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Japanese

Title 発作前駆期rizatriptan内服とamitriptyline予防投与が奏効した重症周期性嘔吐症の1例
Subtitle 症例報告
Authors 守山汐理1, 下郷幸子2, 米山浩志3, 水上愛弓1, 高橋孝雄4
Authors (kana)
Organization 1国家公務員共済組合連合会立川病院小児科, 2新百合ヶ丘総合病院小児科, 3公立福生病院小児科, 4慶應義塾大学医学部小児科
Journal 脳と発達
Volume 57
Number 1
Page 49-52
Year/Month 2025 / 1
Article 報告
Publisher 日本小児神経学会
Abstract 「要旨」周期性嘔吐症に対しrizatriptan口腔内崩壊錠が有効であった症例を経験した. 本症例においては, rizatriptanはsumatriptanに比し有効性・忍容性に優れていた. 周期性嘔吐症は片頭痛との関連が指摘されているが, 詳細な病態は不明である. 発作期には対症療法が主体であり, 確立した治療法はないがsumatriptan点鼻/皮下注が有効とする報告が散見される. 周期性嘔吐症の病態およびrizatriptanが治療選択肢となりうる可能性について考察する.
Practice 臨床医学:内科系
Keywords 周期性嘔吐症, 片頭痛, rizatriptan, sumatriptan, amitriptyline, cyclic vomiting syndrome, migraine

English

Title Case of severe cyclic vomiting syndrome successfully treated with oral rizatriptan during the prodromal phase and amitriptyline
Subtitle Case Reports
Authors Shiori Moriyama1, Sachiko Shimozato2, Hiroshi Yoneyama3, Ayumi Mizukami1, Takao Takahashi4
Authors (kana)
Organization 1Department of Pediatrics, Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, 2Department of Pediatrics, Shin-yurigaoka General Hospital, 3Department of Pediatrics, Fussa Hospital, 4Department of Pediatrics, Keio University Hospital
Journal NO TO HATTATSU (Official Journal of The Japanese Society of Child Neurology)
Volume 57
Number 1
Page 49-52
Year/Month 2025 / 1
Article Report
Publisher The Japanese Society of Child Neurology
Abstract We report a case in which rizatriptan oral disintegrating tablet was effective in the prodromal phase. In this case, rizatriptan was superior in efficacy and tolerability compared with sumatriptan. Cyclic vomiting syndrome is associated with migraine, however, the etiology and pathogenesis remain unknown. Supportive therapy is common during the attack phase. In some cases, sumatriptan nasal spray/subcutaneous injection during the attack phase was effective. We discuss the possibility that rizatriptan can be a therapeutic option for severe cyclic vomiting syndrome.
Practice Clinical internal medicine
Keywords cyclic vomiting syndrome, migraine, rizatriptan, sumatriptan, amitriptyline
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