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Alternatives to Animal Testing and Experimentation 16巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN（オンライン）
2185-4726
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開始頁
SL-1 Pitfall in the development of cosmetics -Wheat allergy caused by hydrolysed wheat protein
Eishin Morita
Shimane University Faculty of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 151-151, 2011.
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SL-2 Molecular Basis of Environmental Responses
Masayuki Yamamoto
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 152-152, 2011.
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S1-1 The Challenge of JCIA to take advantage of in vitro /in silico methods for chemicals management
Shinji Kotachi
Japan Chemical Industry Association
Alternatives to Animal Testing and Experimentation 16 (suppl) 153-153, 2011.
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S1-2 Utilization of OECD QSAR Toolbox for prediction of chemical safety
Yuki Sakuratani
Chemical Management Center, National Institute of Technology and Evaluation
Alternatives to Animal Testing and Experimentation 16 (suppl) 154-154, 2011.
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S1-3 Establishment of JCIA in silico Working Group
Daisuke Araki
Japan Cosmetic Industry Association Alternative Testing Task Force
Alternatives to Animal Testing and Experimentation 16 (suppl) 155-155, 2011.
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S1-4 Approach of Shiseido for Safety Assessment in silico
Hirokazu Kouzuki
Research Center, Shiseido Co., Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 156-156, 2011.
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S1-5 Framework for SAR-based Toxicological Assessments
Sanae Takeuchi
P&G Innovation Godo Kaisha
Alternatives to Animal Testing and Experimentation 16 (suppl) 157-157, 2011.
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S2 The International Cooperation on Alternative Test Methods (ICATM) update
William Stokes*, Hajime Kojima**
*NIEHS, **JaCVAM, **NIHS Japan
Alternatives to Animal Testing and Experimentation 16 (suppl) 158-158, 2011.
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S3-1 Recent Progress in the Development of Organ-on-a-Chip Devices for Drug Discovery
Hirokazu Kaji
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University
Alternatives to Animal Testing and Experimentation 16 (suppl) 159-159, 2011.
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S3-2 Multi-Functional Hydrogel as Biomaterials
Takayuki Kurokawa, Jian Ping Gong
Faculty of Advanced Life Science, Hokkaido University
Alternatives to Animal Testing and Experimentation 16 (suppl) 160-160, 2011.
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S3-3 Microfluidic Assembly of 3D Tissue Models
Shoji Takeuchi
Institute of Industrial Science, Univ.of Tokyo, JST-ERATO
Alternatives to Animal Testing and Experimentation 16 (suppl) 161-161, 2011.
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S3-4 Toward Realization of Bionic Simulator
Fumihito Arai
Department of Micro-Nano Systems Engineering, Nagoya University
Alternatives to Animal Testing and Experimentation 16 (suppl) 162-162, 2011.
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S4-1 The Utility of the Peroxidase Peptide Reactivity Assay for the Identification of Skin Allergens
G.Frank Gerberick1, John A.Troutman1, Leslie M.Foertsch1, Jean-Pierre Lepoittevin2
1Central Product Safety, Miami Valley Innovation Center, The Procter & Gamble Company, 2Universite of Strasbourg, Laboratoire de Dermatochimie, Institut de Chimie
Alternatives to Animal Testing and Experimentation 16 (suppl) 163-163, 2011.
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S4-2 Chemistry and Mechanism of SH-group Modifications Involved in Skin Sensitization
Yoshiharu Iwabuchi
Graduate School of Pharmaceutical Sciences, Tohoku University
Alternatives to Animal Testing and Experimentation 16 (suppl) 164-164, 2011.
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S4-3 Development and application of in vitro sensitization assay using changes of cell-surface thiols as a biomarker (SH test)
Morihiko Hirota1, Hirokazu Kouzuki1, Takao Ashikaga1, Sakiko Sono1, Hitoshi Sasa1, Setsuya Aiba2
1Shiseido Research Center, Shiseido Co.Ltd, 2Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 165-165, 2011.
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S4-4 The human Cell Line Activation Test (h-CLAT) based on alteration of cell surface markers expression by developed and applied in Japan
H.Sakaguchi1, T.Ashikaga2, Y.Nukada1, S.Sono2, M.Miyazawa1, H.Sasa2, N.Nishiyama1
1Kao Safety Science Research Laboratories, 2Shiseido Research Center
Alternatives to Animal Testing and Experimentation 16 (suppl) 166-166, 2011.
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S4-5 IL-8 Luc assay: a novel in vitro Test to Screen Skin Sensitizers Using a Stable THP-1-derived IL-8 Reporter Cell Line, THP-G8
Setsuya Aiba
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 167-167, 2011.
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S5-1 Current update for the Ministry of Health, Labour and Welfare on the development of alternative chemical safety tests
Hajime Kojima
Japanese Center for the Validation of Alternative Methods (JaCVAM), National Institute of Health Sciences (NIHS)
Alternatives to Animal Testing and Experimentation 16 (suppl) 168-168, 2011.
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S5-4 A new MAFF project "Agri-health translational research project (Vitrigel)"
Toshiaki Takezawa
National Institute of Agrobiological Sciences
Alternatives to Animal Testing and Experimentation 16 (suppl) 169-169, 2011.
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S6-1 Nano/Micro particles and cell bioreacton
Fumio Watari
Graduate School of Dental Medicine, Hokkaido University
Alternatives to Animal Testing and Experimentation 16 (suppl) 170-170, 2011.
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S6-2 Three Dimensional Tissue Regeneration Using RWV Bioreactor and Its In Vitro Evaluation
Toshimasa UEMURA
Nanosystem Research Institute (NRI), National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 16 (suppl) 171-171, 2011.
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S6-3 Paramecium as a sensitive in vitro bioassay system for cytotoxicity of nanomaterials
Nobuyuki Haga1, Taiki Abe1, Koichi Haneda2
1Department of Biological Engineering, Senshu University of Ishinomaki, 2Department of Information and Electronics, Senshu University of Ishinomaki
Alternatives to Animal Testing and Experimentation 16 (suppl) 172-172, 2011.
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S6-4 Evaluation on cell damage by titanium fine particles, copper ions and TEGDMA monomer using THP-1 cells
Masayuki Taira
Department of Biomedical Engineering, Iwate Medical University
Alternatives to Animal Testing and Experimentation 16 (suppl) 173-173, 2011.
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S6-5 Cell culture on carbon nanotube thin films
Tsukasa Akasaka, Fumio Watari
Graduate School of Dental Medicine, Hokkaido University
Alternatives to Animal Testing and Experimentation 16 (suppl) 174-174, 2011.
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S6-6 In Vitro Embryotoxicity Test of Nanomaterials with ES cells
Koichi Imai
Department of Biomaterials, Osaka Dental University
Alternatives to Animal Testing and Experimentation 16 (suppl) 175-175, 2011.
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IS-2 The Evolution of Skin Sensitization Test Methods and their Utility in Quantitative Risk Assessment
G.Frank Gerberick, Cindy A.Ryan, Carsten Goebel, Petra S.Kern
The Procter and Gamble Company
Alternatives to Animal Testing and Experimentation 16 (suppl) 176-176, 2011.
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IS-3 Recent Research of Alternative Methods in Biotoxtech, Korea
Mi-Sook Jung1, Mi-Ae Park1, Heung-Mo Bae1, Tae-Won Jeon1, Seong-Jin Baek1, Jong-Koo Kang1, 2
1Biotoxtech Co., Ltd, 2Chungbuk National University
Alternatives to Animal Testing and Experimentation 16 (suppl) 177-177, 2011.
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IS-4 Brief introduction on the alternative animal experiment for the evaluation of efficacy and safety in veterinary therapeutics - Evaluation of hepatotoxicity and neurotoxicity for chemicals using the cells differentiated from mouse embryonic stem cell-
Hwan-Goo Kang, Sang-Hee Jeong, Eun-Ju Park, Young-Il Park, Seong-Wan Son
Animal, Plant and Fisheries Quarantine and Inspection Agency
Alternatives to Animal Testing and Experimentation 16 (suppl) 178-179, 2011.
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EL-1 The Late Emeritus Professor Tsutomu Sugahara and the JSAAE
Atsushige Sato
Tokyo Medical and Dental University
Alternatives to Animal Testing and Experimentation 16 (suppl) 180-180, 2011.
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EL-2-1 The Principle of humane Experimental Technique. What did Russell & Burch mention in the book ?
Noriyuki Kasai
Institute for Animal experimentation Tohoku University School of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 181-181, 2011.
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EL-2-2 -Thoughts in animal life and responsibility of technician- With an experience of Eastern Japan Earthquake
Teruko SUETA
Institute for Animal Experimentation Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 182-182, 2011.
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EL-3 Education program on animal-experiment ethics based on international guidelines
Shigeo Ito
Laboratory of Pharmacology, Graduate School of Veterinary Medicine, Hokkaido University
Alternatives to Animal Testing and Experimentation 16 (suppl) 183-183, 2011.
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M-1 Fabrication of biomimetic tissues composed of cells of more than 2 types: A promising new prospect for biomedical studies
Jeong Ik Lee1, 2, Hyun Woo Kim1, 2, Su Jin Bae2, 3
1Department of Biomedical Science and Technology, Regenerative Medicine Laboratory, 2Center for Stem Cell Research, SMART Institute of Advanced Biomedical Science, 3Department of Molecular Biotechnology, Konkuk University
Alternatives to Animal Testing and Experimentation 16 (suppl) 184-184, 2011.
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M-2 Acetylcholine inhibits the hypoxia and hydrogen peroxide -induced reduction of connexin43 protein in rat cardiomyocytes.
Hideto Ariumi
Division of Community Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmacy, Kitasato University
Alternatives to Animal Testing and Experimentation 16 (suppl) 185-185, 2011.
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M-3 A study of the eye irritation test using new immortalized human corneal epithelium.
Naoki Yamamoto
Laboratory of molecular biology and histochemistry, Joint research laboratory, Fujita Health University
Alternatives to Animal Testing and Experimentation 16 (suppl) 186-186, 2011.
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M-4 Quantitative prediction method of in vivo renal clearance of drugs using human kidney and expression system
Hiroyuki Kusuhara
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 16 (suppl) 187-187, 2011.
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M-5 A New Alternative Method to Draize Test Using Dynamics of Giant Liposome
Masahiro TAKAGI
School of Materials Science, Japan Advanced Institute of Science and Technology
Alternatives to Animal Testing and Experimentation 16 (suppl) 188-188, 2011.
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P-1 Evaluation of Newly-Developed Qualitative Structure-Activity Relationships software
Masahiro Haitsuka1, Kunihiko Yamashita1, Masatake Kudoh1, Kohtaro Yuta2, Kazuhiro Sato3, Yukinori Kusaka3
1Daicel Chemical Industries, Ltd, 2In Silico Data, Ltd, 3University of Fukui
Alternatives to Animal Testing and Experimentation 16 (suppl) 189-189, 2011.
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P-2 Skin sensitization study by a new qualitative structure-toxicity relationships (QSTR) approach: K-step Yard sampling (KY) methods
Kazuhiro Sato1, Kohtaro Yuta2, Yukinori Kusaka1
1Department of Environmental Health, School of Medicine, University of Fukui, 2In Silico Data Co Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 190-190, 2011.
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P-3 Testing strategy for skin sensitization by using in vitro tests and in silico system
Yuko Nukada, Hiroki Sano, Masaaki Miyazawa, Kazutoshi Saito, Hitoshi Sakaguchi, Naohiro Nishiyama
Kao Corporation
Alternatives to Animal Testing and Experimentation 16 (suppl) 191-191, 2011.
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P-4 The optimization for preparing the lymph node cell suspension in LLNA BrdU-ELISA
Yuko Maruyama1, Atsuko Yuasa1, Takanori Hioki1, Toshihiko Kasahara1, Hajime Kojima2
1Safety Evaluation Center, Environment & Quality Management Div., CSR Div., FUJIFILM Corporation, 2National Center for Biological Safety and Research, NIHS
Alternatives to Animal Testing and Experimentation 16 (suppl) 192-192, 2011.
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P-5 Standardization for measurement about ear thickness of the pre-screen test on TG442A (LLNA:DA)
Kunihiko Yamashita1, Takashi Omori2, Shinsuke Shinoda3, Saori Hagiwara
1Daicel Chemical Industries, Ltd, 2Doshisha University, 3Drug Safety Testing Center Co., Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 193-193, 2011.
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P-6 Development of a new in vitro skin sensitization assay using Reconstructed Human Epidermis (EpiSensA)
Saito, Kazutoshi, Nukada, Yuko, Takenouchi, Osamu, Miyazawa, Masaaki, Sakaguchi, Hitoshi, Nishiyama, Naohiro
Kao Corporation
Alternatives to Animal Testing and Experimentation 16 (suppl) 194-194, 2011.
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P-7 An alternative method using a novel Cys derivative with UV absorption for skin sensitization test
Masaharu Fujita1, Yuko Maruyama1, Atsuko Yuasa1, Yoshiyuki Jinbo2, Takanori Hioki1
1Safety Evaluation Center, Environment & Quality Management Div., CSR Div., FUJIFILM Corporation, 2Synthetic Organic Chemistry Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation
Alternatives to Animal Testing and Experimentation 16 (suppl) 195-195, 2011.
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P-8 An attempt to improve the accuracy of IL-8 Luc assay
Yutaka Kimura1, Toshiya Takahashi1, Rumiko Saito1, Yoshihiro Nakajima2, Yoshihiro Ohmiya2, Kenshi Yamasaki1, Setsuya Aiba1
1Department of Dermatology, Tohoku University Graduate School of Medicine, 2Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 16 (suppl) 196-196, 2011.
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P-9 Integrated Testing Strategies (ITS) for risk assessment of skin sensitization test in vitro
Kyoko Tsujita1, Morihiko Hirota1, Takao Ashikaga1, Sakiko Sono1, Hirokazu Kouzuki1, Setsuya Aiba2
1Shiseido Research Center, Shiseido Co. Ltd, 2Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 197-197, 2011.
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P-10 Basic study of an alternative test method of skin sensitization model using vitrigel chamber
Tadashi Uchino1, Toshiaki Takezawa2, Kunihiko Yamashita3, Hajime Kojima1, Yoshiaki Ikarashi1, Testuji Nishimura1
1National Institute of Health Sciences, 2National Institute of Agrobiological Sciences, 3Daicel Chemical Industries, Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 198-198, 2011.
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P-11 Statistical prediction model for skin sensitization potential using an integrated dataset from h-CLAT, DPRA, and DEREK.
Kenji Okamoto1, Yuko Nukada2, Masaaki Miyazawa2, Hitoshi Sakaguch2, Akihiko Takatsu1
1Kanebo Cosmetics Inc, 2Kao Corporation
Alternatives to Animal Testing and Experimentation 16 (suppl) 199-199, 2011.
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P-12 Development of the in vitro photo-sensitization assay by detecting changes of cell surface thiols and amines
Shiho Oeda1, Morihiko Hirota1, Hirokazu Kouzuki1, Setsuya Aiba2, Yoshiki Tokura3
1Shiseido Research Center, 2Department of Dermatology, Tohoku University Graduate School of Medicine, 3Department of Dermatology, Hamamatsu University School of Medicine
Alternatives to Animal Testing and Experimentation 16 (suppl) 200-200, 2011.
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P-13 Additonal multisite study of reconstructed human epidermis, LabCyte EPI-MODEL24 skin irritation test.
Shinoda, S.1, Hagiwara, S.1, Yamagichi, Y.2, Nakamura, A.2, Kasahara T.3, Shibai A.3, Katoh, M.4, Kojima, H.5
1Drug Safety Testing Center Co., Ltd, 2KOBAYASHI Pharmaceutical Co., Ltd, 3FUJIFILM Corporation, 4Japan Tissue Engineering Co., Ltd, 5National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 16 (suppl) 201-201, 2011.
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P-14 Study of in vitro skin irritation test targeted for sensitive skin
Hidefumi Ikeda1, Hideki Nishiura1, Masakazu Katoh2
1Nihon Kolmar Co., Ltd, 2Japan Tissue Engineering Co., Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 202-202, 2011.
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P-15 Chemical list for the development of alternatives for skin irritation
Yasuo Ohno, Masaharu Akita, Noriyasu Imai, Takashi Omori, Yuko Okamoto, Hidenobu Okumura, Yuki Kawano, Mariko Sugiyama, Shigenobu Hagino
JSAAE working group for the alternatives offor the skin irritation test working group
Alternatives to Animal Testing and Experimentation 16 (suppl) 203-203, 2011.
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P-16 The Reproducibility of the Validated EPI-200 Skin Irritation Test (EPI-200 SIT) in Japan
Yuki Handa1, Fumi Ichinose1, Helena Kandarova2, Hiroshi Yanase1
1Kurabo Industries Ltd, 2MatTek Corporation
Alternatives to Animal Testing and Experimentation 16 (suppl) 204-204, 2011.
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P-17 Novel efficacy evaluations of cosmetics with reconstructed human epidermis models
Daisuke Yoshida1, Yukiko Izutsu1, Keisuke Tanaka1, Nobuyuki Ujiie1, Daiki Kyotani1, 2, Jinhua Li1
1Nikkol group Cosmos Technical Center Co., Ltd, 2Nikkol group Nikoderm Research Inc
Alternatives to Animal Testing and Experimentation 16 (suppl) 205-205, 2011.
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P-18 Establishment of new in vitro eye irritation test method using the reconstructed human corneal epithelium, LabCyte CORNEA-MODEL
Masakazu Katoh, Fumiyasu Hamajima, Takahiro Ogasawara, Ken-ichiro Hata
Japan Tissue Engineering Co., Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 206-206, 2011.
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P-19 Advantage of a human corneal epithelium model reconstructed in a collagen vitrigel membrane chamber: A novel approach to extrapolate eye irritation from the time dependent profile of transepithelial electrical resistance after exposing chemicals
Hiroyuki Yamaguchi1, 3, Hajime Kojima2, Toshiaki Takezawa1
1National Institute of Agrobiological Sciences, 2National Institute of Health Sciences, 3Kanto Chemical Co.Inc
Alternatives to Animal Testing and Experimentation 16 (suppl) 207-207, 2011.
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P-20 Definition of the applicability domain of the STE test based on the background review analysis
Kazuhiko Hayashi, Yuko Nukada, Takayuki Abo, Hitoshi Sakaguchi, Naohiro Nishiyama
Kao Corporation
Alternatives to Animal Testing and Experimentation 16 (suppl) 208-208, 2011.
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P-21 A tiered approach combining three in vitro assays for predicting eye irritation potential of chemicals
Takayuki Abo1, Kenichi Ooshima2, Yuko Nukada1, Kazuhiko Hayashi1, Tomoko Komano2, Takumi Hayashi2, Daisuke Araki2, Hitoshi Sakaguchi1, Naohiro Nishiyama1
1Kao Corporation, 2Kanebo cosmetics INC
Alternatives to Animal Testing and Experimentation 16 (suppl) 209-209, 2011.
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P-22 Study on alternative eye irritation test with novel immortalized human corneal epithelial cell line
Yoshinao Kato1, Naoki Yamamoto2, Hiromi Yamashita2, Atsushi Sato1, Hiroshi Mizutani1, Satoru Nakata1, Hajime Kojima3
1Nippon Menard Cosmetic Co., Ltd, 2Fujita Health University Joint Research Laboratory, 3National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 16 (suppl) 210-210, 2011.
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P-23 Establishment and application of predictive method for skin concentration of several compounds using skin permeation parameters
Takeshi Oshizaka, Hiroaki Todo, Kenji Sugibayashi
Faculty of pharmaceutical sciences, Josai University
Alternatives to Animal Testing and Experimentation 16 (suppl) 211-211, 2011.
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P-24 Toward an establishment of high-throughput skin permeation test considering "Reduction" in 3Rs
Hiroaki Todo, Takeshi Oshisaka, Sayuri Hasegawa, Kenji Sugibayashi
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 16 (suppl) 212-212, 2011.
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P-25 Establishment of a simple screening method for skin permeation enhancers using liposomes
Yuki Kitao, Sayaka Nishio, Hiroaki Todo, Kenji Sugibayashi
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 16 (suppl) 213-213, 2011.
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P-26 Usefulness of liposome membrane as a tool to evaluate the enhancing effect of electroporation on the skin permeation of drugs
Sayaka Nishio, Hiroaki Todo, Kenji Sugibayashi
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 16 (suppl) 214-214, 2011.
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P-27 Fibrin-supported bioassay system for contractile skeletal muscle cells
Kuniaki Nagamine1, 2, Shingo Otani1, Mai Takeda1, Makoto Kanzaki1, 2, Matsuhiko Nishizawa1, 2
1Tohoku University, 2JST-CREST
Alternatives to Animal Testing and Experimentation 16 (suppl) 215-215, 2011.
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P-28 Controlling the contractile myotubes by the flexible organic electrode
Y.Ido1, D.Takahashi1, R.Suziki1, M.Sasaki1, K.Nagamine1, 2, T.Miyake1, 2, M.Nishizawa1, 2
1Tohoku University, 2JST-CREST
Alternatives to Animal Testing and Experimentation 16 (suppl) 216-216, 2011.
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P-29 Development of microwell chips for hepatocyte spheroid culture
H.Koga1, Y.Yoshiura1, T.Fujigaya2, N.Nakashima2, K.Nakazawa1
1Dept.of Life and Environment Eng., The University of Kitakyushu, 2Dept.of Applied Chem., Kyushu University
Alternatives to Animal Testing and Experimentation 16 (suppl) 217-217, 2011.
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P-30 Functional evaluation of the hepatocyte micropatterned chip
Kohji Nakazawa, Yukiko Yoshiura, Yusuke Sakai
Department of Life and Environment Engineering, The University of Kitakyushu
Alternatives to Animal Testing and Experimentation 16 (suppl) 218-218, 2011.
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P-31 Reconstruction of a three-dimensional culture model of human hepatic cancer cells utilizing a collagen vitrigel membrane chamber and its characteristics
Ayumi Oshikata, Toshiaki Takezawa
National Institute of Agrobiological Sciences
Alternatives to Animal Testing and Experimentation 16 (suppl) 219-219, 2011.
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P-33 Development of a cell assay system that combines the human artificial chromosome vector with a multicolored luminescent system
Tetsuya Ohbayashi1, Yuki Yoshimura2, Tadashi Nishida2, Yoshihiro Nakajima3, Yasuhiro Kazuki2, Yoshihiro Ohmiya4, Mitsuo Oshimura2
1Div.of Laboratory Animal Sci., Res.Ctr.for Biosci.and Technology, Tottori Univ, 2Dept.of Biomed.Sci., Inst.of Regenerative Med., Tottori Univ, 3Health Research Institute, Advanced Industrial Science And technology, 4Bioproduction Research Institute., Advanced Industrial Science And Technology
Alternatives to Animal Testing and Experimentation 16 (suppl) 220-220, 2011.
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P-34 Generation of in vitro/in vivo dual bioimaging system using human artificial chromosomes
Yuki Yoshimura1, Kazuomi Nakamura2, Yoshihiro Nakajima3, Yasuhiro Kazuki1, Yoshihiro Ohmiya4, Mitsuo Oshimura1, Tetsuya Ohbayashi2
1Dept.of Biomed.Sci., Inst.of Regenerative Med., Tottori Univ, 2Div.of Laboratory Animal Sci., Res.Ctr.for Biosci.and Technology, Tottori Univ, 3Health Research Institute., Advanced Industrial Science And technology, 4Bioproduction Research Institute., Advanced Industrial Science And Technology
Alternatives to Animal Testing and Experimentation 16 (suppl) 221-221, 2011.
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P-34 Development of a high-sensitive toxic assessment system in vitro using human artificial chromosome vector
Tadashi Nishida1, Yuki Yoshimura2, Katsutaka Sasaki2, Yoshihiro Nakajima3, Rumiko Saito4, Yasuhiro Kazuki2, Shigeaki Nishii5, Yoshihiro Ohmiya3, Setsuya Aiba4, Mitsuo Oshimura2, Tetsuya Ohbayashi6
1Chromosome Engineering Res.Cen., Tottori Univ, 2Dep.Biomedical Sci., Inst.Regenerative Medicine and Biofunction, Tottori Univ, 3AIST, 4Dep.Dermatol., Tohoku Univ, 5Tsuruga Inst.Biotechnol., Toyobo Co., Ltd, 6Div.Lab.Animal Sci., Res.Cen.Biosci.and Technol., Tottori Univ
Alternatives to Animal Testing and Experimentation 16 (suppl) 222-222, 2011.
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P-35 Development of in vitro and in silico alternative method for acute systemic toxicity in vivo.
Tomomi Atobe, Shigenobu Hagino, Masato Kitagaki, Hirokazu Kouzuki
Shiseido Reserch Center
Alternatives to Animal Testing and Experimentation 16 (suppl) 223-223, 2011.
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P-36 The sutady of monitoring system of oxygen level on cultured rat embryos.
Yokoyama, A
Kanagawa Life-science Research
Alternatives to Animal Testing and Experimentation 16 (suppl) 224-224, 2011.
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P-38 Effects of the conpound serum (CS) on cultured rat embryos.
Yokoyama, A.1, Akita, M.2
1Kanagawa Life-science Research, 2Kamakura Women's University
Alternatives to Animal Testing and Experimentation 16 (suppl) 225-225, 2011.
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P-38 An inter-laboratory pre-validation study of the novel embryonic stem cell tests (Hand1-EST and Cmya1-EST) for developmental toxicity
Noriyuki Suzuki1, Naoteru Koseki2, Yutaka Kimura3, Setsuya Aiba3, Tomoyasu Toyoizumi4, Mika Watanabe4, Ryo Ohta4, Koichi Saito1
1Institution Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd, 2Safety Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd, 3Tohoku University Graduate School of Medicine, 4Hatano Research Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 16 (suppl) 226-226, 2011.
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P-39 A validation study on the 96-well method of Bhas 42 cell transformation assay
Ayako Sakai1, Shoko Arai1, Kiyoshi Sasaki1, Dai Muramatsu1, Nobuko Endou1, Fukutaro Mizuhashi2, Sawako Kasamoto2, Miho Nagai2, Maiko Takai2, Masumi Asakura3, Nobuhiko Tashiro4, Nana Ishii4, Shojiro Yamazaki1, Makoto Umeda1, Noriho Tanaka1
1Food and Drug Safety Center, 2Biosafety Research Center, Foods, Drugs and Pesticides, 3Japan Bioassay Research Center, 4Mitsubishi Chemical Medience Corporation
Alternatives to Animal Testing and Experimentation 16 (suppl) 227-227, 2011.
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P-40 Development of myocardial toxicity test using cardiomyocytes derived from ES/iPS cells as an alternative to the cardiotoxic in vivo test -Analysis of chronotropic and inotropic actions-
Sumiko Kawai1, Yasuhiro Takagi1, Kyoko Shioya2, Tsutomu Kurosawa1
1Department of Laboratory Animal Medicine, Osaka Univ.Med.Sch, 2Laboratory of Animal experiment and medicine Management, National Cerebral and Cardiovascular Center
Alternatives to Animal Testing and Experimentation 16 (suppl) 228-228, 2011.
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P-41 Quantification of Bhas 42 cell transformation assay with hydrogen peroxide method
Kiyoshi Sasaki, Dai Muramatsu, Shoko Arai, Nobuko Endou, Ayako Sakai, Shojiro Yamazaki, Makoto Umeda, Noriho Tanaka
Laboratory of Cell Carcinogenesis, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 16 (suppl) 229-229, 2011.
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P-42 A genotoxicity test based on p53R2 gene expression in human cells. (NESMAGET, Part10) : Investigation the applicability of the test in TK6 cells
Taisei Mizota, Katsutoshi Ohno, Mina Ito, Toshihiro Yamada
Food Safety Research Institute, Nissin Foods Holdings Co., Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 230-230, 2011.
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P-43 Evaluation of in vitro micronucleus assay using three-dimensional reconstructed human skin models -Part 2-
Toshio Kasamatsu, Katsuyuki Yuki, Shoji Matsumura, Naohiro Ikeda, Naohiro Nishiyama
Kao Corporation, Global R&D-Safety Science
Alternatives to Animal Testing and Experimentation 16 (suppl) 231-231, 2011.
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P-44 Development of a well-of-the-well system-based embryo culture plate for the evaluation of embryo quality by photoluminescence imaging
K.Komori, S.Fujii, K.Montagne, H.Nakamura, H.Kimura, T.Fujii, Y.Sakai
Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 16 (suppl) 232-232, 2011.
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P-45 Analysis of metal immunotoxicity using T cell-derived Jurkat reporter cell line, #2H4
Rumiko Saito1, 2, Satoshi Hirakawa2, 3, Hiroshi Ohara4, Makoto Yasuda5, Tomomi Yamazaki5, Shigeaki Nishii5, Setsuya Aiba2
1Division of Molecular Biology, School of Life Science, Tottori University Faculty of Medicine, 2Department of Dermatology, Tohoku University Graduate School of Medicine, 3Dermatological R&D Skin Research Department, POLA Chemical Industries, Inc, 4Department of Clinical Pharmacy, Tohoku University Graduate School of Pharmaceutical Sciences, 5Tsuruga Institute of Biotechnology, TOYOBO Co., Ltd
Alternatives to Animal Testing and Experimentation 16 (suppl) 233-233, 2011.
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P-46 Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes
Hideto Ariumi, Takahito Sonobe, Ikuya Imai, Yuji Yoshiyama
Division of Community Pharmacy, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmacy, Kitasato University
Alternatives to Animal Testing and Experimentation 16 (suppl) 234-234, 2011.
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P-47 Study for the factors that influence the evaluation of subjective peel force of adhesive tapes
Maki Shibuya1, Kazuya Fukuhara1, Masaki Uchida1, Hideshi Natsume1, 2, Yasunori Morimoto1, 2
1Faculty of Pharmaceutical Sciences, Josai University, 2Research Institute of TTS Technology
Alternatives to Animal Testing and Experimentation 16 (suppl) 235-235, 2011.
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P-48 Influence prediction of phthalate by the cultured human alveolar epithelial A549 cells and the numerical model
Kokoro Iwasawa1, Genya Tanaka1, Kikuo Komori1, Takao Fujii1, Kosaku Okuyama1, Kenichi Hatanaka1, Yoshiaki Sakoda1, Toshiko Tanaka-Kagawa2, Hideto Jinno2, Yasuyuki Sakai1
1Institute of Industrial Science, The University of Tokyo, 2National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 16 (suppl) 236-236, 2011.
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P-49 Study on replacement of animal testing required in the former "Standards to Approval of Hemodializer"
Yuji Fujita, Shinichi Kora
Terumo Corporation Fujinomiya Factory
Alternatives to Animal Testing and Experimentation 16 (suppl) 237-237, 2011.
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P-50 The Japanese Center for the Validation of Alternative Methods (JaCVAM) update
Hajime Kojima
Japanese Center for the Validation of Alternative Methods (JaCVAM), National Institute of Health Sciences (NIHS)
Alternatives to Animal Testing and Experimentation 16 (suppl) 238-238, 2011.
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