohoku Univ. Grad Sch Med
Journal of Pharmacological Sciences 124 (suppl) 88-88, 2014.

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O1H-3-1 Molecular mechanisms underlying the agonistic effect of FPL 64176 on Cav1.2 Ca2+ channels

Simmon Gomi1,2, Toshihide Kashihara1, Tsutomu Nakada1, Mitsuhiko Yamada1
1Dept. Mol. Phramacol.. Shinshu Univ. Sch. Med, 2Dept. Cardiovasc. Med., Shinshu Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 88-88, 2014.

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O1H-3-2 Acute bradycardia caused by atrioventricular block can unmask proarrhythmic potential of the rabbit heart

Mihoko Hagiwara, Kazuhiro Takada, Seiji Shibuta, Akira Takahara
Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci., Toho Univ
Journal of Pharmacological Sciences 124 (suppl) 88-88, 2014.

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O1H-3-3 Na+/H+ Exchanger inhibitor augments the hyperosmolarity-induced vasocontraction by the enhanced actin polymerization

Tomoya Sasahara1, Katsutoshi Yayama1, Tsuyoshi Tahara2, Hiroshi Onoe2, Hiroshi Okamoto1
1Dept. Cardiovascu, pharmacol., Kobe Gakuin Univ, 2RIKEN CLST
Journal of Pharmacological Sciences 124 (suppl) 88-88, 2014.

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O1H-3-4 Functional couplinq of TRPC6 channel with Ca2+ -sensing receptor in pulmonary hypertension

Aya Yamamura1, Kikuo Tsukamoto1, Naoki Ohara1, Jason X.-J. Yuan2
1Dept. Pharmacy, Kinjo Gakuin Univ, 2Dept. Med., Univ. Illinois at Chicago
Journal of Pharmacological Sciences 124 (suppl) 89-89, 2014.

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O1H-3-5 Effect of ATP Sensitive Potassium Channel Blocker Glibenclamide on Post-Ischemic Damage in Ischemia-Reperfusion Injury in the Rat Testis

Shogo Shimizu1, Motoaki Saito2, Panagiota Tsounapi3, Takahiro Shimizu2, Shinji Matsunaga1, Michiyo Iguchi1, Masashi Honda3, Takehiro Sejima3, Atsushi Takenaka3, Shuhei Tomita1
1Div. Mole Pharmacol., Tottori Univ. Sch. Med, 2Dept. Pharmacol., Kochi Univ. Sch. Med, 3Div. Urology., Tottori Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 89-89, 2014.

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O1H-4-1 Interleukin-6 contributes to modulation of oxidative stress and apoptosis caused by cisplatin

Satoru Mitazaki1, Megumi Sudo1, Shigeyoshi Honma2, Miwako Suto3, Naho Kato3, Kouichi Hiraiwa3, Makoto Yoshida2, Sumiko Abe1
1Lab. forensic toxicol., Fac. Pharmacy, Takasaki University Health and Welfare, 2Lab. Pathophysiol., Fac. Pharmacy, Takasaki University Health and Welfare, 3Dept. Legal Med., Fukushima Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 89-89, 2014.

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O1H-4-2 Role of macrophage hypoxia-inducible factor -1 in the development of renal fibrosis in mice

Yu Tateishi1, Mayuko Oka2, Masayuki Shiota3, Yasukatsu Izumi3, Katsuyuki Miura1
1Appl. pharmacol. ther., Osaka city unit. Sch. Med, 2Grad. Sch. Life Enviro. Sci., Kyoto Pref. Univ, 3Dept. Pharmacol., Osaka city unit. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 89-89, 2014.

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O1H-4-3 Protective effect of celastrol, a heat shock protein 90 inhibitor on streptozotocin-induced diabetic nephropathy via suppressing protein kinase C-δ signaling

Yuko Baba, Hiroyuki Mizuguchi, Erika Izumi, Hiroyuki Fukui
Dept.Mol.Pharmacoi., Inst. of Health Biosi., Tokushima Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 90-90, 2014.

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O1H-4-4 Cryopreservation for the cell selection using ultra-quick freezing

Yasuhiro Kato, Takayuki Miyauchi, Youichiro Abe, Manami Tanaka, Masato Yasui
Dept. Pharmacol., Keio Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 90-90, 2014.

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O1H-4-5 Unbiased search for potential substrate for proteases

Miyuki Tanigawa, Yoshie Tawara-Hirata, Hideki Tamura, Sadao Shiosaka
Dept., Functional Neuroscience, Grad. Sch. of Biol. Sci., Nara Inst. of Sci. and Technol
Journal of Pharmacological Sciences 124 (suppl) 90-90, 2014.

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O1H-5-1 The possibility of PC-SOD as a therapeutic drug for COPD

Ken-ichiro Tanaka, Tohru Mizushima
Faculty of Pharmacy, Keio Univ
Journal of Pharmacological Sciences 124 (suppl) 90-90, 2014.

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O1H-5-2 Drug development for COPD by drug re-positioning strategy

Ken-ichiro Tanaka, Tohru Mizushima
Faculty of Pharmacy, Keio Univ
Journal of Pharmacological Sciences 124 (suppl) 91-91, 2014.

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O1H-5-3 Role of Dendritic Cells via COX-2 Derived PGE2-EP3 Signaling for Pre-metastatic Niche Formation in Lymph Node Metastasis on Lung Cancer

Fumihiro Ogawa1,2, Hideki Amano3, Koji Eshima4, Kanako Hosono1, Yukitoshi Satoh2, Shuh Narumiya5, Yuji Kumagai3, Masataka Majima1
1Dept. Molecular Pharmacol., Kitasato Univ. Graduate Sch. Med. Sci, 2Dept. thorac. Surg., Kitasato Univ. Sch. Med, 3Dept. Clin. Research Center, Kitasato Univ. Sch. Med, 4Dept. immun., Kitasato Univ. Sch. Med, 5Dept.Molecular Pharmacol., Kyoto Univ. Graduate Sch. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 91-91, 2014.

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O1H-5-4 Receptor for advanced glycation end products and lung injury

Yasuhisa Izushi1, Hidenori Wake1, Keyue Liu1, Kiyoshi Teshigawara1, Hideo K.Takahashi2, Shuji Mori3, Masahiro Nishibori1
1Dept. Pharmacol., Okayama Univ. Sch. Med, 2Dept. Pharmacol., Kinki Univ. Sch. Med, 3Shujitsu Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 91-91, 2014.

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O1H-5-5 TXA2 abrogates acute lung inflammation by disrupting vascular endothelial barrier

Daiki Horikami1, Koji Kobayashi2, Masatoshi Hori1, Hiroshi Ozaki1, Takahisa Murata2
1Dept. Vet. Pharnacol., Univ. Tokyo, 2Dept. Animal Radiol., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 91-91, 2014.

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O1I-1-1 Apelin protects retinal neuronal injury in a mouse model of glaucoma

Akihide Sumino, Yuki Ishimaru, Chihiro Morioka, Daiki Kajioka, Takumi Morita, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ
Journal of Pharmacological Sciences 124 (suppl) 92-92, 2014.

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O1I-1-2 Systems pharmacology of tacrine against neomycin-induced hair cell damage using zebrafish

Syota Sasagawa1, Yuhei Nishimura1,2,3,4,5, Takanori Kondo1, Noriko Umemoto1,3, Miko Kawabata1, Soichiro Murakami1, Beibei Zhang1, Yasuhito Shimoda1,2,3,4,5, Toshio Tanaka1,2,3,4,5
1Dept. of Molecular and Cellular Pharmaco, Pharmacogeno and Pharmacoinfo, Mie Univ. Grad. Sch. of Med, 2Mie Univ. Medical Zebrafish Res. Cent, 3Dept. of Systems Pharmaco., Mie Univ Grad. Sch. of Med, 4Dept of Omics Med., Mie Uni. Indust. Tech. Innova. Inst, 5Dept of Bioinfo. Mie Univ. Life Sci. Res. Cent
Journal of Pharmacological Sciences 124 (suppl) 92-92, 2014.

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O1I-1-3 Inner ear hair cell-specific Cdc42-KO mice demonstrate progressive hearing loss by impaired actin turnover in stereocilia and apical junctions

Takashi Nakamura1, Takehiko Ueyama1, Hirofumi Sakaguchi2, Akihiro Goto3, Shigefumi Morioka1, Shigenobu Yonemura4, Yasuo Hisa2, Michiyuki Matsuda3, Atsu Aiba5, Naoaki Satio1
1Lab. of Molecular Pharmacology, Biosignal Research Center, Kobe Univ, 2Dept. Otolaryngology-Head and Neck Surgery, Kyoto Prefectural Univ. of Medicine, 3Lab. of Bioimaging and Cell Signaling, Graduate School of Biostudies, Kyoto Univ, 4Electron Microscope Lab. Center for Developmental Biology, RIKEN, 5Lab. of Animal Resources, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, Tokyo Univ
Journal of Pharmacological Sciences 124 (suppl) 92-92, 2014.

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O1I-1-4 Imaging of Ca2+ dynamics within the endoplasmic reticulum and mitochondria using new GFP-based fluorescent Ca2+ indicators

Junji Suzuki1, Kazunori Kanemaru1, Kuniaki Ishii2, Masamichi Ohkura3, Yohei Okubo1, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo, 2Dept. Pharmacol., Grad. Sch. Med., Yamagata Univ, 3Brain Sci. Inst., Saitama Univ
Journal of Pharmacological Sciences 124 (suppl) 92-92, 2014.

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O1I-1-5 Hydrogen water alleviates detrusor overactivity associated with bladder outlet obstruction in rats

Nozomu Miyazaki1,3, Ken Aikawa2, Masanori Nomiya3, Osamu Yamaguchi3, Junko Kimura1
1Dept. Pharmacol., Sch. Med., Fukushima Med. Univ, 2Dept. Uro., Sch. Med., Fukushima Med. Univ, 3Divi. Bioeng. LUTD, Nihon Univ. Sch. Eng
Journal of Pharmacological Sciences 124 (suppl) 93-93, 2014.

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O1I-2-1 Cell signaling mechanism activated by endothelin-1 in rat skeletal muscle cells

Akimasa Hoshi, Takahiro Horinouchi, Takuya Harada, Tsunaki Higa, Tsunehito Higashi, Koji Terada, Yosuke Mai, Prabha Nepal, Mika Horiguchi, Chizuru Hatate, Soichi Miwa
Dept. Cell. Pharmacol., Hokkaido Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 93-93, 2014.

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O1I-2-2 PICK1 Regulates Osteoclastogenesis by Binding to Calcineurin B

Yuya Kamano1,2, Makio Saeki3, Hiroshi Egusa2, Hirofumi Yatani2, Yoshinori Kamisaki1
1Dept. Phamacol., Osaka Univ. Dent, 2Dept. Fixed-Pro., Osaka Univ. Dent, 3Dept. Dent-Pham., Niigata Univ. Dent
Journal of Pharmacological Sciences 124 (suppl) 93-93, 2014.

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O1I-2-3 Significance of AMPK in renal protective and metabolic actions of nitrite

Licht Miyamoto1,2, Megumi Yamane2, Yosuke Tomida2, Kazuya Takenokuma2, Keisuke Ishizawa2, Toshiaki Tamaki3, Koichiro Tsuchiya2
1Pharmacology and Physiological Sciences, Frontier Lab. for Pharm. Sci, Tokushima Univ, 2Medical Pharmacology, HBS, Tokushima Univ, 3Pharmacology, HBS, Tokushima Univ
Journal of Pharmacological Sciences 124 (suppl) 93-93, 2014.

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O1I-2-4 Investigation on relationship between inflammation-inducing factor HMGB1 and insulin resistance

ki Cyuu, Kiyoshi Teshigawara, Hidenori Wake, Katsuyaku Ryu, Masahiro Nishibori
Dept. Pharmacol., Okayama Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 94-94, 2014.

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O1I-2-5 Direct Stimulation of Angiotensin II Type 2 Receptor Inhibits Binge Eating Disorder in Diabetic Mice

Hirotomo Nakaoka, Masaki Mogi, Harumi Kan-no, Li-Juan Min, Jun Iwanami, Masatsugu Horiuchi
Dept. Mol. Cardiovasc. Biol. Pharmacol., Ehime Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 94-94, 2014.

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O1I-3-1 Neural differentiation potentials in human embryonic stem cell lines

Daigo Fukumoto1,2, Takuya Matsumoto2, Yohei Okada2, Hirofumi Suemori3, Norio Nakatsuji3, Takeshi Suzuki1, Wado Akamatsu2, Hideyuki Okano2
1Dept.Basic biological science., Keio Univ. Pharm, 2Dept. Physiology, .Keio Univ.Sch. Med, 3Institute for Frontier Medical Science. Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 94-94, 2014.

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O1I-3-2 Isolation of new supportive factor for survival of iPSC-derived dopaminergic neurons

Kaneyasu Nishimura, Jun Takahashi
Dept. Clinical Application, Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 94-94, 2014.

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O1I-3-3 Acceleration of bone regeneration by topical application of GSK-3 inhibitor

Masaki Arioka1, Fumi Takahashi1, Masanori Sasaki2, Toshiyuki Sasaguri1
1Dept. Clinical Pharmacol., Kyushu Univ, 2Dept. Oral-Maxillofacial surgery., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 95-95, 2014.

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O1I-3-4 Increase of Prolactin-like-peptide expression by SIRT1 knockdown or cellular aging

Risa Hashimoto1, Risa Kunimoto1,2, Kouhei Horimoto1,2, Masahiro Sato1,2, Toshiharu Yamashita2, Yoshiyuki Horio1
1Dept. Pharmacol., Sapporo Med. Univ, 2Dept. Dermatol. Sapporo Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 95-95, 2014.

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O1I-3-5 The impact of tissue taurine deficiency on senescence-related cell signaling pathway

Takashi Ito, Junichi Azuma
Dept. Pharmacy, Hyogo Univ. Health Science
Journal of Pharmacological Sciences 124 (suppl) 95-95, 2014.

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O1I-4-1 Involvement of cysteinyl leukotriene 2 receptors in airway allergic inflammation in mice

Daiki Yamakoshi1, Yuji Masuta1, yu Kajiwara1, Takamiti Kitano1, Akihiro Sawada1, Kouhei Kuroda1, Ryou Takahashi1, Tomohiko Sekioka2, Hirotaka Yamashita1,3, Naoki Inagaki1,3, Hiroyuki Tanaka1,3
1Lab. Pharmacol., Dept. Bioactive Mol., Gifu Pharm. Univ, 2ONO Pharma. Co. Ltd, 3United Grad. Sch. Drug Disc. Med. Inform. Sci., Gifu Univ
Journal of Pharmacological Sciences 124 (suppl) 95-95, 2014.

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O1I-4-2 EP4 receptor-associated protein (EPRAP) in macrophages protects against bleomycin-induced pulmonary inflammation in mice

Sei Higuchi1, Manabu Minami1,2, Masato Nakatsuji2, Risako Fujikawa2, Mika Yasui2, Toshinori Murayama1, Masayuki Yokode1,2
1Dept. Clin. Innov. Med. Inst. Adv. Clin. Trans. Sci. Kyoto Univ. Hosp, 2Dept. Clin. Innov. Med., Grad. Sch. of Med
Journal of Pharmacological Sciences 124 (suppl) 96-96, 2014.

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O1I-4-3 Involvement of cardiac fibroblasts in cardiac dysfunction in septic mice: regulatory role of MMP-9

Kimimasa Sakata1,2, Kengo Tomita1, Michinori Takasina1, Takahiro Imaizumi1, Takuya Sakamoto1, Wakana Ohasi1, Naoki Yoshimura2, Yuichi Hattori1
1Dept, of Mol. Med. Pharmacol., Grad. Sch. of Med. Pharm. Sci., Univ. Toyama, 2Dept. of Gen. thorac. cardiovasc. surg., Grad. Sch. of Med. Pharm. Sci., Univ. Toyama
Journal of Pharmacological Sciences 124 (suppl) 96-96, 2014.

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O1I-4-4 Molecular mechanism of PMA-induced up-regulation of interleukin-33 gene expression in Swiss 3T3 cells

Sayaka Yamamoto1, Hiroyuki Mizuguchi1, Kouki Matsui1, Takako Esu1, Yoshiaki Kitamura2, Takeshi Nabe3, Noriaki Takeda2, Hiroyuki Fukui1,4
1Dept. Mol. Pharmacol., Inst. of Health Biosi., The Univ. Tokushima Grad. Sch, 2Dept. Otorhinolaryngol. Communicative Neurosci., Inst. of Health Biosci., Tokushima Grad. Sch, 3Dept. Pharmacol., Kyoto Pharmaceutical Univ, 4Dept. Mol. Studies for Incurable Diseases, Inst. of Health Biosci., Tokushima Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 96-96, 2014.

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O1I-4-5 The effect of an oral challenge with wheat protein in mice sensitized percutaneously with hydrolyzed wheat protein

Takamichi Kitano1, Hirotaka Yamashita1,2, Reiko Adachi3, Reiko Tejima3, Yuma Fukutomi4, Kayoko Matunaga5, Naoki Inagaki1,2, Hiroyuki Tanaka1,2
1Lab. Pharmacol., Dept. Bioactive Mol., Gifu Pharm. Univ, 2United Grad. Sch. Drug Disc. Med. Inform. Sci., Gifu Univ, 3Div. Novel Foods Immunochem., Natl. Inst. Health Sci, 4Clin. Res. Center Allergy Rheumatology, Natl. Hosp. Org. Sagamihara Natl. Hosp, 5Dept. Derma., Fujita Health Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 96-96, 2014.

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O1I-5-1 A Cancer-targeting Ligand Strongly Enhances Infectivity and Cytotoxicity of Oncolytic Adenovirus in Human Pancreatic Cancer Specimens

Yuki Yamamoto1,2, Naoko Goto1, Kazuki Miura1,2, Yosei Rin1,2, Nobuyoshi Hiraoka3, Masatoshi Tagawa4, Kazunori Aoki1
1Div. of Gene Immune Med., Natl., Cancer Ctr. Res. Inst, 2Lab. of Oncology, Tokyo Univ. of Pharm. and Life Sciences, 3Div. of Mol. Pathol., Natl., Cancer Ctr. Res. Inst, 4Div. Pathol & Cell Ther., Chiba Cancer Ctr. Res. Inst
Journal of Pharmacological Sciences 124 (suppl) 97-97, 2014.

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O1I-5-2 Blockage of P-glycoprotein and ABCG2 sensitized to sunitinib in renal carcinoma cells

Hiromi Sato1, Sana Siddig1, Uzu Miaki1, Tatsuro Kashiba1, Keisuke Gushimiyagi2, Yuko Sekine2, Koichi Ueno1
1Dept. of Geriatric Pharmacology and Therapeutics, Grad. Sch. of Pharamaceut. Sci., Chiba Univ, 2Dept. of Practical Pharmacology, Grad. Sch. of Pharamaceut. Sci., Chiba Univ
Journal of Pharmacological Sciences 124 (suppl) 97-97, 2014.

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O1I-5-3 Mechanisms of tumor cell uptake of 4-borono-phenylalanine, a 10B carrier of boron neutron capture therapy, mediated by system L amino acid transporters

Printip Wongthai1, Kohei Hagiwara1, Yurika Miyoshi2, Pattama Wiriyasermkul1, Pornparn Kongpracha1, Noriyoshi Isozumi1, Ryuichi Ohgaki1, Kenjiro Tadagaki1, kenji Hamase2, Shushi Nagamori1, Yoshikatsu Kanai1
1Division of Bio-system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, 2Department of Pharmaceutical Health Care and Sciences, Faculty of Pharmaceutical Sciences
Journal of Pharmacological Sciences 124 (suppl) 97-97, 2014.

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O1I-5-4 Cancer Stem Cells targeting Chemotherapy in Head and Neck squamous cell carcinoma

Umemura Naoki1, Emika Ohkoshi1, Toshiyuki Nanbu1,2, Jyun Shimada2, Hiroshi Sakagami1
1Dept. Pharmacol., Meikai Univ.Sch. Dent, 2Dept. Oral surgery., Meikai Univ.Sch. Dent
Journal of Pharmacological Sciences 124 (suppl) 97-97, 2014.

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O1I-5-5 Vasoactive intestinal peptide inhibits cell proliferation in human hepatocellular carcinoma cells

Hara Masaki1, yuko Takeba2, Kenichiro Kawaguchi1, Minoru Watanabe3, Toshio Kumai1, Sachiko Takenoshita2, Yuki Ohta2, Naoki Matsumoto2
1Dept.Genomics, St.marianna Univ. Sch. Med, 2Dept.Pharmacol., St.marianna Univ. Sch. Med, 3Inst. Exp. Animals, St.marianna Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 98-98, 2014.

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O2F-1-1 Neuropeptide Y Y5 receptor localization in brain as "hard specificity criteria" established by antibody preabsorption using Y5 knockout mouse

Shin-ichi Murase, Tomohiro Shiiya, Hiroshi Higuchi
Div. Pharmacol., Niigata Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 98-98, 2014.

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O2F-1-2 A role for mDia, a Rho-regulated actin nucleator, in elevated anxiety induced by social isolation stress in mice

Yuichi Deguchi1, Masaya Harada1, Ryota Shinohara1, Michael Lazarus2, Yoan Cherasse2, Yoshihiro Urade2, Tomoyuki Furuyashiki1, Shuh Narumiya1
1Medical Innovation Center CREST, Kyoto Univ. Sch. Med, 2Dept. Molecular Behavioral Biology, Osaka Bioscience Institute
Journal of Pharmacological Sciences 124 (suppl) 98-98, 2014.

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O2F-1-3 Role of hypothalamic POMC neurons in anti-tumor immunity

Yoshihiko Tasaki1,3, Daigo Ikegami1, Akira Yamashita1, Masami Suzuki2, Yasuhito Uezono2, Kazunori Aoki3, Minoru Naruta1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, 2Div. of Cancer Pathophysiol, NCCRI, 3Div. Gene and Immune Medicine., NCCRI
Journal of Pharmacological Sciences 124 (suppl) 98-98, 2014.

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O2F-1-4 Abnormal synapse formation in the hippocampus of solute carrier octn1 gene knockout mice

Noritaka Nakamichi, Yuichi Tanaka, Takahiro Ishimoto, Hiroshi Hosotani, Yusuke Masuo, Yukio Kato
Fac. Pharm., Kanazawa Univ
Journal of Pharmacological Sciences 124 (suppl) 99-99, 2014.

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O2F-1-5 Optogenetical stimulation of mesolimbic dopaminergic pathway induces the multi-physiological actions

Moe Watanabe1, Daigo Ikegami1, Akira Yamashita1, Yoshihiko Tasaki1, Asami Hamada1, Michiko Narita1, Kazunori Aoki2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm, 2Div. Gene Immune Med., NCCRI
Journal of Pharmacological Sciences 124 (suppl) 99-99, 2014.

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O2F-2-1 Polysulfides are potential H2S-derived signaling molecules that activate TRPA1 channels in rat brain

Yuka Kimura1, Yoshinori Mikami2, Kimiko Osumi1, Mamiko Tsugane3, Jun-ichiro Oka4, Hideo Kimura1
1Dept. Mol. Pharmacol., National Inst. Neuroscience, NCNP, 2Dept. Pharmacol., Grad. Sch. Med., Univ. of Tokyo, 3Fclty. Sci. Eng., Chuo Univ, 4Dept. Pharmacy., Tokyo Univ. of Sci
Journal of Pharmacological Sciences 124 (suppl) 99-99, 2014.

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O2F-2-2 Hydrogen sulfide protects retina from light-induced degeneration

Hideo Kimura1, Yoshinori Mikami4, Norihiro Shibuya1, Yuka Kimura1, Noriyuki Nagahara2, Masahiro Yamada3
1Dept. Mol. Pharmcol., Natl. Inst. Neurosci., NCNP, 2Nippon Med Sch, 3Saitama Med Sch, 4Dept. Pharmcol. Facul. Med, Tokyo Univ
Journal of Pharmacological Sciences 124 (suppl) 99-99, 2014.

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O2F-2-3 The activation of glutamatergic neuronal transmission in the prelimbic, but not infralimbic, medial prefrontal cortex induces anxiety-like behaviors in mice

Masanori Ohashi1,2, Misa Yamada1, Satoshi Suzuki1,2, Mai Tsukagoshi1,2, Azusa Sugiyama1,2, Masatoshi Inagaki3, Jun-ichiro Oka2, Mitsuhiko Yamada1, Akiyoshi Saito1
1Dept. of Neuropsychopharmacology, National Inst. of Mental Health, National Center of Neurology and Psychiatry, 2Lab. of Pharmacol., Fac. of Pharm. Sci., Tokyo Univ. of Sci, 3Dept. of Neuropsychiatry., Okayama Univ. Hospital
Journal of Pharmacological Sciences 124 (suppl) 100-100, 2014.

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O2F-2-4 Involvement of Nitric oxide-induced calcium release in extinction of cerebellum-dependent motor learning

Sho Kakizawa1, Yasushi Kishimoto2, Taisuke Miyazaki3, Midori Tanaka1, Takashi Murayama4, Masahiko Watanabe3, Masamitsu Iino5, Hiroshi Takeshima1
1Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ, 2Dept. Biophysics, Kagawa Sch. Pharmaceu. Sci., Tokushima Burni Univ, 3Dept. Anat., Grad. Sch. Med., Hokkaido Univ, 4Dept. Pharmacol., Juntendo Univ., Sch. Med, 5Dept. Pharmacol., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 100-100, 2014.

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O2F-2-5 mTOR is involved in both kinase activity-dependent and -independent pathways of DGKβ-regulated neurite and branch induction

Takuya Kano1, Hiroko Nakai1, Akio Nakashima2, Ushio Kikkawa2, Naoaki Saito2, Nobuyuki Takei3, Shuji Ueda1, Minoru Yamanoue1, Yasuhito Shirai1
1Dept. Applied Chemistry in Bioscience, Grad. Sch. of Agri., Kobe Univ, 2Biosignal Res Ctr, Kobe Univ, 3Dep. Mol. Neurobiol. Brain Res Inst, Niigata Univ
Journal of Pharmacological Sciences 124 (suppl) 100-100, 2014.

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O2F-3-1 Possibility of a novel therapy for neuropathic pain by specific histone modification of astrocytic chemokines in the spinal cord

Daigo Ikegami1, Kaori Ohi1, Michiko Narita1, Akira Yamashita1, Naoko Kuzumaki2, Hideyuki Okano2, Toshikazu Ushijima3, Minoru Narita1
1Dept. of Pharmacol., Hoshi Univ, 2Dept. Physiol., Keio Univ. Sch. Med, 3Div. of Epigenomics, NCCRI
Journal of Pharmacological Sciences 124 (suppl) 100-100, 2014.

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O2F-3-2 Antinociceptive effect of narcotic analgesics against mechanical allodynia in inflammatory pain state

Yuta Aoki, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
Dept. Physiol. Anat. Tohoku Pharmaceut. Univ
Journal of Pharmacological Sciences 124 (suppl) 101-101, 2014.

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O2F-3-3 Micro-RNA 200b/429 in the nucleus accumbens plays a key role in the neuropathic pain

Asami Hamada1,2, Akira Yamashita1, Yuki Suhara1, Michiko Narita1, Jun Tsuyama2, Naoko Kuzumaki2, Hideyuki Okano2, Minoru Narita1,2
1Dept.Pharmacol., Hoshi Univ. Sch. Pharm, 2Dept. Physiol., Keio Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 101-101, 2014.

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O2F-3-4 Down regulation of zinc transporter 1 induces neuropathic pain via BDNF-KCC2 signaling pathway in spinal cord

Tomoya Kitayama1, Katsuya Morita2, Takashi Kanematsu1
1Dept. Cell & Molecular Pharmacol., Hiroshima Univ. Institute Biome. & Health Sci, 2Dept. Pharmacol., Hiroshima Bunka Gakuen Univ
Journal of Pharmacological Sciences 124 (suppl) 101-101, 2014.

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O2F-3-5 Preventive or therapeutic effects of anti-HMGB1 neutralizing antibody and recombinant human soluble thrombomodulin in rats with neuropathy induced by vincristine

Takeshi Nishida1,2, Yudai Kawaishi1, Hiroki Yamanishi1, Maho Tsubota1, Fumiko Sekiguchi1, Hiroyasu Ishikura2, Masahiro Nishibori3, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm, 2Dept. Emerg. Crit. Care Med., Fac. Med., Fukuoka Univ, 3Dept. Pharmacol., Okayama Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 101-101, 2014.

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O2F-4-1 The role of histamine H3 receptor in pancreatic a-cells

Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Tomomitsu Iida, Yamato Miura, Attayeb Mohsen, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 102-102, 2014.

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O2F-4-2 Osteocalcin induces release of glucagon-like peptide-1 and improves metabolic state in mice

Akiko Mizokami1, Hiroshi Takeuchi2, Masato Hirata1
1Lab. Mol. Cell. Biochem. Fac. Dental. Sci., Kyushu Univ, 2Div. Appl. Pharmacol. Kyushu Dental Univ
Journal of Pharmacological Sciences 124 (suppl) 102-102, 2014.

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O2F-4-3 Host energy regulation by short-chain fatty acids receptors through diet and gut microbiota

Ikuo Kimura, Gozoh Tsujimoto
Dept. Pharmgenomics., Grad. Sch. Pharm. Sci., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 102-102, 2014.

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O2F-4-4 SMAD2 disruption in mouse pancreatic β-cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of KATP channel activity

Noriyoshi Teramoto1, Masatoshi Nomura2
1Dept. Pharmacol., Faculty of Medicine, Saga Univ, 2Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Journal of Pharmacological Sciences 124 (suppl) 102-102, 2014.

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O2F-4-5 Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes

Mitsuhiro Okamoto, Mami Yamaoka, Tomomi Ando, Takeshi Terabayashi, Masahiro Takei, Ichiro Niki, Toshimasa Ishizaki, Toshihide Kimura
Dept. Pharmacol., Oita Univ. Faculty of Med
Journal of Pharmacological Sciences 124 (suppl) 103-103, 2014.

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O2F-5-1 Dietary induction of skin barrier dysfunction and itch-related scratching in hairless mice: a unique tool for studying atopic dermatitis

Masanori Fujii, Yuki Shimazaki, Takashi Taruki, Minako Tanaka, Wakako Hayashi, Shintaro Miyake, Takeshi Nabe, Susumu Ohya
Dept. Pharmacol., Kyoto Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 103-103, 2014.

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O2F-5-2 Decrease in the expression of Sprouty/Spred family in TNCB-induced contact dermatitis

Ken Sato1, Hiroyasu Sakai1, Yuka Inoue1, Yoshihiko Chiba2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm, 2Dept. Biol., Hoshi Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 103-103, 2014.

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O2F-5-3 Glycogen Synthase Kinase-3 beta differentially modifies early and late stages of adipogenesis from the pluripotent stem cells to mature adipocytes

Takeshi Imamura, Hirotaka Iwasaki, Masashi Tawa, Takashi Shimosato, Tomio Okamura
Dept. Med., Shiga Univ. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 103-103, 2014.

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O2F-5-4 Cross-species transcriptome analyses discovered MXD3 regulation in visceral adiposity

Yasuhito Shimada1,2,3,4,5, Michiko Ariyoshi1, Tomokazu Hirota1, Junya Kuroyanagi1, Noriko Umemoto1,2, Yuhei Nishimura1,2,3,4,5, Toshio Tanaka1,2,3,4,5
1Dept. Pharmacogenomics., Mie Univ. Grad. Sch. Med, 2Dept. System Pharmacol., Mie Univ. Grad. Sch. Med, 3Mie Univ. Med. Zebra, 4Dept. Bioinfo., Mie Univ. Life Sci, 5Dept. Omics., Mie Univ. Indust. Tech.Innov
Journal of Pharmacological Sciences 124 (suppl) 104-104, 2014.

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O2G-1-1 Angiotensin II decreases bradykinin-induced NO and increases prostaglandin F2α release from cultured Microminipig basilar arterial endothelial cells

Md.Zahorul Islam1, Emi Yamazaki-Himeno1, Mitsuya Shiraishi1, Atsushi Miyamoto1, Hiroaki Kawaguchi2, Noriaki Miyoshi2, Naoki Miura3, Akihide Tanimoto4
1Dept. Vet. Pharmacol., Kagoshima Univ, 2Lab. of Vet. Histopathol., Kagoshima Univ, 3Vet. Teaching Hospital, Kagoshima Univ, 4Dept. Mol. and Cell. Pathol., Grad. Sch. Med. and Dent. Sci., Kagoshima Univ
Journal of Pharmacological Sciences 124 (suppl) 104-104, 2014.

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O2G-1-2 The hypotensive effect of azilsartan through angiotensin converting enzyme 2/angiotensin-(1-7)/Mas axis activation

Jun Iwanami, Masaki Mogi, Xiao-Li Wang, Kana Tsukuda, Hirotomo Nakaoka, Kousei Ohshima, Toshiyuki Chisaka, Hui-Yu Bai, Harumi Kan-no, Li-Juan Min, Masatsugu Horiuchi
Dept. Mol. Cardiovasc. Biol. Pharmacol., Ehime Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 104-104, 2014.

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O2G-1-3 A protective role of NOX1/NADPH oxidase in a mouse model with hypoxia-induced sinus bradycardia

Akiteru Kojima1, 2, Hirofumi Nishida1, Akio Matsumoto1, Kazumi Iwata3, Takeshi Shirayama2, Chihiro Yabe-Nishimura3, Haruaki Nakaya1
1Dept. Pharmacol., Chiba Univ. Grad. Sch. Med, 2Dept. Cardio. Med., Kyoto Pref. Univ. Med, 3Dept. Pharmacol., Kyoto Pref. Univ. Med
Journal of Pharmacological Sciences 124 (suppl) 104-104, 2014.

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O2G-1-4 NF-kB as a critical factor for intracranial aneurysm formation and as a therapeutic target for treatment

Tomohiro Aoki1, Miyuki Fukuda1,3, Yayoi Yoshimura2, Keiichi Tsuji2, Kazuhiko Nozaki2, Shuh Narumiya1
1AK project, Department of Medicine, Kyoto University Graduate School of Medicine, 2Department of Neurosurgery, Shiga University of Medical Science, 3Department of Neurosurgery, Kyoto Universtiy Graduate School of Medicne
Journal of Pharmacological Sciences 124 (suppl) 105-105, 2014.

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O2G-1-5 The molecular mechanisms underlying NOX1/NADPH oxidase-mediated apoptosis in pulmonary arterial smooth muscle cells

Kazumi Iwata, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Prefectural Univ. Med
Journal of Pharmacological Sciences 124 (suppl) 105-105, 2014.

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O2G-2-1 Cardiovascular Effects of Renal Symphathetic Denervation on the Chronic Atrioventricular Block Dogs: Comparison with Those of Cilnidipine and Amiodarone

Hiroshi Ohara1,4, Yuji Nakamura1, Xin Cao1, Hirofumi Yokoyama1, Hiroko Izumi-Nakaseko1, Kentaro Ando1, Nobuyuki Murakoshi2, Akira Sato2, Kazutaka Aonuma2, Akira Takahara3, Takanori Ikeda4, Atsushi Sugiyama1
1Dept. Pharmacol., Fclt. Med., Toho Univ, 2Cardiovasc. Div., Graduate School of Comprehensive Human Sci., Univ. of Tsukuba, 3Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci., Toho Univ, 4Div. of Cardiovasc. Med., Dept. of Internal Med., Toho Univ., Faculty of Med
Journal of Pharmacological Sciences 124 (suppl) 105-105, 2014.

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O2G-2-2 The Ca2+ sensitizer levosimendan mitigates septic inflammation

Hiroki Yokoo, Qiang Wang, Lobna A. Abdelzaher, Michinori Takashina, Wakana Ohashi, Kimimasa Sakata, Takahiro Imaizumi, Takuya Sakamoto, Yuichi Hattori
Dept. Mol. Med. Pharmacol., Grad. Sch. Med. Pharmaceu.Sci., Univ. Toyama
Journal of Pharmacological Sciences 124 (suppl) 105-105, 2014.

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O2G-2-3 The impairment of σ1 receptor by haloperidol promotes the progression of heart failure

Yasuharu Shinoda, Hideaki Tagashira, Kohji Fukunaga
Dept. Pharmacol., Grad. Sch. of Pharm. Sci., Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 106-106, 2014.

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O2G-2-4 A network of Apelin and ACE2 regulates cardiac contractility in failing hearts

Teruki Sato, Keiji Kuba, Takashi Suzuki, Ayumi Kadowaki, Yumiko Imai
Dept. Biol. Info. & Exp. Ther., Akita Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 106-106, 2014.

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O2G-2-5 Effect of pimobendan on heart failure at different stages in a mouse model of inherited cardiomyopathy

Miki Nonaka, Sachio Morimoto, Kengo Hayamizu, Toshiyuki Sasaguri
Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 106-106, 2014.

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O2G-3-1 Possible involvement of PIP2 in KCNQ1/KCNE1 current inhibition by insulin

Shingo Ohshima, Yoshinobu Nagasawa, Minghua Wu, Norota Ikuo, Kuniaki Ishii
Dept. Pharmacol., Yamagata Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 106-106, 2014.

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O2G-3-2 Assessment of Testing Methods for Evaluating Drug-Induced Repolarization Delay with iPS-Derived Cardiomyocyte Sheet: Multisite Validation Study

Yuji Nakamura1, Junko Matsuo1,2,3, Norimasa Miyamoto4, Atsuko Ojima4, Kentaro Ando1, Yasunari Kanda2, Kohei Sawada4, Atsushi Sugiayama1, Yuko Sekino2
1Dept. Pharmacol., Fclt. Med., Toho Univ, 2Div. Pharmacol., NIHS, 3SNBL DSR, 4Global CV Assessment, BA-CFU Eisai Co.Ltd
Journal of Pharmacological Sciences 124 (suppl) 107-107, 2014.

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O2G-3-3 Developmental increase in sarcoplasmic reticulum (SR) dependency of excitation-contraction (E-C) mechanisms in the mouse ventricular myocardium

Shogo Hamaguchi, Yuko Kawakami, Yoriko Honda, Kana Nemoto, Ayaka Sano, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 107-107, 2014.

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O2G-3-4 Pseudo QT-interval Prolongation Induced by ST-segment Depression

Kentaro Ando1, Yuji Nakamura1, Kiyotaka Hoshiai1, Xin Cao1, Hiroshi Ohara1, Hiroko Izumi-Nakaseko1, Akira Takahara2, Atsushi Sugiyama1
1Dept. Pharmacol., Fclt. Med., Toho Univ, 2Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci., Toho Univ
Journal of Pharmacological Sciences 124 (suppl) 107-107, 2014.

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O2G-3-5 Isoproterenol-induced cardiac fibrosis in Tric-a-knockout mice

Daiju Yamazaki, ChengZhu Zhao, ShengChen Tao, ChaoHong Wang, Miyuki Nishi, Hiroshi Takeshima
Dept. Biol. Chem., Grad. Sch. of Pharmaceut. Sci., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 107-107, 2014.

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O2G-4-1 Increased expression of peptide YY and GLP-1 in the colon of 5-FU-induced mice lacking appetite

Kazuhide Takase, Hiroyasu Sakai, Atsunobu Sagara, Akiko Hirosaki, Ara Jo, Ryoto Sugiyama, Ken Sato, Minoru Narita
Dept. Pharmacol., Hoshi Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 108-108, 2014.

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O2G-4-2 Na+/Ca2+ exchanger 2-heterozygote knockout mice display increased relaxation in gastric fundus

Satomi Hayashi1, Yasu-Taka Azuma1, Satomi Kita2, Hidemitsu Nakajima1, Takahiro Iwamoto2, Tadayoshi Takeuchi1
1Lab. Vet. Pharmacol., Division of Vet. Sci., Grad. Sch. Life Env. Sci., Osaka Prefecture Univ, 2Dep. Pharmacol., Facul. Med., Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 108-108, 2014.

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O2G-4-3 Nrf2-induceding anti-oxidation stress response in the liver - New beneficial effect of Lansoprazole

Takashi Ueyama1, Yasunobu Yamashita2, Toshio Nishi1, Yuta Yamamoto1, Hideyuki Tamai2, Takao Ito1, Yoshihiro Tsuruo1, Masao Ichinose2
1Dept.Anat.Cell Biol., Wakayama Med. Univ.Sch.Med, 22nd Dep.Internal Med., Wakayama Med. Univ.Sch.Med
Journal of Pharmacological Sciences 124 (suppl) 108-108, 2014.

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O2G-4-4 Generation of an inhibitory antibody against claudin-15 for modulation of the intestinal barrier function

Kazumasa Moriwaki1, Michio Asahi1, Mikio Furuse2
1Dept. Pharmacology., Med., Osaka Medial College, 2Dept. Physiology and Cell Biology, Grd. Sch. Med., Kobe Univ
Journal of Pharmacological Sciences 124 (suppl) 108-108, 2014.

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O2G-4-5 Role of neutrophil elastase in 5-fluorouracil-induced diarrhea of the mouse

Atsunobu Sagara1, Hiroyasu Sakai1, Kenjiro Matsumoto1,2, Akiko Hirosaki1, Ara Jo1, Ryoto Sugiyama1, Kazuhide Takase1, Ken Sato1, Daigo Ikegami1, Shunji Horie2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm, 2Dept. Pharmacol., Josai Int. Univ
Journal of Pharmacological Sciences 124 (suppl) 109-109, 2014.

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O2G-5-1 Overactive bladder mediated by accelerated Ca2+ influx mode of Na+/Ca2+ exchanger in smooth muscle

Hisao Yamamura1, William C.Cole2, Satomi Kita3, Shingo Hotta1, Hidemitchi Murata1, Yoshiaki Suzuki1, Susumu Ohya1,4, Takahiro Iwamoto3, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceuti. Sci., Nagoya City Univ, 2Dept. Physiol. & Pharmacol., Fac. Med., Univ. Calgary, 3Dept. Pharmacol., Fac. Med., Fukuoka Univ, 4Dept. Pharmacol., Kyoto Pharmaceut. Univ
Journal of Pharmacological Sciences 124 (suppl) 109-109, 2014.

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O2G-5-2 Distigmine (Dis) shows a long-lasting potentiation of guinea-pig urinary bladder (GPUB) contractile functions with inhibiting cholinesterase (ChE) activity independently of its plasma concentration

Keisuke Obara, Aya Katayose, Eriko Kaneki, Kyosuke Sato, Daisuke Chino, Yoshio Tanaka
Dept. Chem. Pharmacol., Toho Univ. Sch. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 109-109, 2014.

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O2G-5-3 Intracellular Ca2+ regulation analysis in mice non-pregnant and pregnant myometrial smooth muscle cells

Katsuhito Matsuki1, Masashi Takemoto1, Yoshiaki Suzuki1, Susumu Ohya1,2, Hiroshi Takeshima3, Yuji Imaizumi1
1Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmceut. Sci., Nagoya City Univ, 2Dept. Pharmacol., Kyoto pharm. Univ, 3Dept. Biol. Chem., Grad. Sch. Pharmceut. Sci, Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 109-109, 2014.

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O2G-5-4 Effects of Lactobacillus gasseri OLL2809 on the mouse and rat endometriosis models

Masayuki Uchida, Toshihiro Sashihara, Orie Kobayashi, Asako Satoh, Hiroyuki Itoh
Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 110-110, 2014.

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O2H-1-1 The inhibitory effect of histamine on high mobility group box 1 activity via the cAMP/PKA pathway

Shinichi Hamasaki1,2, Atsuko Niwa2, Hiroshi Ueno2, Masahiro Nishibori3, Hideo Takahashi2
1Dept.Anesth., Kinki Univ.Sch.Med, 2Dept.Pharmacol., Kinki Univ.Sch.Med, 3Dept.Pharmacol., Okayama Univ.Sch.Med
Journal of Pharmacological Sciences 124 (suppl) 110-110, 2014.

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O2H-1-2 In vitro study of proliferation of bone marrow-derived mast cells

Nobuyuki Fukuishi, Tomoyo Kunimi, Syouhei Rokuda, Masaaki Akagi
Dept. Pharmacol., Fac. Pharmac. Sci., Tokushima Bunri Univ
Journal of Pharmacological Sciences 124 (suppl) 110-110, 2014.

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O2H-1-3 Actin nucleator, mDia1 and mDia3, cooperatively function in T cell receptor signaling-dependent T cell development in thymus

Dean Thumkeo1,2, Akira Nomachi2, Kiyoshi Tohyama1, Takako Hirata1,2, Toshimasa Ishizaki1, Shuh Narumiya1,2
1Dept. Pharm, Kyoto Univ. Grad. Sch. Med, 2AK project, Kyoto Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 110-110, 2014.

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O2H-1-4 Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate but down-regulate with multinucleated formation

Koreaki Sugimoto1, Hyunmi Choi1, Masaru Tanaka2
1Dept. Psychosomatic and oral med., Kansei Fukushi Res. Center, Tohoku Fukushi Univ, 2Dept. Biochemical Engineering, Biomaterials Sci. Group, Graduate School of Sci. and Engineering, Yamagata Univ
Journal of Pharmacological Sciences 124 (suppl) 111-111, 2014.

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O2H-1-5 Pharmacological analysis of membrane protein receptors synthesized using a wheat germ cell-free system with liposomes

Eiji Arimitsu1,2, Tomio Ogasawara3, Hiroyuki Takeda3, Yoich Hiasa2, Tatsuya Sawasaki3, Kazutakaa Maeyama1
1Dept. Pharmacol., Ehime Univ. Sch. Med, 2Dept. Gastroenterology and Metabology., Ehime Univ. Sch. Med, 3Cell-free Science and technology Research Center., Ehime University
Journal of Pharmacological Sciences 124 (suppl) 111-111, 2014.

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O2H-2-1 Role of VEGFR1 in diabetic wound healing

Shinichiro Okizaki1,2,3, Yoshiya Itoh3, Hirotoki Ookubo3, Ken Kojyou3, Kazuhito Ooba2, Masayoshi Shichiri2, Masataka Majima1
1Dept.Phamacology, Kitasato Univ. Sch. Med, 2Dept. Endocrinology, Kitasato Univ. Sch. Med, 3Dept.Surgery, Kitasato Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 111-111, 2014.

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O2H-2-2 Role of VEGFR1 in liver repair after hepatic ischemia/reperfusion

Hirotoki Ohkubo1,2, Yoshiya Ito2, Tsutomu Minamino1, Ken Kojo1,2, Kanako Hosono1, Masahiko Watanabe2, Masataka Majima1
1Dept. Pharmacol., Kitasato Univ. Sch. Med, 2Dept. Surgery., Kitasato Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 111-111, 2014.

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O2H-2-3 Role of COX-2 and TP signaling in lenhancement of lymph angiogenesis in diaphragm in endotoxins -induced peritonitis

Hiromi Matsuda1, Kanako Hosono2, Chie Kugashige1, Syuu Narumiya3, Masataka Majima2
1Dept. Molecular Pharmacol., Kitasato Uni. Graduate Sch. Medical sciences, 2Dept. of Pharmacol., Kitasato Uni. Sch. Med, 3Kyoto Uni. Graduate Sch. Med. Medical Innovation Center
Journal of Pharmacological Sciences 124 (suppl) 112-112, 2014.

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O2H-2-4 Improvement effect of Na+/Ca2+ inhibitor on efficiency of islet transplantation

Satomi Kita1, Toshiyuki Mera2, Takeshi Itoh2, Shohta Kodama2, Yohichi Yasunami2, Takahiro Iwamoto1
1Dept. Pharmacol., Facul. Med., Fukuoka Univ, 2Dept. Reg. Med. & Transplant., Facul. Med., Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 112-112, 2014.

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O2H-2-5 IL-17A upregulates iNOS expression and attenuates intestinal smooth muscle contractility

Daisuke Mori1, Nobumasa Watanabe2, Osamu Kaminuma2, Takahisa Murata3, Hiroshi Ozaki1, Masatoshi Hori1
1Dept. Vet. Pharmacol, Univ Tokyo, 2Tokyo Metro Inst, 3Dept. Animal Radio. Univ Tokyo
Journal of Pharmacological Sciences 124 (suppl) 112-112, 2014.

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O2H-3-1 Effect of rikkunshito on water avoidance stress-induced inhibition of gastric accommodation in guinea pigs

Junichi Koseki1, Tadayuki Oshima2, Tomohisa Hattori1, Yoshio Kase1, Hiroto Miwa2
1Tsumura Res. Lab., Tsumura & Co, 2Dept. Int. Med., Hyogo Med
Journal of Pharmacological Sciences 124 (suppl) 112-112, 2014.

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O2H-3-2 Rikkunshito, Kampo medicine, ameliorates cachectic symptoms via ghrelin secretion in mice with bleomycin-induced pulmonary fibrosis

Seiichi Iizuka1, Sachiko Mogami1, Chihiro Yamada1, Tomohisa Hattori1, Hironobu Tsubouchi2, Yanagi Shigehisa2, Toshinai Koji2, Nakazato Masamitsu2
1Tsumura Res. Lab, 2Dept. Int. Med., Facul. Med., Miyazaki Univ
Journal of Pharmacological Sciences 124 (suppl) 113-113, 2014.

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O2H-3-3 The cardioprotective effects of San'oshashinto on ischemia/reperfusion injury in ovariectomized rats: involvement of emodin

Mayuko Sakanashi1, Toshihiro Matsuzaki1, Katsuhiko Noguchi1, Junko Nakasone1, Taro Uchida1, Mika Kina1, Makiko Sakanashi2, Haruaki Kubota2, Matao Sakanashi1, Masato Tsutsui1
1Dept. Pharmacol., Grad. Sch. Med., Univ. of the Ryukyus, 2Dept. of Anesth., Grad. Sch. Med., Univ. of the Ryukyus
Journal of Pharmacological Sciences 124 (suppl) 113-113, 2014.

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O2H-3-4 Inhibition of PGE2 production by Sasa Senanensis Rehder alkaline extract in IL-1β-stimulated human gingival and periodontal ligament fibroblasts

Hiroshi Sakagami1,2, Emika Ohkoshi2, Takao Kato1,3, Tetsuo Shimoyama3, Madoka Kitajima4, Hiroshi Oizumi4, Takaaki Oizumi4
1Div. Pharmacol., Meikai Univ. Sch. Dent, 2MPL, Meikai Univ. Sch. Dent, 3Dept. Oral Maxillofacial Surg, Saitama Med. Univ, 4Daiwa Biol. Res. Inst. Co. Ltd
Journal of Pharmacological Sciences 124 (suppl) 113-113, 2014.

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O2H-4-1 The expression of GPR3 protects cerebellar granular neurons from various apoptotic stimuli

Shigeru Tanaka1, Tatsuhiro Miyagi1, Izumi Hide1, Toshihiko Shirafuji1, E.Antonio Chiocca2, Norio Sakai1
1Dept. Pharmacol., Hiroshima Univ. Sch. Biomed. & Health Sci, 2Dept. Neurosurg., Dana-Farber Cancer Inst., USA, Dana-Farber Cancer Institute
Journal of Pharmacological Sciences 124 (suppl) 113-113, 2014.

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O2H-4-2 The involvement of cerebral sodium-glucose transporter type 3 on focal cerebral ischemia

Yui Yamazaki, Shinichi Harada, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gokuin Univ
Journal of Pharmacological Sciences 124 (suppl) 114-114, 2014.

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O2H-4-3 Suppressive effect of orexin-A on the development of post-ischemic glucose intolerance-induced neuronal damage mediated hypothalamus-medulla oblongata-vagus nerve axis

Shinichi Harada, Shogo Tokuyama
Dept. Clinic. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ
Journal of Pharmacological Sciences 124 (suppl) 114-114, 2014.

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O2H-4-4 The evaluation and comparison of new series of SMTPs on the acetic acid-induced embolic cerebral infarct model mice

Keita Shibata1, Terumasa Hashimoto1, Hisayuki Ohata1, Keiji Hasumi2, Kazuo Honda1
1Dept. Pharmacol., Showa Univ., Sch. Pharmacy, 2Dept. Appl. Biol. Sci., Tokyo Univ. of Agricul. and Technol
Journal of Pharmacological Sciences 124 (suppl) 114-114, 2014.

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O2H-5-1 Social isolation impairs sociability and conditional fear memory via central dopaminergic and cholinergic systems, respectively, in mice

Ryo Okada, kinzo matsumoto, daisyu mizuki, Hironori Fujiwara
Inst. Natural Med., Univ. Toyama
Journal of Pharmacological Sciences 124 (suppl) 114-114, 2014.

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O2H-5-2 The role of NOX1/NADPH oxidase in the depressive-like behavior

Masakazu Ibi, Junjie Liu, Chihiro Yabe-Nishimura
Dept. Pharmacol., Kyoto Prefectual Univ. Med
Journal of Pharmacological Sciences 124 (suppl) 115-115, 2014.

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O2H-5-3 Sigma-1 receptor stimulation improves depressive-like behaviors in CaMKIV null mice

Yuzuru Sasaki1, Shigeki Moriguchi1, Hiroyuki Sakagami2, Kohji Fukunaga1
1Dept.Pharmacol., Tohoku Univ., Grad Sch. Pharm. Sci, 2Dept.Anatomy., Kitasato Univ. Sch.Med
Journal of Pharmacological Sciences 124 (suppl) 115-115, 2014.

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O2H-5-4 Sigma-1 receptor stimulation ameliorates transverse aortic constriction-induced depressive-like behaviors

Koga Hirano1, Hideaki Tagashira1, Chen Zhang2, Feng Han2,3, Kohji Fukunaga1
1Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. sci, 2Dept. Pharmacy., Zhejiang Univ. Col. Pharm. Sci, 3Inst. Pharmacol., Zhejiang Univ. Tox and Biochem. Pharm
Journal of Pharmacological Sciences 124 (suppl) 115-115, 2014.

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O2H-5-5 Chronic corticosterone treatment reduces oligodendrocytes in the basolateral amygdala and causes depressive behaviors

Masataka Ishizuka
Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 115-115, 2014.

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O2I-1-1 Clarify the molecular entity of chloride channels in human chondrosarcoma cell line (OUMS-27)

Takashi Kurita1, Yoshiaki Suzuki1, Hisao Yamamura1, Susumu Ohya2, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci, Nagoya City Univ, 2Dept. Pharmacol., Kyoto Pharma. Univ
Journal of Pharmacological Sciences 124 (suppl) 116-116, 2014.

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O2I-1-2 Ca2+ release from mitochondria via peripheral type benzodiazepine receptor (PBR) promoting K+ efflux followed by activating Na+/K+/2Cl- co-transporter

Mitsuru Kawaguchi, Migiwa Okubo, Takashi Shinomiya, Eri Tsukagoshi, Kohei Sawaki
Dept. Pharmacol., Tokyo Dent. Coll
Journal of Pharmacological Sciences 124 (suppl) 116-116, 2014.

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O2I-1-3 Real-time monitoring of Ca2+ responses in rat submandibular glands and salivary secretions in live animals

Akihiro Nezu1, Takao Morita1, Yosuke Tojyo2, Takeharu Nagai3, Akihiko Tanimura1
1Dept. Pharmacol., Sch. Dent., Health Sci. Univ. Hokkaido, 2Dept. Biophys., Sch. Dent., Health Sci. Univ. Hokkaido, 3Inst. Sci., Ind. Res., Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 116-116, 2014.

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O2I-1-4 Development of an in vitro culture method for stepwise differentiation of mouse embryonic stem cells and induced pluripotent stem cells into mature osteoclasts

Keizo Nishikawa, Yoriko Iwamoto, Masaru Ishii
iFReC, Osaka univ
Journal of Pharmacological Sciences 124 (suppl) 116-116, 2014.

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O2I-2-1 Expression of fatty acid binding proteins are involved in cell growth of oral squamous cell carcinoma

Doksa Lee1, 2, Koichiro Wada1, Tomotake Masuda2, Tomonao Aikawa2, Masaya Okura2, Mikihiko Kogo2
1Dept. Pharmacol., Grad. Sch. Dent. Osaka Univ, 2First Dept. Oral Maxillofac. Surg., Grad. Sch. Dent. Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 117-117, 2014.

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O2I-2-2 Bidirectional communication between sensory neuronal cells and osteoblasts in an in vitro co-culture system

Daisuke Kodama, Akifumi Togari
Dept. Pharmacol., Aichi-Gakuin Univ. Sch. Dent
Journal of Pharmacological Sciences 124 (suppl) 117-117, 2014.

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O2I-2-3 Keratin 13 gene silencing in oral squamous cell carcinoma cells through epigenetic chromatin modifications

Mitsutoki Hatta1, Kaori Naganuma1,2, Tsuyako Ohkubo1, Tetsuro Ikebe2, Jun Yamazaki1
1Dept. PhysioL Sci. Mol. Biol, 2Dept. Oral. Maxillofac. Surg
Journal of Pharmacological Sciences 124 (suppl) 117-117, 2014.

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O2I-2-4 Role of tissue-type plasminogen activator in bone repair

Naoyuki Kawao1, Yukinori Tamura1, Katsumi Okumoto2, Masato Yano1, Kiyotaka Okada1, Osamu Matsuo1, Hiroshi Kaji1
1Dept. Physiol. & Regen. Med., Kinki Univ. Fac. Med, 2Life Sci. Res. Inst., Kinki Univ
Journal of Pharmacological Sciences 124 (suppl) 117-117, 2014.

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O2I-3-1 Mechanisms of cisplatin-induced muscle atrophy and muscle fatigue

Ryoto Sugiyama1, Hiroyasu Sakai1, Atsunobu Sagara1, Akiko Hirosaki1, Ara Jo1, Kazuhide Takase1, Ken Sato1, Tomomi Yamada1, Yoshihiko Chiba2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm, 2Dept. Biol., Hoshi Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 118-118, 2014.

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O2I-3-2 Irinotecan-induced muscle atrophy and muscle fatigue

Akiko Hirosaki1, Hiroyasu Sakai1, Ryoto Sugiyama1, Atsunobu Sagara1, Ara Jo1, Kazuhide Takase1, Ken Sato1, Tomomi Yamada1, Yoshihiko Chiba2, Minoru Narita1
1Dept. Pharmacol., Hoshi Univ. Sch. Pharm, 2Dept. Biol., Hoshi Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 118-118, 2014.

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O2I-3-3 5-Aza-2-deoxycytidine enhances the sensitivity of 5-fluorouracil in KB3-1 human carcinoma cells

Yukihiko Nishizawa1, Ryuji Ikeda1, 2, Yusuke Tajitsu1, 2, Kouichi Kawahara3, Masatatsu Yamamoto3, Yoshinari Shinsato3, Kentaro Minami1, Tatsuhiko Furukawa3, Yasuo Takeda1,2
1Dept. Clin. Pharm. and Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ, 2Dept. Clin. Pharm., Kagoshima Univ. Hosp, 3Dept. Mol. Oncology, Grad. Sch. Med. Dent. Sci., Kagoshima Univ
Journal of Pharmacological Sciences 124 (suppl) 118-118, 2014.

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O2I-3-4 AZT inhibits autophagic process in H9c2 cells

Qichao Song, Teruyuki Yanagisawa, Takeya Sato
Dept. Molpharm., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 118-118, 2014.

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O2I-4-1 Molecular mechanism of 2-APB-induced Ca2+ influx in external acidification in PC12

Kenji Takahashi, Minae Yokota, Toshio Ohta
Dept. Vet. Pharmacol., Fac. Agri., Tottori Univ
Journal of Pharmacological Sciences 124 (suppl) 119-119, 2014.

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O2I-4-2 Involvement of AMPK in bupivacaine-induced increase in WDR35 expression in Neuro2a cells

Lei Huang, Fumio Kondo, Guo-Gang Feng, Akiko Fujisawa, Naohisa Ishikawa, Shoshiro Okada
Dept. Pharmacol., Aichi Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 119-119, 2014.

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O2I-4-3 Long-term sensory deprivation from postnatal period increases in the number of GABAergic interneurons in the mouse prefrontal cortex

Hiroshi Ueno1, Hideo Takahashi1, Atsuko Niwa1, Shinichi Hamasaki1, Motoi Okamoto2
1Dept. Pharmacol., Kinki Univ. Sch. Med, 2Grad Sch of Health Sci, Okayama Univ
Journal of Pharmacological Sciences 124 (suppl) 119-119, 2014.

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O2I-4-4 L-type voltage-dependent calcium channel is involved in secretory phospholipase A2s-induced neuronal apoptosis

Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma, Kazunori Murakami, Asako Oya, Seiya Hisamura, Yuma Kobayashi
Dept. Physiol., Himeji Dokkyo Univ., Fac. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 119-119, 2014.

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O2I-4-5 Imaging of neuronal activity in zebrafish during visual perception using G-CaMP7a, an improved genetically encoded green fluorescent calcium indicator

Masamichi Ohkura1, Akira Muto2,3, Gembu Abe2, Koichi Kawakami2,3, Junichi Nakai1
1Saitama Univ. Brain Sci. Inst, 2Div. Mol. Dev. Biol., Natl. Inst. Genet, 3Dept. Genet., SOKENDAI
Journal of Pharmacological Sciences 124 (suppl) 120-120, 2014.

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O2I-5-1 Binding characterization and clinical application of novel PET tracer 18F-THK5117 for in vivo imaging of tau pathology in Alzheimer's disease

Ryuichi Harada1, Nobuyuki Okamura1, Shozo Furumoto2, Katsutoshi Furukawa3, Aiko Ishiki3, Naoki Tomita3, Tetsuro Tago2, Takeo Yoshikawa1, Ren Iwata2, Manabu Tashiro2, Hiroyuki Arai3, Yukitsuka Kudo4, Kazuhiko Yanai1
1Dept. Pharmacol., Tohoku Univ. Sch. Med, 2Tohoku Univ. CYRIC, 3Dept. Geriatrics., IDAC, Tohoku Univ. Sch. Med, 4Tohoku Univ. Hospital, CREITO
Journal of Pharmacological Sciences 124 (suppl) 120-120, 2014.

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O2I-5-2 Possible involvement of the ubiquitin ligases Dorfin and RNF19B in Aβ generation mediated by protein trafficking

Masayuki Kaneko1, Masashi Yamamori2, Naoki Noguchi1, Ryo Saito2, Isao Hozumi1, Yasunobu Okuma2, Yasuyuki Nomura3
1Lab. Med. Ther. & Mol. Ther., Gifu Pharmceut. Univ, 2Dept. Pharmacol., Fac. Pharmaceut. Sci., Chiba Inst. Sci, 3Dept. Pharmacol., Kurume Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 120-120, 2014.

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O2I-5-3 Effects of oxidative stress on the solubility of an Alzheimer's disease-related ubiquitin ligase HRD1

Ryo Saito1, Masayuki Kaneko1,2, Koichi Kawada1, Yasuyuki Nomura3, Yasunobu Okuma1
1Dept. Pharmacol., Chiba Inst. Sci, 2Lab. Med. Therap. and Mol. Therap., Gifu Pharm. Univ, 3Dept. Pharmacol., Kurume Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 120-120, 2014.

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O2I-5-4 An anti-Alzheimer's disease mutation makes amyloid precursor protein unable to mediate transforming growth factor β2-induced neurotoxicity

Yuichi Hashimoto, Masaaki Matsuoka
Dept. Pharmacol., Tokyo Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 121-121, 2014.

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O2I-5-5 Role of Na+ /Ca2+ exchanger in Alzheimer's disease

Shigeki Moriguchi1, Satomi Kita2, Takahiro Iwamoto2, Kohji Fukunaga1
1Dept. Pharmacol., Tohoku Univ., Grad. Sch. Pharmaceut. Sci, 2Dept. Pharmacol., Fukuoka Univ., Med. Sch
Journal of Pharmacological Sciences 124 (suppl) 121-121, 2014.

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O3F-1-1 The glutamate transporter transmembrane domain is a filopodia tip localizer / stabilizer

Mariko Hayashi, Masato Yasui
Dept.Pharmacol., Keio Univ., Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 121-121, 2014.

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O3F-1-2 Role of Elfn1 in hippocampal inhibitory neural circuits containing somatostatin-positive neurons

Naoko Tomioka1, Hiroyuki Miyamoto1, Minoru Hatayama1,2, Naoko Morimura1, Yoshifumi Matsumoto1, Toshimitsu Suzuki1, Yoshimi Iwayama1, Kazuyuki Yamada1, Takeo Yoshikawa1, Kazuhiro Yamakawa1, Jun Aruga1,2
1RIKEN BSI, 2Dept. Pharmacol., Nagasaki Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 121-121, 2014.

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O3F-1-3 Feeding behavior in mice influences glutathione synthesis in the hippocampus

Koji Aoyama, Wattanaporn Sumida, Hiroyuki Oshikane, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 122-122, 2014.

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O3F-1-4 Functional expression of Ca2+- activated Cl- (TMEM16B) channel in rat pineal glands

Kaori Nishimura, Hisao Yamamura, Yuji Imaizumi
Dept. Mol. & Cell. Pharmacol., Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 122-122, 2014.

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O3F-1-5 17β-estradiol promotes survival by inhibiting hippocampal GluR2 internalization following pilocarpine-induced epilepsy in mice

Kenjiro Seki, Nobuaki Ohtake, Yuki Iitsuka
Dept. Pharmacol., School of Pharmaceutical Science, Ohu University
Journal of Pharmacological Sciences 124 (suppl) 122-122, 2014.

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O3F-2-1 Imaging of activity-dependent Ca2+ dynamics in the endoplasmic reticulum of Purkinje cells

Yohei Okubo, Junji Suzuki, Kazunori Kanemaru, Masamitsu Iino
Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 122-122, 2014.

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O3F-2-2 Obesity increases excitability of ventral tegmental area dopamine neurons by attenuating D2 autoreceptor-mediated inhibition

Susumu Koyama1, Masayoshi Mori1, Syohei Kanamaru1, Hiroki Terai1, Takuya Sazawa1, Ayano Miyazaki1, Shinichi Hirose2,3
1Dept. Psychosomatic Med., Pharmaceut. Sci., Fukuoka Univ, 2Dept. Pediatrics, Sch. Med., Fukuoka Univ, 3Central Res. Inst. Pathomechanims of Epilepsy, Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 123-123, 2014.

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O3F-2-3 Analysis of prostanoids in the microdialysates from hypothalamic PVN of freely moving rats

Masahiko Tachi1,3, Fumio Kondo1, Minoru Fukayama2, Kazuhiro Yoshikawa2, Katsuhiko Matsuura3, Shoshiro Okada1
1Dept. Pharmacol., Aichi Med. Univ. Grad. Sch. Med, 2Dept. Cent. Res. Lab., Aichi Med. Univ. Sch. Med, 3Dept. Pharm., Aichi Med. Univ. Hosp
Journal of Pharmacological Sciences 124 (suppl) 123-123, 2014.

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O3F-2-4 A novel pathway fot the production of hydrogen sulfide from D-cysteine in mammalian cells

Norihiro Shibuya1, Shin Koike2, Mari Yuasa-Ishigami1, Makiko Tanaka1, Yuka Kimura1, Yuki Ogasawara2, Kiyoshi Fukui3, Noriyuki Nagahara4, Hideo Kimura1
1Dept. Mol. Pharm., Natl. Inst. Neurosci., NCNP, 2Dept. Hygienic Chemistry, Meiji Pharm. Univ, 3Inst. Enzyme Res., Univ. of Tokushima, 4Isotope Res. Center, Nippon Med. Sch
Journal of Pharmacological Sciences 124 (suppl) 123-123, 2014.

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O3F-2-5 Increased sensitivity to methamphetamine in synaptic vesicle protein 2A (SV2A)-mutant rats

Kentaro Tokudome1, Saki Shimizu1, Takahiro Okumura1, Naofumi Kunisawa1, Sana Kihara1, Sanae Nakashima1, Aduki Hashimoto1, Yuki Hiraoka1, Kazuki Fukuda1, Tomoji Mashimo2, Tadao Serikawa1,2, Yukihiro Ohno1
1Lab. Pharmacol., Osaka Univ. Pharm. Sci, 2Inst. Lab. Animals, Kyoto Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 123-123, 2014.

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O3F-3-1 Microglia trigger astrocytes-mediated neuroprotection via purinergic gliotransmission

Youichi Shinozaki1, Schuichi Koizumi1,2
1Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineer., Univ. Yamanashi, 2JST, CREST
Journal of Pharmacological Sciences 124 (suppl) 124-124, 2014.

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O3F-3-2 Induction of proinflammatory cytokines and change in neurotrophic factors expression by amphotericin B in cultured microglia

Katsura Takano, Akiko Motoyoshi-Yamashiro, Kenji Kawabe, Mitsuaki Moriyama, Yoichi Nakamura
Lab. Integrative Physiol. Vet. Sci., Osaka Pref. Univ
Journal of Pharmacological Sciences 124 (suppl) 124-124, 2014.

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O3F-3-3 A role of the osteoblastic master regulator, runt-related transcription factor-2, in microglial cells

Ryota Nakazato, Takeshi Takarada, Yukio Yoneda
Laboratory of Molecular Pharmacology, Kanazawa University Graduate School o f Natural Science and Technology
Journal of Pharmacological Sciences 124 (suppl) 124-124, 2014.

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O3F-3-4 IRF5 directly regulates P2X4R+ reactive state of microglia driving neuropathic pain

Takahiro Masuda1, Shosuke Iwamoto1, Ryohei Yoshinaga1, Hidetoshi Tozaki-Saitoh1, Akira Nishiyama2, Tak W.Mak3, Tadatsugu Taniguchi4, Tomohiko Tamura2, Makoto Tsuda1, Kazuhide Inoue1
1Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci., Kyushu Univ, 2Dept. Immunol., Grad. Sch. Med., Yokohama City Univ, 3Princess Margaret Cancer Centre, Univ. Health Network, 4Dept. Mol. Immunol., Inst. Indus. Sci., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 124-124, 2014.

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O3F-3-5 Regulation of synaptic strength are controlled by circadian rhythm of cathepsin S expression in the microglia

Yoshinori Hayashi1, Saoru Koyanagi2, Naoki Kusunose2, Ryo Okada1, Zhou Wu1, Hidetoshi Saitoh3, Shinichi Kohsaka4, Kazuhide Inoue3, Shigehiro Ohodo2, Hiroshi Nakanishi1
1Dept. Aging Sci. and Pharmacol. Facul. Dent. Sci. Kyushu Univ, 2Dept. Pharmace. Grad. Sch. Pharmace. Sci. Kyushu Univ, 3Dept. Mol. Sys. Pharmacol. Grad. Sch. Pharmace. Sci. Kyushu Univ, 4Dept. Neurochem. National Instit. Neurosci
Journal of Pharmacological Sciences 124 (suppl) 125-125, 2014.

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O3F-4-1 Molecular mechanism of urate-lowering effect of calcium channel blockers

Go Tsuchiya1, 2, Promsuk Jutabha1, Kazuhisa Okamoto1, Kenji Hnada1, Tokuro Abe1, Hirotsugu Fukuda2, Naohiko Anzai1
1Dept. Pharmacol., Dokkyo Medical Univ. Sch. Med, 2Dept. Cardiovascular Surgery., Dokkyo Medical Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 125-125, 2014.

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O3F-4-2 Development of fluorometric analysis for characterization of urate transporter 1

Makiko Nakamura1, Takumi Adachi1, Makoto Hosoyamada2, Kimiyoshi Ichida1
1Dept. Pathophysiol., Tokyo Univ. Pharm. Life Sci, 2Dept. Human Pathol. Physiol., Teikyo Univ
Journal of Pharmacological Sciences 124 (suppl) 125-125, 2014.

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O3F-4-3 Multiphoton imaging of septic kidney

Daisuke Nakano, Akira Nishiyama
Dept. Pharmacol., Kagawa Univ
Journal of Pharmacological Sciences 124 (suppl) 125-125, 2014.

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O3F-4-4 Advanced glycation end product-cholesterol-aggregated protein increased the expression of pro-inflammatory cytokines in human mesangial cells

Tadashi Nagamatsu1,2, Tomohiro Mizuno1, Kayoko Takagi1, Yumika Okumura1, Yasusi Hirasawa2
1Lab. Analytical Pharamacol., Meijo Univ. Sch. Pharma, 2Jap. Bio.Research. INC
Journal of Pharmacological Sciences 124 (suppl) 126-126, 2014.

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O3F-4-5 The role of N-type calcium channel in renal podocytes

Ya Liu, Daisuke Nakano, Yuki Shibayama, Akira Nishiyama
Dept. Pharmacol., Kagawa Univ
Journal of Pharmacological Sciences 124 (suppl) 126-126, 2014.

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O3F-4-6 Transcellular secretory transport of diuretic drugs in renal proximal tubule

Promsuk Jutabha1, Michael Wempe2, Hitoshi Endou3, Naohiko Anzai1
1Dept. Pharmacol. Toxicol., Dokkyo Medical Univ. Sch. Med, 2Dept. Pharm. Sci., Sch. of Pharm., Univ. of Colorado, 3J-Pharma Co. Ltd
Journal of Pharmacological Sciences 124 (suppl) 126-126, 2014.

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O3G-1-1 The role of dopaminergic functions in the lateral hypothalamus in feeding behavior of mice

Hiroko Ikeda1, Chrismawan Ardianto1, Naomi Yonemochi1, Lizhe Yang1, Megumi Ikegami1, Fumiko Takenoya2, Seiji Shioda3, Junzo Kamei1
1Dept. Pathophysiol. Ther, Hoshi Univ. Sch. Pharm. Pharmaceut. Sci, 2Dept. Exerc. Sports Physiol., Hoshi Univ. Sch. Pharm. Pharmaceut Sci, 3Dept. Anat., Showa Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 126-126, 2014.

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O3G-1-2 Histamine H3 receptors regulated locomotor activity via histamine H2 receptors

Attayeb Mohsen, Takeo Yoshikawa, Fumito Naganuma, Tadaho Nakamura, Tomomitsu Iida, Yamato Miura, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ., Grad. sch. Med
Journal of Pharmacological Sciences 124 (suppl) 127-127, 2014.

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O3G-1-3 Early and late Arc expression differentially contribute to fear memory retention

Daisuke Nakayama, Hirokazu Iwata, Norio Matsuki, Hiroshi Nomura
Lab. Chem. Pharmacol. Grad. Sch. Pharmaceut. Sci. Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 127-127, 2014.

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O3G-1-4 Manipulation of reward-based decision-making in rodent by using a new technology, designer receptors exclusively activated by designer drug (DREADD) system

Hiroyuki Mizoguchi1, Kazuya Fukumoto1, Ayumu Inutsuka2, Akihiro Yamanaka2, Kiyofumi Yamada3
1Fut. Environ. Sim. Center, Res. Inst. Environ. Med., Nagoya Univ, 2Dep. Neurosci., Res. Inst. Environ. Med., Nagoya Univ, 3Dep. Neuropsychopharmacol. and Hosp. Pharm., Nagoya Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 127-127, 2014.

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O3G-1-5 Chemokine CCL2 plays an important role in psychological dependence on methamphetamine

Naoki Wakida, Fumihiro Saika, Yuka Kobayashi, Norikazu Kiguchi, Shiro Kishioka
Dept. Pharmacol., Wakayama Med Univ
Journal of Pharmacological Sciences 124 (suppl) 127-127, 2014.

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O3G-2-1 Peroxynitrite negatively regulates mitochondrial degradation via denitrosylation and tyrosine nitration of parkin

Kentaro Ozawa1, Akira Komatsubara1,2, Hiroto Kawafune1,2, jing zhao1, Yoji Kyotani1, Satoyasu Ito1, Kosuke Nagayama1, Yuichi Tsuji1, Masanori Yoshizumi1
1Dept. Pharmacol., Nara Med. Univ. Sch, 2Dept. Pharm., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 128-128, 2014.

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O3G-2-2 High-mobility group box-1 is involved in NMDA-induced retinal injury the in rat retina

Kenji Sakamoto, Aya Mizuta, Yuki Kurauchi, Asami Mori, Tsutomu Nakahara, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 128-128, 2014.

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O3G-2-3 Identification of genes associated with autism through cell-based screening

Daisuke Takei1, Shigeyuki Namiki1, Isamu Taikou1, Daisuke Asanuma1, Masayuki Isa1, Kohtaroh Sugao1, Miyuki Takeshima2, Yoshimi Iwayama3, Kazuo Yamada3, Takeo Yoshikawa3, Hiroshi Takeshima2, Kenzo Hirose1
1Dept. Neurobiol., Grad. Sch. Med., The Univ. Tokyo, 2Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ, 3Lab for Molecular Psychiatry, RIKEN BSI
Journal of Pharmacological Sciences 124 (suppl) 128-128, 2014.

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O3G-2-4 Hippocampal neurogenesis disorder and mood disorder-like behavior in clock mutant mice

Jun Takoda1, Hiromu Fukuzawa1, Tokiko Suzuki1, Shigenobu Shibata2, Takahiro Moriya1
1Dept. Cell. Signal., Grad. Sch. Pharm. Sci., Tohoku Univ, 2Lab. Physiol. & Pharm., Sch. Adv. Sci. & Eng., Waseda Univ
Journal of Pharmacological Sciences 124 (suppl) 128-128, 2014.

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O3G-2-5 Antidepressant-like effects of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action

Daishu Mizuki1, Kinzo Matsumoto1, Ken Tanaka2, Hironori Fujiwara1, Xoan.T Le1, Yoshihiro Higuchi3, Tsutomu Ishikawa4
1Inst. Natural Med., Univ. Toyama, 2Inst. Natural Med., Univ. Toyama, 3Shiratori pharm. Co. Ltd, 4Grad. Sch. Pharm. Sci., Univ. Chiba
Journal of Pharmacological Sciences 124 (suppl) 129-129, 2014.

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O3G-3-1 Bovine milk-derived α-lactalbumin inhibits colon inflammation and carcinogenesis in azoxymethane and dextran sodium sulfate-treated mice

Makoto Yamaguchi1, Shoko Takai1, Akira Hosono2, Taiichiro Seki2
1Food Sci. Res. Labs, R&D Div., Meiji Co., Ltd, 2Coll. of Bioresource Sci., Nihon Univ
Journal of Pharmacological Sciences 124 (suppl) 129-129, 2014.

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O3G-3-2 (Pro)renin receptor is crucial for Wnt/ β-catenin-dependent genesis of pancreatic ductal adenocarcinoma

Nishiyama Akira, Hiroyuki Kobori, Hirofumi Hitomi, Daisuke Nakano, Yuki Shibayama
Kagawa University Medical School
Journal of Pharmacological Sciences 124 (suppl) 129-129, 2014.

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O3G-3-3 Heat shock protein 72 is a key molecule in oxaliplatin resistance in human gastric cancer cell

Katsuyuki Takahashi1,3, Masako Tanaka1, Masayuki Shiota1, Yasukatsu Izumi1, Katsuyuki Miura2, Hiroshi Iwao1
1Dept. Parmacol., Osaka City Univ. Grad. Sch. Med, 2Appl. Pharmacol. Ther., Osaka City Univ. Grad. Sch. Med, 3Dept. Pharm., Osaka City Univ. Hosp
Journal of Pharmacological Sciences 124 (suppl) 129-129, 2014.

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O3G-3-4 Evaluation of amino acid transporter LAT1 as a molecular target of anti-tumor therapy by means of the combination of comprehensive proteomics and transport assay

Shushi Nagamori, Pattama Wiriyasermkul, Noriyoshi Isozumi, Pornparn Kongpracha, Ryuichi Ohgaki, Yoshikatsu Kanai
Bio-Sys. Pharmacol., Dept. Pharmacol., Osaka Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 130-130, 2014.

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O3G-3-5 Perspective of Aurora A kinase as a therapeutic target for cancer

Hidemasa Goto1,2, Nobumoto Watanabe3, Akihito Inoko1, Masaki Inagaki1,2
1Div. Biochem., Aichi Cancer Ctr. Res. Inst, 2Dept. Cell. Oncol., Nagoya Univ. Grad. Sch. Med, 3RIKEN, Bioprobe U
Journal of Pharmacological Sciences 124 (suppl) 130-130, 2014.

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O3G-4-1 The recent trend of Alternative Animal Experiments for food or chemica

Masaharu Akita1, yuji Yoshiyama2
1Dept. Nutri., Kamakura Univ, 2Div.Community Pham., Kitasato Univ. Sch.Pharm
Journal of Pharmacological Sciences 124 (suppl) 130-130, 2014.

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O3G-4-2 Mifepristone induces non-obese non-alcoholic fatty liver disease

Takeshi Hashimoto, Junsuke Igarashi, Tetsuo Yamashita, Hiroaki Kosaka
Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University
Journal of Pharmacological Sciences 124 (suppl) 130-130, 2014.

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O3G-4-3 Systems pharmacology of developmental neurotoxicity of drugs using zebrafish

Yuhei Nishimura1,2,3,4,5, Soichiro Murakami1, Yoshifumi Ashikawa1, Syota Sasagawa1, Noriko Umemoto1,3, Miko Kawabata1, Beibei Zhang1, Yasuhito Shimada1,2,3,4,5, Toshio Tanaka1,2,3,4,5
1Dept, of Molecular and Cellular Pharmaco, Pharmacogeno and Pharmacoinfo, Mie Univ. Grad. Sch. of Med, 2Mie Univ. Medical Zebrafish Res. Cent, 3Dept. of Systems Pharmaco., Mie Univ. Grad. Sch. of Med, 4Dept of Omics Med., Mie Uni. Indust. Tech. Innova. Inst, 5Dept of Bioinfo. Mie Univ. Life Sci. Res. Cent
Journal of Pharmacological Sciences 124 (suppl) 131-131, 2014.

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O3G-4-4 Identification of cytotoxic compounds in cigarette smoke gas phase and molecular mechanisms for their cytotoxicity

Tsunehito Higashi, Yosuke Mai, Takahiro Horinouchi, Koji Terada, Akimasa Hoshi, Mika Horiguchi, Prabha Nepal, Takuya Harada, Chizuru Hatate, Soichi Miwa
Dept. Cellular Pharmacol, Grad. Sch. Med., Hokkaido Univ
Journal of Pharmacological Sciences 124 (suppl) 131-131, 2014.

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O3G-4-5 Drug-induced cardiomyopathy revealed from mitochondrial dynamics

Mikio Muraoka, teruyuki yanagisawa, Takeya Satou
Dept.Molpharm., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 131-131, 2014.

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O3G-4-6 Animal model for postoperative nausea and vomiting using pica behavior in rats

Kouichi Yamamoto, Toru Sugimoto, Takuya Sakagami
Lab. Pharmacol., Dept. Med. Sci. Tech., Div. Health Sci, Grad. Sch. Med. Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 131-131, 2014.

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O3H-1-1 Roles of Ca2+ release-activated Ca2+ channels on cell cycle progression in bovine brain capillary endothelial cells

Hiroaki Kito1, Hisao Yamamura1, Yoshiaki Suzuki1, Susumu Ohya1,2, Kiyofumi Asai3, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmceut. Sci, Nagoya City Univ, 2Dept. Pharmacal., Kyoto Pharm. Univ, 3Dept. Mol. Neurobiol., Grad. Sch. Med. Sci., Nagoya City Univ
Journal of Pharmacological Sciences 124 (suppl) 132-132, 2014.

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O3H-1-2 Functional impairment of NO is earlier than that of EDHF in 5/6 nephrectomized rat

Shuhei Kobuchi, Kazuhide Ayajiki
Dept. Pharm., School of Pharm., Hyogo Univ. Health Sci
Journal of Pharmacological Sciences 124 (suppl) 132-132, 2014.

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O3H-1-3 Antiplatelet effect of tetrahydrobiopterin in mouse whole blood aggregation and its NO-independent mechanism

Yui Suganuma, Taiki Kano, Kazuhisa Ikemoto, Chiho Ichinose, Takahide Nomura, Kazunao Kondo
Dept. Pharmacol., Sch. Med., Fujita Health Univ
Journal of Pharmacological Sciences 124 (suppl) 132-132, 2014.

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O3H-1-4 The characteristics of TMEM 16A splicing variants functionally expressed in mice portal vein

Junya Ohshiro1, Takanori Saeki1, Hisao Yamamura1, Yoshiaki Suzuki1, Susumu Ohya1,2, Yuji Imaizumi1
1Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmceut. Sci., Nagoya City Univ, 2Dept. Pharmacol., Kyoto Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 132-132, 2014.

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O3H-1-5 Expression analyses of TMEM16A in portal veins of portal hypertensive model mice

Rubii Kondo, Junya Ohshiro, Yoshiaki Suzuki, Hisao Yamamura, Yuji Imaizumi
Dept. Mol. Cell. Phamacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ
Journal of Pharmacological Sciences 124 (suppl) 133-133, 2014.

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O3H-1-6 Influence of ALDH2 genotype on vascular endothelial function after a long-term treatment with glyceryl trinitrate

Tatsuya Yoshihara1, Fumie Shiraishi1, Hisatomi Arima2, Fumi Takahashi-Yanaga3, Hideyuki Ikematsu4, Toshiyuki Sasaguri1
1Dept. Cli Pharmacol., Kyushu Univ, 2Geroge Institute, 3Dept. Med. Edu., Kyushu Univ, 4Center. Med. Innov., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 133-133, 2014.

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O3H-2-1 Ca2+ release properties of arrhythmogenic ryanodine receptor type 2 mutants

Nagomi Kurebayashi1, Takashi Murayama1, Junji Suzuki2, Kazunori Kanemaru2, Masamitsu Iino2, Takashi Sakurai1
1Dept. Pharmacol., Juntendo Univ. Sch. Med, 2Dept Pharmacol. Grad. Sch. Med., The Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 133-133, 2014.

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O3H-2-2 Inhibition of sarcolemmal accumulation of TRPV2 prevents progression of dilated cardiomyopathy in animal models

Yuko Iwata, Hitomi Otake, Shinya Kamauchi, Shigeo Wakabayashi
Dept. Mol. Physiol, N.C.V.C
Journal of Pharmacological Sciences 124 (suppl) 133-133, 2014.

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O3H-2-3 Cardioprotective effect of nicorandil, a mitochondrial potassium channel opener, via modification of mitochondrial permeability transition pore in myofibrilar myopathy

Toshinori Aoyagi, Yu Yamatoya, Kaori Natsusaka, Yu Tezuka, Atsushi Sanbe
Dept. Pharmacothera., Iwate Med. Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 134-134, 2014.

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O3H-2-4 Phosphorylation of L-type Ca2+ channel β2a subunit induces cardiomyocyte hypertrophy

Nao Hayamizu, Shohei Kumagai, Sachi Matsunami, Hiroyuki Nakayama, Yasushi Fujio
Lab. Clinical Science and Biomedicine, Osaka Univ. Sch. Pharmaceut
Journal of Pharmacological Sciences 124 (suppl) 134-134, 2014.

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O3H-2-5 A Proarrhythmic Effect of Na Channel Blockers Involved in Subcellular Na Channel Remodeling in Ischemic Border Zone: In Silico Study

Kunichika Tsumoto1, Takashi Ashihara2, Ryo Haraguchi3, Kazuo Nakazawa4, Yoshihisa Kurachi1
1Grad. Sch. Med, Osaka Univ, 2Dept. Cardiovasc Med, Heart Rhythm Center, Shiga Univ. Med. Sci, 3Dept. Med. Infarmatics, Nat. Cerebral. Cardiovasc Center, 4Labo. Biomed. Info. Man, Nat. Cerebral. Cardiovasc. Center. Res. Inst
Journal of Pharmacological Sciences 124 (suppl) 134-134, 2014.

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O3H-3-1 Stimulation with β-adrenoceptor or 5-hydroxytryptamine 4 receptor enhances neural differentiation of mouse induced pluripotent stem cells through activation of cyclic AMP/ protein kinase A signaling pathway

Toshiaki Ishizuka, Ayako Ozawa, Munemitu Arata, Yasuhiro Watanabe
Dept. Pharmacol., Natl. Def. Med. Col
Journal of Pharmacological Sciences 124 (suppl) 134-134, 2014.

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O3H-3-2 Increase in osteogenic differentiation potential of mesenchymal stem cells from patients with ectopic ossification in spinal ligament

Yoshifumi Harada1,2, Ken-Ichi Furukawa1, Toru Asari2, Shunfu Chin1,2, Atushi Ono2, Takuya Numasawa2, Hiroki Mizukami3, Manabu Murakami1, Soroku Yagihashi3, Shigeru Motomura1, Yasuyuki Ishibashi2
1Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med, 2Dept. Orthop. Surg. Hirosaki Univ. Grad. Sch. Med, 3Dept. Pathol. Mol. Med., Hirosaki Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 135-135, 2014.

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O3H-3-3 Activation of keratinocyte-derived latent TGF-β1 induced fibroblast differentiation in a wound-healing model of rat skin

Shozaburo Hata1, Taiki Suyama1, Mitsutoki Hatta2, Hiroyuki Ishikawa1, Jun Yamazaki2
1Dept. Oral Growth Develop., Fukuoka Dent. Coll, 2Dept. Physiol. Sci. & Mol. Biol., Fukuoka Dent. Coll
Journal of Pharmacological Sciences 124 (suppl) 135-135, 2014.

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O3H-3-4 Voluntary exercise enhances neurogenesis in hypothalamus after stroke

Atsuko Niwa1, Yasumitsu Akahoshi2, Yoshitaka Horiuchi2, Shin-ichi Hamasaki1, Masahiro Nishibori3, Hideo Takahashi1
1Dept. Pharmacol., Kinki Univ. Facul. Med, 2Life Sci. Res. Inst., Kinki Univ, 3Dept, Pharmacol., Okayama Univ., Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 135-135, 2014.

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O3H-4-1 Analysis of a mew PAI-1 deficient patient

Takayuki Iwaki1, Kotomi Nagahashi1,2, Tetsumei Urano3, Naohiro Kanayama2, Katsuhiro Takano4, Yukio Ozaki4, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med, 2Dept. OB/GYN., Hamamatsu Univ. Sch Med, 3Dept. Med. Physiol., Hamamatsu Univ. Sch. Med, 4Dept. Clinical and Laboratory Medicine, Univ. Yamanashi
Journal of Pharmacological Sciences 124 (suppl) 135-135, 2014.

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O3H-4-2 Involvement of microRNAs and an RNA-binding protein in impaired stabilization of FOS mRNA in myelodysplastic syndromes (MDS)

Yayoi Shikama1, Meiwan Cao1, Michiko Anzai1, Xiaomin Feng1, Hideyoshi Noji2, Hideo Kimura3, Kazuei Ogawa2, Kazuhiko Ikeda2, Yasuchika Takeishi2, Junko Kimura1
1Dept. Pgarmacol., Fukushima Med. Univ, 2Dept. Cardiol. Hematol., Fukushima, Med. Univ, 3Kita-Fukushima Med. Centr
Journal of Pharmacological Sciences 124 (suppl) 136-136, 2014.

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O3H-4-3 Thromboxane A2 plays a critical role in reduction of the anti-platelet effect of prostaglandin I2 receptor agonist beraprost after repeated administration

Hitoshi Kashiwagi1,2, Koh-ichi Yuhki1,2, Fumiaki Kojima1,2, Shima Kumei1,2, Yoshiki Sakai3, Shuh Narumiya2,4, Fumitaka Ushikubi1,2
1Dept. Pharmacol., Asahikawa Med. Univ, 2JST, CREST, 3Ono Pharmaceutical Co., Ltd., Research Headquarters, 4Dept. Pharmacol., Kyoto Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 136-136, 2014.

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O3H-4-4 Finding of selective tissue factor/factor VIIa complex inhibitor as a novel anticoagulant with lower bleeding risk

Nagakura Tadashi, Kimiyo Tabata, Kazunobu Kira, Shinsuke Hirota, Clark Richard, Fumiyoshi Matsuura, Hironobu Hisyohi
Eisai.Co.Ltd., Tsukuba Research Laboratory
Journal of Pharmacological Sciences 124 (suppl) 136-136, 2014.

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O3H-4-5 Chronic psychological stress-induced platelet hyperaggregability is caused by enhancement of dense granule secretion in mice

Fumikazu Matsuhisa, Eiki Satoh
United Grad. Sch. Vet. Sci., Gifu Univ, Res. Cent. Animal Hyg. Food Saf., Obihiro Univ. Agric. Vet. Med
Journal of Pharmacological Sciences 124 (suppl) 136-136, 2014.

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O3I-1-1 Clioquinol induced the expression of VGF, the precursor of neuropeptides, by inducing c-Fos expression

Masato Katsuyama1, Chihiro Yabe-Nishimura2
1Radioisotope Ctr., Kyoto Pref. Univ. Med, 2Dept. Pharmacol., Kyoto Pref. Univ. Med
Journal of Pharmacological Sciences 124 (suppl) 137-137, 2014.

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O3I-1-2 Functional analysis of type 1 ryanodine receptor carrying N-terminal malignant hyperthermia associated mutations

Toshiko Yamazawa1, Takashi Murayama2, Hideto Oyamada3, Junji Suzuki4, Kazunori Kanemaru4, Nagomi Kurebayashi2, Katsuji Oguchi3, Takashi Sakurai2, Shigeru Takemori1, Masamitsu Iino4
1Dept Mol. Physiol., Jikei Univ. Sch. Med, 2Dept. Pharmacol., Juntendo Univ. Sch. Med, 3Dept. Pharmacol., Sch. Med., Shown Univ, 4Dept. Pharmacol., Grad. Sch. Med., The Univ.Tokyo
Journal of Pharmacological Sciences 124 (suppl) 137-137, 2014.

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O3I-1-3 Modulatory effects of a novel BKα splice variant on BK channel functions

Yoshiaki Suzuki1, Susumu Ohya2, Hisao Yamamura1, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ, 2Dept. Pharmacol., Kyoto Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 137-137, 2014.

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O3I-1-4 Disease-associated mutations at the N-terminal region on the RyR1 divergently affect the calcium channel activity

Takashi Murayama1, Nagomi Kurebayashi1, Toshiko Yamazawa2, Hideto Oyamada3, Junji Suzuki4, Kazunori Kanemaru4, Shigeru Takemori2, Katsuji Oguchi3, Masamitsu Iino4, Takashi Sakurai1
1Dept. Pharmacol., Juntendo Univ. Sch. Med, 2Dept Mol. Physiol., Jikei Univ. Sch. Med, 3Dept. Pharmacol., Sch. Med., Showa Univ, 4Dept. Pharmacol., Grad. Sch. Med., The Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 137-137, 2014.

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O3I-2-1 Establishment of a new strategy for promoting the adrenomedullin (AM) receptor resensitization

Kenji Kuwasako1, Kazuo Kitamura2, sayaka Nagata2, Johji Kato1
1Frontier Sci. Res. Center, Univ. of Miyazaki, 2Div. of Circl. and Body Fluid Reg., Faculty of Med., Univ. of Miyazaki
Journal of Pharmacological Sciences 124 (suppl) 138-138, 2014.

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O3I-2-2 Global identification of ECS(SPSB) E3 ligase substrates

Tadashi Nishiya, Ken Maruyama, Komei Takazawa, Kyohei Hamada, Takashi Uehara
Dept. Medicinal Pharmacol., Grad. Sch. of Med., Dent., and Pharmaceut. Sci., Okayama University
Journal of Pharmacological Sciences 124 (suppl) 138-138, 2014.

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O3I-2-3 The role of heparin-binding epidermal growth factor like growth factor (HB-EGF) on ocular angiogenesis

Yuki Inoue, Yuhei Hashimoto, Shinsuke Takata, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideaki Hara
Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University
Journal of Pharmacological Sciences 124 (suppl) 138-138, 2014.

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O3I-2-4 Functional analysis of Na+, K+, 2Cl- -cotransporters contributing to the endocochlear potential

Takamasa Yoshida1,2, Fumiaki Nin1, Genki Ogata1, Satoru Uetsuka1,3, Shizuo Komune2, Yoshihisa Kurachi4, Hiroshi Hibino1
1Dept Mol Physiol, Sch Med, Niigata Univ, 2Dept Otolaryngol, Grad Sch Med, Kyushu Univ, 3Dept Otolaryngol, Grad Sch Med, Osaka Univ, 4Dept Pharmacol Grad Sch Med, Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 138-138, 2014.

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O3I-2-5 Contributions of two force-generating mechanisms of hair cell to nonlinear amplification in the mammalian cochlea

Fumiaki Nin1, Tobias Reichenback2, JonathanAN Fisher2, AJ Hudspeth2
1Dept. Physiol. II, Niigata Univ. Sch. Med, 2Rockefeller University
Journal of Pharmacological Sciences 124 (suppl) 139-139, 2014.

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O3I-3-1 The effects of immunosuppressants on lung fibrosis

Risa Yamazaki1, Yasuo Matsuzawa2, Tatsuo Kawashima2, Madoka Yanagihara1, Hiroyuki Nakamura1, Hiromichi Fujino1, Toshihiko Murayama1
1Lab. Chemical Pharmaocol. Grad. Sch. Pharm. Sci. Chiba Univ, 2Dept. Int. Med. Toho Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 139-139, 2014.

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O3I-3-2 Development of airway clearance assessment of fluorescent beads

Teruya Ohba1, Eiji Sawada1, Yoshiaki Suzuki1, Hisao Yamamura1, Susumu Ohya1,2, Yuji Imaizumi1
1Dept. Mol. & Cell. Phamacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ, 2Dept. Pharmacol., Kyoto Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 139-139, 2014.

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O3I-3-3 The pharmacological evaluation of expectorant in mucous obstructive pulmonary disease mouse model

Tsuyoshi Shuto1, Yuki Sakaguchi1, Shunsuke Kamei1,2, Hirofumi Nohara1, Haruka Fujikawa1, Chizuru Matsumoto1, Tomomi Ono1, Mary Ann Suico1, Hirofumi Kai1,2
1Dept. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ, 2Prog. Leading Grad. Sch. HIGO Prog., Kumamoto Univ
Journal of Pharmacological Sciences 124 (suppl) 139-139, 2014.

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O3I-3-4 Blockade of IL-6 signal deteriorates bleomycin-induced lung injury

Takeshi Kobayashi1,2, Kensuke Tanaka1,2, Hiroyuki Amano1,2, Tetsuo Fujita1,2, Hiroki Umezawa1,2, Sadao Kimura1, Koichiro Tatsumi2, Yoshitoshi Kasuya1
1Dept. Biochemistry and Molecular Pharmacol., Chiba Univ.Sch.Med, 2Dept.Respirol., Chiba Univ. Sch.Med
Journal of Pharmacological Sciences 124 (suppl) 140-140, 2014.

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O3I-3-5 AQP5 expression enhances cytokine/chemokine expression by inflammatory stimuli in airway epithelial cells

Yuima Sakamoto1,2, Nao Egawa1, Ichiro Horie1, Akinori Hisatsune2, Hiroshi Katsuki2, Yoichiro Isohama1
1Lab.Applied Pharmacol., Faculty Pharm. Sci., Tokyo Univ.of Sci, 2Dept. Chemico-Pharm. Sci, .Grad.Sch.Pharm.Sci., Kumamoto Univ
Journal of Pharmacological Sciences 124 (suppl) 140-140, 2014.

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O3I-3-6 Antenatal glucocorticoid administration increases surfactant B production through the increase of CREB in a preterm infant lung

Yuko Takeba1, Yasushi Takagi2, Kenzo Sakurai3, Miniru Watanabe4, Sachiko Takenoshita1, Yuki Ohta1, Naoki Matsumoto1
1Dept. Pharmacol., St. Marianna Univ. Sch. Med, 2Dept Cardilol., St. Marianna Univ. Sch. Med, 3Dept. Pediatrics., St. Marianna Univ. Sch. Med, 4Inst. Exp. Animal, St. Marianna Graduate, Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 140-140, 2014.

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P1-1-1 Effects of prostaglandins on synaptic transmission in the rat spinal trigeminal subnucleus caudalis

Yuka Mizutani1,2, Yosiaki Ohi1, Miori Aoto1, Naoki Yoshida1, Satoko Kimura1, Ken Miyazawa2, Shigemi Goto2, Akira Haji1
1Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ, 2Dept. Orthdontics, Sch. Dent., Aichi Gakuin Univ
Journal of Pharmacological Sciences 124 (suppl) 142-142, 2014.

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P1-1-2 Simultaneous monitoring of neurotransmitters and prostanoids in rat hypothalamic PVN microdialyates

Fumio Kondo1, Masahiko Tachi1, Minoru Fukayama2, Kazuhiro Yoshikawa2, Shoshiro Okada1
1Dept. Pharmacol., Aichi Med. Univ. Sch. Med, 2Dept. Cent. Res. Lab., Aichi Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 142-142, 2014.

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P1-1-3 Intra-accumbal infusion of endomorphin-2 reduces acetylcholine efflux in the nucleus accumbens of freely moving rats

Yuri Aono1, Hiroko Taguchi2, Yuri Kiguchi3, Koji Takada4, Takahide Maeda3, Noriaki Koshikawa1, Tadashi Saigusa5
1Dept. Pharmacol., Nihon Univ. Sch. Dent, 2Dept. Orthodont., Nihon Univ. Sch. Dent, 3Dept. Ped. Dent., Nihon Univ. Sch. Dent. at Matsudo, 4Dept. Anaesthesiol., Nihon Univ. Sch. Dent, 5Dept. Pharmacol., Nihon Univ. Sch. Dent. at Matsudo
Journal of Pharmacological Sciences 124 (suppl) 142-142, 2014.

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P1-1-4 GABAA receptor modulates prefrontal DA release by both 5-HT1A and σ1 receptor activation

Naoki Hiramatsu1, Kazuya Mori1, Yuji Watabe1, Yukio Ago1, Kazuhiro Takuma1, Toshio Matsuda1,2
1Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci., Osaka Univ, 2Unit-Grad. Sch. of Child Dev., Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 142-142, 2014.

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P1-1-5 Enhancement of CRE-mediated transcription and ChAT gene expression by the extract from fermented Citrus reticulate peel with Aspergillus kawachii and its constituent in culture

Tatsuya Suzuki1, Kusano Shuichi2, Ichiro Kawahata1, Hiroshi Tamura2, Md Al Rahim3, Tohru Yamakuni1
1Dept. Pharmacother., Grad. Sch. Pharmaceu. Sci., Tohoku Univ, 2FUJI SANGYO CO., LTD. Res. and Develop. Center, 3Dept. Neurol. Johns Hopkins Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 143-143, 2014.

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P1-1-6 Apomorphine-induced circling behavior in the common marmoset pretreated with subcutaneously given MPTP and that with hemi-brain infused 6-OHDA

Chiyoko Nishime1, Sayaka Ohba2,4, Eiko Nishinaka1,4, Ryo Inoue1, Takashi Inoue2, Kenji Kawai3, Hideki Tsutsumi1, Toshio Ito2, Kiyoshi Ando2
1Dept. Testing., CIEA, 2Dept.Marmoset Res., CIEA, 3Patho., Analysis Center, 4JAC Inc
Journal of Pharmacological Sciences 124 (suppl) 143-143, 2014.

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P1-1-7 FABP3 promotes α-Syn oligomerization in dopaminergic neurons

Misaki Onozato1, Norihumi Shioda1, Yasushi Yabuki1, Yuji Owada2, Kohji Fukunaga1
1Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci, 2Dept. Organ Anatomy, Yamaguchi Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 143-143, 2014.

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P1-1-8 Aripiprazole, a dopamine D2 receptor partial agonist activates nuclear CaMKII in dopaminergic neurons

Masahiro Sawai, Norifumi Shioda, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ., Grad. Sch. Pharma. Sci
Journal of Pharmacological Sciences 124 (suppl) 143-143, 2014.

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P1-2-1 The subcellular localization and local function of Gs-linked receptor GPR3 in neuronal cells

Tatsuhiro Miyagi, Shigeru Tanaka, Izumi Hide, Toshihiko Shirafuji, Norio Sakai
Dept. Mol and Pharmacol Neurosci., Hiroshima Univ. Grad Sch. Biomed and Health Sci
Journal of Pharmacological Sciences 124 (suppl) 144-144, 2014.

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P1-2-2 Overexpression of hippocampal cholinergic neurostimulating peptide facilitates long-term potentiation in the CA1 region of mice

Yoshiaki Ohi1, Daisuke Kato2, Masayuki Mizuno2, Satoko Kimura1, Noriyuki Matsukawa2, Akira Haji1
1Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ, 2Dept. Neurol., Grad. Sch. Med. Sci., Nagoya City Univ
Journal of Pharmacological Sciences 124 (suppl) 144-144, 2014.

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P1-2-3 Expressions of hemoglobin and a hemoglobin-derived peptide in pre-sympathetic neurons of the rat hypothalamic paraventricular nucleus following the central administration of bombesin

Kenjiro Tanaka, Takahiro Shimizu, Keisuke Taniuchi, Kumiko Nakamura, Kunihiko Yokotani, Motoaki Saito
Dept. Pharmacol., Kochi Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 144-144, 2014.

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P1-2-4 Gene expression patterns of BCL2-related proteins in hypothyroid embryonic chick cerebellum

Yui Inomata, Yu Tezuka, natsumi Herai, Keisuke Kagami, Hideo Nishigori, Atsushi Sanbe
Dept. Pharmacotherap.., Iwate Medi. Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 144-144, 2014.

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P1-2-5 Voltage-dependency of TRPV1 channel

Hideo Miyamoto1, Yoshiya Takayanagi2, Kentarou Araki1, Teruyuki Yanagisawa2, Minoru Wakamori1
1Dept. Mol. Pharmacol. & Cell Biophys., Tohoku Univ. Grad. Sch. Dent, 2Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 145-145, 2014.

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P1-2-6 High fat diet induces pathological change in hypothalamic orexin neurons

Mizuki Nobunaga1, Kanae Obukuro1, Yuki Kurauchi2,3, Akinori Hisatsune2,3, Takahiro Seki1, Masato Tsutsui4, Hiroshi Katsuki1
1Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci. Kumamoto Univ, 2Priority Organization for Innovation and Excellence, Kumamoto Univ, 3Program for Leading Graduate Schools HIGO Program, Kumamoto Univ, 4Dept, pharmacol., Grad. Sch. Med. Ryukyu Univ
Journal of Pharmacological Sciences 124 (suppl) 145-145, 2014.

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P1-2-7 Analysis of intracellular calcium mobilization induced by heavy metals using fura-2 and TPEN in SH-SY5Y cells

Masato Ohkubo, Atsushi Miyamoto, Mitsuya Shiraishi
Dept. Vet. Pharmacol., Kagoshima Univ
Journal of Pharmacological Sciences 124 (suppl) 145-145, 2014.

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P1-2-8 Expression analysis of amino acid transporter LAT1 in mouse development

Tomohisa Katada1, Masami Kanai-Azuma2, Yoshikatsu Kanai3, Hitoshi Endou4, Hiroyuki Sakurai1
1Dept. Pharmacol. and Toxicol., Kyorin Univ. Sch. Med, 2Dept. Lab. Animal, Tokyo Med. and Dent. Univ, 3Bio-system Pharmacol., Dept. Pharmacol., Osaka Univ. Grad. Sch. Med, 4J-Pharma Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 145-145, 2014.

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P1-3-1 Simulation analysis of K+ buffering in astrocyte

Shingo Murakami, Yoshihisa Kurachi
Dept. Pharmacol., Osaka Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 146-146, 2014.

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P1-3-2 Effect of brefelamide on HGF-induced cell survival in 1321N1 human astrocytoma cells

Sachina Takasaka, Takahiro Shibuya, Takahiro Ishikawa, Shigeyoshi Honma, Makoto Yoshida
Dept. Pathophysiol., Fac. Pharmacy, Takasaki University of Health and welfare
Journal of Pharmacological Sciences 124 (suppl) 146-146, 2014.

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P1-3-3 Mitochondrial calcium signaling in Schwann cells mediates myelination in the peripheral nervous system

Daisuke Ino1, Hiroshi Sagara2, Junji Suzuki1, Kazunori Kanemaru1, Yohei Okubo1, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med. Univ. Tokyo, 2Medical Prateomics Laboratory, Institute of Medical Science, Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 146-146, 2014.

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P1-3-4 Prostacyclin promotes oligodendrocyte precursor recruitment and remyelination after lysophosphatidylcholine-mediated demyelination in the adult spinal cord

Rieko Muramatsu1,2,3, Chisato Takahashi1,2, Toshihide Yamashita1,2
1Dept. Mol. Neurosci., Grad. Sch. Med., Osaka Univ, 2JST-CREST, 3JST-PRESTO
Journal of Pharmacological Sciences 124 (suppl) 146-146, 2014.

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P1-3-5 Assesment of cell death induced by oxidative stress in cultured astrocytes

Koh-ichi Tanaka1,2,3, Nobue Kitanaka2, Junichi Kitanaka2, Junya Hanatani1, Shyohko Asano1, Erika Toumoto1, Tomoaki Sato3, Takashige Nishikawa3, Motohiko Takemura2, Akemichi Baba1, Nobuyoshi Nishiyama1
1Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci, 2Dept. Pharmacol., Hyogo Col. Med, 3Dept. Applied Pharmacol., Kagoshima Univ. Grad. Sch. Med. & Dent. Sci
Journal of Pharmacological Sciences 124 (suppl) 147-147, 2014.

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P1-3-6 Astrogliosis begins at presymptomatic stages in a mouse model of Sandhoff disease

Takafumi Sano1, Yasuhiro Ogawa1, Hitoshi Sakuraba2, Kazuhiko Oishi1
1Dept. Pharmacol., Meiji Pharmaceutical Univ, 2Dept. Clin. Genetics, Meiji Pharmaceutical Univ
Journal of Pharmacological Sciences 124 (suppl) 147-147, 2014.

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P1-3-7 Contribution of bone marrow-derived cells to the population of spinal microglia after peripheral nerve injury

Daisuke Tomiyama, Makoto Tsuda, Kazuhide Inoue
Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 147-147, 2014.

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P1-3-8 AQP4 dependent up-regulated expression of TN-C and GFAP in activated astrocytes

Hiroko Ikeshima-Kataoka1,2, Yoichiro Abe1, Sayaka Inui1, Masato Yasui1
1Dept. Pharmacol. & Neurosci., Keio Univ. Sch. Med, 2Faculty of Science & Engneering, Waseda Univ
Journal of Pharmacological Sciences 124 (suppl) 147-147, 2014.

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P1-3-9 High-mobility group box 1 increases aquaporin 4 in astrocytes through interleukin-1β produced by microglia in rat brain

Masatoshi Ohnishi, Ayaka Monda, Ryoko Takemoto, Yukina Fujimoto, Mitsumasa Sugitani, Takahiro Iwamura, Takashi Hiroyasu, Atsuko Inoue
Dept. Pharmacotherapeut., Fukuyama Univ. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 148-148, 2014.

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P1-3-10 EP4 receptor-associated protein (EPRAP) in microglia promotes inflammation in the central nervous system

Risako Fujikawa1, Manabu Minami1,2, Sei Higuchi2, Mika Yasui1, Taichi Ikedo1, Manabu Nagata1, Masayuki Yokode1,2
1Dept. Clin. Innov. Med., Grad. Sch. of Med., iACT Room 131 Kyoto University Hospital, 2Dept. Clin. Innov. Med. Inst. Adv. Clin. Trans. Sci. Kyoto Univ. Hosp., iACT Room 131 Kyoto University Hospital
Journal of Pharmacological Sciences 124 (suppl) 148-148, 2014.

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P1-4-1 Involvement of trombospondin 1 on cerebroprotective effect of ADAMTS13 in brain injury after transient focal cerebral ischemia

Masayoshi Tanaka1, Keiichi Irie2, Takafumi Nakano1,3, Kaori Kubota1, Shutaro Katsurabayashi1, Kotaro Takasaki1, Koujirou Futagami3, Kenichi Mishima1,2, Katsunori Iwasaki1,2
1Dept. Neuropharmacology, Faculty of Pharmaceutical Sciences. Fukuoka. Univ, 2A.I.G. Collaborative Research Institute for Aging and Brain Sciences, 3Dept.Pharmacy, Fukuoka University Hospital
Journal of Pharmacological Sciences 124 (suppl) 148-148, 2014.

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P1-4-2 Protective effects of ferulic acid against chronic cerebral hypoperfusion-induced swallowing dysfunction in rats

Hirokazu Matsuzaki1, Takashi Asano1, Yukari Nakata1, Yuta Yokose1, Naohiro Iwata2, Yasuhide Hibino2, Mari Okazaki1
1Pharmacol., Fac. Pharm. Sci., Josai Univ, 2Immunobiochem., Fac. Pharm. Sci., Josai Univ
Journal of Pharmacological Sciences 124 (suppl) 148-148, 2014.

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P1-4-3 Induction of Microsomal prostaglandin E synthase-1 expression contributes to increase in prostaglandin E2 production in the hemorrhagic brain

Chika Yozawa1, Saki Kawano1, Yasuhito Naito1, Shun Watanabe1, Takashi Iwai1, Satoshi Uematsu2, Shizuo Akira3, Mitsuo Tanabe1, Yuri Ikeda-Matsuo1
1Lab. Pharmacol., Sch. Pharmac. Sci., Kitasato Univ, 2Div. Innate immune regulation, Int. Res. Dev. Center for Mucosal Vaccine, Insti. Med. Sci., Univ. Tokyo, 3Lab. Host Defense, Immunol. Front. Res. Center, Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 149-149, 2014.

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P1-4-4 Investigation of the development of cerebral infarction using multi-modal imaging

Kazuya Hokamura1, Yasuhiro Magata2, Mikako Ogawa2, Takahiro Natsume3, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med, 2Medical Photonics Res. Cent., Hamamatsu Univ. Sch Med, 3Collab. Cent. Med. Innov., Hamamatsu Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 149-149, 2014.

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P1-4-5 Y-secretase Elicits Vasoprotective Effect via Reduces the Ubiquitination and Degradation of Occludin during Brain Ischemia

Wei-feng Ye1, Rong-rong Tao2, Feng Han2
1Department of Pharmacy, The Affiliated Children's Hospital, Zhejiang University School of Medicine, 2Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 149-149, 2014.

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P1-4-6 Prx1 protects endothelial cells from ER stress-mediated injury following ischemia insult

Rong-rong Tao1, Nan-nan Lu1, Ji-Yun Huang1, Huan Wang1, Mei-hua Liao1, Wei-feng Ye2, Feng Han1
1Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, 2The Children's Hospital, Zhejiang University School of Medicine
Journal of Pharmacological Sciences 124 (suppl) 149-149, 2014.

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P1-4-7 Microglial M1/M2 balance in a motor disease rat model

Kimino Kawaguchi, Kuniko Kusama-Eguchi
Dept. Biochem., Nihon Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 150-150, 2014.

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P1-4-8 Neuroprotective effects of levetiracetam in parkinsonian model mice

Ikuko Miyazaki1, Shinki Murakami1, Nao Torigoe2, Yoshihisa Kitamura2, Masato Asanuma1
1Dept. of Brain Sci., Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci, 2Dept. of Clinical Pharmacy, Okayama Univ. Grad. Sch. of Med., Dent. and Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 150-150, 2014.

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P1-4-9 A sarin-like reagent induces endoplasmic reticulum (ER) stress and apoptosis on human astrocytoma derived cells

Hiroaki Shiraishi1, Yousuke Arima1, Akira Namera1, Kanji Yoshimoto1,2, Masataka Nagao1
1Dept. Forensic Med., Hiroshima Univ. Inst. Biomed. Health Sci, 2Dept. Food Sci. and Biotech. and Health, Hiroshima Inst. Tech
Journal of Pharmacological Sciences 124 (suppl) 150-150, 2014.

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P1-4-10 Pathologieal changes in rat cortex and hippocampus after intraperitoneal injection of LPS-induced brain inflammation

Yihan Zhang, Yuan Dou, Xiangnan Zhang, Yan Liu, Liangyan He, Danyan Zhu, Yijia Lou
Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 150-150, 2014.

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P1-5-1 Exendin-4 promotes the membrane trafficking of the AMPA-GluR1 and ADAM10 in mouse neocortex

Nobuaki Ohtake, Mieko Saito, Masaaki Eto, Kenjiro Seki
Dept. Pharmacol., School of Pharmaceutical Science, Ohu University
Journal of Pharmacological Sciences 124 (suppl) 151-151, 2014.

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P1-5-2 Parkin activation via protein kinase CK2 by ROS

Masahiko Watabe1,2, Toshio Nakaki1
1Dept. Pharmacol. Teikyo Univ. Sch..Med, 2G-MEC
Journal of Pharmacological Sciences 124 (suppl) 151-151, 2014.

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P1-5-3 Systemic LPS administration induced behavioral impairment of motor function

Sachiko Tanaka, Riki Yoshikawa, Kaoru Murakami, Toru Yagi, Satoshi Numazawa
Div. Toxicol., Showa Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 151-151, 2014.

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P1-5-4 Synapse vulnerability induced by Amyloid β-derived diffusible ligands is blocked by the inhibitor of histone deacetylase

Yuta Ishizuka1, Hideo Shimizu1, Eiko Takagi1, Mai Kato1, Masahiko Mikuni2, Tomoaki Shirao1
1Dept. Neurobiol & Behav, Gunma Univ Grad Sch Med, 2Dept. Psychiatry & Neurosci, Gunma Univ Grad Sch Med
Journal of Pharmacological Sciences 124 (suppl) 151-151, 2014.

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P1-5-5 SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models

Yoko Ono1, Hirotaka Tanaka1, Masafumi Takata1, Yuki Nagahara1, Yasuhiro Noda1, Kazuhiro Tsuruma1, Masamitsu Shimazawa1, Isao Hozumi2, Hideaki Hara1
1Mol. Pharmacol. Dept. Biofunct. Eval., Gifu Pharmaceut. Univ, 2Dept of Med Ther and Mol Ther, Gifu Pharmaceut Univ
Journal of Pharmacological Sciences 124 (suppl) 152-152, 2014.

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P1-5-6 Relationship between the neuroprotective effects of α1D adrenoceptor antagonist and the striatal glutamate level in methamphetamine-injected rats

Kazue Kikuchi-Utsumi, Nobuko Matsumura, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 152-152, 2014.

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P1-5-7 Induction of neuronal cell death through S-nitrosylation of the type 1 ryanodine receptor

Yoshinori Mikami1, Kazunori Kanemaru1, Yasuhiro Oda1, Akihiro Ito2, Sho Kakizawa3, Toshiko Yamazawa4, Nobuhito Saito2, Masamitsu Iino1
1Dept. Pharmacol., Grad. Sch. Med., The Univ. Tokyo, 2Dept. Neurosurg., Grad. Sch. Med., The Univ. Tokyo, 3Dept. Biol. Chem., Grad. Sch. Pharmaceu. Sci., Kyoto Univ, 4Dept. Mol. Physiol., Jikei Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 152-152, 2014.

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P1-5-8 Osteopontin/CD44 pathway in a mouse model of amyotrophic lateral sclerosis

Kosuke Onishi1, Yasuhiro Moriwaki1, Mamiko Niikura1, Yuta Morisaki1, Koji Yamanaka2,3, Hidemi Misawa1
1Dept. Pharmacol., Keio Univ. Fac. Pharm, 2RIKEN BSI, 3Research Institute of Environmental Medicine, Nagoya Univ
Journal of Pharmacological Sciences 124 (suppl) 152-152, 2014.

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P1-5-9 The analysis of endosomal proteins, which specifically interact with APP-βCTF

Nobumasa Takasugi, Runa Araya, Yuji Kamikubo, Takashi Sakurai
Dept. Pharmacol., Juntendo Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 153-153, 2014.

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P1-6-1 Inhibition of phosphodiesterase relieves morphine-induced ventilatory depression without loss of analgesia

Satoko Kimura, Yuuki Miura, Yoshiaki Ohi, Akira Haji
Lab. Neuropharmacol., Sch. Pharm., Aichi Gakuin Univ
Journal of Pharmacological Sciences 124 (suppl) 153-153, 2014.

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P1-6-2 Transient receptor potential ankyrin 1 that is induced in dorsal root ganglion neurons contributes to cold hyperalgesia after oxaliplatin administration

Kyouji Taguchi1, Ken Yamamoto1, Noriko Chiba1, Mayuko Tsuboi1, Toshie Kambe2, Iku Utsunomiya3, Kenji Abe4
1Dept. Medicinal Pharmacol., Showa Pharma. Univ, 2Dept. Pharmacol., Showa Pharma. Univ, 3Dept. Pharmacothera., Showa Pharma. Univ, 4Dept. Pharmacol., Ohu. Univ
Journal of Pharmacological Sciences 124 (suppl) 153-153, 2014.

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P1-6-3 miR-17-92 cluster upregulation in the dorsal root ganglion in neuropathic pain

Atsushi Sakai, Hidenori Suzuki
Dept. Pharmacol., Nippon Med. Sch
Journal of Pharmacological Sciences 124 (suppl) 153-153, 2014.

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P1-6-4 Involvement of T-type Ca2+ channels in the novel cognitive enhancer ST101-induced facilitation of neurite outgrowth in NG108-15 cells and hyperalgesia in mice

Sumire Ohno1, Daiki Kanaoka1, Hiroki Ide1, Fumiko Sekiguchi1, Shigeru Yoshida2, Kohji Fukunaga3, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm, 2Dep. Life Sci., Kinki Univ. Sch. Engineer, 3Dep. Pharmacology, Graduate Sch. Pharmaceutical Sciences, Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 154-154, 2014.

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P1-6-5 The antinociceptive effect of opioid analgesics in neuropathic cancer pain

Ryou Sugawara1, Hirokazu Mizoguchi1, Chizuko Watanabe1, Akihiko Yonezawa1, Syu-ichi Kanno3, Masaaki Ishikawa3, Hiroshi Nagase2, Shinobu Sakurada1
1Dept. Physiol. Anat. Tohoku Pharmaceut. Univ, 2Dept. Med. Chem, IIIS, WPI, Tsukuba Univ, 3Dept. Clin. Pharmacother. Tohoku Pharmaceut. Univ
Journal of Pharmacological Sciences 124 (suppl) 154-154, 2014.

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P1-6-6 Inactivation of HMGB1 with its neutralizaing antibody and recombinant human soluble thrombomodulin suppresses paclitaxel-induced neuropathy in rats and mice

Yudai Kawaishi1, Hiroki Yamanishi1, Maho Tsubota1, Fumiko Sekiguchi1, Takeshi Nishida1,2, Hiroyasu Ishikura2, Masahiro Nishibori3, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm, 2Dept. Emerg. Crit. Care Med., Fac. Med., Fukuoka Univ, 3Dept. Pharmacol., Okayama Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 154-154, 2014.

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P1-6-7 Activation of muscarinic M1 receptors in the anterior cingulate cortex inhibit the nociception via GABAnergic system

Kenji Honda, Yu Matsuzaki, Ryo Saito, Yukio Takano
Dept. Physiol. and Pharmacol., Fac. Pharm. Sci. fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 154-154, 2014.

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P1-6-8 Involvement of nociceptive TRPA1 channel in analgesic action of Limonene

Tatsuki Kaimoto1, Kenji Takahashi1, Shigeru Saito2, Makoto Tominaga2, Toshio Ohta1
1Dept. Vet. Pharmacol., Fac. Agr, Tottori Univ, 2Dev. of Cell Signaling, NIPS
Journal of Pharmacological Sciences 124 (suppl) 155-155, 2014.

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P1-6-9 Inhibitory effects of cholinergic drugs on hyperalgesia in three different experimental pain models in mice

Yoshiharu Yamanishi, Yukio Takamatsu, Kazutaka Ikeda
Res. Proj. Addictive Sub., Tokyo Metro. Insti. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 155-155, 2014.

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P1-7-1 Molecular strucure of nAChR ligand(2)

Taizou Hayano1, Shiroh Kishioka2, Hiroyuki Yamamoto2
1Div.Psychiatry.asahikaiwakaurabyouin, 2Dept. Pharmacol., Wakayama, Med.Sch.Med
Journal of Pharmacological Sciences 124 (suppl) 155-155, 2014.

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P1-7-2 An evaluation of the utility of preclinical PK/PD analysis using small-animal PET in drug discovery process

Yosuke Nakatani1, Michiyuki Suzuki2, Norihito Oi2, Miyuki Sakai2, Hiroki Ishihara2, Takashi Yoshinaga2, Osamu Takenaka2, Masaki Tokunaga3, Jun Maeda3, Ming-Rong Zhang3, Makoto Higuchi3, Tetsuya Suhara3
1DMPK Japan., Eisai Co., Ltd, 2Tsukuba Research Lab. Eisai Co., Ltd, 3Molecular Imaging Center, Natl. Inst. Radiol. Sci
Journal of Pharmacological Sciences 124 (suppl) 155-155, 2014.

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P1-7-3 Effects of the interaction of addicsin and Tomoregulin-1 on cell migration

Mitsushi Ikemoto1,2, Taku Arano1,2, Shingo Fujisaki2
1Biomedical Res. Inst., AIST, 2Grad. Sch. of Sci., Toho Univ
Journal of Pharmacological Sciences 124 (suppl) 156-156, 2014.

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P1-7-4 Mechanism of body temperature regulation by the central nervous system during arousal from hibernation in Syrian hamsters

Mayuko Monden1, Hirohito Shiomi1, Yutaka Tamura1,2
1Dept.Pharmacol., Fac. Pharm. & Pharmaceutical Sci. Fukuyama Univ, 2Res. Center for Green Sci., Fukuyama Univ
Journal of Pharmacological Sciences 124 (suppl) 156-156, 2014.

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P1-7-5 Centrally administered angiotensin II elevates plasma adrenaline level by brain angiotensin AT1 receptor-mediated mechanisms in the rat

Kumiko Nakamura, Takahiro Shimizu, Kenjiro Tanaka, Keisuke Taniuchi, Motoaki Saito
Dept. Pharmacol., Kochi Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 156-156, 2014.

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P1-7-6 Lamotrigine inhibits mouse Nav1.4 voltage-gated sodium channel current

Yoshihiko Nakatani1,2, Hiroshi Takeda1, Taku Amano2
1Div. Pharmacol., Sch. Pharm., Internat. Univ. Health and Welfare, 2Div. Pharmacother., Sch. Pharm., Internat. Univ. Health and Welfare
Journal of Pharmacological Sciences 124 (suppl) 156-156, 2014.

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P1-7-7 Endogenous retinoid signaling after intracerebral hemorrhage in mice

Hideaki Matsushita1, Masanori Hijioka1, Hayato Ishibashi1, Junpei Anan1, Yuki Kurauchi2,3, Akinori Hisatsune2,3, Takahiro Seki2,3, Koichi Shudo4, Hiroshi Katsuki1
1Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci. Kumamoto Univ, 2Priority Organization for Innovation and Excellence, Kumamoto Univ, 3Program for Leading Graduate Schools HIGO Program, Kumamoto Univ, 4Res. Fdn.ITSUU Lab
Journal of Pharmacological Sciences 124 (suppl) 157-157, 2014.

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P1-8-1 Effects of substrate elasticity on contractile properties of human induced pluripotent stem cell-derived cardiomyocytes

Miki Fujizuka1, Junko Kurokawa1, Hatsume Uno2, Yuji Nakai3, Shushi Nagamori4, Yoshikatsu Kanai4, Yasunari Kanda5, Eriko Matsui2, Tetsushi Furukawa1
1Dept. Bio-Informational Pharmacol., MRI, Tokyo Med. Dent. Univ, 2Sony Corporation, 3Dept. Applied Bio-Chemistry, Agulicul., The Univ. of Tokyo, 4Bio-System Pharmacol., Osaka Univ. Grad. Sch. Med, 5Div. Pharmacol., Natl. Inst. Hlth. Sci
Journal of Pharmacological Sciences 124 (suppl) 157-157, 2014.

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P1-8-2 Fluvastatin, an HMG-CoA reductase inhibitor, facilitate adenosine production in the rat hearts via activation of ecto-5'-nucleotidase

Toshio Obata
yokkaichi Nursing and medical care University
Journal of Pharmacological Sciences 124 (suppl) 157-157, 2014.

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P1-8-3 Celecoxib and 2,5-dimethyl-celecoxib inhibit cardiac hypertrophy induced by transverse aortic constriction in mice

Ai Fujita1,2, Fumi Takahashi1, Sachio Morimoto1, Toshiyuki Sasaguri1
1Dept. Clin. Pharmacol. Fac. Med. Sci., Kyushu Univ, 2Dept. Anesthesiology, Kyushu Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 157-157, 2014.

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P1-8-4 MAP kinase TNNI3K functional analysis and new drug development for suppressing cardiac sudden death

Zhong-Fang Lai1, Yu-Zhen Chen1, Tian-Li Zhang2, Nobuo Sakaguchi2, Shokei Kim-Mitsuyama1, Yasunori Kitamoto3
1Dept. Pharmacol.Mol. Therap., Grad. Sch., Kumamoto Univ, 2Dept. Immunology, Grad. Sch, Kumamoto Univ, 3Sendai Shakaihoken Hosp
Journal of Pharmacological Sciences 124 (suppl) 158-158, 2014.

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P1-8-5 Activation of G protein-coupled estrogen receptor (GPER/GPR30) ameliorates myocardial ischemia/ reperfusion-induced cardiac dysfunction and norepinephrine overflow

Tatsuya Sawano1, Masashi Tawa2, Takeshi Koyama1, Tomoyo Wada1, Mamoru Ohkita1, Yasuo Matsumura1
1Lab. Pathol. and Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci, 2Dept. Pharmacol., Shiga Univ. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 158-158, 2014.

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P1-8-6 Cardioprotective effects of geranylgeranylacetone via enhanced induction of heat shock protein 72 after myocardial infarction in rats

Shiho Nagata, Tetsuro Marunouchi, Satomi Inomata, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci
Journal of Pharmacological Sciences 124 (suppl) 158-158, 2014.

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P1-8-7 Changes in heat shock protein B8 in the mitochondria of the failing heart following myocardial infarction in rats

Shoko Tamura, Tetsuro Marunouchi, Satomi Inomata, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci
Journal of Pharmacological Sciences 124 (suppl) 158-158, 2014.

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P1-8-8 Effects of cardiac progenitor cell transplantation on impairment of the mitochondrial respiration after myocardial infarction in rats

Tetsuro Marunouchi, Iori Tsuchiya, Mikiko Tsuda, Mami Ishihara, Emi Yano, Kouichi Tanonaka
Dept. Mol. Cell. Pharmacol., Tokyo Univ. Pharm, Life Sci
Journal of Pharmacological Sciences 124 (suppl) 159-159, 2014.

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P1-8-9 Changes in regulation of Cav1.2 Ca2+ Channel by Calpastatin in Myocardial Hypoxic-Ischemic Injury

Huiyuan Hu1, Deri Sun2, Yan Zhao1, Shuang Liu3, Liying Hao1
1Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, 2Department of Orthopaedics Surgery, The Fourth Affiliated Hospital of China Medical University, 3Department of Cardiovascular Function, The First Affiliated Hospital of China Medical University
Journal of Pharmacological Sciences 124 (suppl) 159-159, 2014.

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P1-9-1 Significant roles for K+ channels and cytochrome P450 (CYP) epoxygenase metabolites in the relaxant effects of docosahexaenoic acid (DHA) on the rat thoracic aorta contracted with TXA2 receptor (TP receptor) stimulation

Kyosuke Sato, Nanako Nishioka, Keisuke Kanai, Mika Aoki, Keisuke Obara, Daisuke Chino, Yoshio Tanaka
Dept. Chem. Pharmacol., Toho Univ. Sch. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 159-159, 2014.

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P1-9-2 Nesfatin-1, a novel adipocytokine, stimulates proliferation of vascular smooth muscle cells

Yuki Hayabe, Tatsuya Usui, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 159-159, 2014.

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P1-9-3 Effects of vaspin, an adipocytokine on contractility of rat isolated mesenteric artery

Kensuke Yamada, Tomoka Morita, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 160-160, 2014.

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P1-9-4 Mechanisms underlying impaired desensitization of proteinase-activated receptor 1 (PAR1)

Katsuya Hirano, Mayumi Hirano
Dept. Mol. Cardiol., Grad. Sch. Med. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 160-160, 2014.

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P1-9-5 Scorpion toxin modulates P2X receptor activation in rat cerebral artery myocyte

Hiromitsu Morita1, Shohei Yoshimoto1,2, Kazuki Sato3, Yushi Ito4, Masato Hirata2
1Special Patient Oral Care Unit, Kyushu Univ. Hosp, 2Lab. of Mol. Cell. Biochem., Fac. of Dent. Sci., Kyushu Univ, 3Dept. of Environment. Sci., Fukuoka Women's Univ, 4Res. Div. for Life Sci., Kumamoto Health Sci. Univ
Journal of Pharmacological Sciences 124 (suppl) 160-160, 2014.

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P1-9-6 Investigation of phenotypic change on primary rat aortic vascular smooth muscle cell by cyclic strain and stimulation of vasoactive substances

Yukiko Kondo, Naoko Matsushita, Yasuyuki Irie, Eiichi Taira
Dept. Pharmacol., Iwate Medical Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 160-160, 2014.

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P1-9-7 The role of smooth muscle cells specific HIF-1α in pulmonary hypertension in mice

Michiyo Iguchi1, Noriko Tomita4, Masaki Imanishi2, Hirotsugu Kurobe3, Noriko Sugasawa3, Itaru Satoh1, Shinji Matsunaga1, Toshiaki Tamaki2, Shuhei Tomita1
1Div. Mole Pharmacol., Tottori Univ. Sch. Med, 2Dept. Pharmacol., Tokushima Univ. Sch. Med, 3Dept. Cardiovasc Surg., Tokushima Univ. Sch. Med, 4Dept. Mole Med and Therap., Tottori Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 161-161, 2014.

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P1-9-8 Effects of fatty acid-binding protein(FABP)4 on proliferation of vascular smooth muscle cell

Akihiro Sekiguchi, Kyosuke Kazama, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 161-161, 2014.

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P1-9-9 Involvement of inward rectifying K+ channel (Kir2.1) in vascular tone regulation of mesenteric artery in renovascular hypertensive mice

Minami Hattori1, Fumito Maruyama1, Yoshiaki Suzuki1, Hisao Yamamura1, Susumu Ohya2, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ, 2Dept. Pharmacol., Kyoto Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 161-161, 2014.

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P1-9-10 Acylated butenolide derivative inhibits smooth muscle contraction by suppressing phosphorylation of MYPT1

Shinya Masuda1, Seigo Ito1, Satoshi Kanai1, Shin-ya Saito1, Haruhisa Kikuchi2, Yoshiteru Oshima2, Tomohisa Ishikawa1
1Grad Sch Pharm, Univ Shizuoka, 2Chem., Grad. Sch. Pharm. Sci., Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 161-161, 2014.

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P1-10-1 Effect of Na+/Ca2+ -exchanger 1 inhibitor on noise-induced hearing loss

Kiyokazu Ogita1, Taro Yamaguchi1, Toshio Matsuda2, Akemichi Baba3
1Dept. pharmacol., Setsunan Univ, 2Lab. Med. Pharmacol., Grad. Sch. Pharm., Osaka Univ, 3Dept. Pharmacol., Hyogo Univ. Health Sci
Journal of Pharmacological Sciences 124 (suppl) 162-162, 2014.

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P1-10-2 Change in the expression level of aquaporin in the inner ear of Slc26a4-/- mice

Taro Yamaguchi1, Yosuke Tona2, Norio Yamamoto2, Takayuki Nakagawa2, Juichi Ito2, Masanori Yoneyama1, Kiyokazu Ogita1
1Dept. Pharmacol., Setsunan Univ, 2Kyoto Univ., Grad. School. Med
Journal of Pharmacological Sciences 124 (suppl) 162-162, 2014.

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P1-10-3 Functional analysis of choline transporters in nasal polyp fibroblasts

Masato Inazu1,2, Hanae Konishi1, Risa Suzuki1, Sho Onodera1, Takayoshi Tomita1, Tsuyoshi Yamanaka2, Manabu Nonaka3
1Institute of Medical Science, Tokyo Med. Univ, 2Dept. Mol. Preventive Med., Tokyo Med. Univ, 3Dept. Otolaryngology, Tokyo Women's Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 162-162, 2014.

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P1-10-4 The cell migration and invasion using Real Time Cell Analyzer and martix metalloproteinases in head and neck cancers

Takeshi Hayashi1, Shinichi Iwai2, Kenichiro Kawaguchi1, Takehiko Sanbe1, Syunya Egawa1, Tomohiro Ono1, Katsuji Oguchi1
1Dept. Phamacol., Showa Univ. Sch. Med, 2Dept. Health and Regulatory Sciences., Showa Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 162-162, 2014.

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P1-10-5 Effect of apelin deficiency on upregulation of fibronectin expression in a mouse model of ischemic retinopathy

Yuki Ishimaru, Sachi Aichi, Chihiro Kobayashi, Hideki Fujiwara, Ai Sugimoto, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ
Journal of Pharmacological Sciences 124 (suppl) 163-163, 2014.

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P1-10-6 The protective effects of astaxanthin on neuronal damage after retinal ischemia and reperfusion

Tomohiro Otsuka1, Masamitsu Shimazawa1, Yuki Inoue1, Yusuke Nakano1, Kazuki Ojino1, Kazuhiro Tsuruma1, Takashi Ishibashi2, Hideaki Hara1
1Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 2JX Nippon Oil & Energy Corporation
Journal of Pharmacological Sciences 124 (suppl) 163-163, 2014.

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P1-10-7 Existence of the compensatory proliferation mechanism in the UV-irradiated human conjunctival epithelium cells

Eiji Tomoyori, Yuko Udaka, Mayumi Tsuji, Akiko Sasaki, Katsuji Oguchi
Dept.Pharmacol., Shwa Univ.Sch.Med
Journal of Pharmacological Sciences 124 (suppl) 163-163, 2014.

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P1-11-1 A novel indole compound, AWT-489, inhibits prostaglandin D2 -induced CD55 expression by acting on DP prostanoid receptors as an antagonist

Hiromichi Fujino1, Satomi Oyama1, Yamazaki Risa1, Iori Okura1, John.W.Regan2, Atsuko Awata3, Takayoshi Arai3, Toshihiko Murayama1
1Lab. Chem. Pharmacol., Gard. School of Pharmaceutical Sci. Chiba Univ, 2Dept. Pharm/Tox, College of Pharmacy, The Univ. of Arizona, 3Dept. Chemistry, Gard. School of Sci. Chiba Univ
Journal of Pharmacological Sciences 124 (suppl) 163-163, 2014.

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P1-11-2 Hetero-oligomerization and functional interaction between purinergic receptors expressed in platelets to regulate platelet shape change

Tokiko Suzuki1, Naomi Okuda1, Hiroyasu Nakata2, Takahiro Moriya1
1Dept. Cell. Signal., Grad. Sch. Pharm. Sci., Tohoku Univ, 2Tokyo Metro. Inst. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 164-164, 2014.

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P1-11-3 JosD1, a deubiquitinating enzyme, regulates membrane dynamics, cell motility and endocytosis

Takahiro Seki1,2,3, Sokol V.Todi4, Norio Sakai2, Henry L.Paulson3, Hiroshi Katsuki1
1Dept. Chemico-Pharmacol. Sci., Grad. Sch. Pharm. Sci., Kumamoto Univ, 2Dept. Mol. Pharmacol. Neurosci., Grad. Sch. Biomed. Sci., Hiroshima Univ, 3Dept. Neurol., Univ. of Michigan, 4Dept. Pharmacol. Neurol., Wayne State Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 164-164, 2014.

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P1-11-4 Allosteric modulation by Na+ of the affinity of ligands for human histamine H1 receptors in Chinese hamster ovary cells

Kiyoe Kosaka1, Chizuru Akatsu1, Hiroyuki Fukui2, Shigeru Hishinuma1, Masaru Shoji1
1Dept. Pharmacodyn., Meiji Pharm. Univ, 2Dept. Mol. Pharmacol., Grad. Sch. Health Biosci., Univ. Tokushima
Journal of Pharmacological Sciences 124 (suppl) 164-164, 2014.

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P1-11-5 Agonist-induced internalization of human histamine H1 receptor is regulated by its C-terminal

Hiroki Nozawa, Chizuru Akatsu, Shigeru Hishinuma, Masaru Shoji
Dept. Pharmacodyn., Meiji Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 164-164, 2014.

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P1-11-6 L-Ascorbic acid- and L-ascorbic acid 2-glucoside-induced hepatocyte mitogenesis are mediated by IGF-I receptor tyrosine kinase/MAP kinase pathway

Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara
Dept. Clin. Pharmacol., Fac. Pharm. Sci. Josai Univ
Journal of Pharmacological Sciences 124 (suppl) 165-165, 2014.

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P1-11-7 Staurosporine maintains the activation of store-operated Ca2+ entry even after the refilling of Ca2+ stores

Yosuke Tojyo1, Takao Morita2, Akihiro Nezu2, Akihiko Tanimura2
1Labo. Biophysics, Sch. Dent., Health Sci. Univ. Hokkaido, 2Dept. Pharmacol., Sch. Dent., Health Sci. Univ. Hokkaido
Journal of Pharmacological Sciences 124 (suppl) 165-165, 2014.

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P1-11-8 Role of cAMP-PKA signaling in oligodendrogenesis from NSCs

Risa Fujii, Tomoko Maekawa, Tokiko Suzuki, Takahiro Moriya
Dept. Cell. Signal., Grad. Sch. Pharm. Sci., Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 165-165, 2014.

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P1-11-9 Inhibitory and excitatory effects of hydrogen sulfide on RIN14B cells

Ayako Ujike, Ken-ichi Otsuguro, Ryo Miyamoto, Soichiro Yamaguchi, Shigeo Ito
Lab. Pharmacol., Grad. Sch. Vet. Med. Hokkaido Univ
Journal of Pharmacological Sciences 124 (suppl) 165-165, 2014.

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P1-11-10 Involvement of NF-kB in the expression of the WD repeat containing protein 35

Gou-Gang Feng, Lei Huang, Naoshisa Ishikawa, Fumio Kondo, Shoshiro Okada
Dept. Pharmacol., Aichi Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 166-166, 2014.

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P1-12-1 Suppression of limbic Fos protein expression by intermittent hypoxia in obese diabetic mice

Yukihiro Ohno1, Takahiro Mukai1, Yuki Nagao1, Tetsuya Hayashi2, Satoshi Nishioka3, Saki Shimizu1, Sho Watanabe1, Yoko Ueda1, Madoka Hara1, Ryuji Kato2, Yasuo Matsumura3
1Lab. Pharmacol., Osaka Univ. Pharm. Sci, 2Osaka Univ. Pharm. Sci., Lab. Cardiovascular Pharmacother. Toxicol, 3Osaka Univ. Pharm. Sci., Lab. Path. Mol. Pharmacol
Journal of Pharmacological Sciences 124 (suppl) 166-166, 2014.

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P1-12-2 Comparison of three rat models of bladder overactivity induced by neurological disorders

Tomomi Oyama1, Junko Suzuki1, Yoshitaka Itani1, Maho Noguchi1, Hiroyuki Takamatsu1, Kazuo Umemura2
1Hamamatsu Pharma Research, Inc, 2Dept. Pharmacol., Hamamatsu Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 166-166, 2014.

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P1-12-3 Purinergic bladder contraction and ATP release

Azuki Sakai1, Erina Konno1, Saki Matsumoto1, Tsunetaka Ito2, Yumi Katano1, Akira Ishihata1
1Dept. Pathophysiol., Yamagata Univ. Sch. Med, 2Yamagata Univ
Journal of Pharmacological Sciences 124 (suppl) 166-166, 2014.

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P1-12-4 P2Y6 receptors plays a critical role in bladder storage function in mice

Satoru Kira1, Mitsuharu Yoshiyama1, Tatsuya Miyamoto1, Hiroshi Nakagomi1, Tsutomu Mochizuki1, Eiji Shigetomi2, Masayuki Takeda1, Schuichi Koizumi2
1Dept. Urology., Yamanashi Univ, 2Dept. Pharmacology., Yamanashi Univ
Journal of Pharmacological Sciences 124 (suppl) 167-167, 2014.

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P1-12-5 Prediction of Potential of PET Ligand Candidates by LC-MS/MS

Kazumi Koga1,2,3, Masaki Tokunaga2, Kazunori Kawamura2, Jun Maeda2, Mari Ohmichi1, Ming-Rong Zhang2, Makoto Higuchi2, Tetsuya Suhara2
1Discov.Pharmacol.1, Mol.Func.Pharmacol.Labs., Taisho Pharmaceutical Co., Ltd, 2Mol. Imag. Center, National Institute of Radiological Sciences, 3Grad. Sch. Med., Tohoku Univ
Journal of Pharmacological Sciences 124 (suppl) 167-167, 2014.

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P1-12-6 A novel method for analysis of aggressiveness using female mice

Toshiko Kuchiiwa1, Osamu Murakami2, Kae Miura1, Satoshi Kuchiiwa3
1Dept.Clinical Psych., Grad.Sch.Human Sci., Kagoshima Immaculate Heart Univ, 2Muromachi Kikai Co. Ltd, 3Dept.Neuroanat., Grad.Sch.Med.Dent.Sci., Kagoshima Univ
Journal of Pharmacological Sciences 124 (suppl) 167-167, 2014.

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P1-12-7 A novel single double-conditional short-hairpin RNA expression vector

Hideto Oyamada, Tomoyuki Matsuoka, Ayami Inagaki, Katsuji Oguchi
Dept. Pharmacol., Showa Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 167-167, 2014.

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P1-12-8 Development of cell-selective Ca2+ imaging technique with caged small-molecule Ca2+ probe

Shunsuke Kishi1, Daisuke Asanuma1, Yasuteru Urano2, Kenzo Hirose1
1Dept. Neurosci., Grad. Sch. Med. The Univ. of Tokyo, 2Dept. Radiol, and Biomed. Eng., Grad. Sch. Med. The Univ. of Tokyo
Journal of Pharmacological Sciences 124 (suppl) 168-168, 2014.

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P1-12-9 Development and validation of RP-HPLC method for simultaneous estimation of glimepiride and sildenafil citrate in bulk-application to pharmacokinetic studies in rats

A.S.Tripathi1, Irshad Sheikh1, A.P.Dewani2, P.G.Shelke3, R.L.Bakal2, A.V.Chandewar3, Papiya Mitra Mazumder4
1Department of pharmacology, P. Wadhwani college of Pharmacy, 2Deparment of Quality assurance, P. Wadhwani college of Pharmacy, 3Deparment of Pharmaceutical chemistry, P. Wadhwani college of Pharmacy, 4Department of Pharmaceutical sciences, Birla Institute of technology
Journal of Pharmacological Sciences 124 (suppl) 168-168, 2014.

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P1-13-1 Role of P2X7 receptor-mediated signaling in human B cell like myeloma RPMI8226 cells

Kazuki Yoshida, Masa-aki Ito, Isao Matsuoka
Lab. Phamacol. Facul. Pharm. Takasaki Univ. Health and Welfare
Journal of Pharmacological Sciences 124 (suppl) 168-168, 2014.

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P1-13-2 Rac-ERK pathway mediates histamine-induced chemotaxis of mouse mast cells

Atsuo Kuramasu1, Mie Wakabayashi2, Takeshi Honda1, Saaya Koguchi1, Yurie Higuchi1, Makoto Inui1, Kazuhiko Yanai2
1Dept. Pharmacol., Yamaguchi Univ. Sch. Med, 2Dept. Pharmacol., Tohoku Univ. Sch, Med
Journal of Pharmacological Sciences 124 (suppl) 168-168, 2014.

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P1-13-3 Endothelin regulates function of IL-17-producing T cell subset

Kensuke Tanaka1,2, Kento Yoshioka1, Koichiro Tatsumi2, Sadao Kimura1, Yoshitoshi Kasuya1
1Dept. biochem. Mol. Pharmacol, 2Dept. Respirol. Chiba Univ
Journal of Pharmacological Sciences 124 (suppl) 169-169, 2014.

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P1-13-4 Evaluation of anti-inflammatory property of cilostazol in LPS-induced acute lung injury

Takuya Sakamoto, Kengo Tomita, Michinori Takashina, Wakana Ohashi, Yuichi Hattori
Dept, of Mol. Med. Pharmacol., Graduate sch. of Med. and Pharm., Univ. of Toyama
Journal of Pharmacological Sciences 124 (suppl) 169-169, 2014.

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P1-13-5 Altered miRNA expression associated with enhanced skin inflammation induced by TPA in type 2 diabetic db/db mice

Kosuke Itoh, Mizuki Yamasaki, Osamu Aozasa, Yoshinori Iba
Dept. Life Science., Setsunan Univ. Fac. Sci. and Engineering
Journal of Pharmacological Sciences 124 (suppl) 169-169, 2014.

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P1-13-6 The potential of histidine rich glycoprotein supplementary therapy for sepsis

Hidenori Wake1, Shuji Mori2, Hideo K Takahashi3, Keyue Liu1, Kiyoshi Teshigawara1, Masahiro Nishibori1
1Dept. Pharmacol., Okayama Univ. Grad. Sch. Med., Dent. & Pharm. Sci, 2Shujitsu Univ. Sch. Pharm, 3Dept. Pharmacol., Kinki Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 169-169, 2014.

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P1-13-7 Increased IL-17C production by the TLR3 ligand poly(I:C) in primary cystic fibrosis airway epithelial cells

Keiko Ueno-Shuto1, Tsuyoshi Shuto2, Yukihiro Tasaki2, Kouhei Onuki2, Mary Ann Suico2, Yuji Uchida1, Naofumi Tokutomi1, Hirofumi Kai2
1Lab. Pharmacol., Sojo Univ. Pharm. Sch, 2Dept. Mol. Med., Grad. Sch. Pharm. Sci., Kumamoto Univ
Journal of Pharmacological Sciences 124 (suppl) 170-170, 2014.

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P1-14-1 15-deoxy-Δ12, 14-prostaglandin J2 enhanced anti-tumor effects of topoisomerase II inhibitors against renal cell carcinoma

Takehiro Yamamoto1, Michika Kubo1, Kaori Tamura1, Eri Shimada1, Yuta Hyuga1, Suzuha Tanaka1, Shunta Satoi1, Kazunori Murakami2, Asako Oya2, Seiya Hisamura2, Yuma Kobayashi2, Yasuhiro Yamamoto2, Hiromi Koma2, Tatsurou Yagami2
1Gen. Sci. Dept., Hyogo Pref. Kobe High Sch, 2Dept. Physiol., Fac. Pharmaceut. Sci., Himeji Dokkyo Univ
Journal of Pharmacological Sciences 124 (suppl) 170-170, 2014.

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P1-14-2 Effectiveness of microRNA expressions and PARP inhibitors for triple-negative breast cancer with BRCA1 mutations

Akiko Sasaki1, Yuko Tsunoda2, Mayumi Tsuji1, Yuko Udaka1, Hideto Oyamada1, Katsuji Oguchi1
1Dept. Pharmacol., Showa Univ.Sch.Med, 2Breast Center, Kameda Medical Center
Journal of Pharmacological Sciences 124 (suppl) 170-170, 2014.

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P1-14-3 Expression of miRNA of the Glioblastoma cancer stem cells after the radiation exposure

Takatoshi Tokudome, Akiko Sasaki, Mayumi Tsuji, Yuko Udaka, Hideto Oyamada, Katsuji Oguchi
Dept.Phrmacol., Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 170-170, 2014.

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P1-14-4 The Role of PRMT5 in RASSF1A-mediated tumor suppressive functions

Yumiko Saito, Nobuya Sakai, Katsushi Shibata
Dept. Pharmacol., Himeji Dokkyo Univ
Journal of Pharmacological Sciences 124 (suppl) 171-171, 2014.

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P1-14-5 Impairment of DNA-PKcs phosphorylation induces tumorigenesis in mouse

Shinji Matsunaga1, Shichuan Zhang2, Shogo Shimizu1, Shuhei Tomita1, Benjamin Chen.P.C2
1Div. Mol. Pharmacol., Tottori Univ. Sch. Med, 2Divi. Mol. Rad. Biol., Dep. Rad. Onc., UTSW. Med. Ctr
Journal of Pharmacological Sciences 124 (suppl) 171-171, 2014.

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P1-14-6 Chloroquine enhances temozolomide cytotoxicity in glioma cells by inducing mitochondrial ROS via blocking mitochondrial autophagy

Atsushi Kuno, Yusuke Hori, Ryusuke Hosoda, Yoshiyuki Horio
Dept. Pharmacol., Sapporo Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 171-171, 2014.

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P1-14-7 Organoantimony compounds induce cell cycle arrest in human acute promyelocytic leukemia cell line via cdk-cyclin pathway

Taisuke Nakamura1, Naoki Kakusawa3, Mio Matsumura2, Syuji Yasuike2, Tatuo Yagura1
1Dept. Bio Sci., Kwangaku Univ. Facul.Sci.Tech, 2Sch.Pharm.Sci.Aichigakuin Univ, 3Facul. Pharm. Sci. Hokuriku Univ
Journal of Pharmacological Sciences 124 (suppl) 171-171, 2014.

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P1-15-1 Effect of compound X for working memory performance and amyloid-β protein in mice

Kensuke Iwasa1, Hui Tan2, Sayaka Midorikawa1, Miku Nemoto1, Asami Mizushima1, Keisuke Yoshikawa1, Kuniyoshi Shimizu2, Kei Maruyama1
1Dept. Pharmacol., Saitama Med Univ. Sch. Med, 2Dept. agro-environmental sciences, Faculty of Agriculture, Graduate School of Kyushu University
Journal of Pharmacological Sciences 124 (suppl) 172-172, 2014.

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P1-15-2 The effects of perinatal exposure to genistein, a soy isoflavones, on the learning and memory performance in offspring rats

Yumi Kohara1, Rika Kuwahara2, Shinichiro Kawaguchi2, Takeshi Jojima1, Kimihiro Yamashita1, 2
1Grad. Sch. Fish. Sci. Env. Stu, 2Grad. Sch. Sci. Technol
Journal of Pharmacological Sciences 124 (suppl) 172-172, 2014.

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P1-15-3 Effect of chitosan oligosaccharides on the activity of cyclooxygenase

Rie Terasawa1, Yuichi Koike2, Naomasa Yamamoto3, Norihumi Yonehara1
1Dept. Dent. Pharmacol., Ohu Univ. Sch. Dent, 2Dept. Drug Metab. and Clini. Pharmacokinetics., Ohu Univ. Sch. Pharm, 3Dept. Biochem., Ohu Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 172-172, 2014.

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P1-15-4 Study on pharmacological effects of Punica gramatum extracts on animal endoparasites

Thanh Hai Nguyen1, Thi Thanh Ha Nguyen2, Mitsuya Shiraishi2, Atsushi Miyamoto2
1Dept. Plant Biotechnol., Hanoi Univ. of Agriculture, Trau Quy commune, Gia Lam district, 2Dept. Vet. Pharmaco., Kagoshima Univ., Kagoshima prefecture
Journal of Pharmacological Sciences 124 (suppl) 172-172, 2014.

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P1-15-5 Protective effect of Gynura Procumbens(Lour.)Merr on DEN-induced liver injury in mice

Xiao-Jun Li, Ting-Ting Li, Yan-Ling Yang, Yu-sang Li, He-Bin Tang
Dept. Pharmacol., S Cent Univ Nationalities, Coll Pharm
Journal of Pharmacological Sciences 124 (suppl) 173-173, 2014.

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P1-15-6 Improvement of insulin resistance by Mingdou jangtang tablet

Yu-sang Li, Xiao-Jun Li, Ting-Ting Li, Yan-Ling Yang, He-Bin Tang
Dept. Pharmacol., S Cent Univ Nationalities, Coll Pharm
Journal of Pharmacological Sciences 124 (suppl) 173-173, 2014.

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P1-15-7 Kampo prescription improved anxiety-like behavior via increase of brain-derived neurotrophic factor

Ai Nogami1, 2, Kotaro Takasaki2, kaori Kubota2, Hiraku Yamashita2, Kaori Yamamoto2, Yuuna Takao2, Naoki Uchida3, Shutaro Katsurabayashi2, Kenichi Mishima1,2, Michihiro Fujiwara2, Ryoji Nishimura3, Katsunori Iwasaki1,2
1Institute for Aging and Brain Sciences, Fukuoka Univ, 2Dept. Neuropharmacology., Fukuoka Univ. Sch. Pharm. Sci, 3Dept. Psychiatry., Fukuoka Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 173-173, 2014.

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P1-15-8 CD44 on human head and neck squamous cell carcinoma (HNSCC) was stimulated by baicalin and baicalein included traditional herbal medicines (Kampo medicines) classified into Bupleurum root drugs

Emika Ohkoshi1, Naoki Umemura2, Hiroshi Sakagami2
1MPL. Meikai Univ. Sch. Dent, 2Dept. Pharmacol., Meikai Univ. Sch. Dent
Journal of Pharmacological Sciences 124 (suppl) 173-173, 2014.

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P1-15-9 Butein inhibits angiogenesis of human endothelial progenitor cells via the translation dependent signaling pathway

Yu-Wei Lai1, Shiou-Sheng Chen1, Shih-Wei Wang2
1Division of Urology, Taipei City Hospital Renai Branch, 2Department of Medicine, Mackay Medical College
Journal of Pharmacological Sciences 124 (suppl) 174-174, 2014.

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P1-15-10 Neural signal cascade of ginseng/ginsenosides on protein kinase

Wenbin He, Naihong Chen
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization, Ministry of Education)
Journal of Pharmacological Sciences 124 (suppl) 174-174, 2014.

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P1-16-1 Suppressive effect of Rosmarinic acid on tumor growth and cancer invasion in human oral squamous cell carcinoma

Akina Omori, Yoshitaka Yoshimura, Yoshiaki Deyama, Kuniaki Suzuki
Dept. Molecul. Cell Pharmacol., Hokkaido Univ. Grad. Sch. Den. Med
Journal of Pharmacological Sciences 124 (suppl) 174-174, 2014.

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P1-16-2 Designing of new cytotoxic isoquinolines against human oral squamous cell carcinoma cell lines (Part 3)

Mariko Ishihara
Div. Basic Chem., Meikai Uiv. Sch. Dent
Journal of Pharmacological Sciences 124 (suppl) 174-174, 2014.

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P1-16-3 Insulin sensitization by a PPARy partial agonist with PTP1B inhibitory activity in experimental osteoporotic rats

Masahiro Kubo1,2, Masaki Fukui1, Yuma Ito1, Tatsuya Kitao1, Hiroaki Shirahase1, Eiichi Hinoi2, Yukio Yoneda2
1Research Laboratories., Kyoto Pharmaceutical Industries. Ltd, 2Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 175-175, 2014.

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P1-16-4 Effect of Protamine Hydrolysate Peptide against Radiation Mucositis in Mice

Takashi Shinomiya1, Masanobu Yoshikawa1,2, Shigetoshi Okumura3, Mitsuru Kawaguchi1, Migiwa Okubo1
1Dept. Pharmacol., Tokyo Dent. Coll, 2Clin. Pharmacol., Tokai Univ. Sch. Med, 3ROHTO Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 175-175, 2014.

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P1-16-5 Intragingival injection of Porphyromonas gingivalis-derived lipopolysaccharide transiently increases gingival extracellular TNF-α levels of anaesthetised rats

Hiroko Taguchi1, Yuri Aono2, Takayuki Kawato3, Masatake Asano4, Noriaki Koshikawa2, Tadashi Saigusa5
1Dept. Orthodont., Nihon Univ. Sch. Dent, 2Dept. Pharmacol., Nihon Univ. Sch. Dent, 3Dept. Oral Health Sci., Dent., Nihon Univ. Sch. Dent, 4Dept. Pathol., Nihon Univ. Sch. Dent, 5Dept. Pharmacol., Nihon Univ. Sch. Dent. at Matsudo
Journal of Pharmacological Sciences 124 (suppl) 175-175, 2014.

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P1-16-6 The inhibitory mechanism of eugenol on TRPV1 channel

Takashi Yoshida1, Kaori Takahashi2, Minoru Wakamori1
1Div. Mol. Pharmacol. and Cell Biophys., Dept. Oral. Biol. Tohoku Univ. Grad. Sch. of Dent, 2Tohoku Univ. Sch. of Dent
Journal of Pharmacological Sciences 124 (suppl) 175-175, 2014.

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P1-16-7 Identification of IDH3 as a novel target of tributyltin by metabolomics

Shigeru Yamada1, Yaichiro Kotake2, Yuko Sekino1, Yasunari Kanda1
1Div. Pharmacol., NIHS, 2Grad. Sch. Biomed. Health Sci., Hiroshima Univ
Journal of Pharmacological Sciences 124 (suppl) 176-176, 2014.

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P1-16-8 Investigating free radical generation in HepG2 cells induced by aromatic amine compounds using immuno-spin trapping

Yuya Horinouchi1, 2, Fiona.A. Summers3, Marilyn Ehrenshaft3, Koichiro Tsuchiya4, Toshiaki Tamaki2, Ronald.P. Mason3
1Dept. Pharm., Tokushima Univ. Hosp, 2Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch, 3Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, 4Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 176-176, 2014.

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P1-16-9 Effects of mukuna on cultured rat embryos

Atsushi Yokoyama
Kanagawa Life-Sciense Res
Journal of Pharmacological Sciences 124 (suppl) 176-176, 2014.

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P2-1-1 Inhibitory effect of serotonin on the glutamatergic transmission onto cholinergic neurons in the basal forebrain of the rat

Takuma Nishijo1,2, Toshihiko Momiyama1
1Dept. Pharmacol., Jikei Univ. Sch of Med, 2Dept. Pharmacol., Keio Univ. Sch of Pharm
Journal of Pharmacological Sciences 124 (suppl) 176-176, 2014.

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P2-1-2 Loss of dopaminergic neuron enhanced the cytokine production in the mouse brain

Yuta Sugino, Yasuhiro Yoshioka, Shogo Kotera, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ
Journal of Pharmacological Sciences 124 (suppl) 177-177, 2014.

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P2-1-3 Molecular mechanism of dopamine-induced activation of intracellular D2L receptor

Eriko Ishida, Norifumi Shioda, Kohji Fukunaga
Dept. Pharmacol., Tohoku Univ. Grad. Sch. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 177-177, 2014.

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P2-1-4 Increase of Y5 receptor mRNA expression in hypothalamic nuclei of NPY Y1 receptor knockout mice

Tomohiro Shiiya, Shin-ichi Murase, Hiroshi Higuchi
Div.Pharmacol., Mol. Cell. Med., Niigata Univ., Grad. Sch. Med. Den. Sci
Journal of Pharmacological Sciences 124 (suppl) 177-177, 2014.

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P2-1-5 Developmental impairment of catecholaminergic system in mice induced by prenatal nicotine exposure

Yuki Aoyama1, Daisuke Kihara2, Tursun Alkam2, Kazuya Toriumi2, Taku Nagai1, Takayoshi Mamiya2,4, Masayuki Hiramatsu2,4, Toshitaka Nabeshima3,4, Kiyofumi Yamada1,4
1Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med, 2Dept. Chem. Pharmcol., Meijo Univ. Fac. Pharm, 3Dept. Region. Pharmaceuti. Care Sci., Meijo Univ. Fac. Pharm, 4Japanese Drug Organi. Appropri. Use Research
Journal of Pharmacological Sciences 124 (suppl) 177-177, 2014.

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P2-1-6 Development of a glutamate optical sensor for visualizing synaptic transmission

Kenji Takikawa, Shigeyuki Namiki, Hirokazu Sakamoto, Testuro Ariyoshi, Naoya Kinpara, Daisuke Asanuma, Kenzo Hirose
Dept. Neurobiol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 178-178, 2014.

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P2-1-7 Analysis of mouse polyspecific transporters

Yamato Miura, Takeo Yoshikawa, Fumito Naganuma, Tadaho Nakamura, Attayeb Mohsen, Tomomitsu Iida, Kazuhiko Yanai
Dept. Pharmacol., Tohoku Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 178-178, 2014.

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P2-2-1 Muller cells induce axonal elongation of retinal ganglion cells via P2Y6 receptor activation

Masanori Taguchi1, Youichi Shinozaki1, Kenji Kashiwagi2, Shuichi Koizumi1
1Dept. Neuropharmacol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi, 2Dept. Ophthalmol., Interdisciplinary Grad. Sch. Med. and Engineering, Univ. Yamanashi
Journal of Pharmacological Sciences 124 (suppl) 178-178, 2014.

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P2-2-2 Vascular endothelial cells promote cortical neurite outgrowth by a mechanism dependent on integrin beta 3

Satoko Sumimoto1,2,3, Rieko Muramatsu1,2,3, Sakiko Fujii2,3, Toshihide Yamashita1,2,3
1Dep. Molecular Neuroscience, Osaka Univ.Sch. Med, 2CREST, 3PRESTO
Journal of Pharmacological Sciences 124 (suppl) 178-178, 2014.

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P2-2-3 Proapoptotic effect of inorganic pyrophosphatase 1 in hypothyroid embryonic chick cerebellum

Yu Tezuka1, Natsumi Herai1, Yui Inomata1, Keisuke Kagami1, Junji Yamauchi2, Hideo Nishigori1, Atsushi Sanbe1
1Dept. Pharmacotherap..., Iwate medi. Univ. Sch. Pharm, 2National Center for Child Health and Development
Journal of Pharmacological Sciences 124 (suppl) 179-179, 2014.

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P2-2-4 Role of chondroitin sulfate in the modulation of neuronal morphology

Naoki Sotogaku1, Masato Tsutsui2, Akinori Nishi1
1Dept. Pharmacol. Kurume Univ. Sch. Med, 2Dept. Pharmacol. Univ. Ryukyus. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 179-179, 2014.

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P2-2-5 Regulatory mechanisms of nicotine-induced IP3R-1 expression via CaMKIV activation

Koji Mizuno, Kazuhiro Kurokawa, Seitaro Ohkuma
Dept. Pharmacol., Kawasaki Med. Sch
Journal of Pharmacological Sciences 124 (suppl) 179-179, 2014.

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P2-2-6 ERK2-Mediated Phosphorylation of Par3 Regulates Neuronal Polarization

Yasuhiro Funahashi, Takashi Namba, Shin Fujisue, Norimichi Itoh, Shinichi Nakamuta, Katsuhiro Kato, Akiko Shimada, Chundi Xu, Tomoki Nishioka, Kozo Kaibuchi
Dept. Cell Pharmacol., Nagoya Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 179-179, 2014.

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P2-2-7 The role of uncoupling protein-2 in glutamate neurotoxicity with ischemia

Ryo Fukumori1,2, Takeshi Takarada2, Yukio Yoneda2
1Dept. Pharmacol., Nagasaki Int Univ. Sch. pharm, 2Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch. Nat. Sci. Tech
Journal of Pharmacological Sciences 124 (suppl) 180-180, 2014.

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P2-2-8 Neuroprotective effects of Bacosides on ischemia-induced neuronal cell damage in organotypic hippocampal slice culture

Xoan Thi Le1, Hang Thi Nguyet Pham2, Tai Van Nugyen2, Phuong Thi Nugyen2, Ken Tanaka3, Kinzo Matsumoto1
1Divi. Med. Pharmacol., Inst. Natural Med., Univ. Toyama, 2Vietnam Nat. Inst. Med. Materials, 3Div. Pharmacog., Inst. Natural Med., Univ. Toyama
Journal of Pharmacological Sciences 124 (suppl) 180-180, 2014.

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P2-3-1 Brain cannabinoid CB1 receptors are suppressively involved in central activation of sympatho-adrenomedullary outflow induced by bombesin microinjected into the rat hypothalamic paraventricular nucleus

Takahiro Shimizu1, Kenjiro Tanaka1, Kumiko Nakamura1, Keisuke Taniuchi1, Shogo Shimizu2, Toshio Yawata3, Youichirou Higashi3, Tetsuya Ueba3, Kunihiko Yokotani1, Motoaki Saito1
1Dept. Pharmacol., Kochi Univ. Sch. Med, 2Div. Mole. Pharmacol., Tottori Univ. Sch. Med, 3Dept. Neurosurg., Kochi Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 180-180, 2014.

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P2-3-2 Relationship between mechanism of action and the nature of drug interaction by type I isobolographic analysis

Nobuko Matsumura, Toshio Nakaki
Dept.Pharmacol., Teikyo Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 180-180, 2014.

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P2-3-3 Development of novel activators for TRPC channels aiming to treatment of neurodegenerative disorders

Seishiro Sawamura1, Masahiko Hatano1, Yoshinori Takada1,2, Takashi Kuwamura1, Tomohiro Numata1,3, Shigeki Kiyonaka1,3, Kyosuke Hino2, Tetsuya kawamura2, Jun Tanikawa2, Hiroshi Nakagawa2, Ryu Nagata2, Ryuji Inoue4, Yasuo Mori1,3
1Kyoto Univ., Dept. Synth. Chem. & Biol. Chem., Grad. Sch. Engineer, 2Dainippon Sumitomo Pharma Co., Ltd, 3Kyoto Univ., Dept. Technol. & Ecol., Hall Global Environment Kyoto, 4Dept. Physiol., Grad. Sch. Med., Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 181-181, 2014.

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P2-3-4 Regulation of cell surface expression of histamine H3 receptor by an ER protein DRiP78

Junjie Jin, Kazuki Kinoshita, Takeya Sato, Teruyuki Yanagisawa, Jun Sukegawa
Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 181-181, 2014.

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P2-3-5 Analysis of Rab proteins interacting with histamine H3 receptor

Hoda Bagheri, Junjie Jin, Nadine Lusamba Kalonji, Takeya Sato, Teruyuki Yanagisawa, Jun Sukegawa
Dept. Mol. Pharmacol., Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 181-181, 2014.

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P2-3-6 The balance between BMP and TGF-β signaling at an early stage steers serotonergic differentiation from ES cells

Atsushi Yamasaki1,2, Atsushi Kasai1,3, Akihiro Toi1, Maki Kurita1, Atsuko Hayata-Takano4, Kazuki Nagayasu2, Norihito Shintani1, Akemichi Baba5, Hitoshi Hashimoto1,2,4
1Lab. Mol. Neuropharm., Grad. Sch. Pharmaceut. Sci., Osaka Univ, 2iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, 3Interdisciplinary Program for Biomedical Sciences, Institute for Academic Initiatives, Osaka Univ, 4Center Child Mental Dev., Unit. Grad. Sch.Child Dev., Osaka Univ, 5Pharmaceut. Sci., Hyogo Univ. of Health Sci
Journal of Pharmacological Sciences 124 (suppl) 181-181, 2014.

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P2-3-7 Methamphetamine effects on iPad touch response reinforced by audiovisual stimulus in the common marmoset

Ryo Inoue1, Sayaka Ooba2,3, Chiyoko Nishime1, Eiko Nishinaka1,2, Takashi Inoue3, Hideki Tsutsumi1, Toshio Itoh3, Kiyoshi Ando3
1Testing Department, Central Institute for Experimental Animals, 2JAC Inc, 3Testing Department, Central Institute for Experimental Animals
Journal of Pharmacological Sciences 124 (suppl) 182-182, 2014.

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P2-3-8 Effects of nonylphenol on the learning and memory performance in adult male rats

Shinichiro Kawaguchi1, Rika Kuwahara1, Yumi Kohara2, Takeshi Jojima2, Kimihiro Yamashita3,4
1Grad. Sch. Sci. Technol., Nagasaki Univ, 2Grad. Sch. Fish. Sci. Env. Stu., Nagasaki Univ, 3Grad. Sch. Fish. Sci. Env. Stu., Nagasaki Univ
Journal of Pharmacological Sciences 124 (suppl) 182-182, 2014.

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P2-4-1 Involvement of endplasmic reticulum stress in autism spectrum disorder

Koichi Kawada1, Takaaki Iekumo1, Ryo Saito1, Masayuki Kaneko2, Yasuyuki Nomura3, Yasunobu Okuma1
1Dept. Pharmacol., Chiba Inst. Sci, 2Lab. Med. Therap. and Mol. Therap., Gifu Pharmaceutical Univ, 3Dept. Pharmacol., Kurume Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 182-182, 2014.

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P2-4-2 Prenatal nicotine exposure inhibits neurogenesis in the prefrontal cortex and induces behavioral abnormalities

Akane Shimato1, Yuki Aoyama1,2, Tursun Alkam1, Kazuya Toriumi1, Taku Nagai2, Takayoshi Mamiya1,4, Kiyofumi Yamada2,4, Toshitaka Nabeshima3,4, Masayuki Hiramatsu1,4
1Dept. Chem. Pharmacol., Fac. Pharm., Meijo Univ, 2Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med, 3Dept. Region. Pharmaceuti. Care Sci., Fac. Pharm., Meijo Univ, 4Japanese Drug Organi. Appropri. Use Research
Journal of Pharmacological Sciences 124 (suppl) 182-182, 2014.

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P2-4-3 Effects of low-dose methylphenidate on attention-deficit hyperactivity disorder (ADHD)-like behaviors in the spontaneously hypertensive rat, an animal model of ADHD

Yuki Kishikawa1,3, Yukie Kawahara1, Makiko Yamada1, Hiroshi Kawahara2, Akinori Nishi1
1Dept. Pharmacol., Kurume Univ. Sch. Med, 2Dept. Pharmacol., Tsurumi Univ. Sch. Dent, 3Dept.of PT, YIC Reha. Col
Journal of Pharmacological Sciences 124 (suppl) 183-183, 2014.

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P2-4-4 The intronic SNP of PCLO is associated with dependence-like behavior in genomic association syudy, and regulates DA and 5-HT uptake in the cultured cells

Kyosuke Uno1, Daisuke Nishizawa2, Seunghee Seo1,3, Kanako Takayama1, Shohei Matsumura1, Norio Sakai4, Kazutaka Ohi5, Toshitaka Nabeshima6, Hashimoto Ryota5,7, Norio Ozaki8, Kazutaka Ikeda2, Yoshiaki Miyamoto1, Atsumi Nitta1
1Dept of Pharm Therapy and Neuropharmacol, Fac of Pharm Sci, Grad Sch of Med & Pharm Sci, Univ of Toyama, 2Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 3Dept of Pharmaceutical Education, Fac of Pharm Sci, Grad Sch of Med & Pharm Sci, Univ of Toyama, 4Dept of Mole Pharm Neuroscience, Inst of Biomedi and Health Sci, Hiroshima Univ, 5Dept of Psy, Osaka Univ Grad Sch of Med, 6Dept of Regional Pharmaceutical Care and Sciences, Grad School of Pharma Sci, Meijo University, 7Mol Res Cen for Child Mental Develop, Univ Grad Sch of Child Develop, Osaka Univ, 8Dept of Psychiatry, Grad School of Med, Nagoya University
Journal of Pharmacological Sciences 124 (suppl) 183-183, 2014.

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P2-4-5 Anxiety and schizophrenia-like behaviors induced by TMEM168 overexpression in the nucleus accumbens of mice

Kequan Fu1, Yoshiaki Miyamoto1, Eriko Saika1, Shin-ichi Muramatsu2, Kyosuke Uno1, Atsumi Nitta1
1Dept of Pharm Therapy and Neuropharmacol, Fac of Pharm Sci, Grad Sch of Med & Pharm Sci, Univ of Toyama, 2Division of Neurology, Dept of Med, Jichi Medical Univ
Journal of Pharmacological Sciences 124 (suppl) 183-183, 2014.

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P2-4-6 The reduction of methylation on the upstream reagion of shati/nat8l transcription start site is induced by repeated administration of methamphetamine

Toh Miyazaki1, Kyosuke Uno1, Yuu Kikuchi1, Yoko Hibi2, Toshitaka Nabesima3, Toshiaki Miyamoto1, Atsumi Nitta1
1Dept of Pharm Therapy and Neuropharmacol, Fac of Pharm Sci, Grad Sch of Med and Pharm Sci, Univ of Toyama, 2Dept of Neuropsychopharmacol and Hosp Pharm, Nagoya Univ Grad Sch of Med, 3Dept of Neuropsychopharmacol and Hosp Pharm, Nagoya Univ Grad Sch of Med
Journal of Pharmacological Sciences 124 (suppl) 183-183, 2014.

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P2-4-7 Evaluation of autonomic nervous balance in women with climacteric symptoms

Nobuyuki Yanagihara1, Meikan Seki1, Masahiro Nakano2, Toru Hachisuga3, Yukio Goto4
1Dept. Pharmacol., Univ. Occup. & Env. Health. Sch. Med, 2Dept. Nursing, Fac. Health Sci., Junshin Gakuen Univ, 3Dept. Obstetr. Gynecol., Univ. Occup. & Env. Health, Sch. Med, 4Dept. Anesthesiol., Aichi Med. Univ., Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 184-184, 2014.

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P2-5-1 Inhibitory effect of α4β2 nicotinic acetylcholine receptor ligand on neuropathic pain

Fumihiro Saika, Norikazu Kiguchi, Yuka Kobayashi, Shiro Kishioka
Dept. Pharmacol., Wakayama Med Univ
Journal of Pharmacological Sciences 124 (suppl) 184-184, 2014.

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P2-5-2 The examination in a rat fibromyalgia model caused by specific alternation of rhythm in temperature stress (SART)

Takahashi Ikuo, Hikawa Naomi, Morizumi Kousuke, Katayama Seiichi, Atai Hiroshi, Nishi Katsuhide
Mitsubishi Chemical Medience Corporation
Journal of Pharmacological Sciences 124 (suppl) 184-184, 2014.

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P2-5-3 Antinociceptive effect of narcotic analgesics in neuropathic pain state

Takahiro Sumi, Hirokazu Mizoguchi, Chizuko Watanabe, Akihiko Yonezawa, Shinobu Sakurada
Dept. Physiol. Anat. Tohoku Pharmaceut. Univ
Journal of Pharmacological Sciences 124 (suppl) 184-184, 2014.

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P2-5-4 T-type Ca2+ channel inhibiting activity and anti-hyperalgesic effect of SOPHORAE RADIX-derived sophoraflavanone G and its analogues

Fumiko Sekiguchi1, Tomoyo Fujita1, Takahiro Deguchi2, Maki Ichii1, Hiroyuki Nishikawa1, Shigeru Yoshida3, Kazuya Murata2, Hideaki Matsuda2, Tsuyako Ohkubo4, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm, 2Div. Natural Drug Resources, Kinki Univ. Sch. Pharm, 3Dep. Life Sci., Kinki Univ. Sch. Engineer, 4Dep. Physiol. Sci. Mol. Biol., Fukuoka Dent. Coll
Journal of Pharmacological Sciences 124 (suppl) 185-185, 2014.

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P2-5-5 Early-life adversity as a risk factor for aggravation of neuropathic pain in later life

Gaku Sakamoto, Hiroyuki Mizoguchi, Kazuya Fukumoto, Jun Sato
Fut. Environ. Sim. Center, Res. Inst. Environ. Med., Nagoya Univ
Journal of Pharmacological Sciences 124 (suppl) 185-185, 2014.

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P2-5-6 Tacrolimus, a calcineurin inhibitor, potentiates capsaicin-evoked colonic pain in mice

Yuka Terada1, Maho Tsubota1, Fumiko Sekiguchi1, Kyoichi Wada2, Takeshi Kuwahara2, Mitsutaka Takada3, Atsufumi Kawabata1
1Div. Pharmacol. Pathophysiol., Kinki Univ. Sch. Pharm, 2Dept. Pharm., Natl. Cereb. Cardiovasc. Cent, 3Div. Appl. Clin. Pharm., Kinki Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 185-185, 2014.

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P2-5-7 Studies on drug dependence (Rept. 490): Effect of the sigma-1 receptor agonist SA4503 on the oxaliplatin- and paclitaxel-induced allodynia in rats

Aki Masumoto, Tomohisa Mori, Masato Harumiya, Jumpei Oya, Mika Fukase, Masahiro Shibasaki, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 185-185, 2014.

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P2-5-8 Antagonistic effect of angiotensin (1-7) on angiotensin II-induced nociceptive behavior in mice

Wataru Nemoto1, Osamu Nakagawasai1, Fukie Yaoita1, Takeshi Tadano2, Koichi Tan-no1
1Dept. Pharmacol., Tohoku Pharm. Univ, 2Lab. Env. Health Sci. Kanazawa Univ
Journal of Pharmacological Sciences 124 (suppl) 186-186, 2014.

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P2-5-9 C-C chemokine receptor type 5 is an important pathological regulator in the development and maintenance of neuropathic pain

Katsuyuki Matsushita1, Chinami Kojima2, Hidetoshi Tozaki-Saitoh2, Makoto Tsuda2, Sumio Hoka1, Kazuhide Inoue2
1Dept. Anesth. and CCM, Kyushu Univ. Med, 2Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharmaceut. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 186-186, 2014.

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P2-6-1 Repeated stress on ovariectomized mice increase risk taking behaviors via GABAergic dysfunction, which are rescued by 17α-estradiol treatment

Takao Tsukahara1, Masaaki Masuhara1, Takahiro Sonomura3, Haruki Iwai2, Masanori Uemura1, Tomoaki Sato1
1Dept. Applied Pharm., Kagoshima Univ. Sch. Dent, 2Dept. Oral Anat., Kagoshima Univ. Sch. Dent, 3Dept. Anat. 2., Kanazawa med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 186-186, 2014.

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P2-6-2 Effect of curcumin on diazepam-induced disinhibited behaviors in mice

Ken-ichi Tanaka1,2, Satoshi Sakai2, Ai Sakamoto2
1Physiol. Pharmacol., Sch. Health. Social. Serv., Saitama Pre. Univ, 2Dept. Clin. Pharma., Shujitsu Univ. Sch. Pharma
Journal of Pharmacological Sciences 124 (suppl) 186-186, 2014.

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P2-6-3 Possible involvement of autophagy signaling in Li2CO3-induced enhancement of the proliferation of neural progenitor cells derived from the subventricular zone of adult mice

Tatsuo Shiba, Masanori Yoneyama, Masato Koga, Kiyokazu Ogita
Dept. Pharmacol., Setsunan Univ
Journal of Pharmacological Sciences 124 (suppl) 187-187, 2014.

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P2-6-4 Yokukansan increases 5-HT1A receptors and decreases 5-HT2A receptors in prefrontal cortex of socially isolated mice

Toshiyuki Ueki, Akinori Nishi, Kyoji Sekiguchi, Takuji Yamaguchi, Kazushige Mizoguchi, Yasushi Ikarashi, Yoshio Kase
Tsumura Res. Lab., Tsumura & Co
Journal of Pharmacological Sciences 124 (suppl) 187-187, 2014.

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P2-6-5 Behavioral-pharmacological evaluation system in a new social interaction test

Taku Yamaguchi1, Hanako Jingushi1, Ryo Fukumori1, Mitsuhiro Yoshioka2, Tsuneyuki Yamamoto1
1Dept. Pharmacol., Fac. Pharmaceut. Sci., Nagasaki Natl Univ, 2Dept. Neuropharmacol., Hokkaido Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 187-187, 2014.

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P2-6-6 Altered expression of PACAP in the mPFC in depression-like states induced by chronic social defeat stress

Keisuke Hazama1, Atsushi Kasai1,2, Sumiaki Ogawa1, Atsuko Hayata3, Norihito Shintani1, Akemiti Baba4, Hitoshi Hashimoto1,3,5
1Lab. Mol. Neuropharm., Grad. Sch. Pharmaceut. Sci., Osaka Univ, 2Interdisciplinary Program for Biomedical Sciences, Institute for Academic Initiatives, Osaka University, 3Center Child Mental Dev., Unit. Grad. Sch.Child Dev., Osaka Univ, 4Pharmaceut. Sci., Hyogo Univ. of Health Sci, 5iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology
Journal of Pharmacological Sciences 124 (suppl) 187-187, 2014.

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P2-6-7 Gender differences in the serotonergic mechanism underlying emotional regulation of rats

Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yoshiki Yangawa, Yasuhiro Saito, Keiichi Shimamura, Hiroko Togashi
Dept. Pharmacol., Fac. of Pharm. Sci., Health Sci. Univ. of Hokkaido
Journal of Pharmacological Sciences 124 (suppl) 188-188, 2014.

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P2-6-8 Tetrahydrobiopterin (BH4) induces antidepressant-like effects in mice

Takahiro Toda1, Hiroyuki Hasegawa2, Akiko Ohashi2, Noriko Tagawa3, Ikuo Kato3, Yoshihiro Hotta4, Jun Yamada1, Yumi Sugimoto1
1Lab. Pharmacol., Dept. Clin. Pharmacy, YokohamaColl. of Pharmacy, 2Div. Anatomical Science, Dept. Functional Morphology, Nihon Univ. Sch. Med, 3Sept. Med. Biochem., Kobe Pharm. Univ, 4Coll. Pharm. Kinjo Gakuin Univ
Journal of Pharmacological Sciences 124 (suppl) 188-188, 2014.

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P2-6-9 Protective effect of Asiasari radix on the depression like behavior in mice

Keiji Sato1, Kyosuke Uno1, Harue Sasaya1, Yoshiaki Miyamoto1, Shigetoshi Kadota2, Atumi Nitta1
1Deot of Pharm Therapy and Neuropharmacol, Fac of Pharm sci, Grad Sch of Med and Pharm Sci, Univ of Toyama, 2Division of Natural Product Chemistry, Institute of Natural Medicine, Univ of Toyama
Journal of Pharmacological Sciences 124 (suppl) 188-188, 2014.

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P2-6-10 Fluvoxamine improves voluntary activity mediated by serotonin level in amygdala in OVX rats

Yukiko Ishibashi1,2, Tomomi Morikawa3, Takayuki Manabe3, Michio Kimura4, Nobuo Izumo5
1Dept. Biochem., Yokohama Col. Pharm, 2United Grad. Sch. of Child Development., Osaka Univ, 3Div. Gene Exp. Mech., Ins. Comp. Med. Sci., Fujita Health Univ, 4Japan Col. Pharm, 5Dept. Clin. Pharmacol., Yokohama Col. Pharm
Journal of Pharmacological Sciences 124 (suppl) 188-188, 2014.

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P2-7-1 Antipruritic effect of kappa-opioid receptor agonist in mice

Takahiro Niida1,2, Hirokazu Mizoguchi1, Chizuko Watanabe1, Akihiko Yonezawa1, Hiroshi Nagase2, Shinobu Sakurada1
1Dept. Physiol. Anat. Tohoku Pharmaceut. Univ, 2Dept. Med. Chem, IIIS, WPI, Tsukuba Univ
Journal of Pharmacological Sciences 124 (suppl) 189-189, 2014.

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P2-7-2 Effects of nicotine on brain Fos protein expression in the mice

Naofumi Kunisawa, Saki Simizu, Yuto Mizuguchi, Takahiro Okumura, Takahiro Mukai, Midori Ochiai, Yusuke Mizobe, Miyuki Tamura, Yuichi Takakubo, Yoshiko Kawai, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 189-189, 2014.

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P2-7-3 Glycinergic mechanism controled activity of masticatory muscle during sleep

Kazunori Adachi1,2, Shunsuke Hino3, Tetsuo Shimoyama3, Hiroshi Sakagami1
1Div. Pharmacol., Meikai Univ. Sch. Dent, 2Dept. Pharmacol., Nihon Univ. Sch. Dent, 3Oral and maxillofacial Surgery, Saitama Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 189-189, 2014.

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P2-7-4 The effect of anti-HMGB1 antibody on collagenase-induced intracerebral hemorrhage in rats

Katsuyaku Ryu1, Dengli Wang1, Hidenori Wake1, Kiyoshi Teshigawara1, Hideo Takahashi2, Shuji Mori3, Masahiro Nishibori1
1Dept. Pharmacol., Okayama Univ. Sch. Med, 2Department of Pharmacology Kinki University School of Medicine, 3Department of Pharmacy Shujitsu University
Journal of Pharmacological Sciences 124 (suppl) 189-189, 2014.

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P2-7-5 Effect of non-nutritive sweetener intake on brain functions: Behavioral analyses

Mariko Yamamoto, Masayuki Hiramatsu
Dept. Chem. Pharmacol., Fac. Pharm., Meijo Univ
Journal of Pharmacological Sciences 124 (suppl) 190-190, 2014.

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P2-7-6 Effect of non-nutritive sweetener intake on brain functions: Changes in energy homeostasis

Masayuki Hiramatsu, Masashi Itoh
Dept. Chem. Pharmacol., Fac. Pharm., Meijo Univ
Journal of Pharmacological Sciences 124 (suppl) 190-190, 2014.

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P2-7-7 Neuropeptide Y in the dorsal raphe nucleus inhibits expression of maternal behavior in mice

Yoshikage Muroi, Toshiaki Ishii
Dept. Basic Vet., Obihiro Univ
Journal of Pharmacological Sciences 124 (suppl) 190-190, 2014.

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P2-7-8 Effect of HGF and TGF-β on barrier functions in rat brain capillary endothelial cells

Shinsuke Nakagawa1, Narumi Yamada2, Tomonori Takeshita3, Masami Niwa1,4
1Dept. Pharmacol., Nagasaki Univ., Grad. Sch. Biomed. Sci, 2Department of Hepa., Nagasaki Univ., Grad. Sch, 3Dept. Neurosur., Nagasaki Univ., Grad. Sch, 4PharmaCo-Cell
Journal of Pharmacological Sciences 124 (suppl) 190-190, 2014.

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P2-8-1 Effect of exenatide on oxaliplatin-induced peripheral neuropathy

Shunsuke Fujita1, Soichiro Ushio1, Ken Masuguchi2, Nana Ozawa1, Yuko Ono1, Misaki Baba1, Takehiro Kawashiri2, Satohiro Masuda1,2, Ryozo Oishi1,2, Nobuaki Egashira2
1Fac. Sch. Pharm. Sci., Kyushu Univ, 2Dept. Pharmacy, Kyushu Univ. Hosp
Journal of Pharmacological Sciences 124 (suppl) 191-191, 2014.

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P2-8-2 Induced pluripotent stem cells generated from P0-Cre x Z/EG transgenic mice

Akira Eto, Yasuhiro Ogawa, Kazuhiko Oishi
Dept. Pharmacol., Meiji Pharmaceutical Univ
Journal of Pharmacological Sciences 124 (suppl) 191-191, 2014.

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P2-8-3 Metabotropic glutamate receptor type 5 biphasically modulates heat pain behavior in mice

Takayoshi Masuoka1, Makiko Kudo1, Junko Yoshida1, Yuki Takaoka1, Takaharu Ishibashi1,2, Matomo Nishio1
1Dept. Pharmacol., Kanazawa Med Univ. Sch. Med, 2Pharmacol., Kanazawa Med Univ. Sch. Nurs
Journal of Pharmacological Sciences 124 (suppl) 191-191, 2014.

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P2-8-4 Contribution of CAT/MPST to H2S production in peripheral neurons

Ryo Miyamoto, Ken-ichi Otsuguro, Soichiro Yamaguchi, Shigeo Ito
Dept. Pharmacol., Hokkaido Univ. Grad. Sch. Vet. Med
Journal of Pharmacological Sciences 124 (suppl) 191-191, 2014.

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P2-8-5 Effect of aging on the release of endogenous norepinephrine from adrenergic nerves and pain-related behavior in type 2 diabetic model rats

Reiko Ishii-Nozawa, Taira Matsuba, Rika Hagiwara, Megumi Kiyohara, Takuya Satoh, Shiho Suzuki, Ayaka Takasu, Hajime Kagaya
Dept. Clin. Pharmac., Meiji Pharmaceut. Univ
Journal of Pharmacological Sciences 124 (suppl) 192-192, 2014.

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P2-8-6 Effects of raloxifene and tamoxifen on plasma membrane estrogen receptors and catecholamine synthesis and secretion in cultured bovine adrenal medullary cells

Hirohide Inagaki1,2, Yumiko Toyohira1, Keita Takahashi1, Susumu Ueno4, Go Obara3, Masato Tsutsui5, Kojiro Takahashi1, Xiaojia Li1, Toru Hachisuga2, Nobuyuki Yanagihara1
1Dept. Pharmacol., Univ. Occup. & Environ. Hlth., Sch. Med, 2Dept. OB/GYN, Univ. Occup. & Environ. Hlth., Sch. Med, 3Dept. Anesth., Univ. Occup. & Environ. Hith., Sch. Med, 4Dept. Occup. Txicol., Inst. Ecol. Sci., Univ. Occup. & Environ. Hlth, 5Dept. Pharmacol., Grad. Sch. Med., Univ. of the Ryukyus
Journal of Pharmacological Sciences 124 (suppl) 192-192, 2014.

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P2-9-1 Endostatin increases proliferation and migration of rat cardiac fibroblasts

Muneyoshi Okada, Yoko Oba, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 192-192, 2014.

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P2-9-2 Effect of SM-368229, a novel mineralocorticoid receptor antagonist, in volume-overloaded rats with heart failure

Maki Koyama, Eiko Kawakami, Hiroto Akai, Mamoru Ohkita, Yasuo Matsumura
Lab. Pathol. and Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 192-192, 2014.

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P2-9-3 Cardiac vagal control in a knock-in mouse of dilated cardiomyopathy with a troponin mutation

Dong-Yun Zhan1, Cheng-Kun Du1, Tsuyoshi Akiyama1, Sachio Morimoto2, Shuji Shimizu1, Toru Kawada1, Mikiyasu Shirai1
1Natl. Cereb. Cardiovas. Res. Ctr.Inst, 2Fac.Med. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 193-193, 2014.

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P2-9-4 Pravastatin attenuates cardiac dysfunction induced by lysophosphatidylcholine in isolated rat hearts

Li-bing Li
Department of Cardiovascular Surgery, Chinese PLA General Hospital
Journal of Pharmacological Sciences 124 (suppl) 193-193, 2014.

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P2-9-5 Myocardial interstitial serotonin (5-HT) and 5-hydroxyindole acetic acid (5-HIAA) levels during ischemia-reperfusion

Cheng-Kun Du, Dong-Yun Zhan, Tsuyoshi Akiyama, Tadakatsu Inagaki, Mikiyasu Shirai
Dept. of Cardiac Physiol., Natl. Cereb. Cardiovas. Ctr
Journal of Pharmacological Sciences 124 (suppl) 193-193, 2014.

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P2-9-6 Absence of latent TGF-β binding protein-4 (LTBP-4) induces cardiac hypertrophy

Hitomi Otani, Tomoyuki Nakamura
Dept. Pharmacol., Kansai Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 193-193, 2014.

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P2-9-7 Overexpression of the amino-terminal domain of TRPV2 has the beneficial effect for dilated cardiomyopathy mice with mutation of troponin T

Shinya Kamauchi1, Yuko Iwata1, Cheng-Kun Du2, Dong-Yun Zhan2, Sachio Morimoto3, Mikiyasu Shirai2, Shigeo Wakabayashi1
1Dept. Mol. Physiol., N.C.V.C, 2Dept. Cardiac Physiol., N.C.V.C, 3Dept. Clin. Pharmacol., Kyusyu Univ., Grad. Sch. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 194-194, 2014.

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P2-9-8 Canstatin increases matrix metalloproteinases secretion and cyclooxygenase-2 expression in rat cardiac fibroblasts

Naoki Murata, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 194-194, 2014.

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P2-10-1 Oseltamivir inhibits burst pacing-induced atrial fibrillation in the hypertrophy model of rats caused by abdominal aortocaval fistula

Mizuki Nada1, Megumi Aimoto1, Keita Yagi1, Aya Ezawa1, Atsushi Sugiyama2, Akira Takahara1
1Dept. Pharmacol. Ther., Fclt. Pharmaceut. Sci., Toho Univ, 2Dept. Pharmacol., Fclt. Med., Toho Univ
Journal of Pharmacological Sciences 124 (suppl) 194-194, 2014.

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P2-10-2 Assessment of Electrophysiological Profile and Proarrhythmic Effects of E-4031 in the Canine Models

Hiroko Izumi-Nakaseko1, Yuji Nakamura1, Xin Cao1, Naoya Ueda1, Hiroshi Ohara1,2, Yukiko Yamazaki1,2, Kentaro Ando1, Atsushi Sugiyama1
1Dept. Pharmacol., Fclt. Med., Toho Univ, 2Div. of Cardiovasc. Med., Dept. of Internal Med., Toho Univ., Faculty of Med
Journal of Pharmacological Sciences 124 (suppl) 194-194, 2014.

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P2-10-3 In Vivo Electropharmacological Effects of Amantadine Hydrochloride Assessed in the Halothane-Anesthetized Canine Model

Xin Cao1, Yuji Nakamura1, Hiroshi Ohara1,2, Yukiko Yamazaki1,2, Hiroko Izumi-Nakaseko1, Kentaro Ando1, Atsushi Sugiyama1
1Dept. Pharmacol., Fclt. Med., Toho Univ, 2Div. of Cardiovasc. Med., Dept. of Internal Med., Toho Univ., Faculty of Med
Journal of Pharmacological Sciences 124 (suppl) 195-195, 2014.

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P2-10-4 hERG channel facilitation prevents hazardous prolongation of cardiac action potential durations

Kazuharu Furutani, Kunichika Tsumoto, Yoshihisa Kurachi
Dept. Pharmacol., Osaka Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 195-195, 2014.

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P2-10-5 Rapid automated patch clamping using frozen cell stock

Atsushi Ohtsuki1,2, Masato Nishio1, Iyuki Namekata1, Hikaru Tanaka1
1Dept. Pharmacol., Toho Univ. Fclt. Pharmaceut. Sci, 2Nanion Technologies GmbH
Journal of Pharmacological Sciences 124 (suppl) 195-195, 2014.

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P2-10-6 KCNQ1 channel does not form a complex with α1 adrenergic receptor when it is internalized by the receptor activation

Kazuya Kurakami, Ikuo Norota, Yoshinobu Nagasawa, Yutaro Obara, Kuniaki Ishii
Dept. Pharmacol., Yamagata Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 195-195, 2014.

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P2-10-7 The role of ubiquitination in ET-1-dependent endothelin type B receptor trafficking

Koji Terada, Takahiro Horinouchi, Tsunehito Higashi, Nepal Prabha, Mika Horiguchi, Chizuru Hatate, Akimasa Hoshi, Yosuke Mai, Takuya Harada, Soichi Miwa
Dept. Cell. Pharmacol., Hokkaido Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 196-196, 2014.

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P2-10-8 Analysis for the role of CNOT3-mediated mRNA metabolism in cardiac homeostasis

Takashi Suzuki, Keiji Kuba, Teruki Sato, Ayumi Kadowaki, Yumiko Imai
Dept. Biol. Info. & Exp. Ther., Akita Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 196-196, 2014.

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P2-10-9 Increased Up4A-induced contraction in type 2 diabetic renal artery due to activated COX/thromboxane receptor axis

Takayuki Matsumoto, Shun Watanabe, Kumiko Taguchi, Tsuneo Kobayashi
Dept. Physiol. and Morphol., Inst. Med. Chem., Hoshi Univ
Journal of Pharmacological Sciences 124 (suppl) 196-196, 2014.

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P2-11-1 The mechanism of skeletal muscle atrophy induced by iron

Mizuki Imao1,2, Yasumasa Ikeda2, Yuya Horinouchi2, Yuki Izawa-Ishizawa2, Yoshitaka Kihira2, Keisuke Ishizawa1, Koichiro Tsuchiya1, Toshiaki Tamaki2
1Dept. Biochemistry., Tokushima Univ.Sch. Pharmacy, 2Department of Pharmacology, University of Tokushima Graduate School of Health Biosciences
Journal of Pharmacological Sciences 124 (suppl) 196-196, 2014.

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P2-11-2 Metabolic regulation of clathrin heavy chain CHC22

Sakamoto Kazuho1,2, Stephane Camus2, Frances Brodsky2
1Dept. Pharmacol., Fukushima Med. Univ. Sch. Med, 2UCSF
Journal of Pharmacological Sciences 124 (suppl) 197-197, 2014.

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P2-11-3 Regulation of myogenic differentiation by PDZRN3 protein through Wnt signaling

Takeshi Honda, Narumi Nakada, Ryoto Nagai, Makoto Inui
Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 197-197, 2014.

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P2-11-4 Exposure to pressure stimulus affects cell growth and lactate metabolism in cultured human skeletal muscle cells

Kenji Iizuka, Takuji Machida, Masahiko Hirafuji
Dept. of Pharmacol. Sci., School of Pharm. Sci., Health Sci. Uni. of Hokkaido
Journal of Pharmacological Sciences 124 (suppl) 197-197, 2014.

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P2-11-5 Role of SESTD1 in skeletal muscle

Akira Hanashima1, Sumiko Kimura2, Takashi Murayama1
1Dept. Pharmacol., Sch. Med, Juntendo Univ, 2Dept Biol, Grad Sci, Chiba Univ
Journal of Pharmacological Sciences 124 (suppl) 197-197, 2014.

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P2-11-6 Preparation of wrinkle mouse model in a short period of time and evaluation of medicines

Yasushi Yamada, Yasuo Osanai, Emi Fujimoto, Tohru Toyoshi, Takao Ota
Nihon Bioresearch Inc
Journal of Pharmacological Sciences 124 (suppl) 198-198, 2014.

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P2-11-7 Involvement of epidermal histamine in itch-related behavior induced by repeated application of sodium dodecyl sulfate to mouse skin

Yoshihiro Inami1,2, Tsugunobu Andoh1, Atsushi Sasaki1, Yasushi Kuraishi1
1Dept, of Applied Pharmacol., Grad. Sch. of Med. and Pharm. Sci., Univ. of Toyama, 2Fundamental Research Lab., Hoyu Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 198-198, 2014.

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P2-11-8 Role of microRNA on preadipocyte differentiation

Yuka Murata1,2, Koichiro Wada1, Kae Hirata2, Takashi Yamashiro2
1Dept. Pharmacol., Grad. Sch. Dent., Osaka Univ, 2Dept. Orthodontics and Dentofacial Orthop., Grad. Sch. Dent., Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 198-198, 2014.

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P2-11-9 Systemic and local effects of abdominal vibration on high-fat diet-induced obese mice

Yoshiyuki Tanabe1, Maki.T. Saito1, Akihisa Kamataki2, Takashi Sawai2, Koichi Nakayama1
1Dept. Mol. Cell. Pharmacol., Iwate Med. Univ. Sch. Pharm. Sci, 2Dept. Pathol. Iwate Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 198-198, 2014.

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P2-11-10 Expression control mechanism of SLURPs, genes associated with skin diseases

Kazuaki Kose, Yasuhiro Moriwaki, Natsuki Kubo, Tomohiro Ishii, Hidemi Misawa
Dept. Pharmacol, Fac. Pharm, Keio Univ
Journal of Pharmacological Sciences 124 (suppl) 199-199, 2014.

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P2-12-1 KCTD20, an isoform of BTBD10, is a novel Akt activator

Mikiro Nawa, Masaaki Matsuoka
Dept. Pharmacol., Toyko Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 199-199, 2014.

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P2-12-2 Potent inhibitory effects of RGS8 on intracellular calcium responses to vasoactive peptides : importance of the C-terminal part of its RGS domain

Mariko Nishiyama, Sayaka Sumimiya, Sadao Kimura
Dept. of Biochem. and Mol. Pharmacol., Grad. Sch. of Med., Chiba Univ
Journal of Pharmacological Sciences 124 (suppl) 199-199, 2014.

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P2-12-3 Effects of HMG-CoA reductase inhibitors on P2Y1 receptor-mediated IL-8 release

Shouta Arai, Masa-aki Ito, Isao Matsuoka
Lab. Pharmacol., Fact. Pharm, Takasaki Univ. of Health and Welfare
Journal of Pharmacological Sciences 124 (suppl) 199-199, 2014.

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P2-12-4 Flurbiprofen ameliorated endoplasmic reticulum stress by interacting with aldehyde dehydrogenase

Toru Hosoi1, Rie Yamaguchi1, Kikuko Noji1, Takaaki Kayano2, Kohei Mori2, Koichiro Ozawa1
1Depart. Pharmacotherapy, Grad. Sch. Biomed. Health Sci., Hiroshima Univ, 2Depart. Pharmacotherapy, Grad. Sch. Biomed. Health Sci., Hiroshima Univ
Journal of Pharmacological Sciences 124 (suppl) 200-200, 2014.

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P2-12-5 Phosphorylation of Ca2+/calmodulin-dependent protein kinase Iβ2 in cortical neurons

Ai Saito, Yuri Ikeda-Matsuo, Shun Watanabe, Takashi Iwai, Mitsuo Tanabe, Yasuhito Naito
Dept. Pharmcol., Sch. Pharmac. Sci., Kitasato Univ
Journal of Pharmacological Sciences 124 (suppl) 200-200, 2014.

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P2-12-6 Analysis of Ca2+ dynamics in the endoplasmic reticulum and mitochondria in pancreatic β-cells

Tsubasa Nishikawa, Junji Suzuki, Kazunori Kanemaru, Masamitsu Iino
Dept. Pharmacol., Grad.Sch.Med., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 200-200, 2014.

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P2-12-7 The regulatory mechanism underlying the enhanced expression of BK channel by testosterone

Regis Azizieh1, Akinori Ohno1, Susumu Ohya2, Yoshiaki Suzuki1, Hisao Yamamura1, Yuji Imaizumi1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ, 2Dept. Pharmacol., Kyoto Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 200-200, 2014.

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P2-12-8 Endothelial cell dysfunction via hypoxia macrophage-derived exosomes

Mayuko Oka1, Masaki Nishiyama2, Yasukatsu Izumi2, Masayuki Shiota2, Masako Tanaka2, Katsuyuki Miura3, Hiroshi Iwao2
1Grad. Sch. Life Enviro. Sci., Kyoto Pref. Univ, 2Dep. Pharm., Osaka City Univ, 3Dep. Appl. Pharmacol. ther., Osaka City Univ
Journal of Pharmacological Sciences 124 (suppl) 201-201, 2014.

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P2-12-9 Analysis of behavior of cyclophilin D in mitochondrial permeability transition

Keita Kageyama1, Yasuo Shinohara2, Takenori Yamamoto2, Naoshi Yamazaki1, Yoshiharu Takiguchi1
1Dept.Clin.Pharmacol., Inst.Health Biosci., Tokushima Univ. Grd.Sch, 2Div.Prot.Expression, Inst.Genome Res., Tokushima Univ
Journal of Pharmacological Sciences 124 (suppl) 201-201, 2014.

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P2-12-10 Effect of organotin compound on mitochondrial function

Miki Asanagi1,2, Shigeru Yamada1, Hiroshi Itagaki2, Yuko Sekino1, Yasunari Kanda1
1Div. Pharmacol., NIHS, 2Div. Mater. Sci. Chem. Eng., Fac. Eng., Yokohama Natl Univ
Journal of Pharmacological Sciences 124 (suppl) 201-201, 2014.

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P2-13-1 Microsomal prostaglandin E synthase-1 facilitates angiogenesis and lung metastasis formation in prostate cancer cells

Ryo Takahashi1,2, Hideki Amano1, Takefumi Satoh2, Masatsugu Iwamura2, Masataka Majima1
1Department of Molecular Pharmacology, Graduate School of Medicine, Kitasato University, 2Department of Urology, Graduate School of Medicine, Kitasato University
Journal of Pharmacological Sciences 124 (suppl) 201-201, 2014.

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P2-13-2 Effects of all-trans retinoic acid on gene expression and proliferation of promyelocytic leukemia cells

Takeaki Nitto, Mizuki Takahashi, Katsuya Honta, Kenta Tanaka, Daichi Nagashima, Kouhei Sawaki
Lab. Pharmacother., Yokohama Coll. Pharm
Journal of Pharmacological Sciences 124 (suppl) 202-202, 2014.

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P2-13-3 LPS/TLR4 signaling induces imatinib-resistance in Chronic myeloid leukemia-model cells

Fujiko Tsukahara, Yoshiro Maru
Dept. Pharmacol., Tokyo Women's Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 202-202, 2014.

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P2-13-4 Identification of extracellular HSP72 binding proteins

Masako Kawaguchi1, Masako Tanaka1, Masayuki Shiota1, Yasukatsu Izumi1, Katsuyuki Miura2, Hiroshi Iwao1
1Dept. Parmacol., Osaka City Univ. Grad. Sch. Med, 2Appl. Pharmacol. Ther., Osaka City Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 202-202, 2014.

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P2-13-5 Effect of propofol on hydrogen peroxide-induced apoptosis in alveolar epithelial cells

Hiroko Matsumoto1, Liguo Wei2, Reiri Takeuchi1, Hidenori Yamaguchi2, Koh Shibutani2
1Dept. Pharmacol., Nihon Univ. Sch. Dent. Matsudo, 2Dept. Anesthe., Nihon Univ. Sch. Dent. Matsudo
Journal of Pharmacological Sciences 124 (suppl) 202-202, 2014.

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P2-13-6 Comparison of anti-oxidative and cell protective effects between piceatannol and resveratrol

Ryusuke Hosoda1, Atushi Kuno1,2, Yusuke Hori1, Rio Sebori1, Hiroki Hamada3, Yoshiyuki Horio1
1Dept. Pharmacol., Sapporo Med. Univ. Sch. Med, 2Dept. 2nd.Int.Med., Sch.of Med., Sapparo Med.Univ, 3Dept. Life. Sci., Okayama Sci. Univ. Sch. Sci
Journal of Pharmacological Sciences 124 (suppl) 203-203, 2014.

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P2-13-7 S-allyl-L-cysteine inhibits calpain activity through interaction with its Ca2+-binding site

Yasuhiro Kosuge, Toru Imai, Kumiko Ishige, Yoshihisa Ito
Lab. Pharmacol., Sch. Pharma., Nihon Univ
Journal of Pharmacological Sciences 124 (suppl) 203-203, 2014.

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P2-14-1 The anti-oxidative and the anti-inflammatory effects of Linagliptin in Hemodialysis Patients with Diabetes

Hitomi Hasegawa1, Yuya Nakamura1,2, Mayumi Tsuji1, Masahiro Inagaki3, Hiromichi Gotoh2, Yoshikazu Goto2, Katsuji Oguchi1
1Dept. Pharmacol., Showa Univ. Sch. Med, 2Saiyu Soka Hospital, 3Dept. Chem. Col. Arts & Sci. Showa Univ
Journal of Pharmacological Sciences 124 (suppl) 203-203, 2014.

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P2-14-2 Inhibitory effects of fucoidan on the IL-1β induced inflammation in SW982 human synovial sarcoma cells

Masayuki Arai, Mayumi Tsuji, Youko Ao, Manami Inagaki, Ai Nakajima, Yasuyuki Kondo, Katsuji Oguchi
Dept. Pharmacol., Showa Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 203-203, 2014.

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P2-14-3 Isolation of a L-rhamnose-binding lectin from the globiferous pedicellariae of the toxopneustid sea urchin, Toxopneustes pileolus

Hitomi Sakai1, Kozue Edo2, Hiroyuki Hase1, Hideyuki Nakagawa1, Mitsuko Shinohara3, Kiyoshi Ohura3
1Dept. of Environmental Symbiosis, Inst. of Socio-Arts and Sci., Univ. of Tokushima Grad. Sch, 2Dept. of Nutritional Sci., Junior College Division, Shikoku Univ, 3Dept. of Pharmacol., Osaka Dental Univ
Journal of Pharmacological Sciences 124 (suppl) 204-204, 2014.

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P2-14-4 Suppressive effect of LAT1-specific inhibitor on the activation of human T cells

Keitaro Hayashi1, Promsuk Jutabha1, Hitoshi Endou2, Naohiko Anzai1
1Dept. Pharmacol. and Toxicol., Dokkyo med. Univ. Sch. Med, 2J-Pharma Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 204-204, 2014.

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P2-14-5 Role of cyclooxygenase-2 in remodeling of draining lymph nodes during acute inflammation

Michiko Kawamura1, Yoshiteru Harada2
1Dept. Pharmacol., Kitasato Univ. Sch. Med, 2Dept. Mediator & Signal Transduction Pharmacol., Kitasato Univ. Graduate Sch. Medical Sciences
Journal of Pharmacological Sciences 124 (suppl) 204-204, 2014.

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P2-14-6 Molecular mechanism of lipid nanoparticle-induced neuroinflammatory response in mouse brain

Ying-mei Lu, Jun-wei Huang, Chong Xu, Han-min Sun, Shan-shan Lin
Zhejiang University City College
Journal of Pharmacological Sciences 124 (suppl) 204-204, 2014.

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P2-14-7 Prolonged febrile seizures increase seizure susceptibility in adulthood via a cascade increase of IL-1β and CB1R signaling

Yang-Shun Tang, Bo Feng, Yun-Jian Dai, Bin Chen, Deng-Chang Wu, Xiang-Nan Zhang, Ceng-Lin Xu, Zhong Chen
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 205-205, 2014.

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P2-14-8 In vitro establishment of the IL-6 inflammatory model based on the mouse embryonic stem cells derived liver-like tissue

Tong Li, Lu Li, Ke Jin, Danyan Zhu, Yijia Lou
Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 205-205, 2014.

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P2-15-1 Ameliorative effect of yokukansan on the emotional abnormality in stress-maladaptive mice

Hiroko Miyagishi, Minoru Tsuji, Kazuya Miyagawa, Atsumi Saito, Daisuke Ishii, Kotaro Takeda, Taro Imai, Hiroshi Takeda
Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare
Journal of Pharmacological Sciences 124 (suppl) 205-205, 2014.

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P2-15-2 Yokukansan, a traditional Japanese herbal medicine, alleviates the anxiety-like behavior induced by prenatal restraint stress in mice

Atsumi Saito, Kazuya Miyagawa, Hiroko Miyagishi, Daisuke Ishii, Kotaro Takeda, Taro Imai, Minoru Tsuji, Hiroshi Takeda
Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare
Journal of Pharmacological Sciences 124 (suppl) 205-205, 2014.

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P2-15-3 Study of evaluation method of natural killer cell activity in mice with flow cytometry

Takumi Yamazawa, Shinichi Ozato, Kousuke Morizumi, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Corporation
Journal of Pharmacological Sciences 124 (suppl) 206-206, 2014.

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P2-15-4 Restraint stress strongly disturbs the mouse circadian clock systems

Yu Tahara1, Takuya Shiraishi1, Yosuke Kikuchi1, Nobuaki Onishi1, Shun-ya Yamada2, Atsushi Haraguchi1, Daisuke Kuriki1, Shigenobu Shibata1
1Sch. of Adv. Sci. and Engi., Waseda Univ, 2Dept. Chem., Sch. of Sci., Tokyo univ
Journal of Pharmacological Sciences 124 (suppl) 206-206, 2014.

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P2-15-5 Circadian rhythm of inflammatory reaction and chrono-pharmacological treatment to the ulcerative colitis in mice

Yosuke Kikuchi, Yu Tahara, Takuya Shiraishi, Shigenobu Shibata
Sch. of Adv. Sci. and Engi., Waseda Univ
Journal of Pharmacological Sciences 124 (suppl) 206-206, 2014.

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P2-15-6 Circadian Rhythm of a Neuroprotective System Regulated by microRNA in Mice

Chisato Kinoshita, Nobuko Matsumura, Kazue Kikuchi-Utsumi, Toshio Nakaki
Dept. Pharmacol., Teikyo Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 206-206, 2014.

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P2-15-7 Establishment of circadian rhythm sleep disorder model in mice

Kyoko Matsuzawa, Masami Katou, Takahito Imaizumi, Tohru Toyoshi
Nihon Bioresearch Inc
Journal of Pharmacological Sciences 124 (suppl) 207-207, 2014.

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P3-1-1 A protein kinase C-Y knockout Parkinsonian model: Involvement of Pak-Interacting Exchange Factor-β

Toshihiko Shirafuji1,2, Takehiko Ueyama2, Ken-ichi Yoshino2, Naoko Adachi2, Hideyuki Takahashi2, Naoki Hiramatsu3, Yukio Ago3, Toshio Matsuda3, Norio Sakai1, Naoaki Saito2
1Dept. Molecul and Pharmacol Neurosci., Hiroshima Univ, 2Molecular. Pharmacol., Biosignal Res. Ctr., Kobe Univ, 3Lab. Medicinal Pharmacol. Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 207-207, 2014.

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P3-1-2 Coexpression of H3R decrease NET uptake activity and membrane expression in CHO cells stably express NET

Xuefang Wen1, Chiharu Sowaga1, Kazumi Ohyama2, Ayako Jinzenji1,3, Takuya Miyawaki3, Norio Sogawa1
1Dept. Dent. Pharmacol., Okayama Univ. Grad. Sch. Med. Dent. Pharm, 2RI Res. Cent., Okayama Univ. Sch. Dent, 3Dental Anesthesiology and Special Care Dentistry, Okayama Univ. Grad. Sch. Med. Dent. Pharm
Journal of Pharmacological Sciences 124 (suppl) 207-207, 2014.

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P3-1-3 Ocular albinism 1 is the G protein-coupled receptor and mediates depressor and bradycardic responses to DOPA in the nucleus tractus solitarii

Masukawa Daiki1, Hiroshi Miyamoto2, Fumio Nakamura1, Moemi Kaneda1, Nobuhiko Fukuda1, Saki Naito1, Itaru Endo2, Yoshio Goshima1
1Dept. Mol. Pharmacol and Neurobiol., Yokohama City Univ. Sch. Med, 2Dept. Gastroenterol. Surg., Yokohama City Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 207-207, 2014.

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P3-1-4 OA1 mediates L-DOPA induced Ca2+ response in cultured hippocampal neurons

Fumio Nakamura1, Moemi Kaneda1,2, Yoshio Goshima1
1Dept Mol Pharmacol, Sch Med, Yokohama City Univ, 2Lab. Cell.Neurobiol., Sch. Life Sci., Tokyo Univ. Pharm. & Life Sci
Journal of Pharmacological Sciences 124 (suppl) 208-208, 2014.

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P3-1-5 Distribution of L-DOPA receptor, ocular albinism 1 (OA-1)-immunoreactivities in central and peripheral tissues

Nobuhiko Fukuda, Saki Naito, Daiki Masukawa, Moemi Kaneda, Fumio Nakamura, Yoshio Goshima
Dept. Mol. Pharmacol and Neurobiol., Yokohama City Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 208-208, 2014.

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P3-1-6 Experience-dependent regulation of synaptic functions in mature mouse barrel cortex

Jun Kubota, Kazunori Kanemaru, Yohei Okubo, Masamitsu Iino
Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo
Journal of Pharmacological Sciences 124 (suppl) 208-208, 2014.

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P3-1-7 Modulation of noradrenaline transporter function by red wine polyphenol

Yumiko Toyohira1, Go Obara2, Hirohide Inagaki1, Keita Takahashi1, Xiaojia Li1, Kojirou Takahashi1, Nobuyuki Yanagihara1
1Dept. Pharmacol., Univ. Occup. & Environ. Hlth., Sch. Med, 2Dept. Anesth., Univ. Occup. & Environ, Hlth., Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 208-208, 2014.

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P3-2-1 Ependymal cells of the mouse brain express urate transporter 1 (URAT1)

Naoko Tomioka1, Makiko Nakamura2, Yoshiharu Deguchi3, Kimiyoshi Ichida2, Takayuki Morisaki4, Makoto Hosoyamada1
1Dept. Human Physiol. Pathol., Fac. Pharma-Sciences, Teikyo Univ, 2Dept. Pathophysiol, Tokyo Univ. of Pharmacy Life Sciences, 3Dept. Drug Disposition Pharmacokinetics, Fac. Pharma-Sciences, Teikyo Univ, 4Dept. Biosci. Genetics, NCVC Res. Inst
Journal of Pharmacological Sciences 124 (suppl) 209-209, 2014.

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P3-2-2 Involvement of MRP1 in noradrenaline-induced astrocyte-mediated neuroprotecion

Yasuhiro Yoshioka, Eriko Ikuta, Hisatsugu Kadoi, Akiko Yamamuro, Yuki Ishimaru, Sadaaki Maeda
Dept. Pharmacotherap., Faculty Pharmaceut. Sci., Setsunan Univ
Journal of Pharmacological Sciences 124 (suppl) 209-209, 2014.

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P3-2-3 Involvement of the proteasome in TNF-α and IFN-Y-mediated down-regulation of connexin43 in spinal astrocytes

Fangfang Zhang1, Norimitsu Morioka1, Tomoya Kitamura2, Kazue Nakashima-Hisaoka1, Yoshihiro Nakata1
1Dept. Pharmacol., Hiroshima Univ Grad. Sch. Biomed & Health Sci, 2Sch. Pharm., Hiroshima Univ. Biomed & Health Sci
Journal of Pharmacological Sciences 124 (suppl) 209-209, 2014.

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P3-2-4 Nicotinic acetylcholine receptors modulate TNF-α-induced MMP-9 release from brain pericytes

Ikuya Kimura, Shinya Dohgu, Fuyuko Takata, Junichi Matsumoto, Takashi Machida, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharm. Care Helth Sci., Fac. Pharm. Sci., Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 209-209, 2014.

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P3-2-5 In vivo fluorescence imaging of extracellular ATP in cerebral cortex

Kaname Satoh1, Hiroshi Sekiya1, Kenji Takikawa2, Hirokazu Sakamoto2, Tetsuro Ariyoshi2, Shigeyuki Namiki2, Kenji Tanaka3, Kenzo Hirose2, Masamitsu Iino1
1Dept. of Pharmacol., Grad. Sch. of Med., Univ. of Tokyo, 2Dept. of Neurobiol., Grad. Sch. of Med., Univ. of Tokyo, 3Neuropsych, Keio Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 210-210, 2014.

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P3-2-6 Transcriptional regulation of microglial motility by IRF8

Tsuyoshi Matsuda1, Hidetoshi Tozaki-Saitoh1, Takahiro Masuda1, Nao Nishimoto1, Tomohiko Tamura2, Shinichi Kohsaka3, Makoto Tsuda1, Kazuhide Inoue1
1Dept. Mol. Sys. Pharmacol., Grad. Sch. Pharmceut. Sci., Kyushu Univ, 2Dept. Immunol. Grad. Sch. Med., Yokohama City Univ, 3Dept. Neurochemistry, National Institute of Neuroscience
Journal of Pharmacological Sciences 124 (suppl) 210-210, 2014.

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P3-2-7 The involvement of β-adrenergic receptors in the regulation of c-jun N-terminal kinase and CCL2 production in TNF-stimulated spinal astrocytes

Norimitsu Morioka, Hiromi Abe, Ryosuke Araki, Fang Fang Zhang, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakata
Dept. Pharmacol., Hiroshima Univ. Grad. Sch. Biomed. Health Sci
Journal of Pharmacological Sciences 124 (suppl) 210-210, 2014.

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P3-2-8 Production of GM-CSF and up-regulation of GM-CSF receptor α participate in microglial survival by TLR4 activation

Mayumi Kamigaki1, Izumi Hide1, Yuhki Yanase2, Takahiro Seki1, Toshihiko Shirafuzi1, Michihiro Hide2, Norio Sakai1
1Dept. of Mol. and Pharmacol. Neurosci, Inst of Biomed & Health Sci, Hiroshima Univ, 2Dept. of Dermatol, Inst of Biomed & Health Sci, Hiroshima Univ
Journal of Pharmacological Sciences 124 (suppl) 210-210, 2014.

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P3-2-9 Modulation of microglial function by TLR4-mediated adenosine A2a receptor activation

Izumi Hide1, Mayumi Kamigaki1, Yuhki Yanase2, Takahiro Seki1, Shigeru Tanaka1, Toshihiko Shirafuji1, Michihiro Hide2, Norio Sakai1
1Dept. Mol. Pharmacol. Neurosci., Inst. Biomed. Health Sci., Hiroshima Univ, 2Dept. Dermatol., Inst. Biomed. Health Sci., Hiroshima Univ
Journal of Pharmacological Sciences 124 (suppl) 211-211, 2014.

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P3-2-10 Possible role of astrocyte activation in diabetes-induced hippocampal dysfunction in mice

Akihiro Yamada, Noboru Inoue, Kazuhiko Kume, Masahiro Ohsawa
Dept. Phamacol, Nagoya City Univ
Journal of Pharmacological Sciences 124 (suppl) 211-211, 2014.

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P3-3-1 Peripheral stress impairs the formation of inhibitory avoidance memory via vagal afferents

Emi Tomikawa, Hiroshi Nomura, Norio Matsuki
Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo
Journal of Pharmacological Sciences 124 (suppl) 211-211, 2014.

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P3-3-2 Excessive expression of ezrin in the hippocampus is induced by intrastriatal injection of 6-hydroxydopamine

Masatoshi Inden1, Yosuke Matsumoto2, Shinji Asano2
1Lab. Med. Therap. Mol. Therap., Gifu Pharm. Univ, 2Dept. Mol. Physiol., College Pharm. Sci., Ritsumeikan Univ
Journal of Pharmacological Sciences 124 (suppl) 211-211, 2014.

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P3-3-3 CNB-001, a synthesized pyrazole derivative of curcumin, promotes NMDA receptor- and CaMKII-dependent long-term potentiation

Tatsuhiro Akaishi1, Pamela Maher2, David Schubert2, Kazuho Abe1
1Lab. Pharmacol., Fac. Pharm., Musashino Univ, 2Cell. Neurobiol. Lab., Salk Inst
Journal of Pharmacological Sciences 124 (suppl) 212-212, 2014.

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P3-3-4 Modafinil affects the neural activity during attention in healthy adults

Yumiko Ikeda1, Takuya Funayama2, Amane Tateno3, Hidehiko Takahashi4, Yoshiro Okubo3, Hidenori Suzuki1
1Dept Pharmacol, Grad Sch Med, Nippon Med Sch, 2Dept Anesthesiol Clin Physiol, Grad Sch, Tokyo Med Dent Univ, 3Dept Neuropsych, Grad Sch Med, Nippon Med Sch, 4Dept Psych, Grad Sch Med, Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 212-212, 2014.

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P3-3-5 The role of glial glutamate transporter (GLAST) in cognitive functions in mice

Yukihiro Noda1, Shoh Hasegawa1, Masayuki Taniguchi1, Hirotake Hida1, Akihiro Mouri1, Masako Kunimoto2, Kiyofumi Yamada3, Norio Ozaki2, Kohichi Tanaka4, Toshitaka Nabeshima5
1Div Clin Sci & Neuropsychopharm, Meijo Univ Sch Pharm, 2Dept Psychiatry, Nagoya Univ Sch Med, 3Dept Neuropsychopham & Hosp Pharm, Nagoya Univ Sch Med, 4Dept Mol Neurosci Sch Biomed Sci, Tokyo Med Dent Univ, 5Dept Rerio Phamaceut care & Sci, Meijo Univ Sch Pharm
Journal of Pharmacological Sciences 124 (suppl) 212-212, 2014.

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P3-3-6 Betaine suppresses Hsc70 expression in parallel with GAT2 after water-immersion restraint stress

Masayuki Hiramatsu1, Ryo Ueda1, Yuki Sakakibara1, Kasumi Nishioka1, Ryoji Kojima2
1Dept. Chem. Pharmacol., Fac. Pharm., Meijo Univ, 2Dept. Anal. Pharmacol., Fac. Pharm., Meijo Univ
Journal of Pharmacological Sciences 124 (suppl) 212-212, 2014.

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P3-3-7 Effects of bupropion on reward processing in healthy individuals: a pharmacological fMRI study

Takuya Funayama1, Yumiko Ikeda2, Amane Tateno3, Hidehiko Takahashi4, Yoshiro Okubo3, Haruhisa Fukayama1, Hidenori Suzuki2
1Anesthesiol Clin Physiol, Grad Sch, Tokyo Med Dent Univ, 2Dept Pharmacol, Grad Sch of Med, Nippon Med Sch, 3Dept Neuropsychiatry, Grad Sch of Med, Nippon Med Sch, 4Dept Neuropsychiatry, Grad Sch of Med, Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 213-213, 2014.

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P3-3-8 Biphasic effect of microRNA-132 on object recognition memory in Alzheimer's disease mouse models

Takashi Kubota, Yutaka Kirino
Lab. Neurobiophysics, Kagawa Sch. Pharm. Sci., Tokushima Bunri Univ
Journal of Pharmacological Sciences 124 (suppl) 213-213, 2014.

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P3-3-9 Melatonin treatment attenuated the aberrancies in hippocampal serine/ threonine kinases signaling in autism animal model

Ling-juan Hong1, Rui-Ting Zhang1, Yun Tian1, Pei-Jiang Mao1,2, Rui Wang1, Sen Long1,3, Feng Han1
1Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, 2Zhejiang Research Institute of Traditional Chinese Medicine, 3Department of Pharmacy, Hangzhou No. 7 People's Hospital
Journal of Pharmacological Sciences 124 (suppl) 213-213, 2014.

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P3-4-1 Effect of clonidine in the 5-tiral inhibitory avoidance test using juvenile spontaneously hypertensive rats

Kazuaki Kawaura, Hirohiko Hikichi, Jun-ichi Karasawa, Shigeyuki Chaki
Discov.Pharmacol.1, Mol.Func.Pharmacol.Labs., Taisho Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 213-213, 2014.

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P3-4-2 Analysis of effects on mouse brain stimulated by repetitive Transcranial Magnetic Stimulation

Tetsurou Ikeda1, Nobuyuki Nukina2
1Dept. Clinical Immunology., Tokyo Univ. Institute of Med, 2Riken BSI SNP team, Saitama prefecture
Journal of Pharmacological Sciences 124 (suppl) 214-214, 2014.

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P3-4-3 Effect of antipsychotics on telomere length in the hippocampus

Kazuya Toriumi, Mitsuhiro Miyashita, Tomoe Ichikawa, Izumi Nohara, Mayumi Arai, Nanako Obata, Masanari Itokawa
Proj. Schizophr. Affect. Disord. Res., Dept. Psychiatry Behav. Sci., Tokyo Metropol. Inst. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 214-214, 2014.

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P3-4-4 Overcrowding rearing in the nighttime produces anxiolytic- and antidepressant-like effects in juvenile mice

Tatsunori Tanaka1, Yukio Ago1, Emina Imoto1, Mari Kitamoto1, Yuki Ota1, Kazuhiro Takuma1, Toshio Matsuda1,2
1Lab. of Medicinal Pharmacol., Grad. Sch. of Pharmaceut. Sci. Osaka Univ, 2Unit-Grad. Sch. of Child Dev., Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 214-214, 2014.

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P3-4-5 The effects of valproate on the abnormal behaviors in diacylglycerol kinase β knockout mice

Mitsue Ishisaka1, Kazuhiro Tsuruma1, Masamitsu Shimazawa1, Yasuhito Shirai2, Hideaki Hara1
1Mol. Pharmacol., Dept. Biofunct. Eval., Gifu Pharmaceut. Univ, 2Applied Chemistry in Bioscience, Graduate School of Agriculture
Journal of Pharmacological Sciences 124 (suppl) 214-214, 2014.

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P3-4-6 Cerebellar D3 receptor-mediated alleviation of extrapyramidal disorder by AD-6048, a primary metabolite of blonanserin

Saki Shimizu, Ayaka Tatara, Maho Sato, Tomone Sugiuchi, Satoshi Miyoshi, Saki Andatsu, Tomoya Kizu, Yukihiro Ohno
Lab. Pharmacol., Osaka Univ. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 215-215, 2014.

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P3-4-7 The role of glial glutamate transporter (GLAST) in psychobehavioral abnormalities following repeated administration of phencyclidine

Kentaro Mori1, Yurie Matsumoto1, Hirotake Hida1, Akihiro Mouri1, Kiyofumi Yamada2, Norio Ozaki3, Kohichi Tanaka4, Toshitaka Nabeshima5, Yukihiro Noda1
1Div Clin Sci & Neuropsychopharmcol, Meijo Univ Grad Sch Pharm, 2Dept Neuropsychophamcol & Hosp Pharm, Nagoya Univ Grad Sch Med, 3Dept Psychiatry, Nagoya Univ Grad Sch Med, 4Dept Mol Neurosci Sch Biomed Sci, Tokyo Med Dent Univ, 5Dept Region Pharmaceutical Care Sci, Meijo Univ Fac Pharm
Journal of Pharmacological Sciences 124 (suppl) 215-215, 2014.

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P3-4-8 An early decrease of ripple precedes seizure onset in mesial temporal lobe epilepsy

Ceng-Lin Xu, Zhong Chen
Department of Pharmacology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China and Zhejiang Province Key Laboratory of Neurobiology, College of Pharmaceutical Sciences, School of Medicine, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 215-215, 2014.

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P3-5-1 The innate immune signaling plays an essential role in stress-induced emotional changes

Shiho Kitaoka1,4, Nie Xiang1,4, Kohei Tanaka1, Atsubumi Ogawa1, Yuki Imoto2, Eri Segi-Nichida3, Shuh Narumiya1,4, Tomoyuki Furuyashiki1,4
1MIC, Kyoto Univ. Sch. Med, 2Department of Physiological Chemistry, Kyoto Univ. Graduate School of Pharmaceutical Sciences, 3Department of Systems Bioscience for Drug Discovery, Kyoto University Grad Sch Pharm Sci, 4JST-CREST
Journal of Pharmacological Sciences 124 (suppl) 215-215, 2014.

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P3-5-2 5-HT1A receptor stimulation mediates effects of an mGlu2/3 receptor antagonist and ketamine in the novelty-suppressed feeding test

Kenichi Fukumoto, Michihiko Iijima, Shigeyuki Chaki
Discov. Pharmacol. 1. Mol. Func. Pharmacol. Labs., Taisho Pharmaceutical Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 216-216, 2014.

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P3-5-3 The effect of forced swimming on the level of FGF20 in the hippocampus and immobility time in the forced swimming test

Toru Oda, Kumatoshi Ishihara
Laboratory of Neuropharmacol., Faculty of Pharm. Sci., Hiroshima Int. Univ
Journal of Pharmacological Sciences 124 (suppl) 216-216, 2014.

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P3-5-4 Mouse brain areas that are probably involved in ambulation promoted by bupropion, an antidepressant and a smoking cessation agent. Examinations using c-Fos immunocytochemistry

Toyoshi Umezu
Cent. Environm. Measur. Anal.. Natl. Inst.Environm. Stud
Journal of Pharmacological Sciences 124 (suppl) 216-216, 2014.

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P3-5-5 Intracerebroventricular administration of LPA induced anxiety-like behavior in mice via LPA receptors

Mai Tsukagoshi1,2, Misa Yamada1, Tomio Hashimoto1, Jun-Ichiro Oka2, Akiyoshi Saitoh1, Mitsuhiko Yamada1
1Dept. of Neuropsychopharmacology, National Inst. of Mental Health, National Center of Neurology and Psychiatry, 2Lab. of Pharmacol., Fac. of Pharm. Sci., Tokyo Univ. of Sci
Journal of Pharmacological Sciences 124 (suppl) 216-216, 2014.

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P3-5-6 Dopamine D2 receptor modulates anxiety-related behavior following repeated swim stress in juvenile mice

Shuichi Hiroyama, Ayane Sakaguchi, Masahito Horiuchi, Tetsuji Itoh
Drug Safety Evaluation, Drug Develop. Res. Lab., Shionogi & Co., Ltd
Journal of Pharmacological Sciences 124 (suppl) 217-217, 2014.

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P3-5-7 LPS induced depressive-like behavior is mediated by α1 adrenoceptor activation dependent GluR1 internalization in mouse medial prefrontal cortex and ventral tegmental area

Miyu Sekio, Kenjiro Seki
Dept. Pharmacol., School of Pharmaceutical Science, Ohu University
Journal of Pharmacological Sciences 124 (suppl) 217-217, 2014.

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P3-5-8 Effect of chronic fluoxetine on spine morphology of granule cells in the dentate gyrus: 3-dimensional reconstruction study using FIB/SEM

Yosuke Kitahara1, Keisuke Ohta2, Takahide Shuto1, Mahomi Kuroiwa1, Naoki Sotogaku1, Hiroshi Hasuo3, Akinobu Togo4, Kei-ichiro Nakamura2, Akinori Nishi1
1Dept. Pharmacol., Kurume Univ. Sch. Med, 2Dept. Anatomy., Kurume Univ. Sch. Med, 3Dept. Physiol., Kurume Univ. Sch. Med, 4Center Unit of Electorn microscopy., Kurume Univ
Journal of Pharmacological Sciences 124 (suppl) 217-217, 2014.

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P3-5-9 Functional changes of the medial prefrontal cortex induced by repeated social defeat stress in mice

Ryota Shinohara1, Aliza Ehrlich1,2, Kentaro Yokogawa1, Shuh Narumiya1,2, Tomoyuki Furuyashiki1,2
1MIC, Kyoto Univ. Grad. Sch. Med, 2CREST, JST
Journal of Pharmacological Sciences 124 (suppl) 217-217, 2014.

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P3-5-10 Dietary histidine is important for histaminergic nervous system

Takeo Yoshikawa1, Tetsuro Shibakusa2, Mayu Sugita2, Attayeb Mohsen1, Fumito Naganuma1, Kazuhiko Yanai1
1Dept. Pharmacol., Tohoku Univ. Grad. Sch. Med, 2Ajinomoto CO. Inc
Journal of Pharmacological Sciences 124 (suppl) 218-218, 2014.

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P3-6-1 Exogenous agmatine inhibits methamphetamine-induced stereotypy and hyperlocomotion in mice

Junichi Kitanaka1, Nobue Kitanaka1, F.Scott Hall2, George.R. Uhl2, Koh-ichi Tanaka3, Nobuyoshi Nishiyama3, Tomohiro Tatsuta4, Motohiko Takemura1
1Dept. Pharmacol., Hyogo Col. Med, 2Mol. Neurobiol., NIDA-IRP, 3Div. Pharmacol., Dept., Pharm., Sch. Pharm., Hyogo Univ. Health Sci, 4Ibogawa Hosp
Journal of Pharmacological Sciences 124 (suppl) 218-218, 2014.

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P3-6-2 A single administration of morphine impairs Morris water maze task in mice

Nobue Kitanaka1, Junichi Kitanaka1, Akira Koizumi1, Minako Sumikawa1, Soichiro Otaki1, Hirotoshi Kuroiwa1, Mei Fujii1, Koh-ichi Tanaka2, Nobuyoshi Nishiyama2, Motohiko Takemura1
1Dept. Pharmacol., Hyogo Col. Med, 2Div. Pharmacol., Dept. Pharm., Sch. Pharm., Hyogo Univ. Health Sci
Journal of Pharmacological Sciences 124 (suppl) 218-218, 2014.

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P3-6-3 Studies on drug dependence (Rept.488) : CB2 receptor were involved in the suppression of the rewarding effect of methamphetamine (METH) by lipopolysaccharides (LPS)

Yuiko Ikekubo, Masahiro Shibasaki, Kouji Andou, Yutori Ishikawa, Ami Otokozawa, Kenji Okabe, Shono Kikuta, Akane Higashi, Tomohisa Mori, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 218-218, 2014.

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P3-6-4 Cyclophilin D is implicated in the cognitive deficits and serotonergic neurotoxicity induced by 3,4-methylenedio xymethamphetamine (MDMA) in mice

Akihiro Mouri1, Yukihiro Noda1, Shigeomi Shimizu2,3, Yoshihide Tsujimoto2, Toshitaka Nabeshima4
1Div. Clin Sci & Neuropsychopharm, Meijo Univ. Sch. Pharm, 2Lab. Mol. Gene., Dept. Med. Gene., Osaka Univ, Med, 3Dept. Pathol. Cell. Biol., Med. Res. Inst., Tokyo Med and Dent Univ, 4Dept. Region. Pharm. Care. & Sci, Meijo Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 219-219, 2014.

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P3-6-5 Effects of corticosterone on the ethanol withdrawal-induced cognitive impairment in ethanol dependent mice

Hideaki Kato, Minoru Tsuji, Kazuya Miyagawa, Kotaro Takeda, Hiroshi Takeda
Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare
Journal of Pharmacological Sciences 124 (suppl) 219-219, 2014.

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P3-6-6 Implication of type 1 inositol 1, 4, 5-trisphosphate receptors (IP3Rs-1) in mouse nucleus accumbens on ethanol-induced rewarding effect

Kazuhiro Kurokawa, Koji Mizuno, Seitaro Ohkuma
Dept. Pharmacol., Kawasaki Med. Univ
Journal of Pharmacological Sciences 124 (suppl) 219-219, 2014.

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P3-6-7 Studies on drug dependence (Rept.491) : Effect of caffeine on morphine-induced hyperlocomotion

Yoshiyuki Iwase, Masahiro Shibasaki, Yuya Udagawa, Akane Higashi, Tomohisa Mori, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm. Pharmaceut. Sci
Journal of Pharmacological Sciences 124 (suppl) 219-219, 2014.

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P3-6-8 Studies on drug dependence (Rept.489): Change in ethanol-metabolizing system by chronic treatment with ethanol in the mouse brain

Yutori Ishikawa, Masahiro Shibasaki, Koji Ando, Yuiko Ikekubo, Ami Otokozawa, Kenji Okabe, Shono Kikuta, Akane Higashi, Tomohisa Mori, Tsutomu Suzuki
Dept. Toxicol., Hoshi Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 220-220, 2014.

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P3-6-9 Effects of antidepressants on methamphetamine-induced conditioned place preference in ddY mice

Kumatoshi Ishihara, Mai Takita
Lab. Neuropharmacol., Fac. Pharm. Sci., Hiroshima Intl. Univ
Journal of Pharmacological Sciences 124 (suppl) 220-220, 2014.

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P3-7-1 Omentin prevents early inflammatory responses in aorta of high fat-fed mice

Kyosuke Kazama, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Vet. Med., Kitasato Univ. sch
Journal of Pharmacological Sciences 124 (suppl) 220-220, 2014.

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P3-7-2 Significance of the vascular concentration of angiotensin II receptor blockers on the lowering mechanism of blood pressure in spontaneously hypertensive rats

Shinji Takai1, Denan Jin1, Hiroshi Sakonjo2, Takayuki Takubo3, Toyofumi Nakanishi3
1Dept. Pharmacol. Osaka Med. Coll, 2Shiga Res. Nissei BILIS, 3Dept. Clin. Lab. Med. Osaka Med. Coll
Journal of Pharmacological Sciences 124 (suppl) 220-220, 2014.

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P3-7-3 Phenotype analyses of GAD67-GFP Knock-In Mouse

Kozue Takano1, Junichi Yatabe1,2,3, Midori Yatabe1,3, Tsuyoshi Watanabe2,3, Yuchio Yanagawa4, Atsuo Fukuda5, Junko Kimura1
1Dept. Pharmacol., Fukushima Med. Univ. Sch. Med, 2Dept. CKD Initiatives, Fukushima Med. Univ. Sch. Med, 3Dept. Nephrol., Hypertens., Diabetol., Endo. and Metabo., Fukushima Med. Univ. Sch. Med, 4Gunma Univ. Graduate Sch. Med, 5Dept. Neurophysiol., Hamamatsu Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 221-221, 2014.

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P3-7-4 Caveolin-1 inhibits doxorubicin-induced apoptosis through suppressing ERK and p38 activation in H9c2 cells

Maiko Kamato, Akira Takaguri, Kazuo Ichihara, Kumi Satoh
Dept. Pharmacol., Hokkaido Pharmacuetical Uni
Journal of Pharmacological Sciences 124 (suppl) 221-221, 2014.

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P3-7-5 Study of Evaluation System for Angiogenesis in a Mouse Model of Hindlimb Ischemia

Shinichiro Tsunesumi, Takashi Tashiro, Naoyuki Hironaka, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Pharmacology Department, Nonclinical Research Center, Drug Development Service Segment, Mitsubishi Chemical Medience Corporation
Journal of Pharmacological Sciences 124 (suppl) 221-221, 2014.

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P3-7-6 Cellular origin of human aortic valve calcification may be CD34-negative mesenchymal stem-like cells

Kazuhiko Seya1, Anan Nomura1,2, Zaiqiang Yu1,2, Kazuyuki Daitoku2, Shigeru Motomura1, Manabu Murakami1, Ikuo Fukuda2, Ken-Ichi Furukawa1
1Dept. Pharmacol., Hirosaki Univ. Grad. Sch. Med, 2Dept. Thorac. Cardiovasc. Surg., Hirosaki Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 221-221, 2014.

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P3-7-7 Probucol ameliorates dysfunction of retinal circulation in diabetic rats

Kentaro Higashi, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm
Journal of Pharmacological Sciences 124 (suppl) 222-222, 2014.

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P3-7-8 BMP4 enhances the uptake of oxLDL into peritoneal macrophages by increasing CD36 scavenger receptors

Yuki Kanaoka, Mitsuhisa Koga, Naoka Kubo, Yuma Ohkido, Keita Sugiyama, Kaoru Ohishi, Atsushi Yamauchi, Yasufumi Kataoka
Dept. Pharm. Care and Health Sci., Fac. Pharm. Sci., Fukuoka Univ
Journal of Pharmacological Sciences 124 (suppl) 222-222, 2014.

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P3-7-9 Comparative effect of angiotensin II type I receptor blockers on serum uric acid in hypertensive patients with type 2 diabetes mellitus: a retrospective observational study

Yayoi Nishida1, Yasuo Takahashi1, Kotoe Tezuka1, Satoshi Asai2
1Clin. Trials Res. Center, Nihon Univ. Sch. Med, 2Dev. Pharmacol. Nihon univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 222-222, 2014.

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P3-8-1 Upregulation of chemokine expression by Streptococcus mutans bearing collagen-binding protein in cultured brain endothelial cells

Yuji Matsumoto1, Kazuya Hokamura1, Ryota Nomura2, Kazuhiko Nakano2, Takashi Ooshima2, Kazuo Umemura1
1Dep. Pharmacol., Hamamatsu Univ. Sch. Med, 2Dep. Pediatric Dent., Osaka Univ. Grad. Sch. Dent
Journal of Pharmacological Sciences 124 (suppl) 222-222, 2014.

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P3-8-2 Tissue-type plasminogen activator induced vascular endothelial growth factor in cultured endothelial cells on ischemia

Yasuhiro Suzuki1, Nobuo Nagai2, Kasumi Yamakawa1, Kazuya Hokamura1, Kazuo Umemura1
1Dept. Pharmacol., Hamamatsu Univ. Sch. Med, 2Dept. Animal Biosci. Nagahama Inst. Bio-Sci. Tech
Journal of Pharmacological Sciences 124 (suppl) 223-223, 2014.

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P3-8-3 Role of mono- and di-phosphorylation of myosin light chain in thrombin-induced endothelial barrier disruption

Mayumi Hirano, Katsuya Hirano
Dept. Mol. Cardiol., Grad. Sch. Med. Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 223-223, 2014.

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P3-8-4 Nitrosonifedipine ameliorates the progression of renal disease associated with endothelial dysfunction independently of eNOS

Keisuke Ishizawa1, Yuki Ishizawa2, Noriko Yamano2, Asami Nuno1, Masaki Imanishi2, Takumi Sakurada2, Yoshitaka Kihira2, Yasumasa Ikeda2, Koichiro Tsuchiya1, Toshiaki Tamaki2
1Dept. Med. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch, 2Dept. Pharmacol., Inst. Health Biosciences, Univ. Tokushima Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 223-223, 2014.

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P3-8-5 Effects of teneligliptin on the function of spontaneously released NO from endothelium in popliteal artery of OLETF rat

Junko Kajikuri, Takeo Itoh
Dept. Pharmacol., Nagoya City Univ. Grad. Sch. Med. Sci
Journal of Pharmacological Sciences 124 (suppl) 223-223, 2014.

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P3-8-6 Hydrophobic statins enhance the zoledronate-induced damage of endothelial cells

Masamichi Tajima, Hiroshi Sakagami
Div.Pharmacol., Dept.Diagnostic and Therapeutic Sciences, Meikai Univ. Sch.Dent
Journal of Pharmacological Sciences 124 (suppl) 224-224, 2014.

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P3-8-7 Metabolism of drug in rat thoracic aortic endothelial cells

Eiichi Sakurai1, Yukari Ueda1, Eiko Sakurai2
1Dept. Pharmaceutics, Tokushima Bunri Univ, 2Faculty of Pharmacy, Iwaki Meisei University
Journal of Pharmacological Sciences 124 (suppl) 224-224, 2014.

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P3-8-8 Promotion of vascular endothelial cell migration and tube formation by SEK-1005

Hiroki Sakai1, Miya Nakashima1, Hiroo Iwata2, Makoto Inui1
1Dept. Pharmacol., Yamaguchi Univ. Grad. Sch. Med, 2Dept. Reparative Materials, Inst. Front. Med. Sci., Kyoto Univ
Journal of Pharmacological Sciences 124 (suppl) 224-224, 2014.

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P3-8-9 The impaired VEGF function at the earliest stages of retinal vascular development induces abnormal vascular patterning in mouse retina

Akane Morita, Tsutomu Nakahara, Asami Mori, Kenji Sakamoto, Kunio Ishii
Dept. Mol. Pharmacol., Kitasato Univ. Sch. Pharm. Sci
Journal of Pharmacological Sciences 124 (suppl) 224-224, 2014.

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P3-9-1 Effect of calcium channel blocker on mouse renal interstitial fibrosis

Kazuki Nakamura, Masahiro Shinohara, Naho Takahashi, Shigeyoshi Honma, Makoto Yoshida
Dept. Pathophysiol., Fac. Pharmacy, Takasaki University of Health and welfare
Journal of Pharmacological Sciences 124 (suppl) 225-225, 2014.

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P3-9-2 Renoprotective mechanisms of ezetimibe in SHRSP.Z-Lepr(fa)/IzmDmcr rats

Naohiko Kobayashi1, Yasuhiko Ueno1, Yasuko Mamada1, Keiko Fukuda1, Hisato Hirata2, Yoshifumi Machida2, Noriko Suzuki3, Fumie Yokotsuka3, Kyoko Tabei3, Machiko Sakata3, Toshihiko Ishimitsu1
1Dept, of Cordiol. and Nephrol., Dokkyo Med. Univ. Sch. of Med, 2Laboratory Animal Research Center, Dokkyo Medical University School of Medicine, 3Clinical Research Center, Dokkyo Medical University School of Medicine
Journal of Pharmacological Sciences 124 (suppl) 225-225, 2014.

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P3-9-3 DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy

Yuichiro Higashimoto1, Yusuke Kaida1, Takanori Matsui1, Kei Fukami1, Seiya Okuda1, Sho-ichi Yamagishi1, Masayoshi Takeuchi2, Hiroyoshi Inoue3
1Kurume Univ. Sch. of Med, 2Kanazawa Medical University, 3Keio Univ. Sch. of Med
Journal of Pharmacological Sciences 124 (suppl) 225-225, 2014.

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P3-9-4 Effects of high salt diet on daily BP and RSNA, and circadian rhythm in freely moving conscious rats

Yoshihide Fujisawa1, Daisuke Nakano2, Hirofumi Hitomi2, Hiroyuki Kobori2, Akira Nishiyama2
1Life Science Research Center, 2Department of Pharmacology, Faculty of Medicine, Kagawa University
Journal of Pharmacological Sciences 124 (suppl) 225-225, 2014.

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P3-9-5 Novel biomarker analysis in radiocontrast-induced nephropathy rats

Takahiro Sugiura, Yasushi Hirasawa, Koji Iwata, Takahito Imaizumi, Yukiko Kawasaki, Tohru Toyoshi
Nihon Bioresearch Inc
Journal of Pharmacological Sciences 124 (suppl) 226-226, 2014.

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P3-9-6 Cyclic stretch on glomerular endothelial cells, a new in vitro model for glomerular hypertension

Yasuyuki Irie1, Makio Saeki2, Yukiko Kondo1, Naoko Matushita1, Eiichi Taira1
1Dept. Pharmacol., Iwate Medical Univ. Sch. Med, 2Dept. Pharmacol., Osaka Univ. Sch. Den
Journal of Pharmacological Sciences 124 (suppl) 226-226, 2014.

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P3-9-7 Sex differences in ischemia/reperfusion-induced acute kidney injury are dependent on the degradation of noradrenalin by monoamine oxidase

Ryosuke Tanaka1, Maki Yazawa1, Yuri Morikawa1, Hidenobu Tsutsui1,2, Mamoru Ohkita1, Tokihito Yukimura2, Yasuo Matsumura1
1Lab. Pathol. and Mol. Pharmacol., Osaka Univ. Pharmaceut. Sci, 2Lab. Clin. Pharmacol., Fac. Pharm., Osaka Ohtani Univ
Journal of Pharmacological Sciences 124 (suppl) 226-226, 2014.

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P3-9-8 Functional inhibition of NCX2 causes natriuresis and hypercalciuria

Yusuke Gotoh1, Satomi Kita1, Makoto Fujii1, Ichiro Horie1, Yuji Arai2, Shinichi Uchida3, Takahiro Iwamoto1
1Dept. Pharmacol., Facul. Med., Fukuoka Univ, 2Dept. Biosci. and Genetics, NCVC, 3Dept. Nphrol., Tokyo Med. and Dental Univ
Journal of Pharmacological Sciences 124 (suppl) 226-226, 2014.

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P3-10-1 Effects of BIRB796 on LPS-induced airway inflammation in cigarette smoke-exposed mice

Genki Kimura1, Keitaro Ueda1, Takashi Masuko1, Tadashi Kusama1, Kazuhiro Ito2, Yasuo Kizawa1
1Dept. Physiol. & Anat, Nihon Univ. Sch. Pharm, 2NHLI, Imperial Coll., Dov
Journal of Pharmacological Sciences 124 (suppl) 227-227, 2014.

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P3-10-2 Up-regulation of RhoA protein by interleukin-17A in cultured human bronchial smooth muscle

Yoshihiko Chiba1, Gen Tanoue1, Kazuki Shimizu1, Rena Suto1, Wataru Suto1, Shunta Danno1, Takahumi Nakabaru1, Mayumi Matsumoto2, Yasuna Kato2, Keiko Ando2, Hiroyasu Sakai2, Minoru Narita2, Motohiko Hanazaki3, Hiroshi Katayama3
1Dept. Biol., Hoshi Univ. Sch. Pharm, 2Dept. Pharmacol., Hoshi Univ. Sch. Pharm, 3Dept. of Anesthesiol. and Intensive Care Med., Kawasaki Med. Sch
Journal of Pharmacological Sciences 124 (suppl) 227-227, 2014.

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P3-10-3 Continuous administration of olmesartan (RNH6270) attenuates lung expression of inflammatory factor(s) with reduced mortality but no-amelioration of pulmonary hypertension in monocrotaline-treated rats

Leo Tsugaruishi1, Maki. T. Saito1, Manami Suzuki1, Miku Kanno1, Yoshiyuki Tanabe1, Akihisa Kamataki2, Takashi Sawai2, Koichi Nakayama1
1Dept. Mol. Cell. Pharmacol., Iwate Med. Univ. Sch. Pharm, 2Dept. Pathol., Iwate Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 227-227, 2014.

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P3-10-4 A new COPD model -participation of p38 pathway-

Hiroyuki Amano1,2, Kazuya Murata3, Hirofumi Matsunaga4, Kensuke Tanaka1,2, Takeshi Kobayashi1,2, Junji Ishida3, Akiyoshi Fukamizu3, Sadao Kimura1, Koichiro Tatsumi2, Yoshitoshi Kasuya1
1Dept. Biochem. and Mol. Pharmacol., Chiba Univ. Med, 2Dept. of Respirol., Chiba Univ. Med, 3Life Sci center of TARA, Tsukuba Univ, 4Ube Industries Ltd
Journal of Pharmacological Sciences 124 (suppl) 227-227, 2014.

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P3-10-5 Intratracheal administration of ET receptor antagonists attenuates pulmonary inflammation in LPS-induced acute lung injury

Tetsuo Fujita1,2, Kensuke Tanaka1,2, Koichiro Tatsumi2, Sadao Kimura1, Yoshitoshi Kasuya1
1Dep. Biochem.and Mol. Pharmacol., Chiba Univ. Med, 2Dep. Respirol., Univ. Med
Journal of Pharmacological Sciences 124 (suppl) 228-228, 2014.

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P3-11-1 Effect of tachykinin NK3 receptor agonist, senktide on the release of peptide YY from guinea-pig distal colon

Shu-ichi Kojima1, Atsushi Tohei2, Naohiko Anzai1
1Dept. Pharmacol & Toxicol., Dokkyo Med. Univ. Sch. Med, 2Lab. Exp. Animal Sci. Nippon Vet., & Life Sci. Univ
Journal of Pharmacological Sciences 124 (suppl) 228-228, 2014.

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P3-11-2 Protective effect of SKL-2001, a novel agonist of the Wnt/β-catenin pathway, on epithelial tissue injury of intestine of mice

Wakana Ohashi, Takahiro Imaizumi, Takuya Sakamoto, Michinori Takashina, Yuichi Hattori
Dept. of Mol. Med. Pharmacol., Graduate sch. of Med. and Pharm., Univ. of Toyama
Journal of Pharmacological Sciences 124 (suppl) 228-228, 2014.

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P3-11-3 Altered immunolocalization of Osp94, a hypertonic stress sensitive molecular chaperone, in the jejunum of mice exposed to water-immersion restraint stress

Tomoaki Okuda, Yuki Horikawa, Yusuke Sueyasu, Ryoji Kojima
Lab. Anal. Pharmacol., Fac. Pharm., Meijo Univ
Journal of Pharmacological Sciences 124 (suppl) 228-228, 2014.

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P3-11-4 Nicotine suppresses the development of colitis-associated cancer through the inhibition of IL-6/Stat3 pathway in mice

Shusaku Hayashi1, Takayuki Hamada1, Yoko Ishii2, Masakiyo Sasahara2, Makoto Kadowaki1
1Div. Gastrointestinal Pathophysiol., Inst. Natural Med., Univ. Toyama, 2Dept. Pathology, Univ. Toyama
Journal of Pharmacological Sciences 124 (suppl) 229-229, 2014.

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P3-11-5 Glucocorticoid secretion via P2Y1 receptors in human-derived adrenocortical cells

Haruhisa Nishi
Dept. Pharmacol., Jikei Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 229-229, 2014.

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P3-11-6 Investigation of an exercise-performance evaluation system using a running wheel metabolic chamber

Shinichi Ozato, Seiichi Katayama, Hiroshi Atai, Katsuhide Nishi
Pharmacology Department, Nonclinical Research Center, Drug Development Servuce Segment, Mitsubishi Chemical Medience Corporation
Journal of Pharmacological Sciences 124 (suppl) 229-229, 2014.

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P3-11-7 PDZ protein NHERF3 (PDZK1) negatively regulates liver-specific butyrate transporter, OAT7

Toshiyuki Fukutomi1, Toru Kimura1, Naohiko Anzai2, Hiroyuki Sakurai1
1Dept. Pharmacol., Kyorin Univ. Sch. Med, 2Dept. Pharmacol., Dokkyo Med. Univ. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 229-229, 2014.

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P3-11-8 Localization of GPRC6A, the receptor involved in glucose homeostasis

Higashi Sen1, Akiko Mizokami2, Tomoko Ohsumi1, Masato Hirata2, Hiroshi Takeuchi1
1Div. Appl. Pharmacol., Kyushu Dental Univ, 2Lab. Mol. Cell. Biochem., Fac. Dental Sci., Kyushu Univ
Journal of Pharmacological Sciences 124 (suppl) 230-230, 2014.

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P3-11-9 Cytochrome P450 mRNA, protein expression and genetic polymorphism in the small intestine of Japanese Patients

Momoko Kawakami1,2, Sachiko Takenoshita2, Yuko Takeba2, Yuki Ohta2, Naoki Matsumoto2, Shinichi Kobayashi2
1Division of Clinical Pharmacology, Department of Pharmacology, Showa University School of Medicine, 2Department of Pharmacology, St.Marianna University of Medicine, Department of Pharmacogenomics
Journal of Pharmacological Sciences 124 (suppl) 230-230, 2014.

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P3-11-10 Anti-diabetic and anti-obesity effects of KY-226, a novel PTP1B inhibitor, in male mice

Yuma Ito1, Masaki Fukui1, Masahiro Kubo1,2, Tatsuya Kitao1, Mamoru Kanda1, Hiroaki Shirahase1
1Resarch Laboratories, Kyoto Pharmaceutical Industries, Ltd, 2Lab. Mol. Pharmacol., Kanazawa Univ. Grad. Sch
Journal of Pharmacological Sciences 124 (suppl) 230-230, 2014.

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P3-12-1 The effects of the RANK-like peptide on murine rheumatoid arthritis model

Genki Kato1, Yasuhiro Shimizu2, Yasutaka Sugamori1, Mariko Takahashi1, Yukihiko Tamura1, Takashi Ono2, Keiichi Ohya1, Kazuhiro Aoki1
1Dept. Bio-Matrix (Pharmacol.), Tokyo Med&Dent Univ, 2Dept Orofacial Development & Function (Orthodontic Science), Tokyo Med&Dent Univ
Journal of Pharmacological Sciences 124 (suppl) 230-230, 2014.

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P3-12-2 Effects of thiazolidinedione, antidiabetic drug, on bone metabolism in rat

Junkichi Kanda1, Nobuo Izumo2, Yoshiko Kobayashi3, Taketoshi Shimakura4, Noriaki Yamamoto4, Kenta Imai1, Kenji Onodera5, Hiroyuki Wakabayashi1
1Dept. Clin. Pharmacother., Niigata Univ. Pharm. Appli. Life. Sci, 2Dept. Clin. Pharmacol., Yokohama Col. Pharm, 3Dept. Rad. Sci., Yokohama Col. Pharm, 4Niigata Bone Sci. Inst, 5Dept. Clin. Pharmaco. & Pharm. Epilep. Hosp. BETHEL
Journal of Pharmacological Sciences 124 (suppl) 231-231, 2014.

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P3-12-3 Effect of Hachimi-jio-gan on osteopenia induced by OVX mice

Masahito Kim1, Hiroyoshi Ogawa1, Ayumi Fujikawa1, Yukiko Ishibashi2, Kazuki Terada1, Toru Iizuka3
1Dept.Clinic pharmco., Yokohama Colle. Pharm, 2Yokohama Colle. Pharm, 3Yokohama Colle. Pharm
Journal of Pharmacological Sciences 124 (suppl) 231-231, 2014.

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P3-12-4 Effect of MU-314 on bone resorption induced by DEX

Yoshiko Kobayashi1, Takuro Yoda2, Seiji Niimoto2, Yukiko Ishibashi3, Ryo Fukuyama4, Yasushi Kodama5, Yoshitaka Oishi6, Koji Chiba2, Mitsugu Fujita4, Nobuo Izumo2
1Dept.Radi., Yokohama Colle. Pharm, 2Yokohama Colle. Pharm, 3Yokohama Colle. Pharm, 4Lab. Pharmacol., Pharm. Sci., Hiroshima Int. Univ, 5Lab. Clinicopahol. Therap., Pharm. Sci., Hiroshima Int. Univ, 6Sch. Pharm. Sci., Doshisya Women's Col. of Lib. Arts
Journal of Pharmacological Sciences 124 (suppl) 231-231, 2014.

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P3-12-5 Effect of sphingosine 1 phosphate on osteoclast differentiation

Hitoshi Amano1, Kakei Ryu2, Shinichi Iwai3, Jyunichi Kikuta4, Masaru Ishii4, katsuji Oguchi2
1Dept.Pharmacol., Showa Univ. Sch. Dent, 2Dept.Pharmacol., Showa Univ. Sch. Med, 3Dept. Health and Reg. Sch.Pharm, 4Dept. Immunol. and Cell Biol. Graduate Sch Med. Osaka Univ
Journal of Pharmacological Sciences 124 (suppl) 231-231, 2014.

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P3-12-6 Quercetin inhibits osteoclastogenesis via membrane-type estrogen receptor GPR30 and Akt

Masaaki Masuhara, Takao Tsukahara, Tomoaki Sato
Dept. Appl. Pharmacol., Grad. Sch. Med. Dent. Sci., Kagoshima Univ
Journal of Pharmacological Sciences 124 (suppl) 232-232, 2014.

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P3-12-7 Cobalt protoporphyrin prevents osteoclastogenesis via blocking of IkB phosphorylation

Yuka Yashima1,2, Kuniaki Okamoto1, Eiko Sakai1, Kazuhisa Nishishita1, Takayuki Tsukuba1
1Dept. Oral Pathopharmacol., Grad. Sch. Biomed. Sci., Nagasaki Univ, 2Sch. Dent., Nagasaki Univ
Journal of Pharmacological Sciences 124 (suppl) 232-232, 2014.

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P3-12-8 Chemical constituent of Sanguisorba officinalis inhibits osteoclastogenesis

Eiko Sakai1, Mayumi Iwatake1, Yutaka Fukuma1, Kazuhisa Nishishita1, Kuniaki Okamoto1, Takashi Tanaka2, Takayuki Tsukuba1
1Div. Oral Pathopharmacol., Dept. Development. Reconstruct. Med., Nagasaki Univ. Grad. Sch. Biomed. Sci, 2Div. Natural Product Chemistry, Dept Molecular Medical Sciences, Nagasaki Univ. Grad. Sch. Biomed. Sci
Journal of Pharmacological Sciences 124 (suppl) 232-232, 2014.

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P3-12-9 Nicorandil suppresses reduction of bone mineral density in Dahl salt-sensitive hypertensive rats

Yoshihito Tashiro, Kenji Yogo, Kenichi Serizawa, Koichi Endo
Product Research Dept
Journal of Pharmacological Sciences 124 (suppl) 232-232, 2014.

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P3-12-10 Effects of a Chinese herbal formula Tongbiling(TBL)-II for rheumatoid arthritis on matrix metalloproteinase (MMP) expression in an animal model

Yuta Kobayashi1, Xiaoyan Shen2, Songhua Li3
1Dept. Fundament. Nurse., Fac. Med., Shimane Univ, 2Lab. Pharmacol. Toxicol., Sch. Pharmaceut. Sci., Sun Yat-sen Univ, 3Medical Corporation Soujikai
Journal of Pharmacological Sciences 124 (suppl) 233-233, 2014.

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P3-13-1 Rictor/mTORC2 involved in Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells

Bei Zheng, Leilei Tang, Yujie Huang, Danyan Zhu
Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 233-233, 2014.

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P3-13-2 Critically important role of Junctophilin-3, 4 for neurogenesis from mouse embryonic stem cells

Zong-fu Pan1, Bi-de Zhao2, Hao Liu3, Jia-nan Wu3, Yi-jia Lou1
1Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences Zhejiang University, 2Ba de-nian medical class, College of Chu Kechen Honors Zhejiang University, 3Undergraduate students in Research Training Project at Zhejiang University, College of Pharmaceutical Sciences Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 233-233, 2014.

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P3-13-3 Protein nitrosylation promote cardiomyocyte differentiation of mouse embryonic stem cell

Bowen Wu, Hao Yu, Ying Chen, Kejie Huang, Yijia Lou
Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmacutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 233-233, 2014.

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P3-13-4 PPARβ facilitates the differentiation of ES cells into insulin-producing cells by pdx-1 upregulation

Lu Li, Tong Li, Yuyu Zhang, Danyan Zhu, Yijia Lou
Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University
Journal of Pharmacological Sciences 124 (suppl) 234-234, 2014.

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P3-13-5 Study of immunomodulatory effects in human mesenchymal stem cells

Mitsutoshi Satoh1, Takayuki Ohki2, Tomoe Kubo2, Yoji Sato3, Satoshi Muto2
1Dept. Toxicol. & Pharmacol., Phar. Sci., Toho Univ, 2Dept. Dis. Anal., Phar. Sci., Toho Univ, 3Div Cell. & Gene Ther. Prod., NIHS
Journal of Pharmacological Sciences 124 (suppl) 234-234, 2014.

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P3-13-6 S1PR3 is a novel target for breast cancer stem cells

Naoya Hirata1, Shigeru Yamada1, Takuji Shoda2, Masaaki Kurihara2, Yuko Sekino1, Yasunari Kanda1
1Div. Pharmacol., NIHS, 2Div. Organic Chem., NIHS
Journal of Pharmacological Sciences 124 (suppl) 234-234, 2014.

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P3-14-1 The establishment of a noninvasive metabolic syndrome model using an extremely small size minipig

Yasukatsu Izumi1, Takehiro Yamaguchi2, Hiroaki Kawaguchi3, Masashi Tawa4, Masayuki Shiota1, Mayuko Oka1, Akihide Tanimoto5, Katsuyuki Miura6, Hiroshi Iwao1
1Dept. Pharmacol., Osaka City Univ. Med. Sch, 2Dept. Cardiovasc Med., Osaka City Univ. Med. Sch, 3Dept. Histopathol., Kagoshima Univ. Med. Sci, 4Dept. Pharmacol., Shiga Univ. Med. Sci, 5Dep. Mol Cell Pathol., Kagoshima Univ. Grad. Sch. Med. Dent. Sci, 6Applied Pharmacol Ther
Journal of Pharmacological Sciences 124 (suppl) 234-234, 2014.

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P3-14-2 Acetic acid-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of bladder pain

Emi Morita1, Ryoji Mizumachi1, Naoyuki Hironaka1, Takashi Yokawa2, Asami Masuda2, Seiichi Katayama1, Hiroshi Atai1, Katsuhide Nishi1
1Pharmacology Department Nonclinical Research Center Drug Development Service Segment Mitsubishi Chemical Medience Corporation, 2BioView, Inc
Journal of Pharmacological Sciences 124 (suppl) 235-235, 2014.

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P3-14-3 Is the Nagase Analubuminemic Rat (NAR) a suitable AD/HD animal model?

Kosuke Hakamada, Takanobu Yamamoto
Lab.Neurophysiol., Dept.Psychol., Tezukayama Univ
Journal of Pharmacological Sciences 124 (suppl) 235-235, 2014.

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P3-14-4 Evaluation of validity in Shati KO mouse as an animal model for AD/HD

Junko Tanaka1, Kazuya Toriumi1,2, Hiroyuki Watanabe1, Natsumi Kachi1, Akihiro Mouri1,3,6, Takenao Koseki1, Atsumi Nitta4,6, Takayoshi Mamiya1,6, Toshitaka Nabeshima5,6, Masayuki Hiramatsu1,6
1Dept. Chem. Pharmacol., Fac. Pharm. Meijo Univ, 2Proj. Schizophr. Affect. Disord. Res., Dept. Psychiat. Behav. Sci. Tokyo Metropolitan Inst. Med. Sci, 3Div. Clin. Sci. and Neuropsychopharmacol. Fac. Pharm., Meijo Univ, 4Dept. Pharm. Ther. Neuropharmacol. Grad. Sch. Med. Pharm. Sci., Toyama Univ, 5Dept. Region. Pharmaceutical Care Sci. Fac. Pharm., Meijo Univ, 6Japan. Drug Org. Appropriate Use Res
Journal of Pharmacological Sciences 124 (suppl) 235-235, 2014.

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P3-14-5 A spontaneous infertility rat and the sterile mechanism

Minoru Watanabe1,2, Naoki Matsumoto2, Yuko Takeba2, Shiari Nozawa3, Sachiko Takenoshita2, Yuki Ohta2, Toshio Kumai4, Masami Tanaka5
1Inst. Animal Exp., St Marianna Univ. Grad. Sch. Med, 2Dept. Pharmacol., St Marianna Univ. Sch. Med, 3Dept. Urology, St Marianna Univ. Sch. Med, 4Dept. Pharmacogenomics, St. Marianna Univ. Grad. Sch. Med, 5Dept. of Nutrition, Junior College Div., The Univ. of Aizu
Journal of Pharmacological Sciences 124 (suppl) 235-235, 2014.

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P3-14-6 Effects of bezafibrate on high fat and high cholesterol (HFHC) diet-induced murine nonalcoholic steatohepatitis (NASH) model

Toshinori Moritani, Takashi Shimosato, Daisuke Saji, Noriko Minobe, Kagari Kimura, Shoko Kosugi, Hitomi Matsuda, Takeshi Iidaka, Akihiro Ishimoto, Ayahito Kimura, Hiroshi Sakonjo
NISSEI BILIS Co., Ltd., Shiga Laboratory
Journal of Pharmacological Sciences 124 (suppl) 236-236, 2014.

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P3-14-7 Assessment of learning ability, hippocampal neurotransmitters, and effects of repeatedly-administered antidementia drugs in PS2APP mice

Hiroyasu Murasawa, Akiko Nakatani-Pawlak, Tomomi Ogawa, Mie Nakamura, Tohru Toyoshi, Takao Ota
Nihon Bioresearch Inc
Journal of Pharmacological Sciences 124 (suppl) 236-236, 2014.

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P3-14-8 Assessment of symptoms peripheral to dementia and effects of repeatedly-administered antidementia drugs in PS2APP mice

Mie Makamura, Akiko Nakatani-Pawlak, Hiroyasu Murasawa, Tomomi Ogawa, Tohru Toyoshi, Takao Ota
Nihon Bioresearch Inc
Journal of Pharmacological Sciences 124 (suppl) 236-236, 2014.

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P3-15-1 Role of IL-19 in T cell-mediated immune responses

Yasu-Taka Azuma, Yukiko Matsuo, Hidemitsu Nakajima, Tadayoshi Takeuchi
Lab. of Vet. Pharmacol., Division of Vet. Sci., Grad. Sch. Life Env. Sci., Osaka Prefecture Univ
Journal of Pharmacological Sciences 124 (suppl) 236-236, 2014.

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P3-15-2 Effects of ascorbic acid and α-tocopherol on nonalcoholic steatohepatitis in rats

Yukiko Kawasaki, Takahiro Sugiura, Takahito Imaizumi, Jun Imai, Yukari Hoshina, Yasushi Hirasawa
Nihon Bioresearch Inc
Journal of Pharmacological Sciences 124 (suppl) 237-237, 2014.

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P3-15-3 Single and multiple antigen challenge-induced interleukin (IL)-33 production in the lung of asthmatic mouse, and effect of dexamethasone on them

Ayumi Nishiguchi1, Anna Takiguchi1, Haruka Kida1, Hiroki Wakamori1, Chihiro Yano1, Nobuaki Mizutani2, Shin Yoshino2, Susumu Ohya1, Takeshi Nabe1
1Dept. Pharmacol., Kyoto Pharm. Univ, 2Dept. Pharmacol., Kobe Pharm. Univ
Journal of Pharmacological Sciences 124 (suppl) 237-237, 2014.

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P3-15-4 Adrenoceptor-mediated enhancement of REDD1 gene expression in macrophages

Sachiko Hiraide, Yoshiki Yanagawa, Machiko Matsumoto, Hiroko Togashi
Dept. Pharmacol, Sch. Pharmaceu. Sci., Health Sci. Univ. of Hokkaido
Journal of Pharmacological Sciences 124 (suppl) 237-237, 2014.

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P3-15-5 Binding properties of monoclonal antibodies against the extracellular domains of mouse aquaporin-4 that influence endocytosis of aquaporin-4 and complement-dependent cytotoxicity

Ping Huang1, Yoshiki Takai1,2, Yoichiro Abe1, Osamu Arai3, Hiroko Iwanari3, Julia Ramadhanti1, Takayuki Miyauchi1, Wakami Goda1, Manae Imamura1, Mizuki Okada1, Kaori Miyazaki1, Toshiko Sakihama3, Takao Hamakubo3, Kazuo Fujihara4, Masato Yasui1
1Dept. Pharmacol. Keio Univ. Sch. Med, 2Dept. Neurol. Tohoku Univ. Sch. Med, 3Quantitative Biol. Med., RCAST, Univ. Tokyo, 4Dept. Multiple Sclerosis Therapeutics, Tohoku Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 237-237, 2014.

全文ダウンロード：従量制、基本料金制の方共に121円(税込) です。

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P3-15-6 Effects of Clarithromycin on translatome of LPS-treated or untreated B-lymphoblastoid cells

Hiromi Takano-Ohmuro1, Takahiro Nakashinden2, Tomohito Kakegawa2
1Fac. Pharmacy & Res. Inst. Pharmaceutical Sci., Musashino Univ, 2Fac. Pharmaceut. Sci., Josai International Univ
Journal of Pharmacological Sciences 124 (suppl) 238-238, 2014.

全文ダウンロード：従量制、基本料金制の方共に121円(税込) です。

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P3-15-7 mDia, an actin nucleator of formin family, functions in T cell activation

Kiyoshi Tohyama1, Dean Thumkeo1,2, Shuh Narumiya1,2
1Dept. Pharm, Kyoto Univ. Grad. Sch. Med, 2AK project, Kyoto Univ. Grad. Sch. Med
Journal of Pharmacological Sciences 124 (suppl) 238-238, 2014.

全文ダウンロード：従量制、基本料金制の方共に121円(税込) です。

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