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The Impact of Pharmacogenomics Research on Drug Development
Shyh-Yuh LIOU1, Fran STRINGER2, Masashi HIRAYAMA1
1Clinical Data Science Department, Japan Development Center, Pharmaceutical Development Division, Takeda Pharmaceutical Company Ltd., 2Clinical Pharmacology, Takeda Global Research & Development Centre (Europe) Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 2-8, 2012.
1Clinical Data Science Department, Japan Development Center, Pharmaceutical Development Division, Takeda Pharmaceutical Company Ltd., 2Clinical Pharmacology, Takeda Global Research & Development Centre (Europe) Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 2-8, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
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Population Differences in Major Functional Polymorphisms of Pharmacokinetics/pharmacodynamics-related Genes in Eastern Asians and Europeans: Implications in the Clinical Trials for Novel Drug Development
Kouichi KUROSE, Emiko SUGIYAMA, Yoshiro SAITO
Division of Medicinal Safety Science, National Institute of Health Sciences
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 9-54, 2012.
Division of Medicinal Safety Science, National Institute of Health Sciences
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 9-54, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance
Lay Kek TEH1, Leif BERTILSSON2
1Pharmacogenomics Centre (PROMISE), Faculty of Pharmacy, Universiti Teknologi MARA, 2Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University, Hospital-Huddinge, Karolinska Institutet
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 55-67, 2012.
1Pharmacogenomics Centre (PROMISE), Faculty of Pharmacy, Universiti Teknologi MARA, 2Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska University, Hospital-Huddinge, Karolinska Institutet
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 55-67, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
In Vitro Assessment of the Allelic Variants of Cytochrome P450
Masahiro HIRATSUKA
Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 68-84, 2012.
Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 68-84, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Functional Significance of Genetic Polymorphisms in P-glycoprotein (MDR1, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2)
Ichiro IEIRI
Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 85-105, 2012.
Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 85-105, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of Drugs
Takeo NAKANISHI, Ikumi TAMAI
Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Kanazawa University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 106-121, 2012.
Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Kanazawa University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 106-121, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Pharmacogenomics of Tamoxifen: Roles of Drug Metabolizing Enzymes and Transporters
Kazuma KIYOTANI3, Taisei MUSHIRODA1, Yusuke NAKAMURA1,2, Hitoshi ZEMBUTSU2
1Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, 2Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 3Division of Genome Medicine, Institute for Genome Research, The University of Tokushima
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 122-131, 2012.
1Laboratory for Pharmacogenetics, RIKEN Center for Genomic Medicine, 2Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 3Division of Genome Medicine, Institute for Genome Research, The University of Tokushima
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 122-131, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
A Recent Update of Pharmacogenomics in Drug-induced Severe Skin Reactions
Chun-Yu WEI, Tai-Ming KO, Chen-Yang SHEN, Yuan-Tsong CHEN
Institute of Biomedical Sciences, Academia Sinica
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 132-141, 2012.
Institute of Biomedical Sciences, Academia Sinica
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 132-141, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Similarities and Differences between US and Japan as to Pharmacogenomic Biomarker Information in Drug Labels
Yasuto OTSUBO1, Yasuko ASAHINA2, Atsushi NOGUCHI3, Yumiko SATO3, Yuki ANDO4, Yoshiaki UYAMA2,5
1Office of New Drug II, Pharmaceuticals and Medical Devices Agency (PMDA), 2Regulatory Science Research Division, Office of Regulatory Science, Pharmaceuticals and Medical Devices Agency (PMDA), 3Office of New Drug III, Pharmaceuticals and Medical Devices Agency (PMDA), 4Biostatistics Group, Center for Product Evaluation, Pharmaceuticals and Medical Devices Agency (PMDA), 5Department of Regulatory Science and Public Administration of Medicine, Graduate School of Advanced Clinical Sciences, Chiba University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 142-149, 2012.
1Office of New Drug II, Pharmaceuticals and Medical Devices Agency (PMDA), 2Regulatory Science Research Division, Office of Regulatory Science, Pharmaceuticals and Medical Devices Agency (PMDA), 3Office of New Drug III, Pharmaceuticals and Medical Devices Agency (PMDA), 4Biostatistics Group, Center for Product Evaluation, Pharmaceuticals and Medical Devices Agency (PMDA), 5Department of Regulatory Science and Public Administration of Medicine, Graduate School of Advanced Clinical Sciences, Chiba University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 142-149, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Effect of Histidine-tag and R457H and E580Q Mutations on Catalytic Activity of Recombinant Human Cytochrome P450 Oxidoreductase
Toshiro NIWA, Katsuhito MINAMI, Masanao KATAGIRI
Division of Natural Science, Osaka Kyoiku University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 150-154, 2012.
Division of Natural Science, Osaka Kyoiku University
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 150-154, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
Metabolism and Pharmacokinetic Studies of JPH203, an L-Amino Acid Transporter 1 (LAT1) Selective Compound
Michael F. WEMPE1, Peter J. RICE1,2, Janet W. LIGHTNER2, Promsuk JUTABHA3, Michinari HAYASHI3, Naohiko ANZAI3,4, Shin WAKUI5, Hiroyuki KUSUHARA6, Yuichi SUGIYAMA6, Hitoshi ENDOU3,7
1School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, 2Department of Pharmacology, East Tennessee State University, 3Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 4Dokkyo Medical University School of Medicine, 5Azabu University School of Veterinary Medicine, 6Faculty of Pharmaceutical Sciences, University of Tokyo, 7J-Pharma Co., Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 155-161, 2012.
1School of Pharmacy, University of Colorado Denver, Anschutz Medical Campus, 2Department of Pharmacology, East Tennessee State University, 3Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 4Dokkyo Medical University School of Medicine, 5Azabu University School of Veterinary Medicine, 6Faculty of Pharmaceutical Sciences, University of Tokyo, 7J-Pharma Co., Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 155-161, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
The Exposure of Luteolin Is Much Lower than That of Apigenin in Oral Administration of Flos Chrysanthemi Extract to Rats
Zhongjian CHEN1, Meijuan TU1, Siyuan SUN1, Sisi KONG1, Yuqing WANG1, Jiangfeng YE2, Liping LI1, Su ZENG1, Huidi JIANG1
1Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, 2Zhejiang Conba Pharmaceutical Co., Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 162-168, 2012.
1Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, 2Zhejiang Conba Pharmaceutical Co., Ltd.
DRUG METABOLISM AND PHARMACOKINETICS 27 (1) 162-168, 2012.
- アブストラクト： 従量制は110円（税込）、基本料金制は基本料金に含まれます。
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
