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Japanese

Title 当院における新生児重症黄疸に対する交換輸血30例の検討
Subtitle 資料
Authors 田中伸久1), 新井菜津子1)
Authors (kana)
Organization 1)群馬県立小児医療センター検査課
Journal 医学検査
Volume 70
Number 3
Page 566-570
Year/Month 2021 / 7
Article 報告
Publisher 日本臨床衛生検査技師会
Abstract 「要旨」交換輸血(exchange transfusion; ET)は, 新生児の重症黄疸にとって有用な治療法である. 2011年から2020年までに当院で行われた新生児の交換輸血事例についてまとめた. 最近10年間に当院で行われた新生児のET 56例のうち, 重症黄疸を理由とした30例を対象に, 診療録のデータから後方視的調査を行った. ET例の83.3%(25/30)が正期産児であり, 86.7%(26/30)が他施設からの搬入であった. 30例のうち母児間のABO不適合と診断されたのは10例で, そのうち母O型, 児B型の組み合わせが8例であった. ABO不適合10例における直接抗グロブリン試験の陽性率は60.0%(6/10)であった. ETに続発して血小板減少など一時的な検査値の異常がみられたが, 死亡例はもちろんのこと臨床的問題の記載は確認されなかった.
Practice 医療技術
Keywords 交換輸血, 新生児重症黄疸, アンバウンドビリルビン, ABO血液型不適合, 新生児, exchange transfusion, severe neonatal jaundice, unbound bilirubin, ABO incompatibility, newborn

English

Title Report of cases of 30 infants with exchange transfusion for severe neonatal jaundice in Gunma Children's Medical Center
Subtitle Materials
Authors Nobuhisa TANAKA1), Natsuko ARAI1)
Authors (kana)
Organization 1)Department of Clinical Laboratory, Gunma Children's Medical Center
Journal Japanese Journal of Medical Technology
Volume 70
Number 3
Page 566-570
Year/Month 2021 / 7
Article Report
Publisher Japanese Association of Medical Technologists
Abstract [Summary] Exchange transfusion (ET) is an effective treatment for severe neonatal jaundice. In this study, we reviewed the cases of infants with ET in Gunma Children's Medical Center from 2011 - 2020. Of the total of 56 infants with ETs, 30 with severe neonatal jaundice were identified. Clinical and laboratory data were collected retrospectively from their medical records. Most infants who underwent ET were full term (gestational age 37 - 41 weeks) (25/30; 83.3%) and were admitted to our hospital after birth (26/30; 86.7%). Out of these 30 infants, 10 were diagnosed as having ABO incompatibility. In eight of these 10 infants, the mothers' blood group was O and the infants' blood group was B. Six of these infants (6/10; 60.0%) showed positive results of the direct antiglobulin test. The identified adverse events secondary to ET included thrombocytopenia and others. The majority of adverse events associated with ET were laboratory abnormalities that were asymptomatic. No deaths or complications were reported arising from the treatment.
Practice Medical technology
Keywords exchange transfusion, severe neonatal jaundice, unbound bilirubin, ABO incompatibility, newborn
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