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Title IPMNの多様性
Subtitle 特集 膵腫瘍の分子多様性〜病態の不均一性を紐解く〜
Authors 大森優子1〜3), 古川徹1)
Authors (kana)
Organization 1)東北大学大学院医学系研究科病態病理学分野, 2)手稲渓仁会病院病理診断科, 3)札幌東徳洲会病院医学研究所
Journal 胆と膵
Volume 45
Number 7
Page 735-740
Year/Month 2024 / 7
Article 報告
Publisher 医学図書出版
Abstract 「要約」 : 膵管内乳頭粘液性腫瘍 (intraductal papillary mucinous neoplasm : IPMN) は組織学的に多彩な腫瘍である. 腫瘍の異型度は, 低異型度腫瘍から高異型度腫瘍へ上昇し, IPMN由来浸潤癌が発生する. 腫瘍性上皮の形質から, 胃型, 腸型, 膵胆道型の亜型に分類され, それぞれ発育進展様式や異型度, 予後に特徴がある. さらに, IPMN患者には同時性, 異時性に浸潤性膵管癌 (併存膵癌) が発生する. IPMN関連膵癌の形成には, sequential, de novo, branch-offの三つの分子経路が存在する.
Practice 臨床医学：内科系
Keywords 胃型IPMN, 腸型IPMN, 膵胆道型IPMN, IPMN関連膵癌
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参考文献

  • 1) Kanda M, Matthaei H, Wu J, et al.: Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia. Gastroenterology 142 : 730-733. e9, 2012.
  • 2) Amato E, Dal Molin M, Mafficini A, et al.: Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neo-plasms of the pancreas. J Pathol 233 : 217-227, 2014.
  • 3) Furukawa T, Kuboki Y, Tanji E, et al.: Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pan-creas. Sci Rep 1 : 161, 2011.
  • 4) Wu J, Jiao Y, Dal Molin M, et al.: Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiqui-tin-dependent pathways. Proc Natl Acad Sci USA 108 : 21188-21193, 2011.
  • 5) Basturk O, Esposito I, Fukushima N, et al.: Pancreatic intraductal papillary mucinous neoplasm. In : The WHO classification of tumours editorial board eds. WHO classification of tumours. 5th ed. vol.1 Diges-tive system tumours., 310-314, IARC Press, Lyon, 2019.
残りの30件を表示する
  • 6) Tanaka M, Fernandez-Del Castillo C, Kamisawa T, et al.: Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pan-creas. Pancreatology 17 : 738-753, 2017.
  • 7) Yamaguchi K, Kanemitsu S, Hatori T, et al.: Pancre-atic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. Pancreas 40 : 571-580, 2011.
  • 8) Furukawa T, Hatori T, Fujita I, et al.: Prognostic relevance of morphological types of intraductal papil-lary mucinous neoplasms of the pancreas. Gut 60 : 509-516, 2011.
  • 9) Mino-Kenudson M, Fernandez-del Castillo C, Baba Y, et al.: Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and pre-cursor epithelial subtypes. Gut 60 : 1712-1720, 2011.
  • 10) Distler M, Kersting S, Niedergethmann M, et al.: Pathohistological subtype predicts survival in patients with intraductal papillary mucinous neo-plasm(IPMN) of the pancreas. Ann Surg 258 : 324-330, 2013.
  • 11) Qi X, Zhao X, Su J, et al.: Malignant transformation and overall survival of morphological subtypes of intraductal papillary mucinous neoplasms of the pan-creas : A network meta-analysis. Eur J Intern Med 26 : 652-657, 2015.
  • 12) Marchegiani G, Mino-Kenudson M, Ferrone CR, et al.: Patterns of recurrence after resection of IPMN : Who, when, and how? Ann Surg 262 : 1108-1114, 2015.
  • 13) Kang MJ, Lee KB, Jang J-Y, et al.: Disease spectrum of intraductal papillary mucinous neoplasm with an associated invasive carcinoma : Invasive IPMN ver-sus pancreatic ductal adenocarcinoma-associated IPMN. Pancreas 42 : 1267-1274, 2013.
  • 14) Nakahodo J, Fukumura Y, Saito T, et al.: Radiological and pathological assessment of the 2017 revised Iin-ternational Association of Pancreatology consensus guidelines for intraductal papillary mucinous neo-plasm, with an emphasis on the gastric pyloric gland type. Pancreas 49 : 216-223, 2020.
  • 15) Karasaki H, Mizukami Y, Tokusashi Y, et al.: Local-ization of the most severely dysplastic/invasive lesions and mucin phenotypes in intraductal papillary mucinous neoplasm of the pancreas. Pancreas 40 : 588-594, 2011.
  • 16) Tan MC, Basturk O, Brannon AR, et al.: GNAS and KRAS mutations define separate progression path-ways in intraductal papillary mucinous neoplasm-associated carcinoma. J Am Coll Surg 220 : 845-854. e1, 2015.
  • 17) Kuboki Y, Shimizu K, Hatori T, et al.: Molecular bio-markers for progression of intraductal papillary mucinous neoplasm of the pancreas. Pancreas 44 : 227-235, 2015.
  • 18) Omori Y, Ono Y, Tanino M, et al.: Pathways of pro-gression from intraductal papillary mucinous neo-plasm to pancreatic ductal adenocarcinoma based on molecular features. Gastroenterology 156 : 647-661. e2, 2019.
  • 19) Omori Y, Ono Y, Kobayashi T, et al.: How does intes-tinal-type intraductal papillary mucinous neoplasm emerge? CDX2 plays a critical role in the process of intestinal differentiation and progression. Virchows Arch 477 : 21-31, 2020.
  • 20) Omori Y, Ono Y, Morikawa T, et al.: Serine/threo-nine kinase 11 plays a canonical rrole in malignant progression of KRAS-mutant and GNAS-wild-type intraductal papillary mucinous neoplasms of the pan-creas. Ann Surg 277 : e384-e395, 2023.
  • 21) Sato N, Rosty C, Jansen M, et al.: STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papil-lary-mucinous neoplasms of the pancreas. Am J Pathol 159 : 2017-2022, 2001.
  • 22) Sahin F, Maitra A, Argani P, et al.: Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Mod Pathol 16 : 686-691, 2003.
  • 23) Kobayashi T, Omori Y, Ono Y, et al.: Pathways for the development of multiple epithelial types of intra-ductal papillary mucinous neoplasm of the pancreas. J Gastroenterol 56 : 581-592, 2021.
  • 24) Omori Y, Furukawa T, Scarpa A, et al.: Co-occurring IPMN and pancreatic cancer : The same or different? An overview from histology to molecular pathology. J Clin Pathol 76 : 734-739, 2023.
  • 25) Kuboki Y, Fischer CG, Beleva Guthrie V, et al.: Sin-gle-cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions. J Pathol 247 : 347-356, 2019.
  • 26) Fujikura K, Hosoda W, Felsenstein M, et al.: Multire-gion whole-exome sequencing of intraductal papil-lary mucinous neoplasms reveals frequent somatic KLF4 mutations predominantly in low-grade regions. Gut 70 : 928-939, 2021.
  • 27) Noe M, Niknafs N, Fischer CG, et al.: Genomic char-acterization of malignant progression in neoplastic pancreatic cysts. Nat Commun 11 : 4085, 2020.
  • 28) Felsenstein M, Noe M, Masica DL, et al.: IPMNs with co-occurring invasive cancers : Neighbours but not always relatives. Gut 67 : 1652-1662, 2018.
  • 29) Ideno N, Ohtsuka T, Kono H, et al.: Intraductal papil-lary mucinous neoplasms of the pancreas with dis-tinct pancreatic ductal adenocarcinomas are fre-quently of gastric subtype. Ann Surg 258 : 141-151, 2013.
  • 30) Matsuda R, Miyasaka Y, Ohishi Y, et al.: Concomitant intraductal papillary mucinous neoplasm in pancre-atic ductal adenocarcinoma is an independent predic-tive factor for the occurrence of new cancer in the remnant pancreas. Ann Surg 271 : 941-948, 2020.
  • 31) Tamura K, Ohtsuka T, Ideno N, et al.: Treatment strategy for main duct intraductal papillary muci-nous neoplasms of the pancreas based on the assess-ment of recurrence in the remnant pancreas after resection : A retrospective review. Ann Surg 259 : 360-368, 2014.
  • 32) Tamura K, Ohtsuka T, Matsunaga T, et al.: Assess-ment of clonality of multisegmental main duct intra-ductal papillary mucinous neoplasms of the pancreas based on GNAS mutation analysis. Surgery 157 : 277-284, 2015.
  • 33) Pea A, Yu J, Rezaee N, et al.: Targeted DNA sequen-cing reveals patterns of local progression in the pan-creatic remnant following resection of intraductal papillary mucinous neoplasm(IPMN) of the pancreas. Ann Surg 266 : 133-141, 2017.
  • 34) Nagai K, Mizukami Y, Omori Y, et al.: Metachronous intraductal papillary mucinous neoplasms dissemi-nate via the pancreatic duct following resection. Mod Pathol 33 : 971-980, 2020.
  • 35) Kwon JE, Jang K-T, Ryu Y, et al.: Subtype of intra-ductal papillary mucinous neoplasm of the pancreas is important to the development of metachronous high-risk lesions after pancreatectomy. Ann Hepato-biliary Pancreat Surg 23 : 365-371, 2019.
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