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Journal of Toxicologic Pathology 19巻 suppl号

発行元
日本毒性病理学会
ISSN
0914-9198
ISSN（オンライン）
1881-915X
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開始頁
S-1 Early Cancer and Precursor Lesions of Human Breast Carcinoma, from the Standpoints of Surgical Pathologists
Takuya MORIYA1), Atsuko KASAJIMA1), Shin USAMI2), Masakazu AMARI2), Ming YANG2), Mareyuki ENDOH1), Noriaki OHUCHI2), Hironobu SASANO1)
1)Pathol, 2)Surg, Tohoku Univ. Hosp. , Sendai 980-8574, Japan
Journal of Toxicologic Pathology 19 (suppl) 1-1, 2006.
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S-2 Spontaneous Mammary Tumors in Dogs and Cats
Hiroyuki NAKAYAMA
Dept. Vet. Pathol. , Univ. Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657 Japan
Journal of Toxicologic Pathology 19 (suppl) 1-1, 2006.
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S-3 Important gene expression changes for breast carcinogenesis In the c-Ha-ras transgenic rat model.
Makoto ASAMOTO, Naomi HOKAIWADO, Tomoyuki SHIRAI
Dept. of Exp. Pathol. and Tumor Biol. , Nagoya City Univ. Grad. Sch. of Med. Sci. , Nagoya 467-8601, Japan
Journal of Toxicologic Pathology 19 (suppl) 2-2, 2006.
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S-4 Progression of Early Lesions of 7,12-Dimethylbenz(a)anthracene (DMBA)-Induced Rat Mammary Carcinomas and Mammary Dysplasia
Hiroki YOSHIDA1), Hideyuki MAJIMA1), Yoshihisa UMEKITA1), Hiroaki KAWAGUCHI1), Masakazu SOUDA1 ), Takuro KODAMA1), Kazuo TOMITA1), Hiroko INDO1), Yoichiro MATSUOKA2), Hiroyuki TSUDA3)
1)The Department of tumor pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, 2)Department of Pathology II, Kansai Medical University, Moriguchi, Osaka, Japan, 3)Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Mizuho-cho, Mizuho-ku, Nagoya, Japan
Journal of Toxicologic Pathology 19 (suppl) 2-2, 2006.
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WS1-1 Points for Histopathological Examination in the Testis of Cynomolgus Monkey
Shigeru SATAKE, Hiroyuki IZUMI, Shuji SHIIDA Takao HORI, Tsuyoshi YOSHIKAWA, Junko FUJISHIMA, Tomohiro FURUKAWA, Kimiyo KAKEHI, Xiuying YANG Kimiaki HIRAKAWA, Yuki KUWAMURA, Yasuhiro KAMIMURA, Takaharu NAGAOKA, Tadayoshi KURUHARA, Yutaka CHIHAYA, Hiroshi TOKADO, Hiroshi MAEDA, Hiroaki MIYAJIMA
Shin Nippon Biomedical Laboratories, Ltd. Kagoshima, 891-1394, Japan
Journal of Toxicologic Pathology 19 (suppl) 3-3, 2006.
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WS1-2 Age-related histopathological changes in the genital organs and mammary glands in female monkeys
Takaharu NAGAOKA, Yasuhiro KAMIMURA, Kimiaki HIRAKAWA, Shigeru SATAKE, Xiuying YANG, Yuki KUWAMURA, Takao HORI, Tsuyoshi YASHIKAWA, Tomohiro FURUKAWA, Junko FUJISHIMA, Yutaka CHIAHAY, Hiroshi TOKADO, Hiroshi MAEDA, Hiroaki MIYAJIMA
Shin Nippon Biomedical Laboratories, Ltd. , Kagoshima 891-1394, Japan
Journal of Toxicologic Pathology 19 (suppl) 3-3, 2006.
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WS1-3 Toxicological pathology assessment and parasitic findings in cynomolgus monkeys
Kimiaki HIRAKAWA, Kimiyo KAKEHI, Yuki KUWAMURA, Yasuhiro KAMIMURA, Xiuying YANGS Shigeru SATAKE, Tsuyoshi YASHIKAWA, Takao HORI, Junko FUJISHIMA, Tomohiro FURUKAWA, Takaharu NAGAOKA, Yutaka CHIAHAYA, Hiroshi MAEDA, Hiroshi TOKADO, Hiroaki MIYAJIMA
Shin Nippon Biomedical Laboratories, Ltd. 891-1394, Japan
Journal of Toxicologic Pathology 19 (suppl) 4-4, 2006.
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WS1-4 Important naturally-occurring lesions in evaluation of nonhuman primate studies; focus on cardiovascular lesions and lymphomas
Yasuhiro Yoshikawa
Gifu University COE Wildlife Infectious Diseases Center, Gifu University and Faculty of Agriculture, The University of Tokyo
Journal of Toxicologic Pathology 19 (suppl) 4-4, 2006.
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WS2-1 Pathology of Drug-Induced Phospholipidosis
Ryo Fukuda
Development Research Center, Takeda Pharmaceutical Company Limited, 532-8686, Japan
Journal of Toxicologic Pathology 19 (suppl) 5-5, 2006.
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WS2-2 Metabonomics research for drug-induced phospholipidosis/steatosis
Akira HORINOUCHI1), Mika MURABAYASHI2), Hidenori KAMIGUCHI2), Ikuo MORI1)
1)Development Research Center, 2)Discovery Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, 532-8686, Japan
Journal of Toxicologic Pathology 19 (suppl) 5-5, 2006.
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WS2-3 Toxicogenomics Approaches to Drug-Induced Phospholipidosis: Identification of Candidate Blood Biomarkers and Establishment of in Vitro Screening System
Hiroshi SAWADA, Ikuo MORI, Keiko TANIGUCHI, Takako IWACHIDO, Yukie NAKASHITA, Satoru ASAHI, Kenji TAKAMI
Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited. Osaka 532-8686, Japan
Journal of Toxicologic Pathology 19 (suppl) 6-6, 2006.
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WS3-1 Hypertrophy of hepatocytes induced by drug metabolizing enzymes inducers and toxicogenomics / toxicoproteomics
Toshihiko MAKINO, Naoki KIYOSAWA, Kazumi ITO, Yosuke ANDO, Takashi YAMOTO, Munehiro TERANISHI, Sunao MANABE
Medicinal Safety Research Laboratories, Sankyo Co. , Ltd. , Shizuoka 437-0065, Japan
Journal of Toxicologic Pathology 19 (suppl) 6-6, 2006.
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WS3-2 Relationship between pathological examination and toxicogenomic or toxicoproteomic analysis: a toxicological evaluation for hepatocellular apoptosis
Kazuyoshi KUMAGAI, Naoki KIYOSAWA, Kazumi ITO, Yosuke ANDO, Ryota KAWAI, Takashi YAMOTO, Munehiro TERANISHI, Sunao MANABE
Medicinal Safety Research Laboratories, Sankyo Co. , Ltd. , 717 Horikoshi, Fukuroi, Shizuoka 437-0065, Japan
Journal of Toxicologic Pathology 19 (suppl) 7-7, 2006.
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WS3-3 Evaluation of toxicogenomic / toxicoproteomic methods for acetaminophen or bromobenzene induced hepatocellular necrosis
Dai NAKAE
Dept Pathol. , Sasaki Inst. Tokyo 101-0062 Japan
Journal of Toxicologic Pathology 19 (suppl) 7-7, 2006.
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WS3-4 Correlation of histopathological changes in hepatocytes with hepatocellular glutathione deficiency induced by buthionine-sulfoximine
Yasushi OHMACHI
National Institute of Radiological Sciences, Inage, Chiba 263-8555, Japan
Journal of Toxicologic Pathology 19 (suppl) 8-8, 2006.
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O-1 Lung Carcinogenesis Induced by NNK in Male Mice
Maki IGARASHI1)3), Midori YOSHIDA1), Masakazu TAKAHASHI1), Fumiyuki UEMATSU1), Akihiro MAEKAWA2), Dai NAKAE1)
1)Dept. Pathol. , Sasaki Inst. , Sasaki Fon. , Tokyo 101-0062, 2)Lab. Protection of body function, Dept. Food and Nutr. Sci. , Tokyo Univ. Agricul. Grad. , Tokyo 156-0054, 3)Sasaki Inst. , Sasaki Fon. , Tokyo 101-0062
Journal of Toxicologic Pathology 19 (suppl) 8-8, 2006.
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O-2 X-ray hypersensitivity and cancer susceptibilities In LEC, LEA and F344 rats
Tokiko NAKAI, Keisuke IZUMI
Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, 770-8503, Japan
Journal of Toxicologic Pathology 19 (suppl) 9-9, 2006.
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O-3 Long-term Treatment with Bromocriptine Inhibits Rat Uterine Adenocarcinoma Development
Midori YOSHIDA1), Tomo TANIMOTO1, 2), Akihiko MAEKAWA1)
1)Dept Pathol. , Saski Inst. , Tokyo, 101-0062, 2)Yakult Central Inst. Micribiol. Res. , Tokyo 186-8650, Japan
Journal of Toxicologic Pathology 19 (suppl) 9-9, 2006.
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O-4 Microencephaly and microphthalmia in rat fetuses by busulfan
Satoshi FURUKAWA, Koji USUDA, Masayoshi ABE, Izumi OGAWA
Biological Research Laboratories, Nissan Chemical Industries, Ltd. , Saitama 349-0294, Japan
Journal of Toxicologic Pathology 19 (suppl) 10-10, 2006.
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O-5 Toxicological assessments of rat adrenal gland exposed to ACAT inhibitor, K-604
Jihei NISHIMURA, Takao WATANABE, Kouzou OHMICHI, Hirofumi YAMASHITA, Tomohide AKIBA, Nobuyuki OKAMURA, Naoki KATO, Masatoshi TAKAHASHI, Eiji WATO, Takeshi TANAKA, Yukinori AMANO, Souhei TANABE
Fuji Research Laboratories, Kowa Co. , Ltd. , Shizuoka 417-8650, Japan
Journal of Toxicologic Pathology 19 (suppl) 10-10, 2006.
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O-6 Electrogene Transfer of an Epstein-Barr Virus-based Plasmid Replicon Vector containing the Diphtheria Toxin A Gene Suppresses Mammary Carcinoma Growth in SCID Mice
Masa-Aki SHIBATAI1), Junji MORIMOTO2), Yuko ITO1), Yoshinori OTSUKI1)
1)Dept. Anat. & Cell Biol. , Div. Basic Med. I, 2)Lab. Animal Ctr. , Osaka Med. Coll. , Osaka 569-8686, Japan
Journal of Toxicologic Pathology 19 (suppl) 11-11, 2006.
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O-7 Effect of System L Specific Inhibitor BCH on N-butyl-N-(4-hydroxybutyl) nitrosamine Induced Rat Bladder Carcinoma
Tomoko MUTO1, Yoshikatsu KANAI1, Shin WAKUI2, Hitoshi ENDOW
1Department of Pharmacology and Toxicology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka Tokyo 181-6811, Japan, 2Departoment of Toxicological Pathology, Azabu University of Veterinary Medicine, 1-17-71 Fuchinobe Sagamihara Kanagawa 229-8501 Japan
Journal of Toxicologic Pathology 19 (suppl) 11-11, 2006.
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O-8 Gene expression analyses on the dicyclanil-induced hepatocellular tumors in mice
Mitsuyoshi MOTO, Miwa OKAMURA, Masako MUGURUMA, Kunitoshi MITSUMORI
Lab. Vet. Pathol. , Tokyo Univ. Agrical. and Technol. , Tokyo 183-8509, Japan
Journal of Toxicologic Pathology 19 (suppl) 12-12, 2006.
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O-9 Dominant negative mutant Connexin32 enhanced progression of rat hepatocarcinogenesis.
Naomi HOKAIWADO, Makoto ASAMOTO, Tomoyuki SHIRAI
Dept. of Exp. Pathol. and Tumor Biol. , Nagoya City Univ. Grad. Sch. of Med. Sci. , Nagoya 467-8601, JAPAN
Journal of Toxicologic Pathology 19 (suppl) 12-12, 2006.
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O-10 Proteomics of GST-P positive foci as liver preneoplastic lesions regarding PB hepatocarcinogenicity in rats
Anna KINOSHITA, Hideki WANIBUCHI, Min WEI, Shoji FUKUSHIMA.
Dept. Pathol. , Osaka City Univ. Med. Sch. , Osaka 545-8585, Japan
Journal of Toxicologic Pathology 19 (suppl) 13-13, 2006.
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P-1 Brain lesions in the dog following exposure to a specific NMDA receptor antagonist
Norimitsu SHIRAI, Mamoru TAKAHASHI, Toshifumi TASHIRO, Chikako FURUTA, Aisuke NII, Ikuo HORII
Worldwide Safety Sciences, Pfizer Global Research & Development, Nagoya Laboratories, Aichi 470-2393, Japan
Journal of Toxicologic Pathology 19 (suppl) 13-13, 2006.
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P-2 Morphologic pathology research on brain differentiation of newborn rats
Toko OHIRA, Ryoko KIDO, Mari IIDA, Kayoko NAGAI, Ryo YAMASHITA, Mayumi ISHIZAKI, Yuzo YASUI, Tohru KIHARA, Kazushige HASEGAWA, Masayo HOSOI, Rumiko MIYAJIMA, Atsushi SHIGA, Hijiri IWATA, Kiyoshi IMAI.
Department of Pathology, An-pyo Center, Shizuoka, 437-1213, Japan.
Journal of Toxicologic Pathology 19 (suppl) 14-14, 2006.
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P-3 Inhibitory effects of poly(ADP-ribose) polymerase inhibitor 3-aminobenzamide on N-metyl-N-nitrosourea-induced retinal degeneration in Sprague-Dawley rats
Katsuaki MIKI1), Katsuhiko YOSHIZAWA1), 2), Airo TSUBURA1)
1)Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan, 2)Drug Safety Research Laboratories, Astellas Pharma Inc. , Osaka 532-8514, Japan
Journal of Toxicologic Pathology 19 (suppl) 14-14, 2006.
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P-4 Effects of 3-Acetylpyridine on the peripheral nerve system of Sprague-Dawley rats after single intraperitoneal administration
Jingtao JIAND, Atsuko ICHIKAWA, Yoshihiko KOBAYASHI, Miki TATE, Koichi NEDA, Toshihito KADOTA
Kobuchisawa Laboratories, Fuji Biomedix Co. , Ltd. , 10221 Kobuchisawa-cho, Kitakoma-gun, Yamanashi 408-0044, Japan
Journal of Toxicologic Pathology 19 (suppl) 15-15, 2006.
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P-5 Activity of 2', 3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) in Spongy Change of Spinal Cord Induced by a Single Oral Dose of Aniline in Rats
Tetsuro KUROTAKI, Yuri KOTANI, Yukiko KAWANO, Kotaro YAMASHITA, Minoru TSUCHITANI
Mitsubishi Chemical Safety Institute Ltd. , Ibaraki 314-0255, Japan
Journal of Toxicologic Pathology 19 (suppl) 15-15, 2006.
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P-6 Detection of the proliferation of embryonic neural stem cell using anti-phosphorylated histone 3 immunohistochemistry
Makiko KUWAGATA1), Tetsuo OGAWA2), Hideki MARUMO1), Kazunori KONNO1), Yoshiaki SAITO1), Seiji SHIODA2), Tomoko NAGATA1)
1)Lab. Pathology, Hatano Res. Inst. , Food and Drug Safety Center, Kanagawa, 257-8523, 2)Lab. Anatomy I, Sch. Med. , Showa, Univ. , Tokyo, 142-8555
Journal of Toxicologic Pathology 19 (suppl) 16-16, 2006.
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P-7 Risk assessment of chromated copper arsenate (CCA) used as a wood preservative: II. Effects on the mature rat nervous and immune system
Yukiko TAKEUCHI, Tadashi KOSAKA, Yasufumi SHUTOH, Hideaki FUJIE, Tsutomu MATSUMOTO, Koichi HAYASHI, Tomoki FUKUYAMA, Naofumi TAKAHASHI, Maki KUWAHARA, Akiko ENOMOTO, Nobuaki NAKASHIMA, Takanori HARADA
The Institute of Environmental Toxicology, Ibaraki 303-0043, Japan
Journal of Toxicologic Pathology 19 (suppl) 16-16, 2006.
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P-8 Risk assessment of chromated copper arsenate (CCA) used as a wood preservative: II. Effects on the immature rat nervous and immune systems
Maki KUWAHARA, Tadashi KOSAKA, Yasufumi SHUTOH, Hideaki FUJIE, Tsutomu MATSUMOTO, Koichi HAYASHI, Tomoki FUKUYAMA, Naofumi TAKAHASHI, Yukiko TAKEUCHI, Akiko ENOMOTO, Nobuaki NAKASHIMA, Takanori HARADA
The Institute of Environmental Toxicology, Ibaraki 303-0043, Japan
Journal of Toxicologic Pathology 19 (suppl) 17-17, 2006.
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P-9 Experimental model for idiopathic interstitial pneumonia by repeated doses of intratracheal fluorescein isothiocyanate in mice
Akika SAKAMOTO1, Kazutoshi TAMURA2, Masayuki MITSUI3, Toshihumi TSUJIUCHI4, Masahiro TSUTSUMI5
1Kyoto Prefectural University, Kyoto, 606-8522, 2Bozo Research Center, Shizuoka, 412-0039, 3Nara Medical University, Nara, 634-8522, 4Kinki University, Osaka, 577-8502, 5Saiseikai Chuwa Hospital, Nara, 633-0054, Japan
Journal of Toxicologic Pathology 19 (suppl) 17-17, 2006.
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P-10 Eosinophilic Substance is "Not Amiloid" in the Mouse Nasal Septum
Takuya DOI, Yuri KOTANI, Atsushi KUMANO, Yuki TOMONARI, Hiroko KOKOSHIMA, Takeshi KANNO, Minoru TSUCHITANI
Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, 314-0255, Japan
Journal of Toxicologic Pathology 19 (suppl) 18-18, 2006.
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P-11 7,12-dimethylbenz(a)anthracene (DMBA) induced lung Hemangiosarcoma in Long-Evans (LE) rats
Yumi WAKO, Takeshi KANNO, Tetsuro KUROTAKI, Atsushi KUMANO, Junko SATO, Minoru TSUCHITANI
Mitsubishi Chemical Safety Institute Ltd. , Ibaraki 314-0255, Japan
Journal of Toxicologic Pathology 19 (suppl) 18-18, 2006.
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P-12 Pulmonary Effects of Fullerene (C60) by Intratracheal Instillation to Rats
Akira OGAMI, Yasuo MORIMOTO
Dep. Of Occup. Pneumoi. , Inst. Of Ind. Ecol. Sci. , Univ. of Occup. & Env. Health. Fukuoka 807-8555, Japan
Journal of Toxicologic Pathology 19 (suppl) 19-19, 2006.
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P-13 Regulation system cf complement activation in normal rats : Histopathalogkal examination of membrane complement regulatory proteins
Chie KATO, Atsuhiko KATO, Shino TERUYA, Saori MATSUO, Hirotake TAKAI, Tetsuro SUGIMOTO, Masami SUZUKI
Safety As rent Dept, Chugai Phamna nutical Co, Ltd. , Shizi ka 412-8513, Japan
Journal of Toxicologic Pathology 19 (suppl) 19-19, 2006.
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P-14 Time-course study of histopathological markers for drug-induced hemolytic anemia in rats
Mihoko ONO1), Kenji NAKANO1), Kyoko ITO1), Nobuyuki IZUMISAWA1), Satoko IZUMISAWA1), Hajime TABATA1), Kinji SHIROTA2)
1)Astellas Pharma Inc. Tokyo 175-8511, 2)Azabu Univ. Kanagawa 229-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 20-20, 2006.
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P-15 Time Course Analysis of the Abdominal Aortic Banding-induced Left Ventricular Hypertrophy in Mice
Hiroyuki HIGASHIYAMA, Masaki SUGAI, Hirotaka INOUE, Yuji OKAMOTO, Kaori MIZUYACHI, Hiroshi KUSHIDA, Mine KINOSHITA, Satoshi ASANO
Pharmacology Department, Tsukuba Research Laboratories, GlaxoSmithKline K. K. , Ibaraki, 300-4247, Japan
Journal of Toxicologic Pathology 19 (suppl) 20-20, 2006.
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P-16 Left Atrial Myxomatous Thrombus with Chondroid Metaplasia and Alveolar Proteinosis in an Untreated Long Evans Female Rat
Keojien CHENG, Yachi CHIU, Hans CHEN
Greenseasons Biotech Co. , Tamshui, Taipei 251, Taiwan
Journal of Toxicologic Pathology 19 (suppl) 21-21, 2006.
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P-17 Miso (Japanese soybean paste) was protective against hypertension compared to same amount of sodium chloride diet in Dahl salt-sensitive rats
Hiromitsu WATANABE, Naoki KASHIMOTO, Jyunko KASHIWABARA, Kenji KAMIYA
Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Journal of Toxicologic Pathology 19 (suppl) 21-21, 2006.
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P-18 Comparison Between Focal Myocarditis/Myocardial Degeneration in Young Rats and Myocardial Fibrosis in Aged Rats
Atsushi KUMANO, Takeshi KANNO, Yumi WAKO, Takuya DOI, Yuki TOMONARI, Minoru TSUCHITANI
Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, 314-0255, Japan.
Journal of Toxicologic Pathology 19 (suppl) 22-22, 2006.
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P-19 Electron Microscopic Observation of Vascular Lesions at Meninx and Retina in Rat Treated with 3,3' -Iminodipropionitrile (IDPN)
Yuki TOMONARI, Kotaro YAMASHITA, Atsushi KUMANO, Hiroko KOKOSHIMA, Yumi WAKO, Minoru TSUCHITANI
Mitsubishi Chemical Safety Institute Ltd. , Ibaraki 314-0255, Japan.
Journal of Toxicologic Pathology 19 (suppl) 22-22, 2006.
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P-20 A Case of Acute Myeloid Leukemia in a Young Beagle Dog
Osamu SAWAMOTO, Sanae KISHIMOTO, Seiji SHINOHARA, Shinji ICHIKAWA
Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc. , Tokushima 772-8601, Japan
Journal of Toxicologic Pathology 19 (suppl) 23-23, 2006.
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P-21 Susceptibility of 4-Nitroquinoline 1-Oxide-induced Tongue Carcinogenesis in Human c-Ha-ras Proto-Oncogene Transgenic Rats
Takuji TANAKA1), Hiroyuki KOHNO1), Rikako SUZUKI1), Shigeyuki SUGIE1), Hiroyuki TSUDA2)
1)Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa 920-0293, Japan, aDepartment of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Aichi 467-8601, Japan
Journal of Toxicologic Pathology 19 (suppl) 23-23, 2006.
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P-22 Early Development of Multiple Colonic Neoplasms in Apcmw Mice That Received Dextran Sodium Sulfate
Rikako SUZUKI, Hiroyuki KOHNO, Shigeyuki SUGIE, Takuji TANAKA
Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa 920-0293, Japan
Journal of Toxicologic Pathology 19 (suppl) 24-24, 2006.
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P-23 Crypt fissioning: potential target of X-irradiation induced colonic tumorigenesis in Apc Mink mouse model
Tetsuya TSUKAMOTO, Akihiro HIRATA, Masae TATEMATSU
Div. Oncol. Pathol. , Aichi Cancer Center Res. Inst. , Nagoya, 464-8681 Japan
Journal of Toxicologic Pathology 19 (suppl) 24-24, 2006.
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P-24 Stomach Lesion in WTC Deafness Kyoto (dfk) Rat, a Potassium Channel Kcnq1 Mutant
Mitsuru KUWAMURA1), Ryoko OKAJIMA1), Jyoji YAMATEI1), Takao KOTAIVI1), Hiroshi GOHMA2), Takashi KURAMOTO2), Tadao SERIKAWA2)
1)Laboratory of Veterinary Pathology, Osaka Prefecture University, Sakai, Osaka 599-8531, 2)Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 25-25, 2006.
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P-25 Effects of a selective cyclooxygenase(COX)-2 inhibitor, etodolac, on proliferative changes of forestomach mucosa in alloxan-induced diabetic rats.
Tomoya SANO, Kiyokazu OZAKI, Tetsuro MATSUURA, Yasushi KODAMA, Isao NARAMA
Dep. Pathol. Fac. Pharm. Setsunan Univ. Osaka 573-0102, Japan.
Journal of Toxicologic Pathology 19 (suppl) 25-25, 2006.
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P-26 Periodontal Disease and Dental Caries in Alloxan-induced Diabetic Rats.
Yutaka NAKAHARA1), 2), Kiyokazu OZAKI1), Yoko FUKUZATO3), Tetsurou MATSUURA1), Isao NARAMA1)
1)Dep. Pathol. , Fac. Pharm. , Setsunan Univ. , Osaka 573-0101 Japan, 2)Panapharm Laboratories Co. , Ltd. , Kumamoto 869-0425 Japan, 3)Sunstar Inc. , Osaka 569-1195 Japan
Journal of Toxicologic Pathology 19 (suppl) 26-26, 2006.
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P-27 Chemopreventive and antioxidative effects of a tropical plant Azadirachta indica (Neem) on azoxymethane-induced rat colon carcinogenesis
Junya ARAKAKI1, 2, Masumi SUZUI1, Takamitsu MORIOKA1, Tatsuya KINJO1, 2, Tatsuya KANESHIRO1, Morihiko INAMINE1, Nao SUNAGAWA1, Tadashi NISHIMAKI2, Naoki YOSHIMI1.
1Tumor Pathol, 2Digest Gen Surge, Univ. Ryukyus Facult. Med. , Uehara Nishihara-cho, Okinawa 903-0215, Japan
Journal of Toxicologic Pathology 19 (suppl) 26-26, 2006.
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P-28 Promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and green tea extract after initiation with N-methyl-N'-nitrosoguanidine
Yuichi KUROIWA1), Yuji ISHII2), Takashi UMEMURA1), Keita KANKI1), Akiyoshi NISHIKAWA1), Hiroyuki NAKAZAWA2), Masao HIROSE1)
1)Divv of Path. , NIHS, Tokyo 158-8501, 2)Dep. of Analy. Chem. , Hoshi Univ, Tokyo 142-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 27-27, 2006.
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P-29 Lack of modifying effect of purple corn color in a rat medium-term colorectal carcinogenesis model
Yoshio OTA, Toshio IMAI, Young-Man CHO, Mai HASUMURA, Masao HIROSE
Div. Pathol. , Natl. Inst. Health Sci, Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 27-27, 2006.
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P-30 Carcinogenic susceptibility of p53 knockout mouse to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
Akihiro HIRATA1)2)3), Tetsuya TSUKAMOTO1), Shinji TAKASU1), 3), Masami YAMAMOTO1), Hiroki SAKAI3), Tokuma YANAI3), Toshiaki MASEGI3), Masae TATEMATSU1)
1)Div. Oncol. Pathol. , Aichi Cancer Ctr. Res. Inst. , Aichi, 464-8681, 2)Div. Animal Experiment, Life Sci. Res. Ctr. , Gifu Univ. , Gifu, 501-1194, 3)Div. Vet. Pathol. , Fac. Applied Biol. Sci. , Gifu Univ. , Gifu, 501-1193, Japan
Journal of Toxicologic Pathology 19 (suppl) 28-28, 2006.
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P-31 Susceptibilities to gastric carcinogenesis in three different mouse strains and chimeric mice treated with N-methyl-N-nitrosourea.
Masami YAMAMOTO1), Tetsuya TSUKAMOTO1), Akihiro HIRATA1)2), Hiroki SAKAI1)3), Shinji TAKASU1)3), Tokuma YANAI3), Toshiaki MASEGI3), Moriaki KUSAKABE4), Masae TATEMATSU1)
1)Div. Oncol. Pathol. , Aichi Cancer Ctr. Res. Inst. , Nagoya, 464-8681, 2)Div. Animal Eperiment, Life Sci. Res. Ctr. , Gifu Univ. , Gifu, 501-1194, 3)Dep. Vet. Pathol. , Gifu Univ. , Gifu, 501-1193, 4)ANB Tsukuba Institute, Aloka Co. , Ltd. , Kasumigaura, 300-0134, Japan
Journal of Toxicologic Pathology 19 (suppl) 28-28, 2006.
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P-32 Modifying effect of anti-inflammatory agents on colorectal carcinogenesis induced by DMH and DSS
Young-Man CHO, Toshio IMAI, Mai HASUMURA, Shigeaki TAKAMI, Masao HIROSE
Div. Pathol. , Natl. Inst. Health Sci. , Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 29-29, 2006.
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P-33 14-Week Oral Toxicity Study of Kava in F344 Rats: Immunohistochemical Analysis of Expression of Hepatic Cytochrome
Katsuhiko YOSHIZAWA1), Natasha CLAYTON2), Grace KISSLING2), Leo BURKA2), Po-Chuen CHAN2), Abraham NYSKA2)
1)Astellas Pharma Inc. , Osaka 532-8514, Japan, 2)National Institute of Environmental Health Sciences, NC 27709, USA
Journal of Toxicologic Pathology 19 (suppl) 29-29, 2006.
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P-34 Absence of B-catenin Aalteration in Hepatic Tumors Induced by p-Nitroanisole in Crj:BDF1 Mice
Masahiko KUSHIDA1), Sigetoshi AISO2), Keiichirou MORIMURA1), Min WEI1), Hideki WANIBUCHI1), Kasuke NAGANO2), Shoji FUKUSHIMA1)
1)Department of Pathology, Osaka City University Medical School, Osaka 545-8585, Japan, 2)Division of Pathology, Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Kanagawa 257-0015, Japan
Journal of Toxicologic Pathology 19 (suppl) 30-30, 2006.
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P-35 Expression of Notch-signaling related molecules in the liver of PCK rats, an animal model of Caroli's disease with congenital hepatic fibrosis
Shinichi FURUBO1, 2), Yusuke NOZAKI1, 2), Kenichi HARADA2), Mitsue YASOSHIMA2), Takahiro SANZEN1), Kazuo KIZAWA1), Yasuni NAKANUMA2)
1)Drug Safety Dep. , Toyama Chemical Co. , Ltd. , Toyama 930-8508, Japan, 2)Dep. Hum. Pathol. , Kanazawa Univ. Graduate School of Medicine, Kanazawa 920-8640, Japan.
Journal of Toxicologic Pathology 19 (suppl) 30-30, 2006.
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P-36 Modifying potential of dietary D-allose, a rare sugar, in a medium-term liver carcinogenesis bioassay in F344 male rats.
Masanao YOKOHIRA, Keiko YAMAKAWA, Kousuke SAOO, Yoko MATSUDA, Yu ZENG, Kyoko HOSOKAWA, Katsumi IMAIDA
Oncopathology, Fac. Med. , Kagawa Univ. , Kagawa 761-0793, Japan
Journal of Toxicologic Pathology 19 (suppl) 31-31, 2006.
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P-37 In vitro Genotoxic potential and liver initiation activity of pipemidic acid
Tadashi ITOH, Yu F. SASAKI, Satomi KAWAGUCHI, Hiroki SAKAI, Kunitoshi MITSUMORI
Lab. Vet. Pathol, Fac. Agri. , Tokyo Univ. Agri. and Tech. , Tokyo 183-8509, Japan
Journal of Toxicologic Pathology 19 (suppl) 31-31, 2006.
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P-38 A Novel Marker Characterizing Preneoplastic and Neoplastic Rat Liver Lesions Negative for Glutathione S-transferase placental
Tokuo SUKATAI1), 2), Satoshi UWAGAWA1), 2), Keisuke OZAKI1), 2), Masahiko KUSHIDA1), 2), Keiichirou MORIMURA2), Hideki WANIBUCHI2), Shoji FUKUSHIMA2)
1)The Environmental Health Science Lab. , Sumitomo Chemical Co. , Ltd. , Osaka 554-8558, 2)Ihe Department of Pathology, Osaka City Univ. Medical School, Osaka 545-8585, Japan
Journal of Toxicologic Pathology 19 (suppl) 32-32, 2006.
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P-39 Preliminary evaluation of effects of copper gluconate in rats given multiple carcinogens
Masayoshi Abe1), 2), Noriko Suzuki2), Midori Yoshida2), Maki Igarashi2), Koji Usuda1), Satoshi Furukawa1), Fumiyuki Uematsu2), Masakazu Takahashi2), Akihiko Maekawa3), Dai Nakae2)
1)Bio. Res. Lab. , Nissan Chem. Ltd. , Saitama 349-0294, Japan, 2)Department of Pathology and 3birector, Sasaki Institute, Tokyo 101-0062, Japan
Journal of Toxicologic Pathology 19 (suppl) 32-32, 2006.
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P-40 Lack of modifying Effects of Propolis on Hepatocarcinogenesis in a Rat Medium-term Liver. Bioassay
Min WEI, Hideki WANIBUCHI, Takayuki YUNOKI, Jin Seok KANG, Rawiwan PUATANACHOKCHAI, Shoji FUKUSHIMA
Department of Pathology, Osaka City University Medical School, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan
Journal of Toxicologic Pathology 19 (suppl) 33-33, 2006.
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P-41 No promoting effect of BCAA( branched amino acid) on rat hepatocarcinogenesis
Takayuki YUNOKI, Hideki Wanibuti, Toshio ICHIHARA, Masahiko KUSHIDA, Yoshiaki KAWADA, Shoji FUKUSHIMA
Department of Pathology, Osaka city University Medical School, Osaka 545-8585, Japan
Journal of Toxicologic Pathology 19 (suppl) 33-33, 2006.
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P-42 Gene Expression Analysis Associated with Malignant Progression in Rat Hepatocellular Carcinogenesis.
Shugo Suzuki, Kentaro Takeshita, Makoto Asamoto, Satoru Takahashi, Tomoyuki Shirai
Dept. of Exp. Pathol. and Tumor Biol. , Nagoya City Univ. Grad. Sch. of Med. Sci. , Nagoya 467-8601, JAPAN
Journal of Toxicologic Pathology 19 (suppl) 34-34, 2006.
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P-43 Effect of kojic acid on diethylnitrosamineinduced rat hepatocarcinogenesis using medium-term bioassay.
Yaowares CHUSIRI, Rawiwan PUATANACHOKECHAI, Anna KINOSHITA, Min WEI, Hideki WANIBUCHI, Shoji FUKUSHIMA
Dept. Pathol, Osaka City Med Univ. 545-8585, Japan.
Journal of Toxicologic Pathology 19 (suppl) 34-34, 2006.
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P-44 Effect of a-benzene hexachioride on diethyl nitrosamine-induced hepatocarcinogenesis in TGF-a transgenic mice
Rawiwan PUATANACHOKCHAI, Hideki WANIBUCHI, Min WEI, Jin Seok KANG, Yaowares CHUSIRI, Anna KINOSHITA, Shoji FUKUSHIMA
Dept. Pathol, Osaka City Med Univ. 545-8585, Japan.
Journal of Toxicologic Pathology 19 (suppl) 35-35, 2006.
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P-45 Histopathological examination of the liver in mice fed with high fat diet
Shigeharu TSUJIOKA, Makoto ITO, Akira GOMORI, Akane ISHIHARA, Hisashi IWAASA, Jun SUZUKI, Minoru SASAKI, Akira KANATANI, Keiji SAMURA, Masaru NISIKIBE
Banyu Pharmaceutical Co. Ltd. , Ibaraki, 300-2611, Japan
Journal of Toxicologic Pathology 19 (suppl) 35-35, 2006.
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P-46 Retrospective evaluations of fenofibrate focusing on a prediction of MTD and hepatocarcinogenesis
Masatoshi TAKAHASHI, Takao WATANABE, Tomohide Akiba
Fuji Research Laboratories, Kowa Co. , Ltd. , Shizuoka 417-8650, Japan
Journal of Toxicologic Pathology 19 (suppl) 36-36, 2006.
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P-47 Gene expression profiling specific to the tumor promotion process of rat hepatocarcinogenesis induced by fenbendazole
Gye-Hyeong WOO1), Makoto SHIBUTANI1), Kaoru INOUE1), Mami U1), Keiko KUROIWA1), Katsuhide IGARASHI2), Hitoshi FUJIMOTO1), Masao HIROSE1)
1)Division of Pathology, Natl Institute of Health Sciences, Tokyo 158-8501, Japan, 2)Division of Molecular Toxicology, Natl Institute of Health Sciences, Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 36-36, 2006.
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P-48 Vacuolation of Sinusoidal Cell in Liver of Cynomolgus Monkeys
Junko FUJISHIMA, Tomohiro FURUKAWA, Xiuying YANG, Kimiaki HIRAKAWA, Shigeru SATAKE, Takaharu NAGAOKA, Yasuhiro KAMIMURA, Yuki KUWAMURA, Yutaka CHIHAYA, Hiroshi TOKADO, Hiroaki MIYAJIMA
Shin Nippon Biomedical Laboratories, Ltd. Kagoshima, 891-1394, Japan
Journal of Toxicologic Pathology 19 (suppl) 37-37, 2006.
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P-49 In Vlvo Mutation Analysis of Liver DNA In p53+/-lgpt Delta Transgenic Mice Treated With Acrolein
Keita KANKI1), Akiyoshi NISHIKAWA1), Takashi UMEMURA1), Ken-ichi MASUMURA2), Yuji ISHII1), Yuichi KUROIWA1), Yukio KODAMA3), Takehiko NOHMI2), Masao HIROSE1)
1)Div. Pathol., 2)Div. Genet. Mutagen., 3)Div. Toxicol. , Natl. Inst. Health Sci. , Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 37-37, 2006.
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P-50 Examinations on the difference of hepatocarcinogenic susceptibility between C3H/He sub-strains using the two-stage hepatocarcinogenesls model.
Hisayoshi TAKAGI1), Masaki MATSUI1), Natsuyo ANDO1), Noriko SATO1), Kunitoshi MITSUMORI2)
1)Bio Technical Center, Japan SLC Inc. , Shizuoka 433-8114, 2)Lab. Vet. Pathol. , Tokyo Univ. Agricul. and Techol. , Tokyo 183-8509, Japan
Journal of Toxicologic Pathology 19 (suppl) 38-38, 2006.
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P-51 Toxicogenomic Approach for Early Assessment of Potential Hepatocarcinogenicity of Chemicals in Rats
Takeki UEHARA, Mitsuhiro HIRODE, Atsushi ONO, Tetsurou URUSHIDANI, Toshikazu MIYAGISHIMA, Taku NAGAO
Toxicogenomics Project, National Institute of Biomedical Innovation, Osaka, 567-0085, Japan.
Journal of Toxicologic Pathology 19 (suppl) 38-38, 2006.
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P-52 Gene Expression Profiling in Rat Liver Treated with Ethionine - Relationship of Hepatotoxicity and Coagulopathy
Mitsuhiro HIRODE, Takeki UEHARA, Atsushi ONO, Tetsurou URUSHIDANI, Toshikazu MIYAGISHIMA, Taku NAGAO
Toxicogenomics Project, National Institute of Biomedical Innovation, Osaka, 567-0085, Japan.
Journal of Toxicologic Pathology 19 (suppl) 39-39, 2006.
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P-53 Kidney Tumors in Rats Fed 2,4-Dichloro-1-nitrobenzene-containing Diet for Two Years
Hideki SENOH, Yumi UMEDA, Taku KATAGIRI, Shigetoshi AISO, Kasuke NAGANO
Japan Bioassay Research Center, Kanagawa 257-0015, Japan
Journal of Toxicologic Pathology 19 (suppl) 39-39, 2006.
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P-54 Mouse Strain Differences in Sensitivity to the Promoting Effect of Sodium L-Ascorbate in a Two-stage Urinary Bladder Carcinogenesis
Takashi MURAI1, 2), Koichi MASUNO1), Kae IMURA1), Noriko TSUCHIYA1), Satoru MORN, Keiichirou MORIMURA2), Hideki WANIBUCHI2), Shoji FUKUSHIMA2)
1)Developmental Research Laboratories Shionogi & Co. , Ltd. , Osaka 561-0825, 2)First Department of Pathology Osaka City University Medical School, Osaka 545-8585, Japan
Journal of Toxicologic Pathology 19 (suppl) 40-40, 2006.
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P-55 Risk assessment of chromated copper arsenate (CCA) used as a wood preservative: I. Effects of repeated oral administration on rats
Nobuaki NAKASHIMA, Hisao KAWAKATSU, Sayuri KOJIMA, Makio TAKEDA, Akiko ENOMOTO, Maki KUWAHARA, Yukiko TAKEUCHI, Naofumi TAKAHASHI, Takanori HARADA
The Institute of Environmental Toxicology, Ibaraki 303-0043, Japan
Journal of Toxicologic Pathology 19 (suppl) 40-40, 2006.
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P-56 In vivo mutagenicity and initiation following overexpression of OGG1 and increase of 8-hydroxyguanine formation in the kidneys of rats given potassium bromate.
Takashi UMEMURA1), Keita KANKI1), Yuichi KUROIWA1), Yuji ISHII1), Keita OKANO1), Takehiko NOHMI3), Akiyoshi NISHIKAWA1), Masao HIROSE1)
1Div of Path., 3Div of Gene. Muta. , NIHS, Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 41-41, 2006.
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P-57 Carcinogenicity and In vivo mutagenicity of potassium bromate in Big Blue rat
Takashi YAMAGUCHI, Min WEI, Masako OMORI, Hideki WANIBUCHI, Shoji FUKUSHIMA
Dept. Pathol, Osaka City Med Univ. 545-8585, Japan.
Journal of Toxicologic Pathology 19 (suppl) 41-41, 2006.
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P-58 Analysis of Involvement of oxidative stress on the renal carcinogenesis Induced by madder color In F344 rats
Kaoru INOUE1), Makoto SHIBUTANI1), Gye-Hyong WOO1), Mami U1), Katsuhide IGARASHI2), Keiko KUROIWA1), Hitoshi FUJIMOTO1), Masao HIROSE1)
1)Div. Pathol., 2)Div. Mol. Toxicol. , Natl. Inst. Health Sci. , Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 42-42, 2006.
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P-59 Urinary metabonomics analysis in amiodarone-induced phospholipidosis of rat by FT-ICR-MS
Mina HASEGAWA, Yoko HASEGAWA, Shigeo TAKENAKA, Mitsuru KUWAMURA, Shingo TSUYAMA
Department of Veterinary Sciences, Osaka Prefecture University Sakai, Osaka 599-8531, Japan
Journal of Toxicologic Pathology 19 (suppl) 42-42, 2006.
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P-60 HISTOLOGICAL INVESTIGATION OF PROLIFERATIVE TUBULE PROFILES OCCURRING IN ADVANCED CHRONIC PROGRESSIVE NEPHROPATHY (CPN) IN THE FISCHER 344 RAT
John Curtis Seely1, Gordon C. Hard2
1Experimental Pathology Laboratories, Inc. , Research Triangle Park, NC, 2Consultant, National Toxicology Program Archives, Research Triangle Park, NC
Journal of Toxicologic Pathology 19 (suppl) 43-43, 2006.
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P-61 Toxicity of di(2-ethylhexyl)phthalate (DEHP) and di(2-ethylhexyl)adipate (DEHA) under conditions of renal dysfunction induced by folic acid in rats
Kyoko NABAE1), Yuko DOI1, 2), Satoru Takahashi2), Toshio ICHIHARA1, 2), Seiko TAMANO1), Tomoyuki SHIRAI2)
1)DIMS Institute of Medical Science, Inc. , Ichinomiya 491-0113, 2)Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences. , Nagoya 467-8503, Japan
Journal of Toxicologic Pathology 19 (suppl) 43-43, 2006.
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P-62 The effects of 3,3'-iminodipropionitrile (IDPN) on the male rat testis
Akiko NAKAZAWA1), Atsuko YUASA1), Hiroshi ABE2), Chihaya KAKINUMA1)2), Kaoru TERASHIMA1)
1)Material Safety Test Center, Fuji Photo Film Co. , LTD. , Kanagawa 250-0193, Japan, 2)Department of Pathology, Juntendo University, School of Medicine, 11 3-8421, Japan
Journal of Toxicologic Pathology 19 (suppl) 44-44, 2006.
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P-63 Molecular Pathway in Germ Cell Apoptosis Induced Sertoli Cell Damage from Administration of mono-(2-ethylhexyl) phthalate.
Masaki YAMAZAKI1), 2), Miwa OKAMURA1), Mitsuyoshi MOTO1), Masako MUGURUMA1), Yoko KASHIDA3), Masami SUZUKI2), Kunitoshi MITSUMORI1)
1)Lab. Vet. Pathol, Fac. Agri. , Tokyo Univ. Agri. and Tech. , Tokyo, 183-8509, Japan, 2)Safety Assessment Dept. , Chugai Pharmaceutical Co. , LTD. , Shizuoka, 412-8513, Japan, 3)Div. Medicinal Chemistry & Pharmacognosy, Ohio State University, Ohio, 43210, USA
Journal of Toxicologic Pathology 19 (suppl) 44-44, 2006.
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P-64 Inhibitory Effects of Citrus Nobiletin and Auraptene on Prostate Carcinogenesis in Transgenic Rats Developing Adenocarcinoma of the Prostate (TRAP)
Ming Xi TANG1), Kumiko OGAWA1), Makoto ASAMOTO1), Naomi HOKAIWADO1), Azman SEEN1), Shugo SUZUKI1), Satoru TAKAHASHI1), Takuji TANAKA2), Tomoyuki SHIRAI1)
1)Dept. of Exp. Pathol. and Tumor Biol. , Nagoya City Univ. Grad. Sch. of Med. Sci. , Nagoya 467-8601, 2)Dept. of Oncol. Pathol. , Kanazawa Med. Univ. , Ishikawa 920-0293, Japan
Journal of Toxicologic Pathology 19 (suppl) 45-45, 2006.
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P-65 Development of mammary glands of female SD rat with neonatal administration of estrogen.-; particularly; a gene expression of a terminal end buds (TEBs) cell; -
Masakazu SOUDA, Hiroaki KAWAGUCHI, Hideo KAWASHIMA, Takao HORI, Mamoru FUNATO, Tsuyoshi YOSHIKAWA, Yoshihisa UMEKITA, Hiroshi YOSHIDA
The department of tumor pathology, graduate school of medical and dental science, kagoshima university, 8-35-1 sakuragaoka, kagoshima 890-8544, japan.
Journal of Toxicologic Pathology 19 (suppl) 45-45, 2006.
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P-66 Induction of Mammary carcinoma (MC) and Mammary dysplasia (MD) Following Multiple administration of various deses of 7,12-dimethylbenz[a]anthracene (DMBA) to female SD rats for a Prolonged Period
Takao HORI1), 2), Hiroaki KAWAGUCHI1), Shuhei TAGUCHI1), Mamoru FUNATO1), 2), Tsuyoshi YOSHIKAWA1), 2), Masakazu SOUDA1), Takuro KODAMA1), Takaharu NAGAOKA1), 2), Hiroki YOSHIDA1)
1)Kagoshima Univ. Kagoshima 890-8544, Japan, 2)Shin Nippon Biomedical Laboratories, Ltd. Kagoshima 891-1394, Japan
Journal of Toxicologic Pathology 19 (suppl) 46-46, 2006.
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P-67 Inhibitory effect of antioxidants on mammary carcinogenesis in rats initiated with N-methyl-N-nitrosourea followed by acrylamide treatment
Shigeaki TAKAMI, Toshio IMAI, Mai HASUMURA, Young-Man CHO, Masao HIROSE
Div. Pathol. , Natl. Inst. Health Sci. , Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 46-46, 2006.
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P-68 Immunohistochemical evaluation of spontaneous mammary adenocarcinoma in female CD(SD)IGS rats: correlation between expression of matrix metalloproteinase and lung metastasis
Yuzo YASUI, Kayoko NAGAI, Ryo YAMASHITA, Mayumi ISHIZAKI, Toko OHIRA, Tohru KIHARA, Kazushige HASEGAWA, Masayo HOSOI, Rumiko MIYAJIMA, Atsushi SHIGA, Hijiri IWATA, Kiyoshi IMAI
Pathology Department, An-pyo Center, Shizuoka 437-1213, Japan
Journal of Toxicologic Pathology 19 (suppl) 47-47, 2006.
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P-69 Ectopic Uterine Ovarian Tissue in Cynomolgus Monkeys
Yuki KUWAMURA, Kimiyo KAKEHI, Youhei TANIGAWA, Yasuhiro KAMIMURA, Junko FUJISHIMA, Tomohiro FURUKAWA, Kimiaki HIRAKAWA, Hiroaki MIYAJIMA
Pathology Center, Pathology Department, Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, LTD. Osaka 541-0044, Japan
Journal of Toxicologic Pathology 19 (suppl) 47-47, 2006.
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Immunohistochemical analysis of 6-catenin, p53, Pten, ERα and cyclin D1 in Crj: F344 rat endometrial cell adenocarcinomas
Mari IIDA, Hijiri IWATA, Kiyoshi IMAI
An-pyo Center, Shizuoka, 437-1213, Japan
Journal of Toxicologic Pathology 19 (suppl) 48-48, 2006.
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P-71 Immunopathological analysis of Inflamed thyroid capsular lesion of rats initiated with N-bis(2-hydroxypropyl)nitrosamine followed by sulfadimethoxine treatment
Mai HASUMURA1), Toshio IMAI1), Yoshio OTA1), Shigeaki TAKAMI1), Young-Man CHO1), Akiko HACHISUKA2), Reiko TESHIMA2), Masao HIROSE1)
1)Div. Pathol., 2)Div. Biochem. Immunochem. , Natl. Inst. Health Sci. , Tokyo 158-8501, Japan.
Journal of Toxicologic Pathology 19 (suppl) 48-48, 2006.
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P-72 Histochemical and cytochemical approach to vacuolar change in the thyroid follicular cells in BrlHan:WIST@Jcl (GALAS) rat and the relation to thyroglobulin synthesis
Yoshiaki SAITO, Kenji USUMI, Makiko KUWAGATA, Kazunori KONNO, Kazumi TAGO, Hiromasa TAKASHIMA, Tomoko NAGATA
Hatano Research Institute, Food and Drug Safety Center, Kanagawa 257-8523, Japan
Journal of Toxicologic Pathology 19 (suppl) 49-49, 2006.
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P-73 Age- and sex-related differences in spontaneous hemorrhage and fibrosis of the pancreatic islets in Sprague-Dawley rats
Masako IMAOKA, Mayumi GOTO, Satoko TAGO, Takashi AOKI, Toshiya TS UCHIYA, Takami SUZUKI, Kosuke NOZAKI, Hiroshi SATOH, Kazuhisa FURUHAMA
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co. , Ltd. , 1-16-13 Kitakasai, E dog awa-ku, Tokyo 134-8630, Japan
Journal of Toxicologic Pathology 19 (suppl) 49-49, 2006.
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P-74 Modifying effect of indomethacin and nimesulide on rat thyroid carcinogenesis iuduced by N-bis(2-hydroxypropyl)nitrosamine and sulfadimethoxine treatment
Toshio IMAI, Yoshio OTA, Mai HASUMURA, Shigeaki TAKAMI, Young-Man CHO, Masao HIROSE
Div. Pathol. , Natl. Inst. Health Sci. , Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 50-50, 2006.
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P-75 Ductal Origin of Pancreatic Adenocarcinomas Induced by Conditional Activation of a Human Ha-ras Oncogene in Rat Pancreas
Katsumi FUKAMACHI, Yutaka OHSHIMA, David B. ALEXANDER, Shinobu UEDA, Hiroyuki TSUDA
Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Aichi 467-8601, Japan
Journal of Toxicologic Pathology 19 (suppl) 50-50, 2006.
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P-76 VEGF Expression in Estrogen-induced Rat Pituitary Prolactin-producing Tumor (Prolactinoma): Its Suggestive Roles in Angiogenesis during Pituitary Tumorigenesis
Katsuhiro MIYAJIMA1, 2, Susumu TAKEKOSHI2, Kochi KAKIMOTO1, 2, Takeo MINEMATSU2, Hanako KAJIYA2, Noboru EGASHIRA2, Toshiyuki SHODA1, Toshiki IWASAKA1, Akemi TAKAHASHI1, Haruko KOIZUMI1, Yoshifumi MIYAKAWA1, Robert Yoshiyuki OSAMURA2
1Central Pharmaceutical Research Institute, JAPAN TOBACCO INC. , Kanagawa 257-0024, 2Dept. Pathol, Tokai Univ. School of Medicine, Kanagawa 259-1193, Japan
Journal of Toxicologic Pathology 19 (suppl) 51-51, 2006.
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P-77 Palmar-Plantar Erythrodysesthesia Like Cutaneous Lesions Induced by Intermittent Intravenous Injections of Doxil, a Pegylated Liposomal Doxorubicin, in Nude Mice
Kiyonori KAI, Takami SUZUKI, Toshiya TSUCHIYA, Tesuyo KAJIMURA, Kazuhisa FURUHAMA
Drug Safety Research Laboratory, Daiichi Pharmaceutical Co. , Ltd. , Edogawa-ku, Tokyo 134-8630, Japan
Journal of Toxicologic Pathology 19 (suppl) 51-51, 2006.
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P-78 Effects of Parathyroid Hormone on Osteopenia in Iron Lactate-Overloaded Rats
Shuuichi MATSUSHIMA1, 2), Noriko TSUCHIYA1), Kae IMURA1), Koichi MASUNO1), Mikinori TORII1), Kiyokazu OZAKI2), Isao NARAMA2), Takao KOTANI3)
1)Pathobgy Section, Drug Safety Evaluation, Developmental Research Laboratories, Shionogi & Co. , Ltd. , 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan, 2)Department of Pathology, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka 573-0101, Japan, 3)Department of Veterinary Pathology, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Gakuencho 1-1, Sakai, Osaka 599-8531, Japan
Journal of Toxicologic Pathology 19 (suppl) 52-52, 2006.
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P-79 Enhancing effects of chromated copper arsenate (CCA) used as a wood preservative on the skin carcinogenesis induced by ultraviolet B (UVB) radiation
Naofumi TAKAHASHI, Katsumi ISHIZUKA, Hisao KAWAKATSU, Tadashi KOSAKA, Satoru YAMAGUCHI, Ryoichi OHTSUKA, Makio TAKEDA, Yukiko TAKEUCHI, Maki KUWAHARA, Akiko ENOMOTO, Nobuaki NAKASHIMA, Takanori HARADA
The Institute of Environmental Toxicology, Ibaraki 303-0043, Japan
Journal of Toxicologic Pathology 19 (suppl) 52-52, 2006.
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P-80 Case Report of a Spontaneous Undifferentiated Tumor Noted in Young Male Mouse
Mika NAGAIKE, Masanao NOMURA, Kosei INUI, Kimie SAKAI, Masashi IMAMURA, Shuichi YOTSUYA
Central Research Institute, Ishihara Sangyo Kaisha, Ltd. , Nishishibukawa 2-3-1, Kusatsu-shi, Shiga 525-0025, Japan
Journal of Toxicologic Pathology 19 (suppl) 53-53, 2006.
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P-81 Comparison of detective power of parameters for immunotoxicity in a 28-day repeat-dose toxicity study in rats
Etsuko OHTA, Yukio FUJIMAKI, Ai MINAKAWA, Toshiyuki TSUCHIYA, Minoru SASAKI, Keiji SAMURA, Masaru NISIKIBE
Tsukuba Safety Assessment Laboratories, Banyu Pharmaceutical Co. Ltd. , Ibaraki, 300-2611, Japan
Journal of Toxicologic Pathology 19 (suppl) 53-53, 2006.
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P-82 Effects of Lipopolysaccharide on Immune System in Rats
Yoshihumi Kaneko, Sumihisa Sueyoshi, Yasukazu Sato, Hirofumi Tanase, Shogo Iwasaki, Harumi Kamiyama, Makiko Takahashi, Masakazu Yamasaki, Yoshihiro Masumoto, Kiyoyuki Tsuru
Kyorin pharmaceutical Co. , Ltd. , Tochigi 329-0114, Japan
Journal of Toxicologic Pathology 19 (suppl) 54-54, 2006.
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P-83 Effectiveness of Heat-induced Antigen Retrieval on Immunocytochemistry and Dot-blot Analysis using MCF-7 Brest Cancer Cells and Anti-Estrogen Receptor Antibodies recognized Various Regions of Antigen
Kochi KAKIMOTO1, 2), Katsuhiro MIYAJIMA1, 2), Susumu TAKEKOSHI2), Toshiyuki SHODA1), Toshiki IWASAKA1), Haruko KOIZUMI1), Yoshifumi MIYAKAWA1), Robert Yoshiyuki OSAMURA2)
1)Central Pharmaceutical Research Institute, Japan Tobacco Inc. , Kanagawa 257-0024, 2)Dept. Pathol, Tokai Univ. School of Medicine, Kanagawa 259-1193, Japan
Journal of Toxicologic Pathology 19 (suppl) 54-54, 2006.
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P-84 Immnohistochemical Evaluation of Podoplanin in Rat Various Tissues
Kayoko NAGAI, Ryo YAMASHITA, Mayumi ISHIZAKI, Toko OHIRA, Yuzo YASUI, Tohru KIHARA, Kazushige HASEGAWA, Masayo HOSOI, Rumiko MIYAJIMA, Atsushi SHIGA, Hijiri IWATA, Kiyoshi IMAI
Department of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides, Shizuoka, 437-1213, Japan.
Journal of Toxicologic Pathology 19 (suppl) 55-55, 2006.
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P-85 Atelia with Gelatinous Degeneration of Bone Marrow in a Laboratory Cynomolgus Monkey
Yuichi MURAKAMI, Yoshimasa OKAZAKI, Masahiro MATSUMOTO, Shunji NAKATSUJI, Shiro FUJIHIRA, Katsuhiko YOSHIZAWA, Hisashi IKEGAMI, Kenjiro TSUBOTA, Yuji OISHI
Drug Safety Research Labs. , Astellas Pharma Inc. , Osaka 532-8514, Japan
Journal of Toxicologic Pathology 19 (suppl) 55-55, 2006.
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P-86 A case of congenital hepatic arteriovenous fistulae in a young beagle dog
Shinichiro IKEZAKI, Kenichiro KASAHARA, Mariko NAGATANI, Seiki YAMAKAWA, Ami AOKI, Kayoko KUDO, Toru HOSHIYA, Kazutoshi TAMURA
Bozo Research Center Inc. , Shizuoka 419-0101, Japan
Journal of Toxicologic Pathology 19 (suppl) 56-56, 2006.
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P-87 A malignant teratoma of the thyroid gland in a young Sprague-Dawley rat
Izumi MATSUMOTO1), Kazuo OKIMOTO1), Takatoshi KOUJITANI1), Kaoru TOYOSAWA1), Mami KOUCHI1), Katsushi MURAKAMI2), Yoshimi KONYA2), Kohji TANAKA1)
1)Dainippon Sumitomo Pharma Co. , Ltd. Osaka 564-0053, 2)KAC Co. , Ltd. 604-8423, Kyoto, Japan
Journal of Toxicologic Pathology 19 (suppl) 56-56, 2006.
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P-88 Spontaneous Yolk Sac Carcinoma Metastasizing to the Heart and Lung in a 10-week-old Female Sprague-Dawley rat
Satoru KAJIKAWA, Ayano TAKEUCHI, Katsuhisa SHIRAKI, Kenji NAKANO, Nobuyuki IZUMISAWA, Yuji OISHI
Drug Safety Research Labs. , Astellas Pharma Inc. , Tokyo 174-8511, Japan
Journal of Toxicologic Pathology 19 (suppl) 57-57, 2006.
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P-89 A Case: Report of Non-viral Cytoplasmic Inclusion Body in Hepatocytes of a Cynomolgus Monkey
Hisashi IKEGAMI, Yoshimasa OKAZAKI, Masahiro MATSUMOTO, Shunji NAKATSUJI, Shiro FUJIHIRA, Katsuhiko YOSHIZAWA, Kenjiro TSUBOTA, Yuichi MURAKAMI, Yuji OISHI
Dept. Toxicol. Pathol. , Drug Safety Research Labs. , Astellas Pharma Inc. , Osaka 532-8514, Japan.
Journal of Toxicologic Pathology 19 (suppl) 57-57, 2006.
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P-90 Hepatic lesion with granular degeneration/fatty change of hepatocytes and pericellular fibrosis in a C57BLI J mouse
Masako NAKANISHI1), Mitsuru KUWAMURA2), Midori YOSHIDA3), Akihiko MAEKAWA3), Hitoshi NAKAGAMA1)
1)Biochemistry Div. , Natl. Cancer Ctr. Res. Inst. , Tokyo 104-0045, 2)Lab. Vet. Pathol. , Osaka Pref. Univ, Osaka 599-8531, 3)Dep. Pathol. , Sasaki Inst. , Tokyo 101-0062, Japan
Journal of Toxicologic Pathology 19 (suppl) 58-58, 2006.
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P-91 Morphological Characteristics of Organs Without the Endocrine Systems in Wistar Hannover GALAS Rats Showing Spontaneous Dwarfs
Hiroko KOKOSHIMA, Takuya DOI, Tetsuro KUROTAKI, Junko SATO, Yuri KOTANI, Minoru TSUCHITANI
Mitsubishi Chemical Safety Institute Ltd. , Ibaraki, 314-0255, Japan.
Journal of Toxicologic Pathology 19 (suppl) 58-58, 2006.
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P-92 A case report of a spontaneous gastrointestinal stromal tumor (GIST) occurring in a F344 rat in a two-year carcinogenicity study
Hitoshi FUJIMOTO, Makoto SHIBUTANI, Keiko KUROIWA, Kaoru INOUE, Gye-Hyeong WOO, Mami U, Masao HIROSE
Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 59-59, 2006.
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P-93 Differences in gene expression profiles in the liver between carcinogenic and non-carcinogenic isomers of compounds given to rats in a 28-day repeat-dose toxicity study
Koji NAKAYAMA1), Yuuki KAWAKAMI1), Yukiko KAWANO1), Norichika MORIWAKI1), Masaru SEKIJIMA1), Masanori OTSUKA2), Yoshikuni YAKABE2), Hideki MIYAURA2), Koichi SAITO3), Kayo SUMIDA3), Tomoyuki SHIRAI4)
1)Mitsubishi Chemical Safety Institute Ltd. , Ibaraki 314-0255, 2)Chemical Evaluation and Research Institute, Tokyo 112-0004, 3)Sumitomo Chemical Co. , Ltd. , Osaka 554-8558, 4)Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Journal of Toxicologic Pathology 19 (suppl) 59-59, 2006.
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P-94 Global analysis of gene expression in MelQx-induced rat hepatocarcinogenesis
Jin Seok KANG, Hideki WANIBUCHI, Keiichirou MORIMURA, Anna KINOSHITA, Shoji FUKUSHIMA
Department of Pathology, Osaka City University Medical School, Osaka 545-8585, Japan
Journal of Toxicologic Pathology 19 (suppl) 60-60, 2006.
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P-95 Development of prediction method of carcinogenicity by characteristic gene expression profiles of mutagenic and non-mutagenic carcinogens.
Hiroshi MATSUMOTO1), Yoshikuni YAKABE1), Masanori OTSUKA1), Yasushi MINOBE1), Hideki MIYAURA1), Fumiyo SAITO1), Koichi SAITO2), Kayo SUMIDA2), Masaru SEKIJIMA3), Koji NAKAYAMA3), Makoto ASAMOTO4), Tomoyuki SHIRAI4)
1)Chemicals Evaluation and Research Institute, Tokyo 112-0004, Japan, 2)Sumitomo Chemical Co. , Ltd. , Osaka 554-8558, Japan, 3)Mitsubishi Chemical Safety Institute Ltd. , Ibaraki 314-0255, Japan, 4)Graduate School of Medical Sciences, Nagoya City Univ. , Nagoya 467-8601 , Japan
Journal of Toxicologic Pathology 19 (suppl) 60-60, 2006.
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P-96 Gene expression profiling specific to the tumor promotion by phenobarbital in the rat two-stage hepatocarcinogenesis
Makoto SHIBUTANI1), Gye-Hyeong WOO1), Kaoru INOUE1), Mami U1), Katsuhide IGARASHI2), Hitoshi FUJIMOTO1), Masao HIROSE1)
1)Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan, 2)Division of Molecular Toxicology, National Institute of Health Sciences, Tokyo 158-8501, Japan
Journal of Toxicologic Pathology 19 (suppl) 61-61, 2006.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-97 Development of the mouse microarray system targeting DNA methylation
Mami U1), Makoto SHIBUTANI1), Natusmi KATO1), Kaoru INOUE1), Gye-Hyeong WOO1), Tomoshi KAKEYA2), Hitoshi FUJIMOTO1), Masao HIROSE1)
1)Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan, 2)SCRUM Inc. , Tokyo 130-0021, Japan
Journal of Toxicologic Pathology 19 (suppl) 61-61, 2006.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-98 Pathological analysis of high-fat diet-induced obesity in C57BL/6J and BALB/cA mice
Satomi NISHIKAWA, Koji UETSUKA, Akira YASOSHIMA, Hiroyuki NAKAYAMA, Kunio DOI
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan
Journal of Toxicologic Pathology 19 (suppl) 62-62, 2006.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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P-99 Histomorphometry of adipose tissues using an image analysis system, Cellenger(R)
Yuji OKAMOTO, Hiroyuki HIGASHIYAMA, Hiroki INOUE, Masahiro KANEMASTU, Hiroshi KUSHIDA, Mine KINOSHITA, Satoshi ASANO
Pharmacology Department, Tsukuba Research Laboratories, GlaxoSmithKline K. K. , Ibaraki 300-4247, Japan
Journal of Toxicologic Pathology 19 (suppl) 62-62, 2006.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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