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S1-1 Gene Expression Changes in vivo/in vitro Induced by Mutagens
Takayoshi Suzuki
Div. Cellular and Gene Therapy Products, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 212-212, 2006.
Div. Cellular and Gene Therapy Products, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 212-212, 2006.
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S1-2 Evaluation of carcinogenicity on chemicals using transgenic mice
Kunitoshi Mitsumori1), Miwa Okamura1), Meilan Jin1)
1)Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Alternatives to Animal Testing and Experimentation 11 (suppl) 213-213, 2006.
1)Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
Alternatives to Animal Testing and Experimentation 11 (suppl) 213-213, 2006.
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S1-3 Establishment of humanized genotoxicity test system and its application to genotoxic and carcinogenic risk assessment
Masamitsu Honma
National Institute of Health Sciences, Division of Genetics and Mutagenesis
Alternatives to Animal Testing and Experimentation 11 (suppl) 214-214, 2006.
National Institute of Health Sciences, Division of Genetics and Mutagenesis
Alternatives to Animal Testing and Experimentation 11 (suppl) 214-214, 2006.
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S1-4 Chemical compound profiling based on proteomics technology
H Yamanaka1), Y Sudo1), Y Yakabe1), K Saito2), K Sumida2), M Sekijima3), K Nakayama3), T Shirai4)
1)Chemicals Evaluation and Research Institute, Sumitomo Chemical Co. , Ltd., 2)Mitsubishi Chemical Safety Institute Ltd, ., 3)Graduate School of Medical Sciences, 4)Nagoya City Univ.
Alternatives to Animal Testing and Experimentation 11 (suppl) 215-215, 2006.
1)Chemicals Evaluation and Research Institute, Sumitomo Chemical Co. , Ltd., 2)Mitsubishi Chemical Safety Institute Ltd, ., 3)Graduate School of Medical Sciences, 4)Nagoya City Univ.
Alternatives to Animal Testing and Experimentation 11 (suppl) 215-215, 2006.
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S1-5 Detection of tumor initiators and promoters using Bhas 42 cells
Shin Asada, Kiyoshi Sasaki, Noriho Tanaka, Makoto Umeda
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 216-216, 2006.
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 216-216, 2006.
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S1-6 The present status of prevalidation study in ECVAM on alternative methods for screening carcinogenic chemicals
Makoto Umeda, Kiyoshi Sasaki, Noriho Tanaka
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 217-217, 2006.
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 217-217, 2006.
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S2-1 The Forefront of Alternatives to Animal Testing:the Search for a Breakthrough in In Vitro Toxicology
Atsushige Sato1), Hiroshi Itagaki2)
1)Department of Oral Biomaterials and Technology, Showa University School of Dentistry, 2)Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 218-218, 2006.
1)Department of Oral Biomaterials and Technology, Showa University School of Dentistry, 2)Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 218-218, 2006.
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S2-2 Development of in vitro alternative assays for acute systemic toxicity, and skin genotoxicity test in vivo
Noriho Tanaka1), Hiroshi Itagaki2), Shinobu Wakuri1), Masato Kitagaki2), Yuzuki Nakagawa1)
1)Hatano Research Institute, Food and Drug Safety Center, 2)Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 219-219, 2006.
1)Hatano Research Institute, Food and Drug Safety Center, 2)Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 219-219, 2006.
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S2-3 Prediction of skin permeability of compounds from their molecular structure
Fumiyoshi Yamashita1), Hirokazu Kouzuki2), Hiroshi Itagaki2), Mitsuru Hashida1)
1)Graduate School of Pharmaceutical Sciences, Kyoto University, 2)Safety and Analytical Research Center, Shiseido Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 220-220, 2006.
1)Graduate School of Pharmaceutical Sciences, Kyoto University, 2)Safety and Analytical Research Center, Shiseido Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 220-220, 2006.
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S2-4 Evaluation of Drug-metabolizing Capacities of Cell Lines Using for Alternative Sensitization Tests
Takemi Yoshida, Takashi Ashino, Makie Ishikawa, Satoshi Numazawa
Dept. Biochem. Toxicol. , Sch. Pharmaceut. Sci. , Showa University
Alternatives to Animal Testing and Experimentation 11 (suppl) 221-221, 2006.
Dept. Biochem. Toxicol. , Sch. Pharmaceut. Sci. , Showa University
Alternatives to Animal Testing and Experimentation 11 (suppl) 221-221, 2006.
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S2-5 Unresolved questions regarding sensitization by haptens
Setsuya Aiba, Satoshi Nakagawa, Masato Mizuashi, Tomohiro Ohtani, Ikuko Numata
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 222-222, 2006.
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 222-222, 2006.
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S2-6 Development of an in vitro skin sensitization test (human Cell Line Activation Test; h-CLAT) using THP-1 cell (human monocytic leukemia cell line)
Takao Ashikaga
Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 223-223, 2006.
Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 223-223, 2006.
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F-1 The situation of introduction of alternatives in the world
Eriko Gotoh
InterNICHE
Alternatives to Animal Testing and Experimentation 11 (suppl) 224-224, 2006.
InterNICHE
Alternatives to Animal Testing and Experimentation 11 (suppl) 224-224, 2006.
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F-2 Proposal for Animal Body Donation Program in higher education in Japan
Lee, Kenichi1), 2)
1)Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 2) Animal Donation Network
Alternatives to Animal Testing and Experimentation 11 (suppl) 225-225, 2006.
1)Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 2) Animal Donation Network
Alternatives to Animal Testing and Experimentation 11 (suppl) 225-225, 2006.
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F-3 Considering About An Anatomy Practice in The Academic Education (in Mainly Veterinary Section) 〜Aiming at the fulfillment of animal donation system 〜
Daisuke Nagaosa
Department of Veterinary Medicine, Azabu University
Alternatives to Animal Testing and Experimentation 11 (suppl) 226-226, 2006.
Department of Veterinary Medicine, Azabu University
Alternatives to Animal Testing and Experimentation 11 (suppl) 226-226, 2006.
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F-4 THE VETERINARY SURGERY TRAINING 〜The present state and problem〜
Kaisaku OTA1), 2)
1) Department of Veterinary Medicine, Kitasato University, 2) Animal Donation Network
Alternatives to Animal Testing and Experimentation 11 (suppl) 227-227, 2006.
1) Department of Veterinary Medicine, Kitasato University, 2) Animal Donation Network
Alternatives to Animal Testing and Experimentation 11 (suppl) 227-227, 2006.
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S3-1 Cutaneous allergy
Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 228-228, 2006.
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 228-228, 2006.
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S3-2 Integrating in vitro data into skin sensitization risk assessments
David Basketter
Safety and Environmental Assurance Centre
Alternatives to Animal Testing and Experimentation 11 (suppl) 228-228, 2006.
Safety and Environmental Assurance Centre
Alternatives to Animal Testing and Experimentation 11 (suppl) 228-228, 2006.
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S3-3 LLNA-DA and LLNA-BrdU
Yukiko Kanazawa
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 229-229, 2006.
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 229-229, 2006.
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S3-4 Cell-based in vitro skin sensitization methods
Hitoshi Sakaguchi
Kao Corporation, Safety and Microbial Control Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 230-230, 2006.
Kao Corporation, Safety and Microbial Control Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 230-230, 2006.
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S3-5 Hapten-protein/peptide binding assay as a screening method for skin sensitiztaion
Yosuke Nakamura
Sumitomo Chemical, Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 231-231, 2006.
Sumitomo Chemical, Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 231-231, 2006.
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S3-6 Convenient in-silico Toxicity assessment via TOPKAT
Takeshi Saito
Accelrys KK.
Alternatives to Animal Testing and Experimentation 11 (suppl) 231-231, 2006.
Accelrys KK.
Alternatives to Animal Testing and Experimentation 11 (suppl) 231-231, 2006.
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S3-7 Prediction for skin sensitization using Derek for Windows
Hiroko Akiyama
CTC Laboratory Systems Corporation, Life Science Technology Dept.
Alternatives to Animal Testing and Experimentation 11 (suppl) 232-232, 2006.
CTC Laboratory Systems Corporation, Life Science Technology Dept.
Alternatives to Animal Testing and Experimentation 11 (suppl) 232-232, 2006.
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P-01 Studies on the prediction of photochemical carcinogenesis induced by quinolone antimicrobial agents
Kenji Inoue, Riichirou Yonezawa, Katsuaki Kubota
Maruho Co. , Ltd. Research Laboratories
Alternatives to Animal Testing and Experimentation 11 (suppl) 233-233, 2006.
Maruho Co. , Ltd. Research Laboratories
Alternatives to Animal Testing and Experimentation 11 (suppl) 233-233, 2006.
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P-02 Inter-laboratory Collaborative Study of Cell Transformation Assay for Tumor Promoters Using Bhas 42 cells by Non-genotoxic Carcinogen Study Group in Japan
Kiyomi Ohmori 1), Makoto Umeda 2), Noriho Tanaka 2), Hiroki Takagi 3), Isao Yoshimura 4), Kiyoshi Sasaki 2), Shin Asada 2), Ayako Sakai 5), Masumi Asakura 7), Hiroshi Baba 8), Yuichi Fushiwaki 1), Shuichi Hamada 9), Nobuko Kitou 6), Tetsu Nakamura 10), Yoshiyuki Nakamura 11), Hidetoshi Oishi 12), Satoshi Sasaki 13), Sawako Shimada 14), Toshiyuki Tsuchiya 15), Yoshifumi Uno 8), Masataka Washizuka 16), Satoshi Yajima 13), Yasuhito Yamamoto 17), Eiji Yamamura 8), Tomoko Yatsushiro 10)
1) Kanagawa Prefectural Institute of Public Health, 2) Food and Drug Safe Center, 3) Aventis Pharma Ltd., 4) Tokyo University of Science, 5) National Institute of Health Sciences, 6) Toyama Chemical Co. Ltd., 7) Japan Bioassay Research Center, 8) Mitsubishi Pharma Corporation, 9) Mitsubishi Chemical Safety Institute Ltd., 10) Canon Inc., 11) Sugiyama Jogakuen University, 12) Dainippon Pharmaceutical Co. Ltd., 13) Takasago International Corporation, 14) Biosafety Research Center, Foods, Drus and Pesticides, 15) Banyu Pharmaceutical Co. Ltd, 16) Zeria Pharmaceutical Co. Ltd., 17) LION Corporation
Alternatives to Animal Testing and Experimentation 11 (suppl) 234-234, 2006.
1) Kanagawa Prefectural Institute of Public Health, 2) Food and Drug Safe Center, 3) Aventis Pharma Ltd., 4) Tokyo University of Science, 5) National Institute of Health Sciences, 6) Toyama Chemical Co. Ltd., 7) Japan Bioassay Research Center, 8) Mitsubishi Pharma Corporation, 9) Mitsubishi Chemical Safety Institute Ltd., 10) Canon Inc., 11) Sugiyama Jogakuen University, 12) Dainippon Pharmaceutical Co. Ltd., 13) Takasago International Corporation, 14) Biosafety Research Center, Foods, Drus and Pesticides, 15) Banyu Pharmaceutical Co. Ltd, 16) Zeria Pharmaceutical Co. Ltd., 17) LION Corporation
Alternatives to Animal Testing and Experimentation 11 (suppl) 234-234, 2006.
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P-03 Effects of polychlorinated biphenyls on cultured rat embryos
Masaharu Akita1), Mari Kato1), Atsushi Yokoyama2), Koichi Haraguchi3), Nobuyuki Koga4), Yukiaki Kuroda5)
1)Kamakura Women's University, 2)Kanagawa Life Science Research Laboratory, 3)Daiichi College of Pharmaceutical Science, 4)Nakamura Gakuen University, 5)National Institute of Genetics
Alternatives to Animal Testing and Experimentation 11 (suppl) 235-235, 2006.
1)Kamakura Women's University, 2)Kanagawa Life Science Research Laboratory, 3)Daiichi College of Pharmaceutical Science, 4)Nakamura Gakuen University, 5)National Institute of Genetics
Alternatives to Animal Testing and Experimentation 11 (suppl) 235-235, 2006.
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P-04 Effects of Kalesite (KS) used as a conjugated drug with environmental chemical on cultured rat embryos
A. Yokoyama1), H. Yokoyama2), E. A. Johnston2), M. Akita3), Yukiaki Kuroda4)
1)Kanagawa Life-science Research, 2)Baltimore Environmental Science Research, 3)Kamakura Women's University, 4)National Institute of Genetics
Alternatives to Animal Testing and Experimentation 11 (suppl) 235-235, 2006.
1)Kanagawa Life-science Research, 2)Baltimore Environmental Science Research, 3)Kamakura Women's University, 4)National Institute of Genetics
Alternatives to Animal Testing and Experimentation 11 (suppl) 235-235, 2006.
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P-05 Novel protocol for evaluation of respiratory sensitizers: -Availability for chemical materials-
Yamagishi Gaku1), Aoyama Kohji2), Idehara Kenji1), Uemori Takeshi1), Takeuchi Toru2), Yamashita Kunihiko1)
1)Daicel Chemical Industries, Ltd. Analysis Service Center, 2)Dept Envir Med, Gradu Sch Med Dent Sci, Kagoshima Univ
Alternatives to Animal Testing and Experimentation 11 (suppl) 236-236, 2006.
1)Daicel Chemical Industries, Ltd. Analysis Service Center, 2)Dept Envir Med, Gradu Sch Med Dent Sci, Kagoshima Univ
Alternatives to Animal Testing and Experimentation 11 (suppl) 236-236, 2006.
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P-06 Novel protocol for evaluation of respiratory sensitizers: Quantitative evaluation
Kohji Aoyama1), Gaku Yamagishi2), Kenji Idehara2), Takeshi Uemori2), Baohui Xu3), Toru Takeuchi1), Kunihiko Yamashita2)
1) Dept Environ, Gradu Sch Med Dent Sci, Kagoshima Univ, 2) Daicel Chemical Industries, Ltd. Analysis Service Center, 3) Dept Pathol, Sch Med, Stanford Univ
Alternatives to Animal Testing and Experimentation 11 (suppl) 237-237, 2006.
1) Dept Environ, Gradu Sch Med Dent Sci, Kagoshima Univ, 2) Daicel Chemical Industries, Ltd. Analysis Service Center, 3) Dept Pathol, Sch Med, Stanford Univ
Alternatives to Animal Testing and Experimentation 11 (suppl) 237-237, 2006.
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P-07 Results of a Japanese ring study of a Human Cell Line Activation Test (h-CLAT) for predicting skin sensitization potential (1st report)
Ashikaga Takao1), Sakaguchi Hitoshi2), Okamoto Kenji3), Mizuno Makoto4), Yamada Takaaki5), Yoshida Mayumi6), Sato Jun7), Kodama Tatsuji7), Ohta Naoko6), Hasegawa Seiji5), Okamoto Yuko4), Kuwahara Hirofumi3), Kosaka Nanae2), Sono Sakiko1), Ohno Yasuo8)
1) Shiseido Co. , Ltd., 2) Kao Corporation, 3) Kanebo Cosmetic Inc., 4) KOSE Corporation, 5) Nippon Menard Cosmetic Co. , Ltd., 6) POLA CHEMICAL INDUSTORIES, INC., 7) LION CORPORATION, 8) National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 238-238, 2006.
1) Shiseido Co. , Ltd., 2) Kao Corporation, 3) Kanebo Cosmetic Inc., 4) KOSE Corporation, 5) Nippon Menard Cosmetic Co. , Ltd., 6) POLA CHEMICAL INDUSTORIES, INC., 7) LION CORPORATION, 8) National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 238-238, 2006.
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P-08 Study on optimization of in vitro sensitization assay using THP-1cells
Sakiko Sono, Kasturako Yoneyama, Takao Ashikaga, Hiroshi Itagaki
Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 239-239, 2006.
Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 239-239, 2006.
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P-09 Evaluation of changes of cell surface thiols as a new biomarker for in vitro sensitization (I): The accuracy of in vitro assay vs. in vivo assay
Mie Suzuki1), Morihiko Hirota1), Shigenobu Hagino1), Hiroshi Itagaki1), Setsuya Aiba2)
1) Shiseido Safety and Analytical Research Center, 2) Department Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 240-240, 2006.
1) Shiseido Safety and Analytical Research Center, 2) Department Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 240-240, 2006.
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P-10 Evaluation of changes of cell surface thiols as a new biomarker for in vitro sensitization assay (II): the comparison between cell lines.
Morihiko Hirota1), Mie Suzuki1), Shigenobu Hagino1), Hiroshi Itagaki1), Setsuya Aiba2)
1) Shiseido Safety and Analytical Research Center, 2) Department Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 241-241, 2006.
1) Shiseido Safety and Analytical Research Center, 2) Department Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 241-241, 2006.
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P-11 The cross-link between the reduced cell surface thiols and the oxidized GSH/GSSG ratio in monocyte-derived dendritic cells treated with haptens
Yosinori Sasaki1), Masato Mizuashi1), Morihiko Hirota2), Mie Suzuki2), Hiroshi Itagaki2), Setsuya Aiba1)
1) Department Dermatology, Tohoku University Graduate School of Medicine, 2) Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 242-242, 2006.
1) Department Dermatology, Tohoku University Graduate School of Medicine, 2) Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 242-242, 2006.
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P-12 Development of a peptide binding assay for predicting contact dermatitis.
Hoya M., Kanda K., Kouzuki H., Hagino S., Itagaki H.
Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 243-243, 2006.
Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 243-243, 2006.
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P-13 Skin sensitization test with human monocytic leukemia cell line in fragrances
Yoshikazu Naoe, Makoto Mizuno, Noriyasu Imai, Miki Nakanishi, Kei Kusai, Yuko Okamoto
KOSE Corporation Fundamental Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 244-244, 2006.
KOSE Corporation Fundamental Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 244-244, 2006.
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P-14 The response pattern of THP-1 cells to allergens and mechanisms of allergen-induced THP-1 cell activation
Masaaki Miyazawa, Yuichi Ito, Nanae Kosaka, Hitoshi Sakaguchi, Hiroyuki Suzuki
Kao Corporation, Safety and Microbial Control Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 245-245, 2006.
Kao Corporation, Safety and Microbial Control Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 245-245, 2006.
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P-15 Role of mitogen-activated protein kinase in CD86/CD54 expression induced by contact sensitizers on THP-1 cells
Yuichi Ito, Masaaki Miyazawa, Yukiko Yoshida, Nanae Kosaka, Hitoshi Sakaguchi, Hiroyuki Suzuki
Kao Corporation, Safety and Microbial Control Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 246-246, 2006.
Kao Corporation, Safety and Microbial Control Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 246-246, 2006.
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P-16 Investigation of co-stimulatory molecules expression and cytokines production in THP-1 human monocyte cell line treated with skin sensitizers
Makoto Mizuno, Noriyasu Imai, Miki Nakanishi, Yoshikazu Naoe, Kei Kusai, Yuko Okamoto
KOSE Corporation Fundamental Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 247-247, 2006.
KOSE Corporation Fundamental Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 247-247, 2006.
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P-17 Evaluation of Drug-metabolizing Capacities of Cell Lines Using for Alternative Tests - with Special Reference to Alterenative Sensitization Test
Takemi Yoshida1), Takashi Ashino1), Makie Ishikawa1), Masaaki Mori2), Shigenobu Hagino2), Hiroshi Itagaki2), Satoshi Numazawa1)
1) Dept. Biochem. Toxicol. , Sch. Pharmaceut. Sci. , Showa University, 2) Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 248-248, 2006.
1) Dept. Biochem. Toxicol. , Sch. Pharmaceut. Sci. , Showa University, 2) Shiseido Safety and Analytical Research Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 248-248, 2006.
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P-18 Construction of three-dimensional human skin model consisting of dendritic cells, keratinocytes and fibroblasts
Tadashi Uchino, Hiroshi Tokunaga
Division of Environmental Chemistry, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 249-249, 2006.
Division of Environmental Chemistry, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 249-249, 2006.
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P-19 Reproducibility of human 3-dimensional cultured epidermal model (LabCyte EPI-MODEL) for an alternative to animal testing
Kubo Kentaro, Kuchiike Daisuke, Shigeta Tomomi, Hamajima Fumiyasu, Katoh Masakazu
Japan Tissue Engineering Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 250-250, 2006.
Japan Tissue Engineering Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 250-250, 2006.
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P-20 The morphological and functional study of human 3-dimensional cultured epidermal model (LabCyte EPI-MODEL) -Evaluation of proliferation, differentiation and secreted cytokines-
Hamajima Fumiyasu, Kubo Kentaro, Katoh Masakazu, Hata Ken-ichiro
Japan Tissue Engineering Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 251-251, 2006.
Japan Tissue Engineering Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 251-251, 2006.
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P-21 Skin irritant tests using human 3-dimensional cultured epidermal model (LabCyte EPI-MODEL) -Analysis by inflammatory cytokines-
Hamajima Fumiyasu, Kubo Kentaro, Katoh Masakazu, Hata Ken-ichiro
Japan Tissue Engineering Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 252-252, 2006.
Japan Tissue Engineering Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 252-252, 2006.
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P-22 Evaluation of skin irritation using cultured cells -Effect of skin concentration and applied period on the skin irritation-
Yoshifumi Takinoue1), Hiroshi Ishii1), Satoshi Kano2), Hiroaki Todo1), Kenji Sugibayashi1)
1) Graduate School of Pharmaceutical Sciences, Josai University, 2) Kyoto R&D Center, Maruho Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 253-253, 2006.
1) Graduate School of Pharmaceutical Sciences, Josai University, 2) Kyoto R&D Center, Maruho Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 253-253, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-23 In vitro micronucleus test using rat FRSK cells.
Yuzuki Nakagawa, Noriho Tanaka
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 254-254, 2006.
Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 254-254, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-24 Vitrigel-sandwich culture system useful for maintaining the functions of rat primary hepatocytes
Yukiko NAKAZAWA1, 2, Koichi UENO2, Toshiaki TAKEZAWA1
1Laboratory of Animal Cell Biology, National Institute of Agrobiological Sciences, 2Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 11 (suppl) 255-255, 2006.
1Laboratory of Animal Cell Biology, National Institute of Agrobiological Sciences, 2Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 11 (suppl) 255-255, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-25 Development of a new three-dimensional culture of human hepatocytes
Tatsuya Yamaguchi1, Takuya Ishibashi1, Kouji Nakazawa2, Hiroshi Mizumoto3, Kazumori Funatsu4
1)TM Cell Research Inc., 2)University of Kitakyushu, 3)Kyushu University, 4)Kyushu University
Alternatives to Animal Testing and Experimentation 11 (suppl) 256-256, 2006.
1)TM Cell Research Inc., 2)University of Kitakyushu, 3)Kyushu University, 4)Kyushu University
Alternatives to Animal Testing and Experimentation 11 (suppl) 256-256, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-26 Gene Expression Analysis of Liver Cells in Double-layered Coculture Systems with Small Intestinal Cells in the Presence of Xenobiotics
Masaki Nishikawa1), Nobuhiko Kojima1), Emiko Kitagawa2), Hitoshi Iwahashi2), Takatoki Yamamoto1), Teruo Fujii1), Yasuyuki Sakai1), 3)
1)Institute of Industrial Science, University of Tokyo, 2)National Institute of Advanced Industrial Science and Technology, 3)Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo
Alternatives to Animal Testing and Experimentation 11 (suppl) 257-257, 2006.
1)Institute of Industrial Science, University of Tokyo, 2)National Institute of Advanced Industrial Science and Technology, 3)Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo
Alternatives to Animal Testing and Experimentation 11 (suppl) 257-257, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-27 Construction of the in vitro transporter experimental systems for prediction of the dexification of drugs in human liver: Utilization of human cryopreserved hepatocytes and double transfectants
Kazuya Maeda, Masaru Hirano, Naoki Ishiguro, Satoshi Kitamura, Wakaba Yamashiro, Soichiro Matsushima, Yuichi Sugiyama
Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 11 (suppl) 258-258, 2006.
Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 11 (suppl) 258-258, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-28 An evaluation for cytotoxicity and cell transformation by the measurement of glucose consumption in media
Masanori Wada1), Tomokatsu Hongo1), Shinobu Wakuri2), Yoichi Ishikawa1), Makoto Umeda2), Noriho Tanaka2)
1)Able Corporation, 2)Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 259-259, 2006.
1)Able Corporation, 2)Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 259-259, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-29 Correlation of the results between Peptide-Binding Assay using LC-mass spectrometry and LLNA
Takashi Morimoto, Yosuke Nakamura, Tamaki Higaki, Kazuko Yamashita, Masahiko Okamoto, Mika Ota, Kazuhiko Nishioka
Sumitomo Chemical Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 260-260, 2006.
Sumitomo Chemical Co. , Ltd.
Alternatives to Animal Testing and Experimentation 11 (suppl) 260-260, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-30 The influence of light source and cell line on in vitro phototoxicity tests
Noriyasu Imai1), Shinobu Otani2), Makoto Mizuno1), Yoshikazu Naoe1), Miki Nakanishi1), Yuko Okamoto1)
1)KOSE Corporation Fundamental Research Center, 2)Kyoritsu University of Pharmacy
Alternatives to Animal Testing and Experimentation 11 (suppl) 261-261, 2006.
1)KOSE Corporation Fundamental Research Center, 2)Kyoritsu University of Pharmacy
Alternatives to Animal Testing and Experimentation 11 (suppl) 261-261, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-31 Irradiation conditions and its effects in photoclastogenicity test in vitro
Kohji YAMAKAGE, Toshitaka TAKAHASHI, Shin ASADA, Noriho TANAKA
Hatano Res. Inst. , Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 262-262, 2006.
Hatano Res. Inst. , Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 262-262, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-32 Alternative test for in vivo acute systemic toxicity (3): Comparative evaluation of Collagen gel assay in two laboratories for predicting in vivo acute systemic toxicity
M. Kitagaki 1), S. Wakuri 2), N. Tanaka 2), H. Itagaki 1)
1) Shiseido Safety and Analytical Research Center, 2) Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 263-263, 2006.
1) Shiseido Safety and Analytical Research Center, 2) Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 11 (suppl) 263-263, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-33 Application of in vitro cytotoxicity test for alternative method to systemic toxicity in vivo - metabolic activation system and treatment period -
Shinobu Wakuri1), Yasuo Ohno2), Noriho Tanaka1)
1) Hatano Research Institute, Food and Drug Safety Center, 2) National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 264-264, 2006.
1) Hatano Research Institute, Food and Drug Safety Center, 2) National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 264-264, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-34 Educational Issue of 3Rs in Japan
Yukihisa Matsuda1), Tsutomu Miki Kurosawa2)
1) Akita University, Animal Research Laboratory, Bioscience Research-Education Center, 2) Osaka University, Medical School, The Institute of Experimental Animal Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 265-265, 2006.
1) Akita University, Animal Research Laboratory, Bioscience Research-Education Center, 2) Osaka University, Medical School, The Institute of Experimental Animal Sciences
Alternatives to Animal Testing and Experimentation 11 (suppl) 265-265, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-35 The current Japanese students' activities for alternatives in veterinary education
Eriko Gotoh
InterNICHE
Alternatives to Animal Testing and Experimentation 11 (suppl) 266-266, 2006.
InterNICHE
Alternatives to Animal Testing and Experimentation 11 (suppl) 266-266, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-36 The Depth of Ketamine Based Anesthesia Evaluated by Visual Evoked Potentials in Mice
Shoko Obora1), Masaru Tajima1), Tomomitsu Miyoshi2), Hajime Sawai2), Tsutomu Kurosawa1)
1)The Institute of Experimental Animal Sciences, Osaka University Medical School, 2)Department of Physiology, Osaka University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 267-267, 2006.
1)The Institute of Experimental Animal Sciences, Osaka University Medical School, 2)Department of Physiology, Osaka University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 11 (suppl) 267-267, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-37 Statistical Considerations for Allocation and the Number of Time Points in a ET50 Estimation Using Three Dimensional Human Skin Model
Takashi Sozu1), Masayuki Takanuma2), Ayako Shiraishi2), Chikuma Hamada1), Isao Yoshimura1)
1) Faculty of Engineering, Tokyo University of Science, 2) Graduate School of Engineering, Tokyo University of Science
Alternatives to Animal Testing and Experimentation 11 (suppl) 268-268, 2006.
1) Faculty of Engineering, Tokyo University of Science, 2) Graduate School of Engineering, Tokyo University of Science
Alternatives to Animal Testing and Experimentation 11 (suppl) 268-268, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-38 A Statistical Method for Estimating ET50 Using Small Size Data
Ayako Shiraishi1), Yohei Hyodo1), Takashi Sozu2), Chikuma Hamada2), Isao Yoshimura2)
1)Graduate School of Engineering, Tokyo University of Science, 2) Faculty of Engineering, Tokyo University of Science
Alternatives to Animal Testing and Experimentation 11 (suppl) 269-269, 2006.
1)Graduate School of Engineering, Tokyo University of Science, 2) Faculty of Engineering, Tokyo University of Science
Alternatives to Animal Testing and Experimentation 11 (suppl) 269-269, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-39 Consideration on the statistical analysis for agar method in the mouse lymphoma assay
Isao Yoshimura
Tokyo University of Science
Alternatives to Animal Testing and Experimentation 11 (suppl) 270-270, 2006.
Tokyo University of Science
Alternatives to Animal Testing and Experimentation 11 (suppl) 270-270, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-40 Development of the inclusive evaluation method for the percutaneous absorption III: Prediction of human dermal concentration of chemicals in various vehicles
Hirokazu Kouzuki1), Fumiyoshi Yamashita2), Hiroshi Itagaki1), Mitsuru Hashida2)
1) Shiseido Safety and Analytical Research Center, 2) Graduate School of Pharmaceutical Sciences, Kyoto University
Alternatives to Animal Testing and Experimentation 11 (suppl) 271-271, 2006.
1) Shiseido Safety and Analytical Research Center, 2) Graduate School of Pharmaceutical Sciences, Kyoto University
Alternatives to Animal Testing and Experimentation 11 (suppl) 271-271, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-41 Strategy for (Q)SAR evaluation of chemical genotoxicity
M. Hayashi1), E. Kamata2), A. Hirose2), M. Takahashi2), T. Morita3), M. Ema2)
1)Div. Genet. and Mutagen., 2)Div. Risk Assess., 3)Div. Safety Inf. on Drug, Food and Chem. , National Institute of Health Sciences, Tokyo, Japan
Alternatives to Animal Testing and Experimentation 11 (suppl) 272-272, 2006.
1)Div. Genet. and Mutagen., 2)Div. Risk Assess., 3)Div. Safety Inf. on Drug, Food and Chem. , National Institute of Health Sciences, Tokyo, Japan
Alternatives to Animal Testing and Experimentation 11 (suppl) 272-272, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-42 Establishment of in silico systems to predict the effects of genetic polymorphism on the enzymatic activity of cytochrome P450
Ayako Tokumitsu1), Kazuma Kiyotani2), Shunsuke Iwano2), Hiroshi Yamazaki2), Tetsuya Kamataki2), Yoshinori Mitamura1)
1)Graduate School of Information Science and Technology, Hokkaido University, 2)Graduate School of Pharmaceutical Sciences, Hokkaido University
Alternatives to Animal Testing and Experimentation 11 (suppl) 273-273, 2006.
1)Graduate School of Information Science and Technology, Hokkaido University, 2)Graduate School of Pharmaceutical Sciences, Hokkaido University
Alternatives to Animal Testing and Experimentation 11 (suppl) 273-273, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-43 Influence of hypothyrodism induced by thiamazole on the drug interaction in chick embryos
Yuji Yoshiyama, Michiko Shioiri, Tomomi Ikeda, Ayumi Sato, Kazumi Kanai, Motoko Kanke
Division of Clinical Pharmacy, Kyoritsu university
Alternatives to Animal Testing and Experimentation 11 (suppl) 274-274, 2006.
Division of Clinical Pharmacy, Kyoritsu university
Alternatives to Animal Testing and Experimentation 11 (suppl) 274-274, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
P-44 Search for anti-aging effects of herbs and kampo using lifespan analyses of the nematode C. elegans as a marker.
Takurou Yamaguchi1), 2), Michio Tsuda1), Makoto Arai3), Yasunori Nishio2), Naoak Ishii1), 2)
1) Dep. Mol. Life Sci. , Tokai Univ. Sch. Med., 2) NemaBio, 3) Dep. Oriental Med. and Center Complementary and Alternative Med. , Tokai Univ. Sch. Med.
Alternatives to Animal Testing and Experimentation 11 (suppl) 275-275, 2006.
1) Dep. Mol. Life Sci. , Tokai Univ. Sch. Med., 2) NemaBio, 3) Dep. Oriental Med. and Center Complementary and Alternative Med. , Tokai Univ. Sch. Med.
Alternatives to Animal Testing and Experimentation 11 (suppl) 275-275, 2006.
- 全文ダウンロード： 従量制、基本料金制の方共に121円(税込) です。
