アブストラクト
| Title | 全身性エリテマトーデス 中枢神経ループス |
|---|---|
| Subtitle | 特集 膠原病診療update - 診断・治療の最新知見 - II. 主要疾患の診断・治療の進歩 |
| Authors | 藤井隆夫 |
| Authors (kana) | |
| Organization | 和歌山県立医科大学医学部 リウマチ・膠原病科学講座 |
| Journal | 日本臨牀 |
| Volume | 77 |
| Number | 3 |
| Page | 445-449 |
| Year/Month | 2019 / 3 |
| Article | 報告 |
| Publisher | 日本臨牀社 |
| Abstract | 「はじめに」全身性エリテマトーデス(systemic lupus erythematosus: SLE)は, 若年女性に好発する全身性の自己免疫疾患である. 多彩な症状を呈するが, 中枢神経障害(neuropsychiatric SLE: NPSLE)は重症かつ難治性病態の一つとして考えられる. SLE患者の70%に発症すると記載された論文もあり, ひとたび発症すると, SF-36などの患者QOLが低下することも知られている. また, その発症機序には, 自己抗体, 液性因子, 血管障害が関与する可能性が指摘されている. 本稿では, NPSLEの臨床症状を概説し, NPSLEに関連する自己抗体について考察を加えた. 「1. NPSLEの分類と臨床症状」米国リウマチ学会(American College of Rheumatology: ACR)は, SLEによる精神・神経症状を19のサブグループに分類した. |
| Practice | 医学総合 |
| Keywords | neuropsychiatric systemic lupus erythematosus, anti-nuclear antibodies, cerebrospinal fluid |
- 全文ダウンロード： 従量制、基本料金制の方共に1,243円(税込) です。
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残りの13件を表示する
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