Journal of Toxicologic Pathology 23巻 4号

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Successful Drug Development Despite Adverse Preclinical Findings Part 1: Processes to Address Issues and Most Important Findings

Robert A. Ettlin1, Junji Kuroda2, Stephanie Plassmann3, David E. Prentice3
1Ettlin Consulting Ltd., 2KISSEI Pharmaceutical Co., Ltd., 3PreClinical Safety (PCS) Consultants Ltd.
Journal of Toxicologic Pathology 23 (4) 189-211, 2010.

Successful Drug Development Despite Adverse Preclinical Findings Part 2: Examples

Robert A. Ettlin1, Junji Kuroda2, Stephanie Plassmann3, Makoto Hayashi4, David E. Prentice3
1Ettlin Consulting Ltd., 2KISSEI Pharmaceutical Co., Ltd., 3PreClinical Safety (PCS) Consultants Ltd., 4Biosafety Research Center, Foods, Drugs, and Pesticides (BSRC)
Journal of Toxicologic Pathology 23 (4) 213-234, 2010.

Heat Stress in Rat Adriamycin Cardiomyopathy: Heat Shock Protein 25 and Myosin Accumulation

Mirian Strauss1, Alegna Rada1, Felix Tejero2, Tomas Hermoso3
1Seccion de Biologia Celular, Instituto de Medicina Tropical, Facultad de Medicina Universidad Central de Venezuela, 2Instituto de Zoologia y Ecologia Tropical, Facultad de Ciencias. Universidad Central de Venezuela, 3Seccion de Bioquimica de Parasitos, Instituto de Medicina Tropical, Facultad de Medicina, Universidad Central de Venezuela
Journal of Toxicologic Pathology 23 (4) 235-243, 2010.

Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats

Yoshiyuki Tago, Min Wei, Naomi Ishii, Anna Kakehashi, Hideki Wanibuchi
Department of Pathology, Osaka City University Medical School
Journal of Toxicologic Pathology 23 (4) 245-251, 2010.

Study on the Pathogenesis of Foreign Body Granulomatous Inflammation in the Livers of Sprague-Dawley Rats

Atsushi Shiga, Yasufumi Ota, Yoshihide Ueda, Masayo Hosoi, Rumiko Miyajima, Kazushige Hasegawa, Fukutaro Mizuhashi
Biosafety Research Center, Foods, Drugs and Pesticides (BSRC)
Journal of Toxicologic Pathology 23 (4) 253-260, 2010.

Spontaneous Fibrosarcoma with Pleomorphic Appearance in an Aged Brown Norway Rat

Tomoaki Tochitani, Kaoru Toyosawa, Izumi Matsumoto, Mami Kouchi, Yoshiko Michimae, Takatoshi Koujitani, Hitoshi Funabashi, Takaki Seki
Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd.
Journal of Toxicologic Pathology 23 (4) 261-263, 2010.

A Case of Canine Cutaneous Clear Cell Adnexal Carcinoma with Prominent Expression of Smooth Muscle Actin

Akiko Sakuma1, Shoko Nishiyama1, Kyohei Yasuno1, Tamio Ohmuro2, Junichi Kamiie3, Kinji Shirota1,3
1Research Institute of Biosciences, School of Veterinary Medicine, Azabu University, 2Ohmuro Veterinary Clinic, 3Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University
Journal of Toxicologic Pathology 23 (4) 265-269, 2010.

Relationship of Cell Proliferating Marker Expressions with PGE2 Receptors in Regenerating Rat Renal Tubules after Cisplatin Injection

Emi Yamamoto, Takeshi Izawa, Vetnizah Juniantito, Mitsuru Kuwamura, Jyoji Yamate
Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University
Journal of Toxicologic Pathology 23 (4) 271-275, 2010.

Journal of Toxicologic Pathology 23巻 4号

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