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Alternatives to Animal Testing and Experimentation 19巻 suppl号

発行元
日本動物実験代替法学会
ISSN
1344-0411
ISSN(オンライン)
2185-4726

書籍情報から探す
開始頁
PL Towards social recognition of the Alternatives to Animal Experiments
Hiroshi Itagaki
Faculty of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 19 (suppl) 100-100, 2014.
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SL-2 Proposals for alternative test researchers from a dermatologist
MATSUNAGA KAYOKO
Department of Dermatology, Fujita Health University School of Medicine
Alternatives to Animal Testing and Experimentation 19 (suppl) 102-102, 2014.
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SL-3 Prediction of drug disposition in the body : Use of modeling and simulation in "Alternative to animal experiments research"
SUGIYAMA YUICHI
Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Alternatives to Animal Testing and Experimentation 19 (suppl) 104-104, 2014.
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EL Risk assessment and hazard assessment
AKIHIKO HIROSE
Division of Risk Assessment, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 106-106, 2014.
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S1-1 Application of alternative to animal testing for apptoval of Quasi-drugs - Introduction of review meeting for alternative testing -
KOJIMA HAJIME
National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 108-108, 2014.
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S1-2 The point of the guidance for in vitro 3T3 NRU phototoxicity test
NORIYASU IMAI1,2, MARIKO SUGIYAMA3, YUKO OKAMOTO
1Japan Cosmetic Industry Association (JCIA), 2KOSE Corporation, 3Shiseido Research Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 109-109, 2014.
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S1-3 The point of the guidance for three kinds of Local Lymph Node Assays
Morihiko Hirota1,2, Akemi Toyoda1,3, Jun Sato1,4, Yutaka Yamamoto1,5, Masaaki Miyazawa1,6
1Japan Cosmetic Industry Association (JCIA), 2Shiseido Research Center, 3POLA CHEMICAL INDUSTRIES, INC, 4LION CORPORATION, 5Noevir Co.,Ltd., 6Kao Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 110-110, 2014.
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S1-4 The point of the guidance for Bovine Corneal Opacity and Permeability Test
Hirokazu Seto1,2, Yuichiro Goto1,3, Sanae Takeuchi1,2, Shigenobu Hagino1,4, Aya Watanabe1,5
1Japan Cosmetic Industry Association, 2P & G, 3KOSE, 4Shiseido, 5Kanebo
Alternatives to Animal Testing and Experimentation 19 (suppl) 111-111, 2014.
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S1-5 The Guidance of Alternative Methods for Safety Assessment of Quasi-drug Products
HIROSHI ONODERA
Phaemaceuticals and Medical Devices Agency
Alternatives to Animal Testing and Experimentation 19 (suppl) 112-112, 2014.
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S1-6 Recent Trends in Development for the Alternatives to Animal Testing in Korea
Young-Jin Chun
College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea
Alternatives to Animal Testing and Experimentation 19 (suppl) 113-113, 2014.
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S2-1 Drosophila as a disease model : For the elucidation of the sick building syndrome
KAEKO KAMEI1, Masamitsu Yamaguchi2, Yoshihiro Inoue3
1Dept. of Biomolecular Engineering, Kyoto Institute of Technology, 2Dept. of Applied Biology, Kyoto Institute of Technology, 3Insect Biomedical Research Center, Kyoto Institute of Technology
Alternatives to Animal Testing and Experimentation 19 (suppl) 115-115, 2014.
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S2-2 Development of novel method to evaluate chemical compounds as the possible inducer of cancer stem cells using mouse iPS cells
MASAHARU SENO
Graduate School of Natural Science and Technology, Department of Biotechnology, Okayama University
Alternatives to Animal Testing and Experimentation 19 (suppl) 116-116, 2014.
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S2-3 Sophisticated hazard prediction by active QSAR modeling
YOSHIMASA TAKAHASHI, TOMOYA YAMAZAKI, MIKA OOYAMA, YUJI IKEGAMI
Department of Computer Science and Engineering, Toyohashi University of Technology
Alternatives to Animal Testing and Experimentation 19 (suppl) 117-117, 2014.
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S2-4 Applied research of a novel in vitro method for developmental toxicity to facilitate the industrial utilization - Overview of development and validation study of Hand1-Luc Embryonic Stem Cell Test (Hand1-Luc EST) -
YAMAKAGE KOHJI1, Noriyuki Suzuki2, Koichi Saito2, Mika Waranabe1, Naohiro Ikeda3, Kazunori Yanagi4, Takashi Omori5, Hajime Kojima6, Noriho Tanaka1
1Hatano Research Institute, Food and Drug Safety Center, 2Environmental Health Science Laboratory, Sumitomo Chemical Co.Ltd., 3Safety Science Research Laboratories, Kao Corp., 4Pharmaceutical Business Division, Sumika Chemical Analysis Service, 5Faculty of Culture and Information Science, Doshisha University, 6National Institute of Health Science (JaCVAM)
Alternatives to Animal Testing and Experimentation 19 (suppl) 118-118, 2014.
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S3-1 In vitro tests for photosafety assessment : present situation and correspondence for the problem solution
YUMIKO IWASE
Safety Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 120-120, 2014.
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S3-2 Skin sensitization assessment of various cosmetic ingredients towards ultimate replacement of animal testing
MASAAKI MIYAZAWA
Kao Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 121-121, 2014.
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S3-3 Possibility of effect and safety evaluations of chemical compounds with skin permeation experiment using alternative membranes
HIROAKI TODO
Faculty pf Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 19 (suppl) 122-122, 2014.
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S3-4 Development of human epidermis skin equivalent prototype for in vitro skin corrosion and irritation testing
Cheng-Yi Wu1, Huey-Min Lai2, Meng-Hsueh Lin2, Hui-Chun Hsu2, Tsung-Han Lee2, Chih-Ching Liao2, Wann-Hsin Chen2, Hui-Ting Huang2, Yen-Chun Chen2, Junichi Hayakawa3
1Quality Research Department, POLA Chemical Industries, INC, 2Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, 3Saticine Medical Co.,Ltd.
Alternatives to Animal Testing and Experimentation 19 (suppl) 123-123, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
S3-5 The issue and future for Alternative Primary Skin Irritation Test
MARIKO SUGIYAMA
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 124-124, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
S3-6 Animal Alternative Test Researches in SCDC
Ping Xiao
Quality Research Department, POLA Chemical Industries, INC
Alternatives to Animal Testing and Experimentation 19 (suppl) 125-125, 2014.
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S4-1 3Rs have been materialized by a certain gene modified mouse model developed under strategic plan
HIDEKI TSUTSUMI
Central Institute for Experimental Animals
Alternatives to Animal Testing and Experimentation 19 (suppl) 127-127, 2014.
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S4-2 NIR non-invasive fluorescence Imaging
YOSHIHIRO MIWA1,2, JUNKO TANAKA1, SHOTA SAKAGUCHI3, TAKANOBU KUROYAMA3, TOMOKI SAKASAI3, KOSUKE KAWAMURA3
1Faculty of Medicine, University of Tsukuba, 2Laboratory Animal Resource Center, University of Tsukuba, 3Graduate School of Comprehensive Human Science, University of Tsukuba
Alternatives to Animal Testing and Experimentation 19 (suppl) 128-128, 2014.
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S4-3 Application possibility of micro-computed tomography imaging to the 3Rs : Reduction, Replacement and Refinement of animal experiments
MASARU TAMURA
Technology and Development Team for Mouse Phenotype Analysis, RIKEN Bio-Resource Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 129-129, 2014.
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S4-4 Activities of the Japan Pharmaceutical Manufacturers Association for the 3Rs in laboratory animal studies
HIDENORI WATANABE1,2
1JAPAN TOBACCO INC. Central Pharmaceutical Institute, 2Japan Pharmaceutical Manufacturers Association (JPMA)
Alternatives to Animal Testing and Experimentation 19 (suppl) 130-130, 2014.
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S5-1 A seminar on alternatives development in Shiseido with external experts
TAKAO ASHIKAGA
Shiseido Reseach Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 132-132, 2014.
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S5-2 Application of in vitro model for non-animal safety assessment
Morihiko Hirota
Shiseido Research Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 132-132, 2014.
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S5-3 In silico methodology for cosmetic safety assessment
HIROKAZU KOUZUKI
Shiseido Research Center, Shiseido Co.,Ltd
Alternatives to Animal Testing and Experimentation 19 (suppl) 133-133, 2014.
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S5-4 Bayesian Integrated Testing Strategy for Skin Sensitization Potency ; an update
Joanna Jaworska
Procter & Gamble
Alternatives to Animal Testing and Experimentation 19 (suppl) 134-134, 2014.
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S5-5 Reactive oxygen species (ROS) assay for non-animal photosafety assessmentof cosmetics
SATOMI ONOUE
Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 19 (suppl) 135-135, 2014.
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S6-1 Study on usefulness of hepatotoxicity assay using HepaRG cells
TAKAFUMI TOMIDA, YOSHIHIRO KONNO
Pharmacokinetics and Safety Department, Drug Research Center, Kaken Pharmaceutical Co.,LTD.
Alternatives to Animal Testing and Experimentation 19 (suppl) 137-137, 2014.
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S6-2 Involvement of mitochondria to determine the sensitivity of drug-induced liver injury
SHUICHI SEKINE1, TOSHIHARU HORIE2, KOUSEI ITO1
1Graduate school of Pharmaceutical Sciences, Chiba University, 2Teikyo Heisei University
Alternatives to Animal Testing and Experimentation 19 (suppl) 138-138, 2014.
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S6-3 Investigations for biomarkers of idiosyncratic drug-induced liver injury
TSUYOSHI YOKOI
Department of Drug Safety Sciences, Nagoya University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 19 (suppl) 139-139, 2014.
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S6-4 The toxicological application of large-scale database of microRNA
KEIICHI MINAMI
Exploratory Research Laboratories, Tsukuba Research Institute, Ono Pharmaceutical Co., Ltd.
Alternatives to Animal Testing and Experimentation 19 (suppl) 140-140, 2014.
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S6-5 Current situation of the toxicity prediction by large-scale gene expression database
NORIYUKI NAKATSU
Toxicogenomics Informatics Project, National Institute of Biomedical Innovation
Alternatives to Animal Testing and Experimentation 19 (suppl) 141-141, 2014.
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S7-1 Development of Cell-Base Assay Technology for Drug Discovery
TOSHIYUKI KANAMORI
Drug Assay Device Team, Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology
Alternatives to Animal Testing and Experimentation 19 (suppl) 143-143, 2014.
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S7-2 Development and application of an oxygen permeable device for 3D cell culture
TAKAHISA ANADA, JUNJI FUKUDA, OSAMU SUZUKI
Division of Craniofacial Function Engineering, Graduate School of Dentistry, Tohoku University
Alternatives to Animal Testing and Experimentation 19 (suppl) 143-143, 2014.
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S7-3 Introduction and application of novel culture systems for cryopreserved human hepatocytes to DMPK studies in drug discovery
YASUHIRO YAMADA
DMPK Research Laboratories, Research Division, Mitsubishi Tanabe Pharma Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 144-144, 2014.
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S7-4 Establishment of a primary human hepatocyte culture system for functional maintenance of drug metabolizing enzymes with gas-permeable lumox & reg plates and its application to metabolite-induced hepatotoxicity assays
KAZUNOBU AOYAMA1, Akihiko Sumita2, Naomi Kamiguchi3, Teruaki Okuda3, Hideki Hirabayashi1, Toshiya Moriwaki1, Junzo Takahashi1
1Drug Metabolism and Pharmacokinetics Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2Analytical Development Laboratories, Chemistry, Manufacturing and Controls Center, Takeda Pharmaceutical Company Limited, 3Drug Safety Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited
Alternatives to Animal Testing and Experimentation 19 (suppl) 145-145, 2014.
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S8-1 Importance of the school education (from childhood to university) in the development of a bioethics view and a research ethics view
Hajime Shimojo
Graduate school of education, Yokohama National University
Alternatives to Animal Testing and Experimentation 19 (suppl) 147-147, 2014.
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S8-2 Ethical aspects of data handling
ISAO YOSHIMURA
Tokyo University of Science
Alternatives to Animal Testing and Experimentation 19 (suppl) 148-148, 2014.
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S8-3 Changing Social Ethics Toward Animals : What Is A Sensible Approach?
HIROMI KAMEKURA
Japan Anti-Vivisection Association
Alternatives to Animal Testing and Experimentation 19 (suppl) 149-149, 2014.
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S8-4 Attitude of research ethics and bioethics as a toxicological scientist
TAKEMI YOSHIDA1,2
1School of Pharmacy, Showa University, Professor Emeritus, 2Council on Pharmacists Credentials
Alternatives to Animal Testing and Experimentation 19 (suppl) 150-150, 2014.
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S9-1 Development of new testing methods for safety pharmacology using human iPS cells
YASUNARI KANDA
Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 152-152, 2014.
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S9-2 Regeneration of antigen specific T cells using the iPSC technology : - A novel strategy for cancer immunotherapy -
HIROSHI KAWAMOTO
Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University
Alternatives to Animal Testing and Experimentation 19 (suppl) 152-152, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
S9-3 Study for iPS cells derived from intractable diseases
TAKUMI ERA
Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University
Alternatives to Animal Testing and Experimentation 19 (suppl) 153-153, 2014.
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S9-4 A New Approach for 3D Tissue & Organ Fabrication Inspired From Orthopedic Surgery
KOICHI NAKAYAMA
Biomedical Engineering Course Advanced Technology Fusion Graduate School of Science and Engineering
Alternatives to Animal Testing and Experimentation 19 (suppl) 154-154, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
S10-1 The view of safety evaluation utilized in silico
NAOHIRO IKEDA
R & D - Core Technology - Safety Science Research, Kao Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 156-156, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
S10-2 Use of QSAR Tools for Hazard Identification and Control of Genotoxic Impurities in Pharmaceuticals
MASAMITSU HONMA
National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 157-157, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
S10-3 The progress of the OECD QSAR and AOP projects
TAKASHI YAMADA1, YUKI SAKURTANI1,2
1Chemical Management Center, National Institute of Technology and Evaluation, 2OECD
Alternatives to Animal Testing and Experimentation 19 (suppl) 158-158, 2014.
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S10-4 In vitro and in silico study for the evaluation of liver toxicity by chemical substances with liver hypertrophy as an example
KOUICHI YOSHINARI
Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 19 (suppl) 159-159, 2014.
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M-1 Development of in vitro system for searching the circadian clock-regulatory factors responsible for malignant cell transformation
SATORU KOYANAGI
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University
Alternatives to Animal Testing and Experimentation 19 (suppl) 161-161, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
M-2 A plan for development of universal method in skin stimulus measurement using epidermal keratinocyte mitochondria as a forefront of sensory system for homeostasis maintenance
TOSHIHIRO ONA1,2, JUNKO SHIBATA1,2
1Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 2OK Lab.Inc., Cell BET division
Alternatives to Animal Testing and Experimentation 19 (suppl) 162-162, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
M-3 Prediction of the risk of drug-induced cholestasis based on the functional evaluation of bile canalicular transporters in vitro
TAKASHI YOSHIKADO, Yuichi Sugiyama
Sugiyama Laboratory, RIKEN Innovation Center, RIKEN
Alternatives to Animal Testing and Experimentation 19 (suppl) 163-163, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-1 Study of in vitro skin irritation test targeted for sensitive skin (Part 4)
HIDEFUMI IKEDA, HIDEKI NISHIURA
R & D Basic Research, Nihon Kolmar Co.,Ltd.
Alternatives to Animal Testing and Experimentation 19 (suppl) 165-165, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-2 Special Committee's Report - Alternative Primary Irritation Test
SYAMA MARIKO, NORIYASU IMAI, TAKASHI OMORI, SHIGENOBU HAGINO, HIROAKI TODO, AKEMI TOYODA, KENJI SUGIBAYASHI
Special committee on alternative primary irritation test, Japanese Society of Alternatives to Animal Experiments (JSAAE), Tokyo, Japan UGI
Alternatives to Animal Testing and Experimentation 19 (suppl) 165-165, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-3 Development of new in vitro skin irritation test methods by using human epidermis models, EpiSkin(TM) and Skin Ethic RHE(TM), to predict the 24 hours patch test.
MIYUKI FUJISHIRO1, Daiki Kyotani2, Koji Kurihara2, Daisuke Yoshida1, Setsuko Jitsukawa3, Nathalie Alepee4, Jose Cotovio4
1Cosmos Technical Center Co.,Ltd., 2Nikoderm Research Inc., 3NIHON L'OREAL K.K., 4L'OREAL Research & Innovation
Alternatives to Animal Testing and Experimentation 19 (suppl) 166-166, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-4 Differentiation of Muse cells into melanocytes and its application to 3D skin model
XINTIAN LAO1, Kazuki Tatsumi2,3, Mari Dezawa3, Tadayoshi Ueda1, Yoshihiro Sumita1
1DS Pharma Biomedical Co.,Ltd., 2Clio, Inc., 3Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 19 (suppl) 166-166, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-5 Prediction of skin irritation / corrosion potential of chemical using the Reconstructed Human Epidermal model.
RYOJI SAWADA, YUYA IKUTA, TAKASHI MORIMOTO, TAKAFUMI YAMAGUCHI, KUNIFUMI INAWAKA, HASHIHIRO HIGUCHI, SATOSHI KAWAMURA
Sumitomo chemical Co,Ltd., Environmental Health Science Laboratory
Alternatives to Animal Testing and Experimentation 19 (suppl) 167-167, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-6 Basal expression of inflammatory mediators in Keraskin-VM, a reconstructed human epidermis developed in Korea
Jo Ji-Hoon1, Park Jung-Eun1, Lee Soo-Hyun2, Heo Yong1
1Catholic University of Daegu, Dept. Occupational Health, 2Modern Cell & Tissue Technologies, Co., Republic of Korea
Alternatives to Animal Testing and Experimentation 19 (suppl) 167-167, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-7 Study on eye irritation test method using the three-dimensional reconstructed corneal model created using immortalized human corneal epithelial cell line (iHCE-NY) - Development of discriminant method based on the image analysis -
YOSHINAO KATO1, NAOKI YAMAMOTO2, TOSHIO IGARASHI1, ATSUSHI SATO1, SATORU NAKATA1, HAJIME KOJIMA3
1Research Institutes, Nippon Menard Cosmetic Co.,Ltd., 2Fujita Health University Joint Research Laboratory, 3National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 168-168, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-8 Construction of three-dimensional culture model by using SIRC cells and study on the eye irritation test method using the model
TOMOMI MAEDA, YOSHINAO KATO, ATSUSHI SATO, SHUNJI YAMADA, SATORU NAKATA
Research Institutes, Nippon Menard Cosmetic Co.,Ltd.
Alternatives to Animal Testing and Experimentation 19 (suppl) 168-168, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-9 Advantages of the predictive capacity utilizing a Vitrigel-EIT (eye irritancy test) method
HIROYUKI YAMAGUCHI1,3, HAJIME KOJIMA2, TOSHIAKI TAKEZAWA1
1National Institute of Agrobiological Sciences, 2National Institute of Health Sciences, 3Kanto Chemical Co.,Inc.
Alternatives to Animal Testing and Experimentation 19 (suppl) 169-169, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-10 Comparing measurement methods of cell-viability in LabCyte CORNEA - MODEL24
MAI ENDO1, MASAKAZU KATOH2, TAKASHI OMORI1, AIMI YAMASHITA3, HAJIME KOJIMA4, TOSHIHIKO KASAHARA5, HARUNA TAHARA5, SHINSUKE SHINODA6, SAORI HAGIWARA6, HIDEFUMI IKEDA7, YUICHIRO YOSHITAKE8
1Graduate School of Culture and Information Science, Doshisha University, 2Japan Tissue Engineering Co.,Ltd., 3Faculty of Culture and Information Science, Doshisha University, 4National Institute of Health Sciences, 5FujiFilm Co., 6Drug Safety Testing Center Co.,Ltd., 7Nihon Kolmar Co.,Ltd., 8Oppen Cosmetics Co.
Alternatives to Animal Testing and Experimentation 19 (suppl) 169-169, 2014.
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P-11 Transition of the historical control data of the Bovine Corneal Opacity and Permeability (BCOP) test method and analysis of IVIS data of ocular irritants
Takashi Sakakibara, Kouta Itoh, Takuo Nakayama, Miharu Koshita, Souhei Okumura, Kohtaro Kawamura, Masao Matsuura
Safety Research Division, Safety Research Institute for Chemical Compounds Co.,Ltd
Alternatives to Animal Testing and Experimentation 19 (suppl) 170-170, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-12 Validation study of Vitrige-EIT (Eye Irritancy Test) method (2)
Mika Watanabe1, Nicole C.Kleinstreuer2, Michael Schaeffer3, Tae Sung Kim4, Wannhsin Chen5, Takashi Sozu6, Takeru Niitsuma1, Yamashita Kunihiko7, Hiroshi Miyazaki7, Takayuki Fukuda8, Noriko Yamaguchi8, Sho Fujiwara8, Hiroyuki Yamaguchi9,10, Toshiaki Takezawa10, Hajime Kojima11
1Hatano Research Institute, Food and Drug Safety Center, 2National Institute of Environmental Health Sciences, NICEATM, 3Institute of Health and Consumer Protection, EURL-ECVAM, 4National Institute of Food & Drug Safety Evaluation, KoCVAM, 5Industrial Technology Research Institute, 6Kyoto University, 7Daicel Corporation, 8BoZo Research Center Inc., 9Kanto Chemical Co.,Inc., 10National Institute of Agrobiological Sciences, 11National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 170-170, 2014.
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P-13 Modeification of the 3T3 NRU photo-toxicity test conditions for the evaluation of poorly water-soluble substances (part 2)
AKEMI TOYODA1, Maki Sugiyama1, Seiichiro Furihata1, Keiji Nishizumi1, Hiroshi Itagaki2
1Quality Reseach Department, POLA Chemical Industries, INC, 2Yokohama National University
Alternatives to Animal Testing and Experimentation 19 (suppl) 171-171, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-14 Improvement of the ROS assay for comprehensive photosafety assessment of various chemicals
HIROTO OHTAKE, GEN SUZUKI, MASASHI KATO, MASANORI OCHI, YOSHIKI SETO, SATOMI ONOUE
Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 19 (suppl) 171-171, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-15 Development of phototoxicity assay using hESC-derived RPEs
TAKASHI MORI, Tokushige Nakano, Noriyuki Suzuki, Koichi Saito
Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd
Alternatives to Animal Testing and Experimentation 19 (suppl) 172-172, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-16 Cardiotoxicity of captopril in chick embryos
YUJI YOSHIYAMA, TOSHIMI IIZUKA, TAKENORI TAMAKI, HIDETO ARIUMI
Center for Clinical Pharmacy and Clinical Sciences, Kitasato University School of Pharmacy
Alternatives to Animal Testing and Experimentation 19 (suppl) 172-172, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-17 Dual-color fluorescent imaging system for visualization of CYP3A4 and CYP3A7 expression changes in human hepatic carcinoma HepaRG cells
SAORI TSUJI1, FUMIHIKO KAWAMURA2, MUSASHI KUBIURA2, AYAKA HAYASHI2, TETSUYA OHBAYASHI3, YASUHIRO KAZUKI2,4, MITSUO OSHIMURA4, MASAKO TADA4
1Bio Frontier Project Promotion Section, Organization for Tottori Industria lPromition, 2Division of Molecular Genetics and Biofunction, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, 3Division of Laboratory Animal Science, Research Center for Bioscience and Technology, Tottori University, 4Chromosome Engineering Research Center, Tottori University
Alternatives to Animal Testing and Experimentation 19 (suppl) 173-173, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-18 In vitro developmental neurotoxicity testing based on energy metabolism of human multipotent cells
MIKI ASANAGI1,2, SHIGERU YAMADA2, HIROSHI ITAGAKI1, YUKO SEKINO2, YASUNARI KANDA2
1Graduate School of Engineering, Yokohama National University, 2Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 173-173, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-19 Development of an endotoxin detection system using IL-8 reporter cell.
YUTAKA KIMURA, CHIZU FUJIMURA, SETSUYA AIBA
Department of Dermatology, Tohoku University Graduate School of Medicine
Alternatives to Animal Testing and Experimentation 19 (suppl) 174-174, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-20 Rapid in vivo-like cell-based assay of epidermis pro-turnover efficacy with toxicity by homogenized Kiwi fruits
TOSHIHIRO ONA1,2, JUNKO SHIBATA1,2, AKIO HAYAKAWA3, SHINYA SAKAMOTO4
1Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 2OK Lab. Incorporation, Cell BET Division, 3Kohkan Pharmaceutical Institute Company Limited, 4Agri Company Limited
Alternatives to Animal Testing and Experimentation 19 (suppl) 174-174, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-21 In vitro anti-thrombotic evaluation of biomaterials by using the ATP assay
NAOAKI ISHINO1,2, Toshia Fujisato1
1Graduate School of Engineering, Osaka Institute of Technology, 2Department of Medical Engineering, Aino university
Alternatives to Animal Testing and Experimentation 19 (suppl) 175-175, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-22 Study of alternative methods using silkworm for mammalian efficacy tests
TAKUYA SUGITA, TAKURO UEKI, YUTAKA YAMAMOTO, HIDENOBU OKUMURA
Noevir Co.,Ltd
Alternatives to Animal Testing and Experimentation 19 (suppl) 175-175, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-23 Study of general versatility on the acute oral toxicity test using silkworm
TAKURO UEKI, TAKUYA SUGITA, YUTAKA YAMAMOTO, HIDENOBU OKUMURA
Noevir Co.,Ltd., Groupwide Research and Development
Alternatives to Animal Testing and Experimentation 19 (suppl) 176-176, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-24 An efficient and reliable method for generation of Mesenchymal Progenitors from human gingiva-derived iPS cells
YASUYUKI UMEZAKI1, YOSHIYA HASHIMOTO2, NAOKI NISHISHITA3, SHIN KAWAMATA3, SHUNSUKE BABA1
1Department of Oral Implantology, Osaka Dental University, 2Department of Biomaterials, Osaka Dental University, 3Research and Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation
Alternatives to Animal Testing and Experimentation 19 (suppl) 176-176, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-25 Application to the agent screening for overcoming drug resistance by using 3D culture of human hepatoma cells
TAKU MATSUSHITA, Takahiro Mizutami, Yuya Ohta, Takaaki Ishii, Yuji Komizu
Department of Applied Life Science, Sojo University
Alternatives to Animal Testing and Experimentation 19 (suppl) 177-177, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-26 Hepatotoxic drugs-induced metabolic-dependent mitochondrial toxicity
MAHO SHIRAKAWA1, SHUICHI SEKINE2, AYAKA TAKANA1, TOSHIHARU HORIE3
1Department of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Chiba University, 2Department of Biopharmaceutics, Graduate school of Pharmaceutical Sciences, Chiba University, 3Faculty of Pharmacy, Teikyo-Heisei University
Alternatives to Animal Testing and Experimentation 19 (suppl) 177-177, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-27 Optimization of cell-based assay for Assessment of Mitochondrial Dysfunction induced Hepatotoxicity
CONG LIU, Shuichi Sekine, Kousei Ito
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 19 (suppl) 178-178, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-28 Evaluation of lactic acid bacteria activating innate immunity using silkworm
SATOSHI NISHIDA1, KENNICHI ISHII2, HIROSHI HAMAMOTO2, KAZUHISA SEKIMIZU1,2
1Genome Pharmaceuticals Institute Co.,Ltd, 2Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 19 (suppl) 178-178, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-29 Multi-walled carbon nanotubes (MWCNTs) to normal myocardial contraction rhythms on differentiation of ES-D3 cells in three-dimensional culture
Koichi IMAI1, Tsubasa SHIRAI1, Fumio WATARI2
1Department of Biomaterials, Osaka Dental University, 2Graduate School of Dental Medicine, Hokkaido University
Alternatives to Animal Testing and Experimentation 19 (suppl) 179-179, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-30 Influence of the mouse ES cell culture with scaffold for the regenerative medicine using collagen derived from Tilapia scales
Koichi IMAI, Tsubasa SHIRAI
Department of Biomaterials, Osaka Dental University
Alternatives to Animal Testing and Experimentation 19 (suppl) 179-179, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-32 Screening of suitable chemicals for in vitro hepatotoxicity test
SHINOBU WAKURI, KIYOSHI SASAKI, MAIKO GONDO, NOBUKO ENDO, HAJIME SUI, KOHJI YAMAKAGE
Division of Alternative Toxicology Test, Hatano Institute, Food and Drug Safety Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 180-180, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-34 Comparison of 3 criteria incorporating variation of index for toxicity of the interleukin 8 luciferase Luc assay (IL-8 Luc assay)
AOI MARUYA1, AIBA SETSUYA2, YUTAKA KIMURA2, MIKA WATANABE3, NORIYUKI SUZUKI4, KOHJI YAMAKAGE3, KOICHI SAITO4, YOSHIHIRO NAKAJIMA5, YOSHIHIRO OHMIYA6, SHOJIRO YAMAZAKI3, HAJIME KOJIMA7, NIRIHO TANAKA3, HITOSHI SAKAGUCHI8, HIROSHI ITAGAKI9, MAYUMI KOBAYASHI1, AZUSA MORI1, TAKASHI OMORI1
1Faculy of Culture and Information Science, Doshisya University, 2Dermatology, Tohoku University Graduate School of Medicine, 3Hatano Research Institute, Food and Drug Safety Center, 4Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd., 5Health Research Institute, Advanced Industrial Science and Technology, 6Biomedical Research Institute, Advanced Industrial Science and Technology, 7Japanese Center for the Validation of Alternative Methods, 8Kao, 9Yokohama National University
Alternatives to Animal Testing and Experimentation 19 (suppl) 180-180, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-35 An inter-laboratory validation study and creation of a dataset of IL-8 Luc assay
YUTAKA KIMURA1, MIKA WATANABE2, NORIYUKI SUZUKI3, TOMOKO IWAKI4, KOHJI YAMAKAGE2, KOICHI SAITO3, YOSHIHIRO NAKAJIMA4, CHIZU FUJIMURA1, YOSHIHIRO OHMIYA5, AYAKO SAKAI2, AOI MARUYA6, TAKASHI OMORI6, SHOJIRO YAMAZAKI7, HAJIME KOJIMA8,9, NORIHO TANAKA7, SETSUYA AIBA1
1Department of Dermatology, Tohoku University Graduate School of Medicine, 2Hatano Research Institute, Food and Drug Safety Center, 3Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd., 4Health Research Institute, Advanced Industrial Science and technology, 5Biomedical Research Institute, Advanced Industrial Science and Technology, 6Faculty of Culture and Information Science, Doshisha University, 7Organization for Tottori Industrial Promotion, 8Japanese Center for the Validation of Alternative Methods (JaCVAM), 9National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 181-181, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-36 An easy method for estimation of the half-maximal inhibitory concentration using curve fitting appropriate to the concentration-response relationship
AZUSA MORI1, NORIYUKI SUZUKI2, LE COZ FLORIAN2, HIROHISA NAGAHORI2, KOICHI SAITO2, MAYUMI KOBAYASHI1, AOI MARUYA1, TAKASHI OMORI1
1Faculty of Culture and Information Science, Doshisha University, 2Environmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd
Alternatives to Animal Testing and Experimentation 19 (suppl) 181-181, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-37 Relationship between IC50 and ID50 value in the Hand1-Luc Embryonic Stem cell Test (Hand1-Luc EST)
MAYUMI KOBAYASHI1, NORIYUKI SUZUKI2, LE COZ FLORIAN2, HIROHISA NAGAHORI2, KOICHI SAITO2, AZUSA MORI1, AOI MARUYA1, TAKASHI OMORI1
1Faculty of Culture and Information Science, Doshisha University, 2Emvironmental Health Science Laboratory, Sumitomo Chemical Co.,Ltd
Alternatives to Animal Testing and Experimentation 19 (suppl) 182-182, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-38 Hazard Evaluation Support System Integrated Platform (HESS) - Evaluation of sensitivity to address renal toxicity -
JUNKO OHUCHI1, Naohiro Ikeda1, Yuki Sakuratani2, Takashi Yamada2, Naohiro Nishiyama1
1R & D - Core Technology - Safety Science Research, Kao Corporation, 2Chemical Management Center, National Institute of Technology and Evaluation (NITE)
Alternatives to Animal Testing and Experimentation 19 (suppl) 182-182, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-39 A proposal of a risk-warning method for reporting adverse events - An application Baysian statistics -
AIMI YAMASHITA, TAKASHI OMORI
Faculty of Culture and Information Science, Doshisha University
Alternatives to Animal Testing and Experimentation 19 (suppl) 183-183, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-40 Quantitative risk vs. risk trade-off analysis and a quantitative activity-activity relationship (QAAR) model
JUN-ICHI TAKESHITA, MASASHI GAMO
Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology (AIST)
Alternatives to Animal Testing and Experimentation 19 (suppl) 183-183, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-41 Skin sensitization model based on only animal data by qualitative structure-toxicity relationships (QSTR) approach
KAZUHIRO SATO1, Kotaro Yuta2, Yukinori Kusaka1
1Department of Environmental Health, School of Medicine, University of Fukui, 2In Silico Data
Alternatives to Animal Testing and Experimentation 19 (suppl) 184-184, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-42 Approach to the Reproduction / Developmental Toxicity Assessment for Cosmetic Ingredients Using In silico Method
HIROKAZU KOUZUKI, TOMOKA HISAKI, MAKI AIBA, MASAHIKO YAMAGUCHI, TAKAO ASHIKAGA
SHISEIDO CO.,LTD. Quality Assessment Center, Safety Research & Development Laboratories
Alternatives to Animal Testing and Experimentation 19 (suppl) 184-184, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-43 Establishing an in silico prediction system of nine major in vivo drug clearance pathway using machine learning technique
KOTA TOSHIMOTO1, NAOMI WAKAYAMA2, SHUN HOTTA3, KAZUYA MAEDA4, TAKASHI ISHIDA3, YUTAKA AKIYAMA3, YUICHI SUGIYAMA1
1Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 2Drug Metabolism and Pharmacokinetics Research Section, Eisai Co., Ltd, 3Department of Computer Science, Graduate School of Information Science and Engineering, Tokyo Institute of Technology, 4Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
Alternatives to Animal Testing and Experimentation 19 (suppl) 185-185, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-44 Studies on the fusion of in silico toxicity prediction and alternatives to animal experiments : Development of two-class classification methods that specializes in toxicity prediction
KOHTARO YUTA
In silico data, Ltd.
Alternatives to Animal Testing and Experimentation 19 (suppl) 185-185, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-45 Development of iv vitro alveolar model using human cell lines and rat primary cells and the combination use of the numerical model for the assessment of nanoparticle toxicity
KOKORO IWASAWA1, Kodai Harano1, Rie Ogasawara2, Naohide Shinohara3, Guihua Zhang3, Masashi Gamo3, Akira Suwabe2, Yasuyuki Sakai1
1Institute of Industrial Science, the University of Tokyo, 2School of Medicine, Iwate Medical University, 3National Institute of Advanced Industrial Science and Technology
Alternatives to Animal Testing and Experimentation 19 (suppl) 186-186, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-46 A novel THP-1-based reporter cell line, ITRI-54M, for in vitro screening of skin sensitizers
Zong-Keng Kuo1, Wen-Sheng Chiang2, Huey-Min Lai2, Hsiang-Wen Tseng2
1Quality Research Department, POLA Chemical Industries, INC, 2Biomedical Technology and Device Research Labs, Industrial Technology Research Institute
Alternatives to Animal Testing and Experimentation 19 (suppl) 186-186, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-47 Study on reproducibility of SH test for predicting skin sensitization potency.
MAKI SUGIYAMA1, KAORU KASAHARA1, AKEMI TOYODA1, KENJI NISHISUMI1, MORIHIKO HIROTA2, TAKAO ASHIKAGA2, HIROKAZU KOUZUKI2
1Quality Research Department, POLA CHEMICAL INDUSTRIES, INC., 2Shiseido Research Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 187-187, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-48 Investigation of the Short Time Exposure to assess water-insoluble chemicals in vitro skin sensitization test
KAZUTO NARITA1, Hajime Kojima2, Hiroshi Itagaki1
1Yokohama national university, 2National institute of health sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 187-187, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-49 Development of a novel in vitro skin sensitization assay with reconstructed human epidermis. 〜Analysis of expression mechanism of marker genes and assessment of predictivity to animal testing〜
KAZUTOSHI SAITO, OSAMU TAKENOUCHI, TAKU NISHIJO, MASAAKI MIYAZAWA, HITOSHI SAKAGUCHI
Kao Corporation, R & D - Safety Science Research
Alternatives to Animal Testing and Experimentation 19 (suppl) 188-188, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-50 Improvement of alternative skin sensitization test method using vitrigel chamber (Vitirgel-SST method)
Tadashi Uchino1, Hiroshi Miyazaki2, Kunihiko Yamashita2, Hajime Kojima1, Toshiaki Takezawa3, Noriko Yamaguchi4, Maki Nakamura5, Masayuki Takaishi6, Takumi Akiyama1, Yosiaki Ikarashi1
1National Institute of Health Sciences, 2Daicel Corporation, 3National Institute of Agrobiological Sciences, 4BoZo Research Center Inc., 5Kobayashi Pharmaceutical Co.,Ltd., 6Mandom Corp.
Alternatives to Animal Testing and Experimentation 19 (suppl) 188-188, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-51 Development of non-animal skin sensitization testing strategy applicable to various cosmetic ingredients
TAKU NISHIJO, KAZUTOSHI SAITO, MASAAKI MIYAZAWA, HITOSHI SAKAGUCHI
Safety Science Research, Kao Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 189-189, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-52 Conditioning of DPRA concerning peptide stability
SHIHO OEDA, Takao Ashikaga, Morihiko Hirota, Akira Motoyama, Hirokasu Kozuki
Safety Technology Development Group, Shiseido Reserch Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 189-189, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-53 Verification of a skin sensitization assessment neural network model by fragrance materials
TOMOMI ATOBE1, MORIHIKO HIROTA1, TAKAO ASHIKAGA1, Api Anne Marie2, Lalko Jon2
1Shiseido Research Center, 2Reserch Institute for Fragrance Materials, Inc
Alternatives to Animal Testing and Experimentation 19 (suppl) 190-190, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-54 Value of interleukin-1α and interleukin-6 for development of a skin sensitization alternative method using HaCaT human keratinocyte cell line
Park Jung-Eun1, Jo Ji-Hoon1, Jung Da-Wn2, Seok Seung-Hyeok2, Heo Yong1
1Catholic University of Daegu, Dept. Occupational Health, 2Department of Microbiology and Immunology, College of Medicine, Seoul National University
Alternatives to Animal Testing and Experimentation 19 (suppl) 190-190, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-55 Novel techniques for the prediction of skin sensitization using compound concentrations 2 orders of magnitude less than those used in conventional methods
YUSUKE YAMAMOTO1, TOSHIHIKO KASAHARA1, YOSHIHIRO JIMBO2, TAKANORI HIOKI1, MASAHARU FUJITA1
1Safety Evaluation Center, Ecology & Quality Management Div., Csr Div, FUJIFILM Corporation, 2Synthetic Organic Chemistry Laboratories, Research & Development Management Headquarters, FUJIFILM Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 191-191, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-56 Evaluation of skin sensitizer by a novel skin sensitization test using collagen vitrigel membrane chambers
Hiroshi MIYAZAKI1, Kunihiko YAMASHITA1, Tadashi UCHINO2, Hajime KOJIMA2, Toshiaki TAKEZAWA3
1Corporate Research Center, Daicel corporation, 2National Institute of Health Sciences, 3National Institute of Agrobiological Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 191-191, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-57 Development of a Local Lymph Node Assay Modified by Diacel Based on ATP Content Elicitation (LLNA : DAE) method (second report)
Kunihiko Yamashita1,3, Shinsuke Shinoda2, Saori Hagiwara2, Hiroshi Itagaki3
1Corporate Research Center, Daicel Corporation, 2Yoshimi Laboratories, Drug Safety Testing Center Co.,Ltd., 3Faculty of Engineering, Dept. of Materials Science and Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 19 (suppl) 192-192, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-58 Generation of luciferase-expressing-cell line using artificial chromosome vector
Yoshihiro Nakajima1, Mayu Yasunaga1, Kazutoshi Murotomi1, Tetsuya Ohbayashi2, Mitsuo Oshimura3
1Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2Research Center for Bioscience and Technology, Tottori University, 3Chromosome Engineering Research Center, Tottori University
Alternatives to Animal Testing and Experimentation 19 (suppl) 192-192, 2014.
  • 全文ダウンロード: 従量制、基本料金制の方共に121円(税込) です。
P-59 Fundamental study of the SH test in skin sensitization assay
MIKA TSURUMAKI, Sakiko Aizawa, Noriyasu Imai, Masato Nakade
KOSE Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 193-193, 2014.
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P-60 Genomic / Epigenomic analyses of differentiation of HepaRG human hepatocyte progenitor cells
SEIICHI ISHIDA1, HELENE SCHNEIDER2, TAKASHI KUBO1, TAMAKI HORI1, SHINICHIRO HORIUCHI1, YUKIE KURODA1, SU-RYANG KIM1, ANNE CORLU2, FABRICE MOREL2, YUKO SEKINO1
1Department of Pharmacology, National Institute of Health Sciences, 2INSERM UMR991
Alternatives to Animal Testing and Experimentation 19 (suppl) 193-193, 2014.
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P-61 Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism
ARAKAWA HIROSHI1,11, Takako Ohkura2,11, Kunihiro Ohta3,11, Takuya Nagao4,11, Kumiko Kusumoto5,11, Akiko Koeda6,11, Tadayoshi Ueda7,11, Tomoko Jomura8,11, Takeshi Ikeya8,11, Emiko Ozeki8,11, Yukiko Inoue11, Naoki Takahashi9,11, Hisakazu Iwai10,11, Takuo Ogihara1,11
1Faculty of Pharmacy, Takasaki University of Health and Welfare, 2Maruishi Pharmaceutical Co.,Ltd., 3Chugai Pharmaceutical Co.,Ltd., 4Sumika Chemical Analysis Service, Ltd., 5Osaka City University Medical School, 6Ina Research Inc.,Ltd., 7DS Pharma Biomedical Co.,Ltd., 8Toyo Gosei Co.,Ltd., 9Sanwa Kagaku Kenkyusho Co.,Ltd., 10Sanwa Kagaku Kenkyusho Co.,Ltd., 11Spheroid Working Group in Safety Evaluation Forum
Alternatives to Animal Testing and Experimentation 19 (suppl) 194-194, 2014.
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P-62 Differentiation Muse cells into Hepatocytes and its maturation using miRNA
KAZUSHI KAWAHARADA1, Tadayoshi Ueda1, Yoshihiro Sumita1, Mieko Otsu2,3, Hideo Akashi3, Mari Dezawa3, Luc Gailhouste4, Takehiro Ochiya4
1DS Pharma Biomedical Co.,Ltd., Product Management and Business Development, Research and Development Division, 2Clio, Inc., 3Departments of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, 4Division of Molecular and Cellular Medicine, National Cancer Center Research Institute
Alternatives to Animal Testing and Experimentation 19 (suppl) 194-194, 2014.
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P-63 Metabolome analysis and toxicity test of human fetal and adult hepatocytes
TAKU MATSUSHITA1, Yudai Ichikawa1, Takaaki Ishii1, Yuji Komizu1, Su-Ryang Kim2, Seiichi Ishida2, Atsuko Miyajima3, Yuko Sekino2
1Department of Applied Life Science, Sojo University, 2Division of pharmacology, National Institute of Health Sciences, 3Division of Medical Devices, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 195-195, 2014.
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P-64 A novel culture method of HepG2 cells useful for the analyses of pharmacokinetics : Sandwich-co-culture system involving endothelial cells on the liquid-gas interface utilizing a collagen vitrigel membrane chamber
AYUMI OSHIKATA1, SEIICHI ISHIDA2, YUKIE KURODA2, TOSHIAKI TAKEZAWA1
1Division of Animal Sciences, National Institute of Agrobiological Sciences, 2Division of Pharmacology, National Institute of Health Sciences
Alternatives to Animal Testing and Experimentation 19 (suppl) 195-195, 2014.
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P-65 Prediction of transporter - and enzyme-mediated complicated drug-drug interaction : taking Cerivastatin, withdrawn from the market due to its induced rhabdomyolysis as an example of victim drug
SOO-JIN KIM1, Yoshiaki Yao2, Kota Toshimoto1, Takashi Yoshikado1, Yuichi Sugiyama1
1Sugiyama Lab., RIKEN Innovation Center, RIKEN, 2Analysis & Pharmacokinetics Research Labs., Drug Discovery Research, Astellas Pharma Inc.
Alternatives to Animal Testing and Experimentation 19 (suppl) 196-196, 2014.
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P-66 Prediction of drug transfer into milk taking into consideration the transporter-mediated transfer process
KOUSEI ITO1, NAOKI ITO2, YUKI IKEBUCHI3, YU TOYODA3, TAPPEI TAKADA3, AKIHIRO HISAKA4, AKIRA OKA2, HIROSHI SUZUKI3
1Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, 2Department of Pediatrics, The University of Tokyo Hospital, 3Department of Pharmacy, The University of Tokyo Hospital, 4Laboratory of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University
Alternatives to Animal Testing and Experimentation 19 (suppl) 196-196, 2014.
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P-67 Prediction of the rate-limiting step in the hepatic elimination of statins using sandwich-cultured human hepatocytes
TAKASHI YOSHIKADO1, Rafal P.Witek2, Yuichi Sugiyama1
1Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 2R & D, ADME/T Biosciences, Life Sciences Solutions, Thermo Fisher Scientific
Alternatives to Animal Testing and Experimentation 19 (suppl) 197-197, 2014.
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P-68 A mechanism enhancing macromolecule transport induced by poly-L-arginine in Caco-2 cell monolayers : Analysis of disappearance of tight junction proteins from cell-cell junctions
TSUTOMU YAMAKI, YUSUKE KAMIYA, KAZUO OHTAKE, MASAKI UCHIDA, TOSHINOBU SEKI, HIDEO UEDA, JUN KOBAYASHI, YASUNORI MORIMOTO, HIDESHI NATSUME
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 19 (suppl) 197-197, 2014.
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P-69 Suitability of PDMS/PEG copolymer-impregnated membranes for prediction of drug permeation from transdermal products
SOICHIRO KIMURA, RYOTARO MIKI, YUYA EGAWA, HIDESI NATSUME, TOSHINOBU SEKI, YASUNORI MORIMOTO, HIDEO UEDA
Faculty of Pharmaceutical Sciences, Josai University
Alternatives to Animal Testing and Experimentation 19 (suppl) 198-198, 2014.
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P-70 The comparison of novel dressings in vitro drug release testing
WENYi KAO, HUIYING LEE, SHIHCHING HO
Department of Pharmacology, Institute for Drug Evaluation Platform, Development Center for Biotechnology
Alternatives to Animal Testing and Experimentation 19 (suppl) 198-198, 2014.
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P-71 Animal Alternative Test Researches in SCDC
Ping Xiao
Quality Research Department, POLA Chemical Industries, INC.
Alternatives to Animal Testing and Experimentation 19 (suppl) 199-199, 2014.
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P-72 Usage of a hyperglycemic silkworm model for evaluation of anti-diabetic drugs
YASUHIKO MATSUMOTO, KAZUHISA SEKIMIZU
Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, University of Tokyo
Alternatives to Animal Testing and Experimentation 19 (suppl) 199-199, 2014.
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P-73 JSAAE activities for WC9
Kokusaikoryuiinkai Nihondoubutsujikkendaitaihogakkai
Kokusaikoryuiinkai Nihondoubutsujikkendaitaihogakkai
Alternatives to Animal Testing and Experimentation 19 (suppl) 200-200, 2014.
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P-74 JaCVAM update
Hajime Kojima1, Akiyoshi Nishikawa2
1National Center for Biological Safety and Research (BSRC), National Institute of Health Sciences (NIHS), 2Japanese Center for the Validation of Alternative Methods (JaCVAM)
Alternatives to Animal Testing and Experimentation 19 (suppl) 200-200, 2014.
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P-75 In Hepatotoxicity evaluation system construction which does not use the animal by the combination of silico and in vitro
NAOHIRO IKEDA, MIZUKI SONE, JOSHOU RYUU, HIROTO BUSHITA, JUNKO OHUCHI, NAOHIRO NISHIYAMA
R & D - Core Technology - Safety Science Research, Kao Corporation
Alternatives to Animal Testing and Experimentation 19 (suppl) 201-201, 2014.
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P-76 Development of alternative tests for reproductive and developmental toxicity : whole embryo culture in humanized CYP3A (CYP3A-HAC) mice
MASAHARU AKITA1, Yasuhiro Kazuki2,6, Noriko Ishizuka3, Atsushi Yokoyama4, Tetsuya Kamataki5, Mitsuo Oshimura6
1Department of Nutrition and Dietetics Kamakura Women's University, 2Graduate School of Medical Sciences, Tottori University, 3Department of Registered Dietitians, Tokai Gakuin University, 4Life Science Laboratory of Kanagawa, 5Graduate School of Pharmaceutical Sciences, Hokkaido University, 6Tottori University Chromosome Engineering Research Center
Alternatives to Animal Testing and Experimentation 19 (suppl) 201-201, 2014.
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P-77 Effects of kumisukutine on cultured rat embryos.
ATYUSHI YOKOYAMA1, MASAHARU AKITA2
1Kanagawa Life-Science Research, 2Kamakura Woman College
Alternatives to Animal Testing and Experimentation 19 (suppl) 202-202, 2014.
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P-78 Prediction of chemical-inducing hepatocyte hypertrophy in rats in vivo based on in vitro reporter assays
HIROYUKI NAKAJIMA1,2, ATSUSHI MATSUZAWA1, KOUICHI YOSHINARI1,2
1Laboratory of Health Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 2Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 19 (suppl) 202-202, 2014.
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P-79 Construction of a toxicity test database of pesticides for the toxicological characterization of hepatocyte hypertrophy
MIYABI MASUDA, MASASHI SEKIMOTO, KIYOMITSU NEMOTO, KOUICHI YOSHINARI
Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka
Alternatives to Animal Testing and Experimentation 19 (suppl) 203-203, 2014.
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P-80 Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes
TAKESHI SUSUKIDA1, Shuichi Sekine1, Eiichiro Ogimura1, Shigeki Aoki1, Toshiharu Horie2, Kousei Ito1
1Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 2Faculty of Pharmaceutical Sciences, Teikyo Heisei University
Alternatives to Animal Testing and Experimentation 19 (suppl) 203-203, 2014.
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P-81 Construction of the co-cultured hepatocyte spheroids by microwell chip
TAKASHI MORIKYO, Kohji Nakazawa
Department of Life and Environment Engineering, The University of Kitakyushu
Alternatives to Animal Testing and Experimentation 19 (suppl) 204-204, 2014.
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P-82 Confirmation of anticancer drug resistance mechanism using silicate fiber based 3D cell culture
SHINYA KOGA1, YOSHIE YAMAGUCHI1, DAWEI DENG1, YOSHINORI SATO1, YUNG-TE HOU1, RIE WATANABE2, KOHEI SASAKI2, MASAAKI KAWABE2, EIICHI HIRANO1, TETSUO MORINAGA1
1Japan Bio Products Co.,Ltd., 2Japan Vilene Company Ltd.
Alternatives to Animal Testing and Experimentation 19 (suppl) 204-204, 2014.
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P-83 Fabrication of liver-like tissues in collagen gel beads
JUNKO ENOMOTO, TATSUYA OSAKI, JUNJI FUKUDA
Graduate School of Engineering, Yokohama National University
Alternatives to Animal Testing and Experimentation 19 (suppl) 205-205, 2014.
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P-84 Establishment a multicellular 3D liver model by co-culturing rat hepatocytes with TMNK-1 based on gas-permeable membranes for drug screening
WENJIN XIAO1, Guillaume Perry1,2, Kikuo Komori1, Yasuyuki Sakai1
1Institute of Industrial Science, University of Tokyo, 2Laboratory of Integrated Micro-Mechatronic Systems / CNRS, Institute of Industrial Science, University of Tokyo
Alternatives to Animal Testing and Experimentation 19 (suppl) 205-205, 2014.
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P-85 Electrochemical Cell Detachment using Zwitterionic Oligopeptides
TAKAHIRO KAKEGAWA1,2, Gautieri Alfonso3, Junji Fukuda2
1Graduate School of Pure and Applied Sciences, University of TSukuba, 2Graduate School of Engineering, Yokohama National University, 3Department of Electronics, Information and Bioengineering, Politecnico di Milano
Alternatives to Animal Testing and Experimentation 19 (suppl) 206-206, 2014.
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P-86 3D Culture of iPS cells under Pseudo Microgravity by RWV Bioreactor
TOSHIMASA UEMURA1, YUI ONOMURA1, HANHSIU HSU1, TAKASHI TSUMURA2
1National Institute of Advanced Industrial Science and Technology, 2JTEC Osaka Japan
Alternatives to Animal Testing and Experimentation 19 (suppl) 206-206, 2014.
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P-87 Rapid micromolding of osteon-like tissues
TATSUTO KAGEYAMA1, TAKAHIRO KAKEGAWA1,2, TATSUYA OSAKI1,2, TAICHI ITO3, JUNJI FUKUDA1
1Graduate School of Engineering, Yokohama National University, 2Graduate School of Pure and Applied Sciences, University of Tsukuba, 3Center for Disease Biology and Integrative Medicine, University of Tokyo
Alternatives to Animal Testing and Experimentation 19 (suppl) 207-207, 2014.
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P-88 Formation of co-cultured hepatocyte aggregates on oxygen permeable microwells and the evaluation of their tissue polarity
MARIE SHINOHARA, KIKUO KOMORI, YASUYUKI SAKAI
Institute of Industrial Science, the University of Tokyo
Alternatives to Animal Testing and Experimentation 19 (suppl) 207-207, 2014.
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P-89 Long term culture of human hepatocytes using hollow fiber type three dimensional culture module for application to the evaluation of drug toxicity
TAKAAKI ISHII1, Taku Matsushita1, Yuji Komizu1, Mamiko Yanagi2, kenjiro Ikuta2, Kouji Kusaka2
1Department of Applied Life Science, Sojo University, 2Yokohama Laboratories, Mitsubishi RAYON Co.,LTD
Alternatives to Animal Testing and Experimentation 19 (suppl) 208-208, 2014.
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