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Alternatives to Animal Testing and Experimentation 14巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN（オンライン）
2185-4726
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開始頁
CT-1 Introduction of KoCVAM for Alternative Test Methods in Korea
Soon Young Han1, 2
1KoCVAM Director, 2Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration
Alternatives to Animal Testing and Experimentation 14 (suppl) 997-997, 2009.
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SL Advancing Laboratory Animal Welfare and Public Health Science： The Role of Innovative Refinement, Reduction, and Replacement Strategies
William S. Stokes
National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, National Institutes of Health
Alternatives to Animal Testing and Experimentation 14 (suppl) 998-998, 2009.
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CT-2 Revision of EU Council Directive 86/69/EEC on animal experimentation： an overview of its impact on animal welfare and science
Coenraad F.M. Hendriksen
Netherlands Vaccine Institute (NVI), Nilthoven, The Netherlands & Netherlands Centre Alternatives to Animal Use (NCA), Utrecht University, The Netherlands.
Alternatives to Animal Testing and Experimentation 14 (suppl) 999-999, 2009.
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CT-3 Three-Dimensional Reconstructed Human Tissue Models： Current Status of Regulatory Acceptance and Industrial Use.
Rodger Curren, Hans Raabe
Institute for In Vitro Sciences, Inc., Gaithersburg
Alternatives to Animal Testing and Experimentation 14 (suppl) 1000-1000, 2009.
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S1-1 Chemical management policy and development of short-term hazard assessment methods
Takuya Igarashi
New Energy & Industrial Technology Development Organization (NEDO)
Alternatives to Animal Testing and Experimentation 14 (suppl) 1001-1001, 2009.
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S1-2 The Bhas 42 cell transformation assay： from basic researches to a guideline
Kiyoshi Sasaki1, Dai Muramatsu1, Shoko Arai1, Nobuko Endou1, Sachiko Kuroda1, Kumiko Hayashi1, Ayako Sakai1, Shojiro Yamazaki1, Yeon-mi Lim1, Makoto Umeda1, Masanori Wada2, Noriho Tanaka1
1Div. of Alternative Research, Food and Drug Safety Center, 2ABLE
Alternatives to Animal Testing and Experimentation 14 (suppl) 1002-1002, 2009.
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S1-3 Immunotoxicity： Development of a reporter gene assay system using human cell lines
Setsuya AIBA, Rumiko SAITO, Yutaka KIMURA, Ai MEMEZAWA, Ikuko NUMATA, Toshiya TAKAHASHI
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 14 (suppl) 1003-1003, 2009.
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S1-4 Development of novel alternative tests for developmental toxicity： 1) Reporter gene assays using murine ES cells
Koichi Saito, Noriyuki Suzuki, Satoshi Ando, Nobuyuki Horie
Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1004-1004, 2009.
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S1-5 Improvement of the embryo culture method for developmental toxicity tests
Masaharu Akita1, Noriko Ishizuka2, Atsushi Yokoyama3
1Dept. of Nutrition and Dietetics, Kamakura Women's University, 2Dept. of Nutrition, Kiryu University, 3Life Science Laboratory of Kanagawa
Alternatives to Animal Testing and Experimentation 14 (suppl) 1005-1005, 2009.
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S2-1 Standardization of human ES and iPS cells for drug discovery
Miho Kusuda Furue1, 2
1JCRB Cell Bank, Laboratory of Cell Cultures, Division of Bioresources, National Institute of Biomedical Innovation, 2Laboratory of Cell Processing, Institute for Frontier Medical Sciences, Kyoto University
Alternatives to Animal Testing and Experimentation 14 (suppl) 1006-1006, 2009.
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S2-2 Establishment of Disease-specific iPS Cells and Challenges in The Standardization
Isao Asaka
Center for iPS Cell Res. Appl., Kyoto Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1007-1007, 2009.
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S2-3 Development of a novel drug toxicity testing system using human iPS cells
Hiroyuki Mizuguchi1, 2
1Lab. of Gene Transfer and Regulation, National Institute of Biomedical Innovation, 2Dept. of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1008-1008, 2009.
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S2-4 Human ES cell-derived cellular models for drug discovery and development
Kazuhiro Aiba
Stem Cell and Drug Discovery Institute
Alternatives to Animal Testing and Experimentation 14 (suppl) 1009-1009, 2009.
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S2-5 Application of ES cells to toxicology -Current status and expected utilization： heart toxicity-
Tadahiro Shinozawa
Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited
Alternatives to Animal Testing and Experimentation 14 (suppl) 1010-1010, 2009.
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S2-6 A novel embryotoxic estimation method of drugs using ES cells differentiation system
Shinji Kusakawa, Akito Tanoue
Department of Pharmacology, National Research Institute for Child Health and Development
Alternatives to Animal Testing and Experimentation 14 (suppl) 1011-1011, 2009.
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S2-7 Regenerative tissues derived from stem cells and its application to pharmacological research
Yasuhiro Ogawa, Kazuhiko Oishi
Dept. of Pharmacology, Meiji Pharmaceutical Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1012-1012, 2009.
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S2-8 Evaluating system using cells derived from ES/iPS cell -Application of Cardiomyocite to safety evaluation of a medical device and quality evaluation of crude drug-
Yasuhiro Takagi1, Sumiko Kawai1, Kaori Yabuuchi1, Tsutomu Miki Kurosawa1
1The Inst. of Experimental Animal Sci., Osaka Univ. Med. Sch.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1013-1013, 2009.
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S2-9 Alternatives to animal experimentation using ES/iPS cells -Improvement of the EST-
Koichi Imai
Dept. of Biomaterials, Osaka Dental Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1014-1014, 2009.
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S3-1 Introduction
Takashi Unno
Safety Evaluation Forum
Alternatives to Animal Testing and Experimentation 14 (suppl) 1015-1015, 2009.
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S3-2 Better safety evaluation using human and rat hepatocytes in spheroids as an in vitro model
Hisakazu Iwai
Safety Evaluation Forum (Sanwa Kagaku Kenkyusho Co.,Ltd.)
Alternatives to Animal Testing and Experimentation 14 (suppl) 1016-1016, 2009.
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S3-3 Use of in silico tool in the research and development of pharmaceuticals
Ichiro Naeshiro
Strategic Research Planning Dept., Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited
Alternatives to Animal Testing and Experimentation 14 (suppl) 1017-1017, 2009.
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S3-4 Prediction of Embryotoxicity by Embryonic Stem Cell Test
Norihito Matsumoto
Investigative toxicology research group, Discovery technology laboratory, Ono Pharmaceutical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1018-1018, 2009.
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S3-5 Contribution of ICH on 3Rs in alternatives to animal experiments
Yasuo Ohno
National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 14 (suppl) 1019-1019, 2009.
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S4-1 Policy on animal experimentation of JALAS and alternatives to animal experiments
Tadao SERIKAWA
Inst. of Lab. Animals, Grad. Sch. of Med., Kyoto Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1020-1020, 2009.
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S4-2 Contribution of experimental animal technologist to Refinement and Reduction
Yuji Sakamoto
The Japanese Association for Experimental Animal Technologists., Senju Pharmaceutical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1021-1021, 2009.
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S4-3 Activities related to the 3Rs in the Japanese Society for Laboratory Animals and the Environment
Seigo Shumiya
Japanese Society for Laboratory Animals and the Environment
Alternatives to Animal Testing and Experimentation 14 (suppl) 1022-1022, 2009.
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IS-1 Introduction of animal welfare education in colleges of veterinary medicine of Korea
Jae-Hak Park
Laboratory Animal Medicine College of Veterinary Medicine Seoul National University
Alternatives to Animal Testing and Experimentation 14 (suppl) 1023-1023, 2009.
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IS-2 The Current Status of 3Rs Research in China
Yue bingfei
National Institute for the Control of Pharmaceutical and Biological Products.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1024-1024, 2009.
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IS-3 Alternatives in China： Today and Tomorrow
Qiu Lu
Shanghai Entry-Exit Inspection and Quarantine Bureau of the P. R. China
Alternatives to Animal Testing and Experimentation 14 (suppl) 1025-1025, 2009.
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IS-4 Development status of the laboratory animal industry in Beijing area
Lin Jianwei
Beijing Administrative Office of Laboratory Animal
Alternatives to Animal Testing and Experimentation 14 (suppl) 1026-1026, 2009.
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IS-5 Bioartificial skin and biocornea as screening model
Youngsook Son1, Haeng Sun Jung2, Su Hyon Lee2, Kyung Mi Jung3, Cheol Beom Park4
1Dept. of Genetic Engineering, Kyung Hee University, 2Modern Cell & Tissue Technologies, 3R&D Center, Amorepacific Co, 4Korea Testing & Research Institute
Alternatives to Animal Testing and Experimentation 14 (suppl) 1027-1027, 2009.
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M-1 Comparative studies on the ocular irritation potential of various alkyl polyglucoside surfactants
Jae-Hak Park1, Sun-A Cho2, Ju-hee Han1, Susun An2, Key Hyun Lee3, Han Kon Kim2, Tae Ryong Lee2
1Dept. of Laboratory Animal Med., College of Veterinary Medicine, Seoul National Univ., 2Skin Research Inst. AmorePacific R&D Center, 3Cosmetics & Personal Care Research Inst. AmorePacific R&D Center
Alternatives to Animal Testing and Experimentation 14 (suppl) 1028-1028, 2009.
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M-2 Permeation of several compounds through different three-dimensional cultured human skin models
Kenji Sugibayashi, Hiroaki Todo, Ken-ichi Sugie
Faculty of Pharmaceutical Sciences, Josai Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1029-1029, 2009.
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M-4 Establishment of the alternative method of animal experiment, using green fluorescent ES and iPS cells
Tsutomu Miki Kurosawa1, Sumiko Kawai1, Yasuhiro Takagi1, Kaori Yabuuchi1, Yuko Kotani1, Ryoji Hasiba1, Kyoko Shioya2, Masaru Tajima1
1The Inst. of Experimental Animal Sci., Osaka Univ. Med. Sch., 2National Cardiovascular Center, Research Inst. Laboratory Animal Unit.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1030-1030, 2009.
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LA-1 Alternatives and Anesthesia
Tsutomu Miki Kurosawa
Laboratoy for Laboratory Animal Medicine Osaka Univ. Med. Sch.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1031-1031, 2009.
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O1-1 Availability of silkworm infection model for identification of environmental pathogens and virulence factors
Kimihito Usui1, Shinya Miyazaki1, Chikara Kaito1, Kazuhisa Sekimizu1, 2
1Laboratory of Microbiology, Grad. Sch. Pharm. Sci. Univ. of Tokyo, 2Genome Pharmaceutical institute Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1032-1032, 2009.
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O1-2 Investigation of the Test Method for Eye Irritation potential Using a Reconstructed Human Corneal Model.
Masakazu Katoh, Fumiyasu Hamajima, Takahiro Ogasawara, Kenichiro Hata
Japan Tissue Engineering Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1033-1033, 2009.
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O1-3 Genotyping Using Amp-FTA Method With Buccal Swab sample
Satoshi Nakanishi, Takashi Kuramoto, Tadao Serikawa
Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University
Alternatives to Animal Testing and Experimentation 14 (suppl) 1034-1034, 2009.
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O1-4 Embryonic stem cell-derived hepatic tissue micro-culture system
Sungho Ahn1, Miho Tamai1, Yu Toyoda1, 2, Hisashi Okuyama1, Toshihiro Akaike1, Takayuki Shindo3, Yoichi Fujiyama4, Eiichi Ozeki4, Yoh-ichi Tagawa1, 5, 6
1Tokyo Tech., Grad. School of Biosci. and Biotech., 2JSPS Research Fellow, 3Shinshu Univ., Grad. School of Medicine, 4SHIMADZU CORP., 5Tokyo Tech., FCRC., 6JST PREST
Alternatives to Animal Testing and Experimentation 14 (suppl) 1035-1035, 2009.
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O2-1 The characteristics of a Bhas 42 cell transformation assay and its predictability for the carcinogenicity of chemicals
Ayako Sakai, Kiyoshi Sasaki, Dai Muramatsu, Shoko Arai, Nobuko Endou, Sachiko Kuroda, Kumiko Hayashi, Yeon-mi Lim, Shojiro Yamazaki, Makoto Umeda, Noriho Tanaka
Laboratory of Cell Carcinogenesis, Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 14 (suppl) 1036-1036, 2009.
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O2-2 Investigation of a Minimally-Required Size for a Two-Dimensional Liver Micro-Tissue toward In Vitro Toxicity Tests
Kikuo Komori, Ippei Kameda, Tetsu Tatsuma, Yasuyuki Sakai
Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 14 (suppl) 1037-1037, 2009.
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O2-3 Inter-laboratory validation study of in vitro eye irritation test； Short time Exposure (STE) test.
H. Sakaguchi1), N. Ota2), T. Omori3), H. Kuwahara4), T. Sozu5), Y. Takagi6), Y. Takahashi1), K. Tanigawa7), M. Nakanishi7), T. Nakamura8), T. Morimoto9), S. Wakuri10), Y. Okamoto7), M. Sakaguchi2), T. Hayashi4), T. Hanji6), S. Watanabe8)
1)Kao Corporation, 2)Pola Chemical Industries, INC., 3)Kyoto University, 4)Kanebo cosmetics INC., 5)Osaka University, 6)Pias Corporation, 7)KOSE Corporation, 8)LION Corporation, 9)Sumitomo Chemical Co.,Ltd., 10)FDSC
Alternatives to Animal Testing and Experimentation 14 (suppl) 1038-1038, 2009.
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O2-4 Classification for skin sensitization potency using human Cell Line Activation Test (h-CLAT)
Yuko Nukada1, Takao Ashikaga2, Takayuki Abo1, Sakiko Sono2, Hitoshi Sakaguchi1, Hiroshi Itagaki2, Naohiro Nishiyama1
1Kao Corporation, 2Shiseido Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1039-1039, 2009.
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P-1 Cardiotoxicity evaluation of the anticancer drug using chick embryo
Hiroyuki Miyazaki, Toshimi Iizuka, Motohiro Okayasu, Toshio Kouzuki, Takeshi Homma, Takashi Ogura, Yohei Inada, Akane Kakuyama, Takenori Tamaki, Tomoko Miyazaki, Miyoshi Kido, Yuji Yoshiyama
Center for Clinical Pharmacy and Clinical Sciences, Kitasato University School of Pharmacy
Alternatives to Animal Testing and Experimentation 14 (suppl) 1040-1040, 2009.
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P-2 Development of non-aqueous peptide binding assay for in vitro skin sensitization test
Teppei Nawa, Kazuhiro Hara, Masahito Usami, Masanao Niwa
Hoyu Co.,Ltd
Alternatives to Animal Testing and Experimentation 14 (suppl) 1041-1041, 2009.
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P-3 The agreement of assay results between a 6-well method and a 96-well method in the Bhas 42 cell transformation assay
Shoko Arai, Kiyoshi Sasaki, Ayako Sakai, Dai Muramatsu, Nobuko Endou, Shojiro Yamazaki, Yeon-mi Lim, Makoto Umeda, Noriho Tanaka
Division of Alternative Research, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 14 (suppl) 1042-1042, 2009.
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P-4 A Genotoxicity test system based on p53R2 gene expression in normal human skin cells
Taisei Mizota, Katsutoshi Ohno, Toshihiro Yamada
The Food Safety Research Institute, Nissin Foods Holdings Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1043-1043, 2009.
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P-5 Validation of an in vitro screening test for predicting the tumor promoting potential of chemicals based on gene expression.
Hideki Maeshima*, Katsutoshi Ohno, Toshihiro Yamada
The Food Safety Research Institute, Nissin Foods Holdings Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1044-1044, 2009.
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P-6 The value of hepatotoxicity assessment using primary cultured human hepatocytes
Yoshifumi Takenobu
Investigative toxicology research group, Discovery technology Laboratory, Ono pharmaceutical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1045-1045, 2009.
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P-7 Review of an alternative to animal testing for safety evaluation of Quasi-drug
Kojima Hajime1, IIjima Masafumi2, Matsunaga Kayoko3, Sasa Hitoshi4, Itagaki Hiroshi4, Okamoto Yuko5, Nishiyama Naohiro6, Onodera Hiroshi7, Mita Iku7, Washida Jun8, Masuyama Koichi8, Masuda Mitsuteru1, Ohno Yasuo1
1National Institute of Health Sciences, 2Showa University, 3Fujita Health University, 4Shiseido Co.Ltd., 5KOSE Corporation, 6KAO Corporation, 7Pharmaceuticals and Medical Devices Agency, 8Ministry of Health, Labour and Welfare
Alternatives to Animal Testing and Experimentation 14 (suppl) 1046-1046, 2009.
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P-8 Validation of LabCyte EPI-MODEL24, an In Vitro Assay for Detecting Skin Irritants*
Kojima Hajime1, Ando Yoko2, Yamaguchi Yoshihiro3, Kosaka Tadashi4, Suzuki Tamie5, Yuasa Atsuko6, Watanabe Yukihiko7, Shinoda Shinsuke8, Idehara Kenji9, Yoshimura Isao10, Miyaoka Etsuyoshi10, Ishiyama Kenya10, Kato Masakazu11, Omori Takashi12
1NIHS, 2Aiken Co.,Ltd., 3KOBAYASHI Pharm. Co.,Ltd., 4Inst. of Environmental Toxicology, 5Fancl Res. Inst., 6FUJIFILM Corp., 7Maruishi Pharm. Co.,Ltd., 8Drug Safety Testing Center Co.,Ltd., 9Daicel Chemical Industries, Ltd., 10Tokyo Univ. of Science, 11J-TEC, 12Kyoto Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1047-1047, 2009.
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P-9 An On-line Community of Stakeholders Interested in Non-animal Methods of Toxicity Testing
AltTox. org
AltTox. org
Alternatives to Animal Testing and Experimentation 14 (suppl) 1048-1048, 2009.
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P-10 JaCVAM statement on new alternatives to animal testing
Hajime Kojima, Tohru Inoue, Mitsuteru Masuda, Masaharu Akita*, Yasuo Ohno
*JaCVAM Steering Committee, National Institute of Health Science (NIHS), Kamakura Women's University
Alternatives to Animal Testing and Experimentation 14 (suppl) 1049-1049, 2009.
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P-11 Investigation of sensitive cytotoxicity assay detecting drug-induced mitochondrial toxicity
Eriko Toudou
Investigative toxicology research group, Discovery technology, laboratory, Ono Pharmaceutical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1050-1050, 2009.
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P-12 Bile Canalicular Formation and Hepatobiliary Transport are Enhanced in Hepatocyte Sandwich Culture on an Oxygen-permeable Polydimethylsiloxane Membrane.
Hitoshi Matsui1, 3, Fanny Evenou1, Masaru Sekijima3, Teruo Fujii2, Shoji Takeuchi2, Yasuyuki Sakai2
1BEANS Laboratory, 2Inst. of Ind. Sci., Univ. of Tokyo, 3Mitsubishi Chemical Medience Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1051-1051, 2009.
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P-13 Evaluation of three dimensional cultured skin models using membrane permeation test
Kenji Sugibayashi1, Hiroaki Todo1
1Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 14 (suppl) 1052-1052, 2009.
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P-14 Development of a human corneal epithelium model utilizing a collagen vitrigel membrane and its application to eye irritation test
Kazunori Nishikawa1, 2, Tomoko Yamamoto1, Pi-Chao Wang2, Toshiaki Takezawa1
1Transgenic Animal Research Center, National Institute of Agrobiological Sciences, 2College of Agrobiological Resource Sciences, University of Tsukuba
Alternatives to Animal Testing and Experimentation 14 (suppl) 1053-1053, 2009.
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P-15 Reproducibility of human 3-dimensional cultured epidermal model (LabCyte EPI-MODEL)
Fumiyasu Hamajima, Masakazu Katoh, Takahiro Ogasawara, Kenichiro Hata
Japan Tissue Engineering Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1054-1054, 2009.
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P-16 The Skin Irritation Test using the Human Epidermal Model LabCyte EPI-MODEL24 ： examination with 54 materials
Takahiro Ogasawara, Masakazu Katoh, Fumiyasu Hamajima, Ken-ichiro Hata
Japan Tissue Engineering Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1055-1055, 2009.
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P-17 Statistical Issues in the Design and Analysis of Validation Studies
Takashi Sozu1, Takashi Omori2, Isao Yoshimura3
1Osaka University, 2Kyoto University, 3Tokyo University of Science
Alternatives to Animal Testing and Experimentation 14 (suppl) 1056-1056, 2009.
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P-18 The effect of chemical compound on cultured rat embryos in S-9mix
Noriko Ishizuka1, Masaharu Akita2, Atushi Yokoyama3
1Kiryu University, 2Kamakura Women's University, 3Kanagawa Life Science Research Laboratory
Alternatives to Animal Testing and Experimentation 14 (suppl) 1057-1057, 2009.
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P-19 Evaluation of eye irritation potential of 114 chemicals and correspondence to GHS classification using in vitro Short Time Exposure (STE) test.
Kazuhiko Hayashi1, Yutaka Takahashi1, Mirei Koike1, Hitoshi Sakaguchi1, Takumi Hayashi2, Hirofumi Kuwahara2, Naohiro Nishiyama1
1Kao corporation, 2Kanebo cosmetics INC.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1058-1058, 2009.
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P-20 Skin Sensitization Study by Quantitative Structure-Activity Relationships
Kazuhiro Sato1, Tomohiro Umemura1, Yukinori Kusaka1, Kohtaro Yuta2
1Department of Environmental Health, School of Medicine, University of Fukui., 2Fujitsu Limited(Present； National Institute for Environmental Studies)
Alternatives to Animal Testing and Experimentation 14 (suppl) 1059-1059, 2009.
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P-21 Direct prediction of toxicity scores using the data obtained from an alternative test： A prediction model
Takashi Omori1
1Kyoto University School of Public Health
Alternatives to Animal Testing and Experimentation 14 (suppl) 1060-1060, 2009.
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P-22 Whole embryo culture with minivaial on rat embryo of day 9.5.
A. Yokoyama1, 3, G.B. Vertrich3, H. Yokoyama3, M. Akita2
1Kanagawa Life-Sciense Research, 2Kamakura woman's college, 3Baltimore Life-sciense research
Alternatives to Animal Testing and Experimentation 14 (suppl) 1061-1061, 2009.
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P-23 Evaluation of heterotypic cellular interactions using detachable substrates under controlled flow conditions
T. Kawashima1, T. Yokoi1, H. Kaji1, 2, T. Abe1, 2, M. Nishizawa1, 2
1Tohoku University, 2JST-CREST
Alternatives to Animal Testing and Experimentation 14 (suppl) 1062-1062, 2009.
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P-24 The international validation study for the ER alpha STTA Antagonist Assay using HeLa9930
Atsushi Ono1, Masahiro Takeyoshi2, Susanne Bremer3, Miriam Jacobs4, Susan C. Laws5, Takashi Sozu6, Hajime Kojima1
1JaCVAM, NIHS, 2CERI, 3ECVAM, 4EFSA, 5US-EPA, 6MEI center, Osaka Univ.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1063-1063, 2009.
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P-25 Construction of a three-dimensional heterogeneous micro-tissue toward the evaluation of a minimum required size
H. Suzuki, H. Kimura, K. Komori, T. Fujii, Y. Sakai
Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 14 (suppl) 1064-1064, 2009.
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P-26 A combined test skin irritation evaluation： Monolayer cell, human skin model tests and human patch test
Maki Nakamura1, Yamaguchi Yoshihiro1, Li Xiaolin2, Li Jian2, Xiong Wei2, Qiu Lu2
1Kobayashi Pharmaceutical Central R&D Laboratory, 2Shanghai Entry-Exit Inspection and Quarantine Bureau of the P. R. China
Alternatives to Animal Testing and Experimentation 14 (suppl) 1065-1065, 2009.
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P-27 Evaluating system using cells derived from ES/iPS cell - Movie image analysis of beating cardiomyocyte-
Yasuhiro Takagi1, Sumiko Kawai1, Kaori Yabuuchi1, Karin Shimada1, Ayaka Iwao1, Yuko Kotani1, Ryoji Hashiba1, Kyoko Shioya2, Masaru Tajima1, Tsutomu Miki Kurosawa1
1The Inst. of Experimental Animal Sci., Osaka Univ. Med. Sch., 2National Cardiovascular Center, Research Inst. Laboratory Animal Unit
Alternatives to Animal Testing and Experimentation 14 (suppl) 1066-1066, 2009.
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P-28 Evaluating system using cells derived from ES/iPS cell - Microscopic observations of the differentiated multilayered cardiomyocytes-
Kaori Yabuuchi1, Sumiko Kawai1, Yasuhiro Takagi1, Yuko Kotani1, Ryoji Hashiba1, Kyoko Shioya2, Masaru Tajima1, Tsutomu Miki Kurosawa1
1The Inst. of Experimental Animal Sci., Osaka Univ. Med. Sch., 2National Cardiovascular Center, Research Inst. Laboratory Animal Unit
Alternatives to Animal Testing and Experimentation 14 (suppl) 1067-1067, 2009.
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P-29 Evaluating system using cells derived from ES/iPS cell - Inspection of cardiomyocyte toxicity by chemicals-
Sumiko Kawai1, Yasuhiro Takagi1, Kaori Yabuuchi1, Yuko Kotani1, Ryoji Hasiba1, Kyoko Shioya2, Masaru Tajima1, Tsutomu Miki Kurosawa1
1The Inst. of Experimental Animal Sci., Osaka Univ. Med. Sch., 2National Cardiovascular Center, Research Inst. Laboratory Animal Unit.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1068-1068, 2009.
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P-30 Evaluating system using cells derived from ES/iPS cell - Application to a screening method of crude drug constituting a Chinese medical prescription-
Yasuhiro Takagi1, Sumiko Kawai1, Kaori Yabuuchi1, Yuko Kotani1, Ryoji Hashiba1, Kyoko Shioya2, Masaru Tajima1, Tsutomu Miki Kurosawa1
1The Inst. of Experimental Animal Sci., Osaka Univ. Med. Sch., 2National Cardiovascular Center, Research Inst. Laboratory Animal Unit
Alternatives to Animal Testing and Experimentation 14 (suppl) 1069-1069, 2009.
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P-31 Analysis of marker genes for prediction of embryotoxicity in neural differentiation using mouse embryonic stem cells
Noriyuki Suzuki, Satoshi Ando, Nobuyuki Horie, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1070-1070, 2009.
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P-32 Development of in vitro alternative method for developmental toxicity using mouse embryonic stem cells
Noriyuki Suzuki, Nobuyuki Horie, Satoshi Ando, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1071-1071, 2009.
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P-33 Investigation of an Eye Irritation Test Using a Human 3D Corneal Model
Satoshi Nakahara
Central Research Laboratories, Mandom Corporation
Alternatives to Animal Testing and Experimentation 14 (suppl) 1072-1072, 2009.
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P-34 Training in anatomy using Japanese flying squid for college students majoring in nutrition and food -To increase the learning effects of clinical training in rat anatomy-
Michiko Sakamoto, Yukiko Nomura
Faculty of Food and Nutrition, Kyushu Nutrition Welfare University
Alternatives to Animal Testing and Experimentation 14 (suppl) 1073-1073, 2009.
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P-35 Expansion of Short Time Exposure(STE)Test ：Solvent Study
Mayumi Sakaguchi, Tomoko Kasahara, Shigemi Kinoshita, Akio Shibamoto, Keiji Nishizumi, Naoko Ota

Alternatives to Animal Testing and Experimentation 14 (suppl) 1074-1074, 2009.
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P-36 The influence of culture days of the reconstructed epidermis model (EPISKIN(TM)) to the result of the skin irritation test with EPISKIN(TM)
Koji Kurihara1, Shoichi Yahagi2, Yuri Okano2, Hitoshi Masaki2
1Nikoderm Research Inc., 2Cosmos Technical Center Co.,Ltd.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1075-1075, 2009.
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P-37 A Modified Short-Time Exposure (mSTE) Test for Cosmetics： an Alternative to the Draize Eye Irritation Test
Yoshihiro Yamaguchi1, Lu Qiu2, Xiaolin Li2, Junping Liu2
1Kobayashi Pharmaceutical Co.,LTD. Central R&D Lab., 2Shanghai Entry-Exit Inspection and Quarantine Bureau of the P.R. China
Alternatives to Animal Testing and Experimentation 14 (suppl) 1076-1076, 2009.
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P-38 International Validation study of the in Vitro Alkaline Comet Assay
M. Honma1, K. Yamakage2, B. Burlinson3, P. Escobar4, K. Pant5, A. Kraynak6, M. Hayashi7, M. Nakajima7, M. Suzuki7, R. Corvi8, Y. Uno9, L. Schechtman10, R. Tice11, H. Kojima1
1National Institute of Health Sciences, 2Food and Drug Safety Center, 3Huntingdon Life Science, 4Boehringer-Ingelheim, 5Bio-Reliance, 6Merck, 7Biosafety Research Center, 8ECVAM, 9Mitsubishi Tanabe Pharm, 10Innovative Toxicology Consulting, 11NIEHS/ICCVAM/NICEATM
Alternatives to Animal Testing and Experimentation 14 (suppl) 1077-1077, 2009.
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P-39 Whole embryo culture with minivial on rat embryo of day 9.5.
A. Yokoyama1, 3, G.B. Vertrich3, H. Yokoyama3, M. Akita2
1Kanagawa Life-Sciense Research, 2Kamakura woman's college, 3Baltimore Life-sciense research
Alternatives to Animal Testing and Experimentation 14 (suppl) 1078-1078, 2009.
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P-40 In vitro phototoxicity assessment of tattoo pigments using 3T3 fibroblast and reconstructed human skin model
Young Na Yum, Chae-Hyung Lim, Yong Kyoung Lee, Mi Jang, Eun Jeong Kim, Soojung Son, Soon Young Han
Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration
Alternatives to Animal Testing and Experimentation 14 (suppl) 1079-1079, 2009.
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P-41 Integration of Micronucleus Assay into General Toxicity Testing for 3Rs
Young Na Yum, Hee Yun Kim, Joo Hwan Kim, Soojung Sohn, Sue Nie Park, Seung Hee Kim, Soon Young Han
Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration
Alternatives to Animal Testing and Experimentation 14 (suppl) 1080-1080, 2009.
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P-42 Reduced numbers of fish used in acute toxicity testing
Marysia Tobor-Kaplon, D.F. de Roode, Ir. L.M. Bouwman
Institution NOTOX B. V.
Alternatives to Animal Testing and Experimentation 14 (suppl) 1081-1081, 2009.
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P-43 Real-time evaluation of hemocompatible materials by substandard human blood for transplantation by blood bank
Satoshi Seki2, Katsuko Furukawa1, Hanako Miki1, Kazuyuki Mizuhara2, Takashi Ushida1
1Department of Bioengineering, Department of Mechanical Engineering, School of Engineering, University of Tokyo, 2Department of mechanics, School of engineering, Tokyo Denki University
Alternatives to Animal Testing and Experimentation 14 (suppl) 1082-1082, 2009.
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