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Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests : a collaborative study by MMS / JEMS
Manabu Yasui1, Takayuki Fukuda2, Akiko Ukai1, Jiro Maniwa3, Tadashi Imamura4, Tsuneo Hashizume5, Haruna Yamamoto5, Kaori Shibuya5, Kazunori Narumi6, Yohei Fujiishi6, Emiko Okada6, Saori Fujishima7, Mika Yamamoto8, Naoko Otani8, Maki Nakamura2, Ryoichi Nishimura2, Maya Ueda9, Masayuki Mishima10, Kaori Matsuzaki10, Akira Takeiri10, Kenji Tanaka10, Yuki Okada11, Munehiro Nakagawa12, Shuichi Hamada2, Akihiko Kajikawa12, Hiroshi Honda13, Jun Adachi14, Kentaro Misaki15, Kumiko Ogawa16, Masamitsu Honma1
1Division of Genetics and Mutagenesis, National Institute of Health Sciences, 2Tokyo Laboratory, BoZo Research Center Inc., 3AstraZeneca KK, 4Ina Research Inc., 5Scientific Product Assessment Center, R&D Group, 6Yakult Central Institute, 7Chemicals Evaluation and Research Institute, Japan, 8Astellas Pharma Inc., 9Genotoxicology Laboratory, BioSafety Research Center Inc., 10Chugai Pharmaceutical Co., Ltd, 11Toxicology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, 12Nonclinical Research Center, LSI Medience Corporation, 13R&D Safety Science Research, Kao Corporation, 14Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, 15School of Nursing, University of Shizuoka, 16Division of Pathology, National Institute of Health Sciences
Genes and Environment 43 (7) 1-19, 2021.
1Division of Genetics and Mutagenesis, National Institute of Health Sciences, 2Tokyo Laboratory, BoZo Research Center Inc., 3AstraZeneca KK, 4Ina Research Inc., 5Scientific Product Assessment Center, R&D Group, 6Yakult Central Institute, 7Chemicals Evaluation and Research Institute, Japan, 8Astellas Pharma Inc., 9Genotoxicology Laboratory, BioSafety Research Center Inc., 10Chugai Pharmaceutical Co., Ltd, 11Toxicology Research Department, Teijin Institute for Bio-medical Research, Teijin Pharma Limited, 12Nonclinical Research Center, LSI Medience Corporation, 13R&D Safety Science Research, Kao Corporation, 14Laboratory of Proteomics for Drug Discovery, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, 15School of Nursing, University of Shizuoka, 16Division of Pathology, National Institute of Health Sciences
Genes and Environment 43 (7) 1-19, 2021.
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