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Cancer Prevention by Natural Compounds
Hiroyuki TSUDA*1*2, Yutaka OHSHIMA*1, Hiroshi NOMOTO*2, Ken-ichi FUJITA*2, Eiji MATSUDA*2*3, Masaaki IIG0*2*3, Nobuo TAKASUKA*2*3, Malcolm A. MOORE*1*2
*1 Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, *2 Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan, *3 Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 245-263, 2004.
*1 Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, *2 Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan, *3 Cancer Prevention Basic Research Project, National Cancer Center Research Institute, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 245-263, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Transporter mRNA Expression in a Conditionally Immortalized Rat Small Intestine Epithelial Cell Line (TR-SIE)
Ken-ichi HOSOYA*1, Masatoshi TOMI*1, Megumi TAKAYAMA*1, Yuko KOMOKATA*2, Daisuke NAKAI*2, Taro TOKUI*2, Kenji NISHIMURA*2, Masatsugu UEDA*3, Masuo OBINATA*4, Satoko HORI*5*6, Sumio OHTSUKI*5*6, Gordon L. AMIDON*7, Tetsuya TERASAKI*5*6
*1 Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan, *2 Pharmacokinetics and Drug Delivery Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan, *3 The YS Institute, Inc., Utsunomiya, Tochigi, Japan, *4 Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, *5 Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, *6 New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan, *7 College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 264-269, 2004.
*1 Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan, *2 Pharmacokinetics and Drug Delivery Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan, *3 The YS Institute, Inc., Utsunomiya, Tochigi, Japan, *4 Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, *5 Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, *6 New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan, *7 College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 264-269, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Tolbutamide Uptake Via pH- and Membrane-potential-dependent Transport Mechanism in Mouse Brain Capillary Endothelial Cell Line
Noriko KOYABU*1, Hitomi TAKANAGA*1, Hirotami MATSUO*1, Mikihiko NAITO*2, Takashi TSURUO*2, Hisakazu OHTANI*1, Yasufumi SAWADA*1
*1 Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, *2 Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 270-279, 2004.
*1 Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, *2 Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 270-279, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Effects of Continuous Ingestion of Green Tea or Grape Seed Extracts on the Pharmacokinetics of Midazolam
Masataka NISHIKAWA*1, Noritaka ARIYOSHI*2, Akira KOTANI*3, Itsuko ISHII*1, Hiroyoshi NAKAMURA*2, Hiromitsu NAKASA*2, Mayuri IDA*1, Hideo NAKAMURA*4, Nobuhito KIMURA*4, Maharu KIMURA*2, Atsushi HASEGAWA*2, Fumiyo KUSU*3, Shigeru OHMORI*5, Kazuyoshi NAKAZAWA*2, Mitsukazu KITADA*2
*1 Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan, *2 Division of Pharmacy, University Hospital, Chiba University School of Medicine, Chiba, Japan, *3 School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan, *4 Tokiwa Phytochemical Co., Chiba, Japan, *5 Division of Pharmacy, Shinsyu University Hospital, Nagano, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 280-289, 2004.
*1 Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan, *2 Division of Pharmacy, University Hospital, Chiba University School of Medicine, Chiba, Japan, *3 School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan, *4 Tokiwa Phytochemical Co., Chiba, Japan, *5 Division of Pharmacy, Shinsyu University Hospital, Nagano, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 280-289, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Enhancement of Acetaminophen Cytotoxicity in Selenium-binding Protein-overexpressed COS-1 Cells
Takumi ISHIDA*1, Masamiki ABE*1, Kazuta OGURI*2, Hideyuki YAMADA*1
*1 Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, *2 Faculty of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Miyazaki, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 290-296, 2004.
*1 Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan, *2 Faculty of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Miyazaki, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 290-296, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Kinetic Studies of Covalent Binding between N-acetyl-L-cysteine and Human Serum Albumin Through a Mixed-disulfide Using an N-methylpyridinium Polymer-based Column
Daisuke HARADA*1, Makoto ANRAKU*2, Hikaru FUKUDA*2, Shinsaku NAITO*1, Kumiko HARADA*2, Ayaka SUENAGA*2, Masaki OTAGIRI*2
*1 Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan, *2 Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 297-302, 2004.
*1 Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan, *2 Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 297-302, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Genotyping of Single Nucleotide Polymorphisms (SNPs) Influencing Drug Response by Competitive Allele-specific Short Oligonucleotide Hybridization (CASSOH) with Immunochromatographic Strip
Masahiro HIRATSUKA*1, Aiko EBISAWA*1, Yoichi MATSUBARA*2, Shigeo KURE*2, Yumiko KONNO*1, Takamitsu SASAKI*1, Michinao MIZUGAKI*1
*1 Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University, Sendai, Japan, *2 Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 303-307, 2004.
*1 Department of Clinical Pharmaceutics, Tohoku Pharmaceutical University, Sendai, Japan, *2 Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 303-307, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Seven Novel Single Nucleotide Polymorphisms in the Human SLC22A1 Gene Encoding Organic Cation Transporter 1(OCT1)
Masaya ITODA*1, Yoshiro SAITO*1*2, Keiko MAEKAWA*1*2, Hiroyuki HICHIYA*1, Kazuo KOMAMURA*3*4, Shiro KAMAKURA*3, Masafumi KITAKAZE*3, Hitonobu TOMOIKE*3, Kazuyuki UENO*5, Shogo OZAWA*1*6, Jun-ichi SAWADA*1*2
*1 Project team for Pharmacogenetics, *2 Division of Biochemistry and Immunochemistry, *6 Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan, *3 Department of Cardiology, *4 Department of Cardiovascular Dynamics Research Institute, National Cardiovascular Center, Suita, Japan, *5 Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 308-312, 2004.
*1 Project team for Pharmacogenetics, *2 Division of Biochemistry and Immunochemistry, *6 Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan, *3 Department of Cardiology, *4 Department of Cardiovascular Dynamics Research Institute, National Cardiovascular Center, Suita, Japan, *5 Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 308-312, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Novel Nonsynonymous Single Nucleotide Polymorphisms in the CYP2D6 Gene
Akiko SOYAMA, Takashi KUBO, Atsuko MIYAJIMA 5), Yoshiro SAITO 1), Kisho SHISEKI, Kazuo KOMAMURA 2)3), Kazuyuki UENO 4), Shiro KAMAKURA 2), Masafumi KITAKAZE 2), Hitonobu TOMOIKE 2), Shogo OZAWA 5), Jun-ichi SAWADA 1)
Project team for Pharmacogenetics, 1)Division of Biochemistry and Immunochemistry, 5)Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan, 2)Department of Cardiology, 3)Department of Cardiovascular Dynamics Research Institute, 4)Department of Pharmacy, National Cardiovascular Center, Osaka, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 313-319, 2004.
Project team for Pharmacogenetics, 1)Division of Biochemistry and Immunochemistry, 5)Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan, 2)Department of Cardiology, 3)Department of Cardiovascular Dynamics Research Institute, 4)Department of Pharmacy, National Cardiovascular Center, Osaka, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 313-319, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Genetic Variations of the AHR Gene Encoding Aryl Hydrocarbon Receptor in a Japanese Population
Hiromi FUKUSHIMA-UESAKA*1, Kimie SAI*1*2, Keiko MAEKAWA*1*3, Satoru KOYANO*1, Nahoko KANIWA*1*4, Shogo OZAWA*1*5, Manabu KAWAMOTO*6, Naoyuki KAMATANI*6, Kazuo KOMAMURA*7*8, Shiro KAMAKURA*7, Masafumi KITAKAZE*7, Hitonobu TOMOIKE*7, Kazuyuki UENO*9, Hironobu MINAMI*10, Atsushi OHTSU*11, Kuniaki SHIRAO*12, Teruhiko YOSHIDA*13, Nagahiro SAIJO*12, Yoshiro SAITO*1*3, Jun-ichi SAWADA*1*3
*1 Project team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan, *2 Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences, Tokyo, Japan, *3 Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan, *4 Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan, *5 Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan, *6 Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, Tokyo Women's is Medical University, Tokyo, Japan, *7 Division of Cardiology, National Cardiovascular Center, Osaka, Japan, *8 Department of Cardiovascular Dynamics Research Institute, National Cardiovascular Center, Osaka, Japan, *9 Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan, *10 Division of Oncology/Hematology, National Cancer Center Hospital East, Chiba, Japan, *11 Division of GI Oncology/Digestive Endoscopy, National Cancer Center Hospital East, Chiba, Japan, *12 Division of Internal Medicine, National Cancer Center Hospital, *13 Genetics Division, National Cancer Center Research Institute, National Cancer Center, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 320-326, 2004.
*1 Project team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan, *2 Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences, Tokyo, Japan, *3 Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan, *4 Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan, *5 Division of Pharmacology, National Institute of Health Sciences, Tokyo, Japan, *6 Division of Genomic Medicine, Department of Advanced Biomedical Engineering and Science, Tokyo Women's is Medical University, Tokyo, Japan, *7 Division of Cardiology, National Cardiovascular Center, Osaka, Japan, *8 Department of Cardiovascular Dynamics Research Institute, National Cardiovascular Center, Osaka, Japan, *9 Department of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan, *10 Division of Oncology/Hematology, National Cancer Center Hospital East, Chiba, Japan, *11 Division of GI Oncology/Digestive Endoscopy, National Cancer Center Hospital East, Chiba, Japan, *12 Division of Internal Medicine, National Cancer Center Hospital, *13 Genetics Division, National Cancer Center Research Institute, National Cancer Center, Tokyo, Japan
DRUG METABOLISM AND PHARMACOKINETICS 19 (4) 320-326, 2004.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
