アブストラクト
| Title | [合併症の予防と治療] 急性腎障害 (AKI) |
|---|---|
| Subtitle | 特集 エキスパートが直伝! 敗血症の薬学的管理 最新版 |
| Authors | 望月勝徳*1, 松尾純*2, 坂本広登*1 |
| Authors (kana) | |
| Organization | *1信州大学医学部附属病院高度救命救急センター, *2信州大学医学部附属病院薬剤部 |
| Journal | 月刊薬事 |
| Volume | 63 |
| Number | 9 |
| Page | 1777-1782 |
| Year/Month | 2021 / 7 |
| Article | 報告 |
| Publisher | じほう |
| Abstract | [Points] ●急性腎障害(AKI)が合併した敗血症の予後は不良で, 特に腎代替療法(RRT)が必要になる場合は死亡率が高い. ●敗血症治療中の薬剤性腎障害は, 抗菌薬などの新規導入薬剤だけでなく, 既存薬剤の漫然とした継続によっても起こる. ●臨床的に腎保護作用が証明された薬剤はまだないが, AKIの予防および治療の観点から, 敗血症治療中の薬学的介入は重要である. ●RRTが行われる場合, 処方されるRRTに合わせた薬剤投与設計が必要になる. |
| Practice | 薬学 |
| Keywords |
- 全文ダウンロード： 従量制、基本料金制の方共に803円(税込) です。
参考文献
- 1) 日本集中治療医学会・日本救急医学会合同 日本版敗血症診療ガイドライン2020特別委員会・編 : 日本版敗血症診療ガイドライン2020. 日本集中治療医学会雑誌, 28(Suppl.) : S1-S411, 2021
- 2) Bellomo R, et al : Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative(ADQI) Group. Crit Care, 8 : R204-212, 2004
- 3) Mehta RL, et al : Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care, 11 : R31, 2007
- 4) KDIGO AKI Working Group : KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney Int Suppl, 2 : 1-138, 2012
- 5) Fujii T, et al : Diagnosis, management, and prognosis of patients with acute kidney injury in Japanese intensive care units: The JAKID study. J Crit Care, 47 : 185-191, 2018
残りの28件を表示する
- 6) Miyamoto Y, et al : Temporal change in characteristics and outcomes of acute kidney injury on renal replacement therapy in intensive care units: analysis of a nationwide administrative database in Japan, 2007-2016. Crit Care, 23 : 172, 2019
- 7) Peerapornratana S, et al : Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int, 96 : 1083-1099, 2019
- 8) AKI(急性腎障害)診療ガイドライン作成委員会・編 : AKI(急性腎障害)診療ガイドライン2016. 東京医学社, 2016
- 9) Ronco C, et al : Acute kidney injury. Lancet, 394 : 1949-1964, 2019
- 10) 薬剤性腎障害の診療ガイドライン作成委員会・編 : 薬剤性腎障害診療ガイドライン2016. 日本腎臓学会誌, 58 : 477-555, 2016
- 11) Hoste EAJ, et al : Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med, 41 : 1411-1423, 2015
- 12) Mas-Font S, at al : Prevention of acute kidney injury in intensive care units. Med Intensiva, 41 : 116-126, 2017
- 13) Hock R, et al : Prevention of drug-induced nephrotoxicity in the intensive care unit. J Crit Care, 10 : 33-43, 1995
- 14) Bagshaw SM, et al : Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med, 35 : 871-881, 2009
- 15) Luther MK, et al : Vancomycin plus piperacillin-tazobactam and acute kidney injury in adults: A systematic review and meta-analysis. Crit Care Med, 46 : 12-20, 2018
- 16) Nissen SE, et al : Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. N Engl J Med, 375 : 2519-2529, 2016
- 17) 厚生労働省 : 重篤副作用疾患別対応マニュアル 急性腎障害(急性尿細管壊死). 2018 (https://www.mhlw.go.jp/topics/2006/11/dl/tp1122-1e27.pdf)
- 18) Hinson JS, et al : Acute kidney injury following contrast media administration in the septic patient: A retrospective propensity-matched analysis. J Crit Care, 51 : 111-116, 2019
- 19) Hsu YC, et al : Risk of post-contrast acute kidney injury in emergency department patients with sepsis. Hong Kong Med J, 25 : 429-437, 2019
- 20) Bond CAC, et al : Clinical and economic outcomes of pharma-cist-managed aminoglycoside or vancomycin therapy. Am J Health Syst Pharm, 62 : 1596-1605, 2005
- 21) Devlin JW, et al : Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med, 46 : e825-e873, 2018
- 22) Lee BH, et al : Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective obser-vational study. Crit Care, 16 : R33, 2012
- 23) Bagshaw SM, et al : The effect of low-dose furosemide in critically ill patients with early acute kidney injury: A pilot randomized blinded controlled trial(the SPARK study). J Crit Care, 42 : 138-146, 2017
- 24) 西田 修, 他 : 急性血液浄化療法施行時の抗菌薬投与の基本的考え方. ICUとCCU, 37 : 929-937, 2013
- 25) 山本武人 : 薬剤調節. 救急・集中治療, 32 : 539-548, 2020
- 26) Gaudry S, et al : Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomized clinical trials. Lancet, 395 : 1506-1515, 2020
- 27) STARRT-AKI investigators, et al : Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med, 383 : 240-251, 2020
- 28) 菊池 賢, 他・監 : 日本語版 サンフォード 感染症治療ガイド2020. ライフサイエンス出版, 2020
- 29) Onichimowski D, et al : Comparison of adsorption of selected antibiotics on the filters in continuous renal replacement therapy circuits: in vitro studies. J Artif Organs, 23 : 163-170, 2020
- 30) Shotwell MS, et al : Pharmacokinetics and pharmacodynamics of extended infusion versus short infusion piperacillin-tazobactam in critically ill patients undergoing CRRT. Clin J Am Soc Nephrol, 11 : 1377-1383, 2016
- 31) Beumier M, et al : β-lactam antibiotic concentrations during continuous renal replacement therapy. Crit Care, 18 : R105, 2014
- 32) Roberts DM, et al : A multicenter study on the effect of continuous hemodiafiltration intensity on antibiotic pharma-cokinetics. Crit Care, 19 : 84, 2015
- 33) Star RA, et al : Treatment of acute renal failure. Kidney Int, 54 : 1817-1831, 1998
