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CYP2D in the Brain
Yoshihiko FUNAE, Wataru KISHIMOTO, Toshio CHO, Toshiro NIWA, Toyoko HIROI
Department of Chemical Biology, Osaka City University, Medical School, Osaka, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 337-349, 2003.
Department of Chemical Biology, Osaka City University, Medical School, Osaka, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 337-349, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Estimation of Bioavailability of Salmon Calcitonin from the Hypocalcemic Effect in Rats (I) : Pharmacokinetic-Pharmacodynamic Modeling Based on the Endogenous Ca Regulatory System
Makoto MIYAZAKI*1, Susumu NAKADE*1, Kazunori IWANAGA*1, Kazuhiro MORIMOT0*2, Masao KAKEMI*1
*1Department of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan, *2Department of Pharmaceutics, Hokkaido College of Pharmacy, Otaru, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 350-357, 2003.
*1Department of Pharmaceutics, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan, *2Department of Pharmaceutics, Hokkaido College of Pharmacy, Otaru, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 350-357, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Estimation of Bioavailability of Salmon Calcitonin from the Hypocalcemic Effect in Rats (II) : Effect of Protease Inhibitor on the Pharmacokinetic-Pharmacodynamic Relationship after Intranasal Administration
Makoto MIYAZAKI*1, Susumu NAKADE*1, Kazunori IWANAGA*1, Kazuhiro MORIMOT0*2, Masao KAKEMI*1
*1Department of Pharmaceutics. Osaka University of Pharmaceutical Sciences, Takatsuki, Japan, *2Department of Pharmaceutics, Hokkaido College of Pharmacy, Otaru, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 358-364, 2003.
*1Department of Pharmaceutics. Osaka University of Pharmaceutical Sciences, Takatsuki, Japan, *2Department of Pharmaceutics, Hokkaido College of Pharmacy, Otaru, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 358-364, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
The Intestinal First-pass Metabolism of Substrates of CYP3A4 and P-glycoprotein -Quantitative Analysis Based on Information from the Literature
Motohiro KATO*1, Koji CHIBA*2, Akihiro HISAKA*3, Michi ISHIGAMI*4, Makoto KAYAMA*5, Naomi MIZUN0*6, Yoshinori NAGATA*7, Susumu TAKAKUWA*8, Yuko TSUKAMOT0*9, Kaoru UEDA*10, Hiroyuki KUSUHARA*11, Kiyomi IT0*12, Yuichi SUGIYAMA*11
*1Pre-clinical Research Dept. I, Chugai Pharmaceutical Co. Ltd., Gotemba, Japan, *2Clinical Pharmacology Group, Pfizer Japan Inc., Tokyo, Japan, *3Clinical Pharmacology & Development, Banyu Pharmaceutical Co. Ltd., Tokyo, Japan, *4Clinical Pharmacology Department, Sankyo Co. Ltd., Tokyo, Japan, *5Project Coordination Department, Yamanouchi Pharmacentical Co. Ltd., Tokyo, Japan, *6Pharmacokinetics Laboratory, Mitsubishi Pharma, Co., Ltd., Kisarazu, Japan, *7Pharmacokinetic Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan, *8Drug Metabolism and Pharmacokinetics Section, Eisai Co., Ltd, Tsukuba, Japan, *9Clinical Pharmacology Department., Novartis Pharma K. K., Tokyo, Japan, *10Planning & Control Department. Teikoku Hormone MFG. Co., Ltd., Kanagawa, Japan, *11Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan, *12Department of Clinical Pharmacokinetics, Hoshi University, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 365-372, 2003.
*1Pre-clinical Research Dept. I, Chugai Pharmaceutical Co. Ltd., Gotemba, Japan, *2Clinical Pharmacology Group, Pfizer Japan Inc., Tokyo, Japan, *3Clinical Pharmacology & Development, Banyu Pharmaceutical Co. Ltd., Tokyo, Japan, *4Clinical Pharmacology Department, Sankyo Co. Ltd., Tokyo, Japan, *5Project Coordination Department, Yamanouchi Pharmacentical Co. Ltd., Tokyo, Japan, *6Pharmacokinetics Laboratory, Mitsubishi Pharma, Co., Ltd., Kisarazu, Japan, *7Pharmacokinetic Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan, *8Drug Metabolism and Pharmacokinetics Section, Eisai Co., Ltd, Tsukuba, Japan, *9Clinical Pharmacology Department., Novartis Pharma K. K., Tokyo, Japan, *10Planning & Control Department. Teikoku Hormone MFG. Co., Ltd., Kanagawa, Japan, *11Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan, *12Department of Clinical Pharmacokinetics, Hoshi University, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 365-372, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Novel Organic Nitrate Prodrug 4(R)-N-(2-Nitroxyethyl)-2-Oxothiazolidine-4-Carboxamide (RS-7897) Serves as a Xenobiotic Substrate for Pyroglutamyl Aminopeptidase I in Dogs
Koji ABE*1, Makiko YAMADA*1, Toshio TERAO*1, Hiroshi MIZUN0*2, Yuko MATSUOKA*2, Ryosuke YORIKANE*2, Taro TOKUI*1, Toshihiko IKEDA*1
*1Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan, *2Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 373-380, 2003.
*1Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan, *2Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 373-380, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Involvement of Multiple Transport Systems in the Disposition of an Active Metabolite of a Prodrug-type New Quinolone Antibiotic, Prulifloxacin
Yukihiro YAGI*1, Sachiyo SHIBUTANI*1, Naoko HODOSHIMA*1, Kazuya ISHIWATA*1, Noriko OKUDAIRA*1, Qing LI*2, Yoshimichi SAI*2, Yukio KAT0*2, Akira TSUJI*2
*1Toxicology & Pharmacokinetics Research Labs. , Pharmaceutical Development Department, Meiji Seika Kaisha, LTD. , Yokohama, Japan, *2Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 381-389, 2003.
*1Toxicology & Pharmacokinetics Research Labs. , Pharmaceutical Development Department, Meiji Seika Kaisha, LTD. , Yokohama, Japan, *2Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 381-389, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
New SRM Data Dependent Exclusion (MS)n Measurement for Structural Determination of Drug Metabolites Using LC/ESI/Ion Trap MS
Zenzaburo TOZUKA, Hayato KANEKO, Toshifumi SHIRAGA, Manabu BEPPU, Toshiro NIWA, Akio KAWAMURA, Akira KAGAYAMA
Biopharmaceutical and Pharmacokinetics Research Laboratories Fujisawa Pharmaceutical Co. , Ltd. , Osaka, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 390-403, 2003.
Biopharmaceutical and Pharmacokinetics Research Laboratories Fujisawa Pharmaceutical Co. , Ltd. , Osaka, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 390-403, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Comparative Study of Flux of FITC-labeled Dextran 4000 on Normal (iso)- and Hyper-osmolarity in Basal Side in Caco-2 Cell Monolayers
Rie OHKUBO, Mikio TOMITA, Yoshiyuki HOTTA, Mayuko NAGIRA, Masahiro HAYASHI
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 404-408, 2003.
Department of Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 404-408, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Decreased Function of Genetic Variants, Pro283Leu and Arg287Gly, in Human Organic Cation Transporter hOCT1
Ayako TAKEUCHI, Hideyuki MOTOHASHI, Masahiro OKUDA, Ken-ichi INUI
Department of Pharmacy. Kyoto University Hospital, Kyoto, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 409-412, 2003.
Department of Pharmacy. Kyoto University Hospital, Kyoto, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 409-412, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Twenty-six Novel Single Nucleotide Polymorphisms and their Frequencies of the NR1I3 (CAR) Gene in a Japanese Population
Shinobu IKEDA*1, Kouichi KUROSE*1,2, Shogo OZAWA*1,3, Kimie SAI*1,4, Ryuichi HASEGAWA*2, Kazuo KOMAMURA*5,6, Kazuyuki UENO*7, Shiro KAMAKURA*5, Masafumi KITAKAZE*5, Hitonobu TOMOIKE*5, Toshiharu NAKAJIMA*8, Kenji MATSUMOT0*8, Hirohisa SAITO*8, Yu-ichi GOTO*9, Hideo KIMURA*9, Masaaki KATOH*10, Kenji SUGAI*10, Narihiro MINAMI*9,10, Kuniaki SHIRAO*11, Tomohide TAMURA*11, Noboru YAMAMOTO*11, Hironobu MINAMI*12, Atsushi OHTSU*13, Teruhiko YOSHIDA*14, Nagahiro SAIJO*11, Yoshiro SAITO*1,15, Jun-ichi SAWADA*1,15
*1Project team for Pharmacogenetics, *2Division of Medicinal Safety Science, *3Division of Pharmacology, *4Division of Xenobiotic Metabolism and Disposition, *15Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan, *5Division of Cardiology, *6Research Institute, *7Department of Pharmacy, National Cardiovascular Center, Osaka, Japan, *8Department of Allergy and Immunology, National Research Institute for Child Health and Development, National Center for Child Health and Development, Tokyo, Japan, *9National Institute of Neuroscience, *10National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan, *11Division of Internal Medicine, National Cancer Center Hospital, *14Genetics Division, National Cancer Center Research Institute, Tokyo, Japan, *12Division of Oncology/Hematology, *13Division of GI Oncology/Digestive Endoscopy, National Cancer Center Hospital East, Chiba, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 413-418, 2003.
*1Project team for Pharmacogenetics, *2Division of Medicinal Safety Science, *3Division of Pharmacology, *4Division of Xenobiotic Metabolism and Disposition, *15Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan, *5Division of Cardiology, *6Research Institute, *7Department of Pharmacy, National Cardiovascular Center, Osaka, Japan, *8Department of Allergy and Immunology, National Research Institute for Child Health and Development, National Center for Child Health and Development, Tokyo, Japan, *9National Institute of Neuroscience, *10National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan, *11Division of Internal Medicine, National Cancer Center Hospital, *14Genetics Division, National Cancer Center Research Institute, Tokyo, Japan, *12Division of Oncology/Hematology, *13Division of GI Oncology/Digestive Endoscopy, National Cancer Center Hospital East, Chiba, Japan
DRUG METABOLISM AND PHARMACOKINETICS 18 (6) 413-418, 2003.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
