Japanese

Title	スギ花粉大量飛散年におけるスギ花粉舌下免疫療法の治療効果とヒノキ花粉症への効果
Subtitle	原著
Authors	湯田厚司1)2), 小川由起子1), 神前英明2), 清水猛史2)
Authors (kana)
Organization	1)ゆたクリニック, 2)滋賀医科大学耳鼻咽喉科
Journal	アレルギー
Volume	72
Number	10
Page	1230-1239
Year/Month	2023 /
Article	原著
Publisher	日本アレルギー学会
Abstract	【背景】スギ花粉大量飛散年(総数12353個/cm2, 平年比約4倍)にスギとヒノキ花粉症への舌下免疫療法(SLIT)の効果を検討した. 【方法】シダキュア(R)治療のSLIT 1年目84例, 2年目107例, 3年目67例を対象とした. 2023年スギ・ヒノキ期の鼻眼と全般症状をVisual analog scale(VAS)で検討した. 【結果】スギ期症状は治療年数が増えると有意にVASが小さくなったが, ヒノキ期にはむしろやや大きかった(悪化). SLIT前でスギ期よりヒノキ期に自覚症状の強い例はわずか0.9-3.6%であったが, SLITにより治療3年目のVASでは, くしゃみ(p<0.01), 鼻水, 眼痒みと全般症状(p<0.05)でヒノキ期がスギ期より高かった. スギ期全般症状VASは花粉飛散数に影響されず, 完治率はSLIT 3年目で影響を受けた. 【結論】大量飛散年でもスギSLITのスギ花粉症効果は高く, 経年的に効果が増強したが, ヒノキ花粉症には経年的にVASによる症状の悪化があった.
Practice	臨床医学：内科系
Keywords	Cedarcure(R), cedar pollen, clinical efficacy, cypress pollen, sublingual immunotherapy

English

Title	CLINICAL EFFICACY OF SUBLINGUAL IMMUNOTHERAPY WITH CEDAR POLLEN IN A YEAR OF MASSIVE CEDAR POLLEN DISPERSAL AND ITS EFFECT ON JAPANESE CYPRESS POLLINOSIS
Subtitle
Authors	Atsushi Yuta1)2), Yukiko Ogawa1), Hideaki Kozaki2), Takeshi Shimizu2)
Authors (kana)
Organization	1)Yuta Clinic, 2)Department of Otorhinolaryngology, Shiga University of Medical Science
Journal	Japanese Journal of Allergology
Volume	72
Number	10
Page	1230-1239
Year/Month	2023 /
Article	Original article
Publisher	JAPANESE SOCIETY OF ALLERGOLOGY
Abstract	[Background]: We investigated the effect of sublingual immunotherapy (SLIT) on Japanese cedar and cypress pollinosis in a mass scattering year of cedar pollen (total counts: 12353 grains/cm2, approximately four times the average). [Methods]: SLIT patients of 84 in the first year, 107 in the second year and 67 in the third year treated with Cedarcure(R) were included. During the 2023 cedar and cypress pollen dispersal season, nasal and eye symptoms and general symptoms were examined using a visual analog scale (VAS). [Results]: The VAS during the cedar season significantly decreased to improve with the number of years of SLIT, but the VAS during the cypress period slightly increased. A questionnaire survey before SLIT revealed that only 0.9% to 3.6% of patients had strong cypress symptoms. However, sneezing (p < 0.01), rhinorrhea, itchy eyes and total symptoms (p < 0.05) in the third year of SLIT were significantly stronger during the cypress period than during the cedar period. The VAS of total symptoms during the Japanese cedar pollen season were not affected by the pollen count, and the cure rate was affected by SLIT in the third year. [Conclusion]: The clinical efficacy of cedar SLIT on cedar pollinosis was high even in a mass scattering year, and the effect increased with the number of years of treatment. On the other hand, it was shown that the clinical efficacy on cypress pollinosis was insufficient.
Practice	Clinical internal medicine
Keywords	Cedarcure(R), cedar pollen, clinical efficacy, cypress pollen, sublingual immunotherapy

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