Japanese

Title	猪肉の摂取で発症したα-Gal syndromeの2例
Subtitle	症例報告
Authors	服部尚子1)2), 松本舞1), 千貫祐子3), 竹中基1), 富村沙織4), 塚崎直子5), 室田浩之1)
Authors (kana)
Organization	1)長崎大学大学院医歯薬学総合研究科皮膚病態学, 2)同 生化学, 3)島根大学医学部皮膚科学講座, 4)とみむら皮ふ科, 5)つかざき皮ふ科
Journal	アレルギー
Volume	73
Number	8
Page	995-999
Year/Month	2024 /
Article	報告
Publisher	日本アレルギー学会
Abstract	α-Gal syndrome(AGS)は, マダニ咬傷を契機にマダニの唾液腺に含まれるgalactose-α-1,3-galactose(α-gal)に感作され, その後α-galを含む獣肉の経口摂取やα-galを含むセツキシマブなどの抗体製剤の投与によりアレルギー症状が出現する疾患である. 猪肉摂取を契機にAGSと診断した2例を報告する. 症例1は70代, 男性. 猪肉摂取の約3時間後にアナフィラキシーショックを発症し, 長崎大学病院高度救命救急センターへ緊急搬送された. 症例2は60代, 女性. 猪肉摂取の約2.5時間後に膨疹が出現したため, 近医を受診した. 2例とも精査目的に同皮膚科・アレルギー科を初診し, α-gal特異的IgEが陽性で, AGSと診断した. 国内で猪肉摂取を契機に診断されたAGSの報告は少数である. 長崎県は, 猪肉摂取の機会が多い地域である. 過去10年間に当科で診断したAGS患者は4例で, その半数は猪肉摂取が原因であり, この割合は他の地域よりも高い可能性がある.
Practice	臨床医学：内科系
Keywords	anaphylaxis, galactose-α-1,3-galactose, tick bites, red meat allergy, wild boar

English

Title	TWO CASES OF α-GAL SYNDROME CAUSED BY INGESTION OF WILD BOAR MEAT
Subtitle
Authors	Naoko Hattori1)2), Mai Matsumoto1), Yuko Chinuki3), Motoi Takenaka1), Saori Tomimura4), Naoko Tsukazaki5), Hiroyuki Murota1)
Authors (kana)
Organization	1)Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 2)Department of Biochemistry, Nagasaki University Graduate School of Biomedical Sciences, 3)Department of Dermatology, Shimane University Faculty of Medicine, 4)Tomimura Dermatology Clinic, 5)Tsukazaki Dermatology Clinic
Journal	Japanese Journal of Allergology
Volume	73
Number	8
Page	995-999
Year/Month	2024 /
Article	Report
Publisher	JAPANESE SOCIETY OF ALLERGOLOGY
Abstract	α-Gal syndrome (AGS) is an allergic reaction to galactose-α-1,3-galactose (α-gal) found in the salivary glands of ticks, mammalian meat excluding primates, and some antibody preparations, such as cetuximab. We report two cases of AGS diagnosed after ingestion of wild boar meat. Patient 1, a male in his 70s, developed anaphylactic shock about 3 h after eating wild boar meat. He was transported to our acute and critical care center in Nagasaki University Hospital because he had difficulty in moving. Patient 2, a female in her 60s, developed a skin rash about 2.5 h after ingesting wild boar meat. After visiting our department to investigate the cause of the disease, the sera of both patients were found to be positive for α-gal specific IgE antibody and were diagnosed with AGS caused by ingestion of wild boar meat. Reports of AGS diagnosed after ingestion of wild boar meat are rare in Japan. Compared with other prefectures, the consumption of wild boar meat in Nagasaki is relatively high in Japan. In the past 10 years, four cases of AGS were diagnosed at our department, half of which were caused by the ingestion of wild boar meat, the ratio is possibly higher than that in other prefectures in Japan.
Practice	Clinical internal medicine
Keywords	anaphylaxis, galactose-α-1,3-galactose, tick bites, red meat allergy, wild boar

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