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Journal of Toxicologic Pathology 25巻 suppl号

発行元
日本毒性病理学会
ISSN
0914-9198
ISSN（オンライン）
1881-915X
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開始頁
SL-1 Toxicologic Pathology: Contribution to Drug Administration and Its Future
Yasuo OHNO
National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 1-1, 2012.
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SL-2 Principles for The Risk Assessment of Chemicals in Food As Applied by FAO/WHO Expert Meetings
Angelika TRITSCHER
Department of Food Safety and Zoonoses, World Health Organization
Journal of Toxicologic Pathology 25 (suppl) 2-2, 2012.
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S-1 Current Trends of Therapeutic Antibodies
Masami SUZUKI
Fuji Gotemba Research Labs., Chugai Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 3-3, 2012.
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S-2 MoA (Mode of Action) Analyses-A Toxicological Rationality in Pesticide Risk Assessment
Shogo OZAWA
Faculty of Pharmaceutical Sciences, Iwate Medical University
Journal of Toxicologic Pathology 25 (suppl) 3-3, 2012.
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S-3 The Juvenile Toxicity Study Guideline and Expectations for Toxicologic Pathology
Kazuhiro SHIMOMURA
Medicinal Safety Research Laboratories, DAIICHI SANKYO CO., LTD.
Journal of Toxicologic Pathology 25 (suppl) 4-4, 2012.
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S-4 The Role of Pathology in Alternative Methods for Toxicity Testing
Hajime KOJIMA
Division of Pharmacology, National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 4-4, 2012.
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WS-01 Evaluation of The Usefulness of MicroRNAs in Rat Hepatocarcinogenesis
Masahiko KUSHIDA
Sumitomo Chemical Co.Ltd.
Journal of Toxicologic Pathology 25 (suppl) 5-5, 2012.
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WS-02 The role of gap junctional intercellular communication in rat hepatocarcinogenesis and apoptosis
Aya NAIKI-ITO
Dept.of Exp.Pathol.and Tumor Biol., Nagoya City Univ.Grad.Sch.of Med.Sci.
Journal of Toxicologic Pathology 25 (suppl) 5-5, 2012.
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WS-03 Role of the Canonical Wnt Signaling Pathway in Proliferation of the Gastric Epithelial Cells
Akihiro HIRATA
Gifu University, Life Science Research Center, Division of Animal Experiment
Journal of Toxicologic Pathology 25 (suppl) 6-6, 2012.
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WS-04 Inhibition of NADPH oxidase, an endogenous superoxide inducer, suppressed progression of prostate cancer.
Shugo SUZUKI
Dept.of Exp.Pathol.and Tumor Biol., Nagoya City Univ.Grad.Sch.of Med.Sci., Pathol.Div., Nagoya City East Med.Ctr.
Journal of Toxicologic Pathology 25 (suppl) 6-6, 2012.
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WS-05 Establishment of a new invasive urinary bladder cancer model Identification of invasion-associated protein using human c-Ha-ras proto-oncogene transgenic rats
Min WEI
Department of Pathology, Osaka City University Graduate School of Medicine
Journal of Toxicologic Pathology 25 (suppl) 7-7, 2012.
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WS-06 Expression of Diagnostic Biomarkers in Central and Peripheral Squamous Cell Carcinoma of the Lung. Are They Different?
Jun FUKUOKA
Toyama University Hospital
Journal of Toxicologic Pathology 25 (suppl) 7-7, 2012.
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WS-07 Development of an analytical method for in vivo DNA adducts and its application to reporter gene transgenic rodents
Yuji Ishii
Div.Pathol., NIHS
Journal of Toxicologic Pathology 25 (suppl) 8-8, 2012.
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WS-08 Involvement of Epigenetic Alteration in the Enhancing Effects of Chromated Copper Arsenate on Ultraviolet B-induced Skin Carcinogenesis
Naofumi TAKAHASHI
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 25 (suppl) 8-8, 2012.
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WS-09 Possible Modes of Action Underlying Ochratoxin A-induced Renal Carcinogenesis
Daisuke HIBI
Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 9-9, 2012.
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WS-10 Functional Analysis of GPC3 as A Target Molecule for Noble Antibody Therapeutic
Atsuhiko Kato
Safety assessment department, Chugai Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 9-9, 2012.
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WS-11 Expression profiling of iron-regulatory factors in thioacetamide-induced rat acute hepatic injury
Takeshi IZAWA, Hiroshi MURAKAMI, Kavindra WIJESUDERA, Mitsuru KUWAMURA, Jyoji YAMATE
Osaka Prefecture University, Laboratory of Veterinary Pathology
Journal of Toxicologic Pathology 25 (suppl) 10-10, 2012.
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WS-12 Effects on the liver induced by the phase II drug-metabolizing enzyme inducers
Toshihiko MAKINO
Medicinal Safety Research Lab., Daiichi Sankyo Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 10-10, 2012.
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WS-13 Hematopoietic toxicity of T-2 toxin in mice
J SHINOZUKA
Safety Research Laboratory, Mitsubishi Tanabe Pharma
Journal of Toxicologic Pathology 25 (suppl) 11-11, 2012.
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WS-14 Studies on Eosinophilic Substance in the Mouse Nasal Septum
Takuya DOI
Pathology Department, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 25 (suppl) 11-11, 2012.
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WS-15 Pathological Studies on Glomerulonephropathy Induced by Bolus Injection with Dibasic Sodium Phosphate Solution in Rats
Noriko TSUCHIYA
Shionogi & Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 12-12, 2012.
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WS-16 Morphological Characteristics of Luteal Toxicity in Rats Treated with Ethylene Glycol Monomethyl Ether, Atrazine, or Bromocriptine
Yoshikazu TAKETA1),2), Kaoru INOUE1), Miwa TAKAHASHI1), Seigo HAYASHI1), Akiyoshi NISHIKAWA1), Jyoji YAMATE2), Midori YOSHIDA1)
1)Division of Pathology, National Institute of Health Sciences, 2)Laboratory of Veterinary Pathology, Osaka Prefecture University
Journal of Toxicologic Pathology 25 (suppl) 12-12, 2012.
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WS-17 Transitional Gene Expression Profiling of Ovarian Follicle in Rats Treated with Indomethacin and RU486
Kenjiro Tsubota
Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc.
Journal of Toxicologic Pathology 25 (suppl) 13-13, 2012.
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P-001 Calponin Expression in Cisplatin-Induced Rat Renal Tubulointerstitial Fibrosis, in Correlation with Myofibroblasts
Takahiro YUASA, Takeshi IZAWA, Mitsuru KUWAMURA, Jyoji YAMATE
Osaka Prefecture University
Journal of Toxicologic Pathology 25 (suppl) 13-13, 2012.
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P-002 Expression patterns of Biomarkers of renal injury in Cisplatin induced Rat Acute Renal Failure Model
Emi YAMAMOTO1), Koichi MASUNO1), Kae FUJISAWA1), Noriko TSUCHIYA1), Shuuichi MATSUSHIMA1), Nobuo TAKASU1), Mikinori TORII1), Takeshi IZAWA2), Mitsuru KUWAMURA2), Jyoji YAMATE2)
1)Shionogi & Co., Ltd., 2)Laboratory of Veterinary Pathology Osaka Prefecture University
Journal of Toxicologic Pathology 25 (suppl) 14-14, 2012.
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P-003 Pathobiological Study of Nephrotoxicity due to Polymyxin B
Atsuko YUASA, Yuuko MARUYAMA, Naohisa UMEYA, Takanori HIOKI, Hiroshi SATOH, Chihaya KAKINUMA
Safety Evaluation Center, Fujifilm Corporation
Journal of Toxicologic Pathology 25 (suppl) 14-14, 2012.
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P-004 Characterization of the Cultured Podocytes derived from Osborne-Mendel Rats and the Response of their Actin Cytoskeleton to Angiotensin II
Kyohei YASUNO1), Saori ARAKI1), Haruka SAKASHITA1), Ryosuke KOBAYASHI1), Kikumi OGIHARA2), Junichi KAMIIE3), Kinji SHIROTA1),3)
1)Research Institute of Biosciences, Azabu Univ., 2)Lab.Environ.Pathol., Azabu Univ., 3)Lab.Vet.Pathol., Azabu Univ.
Journal of Toxicologic Pathology 25 (suppl) 15-15, 2012.
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P-005 Morphometrical Study for Podocytes on Gender Difference in SD Rats Kidney Glomeruli
Masaya MOTOHASHI1), Isao TANAKA1), Toshie NISHIMOTO1), Masaru SHIRAI1), Hiroyuki TAKAHASHI2), Tomoko MUTO3), Akihiko SAKATA2), Hiroshi HANO2), Shin WAKUI1)
1)Department of Toxicology, Azabu University School of Veterinary Medicine, 2)Department of Pathology, The Jikei University School of Medicine, 3)Drug Safety Testing Center
Journal of Toxicologic Pathology 25 (suppl) 15-15, 2012.
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P-006 Intranuclear and Cytoplasmic Inclusions in Proximal Tubular Epithelium of the Kidney in Aged Wistar Hannover Rats
Natsumi SHIMOYAMA, Osamu KUSUOKA, Yuko YAMAGUCHI, Tomomi NAKAZAWA, Rie ANDOH, Toru HOSHIYA, Kazutoshi TAMURA
BOZO Research Center Inc.
Journal of Toxicologic Pathology 25 (suppl) 16-16, 2012.
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P-007 Urinary Cystatin C as a Biomarker for Diabetic Nephropathy and its Immunohistochemical Localization in Kidney in Zucker Diabetic Fatty (ZDF) rats
Yuko TOGASHI, Yoshiji ASAOKA, Yohei MIYAMOTO
Toxicology and Pharmacokinetics Lab., Pharmaceutical Research Lab., Toray Industries, Inc.
Journal of Toxicologic Pathology 25 (suppl) 16-16, 2012.
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P-008 Identification of novel biomarkers of rat renal carcinogenesis
Kyoko OKABE, Shotaro YAMANO, Min WEI, Masaki TAJIRI, Xiaori XIE, Masayuki KANKI, Mitsuaki KITANO, Hideki WANIBUCHI
Department of Pathology, Osaka City University Graduate School of Medicine
Journal of Toxicologic Pathology 25 (suppl) 17-17, 2012.
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P-009 Inhibitory mechanisms of HDAC inhibitor on prostate cancer cell proliferation
Shinya SATO1), Shugo SUZUKI1),2), Aya NAIKI1), Satoru TAKAHASHI1), Tomoyuki SHIRAI1)
1)Dept.of Exp.Pathol.And Tumor Biol., Nagoya City Univ., 2)Pathol.Div., Nagoya City East Med Ctr.
Journal of Toxicologic Pathology 25 (suppl) 17-17, 2012.
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P-010 Chemopreventive Effects of Purple Corn Color on Prostate Cancer
Ne LONG, Satoru TAKAHASHI, Tomoyuki SHIRAI
Dept.of Exp.Pathol. & Tumor Biol., Nagoya City Univ., Graduate school of medical sciences
Journal of Toxicologic Pathology 25 (suppl) 18-18, 2012.
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P-011 Assessment of Biomarkers in Gentamicin-induced Renal Lesions of Cynomolgus Monkeys
Kiyonori KAI, Takashi YAMAGUCHI, Shingo ARAKAWA, Yoko SUZUKI, Yu YOSHIMATSU, Munehiro TERANISHI, Atsushi SANBUISSHO
Daiichi Sankyo Co., Ltd.Medical Safety Research Laboratories
Journal of Toxicologic Pathology 25 (suppl) 18-18, 2012.
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P-012 Immunohistochemical Examination of Progressive Glomerulonephropathy in Common Marmosets (Callithrix jacchus)
Naoaki YAMADA1), Nanako SATO2), Junichi KAMIIE3), Junko SATO1), Hiroko KOKOSHIMA1), Toshio ITOH2), Kinji SHIROTA3), Minoru TSUCHITANI1)
1)Mitsubishi Chemical Medience Corporation, 2)Central Institute for Experimental Animals, 3)Azabu University
Journal of Toxicologic Pathology 25 (suppl) 19-19, 2012.
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P-013 A study of partial nephrectomized model using common marmoset (Callithrix jacchus) monkeys
Kensuke MYOJO, Itaru YAMAGUCHI, Noriko ONODA, Yui SUZUKI, Hiroko SANADA, Chie TAKADA, Minami IMAIZUMI, Naoya KIMOTO, Katsumi TAKABA
Toxicological Research Laboratories, Kyowa Hakko Kirin Co.Ltd.
Journal of Toxicologic Pathology 25 (suppl) 19-19, 2012.
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P-014 Effects of Pentachlorophenol and N-acetylcysteine on Safrole-induced Hepatocarcinogenesis in F344 gpt delta rats
Meilan JIN1), Aki KIJIMAa1), Yuta SUZUKI1), Daisuke Hibi1), Tomoki INOUE1), Yuji ISHII1), Takehiko NOHMI2), Kumiko OGAWA1), Akiyoshi NISHIKAWA3), Takashi UMEMURA1)
1)Division of Pathology, National Institute of Health Sciences, 2)Division of Genetics & Mutagenesis, National Institute of Health Sciences, 3)Biological Safety Research Center, National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 20-20, 2012.
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P-015 Enhancing Effects of Flumequine on in vivo Mutagenicity of MeIQx in the Mouse Liver
Ken KURODA1), Aki KIJIMA1), Kohei MATSUSHITA1), Meilan JIN1), Shinji TAKASU1), Yuji ISHII1), Yukio KODAMA2), Kumiko OGAWA1), Takashi UMEMURA1)
1)Division of Pathology, National Institute of Health Sciences, 2)Division of Toxicology, National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 20-20, 2012.
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P-016 Examination of in vivo mutagenicity and carcinogenicity in the rat with Kojic acid
Masaki TAJIRI, Min WEI, Kyoko OKABE, Shotaro YAMANO, Satoki FUKUNAGA, Syuji HAYASHI, Hideki WANIBUCHI
Dept.Pathol., Osaka City Univ., Grad.Sch.Med.
Journal of Toxicologic Pathology 25 (suppl) 21-21, 2012.
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P-017 Possible Involvement of Genotoxic Mechanisms in 5-(hydroxymethyl)-2-furfural-Induced Hepatocarcinogenesis in Mice.
Kohei MATSUSHITA1), Yuji ISHII1), Aki KIJIMA1), Meilan JIN1), Shinji TAKASU1), Ken KURODA1), Yukio KODAMA2), Kumiko OGAWA1), Takashi UMEMURA1)
1)Division of Pathology, National Institute Health Science, 2)Division of Toxicology, National Institute Health Science
Journal of Toxicologic Pathology 25 (suppl) 21-21, 2012.
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P-018 IQ Promotes Mouse Hepatocarcinogenesis by Activating Transforming Growth Factor-β and Wnt/β-catenin Signaling Pathways
Xiao-Li Xie, Min Wei, Anna Kakehashi, Masaki Tajiri, Kyoko Okabe, Yoshiyuki Tago, Hideki Wanibuchi
1st Dept.Pathol., Osaka City Univ., Grad., Sch.Med.
Journal of Toxicologic Pathology 25 (suppl) 22-22, 2012.
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P-019 Analysis of gene expression in rat liver treated non-genotoxic carcinogens for 28 days
Masayuki Kanki1),2), Min Wein2), Anna Kakehashi2), Shotaro Yamano2), Hideki Wanibuvhi3)
1)Astellas Pharma Inc, 2)Osaka City University Medical School
Journal of Toxicologic Pathology 25 (suppl) 22-22, 2012.
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P-020 Threshold Levels for Tumor Promoting Effects of Ethyl tertiary-Butyl Ether (ETBE) on Hepatic and Renal Carcinogenesis in Rats
Norio IMAI1), Akihiro HAGIWARA1), Yuko DOI1), Seiko TAMANO1), Kasuke NAGANO2), Shoji FUKUSHIMA2)
1)DIMS Inst.Med.Sci., 2)Japan Bioassay Research Center, JISHA
Journal of Toxicologic Pathology 25 (suppl) 23-23, 2012.
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P-021 Modification of Liver Tumor Promotion Effects with Co-administration of β-Naphthoflavone and Piperonyl Butoxide in Rats
Hitomi Hayashi1),2), Reiko Morita1),2), Eriko Taniai1),2), Atsunori Yafune1),2), Masahiro Hayashi3), Masaru Kindaichi3), Kazuhiko Suzuki1), Makoto Shibutani1), Kunitoshi Mitsumori1)
1)Lab.Vet.Pathol., Tokyo Univ.Agri. & Tech., 2)Pathogen.Vet.Sci., United Grad.Sch.Vet.Sci., Gifu Univ., 3)Gotemba Research Institute, Bozo Research Center Inc
Journal of Toxicologic Pathology 25 (suppl) 23-23, 2012.
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P-022 Toxicopathological Impact of Co-exposure to Different Phthalate Esters on the Liver and Male Genital System by 90 Days Repeated Administration in Rats
Kazuhiko SUZUKI1), Eriko TANIAI1),2), Atsushi ONO3), Atsunori YAFUNE1),2), Takumi OHISHI1), Sayaka KEMMOCHI1),2), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2)Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University, 3)Division of Risk Assessment, National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 24-24, 2012.
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P-023 The Role of Constitutive Androstane Receptor in Liver Hypertrophy by Triazole Fungicides.
Kei TAMURA1), Kaoru INOUE1), Miwa TAKAHASHI1), Saori Matsuo1), Kaoru IRIE1), Syogo OZAWA2), Kumiko OGAWA1), Akiyoshi NISHIKAWA3), Midori YOSHIDA1)
1)Div.Pathol., NIHS, 2)Dept.Pharmacodynamics Mol.Genetics, Sch.Pharmacy, Iwate Med.Univ., 3)Biol.Safety Res.Ctr.Natl.Inst.Health Sci.
Journal of Toxicologic Pathology 25 (suppl) 24-24, 2012.
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P-024 Expression of cell proliferation-related proteins and involvement of constitutive androstane receptor (CAR) in altered liver foci/adenomas induced by CYP2B inducers
Kaoru INOUE1), Yohei SAKAMOTO1), Kei Tamura1), Miwa TAKAHASHI1), Saori MATSUO1), Kumiko OGAWA1), Akiyoshi NISHIKAWA2), Syogo OZAWA3), Midori YOSHIDA1)
1)Div.Pathol., Natl.Inst.Health Sci., 2)Biol.Safety Res.Ctr, Natl.Inst.Health Sci., 3)Dept.Pharmacodynamics Mol.Genetics., Sch.Pharmacy, Iwate Med.Univ.
Journal of Toxicologic Pathology 25 (suppl) 25-25, 2012.
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P-025 Transcriptional Down-regulation of ALT Gene and AST Gene in the Liver Induced by Phenobarbital Sodium
Ryoichi OHTSUKA1), Hodaka SUZUKI2), Makio TAKEDA1), Satoru YAMAGUCHI1), Sayuri KOJIMA1), Mariko TOMITA1), Aya OHNUMA1), Naofumi TAKAHASHI1), Maki KUWAHARA1), Toshinori YOSHIDA1), Nobuaki NAKASHIMA1), Takanori HARADA1)
1)Toxicology Division, Institute of Environmental Toxicology, 2)Division of Biomedical Food Research, National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 25-25, 2012.
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P-026 Interstrain comparison of pathophysiological condition in high-fat (70kcal%) diet fed rats
Takahisa NOTO, Ayano TAKAUCHI, Yoshika YAMAKAWA, Yuichi MURAKAMI, Katsuhisa SHIRAKI, Yuji OISHI, Masahiro MATSUMOTO
Toxicologic Pathology, Drug Safety Research Laboratories, Astellas Pharma Inc.
Journal of Toxicologic Pathology 25 (suppl) 26-26, 2012.
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P-027 M1/M2 Macrophage Polarization in Thioacetamide (TAA)-induced Acute Rat Liver Lesions
Kavindra WIJESUNDERA, Hossain Md.GOLBAR, Chisa ICHIKAWA, Miyuu TANAKA, Takeshi IZAWA, Mitsuru KUWAMURA, Jyoji YAMATE
Osaka Prefecture University, Laboratory of Veterinary Pathology
Journal of Toxicologic Pathology 25 (suppl) 26-26, 2012.
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P-028 Localization of Connexin32 and Connexin26 in Spontaneous Liver Lesions in Mice
Munehiro TERANISHI, Isao IGARASHI, Yoko SUZUKI, Toshihiko MAKINO, Kiyonori KAI, Atsushi SANBUISSHO
Medicinal Safety Research Lab., Daiichi Sankyo Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 27-27, 2012.
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P-029 Antibodies useful for Macrophage Detection and Distribution in the Liver in Cynomolgus Monkeys
Junko FUJISHIMA1), Chika HIROWATARI1), Takeshi IZAWA2), Tomohiro FURUKAWA1), Kimiaki HIRAKAWA1), Akiko MORIYAMA1), Tsuyoshi YOSHIKAWA1), Yasuhiro KAMIMURA1), Jyoji YAMATE2)
1)Shin Nippon Biomedical Laboratories, Ltd., 2)Laboratory of Veterinary Pathology, Osaka Prefecture University
Journal of Toxicologic Pathology 25 (suppl) 27-27, 2012.
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P-030 Identification of Novel Protein Biomarkers for Human Liver Cancer
Anna KAKEHASHI, Shotaro YAMANO, Min WEI, Xiaoli XIE, Masanori TAKESHITA, Masahiko KUSHIDA, Hideki WANIBUCHI
Osaka City Univ., Grad.Sch.Med.
Journal of Toxicologic Pathology 25 (suppl) 28-28, 2012.
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P-031 Effects of carbon nanotubes on lung tissues, cell proliferation, and gene expression
Masumi SUZUI1), Jiegou XU2), Katsumi FUKAMACHI1), Mitsuru FUTAKUCHI1), Jun KANNO3), Akihiko HIROSE4), Hiroyuki TSUDA2)
1)Dept.of Mol.Toxicol.Grad.Sch.of Medical Sciences, Nagoya City Univ., 2)Lab.of Nano Toxicol.Project, Nagoya City Univ., 3)Div.of Cell & Mol.Tox., Natl.Inst.Health Sci., 4)Div.Risk Assessment, Natl.Inst.Health Sci.
Journal of Toxicologic Pathology 25 (suppl) 28-28, 2012.
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P-032 Application of Spiral Array to Survival Analysis of Lung Cancer - Tissue Heterogeneity of Ki67 Matters
Tomonori TANAKA1), Jun FUKUOKA1), Takashi HORI1),2)
1)Toyama University Hospital, 2)Pathology Institute Corp.
Journal of Toxicologic Pathology 25 (suppl) 29-29, 2012.
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P-033 Ovarian toxicity potential of dibromoacetic acid in rats
Seigo HAYASHI1),3), Kaoru INOUE1), Miwa TAKAHASHI1), Yoshikazu TAKETA1), Saori MATSUO1), Gen WATANABE2), Yoshikazu TAYA2), Hiroetsu SUZUKI3), Akiyoshi NISHIKAWA1), Midori YOSHIDA1)
1)Division of Pathology, National Institute of Health Sciences, 2)Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, 3)Laboratory of Veterinary Physiology, Nippon Veterinary Life Science University
Journal of Toxicologic Pathology 25 (suppl) 29-29, 2012.
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P-034 Histological Characteristics of Ovaries in Wistar Hannover Rats: The Comparisons with SD Rats
Satomi HASHIMOTO, Junko SATO, Takuya DOI, Yumi WAKO, Yuki TOMONARI, Naoaki YAMADA, Minoru TSUCHITANI
Pathology Department, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 25 (suppl) 30-30, 2012.
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P-035 Histopathological Characteristics of Testicular Toxicities Induced by Topoisomerase Inhibitor I (TP300) in Rats: Morphological Changes of Nucleus in Spermatid
Kenji ADACHI, Akio MIYOSHI, Kaori ISOBE, Etsuko Fujii, Atsuhiko KATO, Masami SUZUKI
Safety Assessment Department, Chugai Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 30-30, 2012.
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P-036 Comparison of Age-related Male Reproductive Performance, Spermatozoa and Spermatogenesis in RccHan: WIST Rats
Ikuro TAKAKURA, Ryohei YOKOI, Yukari TERASHIMA, Tomoya ONOZATO, Yoshimasa MARUYAMA, Tomonobu CHINO, Toru TAHARA, Toru TAMURA, Kazuo KOBAYASHI, Junji KURODA
Toxicology Research Laboratory, R & D, Kissei Pharmaceuticals Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 31-31, 2012.
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P-037 Suppression of Lymph Node Metastasis by New Endogenous Soluble VEGF Receptor-2 Isoform in a Mouse Mammary Cancer Model
M.A.Shibata1), J.Ambati2), R.J.C.Albuquerque2), J.Morimoto3)
1)Osaka Health Sci.Univ., 2)Univ.Kentucky, 3)Osaka Med.Coll.
Journal of Toxicologic Pathology 25 (suppl) 31-31, 2012.
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P-038 Age related susceptibility of MNU-induced mammary carcinogenesis in female Lewis rats
Tomo SASAKI1),2), Katsuhiko YOSHIZAWA1), Ayako KIMURA1), Yen-Chang LAI1), Yuichi KINOSHITA1), Hisanori MIKI1), Takashi YURI1), Norihisa UEHARA1), Airo TSUBURA1)
1)Department of pathology II, Kansai Medical University, 2)Research Laboratories, Maruho Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 32-32, 2012.
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P-039 Expression of TWIST-1 in Stromal Cells of Rat Mammary Fibroadenoma.
Satomi FUNAHASHI, Yasumasa OKAZAKI, Qian Hu, Shan Hwu CHEW, Hirotaka NAGAI, Shinya TOYOKUNI
Nagoya University Graduate School of Medicine, Department of Pathology and Biological Responses
Journal of Toxicologic Pathology 25 (suppl) 32-32, 2012.
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P-040 Analysis of Cryoglobulin Reactivity Against Worm Antigens in Experimentally Cryoglobulinemia Model of ICR Mice Induced with Capillaria Hepatica Infection
Naoyuki Aihara1), Moe Yamada1), Akane Kashimura1), Junichi Kamiie1), Kinji Shirota1),2)
1)Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 2)Research Institute of Biosciences, School of Veterinary Medicine, Azabu University
Journal of Toxicologic Pathology 25 (suppl) 33-33, 2012.
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P-041 Influence of variable host immunity on the incidence of cryoglobulinemia in mice experimentally infected with Capillaria hepatica.
Moe Yamada1), Naoyuki Aihara1), Akane Kashimura1), Erika Takahashi1), Shin Wakabayashi1), Junichi Kamiie1), Kinji Shirota1),2)
1)Laboratory of Veterinary Pathology, School of Veterinary Medicine, Azabu University, 2)Research Institute of Biosciences, School of Veterinary Medicine, Azabu University
Journal of Toxicologic Pathology 25 (suppl) 33-33, 2012.
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P-042 Immunopathological Changes in Immunotoxicological Study of Mice Treated with Methoxychlor.
Aya OHNUMA, Naofumi TAKAHASHI, Tomoki FUKUYAMA, Koichi HAYASHI, Hideo UEDA, Yuko SHIMADA, Katsumi SOMA, Maki KUWAHARA, Mutsumi KUMAGAI, Toshinori YOSHIDA, Yuko CHIBA, Nobuaki NAKASHIMA, Hiroaki AOYAMA, Takanori HARADA, Tadashi KOSAKA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 25 (suppl) 34-34, 2012.
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P-043 Pathological Examination of Upper Respiratory Tract in Rats Administered Amiodarone Hydrochloride for 4-days
Seiya OGATA1), Tomohiro WATANABE1), Sanae TAKADA1), Naoyuki MAEDA1), Yoshiro TANI1), Atsushi SANBUISSHO2)
1)Medicinal Safety Research Laboratories, Daiichi-Sankyo Co., Ltd., Tokyo, 2)Medicinal Safety Research Laboratories, Daiichi-Sankyo Co., Ltd., Shizuoka
Journal of Toxicologic Pathology 25 (suppl) 34-34, 2012.
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P-044 Ultrastructure of the Bronchial Cilia in Congenital Hydrocephalic Rats
Fumi SHIMIZU, Nobuyuki SEKI, Hitomi HAMAJOU, Ryoutarou HORI, Yoshimasa ISHIMURA, Hitoshi KANDORI, Hisashi ANAYAMA, Yoko HARA, Kiyoshi MATSUMOTO, Ryo FUKUDA
Drug Safety Research Laboratories, Takeda Pharmaceutical Company Limited
Journal of Toxicologic Pathology 25 (suppl) 35-35, 2012.
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P-045 Histopathological study of the mechanism of cardiac toxicity by microtubule-disassembling drugs
Ryota YAMAMOTO, Minoru ANDO, Katsuya SUZUKI, Tomo SUZUKI, Yuriko NAGATA, Chie HATA, Kayoko KOMATSU, Kazumi UCHIDA, Toshihide KOBAYASHI, Shoichi KADO, Kimiyuki KANEKO
Yakult Central Institute for Microbiological Research
Journal of Toxicologic Pathology 25 (suppl) 35-35, 2012.
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P-046 Signet ring cell type adenocarcinoma of unknown origin in a rat
Rumiko MIYAJIMA, Atsushi SHIGA, Kazushige HASEGAWA, Masayo HOSOI, Yoshihide UEDA, Yasufumi OTA, Shigeaki TAKAMI, Isao NARAMA
BSRC
Journal of Toxicologic Pathology 25 (suppl) 36-36, 2012.
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P-047 A Poorly Differentiated Salivary gland Adenocarcinoma with Prominent Squamous Metaplasia in a Pregnant Wistar Hannover Rat
Yuko SHIMADA, Naofumi TAKAHASHI, Satoshi AKEMA, Aya OHNUMA, Katsumi SOMA, Akira SATO, Maki KUWAHARA, Nobuaki NAKASHIMA, Takanori HARADA, Toshinori YOSHIDA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 25 (suppl) 36-36, 2012.
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P-048 A Paraganglioma at Posterior Wall of Left Atrium Originated from Aortic Body in a Wistar Hannover Rat
Yinghua LI1), Kazumi SHIRAIWA2), Kyeongnam KO1), Jemin MOON1), Sunhee PARK1), Miju LEE1), Sunhee SHIN1), Myoungjun KIM1), Hosong JANG1), Yonghoon LEE1), Duyeol KIM1), Jin Seok KANG3), Jongkoo KANG4)
1)Biotoxtech Co., Ltd., 2)CMIC BIORESEARCH CENTER Co., Ltd., 3)Department of Biomedical Laboratory Science, Namseoul University, 4)College of Veterinary Medicine, Chungbuk National University
Journal of Toxicologic Pathology 25 (suppl) 37-37, 2012.
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P-049 A case of intratubular seminoma in a young SD rat
Noriaki ISHIGAMI, Kouji SHIMOUCHI, Daisuke HIBI, Yuh YOKOO, Yasushi HIROTA, Yutaka SHICHINO
Safety Research Laboratories, Ono Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 37-37, 2012.
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P-050 Eosinophilic Granules Observed in the Mammary Gland of a Cynomolgus Monkey
Hirofumi YAMAUCHI, Naomi INUI, Hideki YAMASAKI, Takeshi WATANABE, Yuichi TAKAI, Hironobu YASUNO, Ryo FUKUDA
Drug Safety Research Laboratories, Takeda Pharmaceutical Company Limited
Journal of Toxicologic Pathology 25 (suppl) 38-38, 2012.
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P-051 Spontaneous Squamous Metaplasia in the Prostate of Rabbits
Azusa KOBAYASHI, Koshirou KATOKU, Shino KUMABE, Mikio MITSUISHI, Takafumi OSHIKATA, Takeshi KANNO, Masao HAMAMURA
Pathology Department, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 25 (suppl) 38-38, 2012.
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P-052 Interstitial Lung Disease in Beagle Dogs
Katsumi SOMA, Yuko SHIMADA, Naofumi TAKAHASHI, Satoshi AKEMA, Aya OHNUMA, Maki KUWAHARA, Nobuaki NAKASHIMA, Takanori HARADA, Toshinori YOSHIDA
The Institute of Environmental Toxicology
Journal of Toxicologic Pathology 25 (suppl) 39-39, 2012.
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P-053 Histopathological studies on the siderotic nodule of the spleen in beagle dogs.l
Jun Watanabe, Seiji Miyoshi, Hirofumi Hatakeyama, Haruko Koizumi, Mitsutoshi Watanabe, Akihito Shimoi
Ina Research, Inc.Research Center
Journal of Toxicologic Pathology 25 (suppl) 39-39, 2012.
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P-054 Inflammatory Fibroid Polyp in the Duodenum of Common Marmoset (Callithrix Jacchus)
Yusuke Yokouchi, Masako Imaoka, Ayako Sayama, Atsushi Sanbuissho
Medicinal Safety Reseach Laboratories, Daiichi-Sankyo Co., Ltd
Journal of Toxicologic Pathology 25 (suppl) 40-40, 2012.
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P-055 nNOS or iNOS expression level is not involved in the different susceptibility to dopaminergic neurotoxicity induced by MPTP between C57BL/6 and BALB/c mice
Tsuyoshi ITO, Kazuyuki UCHIDA, Hiroyuki NAKAYAMA
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Journal of Toxicologic Pathology 25 (suppl) 40-40, 2012.
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P-056 Changes of Nigrostriatal Tyrosine Hydroxylase (TH) and Dopamine Transporter (DAT) in the Hamster After a Single Intrastriatal Injection of 6-Hydroxidopamine
Sebastian Rodriguez, Kazuyuki Uchida, Hiroyuki Nakayama
Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Journal of Toxicologic Pathology 25 (suppl) 41-41, 2012.
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P-057 Light and scanning electron microscopic changes of rat brain treated with multiwalled carbon nanotubes by intratracheal instillation
Kenji TAKANOBU, Yumi UMEDA, Hideki SENOH, Shigetoshi AISO, Shoji FUKUSHIMA
Japan Bioassay Research Center, Japan Industrial Safety and Health Association (JISHA)
Journal of Toxicologic Pathology 25 (suppl) 41-41, 2012.
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P-058 Brain lesions by Ketamine Treatment in the Juvenile Rats
Kazuhiro HAYAKAWA1), Mi-Ju LEE2), Myoung-Jun KIM2), Sun-Hee PARK2), Yinghua LI2), Jong-Koo KANG2), Jiro SONODA3), Satoru HOSOKAWA3), Satoru MOTOOKA1), Toyohiko AOKI3), Kazuo TSUKIDATE3)
1)Sunplanet Co., Ltd., 2)Biotoxtech Co., Ltd., 3)Eisai Co.Ltd.
Journal of Toxicologic Pathology 25 (suppl) 42-42, 2012.
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P-059 Effect of developmental exposure to nicotine on the neurogenesis of the hippocampal dentate gyrus in rats
Takumi OHISHI1),2), Liyun WANG1), Hirotoshi AKANE1), Ayako SHIRAKI1), Reiko MORITA1),3), Atsuhiro YAFUNE1),3), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab.Vet.Pathol., Tokyo Univ.Agri.Tech., 2)Gotemba Laboratory, Bozo Research Center Inc., 3)Pathog.Vet.Sci., United Grad.Sch.Vet.Sci., Gifu Univ.
Journal of Toxicologic Pathology 25 (suppl) 42-42, 2012.
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P-060 Effect of Developmental Exposure to Chlorpyrifos on the Neurogenesis in the Hippocampal Dentate Gyrus in Mice
Liyun WANG1), Takumi OHISHI1), Hirotoshi AKANE1),2), Hitomi HAYASHI1),2), Sayaka KEMMOCHI1),2), Eriko TANIAI1),2), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 2)Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University
Journal of Toxicologic Pathology 25 (suppl) 43-43, 2012.
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P-061 Early Changes in Medulloblastoma and Cerebellar Development in Patch1 Heterozygous Knockout Mice
Saori Matsuo, Miwa Takahashi, Kaoru Inoue, Kaoru Irie, Kei Tamura, Kumiko Ogawa, Midori Yoshida
Division of Pathology, National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 43-43, 2012.
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P-062 Development of An Early Induction Model of Medulloblastoma in Ptch1 Heterozygous Knockout Mice Initiated with N-ethyl-N-nitrosourea
Miwa TAKAHASHI, Saori MATSUO, Kaoru INOUE, Kei TAMURA, Kaoru IRIE, Kumiko OGAWA, Midori YOSHIDA
Div.Pathol., Natl.Inst.Health Sci.
Journal of Toxicologic Pathology 25 (suppl) 44-44, 2012.
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P-063 Histopathological study of lesion of the spinal cord in SJL/J mouse's EAE model
Minoru ANDO, Shoichi KADO, Tomo SUZUKI, Ryota YAMAMOTO, Yuriko NAGATA, Chie HATA, Yuji FUKUHARA, Toshihide KOBAYASHI, Kazumi UCIDA, Kimiyuki KANEKO
Yakult Central Institute for Microbiological Research
Journal of Toxicologic Pathology 25 (suppl) 44-44, 2012.
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P-064 Utility of Immunohistochemical Application for Glial Brain Tumors in Rats
Ryuichi NAKAMURA1), Tomonari NISHIMURA1), Taehito OCHIAI1), Satomi NAKADA2), Mariko NAGATANI3), Hiroyuki OGASAWARA1)
1)Asubio Pharma Co., Ltd., 2)Daiichi Sankyo Propharma Co., Ltd., 3)Bozo Research Center Inc.
Journal of Toxicologic Pathology 25 (suppl) 45-45, 2012.
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P-065 GFAP-Positive Neoplastic Cells in Spontaneous Oligodendroglioma and Mixed Glioma of Rats
Mariko NAGATANI1), Tsubasa SAITO1), Ryo ANDO1), Toko OHIRA1), Hiroshi EDAMOTO1), Kenichiro KASAHARA1), Kazutoshi TAMURA1), Kazuyuki UCHIDA2)
1)Pathology Department, BOZO research Center Inc., 2)Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Journal of Toxicologic Pathology 25 (suppl) 45-45, 2012.
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P-066 Background Data of Retinal Function and Morphology in Wistar Hannover (RccHanTM: WIST) Rats
Yulin YAO, Osamu KATSUTA
Santen Pharmaceutical Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 46-46, 2012.
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P-067 N-Ethyl-N-Nitrosourea Induces Retinal Photoreceptor Damage in Adult Rats
Katsuhiko YOSHIZAWA1), Tomo SASAKI1),4), Norihisa UEHARA1), Maki KURO2), Ayako KIMURA1), Yuichi KINOSHITA1),3), Hisanori MIKI1), Takashi YURI1), Airo TSUBURA1)
1)Pathology II, Takii Hospital, Kansai Medical University, 2)Ophthalmology, Takii Hospital, Kansai Medical University, 3)Cytopathology, Takii Hospital, Kansai Medical University, 4)Research Laboratories, Maruho Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 46-46, 2012.
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P-068 Pathogenesis of Mice Ocular Coloboma: Relation between Basement Membrane Disintegration and Macrophage Recruitment at Optic Fissure Margin
Naho TSUJI, Kiyokazu OZAKI, Isao NARAMA, Tetsuro MATSUURA
Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University
Journal of Toxicologic Pathology 25 (suppl) 47-47, 2012.
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P-069 Oto-Neurotoxicity Induced by 6-Aminonicotinamide, A Potent Antimetabolite of Nicotinamide, in Mice
Satoshi SASAKI, Satomi HASHIMOTO, Kazufumi KAWASAKO, Naoaki YAMADA, Yuki TOMONARI, Yumi WAKO, Minoru TSUCHITANI
Pathology Dep., Nonclinical Research Center, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 25 (suppl) 47-47, 2012.
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P-070 Feasibility Analysis of Whole Brain Fixation with Methacarn for Global Molecular Analysis in Specific Brain Areas of Rats
Hirotoshi AKANE1), Fumiyo SAITO2), Hidenori YAMANAKA2), Ayako SHIRAKI1), Takumi OHISHI1), Liyun WANG1), Hitomi HAYASHI1),3), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab.Vet.Pathol., Tokyo Univ.Agricul.Technol., 2)Chem.Eval.Res.Inst., Chem.Assess.Res.Centr., 3)Pathogen.Vet.Sci., United Grad.Sch.Vet.Sci., Gifu Univ.
Journal of Toxicologic Pathology 25 (suppl) 48-48, 2012.
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P-071 Novel Rapid Tissue Fixation by Using a Water Oven (Superheated Steam Oven)
Michiyo SHIMADA1), Norio AKAOGI1), Taneo FUKUDA2), Aya GOTO3), Yuki SEKI3), Yoshikazu TAKETA3), Etsuko OTA3), Kyoko NAKANO3), Jiro SONODA3), Akira INOMATA3), Satoru HOSOKAWA3)
1)Tsukuba Pathology Group, Sunplanet Co., Ltd., 2)Preclinical Safety Research Laboratories, Kawashima Division, Sunplanet Co., Ltd., 3)Drug Safety Tsukuba, Eisai Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 48-48, 2012.
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P-072 Muscle Injury Tests Using Erector Spinae in Minipigs
Tadashi ITOH, Takahiko NAGASE, Katsuhiro HIGUCHI, Kazuyoshi NAITO, Shin-ya YABUKI, Jun IMAI, Hitoshi KIMURA
Nihon Bioresearch Inc.
Journal of Toxicologic Pathology 25 (suppl) 49-49, 2012.
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P-073 Histological Changes Associated with Long-Term Feeding in Clawn Miniature Pigs
Atsushi ISOBE1), Tomoki INOUE1), Masako TASAKI1), Hisako TERAO1), Atsushi SAKAOKA1), Junko SOUBA1), Masayoshi KANISAWA2), Hitomi HAGIWARA1)
1)Terumo Corporation, 2)Yokohama City University School of Medicine
Journal of Toxicologic Pathology 25 (suppl) 49-49, 2012.
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P-074 Development of Two-Stage Ultra-Short-Term Carcinogenicity Model Using rasH2 Mice - Evaluation of Skin Tumor Promoting Effects in rasH2 and Non-Tg Mice
Mayuko SUGURO1), Mayumi KAWABE1), Takamasa NUMANO1), Fumio FURUKAWA1), Kouji URANO2), Hideki TSUTSUMI2)
1)DIMS Institute of Medical Science, Inc., 2)Central Institute for Experimental Animals
Journal of Toxicologic Pathology 25 (suppl) 50-50, 2012.
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P-075 Granulation Tissue in the Process of Regeneration of Rat Skin Injury -Case Report in a Wistar-Hanover Rat-
Mizuho Takagi, Masayuki Kemi, Kazuko Tsurumoto, Maki Noguchi, Minatsu Haruki, Yachiyo Fukunaga, Koh Ohashi, Hiroshi Kuno
Pathology Department, Tsukuba Institute, Bozo Research Center Inc.
Journal of Toxicologic Pathology 25 (suppl) 50-50, 2012.
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P-076 Histopathological Changes of the Dorsal Skin by Preparative Procedures in Dermal Administration to Beagle Dogs
Shino KUMABE, Mikio MITSUISHI, Azusa KOBAYASHI, Takafumi OSHIKATA, Koshirou KATOKU, Takeshi KANNO, Masao HAMAMURA
Pathology Department, Nonclinical Research Center, Mitsubishi Chemical Medience Corporation
Journal of Toxicologic Pathology 25 (suppl) 51-51, 2012.
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P-077 Antimicrobial agent, Tetracycline, enhanced upper alimentary tract Candida albicans infection and its-related mucosal proliferation in alloxan-induced diabetic rats
Tomoya Sano1), Kiyokazu Ozaki1), Yasushi Kodama2), Tetsuro Matsuura1), Isao Narama1)
1)Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 2)Laboratory of Molecular and Cellular Toxicology, Faculty of Pharmaceutical Sciences, Hiroshima International University
Journal of Toxicologic Pathology 25 (suppl) 51-51, 2012.
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P-078 Experimental Candida albicans infection induces chronic inflammation and mucosal proliferation of upper alimentary tract in alloxan-induced diabetic rats
Sakura HARUGUCHI1), Tomoya SANO1), Yasushi KODAMA2), Naho TSUJI1), Tetsuro MATSUURA1), Isao NARAMA1), Kiyokazu OZAKI1)
1)Department of Pathology, Faculty of Pharmaceutical Sciences, Setsunan University, 2)Laboratory of Molecular and Cellular pharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University
Journal of Toxicologic Pathology 25 (suppl) 52-52, 2012.
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P-079 Gene Expression Analysis of a Helicobacter pylori-Infected and High-Salt Diet-Treated Mouse Gastric Tumor Model
Takeshi TOYODA1),2), Tetsuya TSUKAMOTO3), Shinji TAKASU1), Liang SHI4), Ayumi SAITO5), Noriko SAITO2), Masae TATEMATSU6), Young-Man CHO1), Akiyoshi NISHIKAWA7), Kumiko OGAWA1)
1)Div.Pathol., Natl.Inst.Health Sci., 2)Div.Oncol.Pathol., Aichi Cancer Ctr.Res.Inst., 3)Dept.Pathol., Fujita Health Univ.Sch.Med., 4)Prod.Tech.Ctr., Mitsui Chem, Inc., 5)Dept.Pathol.Matrix Biol., Mie Univ.Grad.Sch.Med., 6)Japan Bioassay Res.Ctr., 7)Biol.Safety Res.Ctr., Natl.Inst.Health Sci.
Journal of Toxicologic Pathology 25 (suppl) 52-52, 2012.
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P-080 Mouse colon cancer model using benzo[α]pyrene and dextran sulfate sodium: histological analysis in the process of an early stage of neoplastic lesion
Jiro SONODA1), Yuki SEKI1), Atsushi HAKURA1), Ikuo MORI2), Satoru HOSOKAWA1), Aya GOTO1), Akira INOMATA1), Kyoko NAKANO1), Etsuko OHTA1), Yoshikazu TAKETA1), Kazuhiro HAYAKAWA3), Akiyoshi SUGANUMA1), Toyohiko AOKI4), Kazuo TSUKIDATE1)
1)Tsukuba Drug Safety, Global Drug Safety, Eisai Co., Ltd., 2)Experiment Unit, Tsukuba Department, Sunplanet Co., Ltd., 3)Preclinical Safety Research Laboratories, Kawashima Division, Sunplanet Co., Ltd., 4)Non-clinical, Global Regulatory, Eisai Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 53-53, 2012.
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P-081 Effect of Caloric Restriction and High Fat Diet on Azoxymethane-induced Carcinogenesis in LETO and OLETF Rats
Chie TAKASU, Keisuke IZUMI
Dept.of Mol.and Environ.Pathol., Inst.of Health Biosciences, The Univ.of Tokushima Grad.Sch.
Journal of Toxicologic Pathology 25 (suppl) 53-53, 2012.
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P-082 Modifying effect of castration in PhIP-induced colon carcinogenesis
Shigeyuki SUGIE1), Takeru OYAMA2), Takuji TANAKA3)
1)Dept.Pathol.Murakami Memorial Hosp.Asahi Univ., 2)Dept.Pathol.Kanazawa Med.Univ., 3)Tokai Cytopathol.Inst.Cancer Res.Prev.
Journal of Toxicologic Pathology 25 (suppl) 54-54, 2012.
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P-083 Effects of an Angiotensin II Receptor Blocker on Obesity Associated Colon Carcinogenesis
Shinji TAKASU1),2), Michihiro MUTOH2), Yoshie HIFUMI2), Keiji WAKABAYASHI3), Hitoshi NAKAGAMA2)
1)Div.Pathol., Natl.Inst.Health Sci., 2)Div.Cancer Development System, Natl.Cancer Ctr.Res.Inst., 3)Inst.for Environ.Sci., Univ.of Shizuoka
Journal of Toxicologic Pathology 25 (suppl) 54-54, 2012.
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P-084 Congenic db/db-ApcMin/+ Mice Increase Intestinal Tumors
Takuji TANAKA1),2),3), Toshiya KUNO1), Akira HARA1), Yoshinobu HIROSE1)
1)Department of Tumor Pathology, Gifu University Graduate School of Medicine, 2)Department of Oncologic Pathology, Kanazawa Medical University, 3)Tohkai Cytopathology Institute: Cancer Research and Prevention (TCI-CaRP)
Journal of Toxicologic Pathology 25 (suppl) 55-55, 2012.
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P-085 Histopathological Characteristics of Adenomatous Hyperplasia of Glandular Gastric Mucosa in Untreated and Vehicle Treated ICR (CD1) Mice
Shigeaki TAKAMI, Atsushi SHIGA, Kazushige HASEGAWA, Masayo HOSOI, Rumiko MIYAJIMA, Yoshihide UEDA, Yasufumi OTA, Isao NARAMA
BSRC
Journal of Toxicologic Pathology 25 (suppl) 55-55, 2012.
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P-086 Induction of p21 at Intestinal Crypt Bottom in X-Irradiated Mice
Tetsuya TSUKAMOTO
Dept.Diag.Pathol., Fujita Health Univ.Sch.Med.
Journal of Toxicologic Pathology 25 (suppl) 56-56, 2012.
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P-087 Brunner's Gland Lesions in Rats Induced by A Vascular Endothelial Growth Factor Receptor Inhibitor
Akira Inomata1), Kyoko Nakano1), Yasuhiro Fujikawa1), Jiro Sonoda1), Kazuhiro Hayakawa2), Etsuko Ota1), Yoshikazu Taketa1), Yuki Seki1), Aya Goto1), Yvonne Van Gessel3), Sandeep Akare3), David Hutto3), Satoru Hosokawa1), Kazuo Tsukidate1)
1)Drug Safety Tsukuba, Eisai Co., Ltd., 2)Preclinical Safety Research Laboratories, Kawashima Division, Sunplanet Co., Ltd., 3)Drug Safety Andover, Eisai Co., Ltd.
Journal of Toxicologic Pathology 25 (suppl) 56-56, 2012.
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P-088 Particokinetics and Extrapulmonary Translocation of Intratracheally Instilled Triiron Tetraoxide Nanoparticles (Magnetite)
Yukie TADA1), Ikue SAITO1), Norio YANO1), Hiroshi TAKAHASHI1), Katsuhiro YUZAWA1), Hiroshi ANDO1), Yoshikazu KUBO1), Akemichi NAGASAWA1), Ken-ichi OHYAMA1), Akio OGATA1), Dai NAKAE1),2)
1)Tokyo Metropolitan Institute of Public Health, 2)Tokyo University of Agriculture
Journal of Toxicologic Pathology 25 (suppl) 57-57, 2012.
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P-089 Promotion Effects of Rat Lung Carcinogenesis of Fullerene (C60) administered by intra-pulmonary spraying
Katsumi FUKAMACHI1), Mitsuru FUTAKUCHI1), Jiegou XU1),2), Yoshiyuki INOUE3), Mineo TAKATSUKI3), Hiroyuki TSUDA2), Masumi Suzui1)
1)Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 2)Nanotoxicology project, Nagoya City University, 2)Chemicals Evaluation and Research Institute
Journal of Toxicologic Pathology 25 (suppl) 57-57, 2012.
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P-090 Alveolar hyperplasia like lesions induced by intra tracheal spray of carbon black particles.
Mitsuru FUTAKUCHI1), Jegou XU1),2), Yoshiyuki INOUE3), Mineo TAKATSUKI3), Hiroyuki TSUDA2), Suzui MASUMI1)
1)Department of Molecular Toxicology, Nagoya City University, 2)Laboratory of Nanotoxicology Project, Nagoya City University, 3)Chemical Evaluation and Research Institute
Journal of Toxicologic Pathology 25 (suppl) 58-58, 2012.
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P-091 The reactions to potassium octatitanate fibers (TISMO) administrated to left thoracic cavity in A/J female mice.
Masanao YOKOHIRA1), Nozomi HASHIMOTO1), Yuko NAKANO1), Keiko YAMAKAWA1), Tatsushi INOUE1), Sosuke KISHI1), Fumiko NINOMIYA1), Kousuke SAOO2), Katsumi IMAIDA1)
1)Onco-pathology, Faculty of Medicine, Kagawa University, 2)Diagnostic Pathology, Kaisei General Hospital
Journal of Toxicologic Pathology 25 (suppl) 58-58, 2012.
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P-092 Multi-walled Carbon Nanotubes Translocate into the Pleural Cavity and Cause Mesothelial Proliferation
Jiegou Xu1), Mitsuru Futakuchi2), Hideo Shimizu3), David B.Alexander1), Katsumi Fukamachi2), Kazuyoshi Yanagihara4), Masumi Suzui2), Jun Kanno5), Akihiko Hirose5), Hiroyuki Tsuda1)
1)Laboratory of Nanotoxicology Project, Nagoya City University, 2)Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, 3)Core Laboratory, Nagoya City University Graduate School of Medical Sciences, 4)Department of Life Sciences, Yasuda Women's University Faculty of Pharmacy, 5)National Institute of Health Sciences
Journal of Toxicologic Pathology 25 (suppl) 59-59, 2012.
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P-093 Influence of the product level physicochemical property on the carcinogenicity of multi-wall carbon nanotube in rats
Yoshimitsu Sakamoto1), Akio Ogata1), Tomokazu Maeno1), Tetsuji Nishimura3), Akihiko Hirose4), Kenichi Ohyama1), Dai Nakae2),5)
1)Dept.Environ.Health, Tokyo Metropol.Inst.Pub.Health, 2)Dept.Pharm.Sci., Tokyo Metropol.Inst.Pub.Health, 3)Div.Environ.Chem., NIHS, 4)Div.Risk.Assessment, NIHS, 5)Tokyo Univ.Agricul.
Journal of Toxicologic Pathology 25 (suppl) 59-59, 2012.
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P-094 The strain difference for the effect of chronic inflammation to lung carcinogenesis in F344 and Wistar-Hannover rats
Yuko NAKANO1), Masanao YOKOHIRA1), Nozomi HASHIMOTO1), Keiko YAMAKAWA1), Tatsushi INOUE1), Sosuke KISHI1), Fumiko NINOMIYA1), Kousuke SAOO1),2), Katsumi IMAIDA1)
1)Onco-pathology, Faculty of Medicine, Kagawa University, 2)Diagnostic Pathology, Kaisei General Hospital
Journal of Toxicologic Pathology 25 (suppl) 60-60, 2012.
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P-095 4-Nitroquinoline 1-Oxide Induced Pulmonary Tumorigenesis in TSOD Mice
Toshiya Kuno1), Takuji Tanaka1),2), Yoshinobu Hirose1), Akira Hara1)
1)Dept.Tumor Pathol., Graduate Sch.Med., Gifu Univ., 2)TCI-CaRP
Journal of Toxicologic Pathology 25 (suppl) 60-60, 2012.
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P-096 Laccaic Acid in Lac Color Targets Plasma Hyaluronan-binding Protein (PHBP) and Inhibits Induction of Thyroid Capsular Invasive Carcinomas in Rats
Sayaka KEMMOCHI1),2), Atsunori YAFUNE1),2), Hirotoshi AKANE1), Reiko MORITA1),2), Keiji HASUMI3), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab.Vet.Pathol., Tokyo Univ.Agricul.Technol., 2)Pathogen.Vet.Sci., United Grad.Sch.of Vet.Sci., Gifu Univ., 3)Lab.Fermentat., Tokyo Univ.Agricul.Technol.
Journal of Toxicologic Pathology 25 (suppl) 61-61, 2012.
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P-097 A 28-day repeated dose study of glycidol, 3-MCPD and associated esters in rats.
Saeko ONAMI1), Young-man CHO1), Takeshi TOYODA1), Katsuyoshi HORIBATA2), Masamitsu HONMA2), Takehiko NOHMI2), Akiyoshi NISHIKAWA3), Kumiko OGAWA1)
1)Division of Pathology, National Institute of Health Science, 2)Division of Genetics and Mutagenesis, National Institute of Health Science, 3)Biological Safety Research Center, National Institute of Health Science
Journal of Toxicologic Pathology 25 (suppl) 61-61, 2012.
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P-098 Application of Renal Carcinogen-responding Markers to Other Carcinogenic Target Organs in Rats Treated with Carcinogens Targeting Other Organs for 28 Days
Eriko TANIAI1),2), Atsunori YAFUNE1),2), Reiko MORITA1),2), Hirotoshi AKANE1), Hitomi HAYASHI1),2), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab.Vet.Pathol., Tokyo Univ.Agricul.Technol., 2)Pathog.Vet.Sci., United Grad.Sch.Vet.Sci., Gifu Univ.
Journal of Toxicologic Pathology 25 (suppl) 62-62, 2012.
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P-099 Expression Characteristics of Cell Cycle-related Molecules in The Liver of Rats Treated with Hepatocarcinogens for 28 Days
Atsunori YAFUNE1),2), Eriko TANIAI1),2), Hitomi HAYASHI1),2), Reiko MORITA1),2), Sayaka KEMMOCHI1),2), Liyun WANG1), Kazuhiko SUZUKI1), Kunitoshi MITSUMORI1), Makoto SHIBUTANI1)
1)Lab.Vet.Pathol., Tokyo Univ.Agricul.And Technol., 2)Pathogen.Vet.Sci., United Grad.Sch.Vet.Sci., Gifu University
Journal of Toxicologic Pathology 25 (suppl) 62-62, 2012.
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P-100 Rat 90-Day Repeated Oral Toxicity Study of Peach Gum
Yuko DOI1), Mayumi KAWABE1), Norio IMAI1), Mayuko SUGURO1), Midori YOSHIDA2), Kumiko OGAWA2), Akiyoshi NISHIKAWA2)
1)DIMS Institute of Medical Science, Inc., 2)National Institute of Health Sciences, Division of Pathology
Journal of Toxicologic Pathology 25 (suppl) 63-63, 2012.
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P-101 A 90 day Feeding Toxicity Study of Magnesium Hydrogen Phosphate (MgHPO4.3H2O) in Sprague-Dawley rats.
Takamasa NUMANO1), Akihiro HAGIWARA1), Hironao NAKASHIMA1), Seiko TAMANO1), Fumio FURUKAWA1), Yuhji TAQUAHASHI2), Jun KANNO2)
1)DIMS Institute of Medical Science, Inc., 2)Division of Cellular and Molecular Toxicology, Biological Safety Research Center, National Institute of Health Science
Journal of Toxicologic Pathology 25 (suppl) 63-63, 2012.
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P-102 Can a carcinogenicity of a pharmaceutical be predicted without a rat 2-year carcinogenicity study? - The analysis of data collected from package inserts of pharmaceuticals in Japan
Mizuho Nonaka1), Yukie Saegusa1), Kohei Amakasu1), Osamu Fueki1), Hiroshi Onodera1), Kumiko Ogawa2), Akiyoshi Nishikawa2), Dai Nakae3)
1)PMDA, 2)NIHS, 3)Dept.Pharm.Sci., Tokyo Metropol.Inst.Pub.Health
Journal of Toxicologic Pathology 25 (suppl) 64-64, 2012.
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P-103 Nasal Lesion in Rats Exposed to 2,4-pentanedione for 13-weeks and 104-weeks
Yumi UMEDA1), Kenji TAKANOBU1), Hideki SENOH1), Taku KATAGIRI1), Shigetoshi AISO1), Kasuke Nagano2), Shoji FUKUSHIMA1)
1)Japan Bioassay Research Center, Japan Industrial Safety and Health Association (JISHA), 2)Former Japan Bioassay Research Center, JISHA
Journal of Toxicologic Pathology 25 (suppl) 64-64, 2012.
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P-104 A Chronic Toxicity Study of Acrylamide in Hamsters
Toshio IMAI1), Takuya HAYAKAWA2), Kazuo KANNO3), Masami ISHII3), Akiyoshi NISHIKAWA4)
1)Central Anim.Div., Natl.Cancer Center Res.Inst., 2)Div.Cancer Prev.Res., Natl.Cancer Center Res.Inst., 3)Pathol.Group, Histo Sci.Lab., 4)Biol.Safety Res.Center, Natl.Inst.of Health Sci.
Journal of Toxicologic Pathology 25 (suppl) 65-65, 2012.
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P-105 A Carcinogenicity Study of Semicarbazide Hydrochloride Administered in The Diet to B6C3F1 Mice
Young-Man CHO1), Takeshi TOYODA1), Saeko ONAMI1), Shigeaki TAKAMI1), Toshio IMAI3), Kumiko OGAWA1), Akiyoshi NISHIKAWA2)
1)Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, 2)Biological Safety Research Center, National Institute of Health Sciences, 3)Central Animal Division, National Cancer Center Research Institute
Journal of Toxicologic Pathology 25 (suppl) 65-65, 2012.
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P-106 Background Data for Carcinogenicity Studies in RccHanTM: WIST Rats
Osamu KUSUOKA, Toru HOSHIYA, Yuko YAMAGUCHI, Atsushi NAKAMURA, Toshiya OKAMURA, Shuzo OKAZAKI, Kazutoshi TAMURA
BOZO Research Center Inc.
Journal of Toxicologic Pathology 25 (suppl) 66-66, 2012.
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P-107 Long Term Husbandry in House Background Data of Wistar-Hannover Rats
Seiji Miyoshi, Hirofumi Hatakeyama, Yoshihiro Takei, Jun Watanabe, Kunihiko Oishi, Takashi Shibano, Haruko Koizumi, Mitsutoshi Watanabe, Akihito Shimoi
Ina Research, Inc.Research Center
Journal of Toxicologic Pathology 25 (suppl) 66-66, 2012.
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P-108 Natural Occurrence of Neoplastic and Preneoplastic Lesions in Young Sprague-Dawley Rats
Isamu SUZUKI, Shinichiro IKEZAKI, Mizuho TAKAGI, Kayoko KUDO, Keita MATSUSHIMA, Seiki YAMAKAWA, Kazutoshi TAMURA
Pathology Department, BOZO Research Center Inc.
Journal of Toxicologic Pathology 25 (suppl) 67-67, 2012.
  • 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
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