Japanese

Title	牛における1,25−dihydroxyvitamin D3の経皮吸収
Subtitle	原著
Authors	浪岡徹1), 山岸則夫1), 大倉徳太2), 赤坂茂3), 阿部岳3), 千田広幸3), 佐藤繁1), 内藤善久4)
Authors (kana)
Organization	1)岩手大学農学部獣医学課程大動物診断治療学研究室, 2)上川中央農業共済組合中央家畜診療所, 3)岩手大学農学部附属寒冷フィールドサイエンスセンター, 4)岩手大学農学部附属動物医学食品安全教育研究センター
Journal	日本家畜臨床学会誌
Volume	31
Number	1
Page	1-5
Year/Month	2008 / 4
Article	原著
Publisher	日本家畜臨床学会
Abstract	「要約」牛における1,25（OH）2D3の経皮吸収とその効果を明らかにする目的で, ジャージー種育成牛を用いて尾根部腹側皮膚への1,25（OH）2D3皮膚滴下試験を実施した. 1,25（OH）2D3皮膚滴下群の血漿中1,25（OH）2D3濃度は滴下後2時間から有意に上昇し, 12時間をピークとしてその後低下した. 血漿中Ca濃度は滴下後2〜4時間まで一過性に上昇し, 12〜72時間まで再び有意な高値で推移した. 血漿中iP濃度は, 滴下後24〜120時間まで有意な高値で推移した. 以上の所見は, 1,25（OH）2D3の経皮吸収と生理活性を示すものと考えられた.
Practice	自然科学ほか
Keywords	分娩性低カルシウム血症, 経皮吸収, 1,25−dihydroxyvitamin D3, parturient hypocalcemia, transdermal absorption

English

Title	Transdermal absorption of 1, 25-dihydroxyvitamin D3 in cattle
Subtitle
Authors	T.Namioka1), N.Yamagishi1), N.Okura2), S.Akasaka3), T.Abe3), H.Chida3), S.Sato1), Y.Naito4)
Authors (kana)
Organization	1)Research Unit for Large Animal Internal Medicine & Surgery, Department of Clinical Veterinary Medicine, Faculty of Agriculture, Iwate University, 2)Central Veterinary Clinical Center, Kamikawa Chuo Agricultural Mutual Aid Association, 3)Field Science Center, Faculty of Agriculture, Iwate University, 4)Food Animal Medicine & Food Safety Research Center, Faculty of Agriculture, Iwate University
Journal	Japanese Journal of Large Animal Clinics
Volume	31
Number	1
Page	1-5
Year/Month	2008 / 4
Article	Original article
Publisher	Japanese Society of Large Animal Clinics
Abstract	To determine the transdermal absorption of 1,25(OH)2D3 and its effects, 1,25(OH)2D3, solutions were applied drop-wise onto the skin of the ventral root of the tail (1,25(OH)2D3 treatment) of five growing Jersey cattle. The plasma concentrations of 1,25(OH)2D3 in the 1,25(OH)2D3-treated animals increased significantly from 2 hours after the treatment, peaked at 12 hours, and fell thereafter. There was a transient increase in the plasma Ca concentration during 2 to 4 hours post-treatment, and it remained significantly higher during 12 to 72 hours. The iP concentration in the plasma was significantly higher during 24 to 120 hours post-treatment. These observations appear to be evidence for transdermal absorption of 1,25(OH)2D3 and its physiological activity in cattle.
Practice	Science
Keywords	parturient hypocalcemia, transdermal absorption, 1,25-dihydroxyvitamin D3

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