アブストラクト
| Title | 短腸症候群とIFALD |
|---|---|
| Subtitle | 特集 子どもの栄養 - 未来を見据えて 病態による栄養管理の実際 |
| Authors | 渡辺稔彦*,**, 藤野明浩**, 金森豊** |
| Authors (kana) | |
| Organization | *東海大学医学部小児外科, **国立成育医療研究センター外科 |
| Journal | 小児内科 |
| Volume | 53 |
| Number | 11 |
| Page | 1899-1906 |
| Year/Month | 2021 / 11 |
| Article | 報告 |
| Publisher | 東京医学社 |
| Abstract | 「Key Points」(1)新生児の小腸の外科的疾患により大量切除を余儀なくされると短腸症候群となる. (2)IFALDは短腸症侯群による長期静脈栄養に依存する患者に多く発症し, 肝不全に陥る合併症である. (3)シトルリンを小腸の機能的マーカーとしてフォローし, 中心静脈栄養の離脱の指標とする. (4)短腸症候群の栄養管理は多職種によるチームで支援することで予後が改善する. (5)IFALDにはω3系脂肪乳剤は安全で有効であるため, 速やかな臨床治験と薬事承認が得られることを期待する. |
| Practice | 臨床医学：内科系 |
| Keywords |
- 全文ダウンロード： 従量制、基本料金制の方共に1,023円(税込) です。
参考文献
- 1) Kurkchubasche AG, Rowe MI, Smith SD:Adaptation in short-bowel syndrome:reassessing old limits. J Pediatr Surg 28:1069-1071, 1993
- 2) Lloyd DA, Vega R, Bassett P, et al:Survival and dependence on home parenteral nutrition:experience over a 25-year period in a UK referral centre. Aliment Pharmacol Ther 24:1231-1240, 2006
- 3) 金森 豊:新しい知見に基づいた新生児短腸症患児の栄養管理. 臨床栄養(別冊 JCN セレクト 8):215-220, 2013
- 4) 日本静脈慶長栄養学会(編):小児の在宅栄養療法, 静脈経腸栄養ガイドライン, 第3版, 照林社, 東京, pp215-219, 2013
- 5) Wong T, Clifford V, McCallum Z, et al:Central venous catheter thrombosis associated with 70% ethanol locks in pediatric intestinal failure patients on home parenteral nutrition:a case series. JPEN J Parenter Enteral Nutr 36:358-360, 2012
残りの24件を表示する
- 6) Gura KM, Lee S, Valim C, et al:Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics 121:e678-686, 2008
- 7) Fitzgibbons S, Ching YA, Valim C, et al:Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome. J Pediatr Surg 44:928-932, 2009
- 8) Jeppesen PB, Pertkiewicz M, Messing B, et al:Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure. Gastroenterology 143:1473-1481. e3, 2012
- 9) Mercer DF, Hobson BD, Gerhardt BK, et al:Serial transverse enteroplasty allows children with short bowel to wean from parenteral nutrition. J Pediatr 164:93-98, 2014
- 10) Pironi, L, Forbes A, Joly F, et al:Survival of patients identified as candidates for intestinal transplantation:a 3-year prospective follow-up. Gastroenterology 135:61-71, 2008
- 11) Modi BP, Langer M, Ching YA, et al:Improved survival in a multidisciplinary short bowel syndrome program. J Pediatr Surg 43:20-24, 2008
- 12) Kelly DA:Liver complications of pediatric parenteral nutrition--epidemiology. Nutrition 14:153-157, 1998
- 13) Wales PW, de Silva N, Kim J, et al:Neonatal short bowel syndrome:population-based estimates of incidence and mortality rates. J Pediatr Surg 39:690-695, 2004
- 14) Diamond IR, Sterescu A, Pencharz PB, et al:Changing the paradigm:omegaven for the treatment of liver failure in pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 48:209-215, 2009
- 15) 渡辺稔彦, 船山理恵, 山田耕嗣, 他:小腸機能不全関連肝機能障害に対するFish oilの使用経験. 日小児栄消肝学会誌 27:143-147, 2013
- 16) Dyerberg J, Bang HO, Stoffersen E, et al:Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? Lancet 2:117-119, 1978
- 17) Molfino A, Gioia G, Rossi Fanelli F, et al:The role for dietary omega-3 fatty acids supplementation in older adults. Nutrients 6:4058-4073, 2014
- 18) Gura KM, Parsons SK, Bechard LJ, et al:Use of a fish oil-based lipid emulsion to treat essential fatty acid deficiency in a soy allergic patient receiving parenteral nutrition. Clin Nutr 24:839-847, 2005
- 19) Kelly DA:Intestinal failure-associated liver disease:what do we know today? Gastroenterology 130:S70-77, 2006
- 20) Garnett GM, Kang KH, Jaksic T, et al:First STEPs:serial transverse enteroplasty as a primary procedure in neonates with congenital short bowel. J Pediatr Surg 49:104-107;discussion 08, 2014
- 21) Hawksworth JS, Desai CS, Khan KM, et al:Visceral transplantation in patients with intestinal-failure associated liver disease:Evolving indications, graft selection, and outcomes. Am J Transplant 18:1312-1320, 2018
- 22) 天江新太郎, 渡辺稔彦, 和田 基, 他:本邦におけるオメガベン使用の現状と効果. 外科と代謝・栄 50:71-76, 2016
- 23) 有田 誠:メタボローム解析の進歩 脂肪酸代謝と炎症のメタボロミクス. 医のあゆみ 249:318-322, 2014
- 24) Beath SV, Davies P, Papadopoulou A, et al:Parenteral nutrition-related cholestasis in postsurgical neonates:multivariate analysis of risk factors. J Pediatr Surg 31:604-606, 1996
- 25) Kurvinen A, Nissinen MJ, Andersson S, et al:Parenteral plant sterols and intestinal failure-associated liver disease in neonates. J Pediatr Gastroenterol Nutr 54:803-811, 2012
- 26) 渡辺稔彦, 高橋正貴, 大野通暢, 他:小腸機能不全関連肝機能障害に対するω3系脂肪乳剤の効果と適応拡大の可能性. 日静脈経腸栄会誌 32:977-982, 2017
- 27) Sigalet D, Lam V, Boctor D, et al:Nutritional support of infants with intestinal failure:something more than fishy is going on here! Pediatr Surg Int 29:975-981, 2013
- 28) Diamond IR, Grant RC, Pencharz PB, et al:Preventing the Progression of Intestinal Failure-Associated Liver Disease in Infants Using a Composite Lipid Emulsion:A Pilot Randomized Controlled Trial of SMOFlipid. JPEN J Parenter Enteral Nutr 41:866-877, 2017
- 29) Lee S, Park HJ, Yoon J, et al:Reversal of Intestinal Failure-Associated Liver Disease by Switching From a Combination Lipid Emulsion Containing Fish Oil to Fish Oil Monotherapy. JPEN J Parenter Enteral Nutr 40:437-440, 2016
