アブストラクト
Japanese
| Title | 人工股関節周囲感染に対する持続的局所抗菌薬灌流 (CLAP) 療法 |
|---|---|
| Subtitle | 特集 : 外科領域における持続局所高濃度抗菌薬灌流 (CLAP) 療法の実際 症例報告 |
| Authors | 内山勝文 |
| Authors (kana) | |
| Organization | 北里大学医学部医学教育研究開発センター 医療安全・管理学研究部門 |
| Journal | 日本外科感染症学会雑誌 |
| Volume | 20 |
| Number | 4 |
| Page | 507-512 |
| Year/Month | 2023 / |
| Article | 報告 |
| Publisher | 日本外科感染症学会 |
| Abstract | 要旨:近年, 外傷に伴う骨軟部感染症に対して, 局所に必要な濃度の抗菌薬を持続投与し, 陰圧を用いて病巣部に抗菌薬を誘導, ドレナージすることで感染の鎮静化を図るContinuous Local Antibiotics Perfusion(以下, CLAP)が報告されている. CLAPは, 抗菌薬のdrug deliveryの新たな形態とも考えられており, 骨髄腔に対してはintra-Medullary Antibiotics Perfusion(iMAP), 軟部組織に対してはintra-Soft tissue Antibiotics Perfusion(以下, iSAP), 関節内に施行した場合は, intra-Joint Antibiotics Perfusion(以下, iJAP)と称されている. われわれはCLAPを人工股関節周囲感染に対して施行(iJAP)したので, その経験につき報告する. |
| Practice | 臨床医学：外科系 |
| Keywords | periprosthetic joint infection(人工関節周囲感染), continuous local antibiotics perfusion(抗菌薬局所持続灌流療法), intra-joint antibiotics perfusion:iJAP(関節内抗菌薬灌流) |
English
| Title | Continuous Local Antibiotics Perfusion (CLAP) for Periprosthetic joint infection of the hip : A case report |
|---|---|
| Subtitle | |
| Authors | Katsufumi Uchiyama |
| Authors (kana) | |
| Organization | Department of Patient Safety and Healthcare Administration, School of Medicine, Kitasato University |
| Journal | Journal of Japan Society for Surgical Infection |
| Volume | 20 |
| Number | 4 |
| Page | 507-512 |
| Year/Month | 2023 / |
| Article | Report |
| Publisher | Japan Society for Surgical Infection |
| Abstract | Periprosthetic joint infection (PJI) of the hip is difficult to treat due to biofilm formation around the implant. Systemic administration of antibiotics is known to be ineffective against biofilms due to poor penetration into poorly vascularized tissues. The goal of PJI treatment is to achieve a therapeutic infection while retaining the implant. Our proposal, continuous local antibiotic perfusion (CLAP), delivers sufficient antibiotics locally and continuously to sites of bone and soft tissue infection, including around implants in the hip joint via a needle as intramedullary antibiotic perfusion. It is a delivery system that delivers to the soft tissue with dual antibiotic perfusion. Lumen hypodermic tubing as intra-soft tissue perfusion. We report a late chronic periprosthetic joint infection of the hip using CLAP treatment with implant preservation. |
| Practice | Clinical surgery |
| Keywords |
- 全文ダウンロード： 従量制、基本料金制の方共に770円(税込) です。
