バックナンバー：Chemical and Pharmaceutical Bulletin

Chemical and Pharmaceutical Bulletin
67巻 3号

  • Current Topics Drug Discovery : Recent Progress and the Future Foreword

    Akira Otaka
    Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University
    Chemical and Pharmaceutical Bulletin 67(3): 163-164, 2019.


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  • Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein

    Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    Divisions of Molecular Target and Gene Therapy Products, National Institute of Health Sciences
    Chemical and Pharmaceutical Bulletin 67(3): 165-172, 2019.


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  • The Latest Research and Development into the Antibody-Drug Conjugate, [fam-] Trastuzumab Deruxtecan (DS-8201a), for HER2 Cancer Therapy

    Takashi Nakada, Kiyoshi Sugihara, Takahiro Jikoh, Yuki Abe, Toshinori Agatsuma
    Research and Development Division, Daiichi Sankyo Co.,Ltd.
    Chemical and Pharmaceutical Bulletin 67(3): 173-185, 2019.


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  • Potential Anticancer Activity of Auranofin

    Takefumi Onodera, Isao Momose, Manabu Kawada
    Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation
    Chemical and Pharmaceutical Bulletin 67(3): 186-191, 2019.


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  • Design, Synthesis, and Biological Evaluation of a Conjugate of 5-Fluorouracil and an LSD1 Inhibitor

    Yosuke Ota(a), Arisa Nakamura(a), Elghareeb E.Elboray(a),(b), Yukihiro Itoh(a), Takayoshi Suzuki(a),(c)
    (a)Graduate School of Medical Science, Kyoto Prefectural University of Medicine, (b)Chemistry Department, Faculty of Science, South Valley University, and (c)CREST, Japan Science and Technology Agency (JST)
    Chemical and Pharmaceutical Bulletin 67(3): 192-195, 2019.


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  • Palladium-Catalyzed C-H Heteroarylation of 2,5-Disubstituted Imidazoles

    Takaya Togo(a), Youhei Sohma(a), Yoichiro Kuninobu(b), Motomu Kanai(a)
    (a)Graduate School of Pharmaceutical Sciences, The University of Tokyo, and (b)Institute for Materials Chemistry and Engineering, Kyushu University
    Chemical and Pharmaceutical Bulletin 67(3): 196-198, 2019.


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  • Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome

    Keisuke Tachibana(a), Kenji Ishimoto(a), Rika Takahashi(a), Hirokazu Kadono(a), Takuya Awaji(a), Tomohiro Yuzuriha(b), Toshiya Tanaka(c), Takao Hamakubo(d), Juro Sakai(e), Tatsuhiko Kodama(c), Shunji Aoki(f), Takefumi Doi(a)
    (a)Graduate School of Pharmaceutical Sciences, Osaka University, (b)Faculty of Pharmaceutical Sciences, Setsunan University, (c)Laboratory for System Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, (d)Department of Protein-Protein Interaction Research, Institute for Advanced Medical Sciences, Nippon Medical School, (e)Division of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, and (f)School of Pharmacy, Hyogo University of Health Sciences
    Chemical and Pharmaceutical Bulletin 67(3): 199-202, 2019.


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  • Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)

    Nobumichi Ohoka(a), Osamu Ujikawa(b),†, Kenichiro Shimokawa(b), Tomoya Sameshima(b), Norihito Shibata(a), Takayuki Hattori(a), Hiroshi Nara(b),‡, Nobuo Cho(b),§, Mikihiko Naito(a)
    (a)Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, and (b)Pharmaceutical Research Division, Takeda Pharmaceutical Co.,Ltd., †Present address:Axcelead Drug Discovery Partners, Inc., ‡Present address:The Pharmaceutical Society of Japan, §Present address:Drug Discovery Chemistry Platform Unit, Drug Discovery Platforms Cooperation Division, RIKEN Center for Sustainable Resource Science
    Chemical and Pharmaceutical Bulletin 67(3): 203-209, 2019.


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  • Structure-Activity Relationship of Biakamide, Selective Growth Inhibitors under Nutrient-Starved Condition from Marine Sponge

    Ryosuke Ishida, Hirokazu Matsumoto, Sayaka Ichii, Motomasa Kobayashi, Masayoshi Arai, Naoyuki Kotoku†
    Graduate School of Pharmaceutical Sciences, Osaka University, †Present address:Colleges of Pharmaceutical Sciences, Ritsumeikan University
    Chemical and Pharmaceutical Bulletin 67(3): 210-223, 2019.


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  • Bis-Heteroaryl Pyrazoles : Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H)

    Katsuhiko Sekimata(a), Tomohiro Sato(b), Naoki Sakai(c), Hisami Watanabe(c), Chiemi Mishima-Tsumagari(c), Tomonori Taguri(a), Takehisa Matsumoto(c), Yoshifumi Fujii(d), Noriko Handa(d), Teruki Honma(b), Akiko Tanaka(c), Mikako Shirouzu(c), Shigeyuki Yokoyama(d), Kohei Miyazono(e), Yoshinobu Hashizume(f), Hiroo Koyama(a)
    (a)Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science, (b)Drug Discovery Computational Chemistry Platform Unit, RIKEN Center for Biosystems Dynamics Research, (c)Drug Discovery Structural Biology Platform Unit, RIKEN Biosystems Dynamics Research, (d)Crystallographic Drug Discovery Platform Unit, RIKEN Systems and Structural Biology Center, (e)Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, and (f)RIKEN Program for Drug Discovery and Medical Technology Platforms
    Chemical and Pharmaceutical Bulletin 67(3): 224-235, 2019.


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  • Spontaneously Cleavable Glycosylated Linker Capable of Extended Release of Its Conjugated Peptide

    Hirofumi Ochiai, Kenta Yoshida†, Hiroshi Shibutani, Akio Kanatani, Yuji Nishiuchi
    GlyTech, Inc., †Present address:Earth Corporation
    Chemical and Pharmaceutical Bulletin 67(3): 236-243, 2019.


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  • YiQi Tongluo Granule against Cerebral Ischemia/Reperfusion Injury in Rats by Freezing GluN2B and CaMK II through NMDAR/ERK1/2 Signaling

    Si-peng Wu(a),(b),(c), Dan Li(d), Ning Wang(a),(b),(c), Jin-cai Hou(c), Li Zhao(a),(b),(c)
    (a)Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, (b)Institute for Pharmacodynamics and Safety Evaluation of Chinese Medicine, Anhui Academy of Chinese Medicine, (c)Key Laboratory of Xin'an Medicine, Ministry of Education, and (d)Jing-Jin-Ji Joint Innovation Pharmaceutical (Beijing) Co.,Ltd.
    Chemical and Pharmaceutical Bulletin 67(3): 244-252, 2019.


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  • Convergent Synthesis of trans-2,6-Disubstituted Piperidine Alkaloid, (-)-iso-6-Spectaline by Palladium-Catalyzed Cyclization

    Risako Kameda(a), Takuto Sohma(a), Kazuya Kobayashi(a), Ryosuke Uchiyama(b), Kazuto Nosaka(b), Hiroyuki Konno(c), Kenichi Akaji(a), Yasunao Hattori(d)
    (a)Department of Medicinal Chemistry, Kyoto Pharmaceutical University, (b)2nd Department of Biochemistry, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, (c)Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University, and (d)Center for Instrumental Analysis, Kyoto Pharmaceutical University
    Chemical and Pharmaceutical Bulletin 67(3): 253-257, 2019.


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  • A Retrospective Analysis of the Effect of Tigecycline on Coagulation Function

    Bing Leng(a), Yuan Chao Xue(b), Wen Zhang(a), Tian tian Gao(a), Gen quan Yan(a), Hui Tang(a),(b)
    (a)Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong University, and (b)Centre for Heart Lung Innovation, St.Paul's Hospital and Department of Pathology and Laboratory Medicine, University of British Columbia
    Chemical and Pharmaceutical Bulletin 67(3): 258-264, 2019.


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  • A Novel Approach to Evaluate Amorphous-to-Crystalline Transformation of Active Pharmaceutical Ingredients in Solid Dispersion Using Time-Domain NMR

    Kotaro Okada(a), Daijiro Hirai(b), Yoshihiro Hayashi(a),(b), Shungo Kumada(b), Atsushi Kosugi(b), Yoshinori Onuki(a)
    (a)Department of Pharmaceutical Technology, Graduate School of Medical and Pharmaceutical Science, University of Toyama, and (b)Nichi-Iko Pharmaceutical Co.,Ltd., Formulation Development Department
    Chemical and Pharmaceutical Bulletin 67(3): 265-270, 2019.


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  • A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules

    Terushi Ito(a), Kotaro Okada(a), Kok Hoong Leong(b), Daijiro Hirai(c), Yoshihiro Hayashi(a),(c), Shungo Kumada(c), Atsushi Kosugi(c), Yoshinori Onuki(a)
    (a)Department of Pharmaceutical Technology, Graduate School of Medical and Pharmaceutical Science, University of Toyama, (b)Department of Pharmacy, Faculty of Medicine, University of Malaya, and (c)Nichi-Iko Pharmaceutical Co.,Ltd., Formulation Development Department
    Chemical and Pharmaceutical Bulletin 67(3): 271-276, 2019.


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  • Rheological and Adhesive Properties to Identify Cohesive and Dispersive Ophthalmic Viscosurgical Devices

    Ippei Watanabe(a), Hirotaka Hoshi(b), Miwako Sato(a), Kiyoshi Suzuki(b)
    (a)Medical Science Liaison Unit, Seikagaku Corporation, and (b)Central Research Laboratories, Seikagaku Corporation
    Chemical and Pharmaceutical Bulletin 67(3): 277-283, 2019.


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  • Potential Use of Magnesium Oxide as an Excipient to Maintain the Hardness of Orally Disintegrating Tablets during Unpackaged Storage

    Takatoshi Sakamoto(a), Shigeto Kachi(b), Shohei Nakamura(a), Hiroshi Yuasa(a),†
    (a)Department of Pharmaceutical Technology, School of Clinical Pharmacy, College of Pharmaceutical Sciences, Matsuyama University, and (b)Pharmaceuticals Division, Kyowa Chemical Industry Co.,Ltd., †Present address:School of Pharmacy, Showa University
    Chemical and Pharmaceutical Bulletin 67(3): 284-288, 2019.


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book
発行元：
日本薬学会
ISSN：
0009-2363
ISSN（オンライン）：
1347-5223

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