~
検索条件をクリア

アブストラクト

Title 今後のIBD治療薬の展望
Subtitle 特集 Evidence & Consensusで押さえる IBDの治療薬 最新版 今後の適切なIBD治療に向けて
Authors 竹中健人, 渡辺守
Authors (kana)
Organization 東京医科歯科大学消化器内科
Journal 月刊薬事
Volume 64
Number 12
Page 2522-2526
Year/Month 2022 / 9
Article 報告
Publisher じほう
Abstract [Key Point] ●炎症性腸疾患は, 潰瘍性大腸炎およびクローン病に代表される原因不明の慢性腸疾患で根本治療はない. ●既存の薬剤を用いても治療に難渋する症例も存在し, 長い寛解維持効果や安全性の確保も重要な課題である. ●新たな治療薬として, 「炎症サイトカインを標的とする薬剤」および「炎症細胞の遊走を標的とする薬剤」に大きく分類される. ●一人ひとりの病態に応じて各薬剤を適切に使い分け, 患者ごとの個別化治療をいかに進めていくかが課題である.
Practice 薬学
Keywords
  • 全文ダウンロード: 従量制、基本料金制の方共に803円(税込) です。

参考文献

  • 1) D'Haens GR, et al : Risankizumab induction therapy in patients with moderate-to-severe Crohn's disease with intolerance or inadequate response to conventional and/or biologic therapy : Results from the phase 3 ADVANCE Study. Gastroenterology, 161 : e28, 2021
  • 2) Sandborn WJ, et al : Efficacy and safety of mirikizumab in a randomized phase 2 study of patients with ulcerative colitis. Gastroenterology, 158 : 537-549.e10, 2020
  • 3) Sandborn W, et al : The Efficacy and Safety of Guselkumab Induction Therapy in Patients with Moderately to Severely Active Crohn's Disease : Week 12 Interim Analyses from the Phase 2 GALAXI 1 Study. (Abstract OP089)UEG Week Virtual 2020, 2020
  • 4) Vermeire S, et al : Clinical remission in patients with moderate-to-severe Crohn's disease treated with filgotinib(the FITZROY study) : results from a phase 2, double-blind, randomised, placebo-controlled trial. Lancet, 389 : 266-275, 2017
  • 5) Sandborn WJ, et al : Efficacy and safety of upadacitinib in a randomized trial of patients with Crohn's disease. Gastroenterology, 158 : 2123-2138.e8, 2020
残りの7件を表示する
  • 6) Danese S, et al : Effects of apremilast, an oral inhibitor of phosphodiesterase 4, in a randomized trial of patients with active ulcerative colitis. Clin Gastroenterol Hepatol, 18 : 2526-2534.e9, 2020
  • 7) Danese S, et al : Safety, tolerability and efficacy of anti-TLlA antibody PF-06480605 in treatment of ulcerative colitis : The open-label, multicentre, phase 2a TUSCANY study. J Crohns Colitis, 14 : S108-S110, 2020
  • 8) Matsuoka K, et al : AJM300(carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis : a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Lancet Gastroenterol Hepatol, 7 : 648-657, 2022
  • 9) Sandborn WJ, et al : Efficacy and safety of abrilumab in a randomized, placebo-controlled trial for moderate-to-severe ulcerative colitis. Gastroenterology, 156 : 946-957.e18, 2019
  • 10) Danese S, et al : Ozanimod as maintenance therapy in patients with moderate-to-severe ulcerative colitis : Results from the phase 3, randomized. double-blind. placebo-controlled True North study. Paper presented in late-breaking oral presentation. (#LBlO)UEG Week Virtual 2020, 2020
  • 11) Sugahara K, et al : Amiselimod, a novel sphingosine 1-phosphate receptor-1 modulator, has potent therapeutic efficacy for autoimmune diseases, with low bradycardia risk. Br J Pharmacol, 174 : 15-27, 2017
  • 12) Sandborn WJ, et al : Efficacy and safety of etrasimod in a phase 2 randomized trial of patients with ulcerative colitis. Gastroenterology, 158 : 550-561, 2020