アブストラクト
Japanese
| Title | 舌下免疫療法が原因と考えられる喉頭浮腫2例 |
|---|---|
| Subtitle | 症例報告 |
| Authors | 丸山祐樹1), 平野康次郎1), 関野恵里子2), 上村佐和3), 成川陽一郎2), 洲崎勲夫1), 嶋根俊和1) |
| Authors (kana) | |
| Organization | 1)昭和大学医学部耳鼻咽喉科頭頸部外科学講座, 2)労働者安全機構関東労災病院耳鼻咽喉科・頭頸部外科, 3)昭和大学藤が丘病院耳鼻咽喉科 |
| Journal | アレルギー |
| Volume | 73 |
| Number | 2 |
| Page | 196-200 |
| Year/Month | 2024 / |
| Article | 報告 |
| Publisher | 日本アレルギー学会 |
| Abstract | 舌下免疫療法(SLIT)は広く行われている治療法であり, アナフィラキシーなどの重篤な副反応は稀である. SLITの副反応に喉頭浮腫をきたしたが, 投与方法の変更により継続できた2症例を報告する. 症例1は15歳男性. 6歳時に埃によるアナフィラキシーを起こした疑いがある. ミティキュア(R)10000JAU投与10日目の服用30分後に喉頭浮腫を認め, 静脈内点滴で治療された. 症例2は48歳の女性. シダキュア(R)5000JAU投与5日目の服用1時間後に呼吸苦があり, 喉頭浮腫を認めたが治療介入なく軽快した. いずれの症例も, 舌下吐き出し法に変更し初回投与量から慎重に再開し, 継続可能であった. SLITは安全な治療法だが, 緊急を要する副反応が発生する可能性もある. 喉頭症状が出現しても, 舌下吐き出し法への変更により継続可能な例があると考えた. |
| Practice | 臨床医学：内科系 |
| Keywords | laryngeal edema, spit out, sublingual immunotherapy |
English
| Title | TWO CASES OF LARYNGEAL EDEMA CAUSED BY SUBLINGUAL ALLERGEN IMMUNOTHERAPY |
|---|---|
| Subtitle | |
| Authors | Yuki Maruyama1), Kojiro Hirano1), Eriko Sekino2), Sawa Kamimura3), Youichirou Narikawa2), Isao Suzaki1), Toshikazu Shimane1) |
| Authors (kana) | |
| Organization | 1)Department of Otorhinolaryngology Head and neck surgery, Showa University, School of Medicine, 2)Department of Otorhinolaryngology Head and neck surgery, Kanto Rosai Hospital, 3)Department of Otorhinolaryngology, Showa University, Fujigaoka Hospital |
| Journal | Japanese Journal of Allergology |
| Volume | 73 |
| Number | 2 |
| Page | 196-200 |
| Year/Month | 2024 / |
| Article | Report |
| Publisher | JAPANESE SOCIETY OF ALLERGOLOGY |
| Abstract | Sublingual immunotherapy is a widely used treatment, and serious adverse reactions such as anaphylaxis are rare. We report two cases of laryngeal edema as adverse reactions to sublingual immunotherapy, which could be continued due to a change in the administration method. Case 1 presents a 15-year-old male suspected to have had anaphylaxis due to the dust at the age of 6 years. He started treatment with Miticure(R) and developed laryngeal edema 30 minutes after taking the 10000JAU dose on the 10th day. laryngeal edema was treated with intravenous infusion. Case 2 presents a 48-year-old woman. She started treatment with Cidacure(R) and developed respiratory distress and laryngeal edema 1 hour after taking the 5000JAU dose on the 5th day. she had resolved mildly without therapeutic intervention. In both cases, the patients were switched to sublingual spitting, resumed with the initial dose cautiously, and were able to continue. Sublingual immunotherapy is a safe treatment, but sudden adverse reactions may occur. Laryngeal symptoms may be treated by changing to the sublingual spitting method, but laryngeal findings should be examined, and the dosage should be carefully increased. |
| Practice | Clinical internal medicine |
| Keywords | laryngeal edema, spit out, sublingual immunotherapy |
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