アブストラクト
Japanese
Title | 重症COVID-19患者に対する急性期リハビリテーション治療の効果 |
---|---|
Subtitle | 原著 |
Authors | 広田桂介*1, 神谷俊次*1, 福島竜也*1, 杉本幸広*1, 松瀬博夫*1, 橋田竜騎*2, 岩永壮平*1, 松岡昌信*3, 高須修*4, 星野友昭*3, 志波直人*2 |
Authors (kana) | |
Organization | *1久留米大学病院リハビリテーション部, *2久留米大学医学部整形外科学講座, *3久留米大学医学部内科学講座呼吸器・神経・膠原病内科部門, *4久留米大学医学部救急医学講座 |
Journal | The Japanese Journal of Rehabilitation Medicine |
Volume | 59 |
Number | 10 |
Page | 1045-1055 |
Year/Month | 2022 / 10 |
Article | 原著 |
Publisher | 日本リハビリテーション医学会 |
Abstract | 「要旨」 重症Coronavirus disease 2019(COVID-19)患者は治療困難例も多く, 集中治療室滞在が長期化した患者に神経学的合併症を引き起こした報告が多数みられる. 重症COVID-19患者に対するリハビリテーション医療は重要とされているが, その有効性を示すプログラムはない. そこで, 当院で作成し使用した重症COVID-19患者に対する発症後の急性期から開始するリハビリテーションプログラムの有効性について検討した. 対象は, 当院重症COVID-19病棟に入院となり, リハビリテーション治療を施行した重症COVID-19患者28人. 年齢中央値61歳, 男女比67.9%:32.1%(19:9), BMI中央値25.0kg/m2. COVID-19重症病棟退出後でCOVID-19中等症病棟入室および退出時におけるMedical Research Council Scoring(MRC)を評価し比較検討した. MRCは, COVID-19中等症病棟入室時の中央値43点であり, 退出時は50点で有意に改善した(p<.001). さらにBarthel Indexにおいても同様に有意な改善が認められた(32.5点 vs. 77.5点, p<.001). 重症COVID-19患者に対する発症後の急性期から開始するリハビリテーション治療は, 筋力や日常生活を改善させる可能性がある. |
Practice | 医療技術 |
Keywords | リハビリテーションプログラム(rehabilitation program), 骨格筋量(muscle mass), 筋力(muscle strength), コロナウイルス感染症(coronavirus disease 2019), 急性期リハビリテーション治療(acute rehabilitation treatment) |
English
Title | Effect of Acute Rehabilitation Treatment for Patients with Severe COVID-19 |
---|---|
Subtitle | |
Authors | Keisuke Hirota*1, Shunji Koya*1, Tatsuya Fukushima*1, Takahiro Sugimoto*1, Hiroo Matsuse*1, Ryuki Hashida*2, Souhei Iwanaga*1, Masanobu Matsuoka*3, Osamu Takasu*4, Tomoaki Hoshino*3, Naoto Shiba*2 |
Authors (kana) | |
Organization | *1Division of Rehabilitation, Kurume University Hospital, *2Department of Orthopedics, Kurume University School of Medicine, *3Division of Respirology, Neurology, and Rheumatology, Kurume University School of Medicine, *4Department of Emergency and Critical Care Medicine, Kurume University School of Medicine |
Journal | The Japanese Journal of Rehabilitation Medicine |
Volume | 59 |
Number | 10 |
Page | 1045-1055 |
Year/Month | 2022 / 10 |
Article | Original article |
Publisher | The Japanese Association of Rehabilitation Medicine |
Abstract | [Abstract] Patients with severe coronavirus disease 2019 (COVID-19) have poor prognosis, with many cases being difficult to treat and many reports of neurological complications in patients who have been in the intensive care unit for a long time. Rehabilitation of patients with severe COVID-19 is important ; however, no rehabilitation program has shown effectiveness. Thus, this study aimed to investigate the effects of a rehabilitation program developed and used at our hospital for patients with severe COVID-19. We enrolled 28 patients with severe COVID-19 (age 61 [23-88] years ; female/male, 9/19, body mass index, 25.0 [18.0-33.6]kg/m2). We assessed the medical research council scoring (MRC) of the patients at the time of entry and exit from the ordinary ward using Wilcoxon signed-rank tests. MRC was significantly improved after exiting the ordinary ward compared with that on entering the ordinary ward (43 vs. 50 points ; P<.001). Moreover, Barthel index improved significantly after exiting the ordinary (32.5 vs. 77.5 points, P<.001). Therefore, our acute rehabilitation treatment for patients with severe COVID-19 may be effective in improving their muscle strength and daily living. |
Practice | Medical technology |
Keywords | rehabilitation program, muscle mass, muscle strength, coronavirus disease 2019, acute rehabilitation treatment |
- 全文ダウンロード: 従量制、基本料金制の方共に770円(税込) です。
参考文献
- 1) Rai P, Kumar BK, Deekshit VK, Karunasagar I, Karunasagar I: Detection technologies and recent developments in the diagnosis of COVID-19 infection. Appl Microbiol Biotechnol 2021;105:441-455
- 2) Cheng YY, Chen CM, Huang WC, Chiang SL, Hsieh PC, Lin KL, Chen YJ, Fu TC, Huang SC, Chen SY, Chen CH, Chen SM, Chen HS, Chou LW, Chou CL, Li MH, Tsai SW, Wang LY, Wang YL, Chou W: Rehabilitation programs for patients with COronaVIrus Disease 2019: consensus statements of Taiwan Academy of Cardiovascular and Pulmonary Rehabilitation. J Formos Med Assoc 2021;120:83-92
- 3) Tsai SC, Lu CC, Bau DT, Chiu YJ, Yen YT, Hsu YM, Fu CW, Kuo SC, Lo YS, Chiu HY, Juan YN, Tsai FJ, Yang JS: Approaches towards fighting the COVID19 pandemic (Review). Int J Mol Med 2021;47:3-22
- 4) Hu SL, He HL, Pan C, Liu AR, Liu SQ, Liu L, Huang YZ, Guo FM, Yang Y, Qiu HB: The effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. Crit Care 2014;18:R109
- 5) Huyut MT, Ilkbahar F: The effectiveness of blood routine parameters and some biomarkers as a potential diagnostic tool in the diagnosis and prognosis of Covid-19 disease. Int Immunopharmacol 2021;98:107838
残りの38件を表示する
- 6) Bax F, Lettieri C, Marini A, Pellitteri G, Surcinelli A, Valente M, Budai R, Patruno V, Gigli GL: Clinical and neurophysiological characterization of muscular weakness in severe COVID-19. Neurol Sci 2021;42:2173-2178
- 7) Lad H, Saumur TM, Herridge MS, Dos Santos CC, Mathur S, Batt J, Gilbert PM: Intensive Care Unit-Acquired Weakness: Not just Another Muscle Atrophying Condition. Int J Mol Sci 2020;21:7840
- 8) Ulutas F, S N Oztekin S, Ardic F: Role of rehabilitation in a COVID-19 survivor with intensive care unit-acquired weakness: A case report. Turk J Phys Med Rehabil 2021;67:115-119
- 9) Hermans G, Van den Berghe G: Clinical review: intensive care unit acquired weakness. Crit Care 2015;19:274
- 10) Appleton RT, Kinsella J, Quasim T: The incidence of intensive care unit-acquired weakness syndromes: A systematic review. J Intensive Care Soc 2015;16:126-136
- 11) Ali NA, O'Brien JM Jr, Hoffmann SP, Phillips G, Garland A, Finley JC, Almoosa K, Hejal R, Wolf KM, Lemeshow S, Connors AF Jr, Marsh CB, Midwest Critical Care Consortium: Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med 2008;178:261-268
- 12) Pincherle A, Johr J, Pancini L, Leocani L, Dalla Vecchia L, Ryvlin P, Schiff ND, Diserens K: Intensive Care Admission and Early Neuro-Rehabilitation. Lessons for COVID-19? Front Neurol 2020;11:880
- 13) Felten-Barentsz KM, van Oorsouw R, Klooster E, Koenders N, Driehuis F, Hulzebos EHJ, van der Schaaf M, Hoogeboom TJ, van der Wees PJ: Recommendations for Hospital-Based Physical Therapists Managing Patients With COVID-19. Phys Ther 2020;100:1444-1457
- 14) Ali AM, Kunugi H: Skeletal Muscle Damage in COVID-19: A Call for Action. Medicina (Kaunas) 2021;57:372
- 15) Koya S, Kawaguchi T, Hashida R, Hirota K, Bekki M, Goto E, Yamada M, Sugimoto M, Hayashi S, Goshima N, Yoshiyama T, Otsuka T, Nozoe R, Nagamatsu A, Nakano D, Shirono T, Shimose S, Iwamoto H, Niizeki T, Matsuse H, Koga H, Miura H, Shiba N, Torimura T: Effects of in-hospital exercise on sarcopenia in hepatoma patients who underwent transcatheter arterial chemoembolization. J Gastroenterol Hepatol 2019;34:580-588
- 16) Schneider CA, Rasband WS, Eliceiri KW: NIH Image to ImageJ: 25 years of image analysis. Nat Methods 2012;9:671-675
- 17) Mitobe Y, Morishita S, Ohashi K, Sakai S, Uchiyama M, Abeywickrama H, Yamada E, Kikuchi Y, Nitta M, Honda T, Endoh H, Kimura S, Sakano S, Koyama Y: Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis. J Clin Med Res 2019;11:834-841
- 18) Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-829
- 19) Damarla M, Zaeh S, Niedermeyer S, Merck S, Niranjan-Azadi A, Broderick B, Punjabi N: Prone Positioning of Nonintubated Patients with COVID-19. Am J Respir Crit Care Med 2020;202:604-606
- 20) Nakamura K, Kihata A, Naraba H, Kanda N, Takahashi Y, Sonoo T, Hashimoto H, Morimura N: Efficacy of belt electrode skeletal muscle electrical stimulation on reducing the rate of muscle volume loss in critically ill patients: A randomized controlled trial. J Rehabil Med 2019;51:705-711
- 21) Barisic A, Leatherdale ST, Kreiger N: Importance of frequency, intensity, time and type (FITT) in physical activity assessment for epidemiological research. Can J Public Health 2011;102:174-175
- 22) 植木 純, 神津 玲, 大平徹郎: 呼吸リハビリテーションに関するステートメント. 日本呼吸ケア・リハビリテーション学会誌 2018;27:95-114
- 23) Thomas P, Baldwin C, Bissett B, Boden I, Gosselink R, Granger CL, Hodgson C, Jones AY, Kho ME, Moses R, Ntoumenopoulos G, Parry SM, Patman S, van der Lee L: Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations. J Physiother 2020;66:73-82
- 24) Csapo R, Alegre LM: Effects of resistance training with moderate vs heavy loads on muscle mass and strength in the elderly: A meta-analysis. Scand J Med Sci Sports 2016;26:995-1006
- 25) American College of Sports Medicine: American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 2009;41:687-708
- 26) Righetti RF, Onoue MA, Politi FVA, Teixeira DT, Souza PN, Kondo CS, Moderno EV, Moraes IG, Maida ALV, Pastore Junior L, Silva FD, Brito CMM, Baia WRM, Yamaguti WP: Physiotherapy Care of Patients with Coronavirus Disease 2019 (COVID-19)-A Brazilian Experience. Clinics (Sao Paulo) 2020;75:e2017
- 27) Wall BT, Dirks ML, van Loon LJ: Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing Res Rev 2013;12:898-906
- 28) Howard EE, Pasiakos SM, Fussell MA, Rodriguez NR: Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury. Adv Nutr 2020;11:989-1001
- 29) Powers SK, Morton AB, Hyatt H, Hinkley MJ: The Renin-Angiotensin System and Skeletal Muscle. Exerc Sport Sci Rev 2018;46:205-214
- 30) Gonzalez A, Orozco-Aguilar J, Achiardi O, Simon F, Cabello-Verrugio C: SARS-CoV-2/Renin-Angiotensin System: Deciphering the Clues for a Couple with Potentially Harmful Effects on Skeletal Muscle. Int J Mol Sci 2020;21:7904
- 31) De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, Cerf C, Renaud E, Mesrati F, Carlet J, Raphael JC, Outin H, Bastuji-Garin S, Groupe de Reflexion et d'Etude des Neuromyopathies en Reanimation: Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002;288:2859-2867
- 32) Lee N, Hui D, Wu A, Chan P, Cameron P, Joynt GM, Ahuja A, Yung MY, Leung CB, To KF, Lui SF, Szeto CC, Chung S, Sung JJ: A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003;348:1986-1994
- 33) Parry SM, Puthucheary ZA: The impact of extended bed rest on the musculoskeletal system in the critical care environment. Extrem Physiol Med 2015;4:16
- 34) 広田桂介, 山下陽子, 前田貴司, 志波直人, 宮城知也, 坂本照夫: 三次救急施設 (救命救急センター) における理学療法士専属配置の有用性の検討. 理学療法 2013;30:1145-1148
- 35) Smondack P, Gravier FE, Prieur G, Repel A, Muir JF, Cuvelier A, Combret Y, Medrinal C, Bonnevie T: Physiotherapy and COVID-19. From intensive care unit to home care- An overview of international guidelines. Rev Mal Respir 2020;37:811-822
- 36) Parry SM, Chapple LS, Mourtzakis M: Exploring the Potential Effectiveness of Combining Optimal Nutrition With Electrical Stimulation to Maintain Muscle Health in Critical Illness: A Narrative Review. Nutr Clin Pract 2018;33:772-789
- 37) 一般社団法人日本呼吸療法医学会 ARDS診療ガイドライン作成委員会: ARDS診療ガイドライン2016. 人工呼吸. Jpn Respir Care 2016;33:113-120
- 38) Kaniusas E, Szeles JC, Kampusch S, Alfageme-Lopez N, Yucuma-Conde D, Li X, Mayol J, Neumayer C, Papa M, Panetsos F: Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome. Front Physiol 2020;11:890
- 39) Chinese Research Hospital Association, Respiratory Council: [Expert recommendations for the diagnosis and treatment of interstitial lung disease caused by novel coronavirus pneumonia]. Zhonghua Jie He He Hu Xi Za Zhi 2020;43:827-833
- 40) Wallaert B, Masson N, Le Rouzic O, Chehere B, Wemeau-Stervinou L, Grosbois JM: Effects of pulmonary rehabilitation on daily life physical activity of fibrotic idiopathic interstitial pneumonia patients. ERJ Open Res 2018;4:00167-2017
- 41) Thomas P, Baldwin C, Bissett B, Boden I, Gosselink R, Granger CL, Hodgson C, Jones AY, Kho ME, Moses R, Ntoumenopoulos G, Parry SM, Patman S, van der Lee L: Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations. J Physiother 2020;66:73-82
- 42) Zhu Y, Wang Z, Zhou Y, Onoda K, Maruyama H, Hu C, Liu Z: Summary of respiratory rehabilitation and physical therapy guidelines for patients with COVID-19 based on recommendations of World Confederation for Physical Therapy and National Association of Physical Therapy. J Phys Ther Sci 2020;32:545-549
- 43) Goodwin VA, Allan L, Bethel A, Cowley A, Cross JL, Day J, Drummond A, Hall AJ, Howard M, Morley N, Thompson Coon J, Lamb SE: Rehabilitation to enable recovery from COVID-19: a rapid systematic review. Physiotherapy 2021;111:4-22